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Climate Change Impacts And Implications: An Integrated Assessment In A Lowland Environment Of New Zealand, A. G.E. Ausseil, K. Bodmin, A. Daigneault, E. Teixeira, E. D. Keller, M. U. F. Kirschbaum, L. Timar, A. Dunningham, C. Zammit, S. Stephens, M. Cameron, P. Blackett, G. Harmsworth, B. Frame, A. Reisinger, A. Tait, D. Rutledge Jul 2016

Climate Change Impacts And Implications: An Integrated Assessment In A Lowland Environment Of New Zealand, A. G.E. Ausseil, K. Bodmin, A. Daigneault, E. Teixeira, E. D. Keller, M. U. F. Kirschbaum, L. Timar, A. Dunningham, C. Zammit, S. Stephens, M. Cameron, P. Blackett, G. Harmsworth, B. Frame, A. Reisinger, A. Tait, D. Rutledge

International Congress on Environmental Modelling and Software

New Zealand’s mixed economy includes a range of sectors (e.g. primary production, energy, tourism) that depend heavily on the state of natural resource capital. This makes the economy heavily dependent on future global climate change and the global economic situation. In this paper, we present a framework to evaluate socio-economic and environmental impacts of future climate and land-use change, and give results for one scenario in a typical lowland environment in New Zealand. The future scenario was designed as a combination of global climate and socio-economic assumptions, along with New Zealand-specific policy assumptions. We evaluated the impacts and implications of …


An Agent-Based Model For Studying The Effects Of Sustainable Intensification On Food Security In The Nation State, James Reilly, Terry Dawson, Robin Matthews, Gary Polhill, Pete Smith Jul 2016

An Agent-Based Model For Studying The Effects Of Sustainable Intensification On Food Security In The Nation State, James Reilly, Terry Dawson, Robin Matthews, Gary Polhill, Pete Smith

International Congress on Environmental Modelling and Software

Growth in World’s population, the expansion of human activities and the demand for land has and continues to damage the natural environment. Humans depend on the natural environment for essential life-preserving processes, for example food production. Damage to the environment has serious consequences for national (State) and human security and well-being. One concern is food security and, in particular, whether a growing World population will find enough food to eat. The consequences of using more land and resources to grow more food are an important area of research. The expansion of farming will leave less land for other important uses. …


Residual Soil Nitrogen Scenario Analysis Of Canadian Farmland Using A Canadian Agricultural Nitrogen Budget (Canb V4.0) Model, Jingyi Yang, Craig Drury Jul 2016

Residual Soil Nitrogen Scenario Analysis Of Canadian Farmland Using A Canadian Agricultural Nitrogen Budget (Canb V4.0) Model, Jingyi Yang, Craig Drury

International Congress on Environmental Modelling and Software

A Canadian Agricultural Nitrogen Budget (CANB) model has been developed since 2002 to estimate Residual Soil Nitrogen (RSN) and N leaching loss across Canadian farmland. The current results showed that national RSN averages in Canadian farmland (annual N input minus annual N output) increased from 9.4 kg N ha-1 in 1981 to 23.6 kg N ha-1 in 2011 as mainly affected by the increase in synthetic fertilizer N usage and biological N2 fixation. With annual drainage, about 50 and 80% of residual soil N was lost in Central (Ontario and Quebec) and Atlantic Canada, respectively, through leaching and varying according …


System Dynamics And Bayesian Network Models For Vulnerability And Adaptation Assessment Of A Coastal Water Supply And Demand System, Thuc D. Phan, Oz Sahin, James Cr. Smart Jul 2016

System Dynamics And Bayesian Network Models For Vulnerability And Adaptation Assessment Of A Coastal Water Supply And Demand System, Thuc D. Phan, Oz Sahin, James Cr. Smart

International Congress on Environmental Modelling and Software

A coastal water supply and demand system is a highly uncertain and dynamically complex system. The degree of high uncertainty can arise from future climate change, population growth, water consumption trends, land use changes and socio-economic development, resulting in limited availability of empirical data. The effects of temporal and spatial interactions among such driving factors further contribute to the high dynamic complexity of coastal freshwater management. To effectively manage a coastal freshwater system with high levels of uncertainty and complexity, a participatory integrated System dynamics (SD) and Bayesian networks (BNs) modelling framework was suggested to assess the vulnerability and adaptation …


Implementing Urine Patches In A Dynamic Process- Based Simulation Model, V. O. Snow, R. Cichota, N. J. Hutchings, J. Vejlin Jul 2016

