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Causal Inference Using Bayesian Network For Search And Rescue, Amanda Belden Jun 2024

Causal Inference Using Bayesian Network For Search And Rescue, Amanda Belden

Master's Theses

People who are considered missing have much higher probabilities of being found dead compared to those who are not considered missing in terms of Search and Rescue (SAR) missions. Dementia patients are incredibly likely to be declared missing, and in fact after removing those with dementia the probability of the mission being regarded as missing person case is only about 10%. Additionally, those who go missing are much more likely to be on private land than on protected areas such as forests and parks. These and similar associations can be represented and investigated using a Bayesian network that has been …


An Experimental Study Of Supervised Machine Learning Techniques For Minor Class Prediction Utilizing Kernel Density Estimation: Factors Impacting Model Performance, Abdullah Mana Alfarwan Jun 2024

An Experimental Study Of Supervised Machine Learning Techniques For Minor Class Prediction Utilizing Kernel Density Estimation: Factors Impacting Model Performance, Abdullah Mana Alfarwan

Dissertations

This dissertation examined classification outcome differences among four popular individual supervised machine learning (ISML) models (logistic regression, decision tree, support vector machine, and multilayer perceptron) when predicting minor class membership within imbalanced datasets. The study context and the theoretical population sampled focus on one aspect of the larger problem of student retention and dropout prediction in higher education (HE): identification.

This study differs from current literature by implementing an experimental design approach with simulated student data that closely mirrors HE situational and student data. Specifically, this study tested the predictive ability of the four ISML classification models (CLS) under experimentally …


Alternative Adjacency Matrices And Spatial Analysis, Jaeseong Hwang Jun 2024

Alternative Adjacency Matrices And Spatial Analysis, Jaeseong Hwang

Dissertations

Spatial analysis is essential for comprehending the spatial distribution of diseases and various phenomena across geographic regions. This study investigates the utilization of alternative adjacency matrices in spatial analysis, with a specific focus on implementing Poisson regression models. This study intricately explores the methodology behind constructing alternative weight matrices, specifying weight matrices, and comparing the performance of Poisson models using five different weight matrices.

The popular Poisson model model is described, and five different definitions of weight matrices are defined, which are the following: binary weight matrix, inverse distance weight matrix using Euclidean distance, Graph distance matrix, Path matrix, and …


Snpaimer: R Package For Evaluating Ancestry Informative Marker Contributions In Non-Model Population Diagnostics, Kim L. Vertacnik, Oksana V. Vernygora, Julian R. Dupuis Jun 2024

Snpaimer: R Package For Evaluating Ancestry Informative Marker Contributions In Non-Model Population Diagnostics, Kim L. Vertacnik, Oksana V. Vernygora, Julian R. Dupuis

Entomology Faculty Publications

Motivation: Single nucleotide polymorphism (SNP) markers are increasingly popular for population genomics and inferring ancestry for individuals of unknown origin. Because large SNP datasets are impractical for rapid and routine analysis, diagnostics rely on panels of highly informative markers. Strategies exist for selecting these markers, however, resources for efficiently evaluating their performance are limited for non-model systems.

Results: snpAIMeR is a user-friendly R package that evaluates the efficacy of genomic markers for the cluster assignment of unknown individuals. It is intended to help minimize panel size and genotyping effort by determining the informativeness of candidate diagnostic markers. Provided genotype data …


(R2073) Analysis Of Mmap/Ph(1), Ph(2)/1 Preemptive Priority Queueing Model With Single Vacation, Repair And Impatient Customers, S. Meena, G. Ayyappan Jun 2024

(R2073) Analysis Of Mmap/Ph(1), Ph(2)/1 Preemptive Priority Queueing Model With Single Vacation, Repair And Impatient Customers, S. Meena, G. Ayyappan

Applications and Applied Mathematics: An International Journal (AAM)

In this paper, we analyse a single server preemptive priority queue with phase-type vacation and repair, feedback, working breakdown, close-down and impatient customers. Customers arrive according to the Marked Markovian Arrival Process and their service time according to Phase-type distribution. If the High Priority customers need feedback, they lose their priority and join the Low Priority queue. At any instant, if the server is broken down, the server provide service with slow mode for that current customer and then the server will go into a repair process. When there are no customers present in both the queues, the server close-down …


