Digital Commons Network^™

B-Hydroxybutyrate Favorably Alters Muscle Cell Survival And Mitochondrial Bioenergetics, Brian Parker, Benjamin Bikman

Journal of Undergraduate Research

The growing worldwide incidence of obesity and its associated pathologies, like type 2 diabetes, has received much deserved attention. However, despite this attention and substantial research efforts, little meaningful progress has been made in slowing or reversing the growing cost and trends of obesity worldwide. As of 2008, almost 10% of medical costs in the United States were incurred due to obesity or other obesity-related diseases,ⁱ with the substantial amount of this cost stemming from the dramatically increased risk of diabetes with excess fat mass.ⁱⁱ According to the US Centers for Disease Control and Prevention, more than one …

Susceptibility Of Mental Disorders: Examining The Comorbidity Of Seasonal Affective Disorder, Nathaniel Wasden

Student Works

This literature review examines the symptoms, theorized causes, and comorbidity of seasonal affective disorder (SAD). Although causes of SAD remain unknown, researchers have observed a common pattern of vitamin D deficiency among patients with SAD. The importance of vitamin D in regulating serotonergic activity has been well documented, including the positive correlation between decreased serotonin levels and increased depressive symptoms. For more than 30 years, researchers have hypothesized that decreased serotonin activity is linked to symptoms of SAD. Furthermore, patients with other mental disorders, including depression, bipolarity, obsessive-compulsive disorder, etc. are likely to experience aggravation of symptoms during peak SAD …

Rapid Biosensor Screening Blood And Urine, Rebecca Whitney Bills, Dr. Bradley Bundy

Journal of Undergraduate Research

Endocrine Disrupting Chemicals (EDCs) have led to worldwide health problems, including cancers, developmental disorders, and reproductive disorders. A recent study estimates that annual health and economic costs caused by EDCs in the European Union is $200 Billion and that the costs are even greater in the US (1). This is largely due to the extensive number of undetected Endocrine Disrupting Chemicals (EDCs) that we come into contact with on a daily basis. EDCs have been found in dietary, environmental, and household chemicals. Despite this only a handful of EDCs have been characterized. The purpose of this project is to optimize …

Toxoplasma Gondii Seropositivity And Substance Use In Us Adults, Bruce L. Brown, Andrew N. Berrett, Shawn D. Gale, Lance D. Erickson, Evan L. Thacker, Dawson W. Hedges

Faculty Publications

The intracellular parasite Toxoplasma gondii (Nicolle et Manceaux, 1908) infects humans resulting in acute toxoplasmosis, an infection that in immunocompetent people is typically mild but results in persistent latent toxoplasmosis. In that T. gondii appears to affect dopamine synthesis and because addicting drugs affect midbrain dopamine transmission, latent toxoplasmosis could influence substance use. Using both the third and continuous National Health and Nutrition Examination Surveys from the US Centers for Disease Control and Prevention, we used logistic regression to test for associations between T. gondii seropositivity and subject self-report of having ever used tobacco, alcohol, marijuana, cocaine, heroin, or methamphetamine. …

Gas Detection System For Biomass Cookstove Emissions, Cyra Bishop, Jeffery Smith, Dr. Matthew Jones

Journal of Undergraduate Research

The purpose of this research project is to explore Peruvian social and cultural behaviors that typically prevent successful improved cookstove adoption in resource-limited settings as well as suggest ways to educate locals about the benefits of improved cookstoves. This will be done by constructing a cost-effective, easy-to-use gas-detection sensor system capable of measuring concentrations of harmful gases released from biomass cookstoves typically found in Peruvian communities.