Implementing Urine Patches In A Dynamic Process- Based Simulation Model, V. O. Snow, R. Cichota, N. J. Hutchings, J. Vejlin

International Congress on Environmental Modelling and Software

Grazing ruminants harvest N from pasture in the entire paddock and then deposit between 40 and 80% of the ingested N into urine patches that cover only 2-4% of the paddock area during a typical rotational grazing event. While previous work has shown the importance of explicitly modelling these patches of very high N deposition, most process-based simulation models assume uniform return of N to the soil. The very few models that explicitly model urine patches within the paddock do so at significant, perhaps prohibitive, computational cost. We sought a solution that would preserve the most important biophysical effects but …


Scientific Research Documentation - An Information Server For The National Park Hunsrück-Hochwald, Peter Fischer-Stabel, Micheal Mattern Jul 2016

Scientific Research Documentation - An Information Server For The National Park Hunsrück-Hochwald, Peter Fischer-Stabel, Micheal Mattern

International Congress on Environmental Modelling and Software

Within the world network of nature reserves, a national park is a park in use for conservation purposes. Beside it´s high value for nature and biodiversity, national parks are serving as sites for research, environmental monitoring, education and training. In order to ensure a long-lasting, central and efficient access to the literature and data on such a nature reserve for all scientists from the respective institutions, a research information portal was established for the National Park Hunsrück-Hochwald. Based on a user requirements analysis, a client-server architecture using open source components was set up. Core modules are a metadata-management component and …


Supporting Wildlife Conservation By Modelling The Effectiveness Of Community-Led Poacher Mitigation, Marit E. Kragt, Eric J. Hay, Micheal Renton Jul 2016

Supporting Wildlife Conservation By Modelling The Effectiveness Of Community-Led Poacher Mitigation, Marit E. Kragt, Eric J. Hay, Micheal Renton

International Congress on Environmental Modelling and Software

Illegal hunting and poaching are severely threatening biodiversity in Southeast Asia, especially those species that are rare or threatened. Management strategies to address this poaching problem include wildlife patrols that collect and remove wire snares. While studies exist that predict the impact of poaching on biodiversity loss, there are few studies that evaluate the effectiveness of policy strategies. We present a model that predicts how community-led poaching mitigation patrols could help wildlife conservation the Lao People's Democratic Republic (PDR). The results show that, without intervention, nearly all species will be poached to local extinction over the next 10 years. We …


Livelihoods Of Local Communities In An Amazonian Floodplain Coping With Global Changes: From Role-Playing Games To Hybrid Simulations To Involve Local Stakeholders In Participatory Foresight Study At Territorial Level, Pierre Biommel, Marie-Paule Bonnet, Emilie Coudel, Eva Haentjens, Cleber Nunes Kraus, Gustavo Melo, Stephanie Nasuti, Christophe Le Page Jul 2016

Livelihoods Of Local Communities In An Amazonian Floodplain Coping With Global Changes: From Role-Playing Games To Hybrid Simulations To Involve Local Stakeholders In Participatory Foresight Study At Territorial Level, Pierre Biommel, Marie-Paule Bonnet, Emilie Coudel, Eva Haentjens, Cleber Nunes Kraus, Gustavo Melo, Stephanie Nasuti, Christophe Le Page

International Congress on Environmental Modelling and Software

In the Amazonian floodplains, the local populations living from agricultural activities and fishing, have always coped natural variations, between flood and dry seasons. However, the rhythm and the amplitude of these floods are disturbed nowadays, resulting in great uncertainty for these populations. Biophysics and social scientists have joined hands to help these populations better improve their resilience to such changes. Our initial goal aims to better understand and discuss the impacts of current practices in the long term. To address this, we first turned the perspective around the preoccupations and strategies of local populations and collectively discussed possible future scenarios. …


Explicit Cost Accounting For Adaptation, Mitigation And Ecosystem Service Provision In Agriculture, Franz Sinabell, Karin Heinschink, Christoph Tribl Jul 2016

Explicit Cost Accounting For Adaptation, Mitigation And Ecosystem Service Provision In Agriculture, Franz Sinabell, Karin Heinschink, Christoph Tribl

