Digital Commons Network^™

Acoustothermal Transfection For Cell Therapy, Xiufang Liu, Ning Rong, Zhenhua Tian, Joseph Rich, Lili Niu, Pengqi Li, Laixin Huang, Yandai Dong, Wei Zhou, Pengfei Zhang, Yizhao Chen, Congzhi Wang, Long Meng, Tony Jun Huang, Hairong Zheng

Faculty Publications

Transfected stem cells and T cells are promising in personalized cell therapy and immunotherapy against various diseases. However, existing transfection techniques face a fundamental trade-off between transfection efficiency and cell viability; achieving both simultaneously remains a substantial challenge. This study presents an acoustothermal transfection method that leverages acoustic and thermal effects on cells to enhance the permeability of both the cell membrane and nuclear envelope to achieve safe, efficient, and high-throughput transfection of primary T cells and stem cells. With this method, two types of plasmids were simultaneously delivered into the nuclei of mesenchymal stem cells (MSCs) with efficiencies of …

Hózhó + Art Heals, Eugene Tapahe

Theses and Dissertations

The land where I grew up gives me a sense of purpose and belonging. It embodies the Navajo concept of hózhó, which represents harmony, beauty, and balance. Being in tune with this spiritual connection inspires me to bring people together through art and healing. I use natural materials like sand, sage, cedar, tree twigs, and yellow and blue cornmeal to create my art. To maintain the spirituality of my work, I employ traditional and ritualistic harvesting methods passed down from generation to generation. These techniques are deeply connected to the land and are essential to my identity as an artist …

Developing An Artistic Self In Preservice Elementary Teachers: A Studio Art Curriculum To Promote Art Integration, Karilee D. Park

Theses and Dissertations

With the continual use of standardized testing, teaching art in schools, particularly elementary schools, often falls to generalist teachers with little to no experience in art. While art can be integrated into daily curriculum for deeper and lasting learning, without the proper training or support, generalist teachers are left to implement art as they encountered it in the past, if at all. Artistic anxiety and culturally misappropriated artistic experiences result in the arts being used inefficiently or avoided completely. Creating a curriculum for preservice elementary generalist teachers, I explored art integration through developing artistic confidence, skill, and identity for 16 …

Death Stranding: A New Digital Ecology, Jordan Long

Theses and Dissertations

This essay analyzes Death Stranding, the 2019 release from contemporary game auteur Hideo Kojima. Here, I discuss the unique potentialities of this game world, detailing the ways in which Death Stranding expresses ecological perspectives. Asynchronous multiplayer serves as a unique metagame, helping to prove that play is a process of action which facilitates ecological thinking. The world of Death Stranding is filled with strange objects. The nonhuman entities that the player encounters throughout the game, for example, seem entirely alien. And yet, when these entities are properly understood, we realize that their inclusion is necessary--and natural. Your "job" in the …

Still Life Happens, Mary Ann Crabtree

Theses and Dissertations

After dedicating over two years to pursuing an MFA degree focused on ceramics and sculpture, I find myself transported back to a familiar setting from my past: a tableau reminiscent of what remained in the dining space after four young children finished a meal and exited the room. Revisiting the scene recalls happy times despite the disorder. What helped maintain my sanity during the relentless repetition of the every-day-long task was the realization that every day, innocents are learning to become aware of the world around them. For my thesis exhibition, I created a tableau as a loud reminder of …

Comics About Organs: Social Support And Graphic Medicine In The Awkward Yeti, Jacob Gibb

Theses and Dissertations

Comic strips have always been a medium for more than humor. Many comic strips published on social media sites address mental health issues. Despite their popularity, the field of graphic medicine, which examines the intersection of health care and comics, has seen little to no examination of how these comics function on social media. Utilizing the popular comic The Awkward Yeti, this research examines how the rhetorical devices of comics make them an ideal medium for communicating about mental health issues and providing social support to social media users. This study conducts a content analysis of 15 Instagram posts from …

"Great Injustice In American Literature": African American Girlhood In Black And White Authored Children's Publications, 1887-1920, Becca Driggs

