Digital Commons Network^™

C-Dem Partner Forum May 4, 2020, Consortium On Electoral Democracy

Meeting Notes

No abstract provided.

Development Of A Novel Method For The Quantification Of Tyrosine 39 Phosphorylated Α- And Β-Synuclein In Human Cerebrospinal Fluid, Chan Hyun Na, Gajanan Sathe, Liana S. Rosenthal, Abhay R. Moghekar

Open Access archive

Background: Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder. Biomarkers that can help monitor the progression of PD or response to disease-modifying agents will be invaluable in making appropriate therapeutic decisions. Further, biomarkers that could be used to distinguish PD from other related disorders with PD-like symptoms will be useful for accurate diagnosis and treatment. C-Abl tyrosine kinase is activated in PD resulting in increased phosphorylation of the tyrosine residue at position 39 (Y39) of α-synuclein (α-syn) (pY39 α-syn), which contributes to the death of dopaminergic neurons. Because pY39 α-syn may be pathogenic, monitoring pY39 α-syn could allow …

2020-05-03_Michigandaily_Covidmap, Michigan Department Of Health & Human Services

Daily Michigan COVID-19 Update

The "WHERE WE STAND WITH COVID-19" map was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily at 3p.m., Monday - Saturday.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled.

The image contained a map, indicating total cases by county, and also provides statistics on Total Confirmed Cases, Total COVID-19 Deaths, Daily Confirmed Cases, and Daily COVID-19 Deaths. There …

2020-05-03_Michiganoverview_Covidcounts, Michigan Department Of Health & Human Services

Michigan COVID-19 Confirmed Cases by Date of Onset Data

Data was captured from the Cumulative Data link of Michigan's Coronavirus webpage, under the url https://www.michigan.gov/coronavirus/0,9753,7-406-98163_98173_99207---,00.html.

The website contained the table Count of Confirmed COVID-19 Cases by Date of Onset , sorted by Michigan Preparedness Region. It also contained 18 charts, including the count of confirmed Covid-19 cases by date of onset in the state overall as well as in each preparedness region,and the normalized rate of Covid-19 cases per 1,000,000 residents in both the state and in each preparedness region.

The Ability Of Thaumoctopus Mimicus To Be Operantly Conditioned To A Sound Stimulus, Stephanie Wittman

Honors Projects

This paper focuses on the ability of the mimic octopus Thaumoctopus mimicus to be operantly conditioned to an auditory stimulus. The octopus is known to be the most advanced of the invertebrates and has learning abilities that are comparable to vertebrates in spite of their differences in brain structure. These animals have been shown to react to visual and tactile stimuli and can be operantly conditioned to perform behaviors to obtain a food reward. The goal of this experiment is to determine whether the octopus can be operantly conditioned to swim into a box on the side of its tank …

2020-05-02_Michiganoverview_Covidcounts, Michigan Department Of Health & Human Services

Michigan COVID-19 Confirmed Cases by Date of Onset Data

Data was captured from the Cumulative Data link of Michigan's Coronavirus webpage, under the url https://www.michigan.gov/coronavirus/0,9753,7-406-98163_98173_99207---,00.html.

The website contained the table Count of Confirmed COVID-19 Cases by Date of Onset , sorted by Michigan Preparedness Region. It also contained 18 charts, including the count of confirmed Covid-19 cases by date of onset in the state overall as well as in each preparedness region,and the normalized rate of Covid-19 cases per 1,000,000 residents in both the state and in each preparedness region.

2020-05-02_Michigandaily_Covidmap, Michigan Department Of Health & Human Services

Daily Michigan COVID-19 Update

The "WHERE WE STAND WITH COVID-19" map was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily at 3p.m., Monday - Saturday.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled.

