Digital Commons Network^™

The First Principles Of Chinese Civilization: Relationalism And Pragmatism, Sai Zhang, Yongnian Zheng

Comparative Civilizations Review

This article examines the first principles of Chinese civilization, relationalism and pragmatism, through Liah Greenfeld’s (2024) definition of civilization as a distinct cultural reality. By comparing Chinese civilization with others, particularly in the context of globalization, we seek to identify its distinctive characteristics. Our overview analysis draws on interdisciplinary literature (including linguistics, philosophy, sociology, political economy, and social psychology). We argue that the complexities of Chinese civilization require a nuanced understanding of its first principles, which are codified in language and cognition. The article explores how these principles manifest in mainstream thoughts such as Confucianism and Legalism, influencing social structure …

The Impact Of Social Factors On Vagally Mediated Parasympathetic Activity, Andrew Scot Proctor

Theses and Dissertations

Loneliness and social disconnection are recognized risk factors for morbidity and mortality, yet the psychophysiological pathways remain contested. This dissertation examines how social factors relate to vagally mediated parasympathetic activity indexed by heart rate variability (HRV) and tests whether conversational interventions with a human or a large-language-model (LLM)-based companion can acutely reduce loneliness and enhance connection. Across two university sites (BYU, UCSD), N=297 participants (18-27 years) were randomized to (a) a reciprocal self-disclosure conversation with a trained human confederate, (b) a parallel, vocalized LLM chatbot conversation, or (c) a non-social, vocal reading control. Resting HRV (RMSSD, SDNN, HF-HRV) was recorded …

Beyond Earth: Strategic Pathways To A Multiplanet Civilization And The Case For Mars Settlement, Andrew Targowski

Comparative Civilizations Review

This research provides a comprehensive and interdisciplinary exploration of the transition toward a multiplanet civilization, with a special focus on Mars as humanity’s first major step beyond Earth. By addressing technological, political, economic, and ethical dimensions, it aims to inform policymakers, scientists, and the public about the feasibility, challenges, and philosophical implications of interplanetary expansion.

As humanity approaches the threshold of becoming a multiplanet civilization, it faces unprecedented scientific, technological, economic, and ethical challenges. This paper explores the rationale, methodologies, and critical considerations for establishing sustainable human settlements beyond Earth, with a particular focus on Mars. By analyzing advances in …

The Role Of The Cytosolic Chaperonin Cct In The Folding And Assembly Of G Protein Complexes, Mikaila I. Sass

Theses and Dissertations

All organisms depend on cellular signaling pathways to dictate cell growth, responses to stimuli, and all other cellular functions necessary to maintain health and survival. Many of these signals rely on G protein coupled receptors (GPCRs) and their associated heterotrimeric G proteins for signal detection and transduction. To perform this function, the three subunits of the G protein must be assembled after synthesis on the ribosome. This process requires additional proteins called molecular chaperones to assist in folding of the subunits and assembly into the G protein heterotrimer. Among these chaperones, the cytosolic chaperonin CCT plays an essential role in …

Transgenerational Impacts Of Covid-19: Exploring The Epigenetic Impacts Of Sars-Cov-2 Infection On Parental Reproductive Health And Offspring Development, Isaac Mckay Stirland

Theses and Dissertations

The mechanisms and consequences of SARS-CoV-2 infection, including clinical manifestations, immune response, pathogenicity, long-term sequelae, etc., have been studied in detail following the 2019 pandemic however, very little has been done to explore the interplay between SARS-CoV-2 and host DNA methylation. Given the role of DNA methylation in genetic regulation, genomic imprinting, and induction of transgenerational effects, an understanding of viral interaction(s) with the host methylome is imperative in promoting reproductive and developmental health. Numerous reports describe infections with similar pathogenicity to SARS-CoV-2 and their correlation to altered host tissues at the epigenetic, physiologic, and macroscopic level. These reported epigenetic …

Spiritual Implications Of The Timing Of The Death Of Jesus Christ, C. Thomas Black

