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Dimension Reduction Involving Exogenous Variables With Applications In Manufacturing And Healthcare, Linxi Li Jan 2026

Dimension Reduction Involving Exogenous Variables With Applications In Manufacturing And Healthcare, Linxi Li

Theses and Dissertations

High-dimensional data analysis presents diverse challenges, including the curse of dimensionality, the complexities of working with datasets that combine large feature spaces with limited sample sizes, and difficulties in identifying meaningful relationships among variables. As datasets grow in size and complexity across different fields, it is increasingly important to develop practical approaches for extracting essential information from such data. Dimension reduction methods address these challenges by alleviating the effects of high dimensionality, enhancing the ability to reveal hidden patterns, and uncovering latent structures within the data to support further analysis. Some methods reduce dimensionality while preserving all relevant information, offering …


An Integrated Data-Driven Framework For Arctic Shipping: Analyzing Vessel Speed, Environmental And Ecological Factors Through Innovative Statistical Spatio-Temporal Methods, Inverse Optimization And Machine Learning, Mauli Pant Jan 2026

An Integrated Data-Driven Framework For Arctic Shipping: Analyzing Vessel Speed, Environmental And Ecological Factors Through Innovative Statistical Spatio-Temporal Methods, Inverse Optimization And Machine Learning, Mauli Pant

Theses and Dissertations

This dissertation develops an integrated data-driven framework to analyze vessel navigation and ecological risk in the United States Arctic from 2010 to 2019. As environmental change and maritime activity increase in the region, understanding how vessels respond to dynamic conditions and how those responses interact with marine ecosystems has become increasingly important. A central theme of this dissertation is the treatment of vessel speed as both an observed outcome and a decision variable reflecting trade- offs among operational, environmental, and ecological factors. The first chapter develops a predictive framework for vessel speed over ground (SOG) using Gaussian Process Boosting (GPBoost), …


Machine Learning-Based Intrusion Detection System For Iot Networks Using The Rt-Iot 2022 Dataset, Bukunmi Ebenezer Afolabi Jan 2026

Machine Learning-Based Intrusion Detection System For Iot Networks Using The Rt-Iot 2022 Dataset, Bukunmi Ebenezer Afolabi

Theses, Dissertations and Capstones

The rapid expansion of the Internet of Things (IoT) has transformed modern computing by enabling seamless connectivity among heterogeneous devices across diverse application domains. However, this increased interconnectivity has significantly enlarged the attack surface of IoT networks, exposing them to a wide range of sophisticated cyber threats. Conventional security mechanisms often lack the capability to detect emerging attacks in real time, thereby necessitating the development of intelligent Intrusion Detection Systems (IDS) capable of accurately identifying malicious network activities. This study developed and evaluated a machine learning-based intrusion detection framework for multiclass IoT attack detection using the RT-IoT2022 dataset. The dataset …


Symbolic Logistic Regression For Interval-Valued Predictors: A Simulation Study And Application To Health Data, Soad Abdullah Jan 2026

Symbolic Logistic Regression For Interval-Valued Predictors: A Simulation Study And Application To Health Data, Soad Abdullah

Graduate Research Theses & Dissertations

This thesis investigates symbolic logistic regression for interval-valued predictors through simulation studies and a real health data application. Classical logistic regression assumes exact predictor values, whereas in many practical settings variables are available only in interval form due to coarsening or reporting uncertainty. Two simulation studies examine the impact of interval uncertainty under asymmetric intervals and measurement error. Symbolic models based on midpoint and midpoint-plus-width representations are compared with the classical approach. Results show that midpoint modeling captures the general relationship but introduces bias under asymmetry, while incorporating width reduces this distortion. Under measurement error, classical logistic regression exhibits attenuation …


Bayesian Inference For A 12-Level Galton Board Using Terminal Bin Counts, Ace Frieders Jan 2026

Bayesian Inference For A 12-Level Galton Board Using Terminal Bin Counts, Ace Frieders

Graduate Research Theses & Dissertations

A Galton board is a physical device in which a ball passes through a triangular array of pegs and is deflected left or right before landing in one of several bins. Under an idealized model, deflections are independent with probability 0.5 of moving right, implying a binomial distribution for the terminal bin location. Physical boards may deviate from this ideal due to asymmetries and other sources of bias. This thesis develops a Bayesian model for a 12-level Galton board in which each peg has its own right-move probability. Independent Beta priors are assigned to peg probabilities, and terminal bin counts …


Statistics 103a Instructor Guide, Elizabeth R. Wentworth Jan 2026

Statistics 103a Instructor Guide, Elizabeth R. Wentworth

Open Educational Resources

This set of slides contains reading, original videos, activities and instructions for instructors to run a complete 12 week course in any modality. These resources can be used to supplement in-person instruction or can be used for either a hybrid or asynchronous course.