The image contained a map, indicating total cases by county, and also provides statistics on Total Confirmed Cases, Total COVID-19 Deaths, Daily Confirmed Cases, and Daily COVID-19 Deaths. There …

2020-05-02_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

Data Supporting The Paper "The Role Of Turbulent Fluctuations In Aerosol Activation And Cloud Formation", Prasanth Prabhakaran, Abu Sayeed Md Shawon, Greg Kinney, Subin Thomas, Will Cantrell, Raymond Shaw

Data Files

This data supports the following paper:

Prasanth Prabhakaran, Abu Sayeed Md Shawon, Gregory Kinney, Subin Thomas, Will Cantrell and Raymond A. Shaw, “The role of turbulent fluctuations in aerosol activation and cloud formation”, Proceedings of the National Academy of Sciences (2020), in review.

Plasmid Dna Upstream Manufacturing Process Development, Shaquil Janif

Creative Activity and Research Day - CARD

The need to develop a robust method to produce large quantities of plasmid DNA has become vital due to the strides made in the field of gene therapy. More and more biopharmaceutical companies are starting to produce gene therapeutics to treat diseases at the molecular level. While the technology has been proven to work and success at treating disease using gene therapeutics have been made in clinical trials, a method to produce large quantities of DNA still remains a challenge. In this presentation, I will go over some of the current challenges associated with producing high copy numbers of plasmid …

2020-05-01_Michiganoverview_Covidsymptoms, Michigan Department Of Health & Human Services

Michigan COVID-19 Syndromic Surveillance System Data

The Syndromic Surveillance System Data report was obtained from Michigan's COVID-19 dashboard, from under the link "​Coronavirus Symptoms": https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily.

Syndromic Surveillance System data is obtained from approximately 183 facilities participating in syndromic surveillance (132 Emergency Departments (ED), 51 Urgent Cares) across the State of Michigan. The reporting is based on individuals who present at EDs and may not be representative of the overall population. The coronavirus-like symptoms query searches visit free-text (chief complaint, triage notes, and clinical impression) for fever or …

2020-05-01_Michiganoverview_Covidcounts, Michigan Department Of Health & Human Services

Michigan COVID-19 Confirmed Cases by Date of Onset Data

Data was captured from the Cumulative Data link of Michigan's Coronavirus webpage, under the url https://www.michigan.gov/coronavirus/0,9753,7-406-98163_98173_99207---,00.html.

The website contained the table Count of Confirmed COVID-19 Cases by Date of Onset , sorted by Michigan Preparedness Region. It also contained 18 charts, including the count of confirmed Covid-19 cases by date of onset in the state overall as well as in each preparedness region,and the normalized rate of Covid-19 cases per 1,000,000 residents in both the state and in each preparedness region.

Arachidonic Acid Inhibits Inflammatory Responses By Binding To Myeloid Differentiation Factor-2 (Md2) And Preventing Md2/Toll-Like Receptor 4 Signaling Activation, Yali Zhang, Hongjin Chen, Wenxin Zhang, Yan Cai, Peiren Shan, Di Wu, Bing Zhang, Hui Liu

Paediatrics Publications

Arachidonic acid (AA) plays a fundamental role in the function of all cells. Metabolites of AA contribute to inflammation as well as for resolving inflammation. Although AA-derived metabolites exhibit well-substantiated bioactivity, it is not known whether AA regulates inflammatory responses independent of its metabolites. With the recent discovery that saturated fatty acids activate toll-like receptor-4 (TLR4), we tested the hypothesis that AA directly regulates inflammatory responses through modulating the activity of TLR4. In cultured cardiomyocytes and macrophages, we found that AA prevents saturated fatty acid-induced TLR4 complex formation with accessory proteins and the induction of proinflammatory cytokines. We discovered that …

Exploring The Use Of The Verbal Intelligence Quotient As A Proxy For Language Ability In Autism Spectrum Disorder, Leticia Ribeiro De Oliveira, Jessica Brian, Elizabeth Kelley, Deryk Beal, Robert Nicolson, Stelios Georgiades, Alana Iaboni, Susan Day Fragiadakis