Value Added Tax Rate Variation, Import Demand And Sectoral Output In Nigeria, Joshua K. Nomkuha, Aondoawase Asooso, Philip T. Abachi Jun 2024

Value Added Tax Rate Variation, Import Demand And Sectoral Output In Nigeria, Joshua K. Nomkuha, Aondoawase Asooso, Philip T. Abachi

CBN Journal of Applied Statistics (JAS)

This study employs computable general equilibrium (CGE) model to estimate the effect of increase in value added tax (VAT), from 5 per cent to 7.5 per cent, on import demand and sectoral output in Nigeria. The study uses 2020 as the base year for the data analysis. The results show that increase in VAT affects import demand negatively, based on import penetration ratios, with mixed effect across six sectors. The implication of the result is that the VAT policy discourage consumption of foreign products, and constitute excess burden to consumers of such products in Nigeria. The results further reveal that …


Trade Liberalization, Non-Oil Export And Economic Growth In Nigeria, Jerome T. Andohol, Terhemen Tarzoor, Dennis T. Nomor Jun 2024

Trade Liberalization, Non-Oil Export And Economic Growth In Nigeria, Jerome T. Andohol, Terhemen Tarzoor, Dennis T. Nomor

CBN Journal of Applied Statistics (JAS)

The study examines the impact of trade liberalization and non-oil exports on economic growth in Nigeria from 1986 to 2021. The study utilizes an autoregressive distributed lag model and found the combined effect of trade liberalization and non-oil exports to be positive and statistical significant. While trade liberalization alone may have negative consequences, its synergy with a robust non-oil export can drive sustainable economic growth. The study recommends that strategies to enhance non-oil exports should be encouraged to support the effectiveness of trade liberalization in promoting growth.


The Effectiveness Of Monetary Policy Transmission In Nigeria: Evidence From The Monetary Policy Rate And The Cash Reserve Ratio, Abdulrahman A. Nadani, Auwal Isah Jun 2024

The Effectiveness Of Monetary Policy Transmission In Nigeria: Evidence From The Monetary Policy Rate And The Cash Reserve Ratio, Abdulrahman A. Nadani, Auwal Isah

CBN Journal of Applied Statistics (JAS)

This paper investigates the effectiveness of the Monetary Policy Rate (MPR) and Cash Reserve Ratio (CRR) as policy instruments in Nigeria. A structural VAR model is employed to simulate two distinct models measuring shocks from the MPR and the CRR using monthly data from January 2006 to December 2023. Findings show that contractionary monetary policy impulses using MPR and the CRR contract output and credit to the private sector, inflation remains largely positive in the two models, known as the “price puzzle”, but the puzzle is more persistent in the MPR equation. Moreover, shock to MPR strongly influences short-term interest …


Stock Market Volatility In The United Kingdom: Simulating Post-Covid-19 Recovery, Bala A. Dahiru, Mohammed Shuaibu, Najibullah Hassanov Jun 2024

Stock Market Volatility In The United Kingdom: Simulating Post-Covid-19 Recovery, Bala A. Dahiru, Mohammed Shuaibu, Najibullah Hassanov

CBN Journal of Applied Statistics (JAS)

This paper investigates the time it would take for the FTSE-100 index to reach its post-COVID-19 peak. The paper utilises an exponential generalised autoregressive conditional heteroscedasticity (EGARCH) model that accounts for leverage effect and asymmetries. The preferred models amongst competing variants was the Autoregressive Moving Average (ARMA)-EGARCH(2,1) specification and was used to predict daily FTSE-100 data from 5th January 2000 to 21st June 2024. The empirical exercise showed that the COVID-19-induced financial crisis negatively affected the United Kingdom’s stock market performance. The results show that the FTSE100 index could reach its post-pandemic peak around 27th August, 2024 (two months after …


Impact Of Fiscal Policy On Financial Inclusion And Development In Nigeria, Okwanya Innocent, Taiwo A. Olusegun, Aimua E. Peace Jun 2024