Interpreter: A Journal of Latter-day Saint Faith and Scholarship

Centuries-long speculation continues regarding the circumstances surrounding the death of the Savior. Whether he died sooner than would have been expected, as some scholars believe, or lived longer than expected, statements from the scriptures and modern-day prophets indicate that the Lord died at the exact moment of his choice. According to the Gospels and historical accounts, that moment coincided with the sacrifice of the later of the two daily tamid sacrifices. The tamid had been instituted by Jehovah and symbolized the future atoning sacrifice of the Savior. Each of the other offerings throughout the sacrificial day between the two tamid …

Music Is My Language: Analyzing Autism Acceptance Within Communities, Cielo Bake

Undergraduate Honors Theses

This thesis explores the intersection of music and romanticism, drawing upon the emotional expressionism of Romantic era composers, inspired by Romantic literature, such as Frederic Chopin and Franz Liszt as a vehicle for communication. The ultimate goal was to determine a way to bridge the neurodivergent and neurotypical gaps in connection, enabling a stronger community that values every member of its locale and allows for a sense of belonging. The format for this research is through a performance, comprised of a piano recital of Romantic Era music by Frederic Chopin and Franz Liszt and improvised original music with a speech. …

Optimization Of Mass Spectrometry-Based Methods For Low-Input And Spatial Proteomics, Andikan Jones Nwosu

Theses and Dissertations

Eukaryotic cells are highly heterogeneous. These cells are arranged into different compartments, carrying out separate functions and facilitating biological processes. Proteins are the effector biomolecules targeted to subcellular locations that help fulfill specific tasks in living organisms. Spatial proteomics can help unravel molecularly how protein abundance and localization are altered in cells, which is not feasible in traditional bulk-scale proteomics. To achieve this, our lab has developed a miniaturized sample processing platform called nanoPOTS, reduced separation columns' inner diameter to increase ionization efficiency and concentrate analytes for mass spectrometers and optimized data acquisition modes for increasing proteome coverage in spatial …

The Effects Of Diesel Exhaust Particle Exposure On Adipos Mitochondrial Bioenergetics And Inflammation, Cali Elizabeth Warren

Theses and Dissertations

Fine particulate matter (PM2.5) constitutes a significant component of ambient air pollution that has been implicated in the pathogenesis of metabolic disorders, including insulin resistance and type 2 diabetes. Among PM2.5 constituents, diesel exhaust particles (DEP) are prevalent particulates that infiltrate the bloodstream to drive systemic pathologies. The purpose of this study was to characterize the metabolic response of adipose tissue to DEP. We aimed to provide a comprehensive understanding by exploring mitochondrial bioenergetics, characterizing the inflammatory marker profile, including adipokines, and conducting a detailed histological analysis of adipocytes to provide valuable insights to the evolving understanding of the intricate …

The Pathophysiology Of The Death Of Jesus The Christ, C. Thomas Black

Interpreter: A Journal of Latter-day Saint Faith and Scholarship

Centuries-long speculation continues regarding the circumstances surrounding the death of the Savior. Over the past century, the Savior’s tribulations between the Last Supper and his death on the cross have been scrupulously examined from a medical viewpoint. In this article I review many of these studies and, using current medical acumen, propose additional inferences and explanations based on scriptural, medical, and historical accounts. The evidence suggests that at some point between Gethsemane and his last moments on the cross, the Lord’s body was pushed beyond the limit that a normal mortal could endure. The Lord did, however, endure and completed …

Twitch Chat Advertising: How Live Chat Valence Affects Consumer Advertising Perceptions, Austin W. Camper

Theses and Dissertations

The streaming platform Twitch.tv, is a popular video streaming website where users can watch, communicate, and chat with streamers and other viewers live. Twitch and other live streaming websites typically offer viewers a chat window where the viewer can chat (in real-time) with the streamer and other viewers who are currently watching the stream. Research in live streaming platforms like Twitch and the effects of their various features are novel. The purpose of this study is to analyze how the sentiment of a live chat (positive or negative) and the stated or not stated disclosure of an advertisement posted in …