Paediatrics Publications

Background: There is growing interest in understanding the brain and language associations in Autism Spectrum Disorder (ASD). A considerable number of studies investigating these associations have used the verbal intelligence quotient (VIQ) as their primary measure of language form and content. Given this current trend, we aimed to establish whether the VIQ could reliably be used as a measure of receptive and expressive language form and content in individuals with ASD and in typical development (TD). Method: We examined the VIQ standard scores derived from a Wechsler cognitive battery as well as receptive and expressive language standard scores from the …

Exploration Of Small-Molecule Entry Disruptors For Chikungunya Virus By Targeting Matrix Remodelling Associated Protein, Avinash Kumar, Ekta Rathi, Suvarna Ganesh Kini

Open Access archive

Background and purpose: A genome-wide clustered regularly interspaced short palindromic repeatsassociated protein 9-based screen has revealed that the cell adhesion molecule matrix remodelling associated protein 8 (Mxra8) acts as an entry mediator for many alphaviruses including chikungunya virus. The first Xray crystal structure reported for Mxra8 a few months ago has a low-resolution of 3.49Å. Experimental approach: Homology modelling of Mxra8 protein was done employing the SWISS-MODEL and PRIME module of Maestro. To design novel Mxra8 inhibitors pharmacophore guided fragment-based drug design and structure-based virtual screening of Food and Drug Administration approved drug libraries were undertaken. Molecular docking and molecular …

The Influence Of The Suture-Less Anterior Releasing Incision In A Triangular Flap Design On Postoperative Healing Following Surgical Removal Of Impacted Mandibular Third Molars, Sunil S. Nayak, Anushka Arora, Ashmeet Shah, Amee Sanghavi

Open Access archive

Objectives: The objective of this study was to determine the effect of suture-less anterior releasing incisions on postoperative wound healing following surgical removal of impacted mandibular third molars. Materials and Methods: A total of 112 patients were included in the study. Group 1 had 56 patients in which the anterior releasing incision was not sutured postoperatively, and group 2 had 56 patients, in whom the anterior releasing incision was sutured. The two groups were compared in terms of pain, swelling, and trismus at 1 day, 3 days, and 7 days postoperatively. The Univariate Type III Repeated-Measures ANOVA Assuming Sphericity was …

Age-Related Histological Changes In Vena Caval System Of Human Foetus And Adult: A Comparative Study, Robert Kevin Fernandez, Chandni Gupta, Sneha Guruprasad Kalthur

Open Access archive

Background: It has been documented that cardiac musculature is present in both venae cavae, and they contract together with the atrium, contributing to the pumping mechanism of the heart. So, in the present study, we measured the relative thicknesses of the three histological layers at formation, termination and intermediate levels of the venae cavae along with their histological characteristics. Materials and Methods: Ten foetal and 10 adult cadavers were used. The Superior and Inferior Venae Cavae from all three regions were excised and processed for histology. The qualitative and quantitative features of the vessels were observed and recorded. The data …

Work-Related Musculoskeletal Pain And Its Self-Reported Impact Among Practicing Dentists In Puducherry, India, Kuldeep Shekhawat, Arunima Chauhan, S. Sakthidevi, Basavaraj Nimbeni

Open Access archive

Work-related musculoskeletal pain (MSPs) is not uncommon among dentist and often limits their work efficiency impacting their quality of life. The present research was conducted to identify site-specific pain resulting from musculoskeletal disorders (MSDs) among practicing dentists and determine its impact on their quality of life. Setting and Design: A cross-sectional questionnaire study conducted among practicing dentists of Puducherry Taluk, Puducherry, India. Method and Materials: A closed-ended, self-administered questionnaire was distributed to 95 practicing dentists to identify site-specific MSP from the study subjects. Data on pain due to MSDs, frequency of pain, its impact on quality of life, relieving factors, …

Loss Of Prss56 Function Leads To Ocular Angle Defects And Increased Susceptibility To High Intraocular Pressure, Cassandre Labelle-Dumais, Goutham Pyatla, Seyyedhassan Paylakhi, Nicholas G. Tolman

