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The Dna Methylation Landscape Of Five Pediatric-Tumor Types, Alyssa C. Parker, Badí I. Quinteros, Stephen Piccolo Jun 2022

The Dna Methylation Landscape Of Five Pediatric-Tumor Types, Alyssa C. Parker, Badí I. Quinteros, Stephen Piccolo

Faculty Publications

Fewer DNA mutations have been identified in pediatric tumors than in adult tumors, suggesting that alternative tumorigenic mechanisms, including aberrant DNA methylation, may play a prominent role. In one epigenetic process of regulating gene expression, methyl groups are attached at the 5-carbon of the cytosine ring, leading to 5-methylcytosine (5mC). In somatic cells, 5mC occurs mostly in CpG islands, which are often within promoter regions. In Wilms tumors and acute myeloid leukemias, increased levels of epigenetic silencing have been associated with worse patient outcomes. However, to date, researchers have studied methylation primarily in adult tumors and for specific genes—but not …

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Controlled Pre-Wetting Of Spread Powder And Its Effects On Part Formation And Printing Parameters In Binder Jetting Additive Manufacturing, Colton G. Inkley Jun 2022

Controlled Pre-Wetting Of Spread Powder And Its Effects On Part Formation And Printing Parameters In Binder Jetting Additive Manufacturing, Colton G. Inkley

Theses and Dissertations

Binder jetting is an additive manufacturing process that layer by layer builds a 3D model by selectively binding regions of powder using binder deposited though an inkjet printhead. The process offers several advantages over other additive manufacturing processes including fast build rates, vast material selection, decreased cost, and part resolution. The main disadvantage of binder jetting is poor mechanical properties, stemming from a poor understanding of the process physics. Porosity in final parts is not uncommon, but there is little understanding of where the porosity originates. The purpose of this thesis is to report the investigation of increased powder bed …

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Gas Phase Techniques For The Study Of Biomolecular And Supramolecular Structures And Chemistry, Andrew J. Arslanian Jun 2022

Gas Phase Techniques For The Study Of Biomolecular And Supramolecular Structures And Chemistry, Andrew J. Arslanian

Theses and Dissertations

This dissertation expounds on the investigations of the structure and chemistry of peptides and supramolecular host-guest systems in the gas phase. These investigations used two different kinds of analytical instrument: Fourier transform ion cyclotron resonance mass spectrometry (FTICR-MS) and ion mobility mass spectrometry (IM-MS, IMS). These investigations were complemented by chemical modeling. The FTICR was used to radially trap ions with its 4.7 T magnet, which allowed the ions to undergo sustained off-resonance irradiation collision-induced dissociation (SORI-CID). A subsequent event then measured the collision cross sections (σ) of the targeted precursor ion and one of the selected product ions. These …

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The Effect Of Family Language Policy On The Bilingual Accent Acquisition Of Spanish Heritage Speakers In The United States, Breeahna D. H. Harvey Jun 2022

The Effect Of Family Language Policy On The Bilingual Accent Acquisition Of Spanish Heritage Speakers In The United States, Breeahna D. H. Harvey

Theses and Dissertations

“Family language policy” (FLP) is the accepted term for the field of study of the explicit planning and practices concerning language within a family unit in a home. Previous research has shown that FLP aids in the bilingual acquisition of a child (DeCapua & Wintergerst 2009; Kayam & Hirsch 2014; King, Fogle, & Logan‐Terry 2008; Li 1999; Oh; Schwartz 2008). However, there has been little research providing answers to whether FLP has a direct influence on language maintenance in adulthood, especially whether they acquire and maintain a native or native-like accent in both languages. The purpose of this study is …

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Autoignition Temperatures Of Pure Compounds: Data Evaluation, Experimental Determination, And Improved Prediction, Mark Edward Redd Jun 2022

Autoignition Temperatures Of Pure Compounds: Data Evaluation, Experimental Determination, And Improved Prediction, Mark Edward Redd

Theses and Dissertations

The Design Institute for Physical Properties (DIPPR) maintains the DIPPR 801 database for the American Institute of Chemical Engineers. Autoignition temperature (AIT) is one of the properties included in the database and is the focus of this work including improvement of the overall state of AIT in the database. Phenomena related to AIT as well as the relevant literature are reviewed. Likewise, the database is presented to respond to significant misuse of the DIPPR 801 database in the literature. The database is evaluated, respecting AIT, as a whole to show where improvement is needed. An experimental study of minimum autoignition …

