Digital Commons Network^™

Encapsulation And Release Of Calcein From Herceptin-Conjugated Eliposomes, Mah Noor Zafar, William G. Pitt, Ghaleb A. Husseini

Faculty Publications

Achieving an optimal therapeutic level is crucial in effectively eradicating cancer cells during treatment. However, conventional chemotherapy-associated systemic administration of anticancer agents leads to many side effects. To achieve the desired control over the target site, active targeting of HER2-positive breast cancer cells can be achieved by conjugating liposomal vesicles with Human Epidermal growth factor Receptor 2 (HER2) and inducing release of the encapsulated drug using ultrasound. To further enhance the delivery efficiency, nanoemulsion droplets exhibiting responsiveness to low-frequency ultrasound are encapsulated within these lipid vesicles. In this study, we prepared four different liposomal formulations, namely pegylated liposomes …

Full Issue

The Thetean: A Student Journal for Scholarly Historical Writing

No abstract provided.

Faithful In Friendship: Dietrich Bonhoeffer's Self-Perception As Portrayed By His Relationship With Eberhard Bethge, Greer Bates

The Thetean: A Student Journal for Scholarly Historical Writing

Shortly before Christmas 1943, Dietrich Bonhoeffer sat at the desk in his cell at Berlin's Tegel Prison to pen letters to the loved ones he left behind when the Gestapo arrested him on charges of conspiracy against the Fuhrer. Bonhoeffer recently passed the eight-month mark since his arrest, and he had given up hope of being released to his family in time for the holiday. "There's probably nothing for it but to write you a Christmas letter now to meet all eventualities," he opened a note to his parents, explaining that he had accepted the fate of not spending Christmas …

Obrajes, Andean Workers, And The Spanish Elite: Hegemony And Hierarchy In Peru's Late-Colonial Era, Taylor Cozzens

The Thetean: A Student Journal for Scholarly Historical Writing

In colonial Peru, Spanish-Indian relations revolved around taxes and tribute labor. Regarding the latter, the Spanish elite required the conquered Andean communities to provide workers for colonial industries. Though the Spanish-whether born in Spain (Peninsular) or in the New World ( Criollo or Creole)- had the upper hand in this arrangement, they did not have total control. The relationship was, rather, one of hegemony. Historian Florencia Mallon described hegemony as a "dynamic or precarious balance, a contract or agreement [that] is reached among contesting forces." In Peru, tribute labor facilitated this kind of balance. Specifically, the Indians respected Spanish rule …

Preface, Elise Petersen Lipps

The Thetean: A Student Journal for Scholarly Historical Writing

One year ago, Cameron Nielsen approched me at the History Department Banquet with an interesting inquiry. We had seldom crossed paths, so his question surprised me: was I interested in replacing him as the Thetean's editor in chief? Flattered, but preoccupied with an upcoming presentation in Philadelphia and a summer internship in the English Lakes, I agreed to consider his offer with little ambition to follow through. How appreciative I am that Cameron persisted and passed my name to Dr. Jeff Hardy, who extended me a second invitation shortly thereafter. I write this prologue one year later with a grateful …

The Implementation Of A Mass Casualty Simulation For Utah County Search And Rescue, Nathan Smart, Scott Summers, Craig Nuttall, Janelle Macintosh

Student Works

Background: Utah County’s population growth has precipitated a surge in search and rescue (SAR) missions, including mass casualty incidents (MCIs) in remote wilderness areas. Recognizing the critical need for enhanced preparedness in MCI response, Utah County SAR sought assistance to expand the training of their medical team in MCI. This project was initiated with the primary objective of augmenting the knowledge and readiness of Utah County SAR volunteers for managing MCIs in wilderness settings.

