Digital Commons Network^™

Natural Products In Food And Agriculture, Stephen O. Duke

Oxford ICSB

Before the National Center for Natural Products Research (NCNPR) existed, I was Director of a USDA weed management lab. Two of my interests were natural products as herbicides and the chemical ecology of weed/crop interactions (allelopathy). Dr. James McChesney and I had several conversations about his vision for the NCNPR on the University of Mississippi campus. I was very interested in becoming a part of this, as his plan was to have a USDA lab that would study natural products for use in food and agriculture as part of the center. The USDA Agricultural Research Service established the Natural Product …

Preventing Ingredient Adulteration To Maintain Botanical Integrity, Katie Banaszewski

Oxford ICSB

The growing popularity of botanical products combined with the challenges of the supply chain to meet the ingredient demand has created opportunities for dishonest companies to take advantage of their clients for financial gain. Suppliers and manufacturers must comply with cGMPs (current Good Manufacturing Practices), specifically when it comes to the basic requirements of properly identifying crude botanicals in whole, cut, or powdered form, as well as botanical extracts and essential oils. Despite this regulatory requirement, a large portion of botanical ingredients and products sold in the marketplace are adulterated. Popular ingredients in high demand are intentionally substituted, diluted, or …

African & Caribbean Herbal Pharmacopieae - Curating Data For Product Development, David Katerere

Oxford ICSB

This presentation aims to provide a comprehensive examination of the Africa Herbal Pharmacopoeia (AHP) and the Caribbean Herbal Pharmacopoeia (CHP), highlighting their respective similarities and differences in the realm of traditional herbal medicine and product development. Both pharmacopoeias are important initiatives in curating indigenous knowledge related to medicinal plants. They are valuable resources for researchers, healthcare practitioners, and industry. This presentation will outline the methodological and logistical approaches employed in putting together monographs and the challenges faced. Furthermore, the comparative analysis will explore the regional nuances that shape the content of each pharmacopoeia, considering factors such as local traditions, ecological …

Chemistry, Biology, And Safety Of Volatile Organics From Aromatic And Medicinal Plants, Nicole Stevens

Oxford ICSB

Introduction Sleep is an important foundation of health, yet the U.S. Centers for Disease Control (CDC) notes that about 30% of adults to not get the recommended minimum of 7 hours’ sleep per night. Prescription treatments may help, but they carry risks such as side-effects, dependency, and medication interaction. Natural botanical extracts are a therapeutic possibility for improving sleep quality, but additional research is needed on their efficacy and safety. A system of natural products based on lavender was developed and tested in a human clinical study to evaluate effect on sleep, blood and safety markers, and gene expression modulation …

Adulteration - Why Does It Still Proliferate?, John Travis

Oxford ICSB

No abstract provided.

A Survey Of Melatonin In Dietary Supplement Products Sold In The U.S., Rahul Pawar

Oxford ICSB

In the United States, melatonin products are widely available to consumers as dietary supplements. During the past few decades, melatonin products have gained increased popularity primarily as a sleep aid, with a variety of product forms available for different age groups of consumers. Recent reports have highlighted a rise in melatonin ingestion among children reported to poison control centers across the U.S. The increased use of melatonin-containing dietary supplements and reported deviation from labeled quantities has emphasized the need for additional research to better understand products in the marketplace.
The objective of this work was to measure the melatonin content …

Challenges Of Building Specifications For Essential Oils: An Industry Perspective, Brett Smith

Oxford ICSB

The rise in essential oil popularity is creating unprecedented demand worldwide. With the increased demand, the worldwide supply chain is challenged with maintaining consistent quality standards. Some essential oil producers may be motivated to use new and innovative methods to alter their products to meet quality standards and extend their current oil supplies. Climate change is also affecting growing season conditions, leading to changes in essential oil composition compared to past harvests. These factors create challenges for industry in establishing updated quality and commerce specifications beyond traditional ISO, AFNOR, and pharmacopoeia standards for essential oils. To meet these supply chain …

Characterization Of Ashwagandha Using A Multi-Detector Approach, Vincent Sica

Oxford ICSB

Botanicals are complex mixtures that present unique analytical challenges. A multi-detector chromatographic approach can provide accurate, constituent-based data to ensure proper identification and quantification of botanicals. These data are often used to help drive in silico safety assessments to identify suspected toxicants and assess the potential for deleterious effects using structure activity relationships. To showcase this approach, ashwagandha extracts were characterized to determine authenticity and to guide the necessary toxicological studies. To ensure the full constituency of the extracts are evaluated, a multi-detector system (UHPLC-PDA-CAD-HRMS) was employed and subjected to a comprehensive chemical constituent identification (CCID) process. All of the …