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Demonstration Of A Transient Hot Wire Measurement System Towards A Carbide-Based Sensor For Measuring The Thermal Conductivity Of Molten Salts, Peter Charles Kasper Jun 2022

Demonstration Of A Transient Hot Wire Measurement System Towards A Carbide-Based Sensor For Measuring The Thermal Conductivity Of Molten Salts, Peter Charles Kasper

Theses and Dissertations

This thesis documents research done for a transient hot wire system that will be used in future thermal conductivity measurements of molten salts. Research done with molten salts have been limited because of erroneous measurement capabilities, but the current research strives to introduce a new technique to accurately record thermal conductivity over a wide range of temperatures. This work follows up on past transient hot wire researchers whose designs and tests produced an instrument that can measure the thermal conductivity of molten metals up to 750 K. The transient hot wire (THW) technique has been selected to be used in …

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Factors In Word-Final /T/ Reduction And Deletion In German, Kellie C. Busath Jun 2022

Factors In Word-Final /T/ Reduction And Deletion In German, Kellie C. Busath

Theses and Dissertations

Sound reduction and deletion have been studied across many languages for some time. Usage-based approaches suggest that the more often a word is used, the more likely it is that some of the sounds are reduced. Phonetic environment, stress, and speech rate have all been studied as reasons for sound reduction or deletion. Most recently, frequency in reducing context (FRC) has been included when studying sound reduction and deletion. FRC in this thesis measures the portion of word tokens of a given word type that are followed by a reducing context. This thesis focuses on word-final /t/ reduction and deletion …

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Effects Of An External Oscillation Device On Phonation Threshold Pressure (Ptp), Brittany Tiffany Jones Jun 2022

Effects Of An External Oscillation Device On Phonation Threshold Pressure (Ptp), Brittany Tiffany Jones

Theses and Dissertations

The purpose of the present study was to examine the effects of external laryngeal vibration on voice function. The current study was based on a recent pilot study using silicone vocal folds that demonstrated a decrease in phonation threshold pressure (PTP; cmH2O) when an external oscillation was applied to the vocal folds. Using a within-subjects experimental design, a custom external oscillatory device was fitted to the posterior portion of 12 excised pig larynges using a traditional benchtop phonation setup. For each larynx, phonation was elicited during 30 repeated trials, including 15 with and 15 without external oscillation. During the phonation …

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District Leaders' Perception Of Multi-Tiered System Of Supports Implementation: A Qualitative Study, Julia E. Facer Jun 2022

District Leaders' Perception Of Multi-Tiered System Of Supports Implementation: A Qualitative Study, Julia E. Facer

Theses and Dissertations

Multi-Tiered System of Supports (MTSS) is a model that can be implemented in school buildings with the support of school district leaders. However, the voices of district leaders involved in MTSS implementation are limited in the research. This study sought to investigate what district leaders perceived as impacting factors towards MTSS implementation and draw conclusions about impacting factors from their opinions. Ten district leaders in a mountain west state of the United States were interviewed via Zoom and had their transcripts analyzed for impacting factors using a form of thematic analysis. All participants were involved with MTSS at their district …

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Full Issue Jun 2022

Full Issue

Journal of Response to Writing

No abstract provided.

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Preparing Students To Engage With Teacher Feedback, Grant Eckstein Jun 2022

Preparing Students To Engage With Teacher Feedback, Grant Eckstein

Journal of Response to Writing

No abstract provided.

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Using The “Card” Response Technique To Assist Middle School Students In The Revision Process, Katherine E. Batchelor Jun 2022

Using The “Card” Response Technique To Assist Middle School Students In The Revision Process, Katherine E. Batchelor

Journal of Response to Writing

Although revision is essential to the writing process, it is often neglected in schools. However, when revision is taught successfully, through reflection, conferencing, positive teacher feedback, specific instruction linked to reading strategies, and time between drafts in order for students to think about their writing (including the expectation of multiple drafts), students not only revise more, but at a deeper level. This study investigates how middle school students’ writing drafts as well as attitudes and beliefs toward revision changed based on introducing a specific revision strategy called the CARD response technique, which is both a self-response and peer-response strategy. CARD …

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Improving First- And Second-Year Student Writing Using A Metacognitive And Integrated Assessment Approach, Leanne Havis Jun 2022

Improving First- And Second-Year Student Writing Using A Metacognitive And Integrated Assessment Approach, Leanne Havis