International Congress on Environmental Modelling and Software

Farmers, policy makers and scientists are well aware of this problem: obtaining sound cost information for climate change adaptation and mitigation measures in agriculture or ecosystem service provision by agriculture is burdensome. In most cases, data sets are developed for a specific region with a given set of management variants for a baseline period. Adapting such information to another region or adjusting costs to expected future price scenarios requires additional efforts and frequently done an ad-hoc and case by case. A new tool is presented that can be used to identify and analyze the entangled effects of future climate and …


A Workflow To Model Microbial Loadings In Watersheds, Kurt Wolfe, Rajbir Parmar, Gene Whelan, Gerard F. Laniak, Mike Galvin, Keewook Kim, Marirosa Molina, Richard Zepp, Paul Duda, Dennis D. Keiser Jul 2016

A Workflow To Model Microbial Loadings In Watersheds, Kurt Wolfe, Rajbir Parmar, Gene Whelan, Gerard F. Laniak, Mike Galvin, Keewook Kim, Marirosa Molina, Richard Zepp, Paul Duda, Dennis D. Keiser

International Congress on Environmental Modelling and Software

Many watershed models simulate overland and instream microbial fate and transport, but few actually provide loading rates on land surfaces and point sources to the water body network. This paper describes the underlying general equations for microbial loading rates associated with 1) land- applied manure on undeveloped areas from domestic animals; 2) direct shedding on undeveloped lands by domestic animals and wildlife; 3) urban or engineered areas; and 4) point sources that directly discharge to streams from septic systems and shedding by domestic animals. A microbial source module, which houses these formulations, is linked within a workflow containing eight models …


The Pasture Simulation Model – Evaluation Of Plant Acclimatory Effects On Grassland Systems In France, Serge Zaka, Renáta Sándor, Raphaël Martin, Gaëtan Louarn, Katja Klumpp, David Borras, Gianni Bellocchi Jul 2016

The Pasture Simulation Model – Evaluation Of Plant Acclimatory Effects On Grassland Systems In France, Serge Zaka, Renáta Sándor, Raphaël Martin, Gaëtan Louarn, Katja Klumpp, David Borras, Gianni Bellocchi

International Congress on Environmental Modelling and Software

The temperature responses of plant photosynthesis and respiration observed on single-plant species can be assumed to occur at the scale of a grassland ecosystem (which is a dynamic and competitive associations of plants). Based on the model for a single, fully expanded leaf as derived from experimental evidence and to gain insights into acclimatory and modulatory effects of growth temperature, we have: 1) improved a complex soil-vegetation-management model of grasslands, PaSim (Pasture Simulation model), and 2) evaluated it on multi-year datasets of plant biomass and C-water- energy fluxes in managed grassland systems. Illustrative results are presented for the French grassland …


Agent-Based Modelling: What Matters Is Action, Franҫois Guerrin, Zoubida Afoutni, Rémy Courdier Jul 2016

Agent-Based Modelling: What Matters Is Action, Franҫois Guerrin, Zoubida Afoutni, Rémy Courdier

International Congress on Environmental Modelling and Software

Computer-aided management tools or models of production systems in the manufacturing or agricultural domains generally rely implicitly on the theory of planned action. Every action is assumed to be part of an anticipated sequence leading from a current state to a predetermined goal. The main limits of this classical view are due to the difficulty to deal with unexpected changes and disturbances. To overcome these limits, we developed an agent model based on the theory of situated action. Whereas the classical approach puts the emphasis on actor’s decision (action being assumed to straightforwardly follow), situated action is viewed as a …


Documenting Models For Interoperability And Reusability, Rajbir Parmar, Kurt Wolfe, Gene Whelan, Gerard F. Laniak, Mike Galvin, Jonathan L. Goodall Jul 2016

Documenting Models For Interoperability And Reusability, Rajbir Parmar, Kurt Wolfe, Gene Whelan, Gerard F. Laniak, Mike Galvin, Jonathan L. Goodall

International Congress on Environmental Modelling and Software

Many modeling frameworks compartmentalize science via individual models that link sets of small components to create larger modeling workflows. Developing integrated watershed models increasingly requires coupling multidisciplinary, independent models, as well as collaboration between scientific communities, since component-based modeling can integrate models from different disciplines. Integrated Environmental Modeling (IEM) systems focus on transferring information between components by capturing a conceptual site model; establishing local metadata standards for input/output of models and databases; managing data flow between models and throughout the system; facilitating quality control of data exchanges (e.g., checking units, unit conversions, transfers between software languages); warning and error handling; …


