Digital Commons Network^™

Video Games For The Win: Examining The Net Positive Impact On Emotional, Cognitive, And Social Aspects Of Mental Health In Today’S Youth, James Sanford

Student Works

Video games are becoming an integral part of society, as more than 90% of adolescents play them often, and the industry is growing in revenue every year (Granic et al., 2014). However, many mainstream media outlets portray video games as detrimental to mental health and damaging to cognitive abilities, with initial research into video games initially corroborating such claims and finding correlations to violent behavior (Ferguson, 2020). These early research methods could have been more robust; moreover, focusing on only the negative aspects of gaming research significantly reduced their ability to properly understand gaming’s full impact. Video games typically encourage …

Rage In Chronic Pulmonary Inflammation And Obstetric Complications, Katrina Lynn Curtis

Theses and Dissertations

The receptor for advanced glycation end-products (RAGE) is a transmembrane cell surface protein of the immunoglobulin superfamily that acts as part of both the innate and adaptive immune system. RAGE is highly expressed in lung tissue and is therefore of interest in the pulmonary immune response. Specifically, RAGE mediates several cell-signaling responses such as inflammation and apoptosis. This work sought to elucidate the role of RAGE in the setting of chronic pulmonary irritation such as that found in long-term exposure to secondhand smoke (SHS). This irritation has several shared characteristics with lung diseases such as chronic obstructive pulmonary disease (COPD) …

Prosodic Pitch And Intensity In Autistic Individuals, Cassidy Gooch

Theses and Dissertations

This study is an examination of how prosodic pitch and intensity compare in autistic individuals and neurotypical individuals. Ten-minute recordings of casual conversation were taken and analyzed. Participants included 11 autistic individuals and 11 neurotypical individuals with six males and five females in each group. The Autism Diagnostic Observation Schedule, 2nd Edition (ADOS-2; Lord et al., 2012) prosody rating scale was used to collect a perceptual evaluation of each participan's prosody, and Praat acoustic analysis software was used to collect measures of pitch and intensity over the 10-minute period to investigate how speech characteristics change with conversation partner familiarity. Results …

Stability, Longevity, And Regulatory Bionetworks, Christian N. K. Anderson

Theses and Dissertations

Genome-wide studies of diseases and chronic conditions frequently fail to uncover marked or consistent differences in RNA or protein concentrations. However, the developing field of kinetic proteomics has made promising discoveries in differences in the turnover rate of these same proteins, even when concentrations were not necessarily different. The situation can theoretically be modeled mathematically using bifurcation equations, but uncovering the proper form of these is difficult. To this end, we developed TWIG, a method for characterizing bifurcations that leverages information geometry to identify drivers of complex systems. Using this, we characterized the bifurcation and stability properties of all 132 …

Seeking Connection By Forsaking Self: Associations Of Autonomy And Relatedness With Self-Silencing And Emotional Fusion, Amber A. Price

Theses and Dissertations

Humans innately feel a desire for connection, but in its pursuit, some may inadvertently thwart the very connection they seek. One way this may happen is through forsaking a sense of autonomy in favor of relatedness using behaviors such as self- silencing (stifling the self to preserve a relationship) and emotional fusion (relying on validation from others). To better understand how these four variables—autonomy, relatedness, self-silencing and emotional fusion—function together, I used latent profile analysis to identify classes among US adults in long-term relationships (n = 1065). Separate classes were identified for men and women. I then used the Bolck-Croon-Hagenaars …

Full Issue

Insights: The Newsletter of the Neal A. Maxwell Institute for Religious Scholarship

No abstract provided.

Dinner Completes Nibley Birthday Celebration

Insights: The Newsletter of the Neal A. Maxwell Institute for Religious Scholarship

A dinner to note the completion of the two-volume By Study and Also by Faith: Essays in Honor of Hugh Nibley on the Occasion of His Eightieth Birthday was held on September 7. In attendance were Brother and Sister Nibley, over half of those who contributed articles to the volumes, members of the administration at BYU, and Elder Neal Maxwell of the Quorum of the Twelve.