The Effects Of Ketones On Brain Metabolism And Cognition, Erin Reiko Saito

Theses and Dissertations

The brain is one of the most energetically demanding organs within the human body and is cognitively susceptible to energetic deficits such that the rise in obesity, insulin resistance, and Alzheimer’s disease in recent decades pose a substantial threat to cognitive longevity. The therapeutic efficacy of ketones are well-established in epilepsy and are currently being applied to other disease states. Alzheimer’s disease is characterized by impairments in brain glucose uptake and metabolism in regions relevant to learning, memory, and cognition that progress with the disease. While brain glucose uptake is impaired, ketone uptake is unaltered, potentially enabling ketones to fuel …

A Comparison Of The Vascular Response To Acute Sauna Heating In Young And Middle-Aged Adults, Olivia Kathryn Leach

Theses and Dissertations

BACKGROUND: Age-related declines in endothelial function have been well documented with larger declines observed in middle-aged. Passive heat exposure has been shown to be a promising method to improve vascular endothelial health, with sauna specifically being linked to reduced risk of cardiovascular disease. Increases in blood flow and shear rates associated with heat exposure are often considered to have a major influence on the observed improved endothelial function following heat exposure. The magnitude of these changes in response to sauna have not yet been defined. Therefore, the purpose of this study is to quantify and compare the vascular response to …

We Live In The Olden Days: Reflections On The Importance Of Scientific And Theological Humility, Steven L. Clark

Interpreter: A Journal of Latter-day Saint Faith and Scholarship

Members of The Church of Jesus Christ of Latter-day Saints have a unique perspective on truth. Our knowledge that Salvation likely involves participation in complex eternal activities requiring significantly more understanding than we currently possess naturally leads us to seek truth and, in addition, to seek an understanding of that truth. Under these circumstances, our inability to fully understand many truths, both revealed and discovered, can lead to confusion. A lack of complete understanding of accepted scientific truth generally leads the serious truth-seeker to enhanced investigative and educational efforts without doubting the ultimate veracity of the concept under investigation; we …

“The Gospel Of Intelligence And Culture”: Literature And Literary Instruction In The Twentieth-Century Mia Curriculum, Michael Austin, Rachel Meibos Helps

BYU Studies

In his journal for April 29, 1888, Bishop Orson F. Whitney recorded a curious meeting that he had with an Apostle. “Had a long conversation in the morning with Apostle Moses Thatcher,” wrote Whitney. “He gave me a blessing and set me apart to deliver a lecture on Sunday, June 3rd next, at the Mutual Improvement Conference in the Tabernacle. My subject is Home Literature. I consented to deliver it, though very busy and overworked, at the request of the Authorities.” This remarkable assignment— he was called and set apart to give a speech in the way men at the …

Methemoglobin Formation Via Nitric Oxide And Comparison Of Methemoglobin, Deoxyhemoglobin, And Ferrous Nitrosyl Hemoglobin As Potential Mri Contrast Agents, Roya Ayati

Theses and Dissertations

Gadolinium-based contrast agents (GBCAs) are in widespread use to enhance magnetic resonance angiography images for evaluating vascular pathology. However, there are safety concerns and limitations regarding the use of GBCAs. It has been shown that the magnetic resonance imaging (MRI) signal intensity (T1-weighted images) in some of the brain's tissues is higher for patients who had multiple exposures to GBCAs compared to patients who had never had exposure to GBCAs. This implies that GBCAs are not sufficiently removed from body such that GBCAs may potentially have long-term effects on the human body. These potential safety concerns have led to an …

Improvement Of Ex Vivo Testing Methods For Spine Biomechanical Characterization, Aubrie Lisa Taylor

Theses and Dissertations

This dissertation contributed three main areas to flexibility testing and biomechanical characterization of human spinal segments. The first was a literature review of existing testing methodology, the second examined common spine fixation procedures, and the third developed an improved fixation method. Spine biomechanical characterization is the primary technique for assessing the healthy, diseased, and surgically treated response of spinal tissues. However, despite decades of use, no standard testing protocol or reporting methodology for flexibility testing conditions has been established. As part of the present work, a comprehensive, systematic literature review was performed, and the methods sections of 242 relevant journal …