Conceptualizing Blended Learning Engagement, Lisa R. Halverson Jul 2016

Conceptualizing Blended Learning Engagement, Lisa R. Halverson

Theses and Dissertations

Learner engagement, or the involvement of the student's cognitive and emotional energy to accomplish a learning task, has been called "the holy grail of learning" (Sinatra, Heddy, & Lombardi, 2015, p. 1) because of its correlations to academic achievement, persistence, and satisfaction. In the 21st century, learning will be increasingly "blended," combining face-to-face with computer-mediated instruction. Research is already exploring learner engagement in blended contexts, but no theoretical framework guides inquiry or practice. Developing models and measures of the factors that facilitate learner engagement is important to the advancement of the domain. This multiple-article format dissertation addresses the theoretical gap …


Integrators Of Design: Parsi Patronage Of Bombay's Architectural Ornament, Nicole Ashley Vance Jul 2016

Integrators Of Design: Parsi Patronage Of Bombay's Architectural Ornament, Nicole Ashley Vance

Theses and Dissertations

The seaport of Bombay is often referred to as India's "Gothic City." Reminders of British colonial rule are seen throughout South Bombay in its Victorian architecture and sculpture. In the heart of Bombay lies the Victoria Terminus, a towering, hybrid railway station blending gothic and vernacular architectures. Built at the height of the British Empire, the terminus is evidence of the rapid modernization of Bombay through the philanthropy of the Parsis. This religious and ethnic minority became quick allies to the British Raj; their generous donations funded the construction of the "Gothic City." The British viewed the Parsis as their …


Group Flow In The Byu Animation Studio, Jana Lynn Duncan Jul 2016

Group Flow In The Byu Animation Studio, Jana Lynn Duncan

Theses and Dissertations

This dissertation encompasses three articles concerning Sawyer's (2007) theory of group flow in the context of higher education, including a literature review, and two interpretive studies. In the literature review and in the first interpretive research article, the results of the research illuminated the applicability of themes of group flow in collaborative settings in higher education in themes of vision, ownership and contribution, and communication. The final article provides a description of the roles of student lead and professor in this environment and the unique ways that they may have encouraged those themes in the studio. The context for this …


Comparison Of Iron Supplementation And Albendazole On Anemia In Ghanaian Children, Megan M. Zitting Jul 2016

Comparison Of Iron Supplementation And Albendazole On Anemia In Ghanaian Children, Megan M. Zitting

Theses and Dissertations

Half a billion school aged children suffer from anemia, with the majority of anemia caused by iron deficiency. Researchers have shown a strong correlation between low hemoglobin levels and presence of intestinal parasites in children with anemia. Childhood anemia has profound negative effects on physical growth, maturation, and cognitive development leading to poorer educational achievement. Using hemoglobin as a measure of anemia, this quasi-experimental study investigated impact of either iron supplementation or an antiparasitic medication on hemoglobin levels in two groups of children in a rural region of Eastern Ghana. Surprisingly, after a 6-month intervention period, hemoglobin levels in both …


Story Retell Narratives In Five School-Aged Children With Language Impairment, Megan Bradshaw Deere Jul 2016

Story Retell Narratives In Five School-Aged Children With Language Impairment, Megan Bradshaw Deere

Theses and Dissertations

Many children identified with Language Impairment (LI) demonstrate difficulty comprehending and producing narratives. Their narratives are often structurally less complex and of overall poorer quality than those produced by their typically developing peers. These difficulties may negatively impact the academic and social success of children with LI. This thesis evaluates the performance of five school-aged children with LI on a story retell probe embedded within an intervention designed to address their social and emotional language abilities. During the 10-week intervention, participants completed a series of story retell probes using wordless picture books. The story stimuli were taken from the Edmonton …


Anal Fin Pigmentation In Brachyrhaphis Fishes Is Not Used For Sexual Mimicry, Kandace Mary Hugentobler Jul 2016

Anal Fin Pigmentation In Brachyrhaphis Fishes Is Not Used For Sexual Mimicry, Kandace Mary Hugentobler

Theses and Dissertations

Pigmentation patterns can be used as a communication signal in a variety of taxa, and can convey information relative to sexual selection, dominance, and species identification. Pigmentation is also sometimes used in mimicry to deceive the signal receiver into thinking the signaler is something other than itself. Mimicry can occur in several contexts, including sexual interactions, where one sex mimics another. There are relatively few examples of species with females that mimic males. Proposed hypotheses to explain female mimicry of males are that mimicry is used to reduce male harassment or that mimicry is used to display dominance over other …