Lack Of Access To Water In Rural Malawi, Marissa Getts

Ballard Brief

Lack of access to clean water affects almost every aspect of a person's life in significant ways, and especially impacts the lives of women and children. Measurements of access to water are often deceiving and paint a limited or inaccurate picture of actual access. Building a water point and appointing a water point management committee are the most common methods of addressing the problem. but both are unsustainable because unattended water points typically break down quickly and most management committees are poorly trained. To sustainably increase access to clean water, people should not just create new water points; they should …

Modeling Vocal Fold Intravascular Flow With Synthetic Replicas, Aaron David Terry

Theses and Dissertations

Communication by voice is foundational in our society and many rely on their voices for their occupations. Voice disorders affect a significant number of individuals each year, and diagnosis and treatment improvements are therefore sought via advancements in voice research. Contained in this thesis is a description of work intended to contribute to vocal fold research by using synthetic, self-oscillating vocal fold replicas to study the impact of replica vibration on perfusion fluid flow through the replica. Methods for manufacturing vocal fold replicas containing imbedded channels allowing for fluid perfusion are discussed. Experimental procedures developed for delivering perfusion fluid to …

Sex Differences In Rhesus Monkeys’ Digit Ratio (2d:4d Ratio) And Its Association With Maternal Social Dominance Rank, Alexander Baxter, Elizabeth K. Wood, Parker Jarman, Ashley N. Cameron, John P. Capitanio, James Dee Higley

Faculty Publications

Prenatal androgen exposure (PAE) plays a pivotal role in masculinizing the developing body and brain, and extreme exposure may contribute to autism, anxiety disorder and schizophrenia. One commonly used biomarker for PAE is the pointer-to-ring-finger digit length (2D:4D) ratio. Although this biomarker is widely used in human studies, relatively few studies have investigated 2D:4D ratio in nonhuman primates, particularly rhesus macaques (Macaca mulatta), one of the most commonly used animals in biomedical research. Thus far, data suggest that sexual dimorphism in 2D:4D ratio may be in the opposite direction in some monkey species, when compared to the pattern …

Advancing Social Connection As A Public Health Priority In The United States, Julianne Holt-Lunstad, Theodore Robles, David A. Sbarra

Faculty Publications

A robust body of scientific evidence indicates that being embedded in high-quality close relationships and feeling socially connected to the people in your life is associated with decreased risk for all-cause mortality as well as a range of disease morbidities. Despite mounting evidence that the magnitude of these associations is comparable to many leading health determinants (that receive significant public health resources), government agencies, healthcare providers and associations, and public/private healthcare funders are slow to recognize human social relationships as either a health determinant or health risk marker in a manner that is comparable to other public health priorities. This …

Nicu Nurses' Suggestions For Improving End-Of-Life Care Obstacles, Renea L. Beckstrand, Rebecca F. Isaacson, Janelle L. B. Macintosh, Karlen E. Luthy, Lacey Eden

Faculty Publications

Background: Neonatal deaths (infants less than 28 days old) account for two thirds (66.7%) of all infant deaths with most occurring in an ICU setting. NICU nurses are frequently involved in end-of-life (EOL) care and face unique obstacles.

Objective: The objective of this study was to obtain NICU nurses’ suggestions for improving obstacles in EOL care in NICUs.

Methods: Suggestions were obtained through mailed survey research in qualitative study design. Returned surveys yielded 121 nurse respondents who gave a total of 138 suggestions.

Results: A total of 10 cohesive themes were identified: (1) environmental design issues, (2) improved communication between …

A Nordic Anomaly: Examining The Establishment Of An Anti-Immigrant Party In Sweden, Louise Paulsen

Undergraduate Honors Theses

This thesis examines the establishment of an anti-immigrant party (AIP) in Sweden. Until recently, Sweden was known as the Nordic anomaly with no AIP in spite of high levels of immigration and high rates of right-wing violence. This has now changed, and the AIP, Sweden Democrats, are rising to popularity in high speed. I examine the causes given for the anomaly up until 2006 and show that a change in these has since created a favorable environment for an AIP to become successful. First, socio-economic cleavages have become less salient through decreasing party loyalty and increasing numbers of party switchers. …

Front Matter, Vol. 78 No. 2

Western North American Naturalist

No abstract provided.