Nibley's Latest Lectures Now On Audiotape

Insights: The Newsletter of the Neal A. Maxwell Institute for Religious Scholarship

Facsimile #2 of the Pearl of Great Price is an Egyptian hypocephalus. Anciently such documents were placed under the head of a deceased person before burial. In a series of twelve lectures recently sponsored by F.A.R.M.S. and delivered at BYU, Hugh Nibley discussed "what the Egyptians themselves said about the hypocephalus," "what Joseph Smith said about it," and the facsimile's meaning and importance.

New Book Of Mormon Geography Map Available

Insights: The Newsletter of the Neal A. Maxwell Institute for Religious Scholarship

A handsome new wall map suitable for classroom use has been developed by Dr. Michael Preece, a Salt Lake physician and student of the Book of Mormon. It follows the model of geography in John Sorenson's An Ancient American Setting for the Book of Mormon. Dr. Sorenson assisted in the project.

Mechanisms, Evolution, And Rapid Diagnosis Of Carbapenem Resistance, Taalin Shale Hoj

Theses and Dissertations

An estimated 70% of bacterial infections in the United States are resistant to first-line antibiotics. Of these, among the most difficult to treat are highly resistant to carbapenems, an antibiotic class used as a last resort. Septicemia, particularly when caused by a carbapenem-resistant organism, is among the most challenging clinical scenarios to treat, with an overall mortality rate of carbapenem-resistant septicemias 63.8%. Encouragingly, if effective antimicrobial treatment begins within 1-3 hours of septic shock onset, patient survival rates are around 80%. The first section of this work describes a real-time PCR-based assay that when coupled with existing bacteria-blood separation technology, …

Elucidating The Architecture Of The Tclijn Complex That Converts Cysteine To Thiazoles In The Biosynthesis Of Micrococcin, Diana G. Calvopina Chavez

Theses and Dissertations

Thiopeptides are a family of antimicrobial peptides that are characterized for having sulfur-containing heterocycles, and for being highly post-translationally modified. Numerous thiopeptides have been identified; almost all of which inhibit protein synthesis in gram-positive bacteria. These intrinsic antimicrobial properties make thiopeptides promising candidates for the development of new antibiotics. The antimicrobial peptide micrococcin is a thiopeptide that is synthesized by the ribosome and undergoes several post-translational modifications (PTMs). Micrococcin is formed from a precursor peptide, TclE. TclE comprises an N-terminal leader (35-AA) that is crucial for recognition of the PTM machinery, alongside a C-terminal core sequence (14-AA) that undergoes multiple …

The Impact Of Appearance-Related Communication In Families On Female Adolescent Body Image Development, Cambria Siddoway

Family Perspectives

No abstract provided.

Dyadic Coping In The Transition To Parenthood, Sierra Gray

Family Perspectives

The Transition to Parenthood (TTP) is a common transition point for couples that is often associated with declines in relationship satisfaction. There are many changes that take place during this transition that can lead to a variety of stresses such as psychological distress, sexual distress, as well as increases in conflict. Parents likely experience these stressors together, and therefore should implement dyadic coping processes. With partner support and responsiveness, parents can counter damaging psychological outcomes. As partners incorporate empathy and communicate effectively throughout the TTP, they can prevent and improve sexual outcomes. Since partner conflict is very common during this …

More Than Fun And Games: Why Play Matters, Leah Merrill

Family Perspectives

No abstract provided.

Analysis Of Benefits Of Udot's Expanded Incident Management Team Program, Joel Clegg Hyer

Theses and Dissertations

In 2019, the Utah Department of Transportation (UDOT) funded a research study evaluating the performance measures of UDOT's expanded Incident Management Team (IMT) program. The number of IMTs patrolling Utah roadways increased from 13 to 25 between 2018 and 2020. Crash data were collected from the Utah Highway Patrol's Computer Aided Dispatch database and from the UDOT TransSuite database to compare IMT performance measures between the two years and to evaluate the benefits of the expanded IMT program. However, these data were compromised due to the effects of the COVID-19 pandemic. This study collected data for 2022 using the same …

Manipulating And Assaying Chromatin Architecture Around Enhancer Elements In Vivo, John Lawrence Carter