Variational Autoencoder Inverse Mapper For Extraction Of Compton Form Factors: Benchmarks And Conditional Learning, Douglas Adams, Md Fayaz Bin Hossen, Joshua Bautista, Gia-Wei Chern, Simonetta Liuti, Marie Boër, Marija Čuić, Michael Engelhardt, Gary R. Goldstein, Huey-Wen Lin, Yaohang Li Jan 2026

Variational Autoencoder Inverse Mapper For Extraction Of Compton Form Factors: Benchmarks And Conditional Learning, Douglas Adams, Md Fayaz Bin Hossen, Joshua Bautista, Gia-Wei Chern, Simonetta Liuti, Marie Boër, Marija Čuić, Michael Engelhardt, Gary R. Goldstein, Huey-Wen Lin, Yaohang Li

Computer Science Faculty Publications

Deeply virtual exclusive scattering processes (DVES) serve as precise probes of nucleon quark and gluon distributions in coordinate space. These distributions are derived from generalized parton distributions (GPDs) via Fourier transform relative to proton momentum transfer. QCD factorization theorems enable DVES to be parameterized by Compton form factors (CFFs), which are convolutions of GPDs with perturbatively calculable kernels. Accurate extraction of CFFs from DVCS, benefiting from interference with the Bethe–Heitler (BH) process and a simpler final state structure, is essential for inferring GPDs. This paper focuses on extracting CFFs from DVCS data using a variational autoencoder inverse mapper (VAIM) and …


Cross-Temporal Statistical Approaches For Evaluating Predictor-Outcome Relationships, Jeff Joseph Jan 2026

Cross-Temporal Statistical Approaches For Evaluating Predictor-Outcome Relationships, Jeff Joseph

Dartmouth College Ph.D Dissertations

Central auditory function is linked with cognitive deficits, but few research projects use existing statistical approaches or develop new ones to forecast cognitive deficits using the results of central auditory tests. To address this limitation, we use a series of statistical learning frameworks for predicting a child’s cognitive abilities based on his/her central auditory performances and demographic factors. Two key challenges exist. First, children may start the study at a time when they are unable to perform the central auditory tests or cognitive tests. Second, cognitive performance is age-dependent, particularly in the early formative years of childhood and adolescence. To …


Exploring Marshall–Olkin Models Through Bibliometric And Topic Modeling Approaches Uses Latent Dirichlet Allocation (1981-2025): A Study Based On Scopus Data, Humberto Llinás, Brian Llinás, Carlos López, Daniela Nuñez Jan 2026

Exploring Marshall–Olkin Models Through Bibliometric And Topic Modeling Approaches Uses Latent Dirichlet Allocation (1981-2025): A Study Based On Scopus Data, Humberto Llinás, Brian Llinás, Carlos López, Daniela Nuñez

Computer Science Faculty Publications

The Marshall–Olkin family of distributions has gained increasing attention in fields such as reliability engineering, survival analysis, financial risk modeling, and actuarial science because of its flexibility in modeling dependence among events and its wide range of extensions. Despite its growing relevance, a systematic understanding of how research on Marshall–Olkin models has evolved over time is still limited. This study addresses this gap by combining bibliometric techniques with topic modeling to analyze the structure and evolution of the scientific literature on Marshall–Olkin models. The analysis includes all 266 peer-reviewed publications on Marshall–Olkin models indexed in Scopus between 1981 and 2025. …


Financial Literacy And Inclusion Of Philippine Jeepney And Tricycle Drivers, Bryan N. Bernabe, Jyro B. Triviño Jan 2026

Financial Literacy And Inclusion Of Philippine Jeepney And Tricycle Drivers, Bryan N. Bernabe, Jyro B. Triviño

Leadership and Strategy Faculty Publications

The study investigated how the different elements of financial literacy influence the financial inclusion of jeepney and tricycle drivers in Caloocan, Metro Manila. Pearson correlation analysis revealed a positive correlation between financial inclusion and attitude, behavior, knowledge, and skills. Additionally, analysis of variance highlighted that education and age play significant roles in enhancing financial literacy. The linear regression findings also supported the idea that income acts as a positive moderator, augmenting the impact of financial literacy on financial inclusion. The study attempted to disaggregate its financial literacy components to understand their impact on financial inclusion, but its interrelationships also require …


Machine Learning Prediction Of Federal Appellate Court Outcomes: A Multi-Circuit Analysis With Administrative Law Implications, Nicky Nuertey Apenahier Jan 2026

Machine Learning Prediction Of Federal Appellate Court Outcomes: A Multi-Circuit Analysis With Administrative Law Implications, Nicky Nuertey Apenahier