Journal of Response to Writing

Metacognition emphasizes an awareness and understanding of one’s thought and cognitive processes, along with management of cognition through multiple strategies including organizing, monitoring, and adapting. Before students can truly become effective writers, they must develop an appreciation for the amount of planning, organization, and revision that comprises a writing assignment. In order to improve student writing, the exam autopsy approach, an integrated post-exam assessment model that draws upon self-assessment, peer review, and instructor feedback, was modified to include metacognitive components for use with essay exams and writing assignments. The current study employed a mixed-methods design with a quasi-experimental, non-equivalent group …

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Understanding Microstructure Heterogeneity In Li-Ion Battery Electrodes Through Localized Measurement Of Ionic Transport, Baichuan Liu Jun 2022

Understanding Microstructure Heterogeneity In Li-Ion Battery Electrodes Through Localized Measurement Of Ionic Transport, Baichuan Liu

Theses and Dissertations

Electrode microstructure influences ionic transport and electronic transport and is a key factor that affects lithium-ion battery performance. Non-uniform microstructure or heterogeneity in battery electrodes has long been observed and leads to non-uniform transport properties. This work provides a better understanding of in-plane heterogeneity at millimeter length scale and through-plane heterogeneity at micrometer length scale, through a combination of experiment and modeling. The first part of this work develops the aperture probe technique, which is an experimental method and associated model to locally estimate ionic transport, represented by MacMullin number, in the electrode. By generating contour maps of MacMullin number, …

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Material Development Toward An Index-Matched Gadolinium-Based Heterogenous Capture-Gated Neutron Detector, Aaron J. Thorum Jun 2022

Material Development Toward An Index-Matched Gadolinium-Based Heterogenous Capture-Gated Neutron Detector, Aaron J. Thorum

Theses and Dissertations

Neutron detection is important in several fields, especially detection of illicit nuclear material. Historically, 3He has been the basis for these technologies. Modern realities have necessitated the development of new technologies and the exploration of new materials to meet this need. One potential solution is known as capture-gating, which is a measurement approach that is good at differentiating between incident neutrons and gamma rays. The key issue is that materials used in current capture-gating devices can suffer from poor optical performance. This is due to the fact that the these detectors, whether composed of a heterogeneous or homogeneous mixture of …

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Dropout In Couple Therapy: An Exploration Of The Trajectories Of Couples Dropping Out, Ragan A. Lybbert Jun 2022

Dropout In Couple Therapy: An Exploration Of The Trajectories Of Couples Dropping Out, Ragan A. Lybbert

Theses and Dissertations

Dropout is a problematic phenomenon which wastes community, clinician, client, and researcher resources. Clients who dropout from therapy end up the same, or worse than, those who did not seek out therapy at all. While there is a relatively deep and broad understanding of dropout from individual therapy, an exhaustive review of couple therapy dropout literature reveals a very inconsistent and non-conclusive body of research. This may stem from a lack of a consistently used theory to guide research endeavors in this important realm. Primarily, this seems to stem from treating dropout as a static event rather than a process …

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Ducks In The Pond: Elementary-School-Age Children's Perceptions Of Standard American English, African American English, And Spanish-Accented English On Scales Of Status And Solidarity, Heather Jill Johnson Jun 2022

Ducks In The Pond: Elementary-School-Age Children's Perceptions Of Standard American English, African American English, And Spanish-Accented English On Scales Of Status And Solidarity, Heather Jill Johnson

Theses and Dissertations

The literature surrounding children's language attitudes has blossomed in recent years, but little is known about modern children's attitudes toward ethnic varieties of English. In addition, little is known about what factors may influence these attitudes. Here I investigate the language attitudes of children in kindergarten through third grade. These children in South Central Idaho have considerable experience with Spanish-accented English (SPE), but very little real-world experience with African American English (AAE). White, Latinx, and biracial participants were asked to evaluate samples of Standard American English (SAE), AAE, and SPE in relation to each other on scales of both status …

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Relationships Among Aa-Genome Chenopodium Diploids And A Whole-Genome Assembly Of The North American Species, C. Watsonii, Lauren Amillicent Young Jun 2022

Relationships Among Aa-Genome Chenopodium Diploids And A Whole-Genome Assembly Of The North American Species, C. Watsonii, Lauren Amillicent Young

Theses and Dissertations

Chenopodium quinoa Willd., an ancient Andean pseudocereal almost exclusively consumed in South America, jumped onto the global stage when Western cultures noted quinoa's advantageous nutritional profile. Quinoa seed's high protein content, nutritionally balanced amino acid profile, low glycemic index, and high fiber, vitamin, and mineral content, make it a highly sought-after 'superfood'. Pitseed goosefoot (C. berlandieri Moq.), a closely related North American species sharing quinoa's genome composition (AABB), grows across the North American continent, inhabiting diverse environments including the saline coastal soils of the Gulf of Texas and the drought-prone regions of the Southwest. Quinoa and pitseed goosefoot, along with …

