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Relationship Between The Excited State Relaxation Paths Of Rhodopsin And Isorhodopsin, Angela Strambi, Pedro B. Coto, Luis Manuel Frutos, Nicolas Ferre, Massimo Olivucci Mar 2008

Relationship Between The Excited State Relaxation Paths Of Rhodopsin And Isorhodopsin, Angela Strambi, Pedro B. Coto, Luis Manuel Frutos, Nicolas Ferre, Massimo Olivucci

Chemistry Faculty Publications

The pigment Isorhodopsin, an analogue of the visual pigment Rhodopsin, is investigated via quantum-mechanics/molecular-mechanics computations based on an ab initio multiconfigurational quantum chemical, treatment. The limited <5 kcal mol(-1) error found for the spectral parameters allows for a nearly quantitative analysis of the excited-state structure and reactivity of its 9-cis-retinal chromophore. We demonstrate that, similar to Rhodopsin, Isorhodopsin features a shallow photoisomerization path. However, the structure of the reaction coordinate appears to be reversed. In fact, while the coordinate still corresponds to an asynchronous crankshaft motion, the dominant isomerization component involves a counterclockwise, rather than clockwise, twisting of the 9-cis bond. Similarly, the minor component involves a clockwise, rather than counterclockwise, twisting of the 11-trans bond. Ultimately, these results indicate that Rhodopsin and Isorhodopsin relax along a common excited-state potential energy valley starting from opposite ends. The fact that the central and lowest energy region of such valley runs along a segment of the intersection space between the ground and excited states of the protein explains why the pigments decay at distinctive conical intersection structures.


Board Of Trustees Meeting Minutes 2008-02-29, Bowling Green State University Feb 2008

Board Of Trustees Meeting Minutes 2008-02-29, Bowling Green State University

Board of Trustees Meeting Minutes

The official meeting minutes of Bowling Green State University's Board of Trustees.


The Bg News February 29, 2008, Bowling Green State University Feb 2008

The Bg News February 29, 2008, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. February 29, 2008. Volume 98-Issue 115.


The Bg News February 27, 2008, Bowling Green State University Feb 2008

The Bg News February 27, 2008, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. February 27, 2008. Volume 98-Issue 113.


The Bg News February 26, 2008, Bowling Green State University Feb 2008

The Bg News February 26, 2008, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. February 26, 2008. Volume 98-Issue 112.


The Bg News February 25, 2008, Bowling Green State University Feb 2008

The Bg News February 25, 2008, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. February 25, 2008. Volume 98-Issue 111.


The Bg News February 22, 2008, Bowling Green State University Feb 2008

The Bg News February 22, 2008, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. February 22, 2008. Volume 98-Issue 110.


The Bg News February 20, 2008, Bowling Green State University Feb 2008

The Bg News February 20, 2008, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. February 20, 2008. Volume 98-Issue 108.


The Bg News February 19, 2008, Bowling Green State University Feb 2008

The Bg News February 19, 2008, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. February 19, 2008. Volume 98-Issue 107.


The Bg News February 18, 2008, Bowling Green State University Feb 2008

The Bg News February 18, 2008, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. February 18, 2008. Volume 98-Issue 106.


The Bg News February 12, 2008, Bowling Green State University Feb 2008

The Bg News February 12, 2008, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. February 12, 2008. Volume 98-Issue 102.


Monitor Newsletter February 11, 2008, Bowling Green State University Feb 2008

Monitor Newsletter February 11, 2008, Bowling Green State University

Monitor

Official Publication of Bowling Green State University for Faculty and Staff


The Bg News February 5, 2008, Bowling Green State University Feb 2008

The Bg News February 5, 2008, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. February 5, 2008. Volume 98-Issue 97.


Monitor Newsletter February 04, 2008, Bowling Green State University Feb 2008

Monitor Newsletter February 04, 2008, Bowling Green State University

Monitor

Official Publication of Bowling Green State University for Faculty and Staff


The Bg News February 4, 2008, Bowling Green State University Feb 2008

The Bg News February 4, 2008, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. February 4, 2008. Volume 98-Issue 96.


Dynamics In The Transient Complex Of Plastocyanin-Cytochrome F From Prochlorothrix Hollandica, Rinske Hulsker, Maria Baranova, George S. Bullerjahn, Marcellus Ubbink Feb 2008

Dynamics In The Transient Complex Of Plastocyanin-Cytochrome F From Prochlorothrix Hollandica, Rinske Hulsker, Maria Baranova, George S. Bullerjahn, Marcellus Ubbink

Biological Sciences Faculty Publications

The nature of transient protein complexes can range from a highly dynamic ensemble of orientations to a single well-defined state. This represents variation in the equilibrium between the encounter and final, functional state. The transient complex between plastocyanin (Pc) and cytochrome f (cyt of the cyanobacterium Prochlorothrix hollandica was characterized by NMR spectroscopy. Intermolecular pseudocontact shifts and chemical shift perturbations were used as restraints in docking calculations to determine the structure of the wild-type Pc-cytf complex. The orientation of Pc is similar to orientations found in Pc-cytf complexes from other sources. Electrostatics seems to play a modest role in complex …


The Bg News January 30, 2008, Bowling Green State University Jan 2008

The Bg News January 30, 2008, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. January 30, 2008. Volume 98-Issue 93.


The Bg News January 28, 2008, Bowling Green State University Jan 2008

The Bg News January 28, 2008, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. January 28, 2008. Volume 98-Issue 91.


The Bg News January 24, 2008, Bowling Green State University Jan 2008

The Bg News January 24, 2008, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. January 24, 2008. Volume 98-Issue 89.


The Bg News January 22, 2008, Bowling Green State University Jan 2008

The Bg News January 22, 2008, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. January 22, 2008. Volume 98-Issue 87.


Monitor Newsletter January 21, 2008, Bowling Green State University Jan 2008

Monitor Newsletter January 21, 2008, Bowling Green State University

Monitor

Official Publication of Bowling Green State University for Faculty and Staff


The Bg News January 18, 2008, Bowling Green State University Jan 2008

The Bg News January 18, 2008, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. January 18, 2008. Volume 98-Issue 86.


The Bg News January 17, 2008, Bowling Green State University Jan 2008

The Bg News January 17, 2008, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. January 17, 2008. Volume 98-Issue 85.


The Bg News January 15, 2008, Bowling Green State University Jan 2008

The Bg News January 15, 2008, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. January 15, 2008. Volume 98-Issue 83.


Monitor Newsletter January 14, 2008, Bowling Green State University Jan 2008

Monitor Newsletter January 14, 2008, Bowling Green State University

Monitor

Official Publication of Bowling Green State University for Faculty and Staff


The Bg News January 14, 2008, Bowling Green State University Jan 2008

The Bg News January 14, 2008, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. January 14, 2008. Volume 98-Issue 82.


The Bg News January 11, 2008, Bowling Green State University Jan 2008

The Bg News January 11, 2008, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. January 11, 2008. Volume 98-Issue 81.


The Bg News January 10, 2008, Bowling Green State University Jan 2008

The Bg News January 10, 2008, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. January 10, 2008. Volume 98-Issue 80.


The Bg News January 9, 2008, Bowling Green State University Jan 2008

The Bg News January 9, 2008, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. January 9, 2008. Volume 98-Issue 79.


The Bg News January 8, 2008, Bowling Green State University Jan 2008

The Bg News January 8, 2008, Bowling Green State University

BG News (Student Newspaper)

The BGSU campus student newspaper. January 8, 2008. Volume 98-Issue 78.