Undergraduate Honors Theses

This thesis examines the role of African American girls in creating and dismantling nineteenth-century race myths through a comparison of publications in black and white authored presses. Fictional stories published in St. Nicholas, the most popular turn-of-the-century children’s magazine, reveal that white authors, specifically Southern women, intentionally crafted narratives demeaning African American girls to cement a national racial hierarchy. Their work indoctrinated white children in racism and undermined African American legitimacy in the decades following the Civil War and Reconstruction. Concurrently, black authors recognized these attacks and in their press explored the lived experiences of African American girls to counter …

Quantifying And Characterizing The Behavior Of Dissolved And Suspended Icp-Oes Detectible Elements In Utah Lake, Rachel Ann Valek

Theses and Dissertations

For Utah Lake in Utah, USA, we analyzed a uniquely comprehensive and longitudinal water quality dataset that extended over two summer sampling seasons. We measured 61 parameters using Inductively Coupled Plasma Optical Emission Spectrometry (ICP-OES), YSI ProDSS water sondes, and laboratory procedures to quantify and characterize dissolved and suspended behavior of trace elements in Utah Lake. We analyzed the data using principal component analysis (PCA) and multidimensional scaling (MDS) to understand the lake geochemistry and inform Utah Lake management decisions regarding nutrients and algal blooms. We found that 1) sediments rich in phosphorus (P) act as a source for bioavailable …

"Moloch Of The Present Mode": Women's Short Hairstyles In Nineteenth-Century American Society, Jack Tingey

The Thetean: A Student Journal for Scholarly Historical Writing

An article from Indianapolis journal in 1883 reported on the phenomenon of women cutting their hair short in the name of fashion, describing the process of a woman cutting off her long hair as akin to sacrificing virtue to the "Moloch of the present mode." Today, short hairstyles are more commonly associated with the bob of the Roaring Twenties, an era historians and popular culture recognize as one of excess, social change, and new innovations. But short hair on women was by no ~ans new in the 1920s. The bob was not the first short hairstyle in the United States …

Maya-Catholic Theologian: The Influence Of Maya Theology On Catholic Doctrine In The Morley Manuscript, Travis Meyer

The Thetean: A Student Journal for Scholarly Historical Writing

In 1576, at the height of Catholic evangelization in the Yucatan Peninsula in Mexico, an unnamed Catholic preacher met regularly with a congregation of indigenous Maya to teach them the doctrine of Christianity. He taught them about the biblical creation, as well as the nature of God and the devil, all from his own original doctrinal instructional manual. This preacher was also a Maya himself Between the years 1500 and 1800, only about 1,100 European-descended Catholic friars ministered to the tens of millions of Maya in Mesoamerica. Because there were so many natives and so few friars, they could not …

Project-Based Learning: An Online Support Product For Scaffolding The Professional Development In China, Yenny Mo

Instructional Psychology and Technology Graduate Student Projects

This project was a collaboration between Brigham Young University (BYU) in Provo, Utah, U.S.A., and Beijing Normal University (BNU) in Beijing, China. It aimed to enhance the effectiveness of the existing professional development (PD) program at BNU by developing an online support product. The PD program focuses on developing project-based learning (PjBL) cases and its implementation in a classroom.

This online support product that scaffolds the PD program using Articulate Storyline 360. Through a strategic integration of the ADDIE and RP models, I have created a tool that facilitates faster comprehension of PjBL concepts, enables effective design of driving questions, …

The Effects Of Racial Prejudice And Humanization On Private Aid Donations, Mary Harris, Ashlynn Hokanson, Zeke Peters, Phoebe Roberts, Daniel Nielson

Sigma: Journal of Political and International Studies

World Vision predicts that there are more than 719 million people living in poverty (Peer 2023). Charitable organizations often strive to fill gaps of government programs and alleviate poverty by offering food, clothing, and support to these millions of individuals in need. To be successful in realizing the goals of these charitable organizations, the quantity of charitable donations must be large to create change. Charitable organizations regularly attempt to obtain donations through means of advertising; however, are these methods of advertising effective in soliciting donations to help underprivileged populations across the globe? By improving the understanding of effective donation solicitation …

Full Issue

Brigham Young University Prelaw Review

No abstract provided.