Dissertations and Theses

Federal appellate courts are the final arbiters in many cases, yet systematic machine learning analysis across all twelve circuits remains largely absent from the computational law literature. With courts of appeals deciding tens of thousands of cases annually and the Supreme Court reviewing only a fraction, understanding what predicts reversal outcomes has both theoretical importance and practical consequences for litigants, attorneys, and judicial administrators. This study addresses that gap using eleven years of federal appellate decisions from the Federal Judicial Center’s Integrated Database. A systematic comparison of twenty-five machine learning models, spanning five algorithms and five class-imbalance correction strategies, identifies …


Analyzing Sleep Architecture And Brain State Transitions Via Hidden Markov Models On Fmri Data, Brileigh Jay Cates Jan 2026

Analyzing Sleep Architecture And Brain State Transitions Via Hidden Markov Models On Fmri Data, Brileigh Jay Cates

Masters Theses

Sleep is associated with systematic changes in brain activity and functional connectivity observable in functional magnetic resonance imagining (fMRI) signals. Because subjects often fall asleep during resting-state experiments, the absence of vigilance monitoring can confound the interpretation of resting-state dynamics. Although electroencephalography (EEG) is the gold standard for sleep staging, simultaneous EEG-fMRI acquisition is not always feasible.

This study investigates whether sleep stages can be inferred directly from fMRI using a probabilistic latent-state framework. Hidden Markov Models (HMMs) are applied to blood-oxygen-level-dependent (BOLD) time series to identify latent brain states and their temporal transitions. Inferred states are aligned with EEG-derived …


Lessons Learned From Clinical Trials Of Thymic Stromal Lymphopoietin (Tslp) Inhibition, Jonathan Corren, Larry Borish, Christopher Brightling, Joseph K. Han, Emma Guttman-Yassky, Steven Ziegler, Jean Publicover, Jyotsna Gulati, Nestor Molfino, Christopher S. Ambrose, Jean-Pierre Llanos, Lang Chen, Jane R. Parnes, Joseph Spahn, Andrew Lindsley Jan 2026

Lessons Learned From Clinical Trials Of Thymic Stromal Lymphopoietin (Tslp) Inhibition, Jonathan Corren, Larry Borish, Christopher Brightling, Joseph K. Han, Emma Guttman-Yassky, Steven Ziegler, Jean Publicover, Jyotsna Gulati, Nestor Molfino, Christopher S. Ambrose, Jean-Pierre Llanos, Lang Chen, Jane R. Parnes, Joseph Spahn, Andrew Lindsley

Department of Otolaryngology (ENT) Faculty Publications

Type 2 (T2) immune–mediated epithelial-driven diseases are characterized by dysregulated immune responses at epithelial barrier surfaces. A key mediator of these diseases is thymic stromal lymphopoietin (TSLP), an epithelial cytokine that acts as a regulator of both T2 and non-T2 inflammation. TSLP activates dendritic cells and other immune cells, promoting the release of proinflammatory cytokines, including IL-4, IL-5, and IL-13. Given its central role in initiating and amplifying T2 inflammation, TSLP has emerged as a promising therapeutic target in multiple epithelial-driven inflammatory diseases. Tezepelumab is a human monoclonal antibody that selectively blocks TSLP from interacting with its receptor complex, thereby …


Defining Clinically Meaningful Within-Patient Changes In Heart Failure: Jacc Heart Failure Position Statement, Amin Yehya, Rebecca Hahn, Barry Borlaug, Victoria Delgado, Andrew Ambrosy, Ross Arena, Nosheen Reza, Gregory Lewis, Natalie Tapaskar, Salvatore Carbone, Cynthia Chauhan, Mitchell A. Psotka, Norman Stockbridge, James Januzzi, Javed Butler, Jennifer Cowger, Biykem Bozkurt, John Spertus Jan 2026

Defining Clinically Meaningful Within-Patient Changes In Heart Failure: Jacc Heart Failure Position Statement, Amin Yehya, Rebecca Hahn, Barry Borlaug, Victoria Delgado, Andrew Ambrosy, Ross Arena, Nosheen Reza, Gregory Lewis, Natalie Tapaskar, Salvatore Carbone, Cynthia Chauhan, Mitchell A. Psotka, Norman Stockbridge, James Januzzi, Javed Butler, Jennifer Cowger, Biykem Bozkurt, John Spertus

Department of Medicine Faculty Publications

Heart failure (HF) clinical trials increasingly rely on diverse endpoints beyond mortality, including hospitalizations, imaging, hemodynamic status, biomarkers, functional capacity, and patient-reported outcomes. Although statistically significant differences between treatment groups are commonly reported, interpreting whether these changes are clinically meaningful for individual patients remains challenging. This JACC: Heart Failure position statement proposes a pragmatic framework for defining clinically meaningful within-patient change across commonly used HF outcomes by integrating measurement variability, prognostic associations, and patient-anchored evidence where available. Relative and absolute risk reductions should both inform interpretation of clinical events, while imaging, hemodynamic, biomarker, and functional measures require changes exceeding measurement …