Impact Of Fiscal Policy On Financial Inclusion And Development In Nigeria, Okwanya Innocent, Taiwo A. Olusegun, Aimua E. Peace

CBN Journal of Applied Statistics (JAS)

This paper examines the effect of fiscal policy on financial inclusion and development in Nigeria. The study employs the Autoregressive Distributed Lag (ARDL) model and impulse response function (IRF) to determine the extent and response of financial inclusion and development to fiscal policy changes in Nigeria. The study derives a financial inclusion index from three core indicators: access, usage and quality of financial services, while financial development is measured as the ratio of money supply to GDP (M2/GDP). The results show that government expenditure has a significant positive effect on financial inclusion and development, while tax revenue exerts a negative …


Qwixx Strategies Using Simulation And Mcmc Methods, Joshua W. Blank Jun 2024

Qwixx Strategies Using Simulation And Mcmc Methods, Joshua W. Blank

Master's Theses

This study explores optimal strategies for maximizing scores and winning in the popular dice game Qwixx, analyzing both single and multiplayer gameplay scenarios. Through extensive simulations, various strategies were tested and compared, including a scorebased approach that uses a formula tuned by MCMC random walks, and race-to-lock approaches which use absorbing Markov chain qualities of individual score sheet rows to find ways to lock rows as quickly as possible. Results indicate that employing a scorebased strategy, considering gap, count, position, skip, and likelihood scores, significantly improves performance in single player games, while move restrictions based on specific dice roll sums …


The Impact Of Video Assistant Referee (Var) On The English Premier League, Jack Kenyon Brown Jun 2024

The Impact Of Video Assistant Referee (Var) On The English Premier League, Jack Kenyon Brown

Master's Theses

The aim of this study is to examine how the introduction of the Video Assisted Referee (VAR) system influenced the English Premier League (EPL). Since its implementation in the English Premier League in 2019, VAR has been a constant source of debate and controversy. Many studies have been done on the immediate impact of VAR on other elite professional soccer leagues, but the scope of results is very limited and due to be updated. The data for the ensuing analysis consists of 3800 matches played in the English Premier League during the five seasons before (14/15, 15/16, 16/17, 17/18, and …


Recursive Marix Game Analysis: Optimal, Simplified, And Human Strategies In Brave Rats, William A. Medwid Jun 2024

Recursive Marix Game Analysis: Optimal, Simplified, And Human Strategies In Brave Rats, William A. Medwid

Master's Theses

Brave Rats is a short game with simple rules, yet establishing a comprehensive strategy is very challenging without extensive computation. After explaining the rules, this paper begins by calculating the optimal strategy by recursively solving each turn’s Minimax strategy. It then provides summary statistics about the complex, branching Minimax solution. Next, we examine six other strategy models and evaluate their performance against each other. These models’ flaws highlight the key elements that contribute to the effectiveness of the Minimax strategy and offer insight into simpler strategies that human players could mimic. Finally, we analyze 123 games of human data collected …


Unraveling The History Of Deforestation In The Amazon Rainforest With Statistical Modeling, Ryan Destefano Jun 2024

Unraveling The History Of Deforestation In The Amazon Rainforest With Statistical Modeling, Ryan Destefano

Master's Theses

The Amazon rainforest, a vital ecosystem of immense biodiversity and global climate significance, faces the ongoing threat of deforestation driven by agricultural expansion. This thesis employs remote sensing techniques, focusing on the Enhanced Vegetation Index (EVI) derived from Landsat satellite imagery, to track land cover dynamics within the Amazon. The study examines historical land cover changes in current plantations in Peru and Brazil, regions where the exact timing of deforestation is uncertain. By analyzing EVI measurements dating back to 1984, inflection points indicative of deforestation events preceding plantation establishment are identified. Statistical modeling techniques, including spline fitting to analyze time …


Using Plankton Edna To Estimate Whale Abundances Off The California Coast: Data Integration And Statistical Modeling, Katherine Chan Jun 2024

Using Plankton Edna To Estimate Whale Abundances Off The California Coast: Data Integration And Statistical Modeling, Katherine Chan