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Improvement Of Ex Vivo Testing Methods For Spine Biomechanical Characterization, Aubrie Lisa Taylor Jun 2022

Improvement Of Ex Vivo Testing Methods For Spine Biomechanical Characterization, Aubrie Lisa Taylor

Theses and Dissertations

This dissertation contributed three main areas to flexibility testing and biomechanical characterization of human spinal segments. The first was a literature review of existing testing methodology, the second examined common spine fixation procedures, and the third developed an improved fixation method. Spine biomechanical characterization is the primary technique for assessing the healthy, diseased, and surgically treated response of spinal tissues. However, despite decades of use, no standard testing protocol or reporting methodology for flexibility testing conditions has been established. As part of the present work, a comprehensive, systematic literature review was performed, and the methods sections of 242 relevant journal …

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The Default Network And Autism Spectrum Disorder: Characterizing Sub-Networks And Behavioral Correlates, Alyssa K. Kozlowski Jun 2022

The Default Network And Autism Spectrum Disorder: Characterizing Sub-Networks And Behavioral Correlates, Alyssa K. Kozlowski

Theses and Dissertations

The default network (DN), and specifically its sub-networks default network A (DN A) and default network B (DN B), has been strongly implicated in social cognition. This study examined its role in predicting social behavior, and also differences that may exist across diagnostic groups that may explain discrepancies in social cognition and behavior. One of the popular methods of study is functional connectivity, or analyzing correlated activity in the brain. Autism Spectrum Disorder (ASD) is a disorder characterized by social impairment and abnormal social behavior. To date, much of the functional connectivity research in ASD has focused on global connectivity, …

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Analysis Of A Full-Stack Data Analytics Solution Delivering Predictive Maintenance To A Lab-Scale Factory, Nathan Wesley Hoyt Jun 2022

Analysis Of A Full-Stack Data Analytics Solution Delivering Predictive Maintenance To A Lab-Scale Factory, Nathan Wesley Hoyt

Theses and Dissertations

With the developments of industry 4.0, data analytics solutions and their applications have become more prevalent in the manufacturing industry. Currently, the typical software architecture supporting these solutions is modular, using separate software for data collection, storage, analytics, and visualization. The integration and maintenance of such a solution requires the expertise of an information technology team, making implementation more challenging for small manufacturing enterprises. To allow small manufacturing enterprises to more easily obtain the benefits of industry 4.0 data analytics, a full-stack data analytics framework is presented and its performance evaluated as applied in the common industrial analytics scenario of …

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Computational Methods To Simulate Molten Salt Thermophysical Properties, Talmage Porter, Michael M. Vaka, Parker Steenblik, Dennis Della Corte Jun 2022

Computational Methods To Simulate Molten Salt Thermophysical Properties, Talmage Porter, Michael M. Vaka, Parker Steenblik, Dennis Della Corte

Faculty Publications

Molten salts are important thermal conductors used in molten salt reactors and solar applications. To use molten salts safely, accurate knowledge of their thermophysical properties is necessary. However, it is experimentally challenging to measure these properties and a comprehensive evaluation of the full chemical space is unfeasible. Computational methods provide an alternative route to access these properties. Here, we summarize the developments in methods over the last 70 years and cluster them into three relevant eras. We review the main advances and limitations of each era and conclude with an optimistic perspective for the next decade, which will likely be …

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Midfoot Motion And Stiffness: Does Structure Predict Function?, Kirk Evans Bassett Jun 2022

Midfoot Motion And Stiffness: Does Structure Predict Function?, Kirk Evans Bassett

Theses and Dissertations

In clinical settings, dynamic foot function is commonly inferred from static and passive foot measurements; however, there is little evidence that static foot structure can predict dynamic foot function during walking gait. Previous research seeking to find correlations between the two have focused primarily on sagittal plane midfoot angles even though the midfoot has triplanar motion, which misses potentially important information. Additionally, the focus on kinematics alone may miss the contributions that forces play in midfoot mechanics. To address the angle limitations, a novel Signed Helical Angle (SHA) was developed to capture the triplanar motion of the midfoot from a …

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A Direct-Read, A Posteriori Golden Copy Method For Measuring Soc Cache Upsets, Evan D. Poff Jun 2022

A Direct-Read, A Posteriori Golden Copy Method For Measuring Soc Cache Upsets, Evan D. Poff