The Maxima Method For Identification Of Principal Periodic Components In Time Series Analysis, Megan Di Maio Jan 2026

The Maxima Method For Identification Of Principal Periodic Components In Time Series Analysis, Megan Di Maio

Electronic Theses & Dissertations (2024 - present)

This dissertation investigates methods for mean estimation in periodically correlated time series, focusing on the Variable Bandpass Periodic Block Bootstrap (VBPBB) and a novel data-driven maxima method. Time series require specific methods because of the temporal correlation in the data. Traditional methods like the General Seasonal Block Bootstrap (GSBB) account for this correlation but often produce wide confidence intervals because they cannot isolate multiple periodicities, allowing noise and other frequencies to interfere with analysis. The VBPBB method addresses this by applying a Kolmogorov-Zurbenko Fourier Transform (KZFT) filter to the data before bootstrapping, which suppresses interfering frequencies and results in narrower, …


First-Generation Medical School Applicants: A Quantitative Study Designed To Identify Areas Of Educational Support, Bethsabe Romero, Amanda K. Burbage Jan 2026

First-Generation Medical School Applicants: A Quantitative Study Designed To Identify Areas Of Educational Support, Bethsabe Romero, Amanda K. Burbage

EVMS School of Health Professions Faculty Publications

First-generation (First Gen) students are unique medical school applicants. Due to their lived experience, they approach patient care by prioritizing trust, comfort and understanding. They have proven ability to overcome obstacles and were found to be more resilient than their continuing generation (Cont Gen) peers. Despite these notable attributes, they face unique challenges in gaining medical school acceptance. There are very few quantitative studies examining this student subpopulation, and our study identifies characteristics of first-generation medical school applicants while highlighting areas of needed support. This cross-sectional study used deidentified Application and Matriculating Student Questionnaire survey data that was obtained from …


I Think, Therefore I Can: Self-Efficacy, Self-Regulation, And Sense Of Belonging In Introductory Physics, Danielle Christine Maldonado Jan 2026

I Think, Therefore I Can: Self-Efficacy, Self-Regulation, And Sense Of Belonging In Introductory Physics, Danielle Christine Maldonado

Graduate Theses, Dissertations, and Problem Reports (ETD)

Cognitive and affective beliefs in physics classrooms are important indicators of student success beyond traditional measurements of academic performance. This body of work explores major beliefs and processes, including self-efficacy, self-regulation, and sense of belonging, as they relate to academic achievement among introductory undergraduate physics students. First, this dissertation explores the development of physics self-efficacy and physics sense of belonging, two highly correlated variables. This work identifies unique sources of physics self-efficacy and sense of belonging development from current and prior academic experiences, personality factors, and demographic variables. Then, relationships between early- semester self-efficacy and sense of belonging, mid-semester …


Multiple Changepoint Detection For Non-Gaussian Time Series, Robert Lund, Thomas J. Fisher, Norou Diawara, Michael Wehner Jan 2026

Multiple Changepoint Detection For Non-Gaussian Time Series, Robert Lund, Thomas J. Fisher, Norou Diawara, Michael Wehner

Mathematics & Statistics Faculty Publications

This article combines methods from existing techniques to identify multiple changepoints in non‐Gaussian autocorrelated time series. A transformation is used to convert a Gaussian series into a non‐Gaussian series, enabling penalized likelihood methods to handle non‐Gaussian scenarios. When the marginal distribution of the data is continuous, the methods essentially reduce to the change of variables formula for probability densities. When the marginal distribution is count‐oriented, Hermite expansions and particle filtering techniques are used to quantify the scenario. Simulations demonstrating the efficacy of the methods are given and two data sets are analyzed: 1) the proportion of home runs hit by …