Theses and Dissertations

There are about 20,000 genes in the human genome. The lowly nematode worm, C. elegans, has about the same number of genes. How could two organisms that are so different arise from a similar number of genes? The answer is epigenetics, or the factors that help control when and where genes are expressed. There are many layers that comprise the epigenetic control of genes. One of which is the structure or architecture of chromatin. Chromatin is a complex of DNA and proteins. Histone proteins with DNA wrapped around them form the fundamental component of chromatin, the nucleosome. Chromatin exists in …

Monitoring Brain Region-Specific Control Of Protein Turnover And Concentration Using Proteomics, Rebecca Suzanne Burlett

Theses and Dissertations

Regulation of metabolism is vital to health and lies at the core of many different diseases. The breakdown of metabolisms' regulation within the brain can lead to neurological disease like Alzheimer's Disease (AD). AD is known to affect brain regions responsible for memory and memory processing like the hippocampus and entorhinal cortex. The regulation of these regions' protein quality, synthesis, and degradation deviate from 'normal' or 'healthy' levels when AD is happening. It is known there is a breakdown of regulation in those regions; however, little is known about the specifics of regulation in healthy brains regions or how it …

Dispensing With Humans In Human-Computer Interaction Research, Courtni L. Byun

Theses and Dissertations

Machine Learning models have become more advanced than could have been supposed even a few years ago, often surpassing human performance on many tasks. Large language models (LLM) can produce text indistinguishable from human-produced text. This begs the question, how necessary are humans - even for tasks where humans appear indispensable? Qualitative Analysis (QA) is integral to human-computer interaction research, requiring both human-produced data and human analysis of that data to illuminate human opinions about and experiences with technology. We use GPT-3 and ChatGPT to replace human analysis and then to dispense with human-produced text altogether. We find GPT-3 is …

Inconsistent Correlation And Momenta: A New Approach To Portfolio Allocation, David Kercher

Theses and Dissertations

Correlated stocks should, in equilibrium, have correlated momenta, but in practice momenta do not always correlate. We use short-term inconsistencies between correlations and momenta to predict price corrections, produce more meaningful investment indicators, and improve upon accepted investing strategies. In particular, our approaches integrate inconsistencies within an entire security class rather than relying only on individual or pairwise security data. We use this theory to improve upon not only the standard momentum portfolio but also Pair Trading and Momentum Reversion methods. This results in three strategies for portfolio allocation that outperforms overlying indices and market benchmarks by 5%-10% in annual …

Cell Of Origin Identification Using Methylation Signatures From Seminal Cell-Free Dna And Heterogenous Cellular Mixtures, Ryan Barney

Theses and Dissertations

Infertility is an issue for approximately 12% of couples attempting to have a child. Of this group, 50% of the cases are due to male factor infertility. There are many reasons for decreased fecundity in men, but there remains 10% to 15% of infertile men that are diagnosed with the most severe form of infertility, non-obstructive azoospermia (NOA). A diagnosis of NOA implies the lack of sperm cells in the ejaculate with no physiological reason. The current diagnostic test and treatment consist of microscopic examination of seminal fluid and a biopsy to extract any viable sperm from the testis. This …

Feasibility Of An Abstract Verb Naming Treatment For Aphasia, Dallin J. Bailey, Lisa Bunker, Julie L. Wambaugh

Faculty Publications

Purpose

Verb production impairments in aphasia have important implications for sentence production and communication in general. Verbs with low concreteness may be especially important for certain functional uses, and yet limited data regarding their response to treatment are available. This study was designed to examine a novel behavioral treatment approach to improve low concreteness verb naming in persons with aphasia.

Method

Three persons with nonfluent aphasia participated in a single-subject experimental design research study examining the feasibility of the novel treatment. The treatment was based on approaches that target the verb as the central node of meaning during sentence construction. …

Developing 3d Printed Integrated Microfluidic Devices For Microchip Electrophoresis Separation Of Preterm Birth Biomarkers, Joule E. Esene

Theses and Dissertations

Preterm birth is a global health challenge and the leading cause of neonatal mortality. Each year, about 15 million babies are born preterm globally. Traditional tools that have been exploited for the detection of preterm birth biomarkers are expensive, time consuming, or lack multiplexing capabilities. The work described in this dissertation highlights techniques developed to detect preterm birth biomarkers rapidly and accurately in the effort to mitigate preterm birth risk. In this dissertation, I first demonstrated the use of stereolithography digital light processing-based 3D printing and microfluidics for the development of microfluidic devices that had microvalves for fluid control. I …