Master's Theses

Understanding marine mammal populations and how they are affected by human activity and ocean conditions is vital, especially in tracking population declines and monitoring endangered species. However, tracking marine mammal populations and their distribution is challenging due to difficulties in observation and costs. Using surrounding plankton environmental DNA (eDNA) has the potential to provide an indirect measure of monitoring cetacean abundances based on ecological associations. This project aims to apply statistical methods to assess the relationship of visual abundances of common species of baleen whales with amplicon sequence variants (ASV) of plankton eDNA samples from the NOAA-CalCOFI Ocean Genomics (NCOG) …


Physician-Patient Interactions In Online Healthcare Communities: The Effects Of Preconsultation On Service Delivery And Patient Satisfaction, Qian Tang, Anqi Zhao Jun 2024

Physician-Patient Interactions In Online Healthcare Communities: The Effects Of Preconsultation On Service Delivery And Patient Satisfaction, Qian Tang, Anqi Zhao

Research Collection School Of Computing and Information Systems

Preconsultation by medical professionals is a common practice in offline healthcare services to improve consultation efficiency but is rarely adopted for online healthcare services. In a noteworthy departure from this trend, a Chinese online healthcare community (OHC) has instituted preconsultation by assistant physicians prior to online consultations. Using comprehensive service data from this OHC, this study scrutinizes the effects of preconsultation on online healthcare services from both the physician and patient perspectives. The findings reveal that preconsultation by the assistant physician can significantly increase the attending physician’s response speed, length, and provision of informational support, while maintaining a consistent level …


Morphometric Analysis And Taxonomic Re-Evaluation Of Pepsis Cerberus Lucas And P. Elegans Lepeletier (Hymenoptera: Pompilidae: Pepsinae: Pepsini), Frank E. Kurczewski, Akira Shimizu, Diane H. Kiernan May 2024

Morphometric Analysis And Taxonomic Re-Evaluation Of Pepsis Cerberus Lucas And P. Elegans Lepeletier (Hymenoptera: Pompilidae: Pepsinae: Pepsini), Frank E. Kurczewski, Akira Shimizu, Diane H. Kiernan

Insecta Mundi

Hurd (1952) separated Pepsis cerberus Lucas from P. elegans Lepeletier (Hymenoptera: Pompilidae: Pepsinae: Pepsini) based on external morphology and biogeography. Vardy (2005) synonymized the familiar and historically well-documented P. cerberus and P. elegans, combining these Nearctic taxa with several Neotropical variants in an extremely broad definition of P. menechma Lepeletier. In doing so, Vardy (2005) breached the principle of nomenclatural stability. He ignored the prevailing usage and clearly violated articles 23.2, 23.3 and 23.9.1.2 of the ICZN (1999). Morphological differences, ecological divergence, and narrow sympatric geographic distribution of P. cerberus and P. elegans …


A Comparisons Of The Covariate Types In Applications Of Semtree Model To Educational Studies, Minju Hong, Juyeon Lee May 2024

A Comparisons Of The Covariate Types In Applications Of Semtree Model To Educational Studies, Minju Hong, Juyeon Lee

Counseling, Leadership, and Research Methods Faculty Publications and Presentations

In this study, we investigated the applicability of the SEMtree model to analyze the longitudinal data analysis in educational studies. SEMtree is one of the advanced approaches to incorporate the advantages of structural equation modeling and decision tree models under confirmatory and exploratory data analysis frameworks. The main purpose of this study is to figure out how the researcher deals with the data conditions of covariates when using the SEMtree model. By analyzing KCYPS 2018 the 4th-grade elementary school students' panel, we found that there were differences of the duplicated selected covariates when splitting the nodes in the SEMtree model …


Spatial Durbin Model On The Utilization Of Delivery At Health Facilities: A 2017 Indonesian Demographic And Health Survey Analysis, Indah Sri Wahyuni, Ira Gustina, Martya Rahmaniati Makful, Tris Eryando May 2024

Spatial Durbin Model On The Utilization Of Delivery At Health Facilities: A 2017 Indonesian Demographic And Health Survey Analysis, Indah Sri Wahyuni, Ira Gustina, Martya Rahmaniati Makful, Tris Eryando