Flavor, Transverse Momentum, And Azimuthal Dependence Of Charged Pion Multiplicities In Semi-Inclusive Deep-Inelastic Scattering With 10.6 Gev Electrons, P. Bosted, H. Bhatt, S. Jia, W. Armstrong, D. Dutta, R. Ent, D. Gaskell, E. Kinney, H. Mkrtchyan, S. Ali, R. Ambrose, D. Androic, C. Ayerbe Gayoso, A. Bandari, V. Berdnikov, D. Bhetuwal, D. Biswas, M. Boer, E. Brash, A. Camsonne, M. Cardonna, J. P. Chen, J. Chen, M. Chen, E. M. Christy, S. Covrig, S. Danagoulian, M. Diefenthaler, B. Duran, C. Elliot, H. Fenker, E. Fuchey, J. O. Hansen, F. Hauenstein, T. Horn, G. M. Huber, M. K. Jones, M. L. Kabir, A. Karki, B. Karki, S. J. D. Kay, C. Keppel, V. Kumar, N. Lashley-Colthirst, W. B. Li, D. Mack, S. Malace, P. Markowitz, M. Mccaughan, E. Mcclellan, D. Meekins, R. Michaels, A. Mkrtchyan, C. Morean, G. Niculescu, I. Niculescu, B. Pandey, S. Park, E. Pooser, B. Sawatzky, G. R. Smith, H. Szumila-Vance, A. S. Tadepalli, V. Tadevosyan, R. Trotta, H. Voskanyan, S. A. Wood, Z. Ye, C. Yero, X. Zheng, Hall C Sidis Collaboration Jan 2026

Flavor, Transverse Momentum, And Azimuthal Dependence Of Charged Pion Multiplicities In Semi-Inclusive Deep-Inelastic Scattering With 10.6 Gev Electrons, P. Bosted, H. Bhatt, S. Jia, W. Armstrong, D. Dutta, R. Ent, D. Gaskell, E. Kinney, H. Mkrtchyan, S. Ali, R. Ambrose, D. Androic, C. Ayerbe Gayoso, A. Bandari, V. Berdnikov, D. Bhetuwal, D. Biswas, M. Boer, E. Brash, A. Camsonne, M. Cardonna, J. P. Chen, J. Chen, M. Chen, E. M. Christy, S. Covrig, S. Danagoulian, M. Diefenthaler, B. Duran, C. Elliot, H. Fenker, E. Fuchey, J. O. Hansen, F. Hauenstein, T. Horn, G. M. Huber, M. K. Jones, M. L. Kabir, A. Karki, B. Karki, S. J. D. Kay, C. Keppel, V. Kumar, N. Lashley-Colthirst, W. B. Li, D. Mack, S. Malace, P. Markowitz, M. Mccaughan, E. Mcclellan, D. Meekins, R. Michaels, A. Mkrtchyan, C. Morean, G. Niculescu, I. Niculescu, B. Pandey, S. Park, E. Pooser, B. Sawatzky, G. R. Smith, H. Szumila-Vance, A. S. Tadepalli, V. Tadevosyan, R. Trotta, H. Voskanyan, S. A. Wood, Z. Ye, C. Yero, X. Zheng, Hall C Sidis Collaboration

Physics Faculty Publications

Measurements of semi-inclusive deep-inelastic scattering multiplicities for 𝜋⁺ and 𝜋⁻ from proton and deuteron targets are reported on a grid of hadron kinematic variables 𝑧, 𝑃𝑇, and 𝜙* for leptonic kinematic variables in the range 0.3< 𝑥< 0.6 and 3< 𝑄²< 5GeV². Data were acquired in 2018 and 2019 at Jefferson Lab Hall C with a 10.6 GeV electron beam impinging on 10-cm-long liquid hydrogen and deuterium targets. Scattered electrons and charged pions were detected in the High Momentum Spectrometer and Super High Momentum Spectrometer, respectively. The multiplicities were fitted for each bin in (𝑥,𝑄²,𝑧,𝑃𝑡) to extract the 𝜙*—independent 𝑀₀ and the azimuthal modulations ⟨cos⁡(𝜙*)⟩ and ⟨cos⁡(2⁢𝜙*)⟩. The 𝑃𝑡 dependence of the 𝑀₀ results was found to be remarkably consistent for the four cases studied: 𝑒⁢𝑝→𝑒⁢𝜋+⁢𝑋, 𝑒⁢𝑝→𝑒⁢𝜋−⁢𝑋, 𝑒⁢𝑑→𝑒⁢𝜋+⁢𝑋, 𝑒⁢𝑑→𝑒⁢𝜋−⁢𝑋 over the range 0GeV< 𝑃𝑡< 0.4GeV, as were the multiplicities evaluated near 𝜙*=180∘ over the extended range 0GeV< 𝑃𝑡< 0.7GeV. The Gaussian widths of the 𝑃𝑡 dependence exhibit a quadratic increase with 𝑧. The cos⁡(𝜙*) modulations were found to be consistent with zero for 𝜋⁺, in agreement with previous world data, while the 𝜋− moments were, in many cases, significantly greater than zero. The cos⁡(2⁢𝜙*) modulations …


Assessing The Diversity And Composition Of Crayfish Assemblages In The Ogeechee River Basin, Reginald Turner Jan 2026

Assessing The Diversity And Composition Of Crayfish Assemblages In The Ogeechee River Basin, Reginald Turner

