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Microrna's – The Vibrant Performers In The Oral Cancer Scenario, Monica Charlotte Solomon, Raghu Anekal Radhakrishnan
Microrna's – The Vibrant Performers In The Oral Cancer Scenario, Monica Charlotte Solomon, Raghu Anekal Radhakrishnan
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MicroRNAs (miRNAs) are a family of small non-coding (18–22 nucleotide) RNA molecules. These molecules regulate gene expression by either inhibiting mRNA translation or by degrading mRNA. A single miRNA can control the expression of target genes, and the expression of a target gene can be regulated by multiple miRNAs. They are key regulators of various biological and pathological processes. These include cell proliferation, development and tumorigenesis. Novel studies have discovered definite signature miRNAs in the initiation and progression of cancers. Interestingly, miRNAs have also been found in fragile genomic sites that are associated with increased cancer risk. These micro RNAs …
Elucidating The Role Of Excision Repair Cross-Complement Group 1 In Oral Epithelial Dysplasia And Early Invasive Squamous Cell Carcinoma: An Immunohistochemical Study, Spoorti Kulkarni, Monica Solomon, Deepthi Pankaj, Sunitha Carnelio
Elucidating The Role Of Excision Repair Cross-Complement Group 1 In Oral Epithelial Dysplasia And Early Invasive Squamous Cell Carcinoma: An Immunohistochemical Study, Spoorti Kulkarni, Monica Solomon, Deepthi Pankaj, Sunitha Carnelio
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Objectives: Oral epithelial dysplasia (OED) is characterized by cellular alterations which have the proclivity of progressing to squamous cell carcinoma. Excision repair cross-complement group 1 (ERCC1) is one of the key proteins involved in nucleotide excision repair (NER) pathway. The expression of ERCC1 has been studied in colorectal, esophageal, ovarian and oral squamous cell carcinoma; but, very few studies have been done to apprehend the expression of ERCC1 in OED and early invasive squamous cell carcinoma (EISCC). The goal of this study is to evaluate the role of ERCC1 in OED and EISCC. Materials and Methods: Histopathologically diagnosed cases of …