Methods: A one-day, on-site MCI simulation event designed by the project team was held at Rock Canyon, Provo, UT, on June 24, 2023. Focused …

Marriage And Family Therapists' Perspectives Of Working With Couples Impacted By Aphasia: General Perceptions And Response To Relationship-Centered Communication Partner Training, Madison Rae Christensen

Theses and Dissertations

The psychosocial needs of couples impacted by aphasia are often unmet. Sixty-one marriage and family therapists' (MFTs) experiences, perceived knowledge, confidence, comfort, and barriers in working with couples impacted by aphasia, and their interactions with speech-language pathologists (SLPs) were investigated using survey methodology. All MFTs were licensed, practicing in the US, and had at least 3 years of experience. Participants completed the following in order: (a) a pre-intervention survey, (b) one of two intervention conditions, and (c) a post-intervention survey. Twenty-eight respondents were randomly assigned to an education-alone intervention and 33 respondents were assigned to an education plus Relationship-Centered Communication …

Rfi Mitigation And Discrete Digital Signal Processing Rfsoc Algorithm Implementations For Radio Astronomy And Wideband Communication Systems, Devon Christopher Ward

Theses and Dissertations

Due to the massive increase of active transmitters broadcasting over wideband frequencies, such as 5G wireless systems, LEO/MEO satellites, satellite constellations, and the increase of IoT devices in the average home, the radio frequency spectrum is becoming more and more congested by interference. Passive receivers face additional challenges due to the growing use of wideband frequency transmissions aimed at boosting communication system throughput. As a result, passive receivers must adopt more robust and intricate techniques to mitigate radio frequency interference. A proposed RFI removal system, known as the true time delay Hadamard projection algorithm, has been introduced in previous work …

Drug Modification Of Synaptic Plasticity At The Inhibitory Synapses Involving Gaba Neurons In The Ventral Tegmental Area, Jie Wu

Theses and Dissertations

The neurobiological underpinnings of substance use disorders (SUDs) involve complex alterations in synaptic plasticity within the mesolimbic dopamine system, particularly within the ventral tegmental area (VTA). While dopamine neurons in the VTA are extensively studied in addiction research, less attention has been given to the plasticity exhibited by VTA GABAergic neurons, despite their established regulatory role in modulating dopamine cell activity. Building upon the ground-breaking work of Bocklisch et al. (2013), we investigated the plasticity at the GABAergic to VTA GABA neuron (VTA GABA-to-GABA) synapse utilizing whole-cell electrophysiology in GAD67 GFP knock-in mice. Our findings revealed an exceptionally rare duo-plasticity …

Two Sides Of The Same Coin Or Two Different Coins? The Differential Predictors Of Casual And Committed Sex, Carson R. Dover

Theses and Dissertations

The purpose of this paper is to analyze potential predictors of accumulating casual vs. committed sexual partners in emerging adulthood. Using a large, national sample of emerging adults in the United States, I examined how alcohol use and attachment orientation differentially predicted accumulating casual and committed sexual partners. I found that higher anxious attachment positively predicted the number of committed sexual partners, while higher avoidant attachment negatively predicted the number of casual sexual partners. I also found that alcohol use positively predicted both the number of casual and committed sexual partners emerging adults accumulated. Further, I tested the strength of …

Transformational Experiences And Decision-Making Processes: Factors Influencing The Choice Of College Major, Ashley Hunsaker

Undergraduate Honors Theses

This thesis examines the influence of transformational experiences on decision making when it comes to choosing one’s major. Participants attended a one-on-one interview with the primary researcher where questions were asked about how they chose their major and how much they enjoy it. Participants were given the chance to tell stories about how they discovered their major and how they decided to pursue it. Results suggested that transformational experiences, internal and external factors, and mentorship led students to choose and stick with a major where they felt a sense of belonging and “fit.” When belonging and perceived fit were not …

The Impact Of Online Orientation Activities In A Blended New-Student Orientation Modality On Social Connectedness, Pamela Potoma Smalley

Theses and Dissertations

Transitioning from high school to college has been a challenge for most students. The inability to make successful transitions has affected students' ability to integrate and graduate from college. Higher educational institutions look to programs such as new-student orientations to support students as they learn to navigate their new academic (and for many, new living) environments. The COVID-19 pandemic changed how new-student orientation worked as all traditional institutions switched completely to online orientation activities from completely in-person activities. As institutions emerged from the aftermath of the pandemic, they implemented blended new-student orientation modalities consisting of both online and in-person activities. …