College of Graduate Studies: Theses & Dissertations

Crayfish assemblage composition in the southeastern United States is understudied relative to other aquatic taxa, such as aquatic insects and fishes, and the Coastal Plain watersheds of that region are particularly underrepresented in the contemporary literature on this topic. For example, although 38% of the crayfish species in Georgia are considered “species of greatest conservation need,” most of the distributional data used to make these designations are outdated, with some dating back over 50 years. This thesis sought to update our understanding of the contemporary distributions of crayfish species within the Ogeechee River Basin (ORB), a watershed in southeastern Georgia …


Swimming In Uncertainty: Filling Data Gaps And Providing An Educational Platform For Beach Water Quality At Tybee Island, Georgia, Lukas Roberson Jan 2026

Swimming In Uncertainty: Filling Data Gaps And Providing An Educational Platform For Beach Water Quality At Tybee Island, Georgia, Lukas Roberson

College of Graduate Studies: Theses & Dissertations

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Swimming in beaches water contaminated with high levels of bacteria can make you sick. Current monitoring at the public beaches on Tybee Island consists of weekly monitoring and enumeration of fecal indicator bacteria that takes 24 hours for results. If the number of bacteria exceed regulatory limits, a public health advisory is issued, and affected waters are retested until …


Factorial Design: A New Look Through Overlap Measures, Sarah W. Liebenow Jan 2026

Factorial Design: A New Look Through Overlap Measures, Sarah W. Liebenow

College of Graduate Studies: Theses & Dissertations

Traditional factorial analysis often relies on ANOVA, which assumes normality and equal variances. This thesis presents a nonparametric approach for assessing main and interaction effects in a 2 × 2 factorial design using the overlap coefficient, estimated through kernel density methods. A bootstrap procedure is used to approximate its sampling distribution for hypothesis testing. Simulation studies compare the overlap-based test with the ANOVA F-test, permutation F-test, and the Kruskal–Wallis test under heteroskedasticity and non-normal conditions. Results show that the overlap measure is highly sensitive to differences in spread and shape, detecting effects that traditional methods frequently miss.


Differential Impact Of Admission Type And Clinical Complexity On Diabetes Hospitalization Costs Among African American And Hispanic Patients In Southeastern Virginia, Ismail El Moudden, Asra Amidi, Reem Sharaf-Alddin, Michael C. Bittner, Qi Zhang Jan 2026

Differential Impact Of Admission Type And Clinical Complexity On Diabetes Hospitalization Costs Among African American And Hispanic Patients In Southeastern Virginia, Ismail El Moudden, Asra Amidi, Reem Sharaf-Alddin, Michael C. Bittner, Qi Zhang

Department of Obstetrics & Gynecology Faculty Publications

Background

Diabetes mellitus (DM) imposes substantial healthcare costs with documented disparities among African Americans and Hispanic patients. To inform care delivery and resource allocation, this study identified hospitalization cost predictors among African American and Hispanic patients with diabetes in Southeastern Virginia.

Methods

We analyzed 6,011 hospital discharges from the Virginia Health Information database (2016-2020) for adults aged 18-85 with diabetes. Discharges were classified by Medicare Severity Diagnosis-Related Groups: DM with complications/comorbidities (DCC, n = 3,328), DM with major complications/comorbidities (DMCC, n = 1,518), and DM without major complications/comorbidities (DWO, n = 1,165). Because cost distributions were right-skewed (skewness 3.5-8.24), we …


Modeling Healthcare Data With Logistic Quantile And Uniform-Based Mixture Polynomial Distributions, Mohan D. Pant, Aditya Chakraborty, Jovanna A. Tracz Jan 2026

Modeling Healthcare Data With Logistic Quantile And Uniform-Based Mixture Polynomial Distributions, Mohan D. Pant, Aditya Chakraborty, Jovanna A. Tracz

Epidemiology, Biostatistics, & Environmental Health Faculty Publications

Continuous healthcare data often deviate from normality, which can substantially increase the risk of making invalid inferences, given that many inferential statistical procedures rely on normality assumption. To obviate this issue, we propose a new family of non-normal distributions based on a linear combination of the quantile functions of standard logistic and uniform (0, 1) distributions. This new family of non-normal distributions is studied within three different methods: L-moments, conventional moments, and percentiles. Its performance is compared among the three methods in the context of parameter estimation and data modeling. The results of Monte Carlo simulation and bootstrapping techniques indicate …