The Activity Of Alkaline Glutaraldehyde Against Bacterial Endospores And Select Non-Enveloped Viruses, Justen Thalmus Despain Jul 2016

The Activity Of Alkaline Glutaraldehyde Against Bacterial Endospores And Select Non-Enveloped Viruses, Justen Thalmus Despain

Theses and Dissertations

Alkaline glutaraldehyde (GTA) has been used as a high level chemical disinfectant and sterilant for many years and is known to kill a broad spectrum of organisms ranging from vegetative eukaryotes to bacterial endospores. Although the mechanism of sporicidal action has been studied on numerous occasions, GTA's exact mechanism(s) of action are still debated. In addition to the uncertainty of GTA's mechanism(s) of action, GTA has also shown significant variability in the time required to kill endospores and naked viruses. A better knowledge of the lethal mechanism(s) of GTA is needed to understand this discrepancy in kill times for GTA …


Interconnectedness, Complicity And Ambiguity: Reading With Dark Ecology, Rachel Dene Whipple Jul 2016

Interconnectedness, Complicity And Ambiguity: Reading With Dark Ecology, Rachel Dene Whipple

Theses and Dissertations

There are many aspects of ecological thinking. When reading texts through a lens of dark ecology, certain conflicts that arise from the imposition of human expectations on natural systems are revealed. These include interconnectedness, complicity, and ambiguities. Within a system, boundaries are contingent and transitory. Beginnings and ends are gradual, not definite. Ecological systems change over time, but it is a category error to imagine that change represents progress or to assume a teleological purpose. While there are hierarchies of power, and different roles, no species is, ecologically speaking, more advanced than another. Ecological criticism focuses on interconnectedness, complicity, and …


Phonetic Shift /Ɔr/ Phonemic Change? American English Mergers Over 40 Years, Joseph A. Stanley, Margaret E. L. Renwick Jul 2016

Phonetic Shift /Ɔr/ Phonemic Change? American English Mergers Over 40 Years, Joseph A. Stanley, Margaret E. L. Renwick

Faculty Publications

In this paper we analyze the vowel formants of a speaker over four decades to show phonemic change through time. Other real-time studies (Harrington, Palethorpe & Watson 2000; Harrington & Reubold 2015) have found that the vowel spaces of UK English speakers shift over the lifetime, likely as a consequence of interaction with speakers of other dialects or social classes. We focus on an understudied variety of English, spoken in the western United States, to investigate a pair of phonological mergers, the cord-card merger and the hoarse-horse merger.


Book Review: Creating Wilderness: A Transnational History Of The Swiss National Park, Evan C. Rothera Jun 2016

Book Review: Creating Wilderness: A Transnational History Of The Swiss National Park, Evan C. Rothera

Swiss American Historical Society Review

No abstract provided.


The Tettigoniidae (Orthoptera: Ensifera): Phylogeny, Origins, And Leaf-Like Crypsis, Joseph D. Mugleston Jun 2016

The Tettigoniidae (Orthoptera: Ensifera): Phylogeny, Origins, And Leaf-Like Crypsis, Joseph D. Mugleston

Theses and Dissertations

Tettigoniidae (katydids) has more than 7200 species and is the largest family within the insect order Orthoptera. Their unique biology including leaf-like crypsis, acoustic signaling, and courtship rituals garners much of their academic attention. However, the taxonomy of katydids is chaotic and previous to these studies, little work had been done to decipher the phylogenetic relationships within this family. Without a robust phylogenetic framework, questions regarding the evolution of katydid disguises including the leaf-like crypsis cannot be addressed. This dissertation contains three chapters. Chapter 1 provides the first phylogenetic hypothesis focusing on Tettigoniidae. In this chapter we show a character …


Carl Jung's Historic Place In Psychology And Continuing Influence In Narrative Studies And American Popular Culture, Emily S. Darowski, Joseph J. Darowski Jun 2016

Carl Jung's Historic Place In Psychology And Continuing Influence In Narrative Studies And American Popular Culture, Emily S. Darowski, Joseph J. Darowski

Swiss American Historical Society Review

Cart Gustav Jung was a Swiss-born psychiatrist who lived from the late nineteenth century well into the twentieth century. He founded the analytical psychology movement and is known for ideas such as the collective unconscious, archetypes, and one of the first conceptions of introversion and extraversion. The following paper explores Jung's influence on the field of psychology and other disciplines, postulating that his more lasting, but subtle influence exists outside his chosen field. This topic for exploration developed out of conversations between the two authors, one with an educational background in cognitive psychology, the other in American Studies. We draw …