Prosodic Speech Rate, Utterance Duration, Interruption Rate, And Turn-Taking Latency In Autistic And Neurotypical Adults, Grace Madeline Bell

Theses and Dissertations

The purpose of this study was to examine the following prosodic elements: speech rate, turn-taking latency, number of interruptions, and utterance duration across two groups' neurotypical and autistic young adults. Furthermore, the end goal of this study is to help provide a baseline and clinical application of prosodic differences between autistic and neurotypical adults. Speech samples were collected from 11 neurotypical and 11 autistic young adults from the ages of 18-26. Speech samples were recorded responses from a 10-minute interview between two research assistants and the autistic or neurotypical individual. Using Praat software, speech samples were analyzed and used to …

Digital Performance Management: An Evaluation Of Manufacturing Performance Management Andmeasurement Strategies In An Industry 4.0 Context, Nathaniel David Smith

Theses and Dissertations

Manufacturing management and operations place heavy emphasis on monitoring and improving production performance. This supervision is accomplished through strategies of manufacturing performance management, a set of measurements and methods used to monitor production conditions. Over the last thirty years the most prevalent measurement of traditional performance management has been overall equipment effectiveness, a percentile summary metric of a machine's utilization. The technologies encapsulated by Industry 4.0 have expanded the ability to gather, process, and store vast quantities of data, creating opportunity to innovate on how performance is measured. A new method of managing manufacturing performance utilizing Industry 4.0 technologies has …

Potential For Climate-Based Financing Of Watershed Management To Restore Streams And Improve Water Quality Following A Wildfire: A Case Study Of The Provo River Watershed, Braxton Wayne Porter

Theses and Dissertations

Following wildfires, water quality in forested watersheds is prone to degradation, impacting drinking water treatment and causing increased emissions due to additional energy consumption. We explore the potential for climate-based financing to support wildfire mitigation and watershed restoration and thereby reduce potential water treatment energy demand within the Provo River watershed of Utah, USA. Pre- and post-wildfire erosion and water quality in the Provo River is modeled using GeoWEPP. Energy data from the Don A. Christiansen drinking water treatment plant in the watershed and related literature data are used to estimate the increase in energy use for treating degraded water. …

Full Issue

The Thetean: A Student Journal for Scholarly Historical Writing

No abstract provided.

Angles And Angels: Political Unity And Spiritual Identity In Anglo-Saxon England, Susannah Morrison

The Thetean: A Student Journal for Scholarly Historical Writing

The development of nationalism in Europe is a contested process, and most historians conclude that nationalist sentiments did not arise in the shattered remnants of the Western Roman Empire until the twelfth century. However, a national consciousness developed in England long before this date. Although it was a fundamentally abstract concept, largely limited to the intellectual domain of the highly educated elite, English national identity in the Anglo-Saxon period was a vibrant and powerful cultural force. Memorably articulated by the Venerable Bede in the eighth century, this proto-national sentiment identified the Angles-the Germanic tribes who had invaded and occupied Britain …

"The Voice Of The People, And Not The Voice Of This House": Legislative Instructions In The Atlantic World And The Irish Struggle For Free Trade, 1779-1780, Ian Mclaughlin

The Thetean: A Student Journal for Scholarly Historical Writing

In 1771, on his way to London to lobby for the American cause, Benjamin Franklin visited the city of Dublin. While there, he visited with several members of che Irish Parliament, especially chose who had their own gripes with British imperialism. "I found [the Irish Patriot Party] disposed to be friends of America," he wrote of che experience to a friend, "in which disposition I endeavored to confirm chem, with the expectation chat our growing weight might in time be thrown into their scale, and, by joining our interest with theirs, might be obtained for chem as well as for …

"Always Leading Out In That Which Is Great And Good": Mormon Women's Perspective Of Women's Rights Fifty Years After Suffrage, Ashley Anderson Webb