Theses and Dissertations

A method for measuring system-on-a-chip (SoC) cache upsets is presented and evaluated. In contrast to methods that predict cache contents through analysis or memory access patterns, this method uses system registers to read cache memories directly, thereby creating and checking golden copies to detect individual memory upsets during operation. The test method is driven by the device under test itself and does not require a user to set or know a priori the cache contents. A bare-metal implementation of this “direct golden method” on a Zynq UltraScale+ MPSoC logged upsets in the device’s data cache, data tag, and TLB RAM …

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The Apache Wars And The Swiss Sergeant, John Spring, Albert Winkler Jun 2022

The Apache Wars And The Swiss Sergeant, John Spring, Albert Winkler

Swiss American Historical Society Review

The Apache Wars were a series of conflicts that comprised the longest sequence of confrontations between a Native American Nation and the white Americans of the United States. These largely took place starting with the first US military incursions into the American Southwest in 1846 during the War with Mexico and lasted until Geronimo’s final surrender in 1886. While most of the fighting occurred in the modern US states of Arizona and New Mexico, yet much of the warfare was between the Mexicans and the Apaches dating back to the seventeenth century. Those wars were very costly in lives and …

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Full Issue, Albert Winkler, Robert Sherwood Jun 2022

Full Issue, Albert Winkler, Robert Sherwood

Swiss American Historical Society Review

Full Issue of Volume 58 issue 2 of the Swiss American Historical Society Journal

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Trauma And Poetry. The Case Of Primo Levi, Ilona Klein Jun 2022

Trauma And Poetry. The Case Of Primo Levi, Ilona Klein

Faculty Publications

Most North American readers have come to know and appreciate Primo Levi by his major works in prose. His The Periodic Table (1984) catapulted Levi onto the American stage of scientific-humanistic authors, having the New York Times named it among the Best Books of the Year in 1985. Instead, American readers will likely stumble upon Levi’s poetry by accident, simply because every now and then one of his poems in translation appears in print somewhere. Compared to Levi’s prose, his poems inevitably evoke a sense of unease, for their tone, their style and their content are so unlike the familiar, …

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Treatment Pearls: Management Of Physical Healthcare Needs In Patients With Mental Illness, Leslie W. Miles, Brandon Thatcher, Michael C. Thomas, Blaine Winters Jun 2022

Treatment Pearls: Management Of Physical Healthcare Needs In Patients With Mental Illness, Leslie W. Miles, Brandon Thatcher, Michael C. Thomas, Blaine Winters

Faculty Publications

Clinicians caring for persons with mental illness should be aware of increased mortality, physical problems, and health disparities in this population. This article provides a brief overview of physical health problems in the context of mental illness as well as those related to psychotropic medications, and discusses strategies to manage treatment effectively.

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In Their Own Words: Perspectives On Collection Weeding From Library Employees And Teaching Faculty, Dan Broadbent, Megan Frost, Gregory M. Nelson, David Pixton Jun 2022

In Their Own Words: Perspectives On Collection Weeding From Library Employees And Teaching Faculty, Dan Broadbent, Megan Frost, Gregory M. Nelson, David Pixton

Faculty Publications

Following a Science and Engineering collection weeding project of over 350,000 print items, our research team conducted interviews with 20 library employees and 19 teaching faculty involved in the project. The purpose of the interviews was to assess the interviewees’ perspectives and feelings relating to the time required to complete the project, inter- and intra- library communication, the decision-making processes, and their personal assessment of the costs and benefits of the project. The interviewees also offered their views of the overall project’s successes and areas for improvement. Drawing from a qualitative analysis of the interviews, we provide guidance for other …

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Flowunsteady: An Interactional Aerodynamics Solver For Multirotor Aircraft And Wind Energy, Eduardo Alvarez, Judd Mehr, Andrew Ning Jun 2022

Flowunsteady: An Interactional Aerodynamics Solver For Multirotor Aircraft And Wind Energy, Eduardo Alvarez, Judd Mehr, Andrew Ning

Faculty Publications

The ability to accurately and rapidly assess unsteady interactional aerodynamics is a shortcoming and bottleneck in the design of various next-generation aerospace systems: from electric vertical takeoff and landing (eVTOL) aircraft to airborne wind energy (AWE) and wind farms. In this study, we present a meshless CFD framework based on the reformulated vortex particle method (rVPM) for the analysis of complex interactional aerodynamics. The rVPM is a large eddy simulation (LES) solving the Navier-Stokes equations in their vorticity form. It uses a meshless Lagrangian scheme, which not only avoids the hurdles of mesh generation, but it also conserves the vortical …

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