The Beneficial Effects Of The Gut-Derived Metabolite Trimethylamine N-Oxide On Functional Β-Cell Mass, Emily Suzanne Krueger

Theses and Dissertations

Elevated serum levels of trimethylamine N-oxide (TMAO) were first associated with increased risk of cardiovascular disease (CVD) 10 years ago. Research has since defined that serum TMAO accumulation is controlled by the diet-microbiome-liver-kidney axis. Choline related nutrients are consumed in excess during over-nutrition from a Western diet. The resultant elevated serum TMAO is investigated across various chronic metabolic diseases and many tissue types. While TMAO is most clearly linked to CVD mechanisms in vascular tissue, its molecular effects on metabolic tissues are unclear. Here we report the current standing of TMAO research in metabolic disease context across relevant metabolic tissues …

Disabled Epistemologies: Failures Of Knowledge And Care In Shakespeares's Merchant Of Venice And Othello, Amie Elisabeth Wambach

Theses and Dissertations

The presence of disabled characters like blind Gobbo in The Merchant of Venice and epileptic Othello are handy physical metaphors for the failures of epistemology that occur in both plays. Disability is often construed as a sort of saboteur of knowledge—disability of all kinds inhibiting the ability to perceive the world as an abled person would. But disability also produces a new, necessary sort of knowledge in order to survive and thrive in an unaccommodating world. A disabled epistemology suggests that knowing is contingent on individual, specific experience of the world. Tied to this issue of disabled epistemology is the …

Migrating Genes: Using Adna And Archaeological Data To Explain Migration In The Casas Grandes Region Of Northern Mexico, Meradeth Snow, Michael T. Searcy

Faculty Publications

Migration as an archaeological topic has addressed huge distances, such as the colonization of the Americas, as well as smaller regions, such as the peopling of specific sites. The use of genetics as a medium to enhance our understanding of population movement can be an asset. There are potential pitfalls, however, such as the misrepresentation of DNA ranging across the landscape without human vectors or motivations. Genetic data must be interpreted through the lens of all available data from the site and surrounding region in order to understand how it its into the potential for human migration. These ideas will …

The Role Of The Chaperone Cct In Assembling Cell Signaling Complexes, Nicole C. Tensmeyer

Theses and Dissertations

In order to function, proteins must be folded into their native shape. While this can sometimes occur spontaneously, the process can be hindered by thermodynamic barriers, trapped intermediates, and aggregation prone hydrophobic interactions. Molecular chaperones are proteins that help client proteins or substrates overcome these barriers so that they can be folded properly. One such chaperone is the chaperonin CCT, a large MDa protein made up of 16 paralogous subunits that form a double ring structure. CCT encapsulates its substrates in a central cavity, where they are sequestered and folded, using ATP binding and hydrolysis to drive conformational changes in …

Development Of A 3d Computational Vocal Fold Model Optimization Tool, Austin C. Vaterlaus

Theses and Dissertations

One of the primary objectives of voice research is to better understand the biomechanics of voice production and how changes in properties of the vocal folds (VFs) affect voice ability and quality. Synthetic VF models provide a way to observe how changes in geometry and material property affect voice biomechanics. This thesis seeks to evaluate an approach of using a genetic algorithm to design synthetic VF models in three ways: first, through the development of a computationally cost-effective 3D vocal fold model; second, by creating and optimizing a variation of this model; and third, by validating the approach. To reduce …

Effect Of Water Consumption On Resting Metabolism In Adults, Brittany Leigh Murphy

Theses and Dissertations

This study analyzed the acute effect of water consumption on resting metabolic rate (RMR). It was hypothesized that water would have a small, nonclinically significant effect on RMR. Men and women ages 18–40 years participated in a crossover study in which each participant received a No Water and Water condition (order determined randomly) with a 7-day washout period between each condition. Both conditions began with visual analog scales to gauge hunger and thirst levels, urine spectrometry to quantify hydration status, and height and weight measurements. The No Water condition consisted of a 30-minute rest period followed by 45 minutes of …