Nirmatrelvir-Ritonavir Targeting Viral Persistence In Post-Covid-19 Condition (Long Covid) In The Usa (Recover-Vital): A Randomized, Double-Blind, Placebo Controlled, Phase 2 Trial, Lindsey R. Baden, Nirav S. Shah, Sean T. H. Liu, Jonathan Cohen, James May, Andre Kumar, Grace A. Mccomsey, Peter Chen, Michelle Floris-Moore, Nora G. Singer, Inti Fernandez, Alex J. Slandzicki, Zanthia Wiley, Alexandra Kadl, David A. Kaminsky, Harvey Hsu, Tiffany A. Walker, Aluko A. Hope, Luis Ostrosky-Zeichner, Jason D. Goldman, Michael J. Peluso, Thomas F. Patterson, Sairam Parthasarathy, Janet M. Mullington, Paul Bolin Jr., Sarah E. Jolley, Jerry A. Krishnan, Mario Castro, Sally L. Hodder, Priscilla Pemu, Helen Y. Chu, Michael G. Risbano, Maya R. Jerath, Eleftherios Mylonakis, Ryan T. Hurt, Radica Alicic, Nabila S. Azad, Marc A. Sala, Michelle S. Harkins, Jeffrey Parsonnet, Neil Stafford, Philip Robinson, Sabiha Hussain, Xian Qiao, Sophie Two Hawk, Michael Lillestol, Nathan Erdmann, Kelly A. Gebo, Praveen Sudhindra, Joseph Sassine, Gailen D. Marshall, Tulika Chatterjee, Caryn G. Morse, Eyal Kedar, William W. Stringer, Jennifer A. Frontera, Michael Jordon, Caitlin Blaskewicz, Jorge L. Santana, Rachel A. Foot, Cherry Wongtrakool, Matthew William Mccarthy, Alem Mehari, Arch Amon, Alison K. Cohen, Nita Jain, Christine Maughan, Doug Lindsay, Rachel Olson, Samuel Broderick, Pearl Rowe, Sean M. O'Brien, David R. Walt, Bruce D. Levy, Leonard A. Jason, Phillip A. Low, Cyndya A. Shibao, Barry Make, Lucinda Bateman, Susan Redline, David Knopman, Adrian F. Hernandez, Tracy L. Nolen, Craig Reist, Lisa Berdan, Richard Whitley, Kanecia O. Zimmerman, For The Recover-Vital Clinical Trial Group Jan 2026

Nirmatrelvir-Ritonavir Targeting Viral Persistence In Post-Covid-19 Condition (Long Covid) In The Usa (Recover-Vital): A Randomized, Double-Blind, Placebo Controlled, Phase 2 Trial, Lindsey R. Baden, Nirav S. Shah, Sean T. H. Liu, Jonathan Cohen, James May, Andre Kumar, Grace A. Mccomsey, Peter Chen, Michelle Floris-Moore, Nora G. Singer, Inti Fernandez, Alex J. Slandzicki, Zanthia Wiley, Alexandra Kadl, David A. Kaminsky, Harvey Hsu, Tiffany A. Walker, Aluko A. Hope, Luis Ostrosky-Zeichner, Jason D. Goldman, Michael J. Peluso, Thomas F. Patterson, Sairam Parthasarathy, Janet M. Mullington, Paul Bolin Jr., Sarah E. Jolley, Jerry A. Krishnan, Mario Castro, Sally L. Hodder, Priscilla Pemu, Helen Y. Chu, Michael G. Risbano, Maya R. Jerath, Eleftherios Mylonakis, Ryan T. Hurt, Radica Alicic, Nabila S. Azad, Marc A. Sala, Michelle S. Harkins, Jeffrey Parsonnet, Neil Stafford, Philip Robinson, Sabiha Hussain, Xian Qiao, Sophie Two Hawk, Michael Lillestol, Nathan Erdmann, Kelly A. Gebo, Praveen Sudhindra, Joseph Sassine, Gailen D. Marshall, Tulika Chatterjee, Caryn G. Morse, Eyal Kedar, William W. Stringer, Jennifer A. Frontera, Michael Jordon, Caitlin Blaskewicz, Jorge L. Santana, Rachel A. Foot, Cherry Wongtrakool, Matthew William Mccarthy, Alem Mehari, Arch Amon, Alison K. Cohen, Nita Jain, Christine Maughan, Doug Lindsay, Rachel Olson, Samuel Broderick, Pearl Rowe, Sean M. O'Brien, David R. Walt, Bruce D. Levy, Leonard A. Jason, Phillip A. Low, Cyndya A. Shibao, Barry Make, Lucinda Bateman, Susan Redline, David Knopman, Adrian F. Hernandez, Tracy L. Nolen, Craig Reist, Lisa Berdan, Richard Whitley, Kanecia O. Zimmerman, For The Recover-Vital Clinical Trial Group

Department of Medicine Faculty Publications

Background

Post-acute sequelae of SARS-CoV-2 infection, more commonly known as long COVID, has emerged as a major health problem. The pathogenesis of long COVID is unknown, but among the leading hypotheses is viral persistence. We aimed to investigate whether the use of the SARS-CoV-2 antiviral nirmatrelvir-ritonavir improved long COVID symptoms.