A Definition Of Reliable Water Supply For Public Water Systems, Easton Hopkins

Theses and Dissertations

"Reliable water supply" does not have a universal definition in Utah, or the Western United States, where water resources are limited and such a definition would be especially useful. Utah's three water agencies and 500 public water systems have no consistent method to define, evaluate, and report it, potentially leading to an inability to meet regulatory water demands. We propose a unified definition of reliable water supply for Utah's public water suppliers that can also be used elsewhere. The qualitative definition we propose is necessary to precede quantitative evaluations, set policy, and provide consistency to water resources management in Utah. …

Nano Composite Piezo-Responsive Foam Enabled Pressure Mapping, Jake Duane Sundet

Theses and Dissertations

Pressure injuries cause pain both physically and financially. By creating a comfortable pressure mapping system, pressure injuries can more easily be prevented, and a large expenditure avoided. Nano composite piezo-responsive foam (NCPF) is an inexpensive foam that can be used to measure a static load while still providing a comfortable interface. As NCPF compresses, the impedance changes, correlating to a change in pressure. Optimizing electrode geometry is needed to take full advantage of the impedance change NCPF incurs upon deformation. To optimize electrode geometry, a design of experiment was performed which concluded that a one square inch area of interlaced …

A Novel Application Of Spinning Disk Technology To Collect Plasma From Whole Blood Prior To Quantifying Plasma Rna, Naomi Rapier-Sharman, Mae-Lynn L. Hutchinson, Carlos M. Moreno, Abraham Quaye, Brian D. Poole, K. Scott Weber, William G. Pitt, Brett E. Pickett

Faculty Publications

The spinning disk technology has previously been utilized to isolate bacterial components from blood in hours instead of days. We hypothesized that this platform could be applied as an alternative approach to isolating plasma RNA from a whole blood sample. We consequently tested the efficacy of the spinning disk technology to extract plasma from whole blood upstream of RNA isolation and analysis. To do so, we collected plasma using either the spinning disk or the typical two-spin centrifuge method. We found that the spinning disk method results in significantly more hemolysis during collection than the conventional two-spin centrifuge method. However, …

Full Issue

Swiss American Historical Society Review

No abstract provided.

The African Education Of Violaine Idelette Junod, Keith Snedegar

Swiss American Historical Society Review

May 11 of this year would have been the one-hundredth birthday of Violaine Idelette Junod, a remarkable if not well-known member of a celebrated Swiss missionary family. Born and raised in Africa, Violaine was nonetheless imbued with a thoroughly European worldview. To truly confront the realities of modern Africa, Junod would have to experience, through a long career as a social activist and educator, the harsh legacies of colonialism, poverty, and civil unrest across the continent of her birth. This she did with great tenacity and, finally, deep personal insight. The following is a sketch of an African education that …

A Swiss Calendar Maker In Colonial America: The Life And Work Of Johannes Tobler (1696-1765) Between Appenzell Ausserrhoden And South Carolina, David Aragai

Swiss American Historical Society Review

Johannes Tobler was a self-taught mathematician and astronomer. He published the first “Appenzeller Kalender” in 1721, an astronomical almanac in the style of the then popular genre. This almanac was the first periodical of Appenzell Ausserrhoden and is still issued today. After Tobler became a magistrate in the council of Appenzell Ausserrhoden, he found himself on the losing side of an internal conflict, called the Landhandel. As a result, he emigrated with his family and nearly two hundred citizens of Switzerland to South Carolina in 1736/37. After several years in which he built a new livelihood and became Justice of …

In Memoriam: Dr George “Qingzhi” Zhao, Hana Kim

Journal of East Asian Libraries

No abstract provided.

Unique Collections And Digital Humanities Initiatives: From Concept To Creation–Exploration And Practice At The University Of Pittsburgh Library System, Edward Galloway, Haihui Zhang

Journal of East Asian Libraries

This report provides a overview of the Digital Humanity projects undertaken by the East Asian Library within the University of Pittsburgh Library System over the past decade. The review encompasses the genesis and original objectives behind initiating these projects, the challenges and difficulties encountered, the procedural aspects of implementation, and the insights gained.