Safeguarding Wetlands Post-Sackett V. Epa: Protecting Indigenous Territories And Environmental Health, Anna J. Mahler, Emily Richardson

Brigham Young University Prelaw Review

The Clean Water Act (CWA) has been a tool for federally recognized tribes to protect the waters within their borders and sacred lands that exist outside the borders of the tribe. Sackett v. EPA limited the scope of the CWA to cover only wetlands that have a continuous surface connection. This restricts the ability of Tribes to protect important waters. The Sackett decision decreases the nation’s ability to protect the chemical, physical, and biological aspects of the waters. This paper explores past legislative remedies and proposes federal wetland protection.

Plagiarism Or Progress?: An Inquiry Into Generative Ai And Copyright, James Knight

Brigham Young University Prelaw Review

The emergence of accessible artificial intelligence (AI) in 2022, including notable models such as Chat GPT, Google Bard, and Microsoft Bing Chat, has sparked significant discourse regarding their societal impact. This paper delves into the contrasting perspectives regarding the role of Large Language Models (LLMs) in society, particularly in the realm of copyright law. While pessimists express concerns about the potential stifling of human ingenuity and innovation, optimists advocate for embracing AI's creative potential, advocating for legal reforms to address copyright issues. Focusing on the legal domain, this paper argues for amending US copyright law to accommodate AI-generated content, proposing …

Drug Modification Of Synaptic Plasticity At The Inhibitory Synapses Involving Gaba Neurons In The Ventral Tegmental Area, Jie Wu

Theses and Dissertations

The neurobiological underpinnings of substance use disorders (SUDs) involve complex alterations in synaptic plasticity within the mesolimbic dopamine system, particularly within the ventral tegmental area (VTA). While dopamine neurons in the VTA are extensively studied in addiction research, less attention has been given to the plasticity exhibited by VTA GABAergic neurons, despite their established regulatory role in modulating dopamine cell activity. Building upon the ground-breaking work of Bocklisch et al. (2013), we investigated the plasticity at the GABAergic to VTA GABA neuron (VTA GABA-to-GABA) synapse utilizing whole-cell electrophysiology in GAD67 GFP knock-in mice. Our findings revealed an exceptionally rare duo-plasticity …

Prosodic Speech Rate, Utterance Duration, Interruption Rate, And Turn-Taking Latency In Autistic And Neurotypical Adults, Grace Madeline Bell

Theses and Dissertations

The purpose of this study was to examine the following prosodic elements: speech rate, turn-taking latency, number of interruptions, and utterance duration across two groups' neurotypical and autistic young adults. Furthermore, the end goal of this study is to help provide a baseline and clinical application of prosodic differences between autistic and neurotypical adults. Speech samples were collected from 11 neurotypical and 11 autistic young adults from the ages of 18-26. Speech samples were recorded responses from a 10-minute interview between two research assistants and the autistic or neurotypical individual. Using Praat software, speech samples were analyzed and used to …

Slim Winnings For Tubby Taft: Utah And The Presidential Election Of 1912, Natalie Larsen

The Thetean: A Student Journal for Scholarly Historical Writing

Traveling on a special passenger train from Salt Lake City to Los Angeles, Utah governor William Spry waxed uncharacteristically eloquent with the reporters who hounded him for his insights on the 1914 congressional elections. Sent by the roundly Republican newspaper the Los Angeles Times, the reporters were looking to see how the dust had settled after the humiliating Republican losses two years earlier in 1912. Democrat Woodrow Wilson won a resounding victory that year, while Theodore Roosevelc's Progressive Parry won eighry-eight electoral votes, and the incumbent president William Howard Taft limped away with a meager eight electoral votes. Considering …

The Effect Of The Destruction Of The Jerusalem Temple On The Jewish Perception Of The Sacrificial Cult: A Look At Pseudepigraphical, Deuterocanonical, And Rabbinic Texts, Allen Kendall