Internal Deformation Measurements And Optimization Of Synthetic Vocal Fold Models, Cassandra Jeanne Taylor

Theses and Dissertations

Developing lifelike vocal fold models is challenging due to various associatedbiomechanical complexities. Nevertheless, the development and analysis of improved vocal foldmodels is worthwhile since they are valuable tools for gaining insight into human vocal foldvibratory, aerodynamic, and acoustic response characteristics. This thesis seeks to contribute tothe development of computational and physical vocal fold modeling in two ways. First is byintroducing a method of obtaining internal deformation fields within vibrating synthetic vocal foldmodels; second is by presenting an optimization algorithm coupled with a computational vocalfold model to optimize geometry and stiffness of a synthetic vocal fold model to achieve morerealistic vibration …

Effects Of Exercise On Clinical Couple Interactions, Samantha Karma-Jean Simpson

Theses and Dissertations

Research has shown that exercise has the potential to improve couple relationships. This study contributes to current literature by examining the associations between exercise, its duration, and its intensity and daily clinical couple interactions. Participants were 22 married couples in a treatment-as-usual setting who completed daily diaries about daily behaviors and marital interactions. Multilevel models were run, and results showed that wives who exercised were more likely to report a negative interaction with their husband that day. When wives exercised longer, both they and their husbands were more likely to report positive interactions that day. Interestingly, if husbands exercised longer …

Niccolo Leo Caldararo, Big Brains And The Human Superorganism: Why Special Brains Appear In Hominids And Other Social Animals. Rowman & Littlefield, 2017, Andrew Targowski

Comparative Civilizations Review

No abstract provided.

Faculty Perceptions Of Open Educational Resources Quality By Peer Review, Olga Maria Belikov

Theses and Dissertations

In this paper, 936 faculty free response reviews of open textbooks from the Open Textbook Library were analyzed for content and themes. The reviews were completed by faculty members at institutions in the United States and Canada. The textbooks were evaluated regarding their comprehensiveness, content accuracy, relevance longevity, clarity, consistency, modularity, organization structure flow, interface, grammatical errors, and cultural relevance. The results of the reviews found that the across 9360 comments regarding the quality of open textbooks, of these comments 97.3% reflected adequate or exceptional reviews of the textbooks. Faculty often compared the texts to traditional textbooks and in all …

Fundamental Principles Of Tremor Propagation In The Upper Limb, Andrew D. Davidson, Steven Knight Charles

Faculty Publications

Although tremor is the most common movement disorder, there exist few effective tremor-suppressing devices, in part because the characteristics of tremor throughout the upper limb are unknown. To clarify, optimally suppressing tremor requires a knowledge of the mechanical origin, propagation, and distribution of tremor throughout the upper limb. Here we present the first systematic investigation of how tremor propagates between the shoulder, elbow, forearm, and wrist. We simulated tremor propagation using a linear, time-invariant, lumped-parameter model relating joint torques and the resulting joint displacements. The model focused on the seven main degrees of freedom from the shoulder to the wrist …

Fundamental Principles Of Tremor Propagation In The Upper Limb, Andrew Doran Davidson

Theses and Dissertations

Although tremor is the most common movement disorder, there exist few effective tremor-suppressing devices, in part because the characteristics of tremor throughout the upper limb are unknown. To clarify, optimally suppressing tremor requires a knowledge of the mechanical origin, propagation, and distribution of tremor throughout the upper limb. Here we present the first systematic investigation of how tremor propagates between the shoulder, elbow, forearm, and wrist. We simulated tremor propagation using a linear, time-invariant, lumped-parameter musculoskeletal model relating joint torques and the resulting joint displacements. The model focused on the seven main degrees of freedom (DOF) from the shoulder to …

Diabetes, Insulin Secretion, And Beta Cell Function, Jeffery Tessem

BYU Research Development Office Research Networking Conference

The intricate processes of nutrient metabolism and their biochemical pathways are fundamental to understanding human physiology and health. This research focuses on exploring the biochemical mechanisms underlying nutrient metabolism and how deviations in these processes can lead to metabolic disorders and associated human diseases.