Understanding Plant To Extract Ratios Of Botanical Extracts And Their Implications In Product Labeling, Maria Monagas, Thomas Brendler, Josef Brinckmann, Steven Dentali, Stefan Gafner, Gabriel Giancaspro, Holly Johnson, James Kababick, Cuiying Ma, Hellen Oketch-Rabah, Pilar Pais, Nandu Sarma, Robin Marles

Oxford ICSB

Dietary supplement current good manufacturing practice (cGMP) in the U.S. requires the establishment of quality parameters for each component used in the manufacture of a dietary supplement to ensure that specifications for the identity, purity, strength, composition, and limits on contaminants are met using scientifically valid methods of analysis. However, specifications for botanical extracts (including fungal and algal extracts) routinely include additional data that are not amenable to verification through analytical methods. Such descriptive information may include Plant to Extract ratios, which are ratios of the quantity of botanical article used in the manufacture of the extract to the quantity …

The True History Of Aloes And Beyond, Ben-Erik Van Wyk

Oxford ICSB

The recorded history of aloes dates back thousands of years, with early recordings in the Papyrus Ebers (ca. 1550 B.C.) and in Dioscorides’s Herbal (1st cent. A.D.). Aloe has been used as a two-in-one medicine, not only by early explorers but also as a material of strategic military importance, with the yellow juice effective against the stomach problems of an army on the march and the white juice (gel) used to treat the wounds of battle. Aloe vera is the correct name for the “true aloe”, as the specific epithet “vera” indicates. The origins of the plant are shrouded in …

One-Class Modeling For The Authentication Of Actaea Racemosa And Evaluation Of The Variation Between Botanical Reference Materials, James Harnly

Oxford ICSB

One-class modeling based on soft independent modeling of class analogy (SIMCA) is a simple but powerful method for comparing the chemical composition of botanical materials using non-targeted chromatograms (GC, LC) or spectra (IR, MS, NIR, NMR). The methodology is available on any commercial chemometric platform. Authentication is based solely on the characteristics of the botanical material of interest. Detection of adulteration is determined for each variable and requires no identification of adulterants. Some highly characterized botanical reference materials (BRMs) may account for species, cultivar, and year and location of harvest while more generic BRMs may have minimal characterization. All of …

Development Of Teacher Training Program, Manual, & Curriculum Guide For Inclusive Dance Studio, From An Occupational Therapy Perspective, Susanna C. Dunn

OTD Capstone Projects

This capstone project was completed in collaboration with MOVE Inclusive Dance, a nonprofit, inclusive dance studio specifically serving individuals of all ages with various disabilities. A needs assessment conducted with the staff at MOVE necessitated a cohesive teacher manual, including teacher training protocol, disability index, safety precautions, sample class activities, curriculum guide, and more. The focus of this capstone was to create and distribute a teacher training manual to dance teachers at MOVE Inclusive Dance. The teacher training manual was created using anonymous pre and post test qualitative and quantitative surveys to assess teacher perceptions regarding feelings of confidence and …

Hannah Duston Timeline, Amanda M. Higham

The Hugemanities Project Big Contest

The controversy over whether Hannah Dunston is a hero or villain is widely debated, but here is an objective account of the timeline of events that occurred…

Genetic Analysis Of Microcystis Aeruginosa And Its Environmental Repercussions, Wilfrid L. Hufton

Undergraduate Research Conference

Toxic algal blooms pose an ever-present threat to the goals of commercial, conservational, and recreational aquatic interests. The microcystins produced by Microcystis aeruginosa are one of the primary contributors to the toxicity such blooms present. An examination of the global effects of Microcystis aeruginosa on the interests mentioned above, as well as the genetics of the NIES-2481 and NIES-843 strains, was conducted with the goal of generating a better understanding of the issues toxic algal blooms present and considering countermeasures to combat such blooms. Conclusions are presented regarding possible outcomes of apathy toward Microcystis aeruginosa and suggestions for the future …

Doxorubicin-Induced Nuclear Localization Of Scube3 Essential For Cell Survival In Tnbc, Ayooluwa Ilesanmi

Undergraduate Research Conference

Mediation of Doxorubicin-Induced SCUBE3 Nuclear Localization by A Functional NLS Involved in Pro-Tumorigenic Actions in Breast Cancer.