High School Physical Education And Its Effects On Fitness Center Participation After Graduation: A Case Study, David C. Barney, Nathan Kahaialii

Faculty Publications

For those that send off their child into the world, it is hoped they will recall what was taught to them. This applies to high school (HS) physical education (PE) teachers and their students that graduate from HS. The purpose of this case study was to assess current HS PE teachers, fitness club personnel, those that frequent fitness clubs and current HS students regarding HS PE preparing HS students for real world application regarding fitness. Participants from these four groups were interviewed to help better understand the preparation of graduated HS students participating in health clubs. From this case study …

Increasing Water Use Efficiency By Nitrogen Management In Turfgrass, Austin Hopkins, Dr. Neil C. Hansen

Journal of Undergraduate Research

This project identifies turfgrass practices to conserve water by optimizing nitrogen (N) fertilization and irrigation strategies. Turfgrass is the most irrigated crop by area (163,800 km2), accounting for 1.9% of the continental U.S. This causes negative environmental impacts and puts the future of irrigated turfgrass in question due to increasing water scarcity, especially in the western U.S. More information is needed on how to irrigate in droughts as turf provides significant benefits in our environment such as aesthetics, cooling effects, carbon sequestration, and preventing soil erosion.

The Effect Of Repeated Heat Stress On Mitochondrial Protein Content In Human Skeletal Muscle, Amy Twitchell, Robert Hyldahl

Journal of Undergraduate Research

Exercise has been known to improve mitochondrial function and increase its content in muscle. However, those who suffer from certain diseases such as Chronic Obstructive Pulmonary Disease (COPD) and Type II Diabetes often experience concomitant exercise intolerance. In vitro research suggests that the application of a mild heat stress may be sufficient to activate some of the same signaling proteins that become active during exercise, possibly leading to mitochondrial biogenesis in skeletal muscle. However, this has not yet been confirmed to occur in human skeletal muscle. Therefore, the purpose of this study was to investigate the effect of heat therapy …

Prevalence Of House Dust Mites In Low-Income Homes In Utah County, Robert Graul, Dr. James Johnston

Journal of Undergraduate Research

Asthma is the leading chronic disease among children in U.S. Low-income populations, minorities, and children living in poor housing experience more emergency department visits, hospitalizations, and deaths due to asthma that the general population. HDM allergens are linked to the exacerbation of asthma and are found within homes all throughout the United States. Previous studies have shown that HDM exposure is lower in arid and semi-arid climates, such as Utah, but robust data is still lacking. Although HDM thrive in climates more humid than Utah, we have found that they are still present based on certain indoor environmental factors.

Synopsis: A Digital Global Supply Chain, Jonathan Chichoni

Marriott Student Review

No abstract provided.

Predictive Power? Textual Analysis In Mergers & Acquisitions, Philip E. Morgan

Marriott Student Review

Modern corporations utilize mergers and acquisitions as strategies to develop shareholder value today more than ever before, yet the need for understanding firms’ rationale and strategy is critical in predicting post-merger stock performance for all investors. I apply the interpretive power of textual analysis and regression to a corpus of SEC mergers and acquisitions public company filings between 1994-2017. Not only do I challenge the statistically significant correlation between word content and post-transaction abnormal stock returns, but I also characterize the effects of time segments, transaction size, and industry variation across time. As a final application, I consider sentiment analysis …

Design Thinking And The Marriott School, Catherine Gardiner, Madie Neeley, Mat D. Duerden

Marriott Student Review

No abstract provided.

The Power Of Happiness, Sarah R. Romney

Marriott Student Review

This article synthesizes research and psychological principles to explain the impact that one’s attitude can have oneself and others. A positive attitude is contagious and can help one perform better, be more motivated, and earn a higher wage. It can also increase team performance and help others be happy to receive the same benefits. By focusing on their expressions and attitude, people can greatly impact the organizations they are a part of.

Marriott Student Review Volume 2 Issue 2: A Bright Future, Marianna Richardson

Marriott Student Review

In business, opportunities are often determined by passion, drive, and persuasion in delivering a brilliant vision for future opportunities. In this issue of Marriott Student Review, we explore the bright future of the business world. Each article focuses on some aspect of business and the exciting possibilities that lay ahead.