The Thetean: A Student Journal for Scholarly Historical Writing

On a cold Thursday in eartly February 1920, newly enfranchised women from across che nation huddled together in Chicago for a seven-day-long Golden Jubilee. The anticipated passage of the Nineteenth Amendment lay only three scares' ratification and half a year away. That same Thursday, women in Utah looked back half a century co 12 February 1870, when che Utah Territory granted its women the right co vote. While reflecting on their own history, Utah's women also case their eyes outward, joining their sisters throughout the US who looked forward co the future of nationwide suffrage. Many prominent female leaders of …

"No Nation More Tenacious Of Its Past" National Historical Memory In Lnterwar Scotland, 1920-1934, Susannah Morrison

The Thetean: A Student Journal for Scholarly Historical Writing

Looking back over the last claendar year at the end of 1929, one Glasgow newspaper concluded, "Certainly no year within the memory of any living Scot has witnessed so much heart-searching. Never before has there been so much airing of the question: what is wrong with Scotland?" The question might as well have been posed about the entire decade of the 1920s. Scotland emerged from the Great War essentially demoralized, with a devastated industrial sector, an influx of Irish immigration, and a flood of mass Scottish emigration to Canada, Australia, and New Zealand. Facing this onslaught of postwar domestic problems, …

Determining The Role Of Noncoding Insertion And Deletion Mutations In Lung Cancer, Zachary Everton, Matthew H. Bailey

Library/Life Sciences Undergraduate Poster Competition 2024

Background

● Cancer is a disease in which cells grow and divide at an uncontrolled rate and cause damage to surrounding tissue and is caused by mutations in the cells’ DNA.

● Though some cancer-causing mutations are inherited from parents, most cancer-causing mutations emerge over the course of a person’s life and are localized to the tumor. These localized mutations are also known as somatic mutations.

● The human genome is over 6.27 billion base pairs long and cannot be read from end to end; instead it is read in small pieces that are aligned to best-matching sequences in the …

Cell Death, Inflammation, And Extracellular Vpr In The R77q Mutation Of Vpr In Hiv-1, Amanda Carlson, Brad K. Berges, J. Brandon Lopez

Library/Life Sciences Undergraduate Poster Competition 2024

One potential target for therapeutic treatment of HIV-1 is Viral Protein R (Vpr), an accessory protein encoded by the HIV-1 genome. Vpr plays an important role in pathogenesis and replication for HIV and is involved in transcription, the pre-integration complex, cell cycle arrest, and cell death via apoptosis. Mutations in this protein dramatically impact the rate of AIDS progression compared to the wild type (WT) version of Vpr. The Vpr polymorphism R77Q is associated with the Long Term Non Progressor (LTNP) phenotype. Regular AIDS onset is 5-7 years for WT virus and 10 or more years for R77Q. These differences …

The Effect Of Epicatechin And Its Microbial Metabolites On Differing Pathways Of Beta-Cell Death In Type I And Type Ii Diabetes, Aubree Bench, Jeffery S. Tessem

Library/Life Sciences Undergraduate Poster Competition 2024

The pathogenesis of type 1 (T1D) and type 2 diabetes (T2D) is associated with progressive beta-cell death and loss of insulin secretion, making functional betacell mass preservation a priority in the treatment of diabetes. T1D beta-cell death is primarily mediated by autoimmune exposure of beta-cells to proinflammatory cytokines such as IL-1b, TNFa, and IFNg (1, 2). Beta-cell loss in T2D, however, is characterized by damage caused by a destructive metabolic state of persistent hyperglycemia and elevated free fatty acid (FFA) levels (2, 3). Our lab has shown that the monomeric flavonoid epicatechin and its metabolites hippuric acid, homovanillic acid, and …

Understanding The Impact Of Post-Translational Modifications On Nucleosome Positioning, Bronwyn Kennington-Nitz, Steven Johnson, Sophie Lo, Michael Mann, David Bates

Library/Life Sciences Undergraduate Poster Competition 2024

The placement of histones along DNA is known to be a significant factor in determining gene expression in eukaryotic cells, with post-translational modifications (or PTMs) helping modulate gene expression by acting as an intermediate to other factors. Using the Lys>Gln and Acetyl-Lys mutations of H3, our working hypothesis is that acetylation will decrease the overall strength of positioning, and that mutations will have an identical or nearly identical effect on nucleosome positioning.