Signal peptide-CUB-EGF-like domain-containing protein 3 (SCUBE3) is a glycosylated secreted and cell membrane-associated protein considered a signature gene in cancers and known to mediate its actions in the cytoplasm where its localizes prior to its secretion. However, our study observed that SCUBE3 protein localized to the nucleus following doxorubicin (DOX) treatment. In this study, we investigated SCUBE3 nuclear localization in triple-negative breast cancer, intending to dissect the mechanism of its nuclear trafficking induced by DOX treatment. Bioinformatic analysis of the SCUBE3 protein sequence …

Upregulation Of The Predominant Cystic Fibrosis Causing Mutation Df508-Cftr By Triazole Compounds In Epithelial Cells, Maggie Taylor

Undergraduate Research Conference

Cystic fibrosis is a common genetic disease that is caused by a mutation in the plasma membrane protein CFTR, which stands for Cystic Fibrosis Transmembrane-conductance Regulator. When this membrane protein is mutated, it impairs its chloride ion channel function, blocking the movement of chloride ions that travel in and out of the cell. Previous studies have demonstrated that the most prevalent CFTR mutation, ∆F508-CFTR, can be partially reversed using small molecules (Heda and Marino, BBRC, 271:659-664, 2000). In this study, I have investigated the effects of several triazole compounds known to bind and transport chloride ions in cultured cells, on …

Review Of A Sexuality Education Video, Emily Perkins

Undergraduate Research Conference

The purpose of this study is essentially to act as a needs assessment for future learners. Students will be watching a sexuality education video on STIs, their preventions, and treatments from the early 2000s. Following the video, students will take a survey that allows them the opportunity to give feedback on the information that was presented to them and what was lacking in the video, as well as possible accessibility concerns. The results from this survey will be used to update both the information in the original video, as well as implementing the feedback we received from the first video …

Hse-8 The Revitalization Of The Hazel Green Academy, Josephine Traver, Jennifer M. Nguyen

SC Upstate Research Symposium

The Hazel Green Academy Revitalization Project is a community service-based project focused on restoring and repurposing the Hazel Green Academy (HGA). Established in 1880, HGA was a residential college-preparatory school located in Eastern Wolfe County, KY. At its height, HGA served not only as a school but also as a source of education and community events. Throughout the years, the academy expanded its facilities and resources to benefit both the students and the community. However, as free public schools emerged in the surrounding area during the 1930s, HGA faced a decline in enrollment. Consequently, HGA struggled for the next few …

Restoring Effective Sleep Time In Post Cardiac Surgery Patients: A Quality Improvement Project, Brooke Watts Bsn, Rn

Epsilon Sigma at-Large Research Conference

Purpose: Restoring Effective Sleep Time in Post Cardiac Surgery Patients: A Quality Improvement Project

Brooke Watts, BSN, RN, DNP Student, Murray State University

Dr. Kristin Reid, DNP, APRN, ACNS-BC, DNP Program Director/Assistant Professor Murray State University

Aims: This quality improvement project was developed using DNP project guidelines provided through Murray State University and was designed to improve sleep in hospitalized cardiac surgery patients.

Processes: IRB approval was obtained from the healthcare institution and academic institution. This two-phase quality improvement project was designed to analyze the effects of a change in normalized hospital routines on self-reported sleep in post-cardiac surgery patients. …

Development And Evaluation Of Trauma Informed Care Education For Licensed Nurses, Kristina O'Meara

Epsilon Sigma at-Large Research Conference

Trauma informed care nursing education is crucial. Trauma informed care is a method of providing health care which understands the likelihood of past and present traumatic events in patients and families. The experience of past or present trauma often led to chronic diseases, substance abuse disorder, fragmented health care, fears surrounding health care, chronic stress, and other negative health consequences. The purpose of this project is to increase licensed nurses’ awareness and ability to practice trauma informed care in clinical practice, as well as promote policy initiation within the health care facilities. Method planning integrated the Knowledge to Action Cycle. …

Will The Implementation Of Nurse Competency Days Improve Knowledge And Satisfaction In Nursing Staff Of A Community Health Center?, Christina Morton

Epsilon Sigma at-Large Research Conference

Background: Nursing competencies are important for quality of care, patient safety, and identifying gaps in knowledge and skills. Patient harm has been linked to a lack of competency and insufficient policy and procedures.

Purpose: The purpose of this quality improvement project was to achieve standardization of nursing competencies within nurse-led clinics.

Aims: The aims of this project were to validate select competency days and determine the satisfaction of the competency days by the participants. The second aim of this project was to develop an electronic tracking form. A third aim was to develop and present a policy and procedure …

Health Literacy And Diabetes Outcomes In Adults With Type 2 Diabetes In Southwest Virginia, Casandra Reyes Arellano

Epsilon Sigma at-Large Research Conference

Purpose: To determine if a quality improvement project involving individualized, one-on-one Diabetes education will improve health literacy and Diabetes outcomes in adults with Type 2 Diabetes in a rural primary care clinic. Diabetes is a chronic condition affecting the United States with 9.6% of Virginia’s population living with Diabetes.

Aims: To improve patient’s Diabetes literacy scores, BMI, and Hemoglobin A1c levels through Diabetes education.