Open Access archive

Glaucoma is a leading cause of blindness, affecting up to 70 million people worldwide. High intraocular pressure (IOP) is a major risk factor for glaucoma. It is well established that inefficient aqueous humor (AqH) outflow resulting from structural or functional alterations in ocular drainage tissues causes high IOP, but the genes and pathways involved are poorly understood. We previously demonstrated that mutations in the gene encoding the serine protease PRSS56 induces ocular angle closure and high IOP in mice and identified reduced ocular axial length as a potential contributing factor. Here, we show that Prss56−/− mice also exhibit an abnormal …

Problems In Using Whatsapp Groups For Survey Research, Shahul Ameen, Samir Kumar Praharaj

Open Access archive

No abstract provided.

Multidrug-Resistant Pseudomonas Aeruginosa Evokes Differential Inflammatory Responses In Human Microglial And Retinal Pigment Epithelial Cells, Poonam Naik, Sukhvinder Singh, Sushma Vishwakarma, Inderjeet Kaur

Open Access archive

Increasing incidences of multidrug-resistant (MDR) pathogens causing endophthalmitis threaten our ability to treat this condition, and the modulation of inflammatory responses by MDR bacteria is not known. In this study, using human microglia and retinal pigment epithelial (RPE) cells, we compare the inflammatory responses of sensitive (S-PA) and multidrug-resistant (MDR-PA) clinical isolates of Pseudomonas aeruginosa. Infected cells were subjected to qPCR analysis, enzyme-linked immunosorbent assay (ELISA), and immunostaining to assess the expression of inflammatory mediators. Both microglia and RPE cells, challenged with S-PA and MDR-PA, induced a time-dependent expression of inflammatory cytokines. Significant differences were observed in expression levels of …

Digital Transformation And Governance Innovation For Public Biobanks And Free/Libre Open Source Software Using A Blockchain Technology, Nikolaos Evangelatos, Sudhakara P. Upadya, Julien Venne, Kapaettu Satyamoorthy

Open Access archive

Digitalization and digital health are transforming research practices, while economic growth is increasingly driven by the information commons. In the case of biological sciences, information commons, such as public biobanks and free/libre open source software (FLOSS), are of paramount importance for both research and the bioeconomy. In a time of digitalization, however, information commons are vulnerable to violations, such as the free-rider problem, that render the commons unsustainable. Consequently, it has been argued that the enclosure of the informational common resources is the only means to effectively exploit them. Given the social and economic importance of the information commons, the …

Clinical Approaches To Interpreting The Findings Of Systematic Review And Meta-Analysis Of The Effectiveness Of Probiotics In The Prevention And Treatment Of Cancer Therapy-Induced Oral Mucositis (Ctiom), Rama Jayaraj, Chellan Kumaraswamy, Sameep Shetty, Greg Raymond

Open Access archive

No abstract provided.

2020-05-01_Michigandaily_Covidmap, Michigan Department Of Health & Human Services

Daily Michigan COVID-19 Update

The "WHERE WE STAND WITH COVID-19" map was obtained from Michigan's main COVID-19 page: https://www.michigan.gov/coronavirus. Data was compiled by the Michigan Department of Health and Human Services (MDHHS). The information was updated daily at 3p.m., Monday - Saturday.

The State of Michigan is working around the clock to test and treat COVID-19 patients. Below is the most recent data healthcare experts across the state have compiled.