The Thetean: A Student Journal for Scholarly Historical Writing

Though many of us are somewhat familiar with today's modern world religions and with ancient religion inasmuch as it is portrayed in our own religious literature, we often do not understand how we got from the ancient world to the modern. For the most part we understand how ancient Jews worshipped in Jerusalem according to the Law of Moses and chat certain biblical practices have changed, but we are not aware of how this happened. This paper attempts to bridge that gap of knowledge by tracing the development of Jewish religious thought and practice vis-a-vis the sacrificial cult. Over the …

Rebirth And Renewal In Maya Ritual From The Precolonial Period To The Present, Madeline Duffy

The Thetean: A Student Journal for Scholarly Historical Writing

The concepts of rebirth and renewal were paramount in pre-Columbian Maya culture. Traditionally, the Maya believe chat everything passes through a never-ending cycle of birch, maturation, decay, death, and rebirth. This cycle encompasses the elements of everyday life which the Maya could perceive: the human life cycle, the life cycle of crops, the seasons, and even the rise and fall of the sun. They noticed chat all of these day-today happenings "have their beginnings in a creative ace and ultimately weaken and die in an orderly succession of days chat is both comforting in its predictability and terrifying in its …

In Search Of Super-Scents For Carnivore Attraction, Megan Doxey

Library/Life Sciences Undergraduate Poster Competition 2024

Find chemical scents that are more effective at alluring North American predators than what is commercially available, then isolate the scent’s chemical structure to create better trapping lures.

Using Arbuscular Mycorrhizal Fungi To Help Establish And Increase Vigor Of Plants In Mineland Soils, Melissa Burrell, Brad Geary, Shannon Nelson, Josh Moroni De Santiago Lazalde, Scott Kent, Matthew Madsen

Library/Life Sciences Undergraduate Poster Competition 2024

• Vegetation establishment in areas impacted by mining can be difficult due to a lack of beneficial soil microbes.
• The introduction of soil mutualists, such as arbuscular mycorrhizal fungi (AMF), may improve mineland revegetation efforts. AMF forms a mutually beneficial relationship with plants to aid in nutrient absorption and improve water uptake.
• Practitioners commonly need to decide where to source their AMF. Locally collected AMF requires effort to collect and process, but this source should be adapted to the restoration site. Commercial products are easy to obtain, but their strains may not be suitable for the environment they are being placed …

Valproic Acid Alters Larval Behavior And Neuronal Composition Within The Optic Tectum Of Zebrafish, Bailey J. Calder, Jacquelyne C. Howell, Michael J. Zeyer, Annalie Martin, Sierra C. Dixon, Shane M. Lilya, Jason M. Hansen, Arminda Suli

Library/Life Sciences Undergraduate Poster Competition 2024

The mammalian superior colliculus (SC) and its non-mammalian homolog–the optic tectum (OT)–are midbrain structures that integrate multimodal sensory inputs and guide involuntary movements in response to relevant environmental cues. Recent work has drawn strong connections between the functions of the SC/OT and behavioral deficits observed in autism spectrum disorder (ASD), thus implicating this structure as a possible site affected in ASD. Since fetal exposure to valproic acid (VPA) has been associated with increased prevalence of ASD in humans, and ASD-like phenotypes in animal models, we exposed embryonic zebrafish to VPA to investigate the connection between ASD and OT development. In …

Advancing Mycotoxin Detection: Multivariate Rapid Analysis On Corn Using Surface Enhanced Raman Spectroscopy (Sers), Allison Gabbitas, Gene Ahlborn, Kaitlyn Allen, Shintaro Pang

Library/Life Sciences Undergraduate Poster Competition 2024

Background and Purpose: Mycotoxin contamination on food and feed can have deleterious effect on human and animal health. Agricultural crops may contain one or more mycotoxin compounds; therefore, a good multiplex detection method is desirable to ensure food safety. In this study, we developed a rapid method using label-free surface-enhanced Raman spectroscopy (SERS) to simultaneously detect three common types of mycotoxins found on corn, namely aflatoxin B1 (AFB1), zearalenone (ZEN), and ochratoxin A (OTA).