Methods

We conducted a double-blind, placebo-controlled, randomised trial involving adults who had developed persistent symptoms (≥12 weeks) associated with three major symptom phenotypes (cognitive, autonomic, or exercise) after acute SARS-CoV-2 infection at 69 US sites. Participants were eligible if they were 18 years or older and had a previous suspected, …


Essays On Accelerated Failure Time Models For Recurrent Event Data, Emmanuel Masavo Djegou Jan 2026

Essays On Accelerated Failure Time Models For Recurrent Event Data, Emmanuel Masavo Djegou

Doctoral Dissertations

Recurrent event data arise in many fields such as medicine, reliability, insurance, and economics, where the same event may occur repeatedly for a subject. Accelerated Failure Time (AFT) models provide an intuitive framework for relating covariates to event times and offer a useful alternative to proportional hazards models, allowing direct prediction of event timing under right censoring. However, existing AFT extensions for recurrent events, such as accelerated gap time (AGT) models, often fail to account for interventions between events and may not capture complex temporal patterns.

In this work, we first propose a class of semiparametric AGT models incorporating an …


Transformer-Based Language Models For Bitcoin Market Prediction And Interpretation, Erich Gozebina Jan 2026

Transformer-Based Language Models For Bitcoin Market Prediction And Interpretation, Erich Gozebina

Masters Theses

"In the context of a Master's thesis in applied mathematics, this work investigates compact transformer-based language models as an instrument for Bitcoin-related predictions and decision support. The work connects three topics: the structure of the Bitcoin system and its data, the mathematical and algorithmic foundations of deep autoregressive transformers, and the design of practical training pipelines for financial applications. On this foundation, a reproducible ETL pipeline for Bitcoin data is developed and two forecasting experiments are conducted with the compact language model nanochat. The first experiment approaches the prediction of next-day price movements through autoregressive next-token generation based on structured …


Traveling Waves For A Diffusive Sir Epidemic Model With Delay In The Diffusion Term, William Barker Jan 2026

Traveling Waves For A Diffusive Sir Epidemic Model With Delay In The Diffusion Term, William Barker

Faculty Scholarship

This paper investigates the existence of traveling waves in a diffusive SIR model with delay incorporated in the diffusion terms and a nonlinear incidence rate with delay. By employing a cross-iteration scheme and partial monotonicity conditions, we establish that the existence of quasi-upper and lower solutions, along with suitable super and sub-solutions, provides sufficient conditions for the existence of a traveling wavefront. This existence result is obtained via Schauder’s fixed-point theorem. Furthermore, given an appropriate basic reproduction number, the traveling wavefront transitions from the disease-free steady state to the endemic steady state. To illustrate our approach, we explicitly construct super- …


Understanding Motivations And Health Outcomes Of College-Aged Triathletes During Covid-19: A Mixed-Methods Study, Patrick Wilson, Eddie Hill, Justin Haegele, Xihe Zhu Jan 2026

Understanding Motivations And Health Outcomes Of College-Aged Triathletes During Covid-19: A Mixed-Methods Study, Patrick Wilson, Eddie Hill, Justin Haegele, Xihe Zhu

Human Movement Studies & Special Education Faculty Publications

A triathlon is a multi-sport event that consists of three simultaneous events: swimming, biking, and running. This sport has experienced significant growth in the past few decades, with colleges and universities now participating. This exploratory mixed-methods study examined the motivations and perceived health benefits of college triathletes during the COVID-19 pandemic, using the Means-Ends of Recreation Scale and the Perceived Health Outcomes of Recreation Scale (N = 29), as well as semi-structured interviews (N = 4). Results indicate no difference in motives or health outcomes between male and female survey respondents. The thematic analysis of open-ended interview questions highlighted lived …


Spectral Analysis Of Traffic Accidents In New York's Capital Region, Michael Barr Jan 2026

Spectral Analysis Of Traffic Accidents In New York's Capital Region, Michael Barr

Electronic Theses & Dissertations (2024 - present)

In this paper we estimate the spectral density of traffic accident events in the Capital Distict, NY area using a band-pass filter known as the Kolmogorov-Zurbenko Fourier Transform (KZFT). The source data is provided by Moosavi, et al. (2019) and originally captured from various public entities and sensors in the road network. Spectral density estimation with KZFT suppresses noise to reveal the constituent frequencies embedded in the noisy signal. Signal reconstruction based on KZFT produces an approximate weekly accident arrivals for this noisy signal, or in other words a pattern which is proportionate to the event expectation viewed over a …