The Pilgrimage To Meaning Along The Camino De Santiago, Matthew Carey Greenhalgh Jun 2016

The Pilgrimage To Meaning Along The Camino De Santiago, Matthew Carey Greenhalgh

Theses and Dissertations

As Christianity spread throughout the Iberian Peninsula during the Middle Ages, many believers attributed miraculous tales to the Virgin Mary and saints. In Camino de Santiago folklore, the Virgin Mary and Saint James intercede on behalf of pilgrims who cannot resolve a crisis without divine assistance. The Codex Calixtinus, a twelfth-century manuscript, contains such a story that occurs in Toulouse called "The Hanged Pilgrim." In this miracle, an innkeeper frames a pilgrim for theft and the local magistrate sentences the accused to hang as a consequence. However, the Virgin Mary and Saint James spare the pilgrim's life because of his …


The Effects Of A Social Communication Intervention On The Production Of Emotion Words For Children With Language Impairment, Emilee Anne Longmore Jun 2016

The Effects Of A Social Communication Intervention On The Production Of Emotion Words For Children With Language Impairment, Emilee Anne Longmore

Theses and Dissertations

Many school-age children with a diagnosis of Language Impairment (LI) also have social communication difficulties. Some of these difficulties are related to deficits in emotion understanding. This thesis evaluates the effects of a social communication intervention designed to increase the production of emotion-based words as an indicator of emotional competence. For five elementary school-aged children with LI, the production of emotion-based words was analyzed by first determining the frequency of words produced in preintervention sessions for the following categories: happiness, sadness, anger, fear, surprise, and disgust. Following these measures, the participants received 20 intervention sessions over the course of treatment. …


U.N.I.T.Y. Addressing Misogyny And Transcending The Sista-Ho Dichotomy In Hip Hop Culture, Michael H. Easterling Jun 2016

U.N.I.T.Y. Addressing Misogyny And Transcending The Sista-Ho Dichotomy In Hip Hop Culture, Michael H. Easterling

Theses and Dissertations

In this thesis I investigate the portrayal of women in Hip Hop as either a sista' or a ho, a dichotomy that mirrors the Freudian Madonna-whore complex prevalent in Western Society. Belittled and disparaged by the sexism implied by this dichotomy, women have become victims of various forms of misogynistic abuse. Queen Latifah stands up against this misogyny, using Hip Hop in the very way it was designed to be used “as a voice for the disenfranchised“ speaking out against the sexism in Hip Hop in the same way African American males use Hip Hop against White mainstream society. She …


Shakespeare, Orson Welles, And The Hermeneutics Of The Archive, Benjamin Lynn Wagner Jun 2016

Shakespeare, Orson Welles, And The Hermeneutics Of The Archive, Benjamin Lynn Wagner

Theses and Dissertations

This paper examines certain theoretical underpinnings of the historical processes by which Shakespeare's history plays became the de facto collective memory of the events they depict, even when those events are misrepresented. The scholarly conversation about this misrepresentation has heretofore centered on Shakespeare's potential political motivations. I argue that this focus on a political, authorial intent has largely ignored the impact these historical distortions have had over the subsequent 400 years. I propose that, due to Shakespeare's unique place in the historical timeline of the development of collective memory, Shakespeare's historical misrepresentation in the history plays is a byproduct of …


Glutamate And Gaba Receptor-Mediated Plasticity In The Mesolimbic Dopamine System By Alcohol, Ashley Cerise Nelson Jun 2016

Glutamate And Gaba Receptor-Mediated Plasticity In The Mesolimbic Dopamine System By Alcohol, Ashley Cerise Nelson

Theses and Dissertations

Alcoholism is a devastating chronic relapsing disorder with significant costs to individuals and society. The mesolimbic dopamine (DA) system plays an important role in regulating reward and addiction. GABA neurons located in the ventral tegmental area (VTA) regulate VTA DA neuron activity, and are a relevant target for alcohol in the brain. VTA GABA neurons exhibit marked hyperexcitability during withdrawal from ethanol. Past research has demonstrated that the motivational effects of opiates cause a change in VTA GABA(A) receptors in opiate-dependent animals, which switch from a GABA-induced hyperpolarization of GABA neurons to a GABA-induced depolarization. The focus of this study …