Kesmas

The utilization of delivery at health facilities is a major intervention in reducing 16 to 33% of deaths. This study aimed to determine the model of utilization of delivery at health facilities in Indonesia in 2017 and its influential factors. This study used secondary data from the 2017 Indonesian Demographic and Health Survey using a Spatial Durbin Model (SDM) approach. The population was mothers aged 15 – 49 years, spread across 34 provinces of Indonesia, and had 15,321 samples. The results showed that the Moran’s I value was positive (0.146) and significant at p-value = 0.007, indicating clustered regions with …


Mapping For Tracking Sexually Transmitted Infections By Subdistricts In Surabaya, Indonesia, Destri Susilaningrum, Brodjol Sutijo Suprih Ulama, Fausania Hibatullah, Diandra Soja Anjani May 2024

Mapping For Tracking Sexually Transmitted Infections By Subdistricts In Surabaya, Indonesia, Destri Susilaningrum, Brodjol Sutijo Suprih Ulama, Fausania Hibatullah, Diandra Soja Anjani

Kesmas

The 2014 shutdown localization of prostitution in Surabaya City, East Java Province, Indonesia, has given rise to an illegal prostitution industry, resulting in the spread of uncontrolled sexually transmitted infections (STIs). Mapping needs to be done to track the spread of the disease. This study used secondary data on STIs in 2020 from the Surabaya City Health Office. By using biplot analysis, this study sought to offer a detailed understanding of the distribution and dynamics of STI cases in different parts of Surabaya. The early-stage syphilis was found in Tegalsari and Krembangan Subdistricts; then, gonorrheal urethritis was found in Tandes, …


A Symbolic Approach To Nonlinear Time Series Analysis, Ranjan Karki, Nibhrat Lohia, Michael B. Schulte May 2024

A Symbolic Approach To Nonlinear Time Series Analysis, Ranjan Karki, Nibhrat Lohia, Michael B. Schulte

SMU Data Science Review

Current nonlinear time series methods such as neural networks forecast well. However, they act as a black box and are difficult to interpret, leaving the researchers and the audience with little insight into why the forecasts are the way they are. There is a need for a method that forecasts accurately while also being easy to interpret. This paper aims to develop a method to build an interpretable model for univariate and multivariate nonlinear time series data using wavelets and symbolic regression. The final method relies on multilayer perceptron (MLP) neural networks as a form of dimensionality reduction and the …


Reevaluating Texas Energy Market Forecasts In The Wake Of Recent Extreme Weather Events, Robert A. Derner, Richard W. Butler Ii, Alexandria Neff, Adam R. Ruthford May 2024

Reevaluating Texas Energy Market Forecasts In The Wake Of Recent Extreme Weather Events, Robert A. Derner, Richard W. Butler Ii, Alexandria Neff, Adam R. Ruthford

SMU Data Science Review

This paper provides updated forecasts of energy demand in Texas and recognizes the impact of sustainable energy. It is important that the forecasts of the adoption of sustainable energy are reexamined after Winter Storm Uri crippled the Texas power grid and left many without power. This storm highlighted the issues the Texas power grid had and has continued to struggle with in supplying the state with energy. This paper will offer an overview of the relevant literature on the adoption of sustainable energy and relevant events that have occurred in the state of Texas that will give the reader the …


Leveraging Transformer Models For Genre Classification, Andreea C. Craus, Ben Berger, Yves Hughes, Hayley Horn May 2024

Leveraging Transformer Models For Genre Classification, Andreea C. Craus, Ben Berger, Yves Hughes, Hayley Horn

SMU Data Science Review

As the digital music landscape continues to expand, the need for effective methods to understand and contextualize the diverse genres of lyrical content becomes increasingly critical. This research focuses on the application of transformer models in the domain of music analysis, specifically in the task of lyric genre classification. By leveraging the advanced capabilities of transformer architectures, this project aims to capture intricate linguistic nuances within song lyrics, thereby enhancing the accuracy and efficiency of genre classification. The relevance of this project lies in its potential to contribute to the development of automated systems for music recommendation and genre-based playlist …