Forensic Science Research Opportunities, Conrad Monson

BYU Research Development Office Research Networking Conference

Forensic Sciences research needs, disciplines, and activity at BYU

Commercial Dance Activism, Keely Song Glenn

BYU Research Development Office Research Networking Conference

Advocating clean air, reduce/reuse/recycle with an emphasis on clean water, and post-partum recovery exercises and accessibility

Epilepsy, Evan Thacker

BYU Research Development Office Research Networking Conference

Areas of interest: Causes and consequences of neurological and cardiovascular diseases

End Matter, Rilley Mckenna, Heidi Herrera

AWE (A Woman’s Experience)

No abstract provided.

Summer Bridge For Student Athletes: A Comparison Of Effects On Special Admit And General Admit Student Achievement, Laura Swee Ong

Theses and Dissertations

This study was an investigation of academic outcomes for student athletes who did or did not participate in an athlete-specific freshman Summer Bridge program in a private Division I university in the western United States. Analysis of data across five years yielded results regarding fall, winter, and cumulative GPA; and progress toward degree for special admit and general admit student athletes. Data indicate significant differences between groups in terms of GPA and progress toward degree for the first year. However, there were no significant main interaction between time and group as measured by differential slopes over time according to group …

Exploration Of Antimicrobial Activity In Natural Peptides And High-Throughput Discovery Of Synthetic Peptides, Emma Kay Dallon

Theses and Dissertations

Despite many medical advances, antibiotic resistant bacteria increasingly plague the modern world, necessitating discovery of new antibiotics. One area of nature that can provide inspiration for antibiotics is antimicrobial peptides. Many of these peptides exist in nature, with some classes that have not been studied or characterized well. One such class is the defensin-like peptides generated by the plant Medicago truncatula as part of their symbiotic relationship with Sinorhizobium meliloti. Nodule-specific Cysteine Rich (NCR) peptides are defined by the presence of multiple cysteines, and regulate the growth of S. meliloti within plant cells. While some of these NCR peptides have …

Alzheimer's Disease And Diabetes: A Transgenic Mouse Model In Behavior, Mri, And Cells, Kevin Sage Steed

Theses and Dissertations

Alzheimer's disease (AD) is the most common form of dementia, afflicting almost 5 million patients in the US, and impacting millions more, financially, physically and emotionally. Coming in as the 6th leading cause of death in the US, and showing no signs of slowing its annually increasing rates, the world is in desperate need of improved understanding of the disease's multifaceted pathogenesis and progression, more accurate forms of detection and diagnosis, and more effective prevention and treatment. While many are focused on the noble pursuit of understanding the genetic contributions to the appearance of the pathological amyloid beta (Aβ)) plaques …

The Effect Of Mechanical Load On Biomarkers Of Knee Joint Inflammation For Individuals Who Are Predisposed To Knee Cartilage Degeneration: An Exploratory Study, Alyssa Evans

Theses and Dissertations

Objective: Physical exercise decreases disability and pain associated with chronic articular cartilage degradation. However, understanding of the pathology is lacking. In this study, the levels of 17 biomarkers of inflammation and cartilage degradation were measured in synovial fluid (SF) before and after a 30-minute run in able-bodied and previously-injured individuals. Materials & Methods: Four able-bodied recreational runners (3 men and 1 woman: 24 ± 2 years, 68 ± 7 kg, and 173 ± 9 cm) and 4 recreational runners who had undergone a unilateral anterior cruciate ligament reconstruction (ACLr) (2 men and 2 women: 23 ± 1 years, 71 ± …

Fluorescent Labeling Of Antibiotic Resistant Bacteria Model Dna, Janice Darko

Theses and Dissertations

Global threats to treatment of bacterial infections due to antibiotic resistance (AR) have been on the rise in recent years. Current diagnostic tests identify bacteria by using blood culture, which takes more than 24 hours. This study focuses on the fluorescent labeling of DNA derived from bacterial AR genes (KPC & VIM) and other model DNAs using oligreen dye (OG) and molecular beacons (MB). A NanoDrop 3300 fluorospectrometer was used to take fluorescence measurements. Linear dynamic range and labeling efficiency were dependent on the following optimized conditions: dilution factor of OG (200 fold), buffer (20 mM Tris HCl, pH 8), …