Processes: There are pre- and post-education phases. Data to be collected at the end of both phases consist of DNT15 scores, BMI, and A1c. In the pre-education phase, BMI was obtained, DNT15 was administered, and Diabetes …

Implementation Of Provider-Made Follow-Up Appointments For Depression In Primary Care, Rebecca Vaughn

Epsilon Sigma at-Large Research Conference

Implementation of provider-made follow-up appointments for depression in primary care

Rebecca Vaughn

College of Nursing, East Tennessee State University; Whitson Hester School of Nursing, Tennessee Technological University

Author Note

Rebecca Vaughn https://orcid.org/0009-0007-0731-3316 College of Nursing, East Tennessee State University

There are no conflicts of interest to disclose.

Corresponding concerning this manuscript should be addressed to Rebecca Vaughn

108 Reed Mill Lane Monroe TN 38573

[email protected]

Abstract

Depression is a common condition diagnosed and managed in primary care.

Follow-up is inconsistent and low in these settings, creating a gap in care that

impacts management, adherence to treatment, and patient outcomes. The …

Maternal Morbidity In Appalachian States: Rural Disparities And Social Determinants, Kathryn Usedom Msn, Fnp-C, Cnm, Pi-Ming Yeh Phd

Epsilon Sigma at-Large Research Conference

Purpose: Social determinants of health (SDoH) and rurality have both been shown to contribute to severe maternal morbidity (SMM). Appalachian communities often embody this compounded risk, but regional SMM is under-explored. This study’s purpose is to explore SMM in rural areas of Appalachian states.

Aims: There are two specific aims. 1) Describe the prevalence of rural SMM in Appalachian states. 2) Investigate the relationship between SMM and SDoH, specifically income, education, and care access.

Methods: An IRB exempt, descriptive correlational study was conducted. Birth data (2018-2022) were extracted from the CDC WONDER database for 12 Appalachian states. Demographic, income, and …

Comparisons Of Spiritual Well-Being, Psychological Well-Being, And Suicidal Ideation Between Usa And Taiwanese College Students, Pi-Ming Yeh Associate Professor, Cheng-Huei Chiao Professor, Jennchang Liou Professor

Epsilon Sigma at-Large Research Conference

Background: In Taiwan, there were 7,038 reports of attempted suicide among people aged 24 or younger in 2018. Anxiety disorders are the most common mental illness in the U.S., affecting 40 million adults in the United States age 18 and older.

Purpose: In this study, we compared United States (US) and Taiwanese college students’ spiritual well-being, psychological well-being, and suicidal ideation.

Methods: A total of 661 college students (481 from the US and 180 from Taiwan) were recruited to complete the survey study. This was a cross-sectional comparative research design. SPSS 28.0 was used to do the data analysis. Chi-square …

Increasing Staffs’ Awareness Of Adaptive Swim Lesson Methodology And Enhancing Agency’S Infant Lesson Programming, Chloe E. Volpi

OTD Capstone Projects

This doctoral capstone project was conducted in partnership with Sunshine Swim Center, located in Elk Grove, CA. Sunshine is a small-scale swim lesson company that is proud to offer their community small class sizes and personalized swim instruction. The focus of this project was to educate agency staff on the importance of adaptive swim lessons for children with disabilities and enhance the current infant lesson programming. The staff education material included information on instruction modification, informal behavior modification, alternate forms of communication, cueing, skill grading, and the sensory properties of water. Enhancements to the infant programming included adding fifteen new …

A Parent's Guide To Pediatric Wheelchair Equipment, Gianna M. Sarli

OTD Capstone Projects

This capstone project was completed through a partnership with Permobil. Permobil is an assistive technology company that makes assistive technology solutions that enrich the lives of individuals with disabilities. They create a wide range of assistive technology products including power wheelchairs, manual wheelchairs, cushions, extremity supports, positioning equipment, and so much more. The focus of this project was to create the Content Brief for a pediatric landing page on their website. This webpage is focused on how Permobil products can support a child’s occupational participation and help them achieve their daily goals. The goal of this content was to have …

The Fight For Fluoridation In Stl, Noor Yousaf

Undergraduate Research Symposium

Fluoridation is the addition of fluoride to a source of drinking water. In St. Louis’s public water supply, the amount of fluoride remains the same since 1953 at 5ppm. Dr. Ralph Rosen and his team of dentists and researchers advocated for the fluoridation of the water because it reduced the frequency of dental caries occurring in children and adults alike, but the public had opinions on the sudden addition of chemicals to their water. This includes how the public’s health will be affected, how consumer products would change, and also how effective this addition of fluoride would be. This debate …

Service-Learning Through Chapter Chats: A Personal Reflection, Charity B. Blalock, Maryse Azer, April Garrity

Eagle Showcase: Excellence in Service-Learning (Archived)

Eagle showcase:excellence in service learning

Plane Of Existence: A Composition By An Sfa Percussionist, For The Sfa Percussion Ensemble, Carson Chlup

Undergraduate Research Conference

No abstract provided.