Methods: A SERS nanosubstrate was applied on the agricultural crop (i.e., corn) and mixed briefly with mycotoxins present on the surface. Raman spectral data …

Exploring Changes In Micro-Invertebrate Species Composition In Rock Pools Of The Colorado Plateau, Hamer Goolsby, Russell Rader, Sara Schenk

Library/Life Sciences Undergraduate Poster Competition 2024

• In ecology, desert rock pools form an ideal model ecosystem. These typically isolated pools a small enough that a researcher can observe the entire system and record everything going into and out of this aquatic system. This removes one of the most important confounding factors for observational studies in ecology, making rock pools an important system to understand.
• The rock pools of the Colorado Plateau in the western United States consist of three main types: 1) scoured pools in temporary stream channels that violently flood during rainstorms (locally called Tinajas), 2) shorthydroperiod pools which are shallow depressions (< 0.6 m deep) that thaw in March and dry by the end of April , and 3) long hydroperiod pools which are deep pools (1-3 m) that thaw in March and persist until June.
• Meiofauna (animals …

Effects Of Predation On Cognition In Brachyrhaphis Rhabdophora, Elizabeth F. Jenkins, Jerry B. Johnson

Library/Life Sciences Undergraduate Poster Competition 2024

RESEARCH QUESTION

Does “predation environment” affect the cognitive abilities of the tropical fish Brachyrhaphis rhabdophora?

Variation In Vital Rates Among Least Chub (Iotichthy Phlegethontis), Lauren Applebee, Mark C. Belk, Nathan St. Andre

Library/Life Sciences Undergraduate Poster Competition 2024

Conservation plans for a species often requires knowledge of population trends. These trends can be difficult to acquire, but one piece of information that can be attained from populations is the catch per unit effort (CPUE). We are trying to use CPUE in a new way to determine population demography for populations of Iotichthys phlegethontis, Least Chub.

Bird And Small Mammal Preference For Water Developments, Lizzie Wilson, Randy Larsen

Library/Life Sciences Undergraduate Poster Competition 2024

 Different types of water developments nicknamed “guzzlers” have been installed in many different arid and semi-arid environments to provide water resources to game species in the state of Utah.

 Upland game guzzlers are usually covered by a sheet of metal and are used to target species like chukar partridge and quail (Figure 1).

 Big game guzzlers are open pools of water that are used to target species like mule deer and desert big horn sheep (Figure 2).  Most visitations to guzzlers are by native species not targeted by the guzzlers or wildlife management efforts (3).

Exploring Extended Reality In An Aqueous Processing Test Bed For Nuclear Material, Sam Wald

Undergraduate Honors Theses

This research aided in the ongoing creation of an extended reality training experience for Beartooth, an aqueous processing test bed for nuclear material, by exploring what will be comfortable and effective for users of the experience. Participants consisted of staff members from Idaho National Laboratory (INL) and authorized members of the Augmented Learning Lab at BYU. We conducted usability testing with participants who were given extended reality (XR) equipment to explore the Beartooth virtual training system. We also performed a heuristic evaluation on the system using an augmented reality evaluation checklist. Findings were discussed with the INL team and recommendations …

Framing An Adversary: Ethnic Nationalism In The First Khmer Newspaper, Ian Lowman

The Thetean: A Student Journal for Scholarly Historical Writing

The study of nationalism examines both global patterns and the singleness of local response. In most fledgling nation-states, the modern phenomena of print and western capitalism transformed indifferent individuals into a politicized public. Printing houses profitably publicized and glorified vernaculars while propagating European ideas of state borders, national cultures, and patriotism. By employing this medium, nationalists toyed with ideologies specific to the concerns of their community; French nationalism thrived on an abstract battle against tyranny while Algerians couched their nationality in the struggle for freedom from France. Each nation's self-conception reflected a search for an ideal of commonality and a …