Understanding Refractory Status Epilepticus With Novel Hd-Mea Technology, Isaac Stubbs, Ryley Parrish, Melissa Blotter, Max Holmes, Skyler Russell

Library/Life Sciences Undergraduate Poster Competition 2024

3rd Place Oral Presentation

Status Epilepticus (SE) is a severe medical condition marked by continuous seizures lasting over 5 minutes. When SE becomes resistant to anticonvulsant drugs, the condition is known as Refractory Status Epilepticus (RSE), which lacks effective treatments and has a mortality rate of 38%. RSE lacks effective treatments partially due to our limited understanding of the mechanisms that lead to patient antiepileptic drug resistance.

Solving The Hiv Enigma: Investigating Mutant Long-Term Non-Progressor Vpr Strands, Megan Knight, Bradford Berges

Library/Life Sciences Undergraduate Poster Competition 2024

Different variants of HIV:

➢ Rapid Progressor: aggressive symptoms, quick progression into AIDs

➢ Wild-Type: regular symptoms, regular progression into AIDs

➢ Long-Term Non-Progressor: little-

Jaspine B And The Sea Sponge That Fights Cancer, Jack Davis, Jared Barrott, Adriene Pavek, Farjana Afrin, Sameena Mateen, Brendon Meldrum, Rocio Rojas, Pamela Diaz, Megan Condie, Ali Aghazadeh-Habashi, Srinath Pashikanti

Library/Life Sciences Undergraduate Poster Competition 2024

Jaspine B is a natural marine product, derived from the sea sponge, Jaspis, found in some tropical climates. Jaspine B has been shown to be an effective treatment in some cancers with an upregulation of sphingomyelin synthase. This research aimed to understand the effects of Jaspine B on synovial sarcoma, and investigate its potential to be used as targeted treatment in other cancers that have an upregulation of sphingomyelin synthase

Ivermectin Activates Striatal Cholinergic Interneurons To Enhance Dopamine Release, Tyler Love, Jordan Yorgason, Hillary Wadsworth, Alicia Warnecke, Joshua Barlow, Emma Steimle, Joakim Ronström, Pacen Williams, Christopher Galbraith, Jared Baldridge, Michael Jakowec, Daryl Davies

Library/Life Sciences Undergraduate Poster Competition 2024

• The substantia nigra compacta releases dopamine into the dorsal striatum, a brain region associated with movement and motivation

• Cholinergic interneurons in the dorsal striatum can directly cause dopamine release

• IVM is a known positive allosteric modulator of P2X4 receptors as well as nicotinic

• acetylcholine receptors

• Ivermectin is known to affect many dopamine linked behaviors, but no studies have been conducted to determine if Ivermectin is able to modulate dopamine release

Is Edna Concentration In Staphylococcus Aureus Biofilm Affected By Nanotube Coating?, Brooklyn Z. Jones, Bradford K. Berges, Lucy C. Bowden

Library/Life Sciences Undergraduate Poster Competition 2024

1st Place Oral Presentation

• ~30% of artificial joint failure is caused by infection1

• 80-100% of patients who receive external fixator pins will experience an infection2

• Most of these infections are caused by Staphylococcus aureus

• S. aureus forms biofilms (surface-associated collections of bacteria) that are extremely difficult to treat

• eDNA provides structure and protection to the biofilm

In Search Of Super-Scents For Carnivore Attraction, Megan Doxey

Library/Life Sciences Undergraduate Poster Competition 2024

Find chemical scents that are more effective at alluring North American predators than what is commercially available, then isolate the scent’s chemical structure to create better trapping lures.