The image contained a map, indicating total cases by county, and also provides statistics on Total Confirmed Cases, Total COVID-19 Deaths, Daily Confirmed Cases, and Daily COVID-19 Deaths. There …

Compact Recurrent Neural Networks For Acoustic Event Detection On Low-Energy Low-Complexity Platforms, Gianmarco Cerutti, Rahul Prasad, Alessio Brutti, Elisabetta Farella

Open Access archive

Outdoor acoustic event detection is an exciting research field but challenged by the need for complex algorithms and deep learning techniques, typically requiring many computational, memory, and energy resources. These challenges discourage IoT implementations, where an efficient use of resources is required. However, current embedded technologies and microcontrollers have increased their capabilities without penalizing energy efficiency. This paper addresses the application of sound event detection at the very edge, by optimizing deep learning techniques on resource-constrained embedded platforms for the IoT. The contribution is two-fold: firstly, a two-stage student-teacher approach is presented to make state-of-the-art neural networks for sound event …

Detection And Characterization Of Esblproducing Enterobacteriaceae From The Gut Of Healthy Chickens, Gallus Gallus Domesticus In Rural Nepal: Dominance Of Ctx-M-15-Non-St131 Escherichia Coli Clones, Supram Hosuru Subramanya, Indira Bairy, Niranjan Nayak, Rajesh Amberpet

Open Access archive

The surge in the prevalence of drug-resistant bacteria in poultry is a global concern as it may pose an extended threat to humans and animal health. The present study aimed to investigate the colonization proportion of extended-spectrum β-lactamase (ESBL) and carbapenemase- producing Enterobacteriaceae (EPE and CPE, respectively) in the gut of healthy poultry, Gallus gallus domesticus in Kaski district of Western Nepal. Total, 113 pooled rectal swab specimens from 66 private household farms and 47 commercial poultry farms were collected by systematic random sampling from the Kaski district in western Nepal. Out of 113 pooled samples, 19 (28.8%) samples from …

Antidiabetic Drug Metformin Affects The Developmental Competence Of Cleavage-Stage Embryos, Guruprasad Nayak, Sujith Raj Salian, Pooja Agarwal, Pooja Suresh Poojary

Open Access archive

Purpose: Metformin is the most commonly prescribed drug in the management of metabolic disorders such as polycystic ovarian syndrome (PCOS) and gestational diabetes in women of reproductive age. Insulin-sensitizing effect of metformin helps in improving from PCOS features such as hyperandrogenism, anovulation, and infertility. However, its ability to cross placental barrier raises concern about safety of the drug on early embryonic development. In this study, we evaluated the effect of metformin on the ovarian function and embryo development. Methods: Adult Swiss albino female mice were administered with metformin (0, 50, 100, and 200 mg/kg body weight) for 4 weeks and …

Ohpl Application: Diabetic Retinopathy, Ying Xie

DLPE Code

No abstract provided.

Widespread Army Ant Aversion Among East African Jumping Spiders (Salticidae), Ximena J. Nelson, Samuel Aguilar-Arguello, Robert R. Jackson

All Peer-Reviewed Publications

Jumping spiders (Salticidae) typically prey on a variety of arthropods of similar size to themselves, but rarely on ants. Using 28 salticid species from East Africa, we first investigated vision-based aversion to ants by recording latency to enter a transparent sealed chamber flanked by chambers containing living army ants (Dorylus sp.) or tsetse flies (Glossina pallidipes) of comparable size. For all species, entry latency was significantly longer when the stimuli were ants. In another experiment, we used dead ants and tsetse flies mounted in a life-like posture as stimuli; except for Goleba puella, a species with unusual retinal ultrastructure, we …

Cerebrovascular Function In Adults With Depression, Rauchelle Richey

Kinesiology Theses - Archive

Cerebral vasodilatory responsiveness is blunted in older adults (~45-70 yrs) with depressive disorders and thought to contribute to the link between depressive symptomology and increased risk for neurocognitive (e.g., dementia) and cerebral vascular (e.g., stroke) diseases. In young adults with major depressive disorder (MDD), peripheral vascular endothelial dysfunction is evident; however, to date, limited investigations have examined cerebral vasodilatory function in young healthy adults with MDD. We tested the hypothesis that cerebral vasodilatory responsiveness to a hypercapnic stimulus would be blunted in healthy young adults with MDD compared to healthy non-depressed adults (HA). Fourteen HA (22 ± 3yrs) and 14 …