Advancing Objective Mobile Device Use Measurement Inchildren Ages 6–11 Through Built-In Device Sensors: A Proof-Of-Concept Study, Olivia L. Finnegan, Robert Glenn Weaver Med, Phd, Hongpeng Yang, James W. White, Srihari Nelakuditi, Zifei Zhong, Rahul Ghosal Ph.D., Yan Tong, Aliye B. Cepni, Elizabeth L. Adams, Sarah Burkart Mph, Ph.D., Michael W. Beets Med, Mph, Phd, Bridget Armstrong Ph.D. May 2024

Advancing Objective Mobile Device Use Measurement Inchildren Ages 6–11 Through Built-In Device Sensors: A Proof-Of-Concept Study, Olivia L. Finnegan, Robert Glenn Weaver Med, Phd, Hongpeng Yang, James W. White, Srihari Nelakuditi, Zifei Zhong, Rahul Ghosal Ph.D., Yan Tong, Aliye B. Cepni, Elizabeth L. Adams, Sarah Burkart Mph, Ph.D., Michael W. Beets Med, Mph, Phd, Bridget Armstrong Ph.D.

Faculty Publications

Mobile devices (e.g., tablets and smartphones) have been rapidly integrated into the lives of children and have impacted howchildren engage with digital media. The portability of these devices allows for sporadic, on-demand interaction, reducing theaccuracy of self-report estimates of mobile device use. Passive sensing applications objectively monitor time spent on a givendevice but are unable to identify who is using the device, a significant limitation in child screen time research. Behavioralbiometric authentication, using embedded mobile device sensors to continuously authenticate users, could be applied toaddress this limitation. This study examined the preliminary accuracy of machine learning models trained on iPad …


Bagging Improves The Performance Of Deep Learning-Based Semantic Segmentation With Limited Labeled Images: A Case Study Of Crop Segmentation For High-Throughput Plant Phenotyping, Yinglun Zhan, Yuzhen Zhou, Geng Bai, Yufeng Ge May 2024

Bagging Improves The Performance Of Deep Learning-Based Semantic Segmentation With Limited Labeled Images: A Case Study Of Crop Segmentation For High-Throughput Plant Phenotyping, Yinglun Zhan, Yuzhen Zhou, Geng Bai, Yufeng Ge

Department of Statistics: Faculty Publications

Advancements in imaging, computer vision, and automation have revolutionized various fields, including field-based high-throughput plant phenotyping (FHTPP). This integration allows for the rapid and accurate measurement of plant traits. Deep Convolutional Neural Networks (DCNNs) have emerged as a powerful tool in FHTPP, particularly in crop segmentation—identifying crops from the background—crucial for trait analysis. However, the effectiveness of DCNNs often hinges on the availability of large, labeled datasets, which poses a challenge due to the high cost of labeling. In this study, a deep learning with bagging approach is introduced to enhance crop segmentation using high-resolution RGB images, tested on the …


Reports Of Autosomal Recessive Disease And Consanguineous Mating Within The Human Population, Johnathon L. Schluter May 2024

Reports Of Autosomal Recessive Disease And Consanguineous Mating Within The Human Population, Johnathon L. Schluter

Master's Theses

It is anecdotally evident when investigating published reports of autosomal recessive disease that a substantial number of cases are the result of related (consanguineous) mating. This research seeks to quantify the percent of manuscripts describing autosomal recessive diseases published between 2000 and 2020 in which consanguineous mating is indicated. We analyzed 602 peer-reviewed manuscripts to identify the percentage of cases presented in which consanguineous mating was indicated, the underlying genes (novel gene or new mutation) and geographical region. These papers were accessed through a specific set of parameters on the free access PubMed Central (PMC) database. A total of 552 …


Context Aware Music Recommendation And Playlist Generation, Elias Mann May 2024

Context Aware Music Recommendation And Playlist Generation, Elias Mann

SMU Journal of Undergraduate Research

There are many reasons people listen to music, and the type of music is largely determined by what the listener may be doing while they listen. For example, one may listen to one type of music while commuting, another while exercising, and yet another while relaxing. Without access to the physiological state of the user, current music recommendation methods rely on collaborative filtering - recommending music based on what other similar users listen to - and content based filtering - recommending songs based on their similarities to songs the user already prefers. With the rise in popularity of smart devices …


Perspective—Surface-Display Techniques In Electrochemical Biosensor Designs For Health Monitoring, Courtney J. Weber, Megan D. Whisonant, Olivia M. Clay, Olja Simoska May 2024

Perspective—Surface-Display Techniques In Electrochemical Biosensor Designs For Health Monitoring, Courtney J. Weber, Megan D. Whisonant, Olivia M. Clay, Olja Simoska

Faculty Publications

Enzymatic and microbial electrochemical biosensors integrate enzymes and microorganisms as biological recognition elements into the sensor design and functionality. Enzyme-based sensors offer high sensitivity and selectivity for target analyte detection. However, these have limited stability necessary for continuous analyte monitoring. Contrarily, microbe-based electrochemical sensors provide a means for continuous analyte sensing but are associated with challenges related to analyte selectivity in complex samples. To address these limitations, surface-display methods, which bind enzymes to microbial surfaces, enhance biosensor selectivity and sensitivity. This perspective outlines the application of surface-display techniques, offering a promising avenue for health monitoring.


Employing Digital Pcr For Enhanced Detection Of Perinatal Toxoplasma Gondii Infection: A Cross-Sectional Surveillance And Maternal-Infant Outcomes Study In El Salvador, Mary K. Lynn, Marvin Stanley Rodriguez Aquino, Pamela Michelle Cornejo Rivas, Xiomara Miranda, David F. Torres-Romero, Hanson Cowan, Madeleine M. Meyer, Willber D. Castro-Godoy, Mufaro Kanyangarara Ph.D., Stella Coker Watson Self Ph.D., Ms, Berry A. Campbell, Melissa Nolan Ph.D., Mph May 2024

Employing Digital Pcr For Enhanced Detection Of Perinatal Toxoplasma Gondii Infection: A Cross-Sectional Surveillance And Maternal-Infant Outcomes Study In El Salvador, Mary K. Lynn, Marvin Stanley Rodriguez Aquino, Pamela Michelle Cornejo Rivas, Xiomara Miranda, David F. Torres-Romero, Hanson Cowan, Madeleine M. Meyer, Willber D. Castro-Godoy, Mufaro Kanyangarara Ph.D., Stella Coker Watson Self Ph.D., Ms, Berry A. Campbell, Melissa Nolan Ph.D., Mph

Faculty Publications

Toxoplasma gondii is a parasitic infection that can be transmitted in utero, resulting in fetal chorioretinitis and other long-term neurological outcomes. If diagnosed early, pregnancy-safe chemotherapeutics can prevent vertical transmission. Unfortunately, diagnosis of acute, primary infection among pregnant women remains neglected, particularly in low-and-middle-income countries. Clinically actionable diagnosis is complex due to the commonality of infection during childhood and early adulthood which spawn long-last antibody titers and historically unreliable direct molecular diagnostics. The current study employed a cross-sectional T. gondii perinatal surveillance study using digital PCR, a next generation molecular diagnostic platform, and a maternal-fetal outcomes survey to ascertain …


Towards A New Role Of Mitochondrial Hydrogen Peroxide In Synaptic Function, Cliyahnelle Z. Alexander May 2024

Towards A New Role Of Mitochondrial Hydrogen Peroxide In Synaptic Function, Cliyahnelle Z. Alexander

Student Theses and Dissertations

Aerobic metabolism is known to generate damaging ROS, particularly hydrogen peroxide. Reactive oxygen species (ROS) are highly reactive molecules containing oxygen that have the potential to cause damage to cells and tissues in the body. ROS are highly reactive atoms or molecules that rapidly interact with other molecules within a cell. Intracellular accumulation can result in oxidative damage, dysfunction, and cell death. Due to the limitations of H2O2 (hydrogen peroxide) detectors, other impacts of ROS exposure may have been missed. HyPer7, a genetically encoded sensor, measures hydrogen peroxide emissions precisely and sensitively, even at sublethal levels, during …