Digital Commons Network^™

Research On The Status Quo And Operational Modes Of Chinese Petrochemical Logistics, Jiajie Hou

World Maritime University Dissertations

No abstract provided.

Research On Competitiveness Of Dalian Port, Zhaobo Xu

World Maritime University Dissertations

No abstract provided.

Study On Modern Port Logistics (Mpl) And Forecasting Container Throughput Of Shanghai Port, Jingye Li

World Maritime University Dissertations

No abstract provided.

Study On Grade Evaluation Of Port Shoreline In Jiangsu Province, Wei Li

World Maritime University Dissertations

No abstract provided.

Analysis Of Shanghai Port's Competitiveness After The Operation Of Yangshan Deep-Water Port, Wei Jiang

World Maritime University Dissertations

No abstract provided.

The Study On Sinochem Shipping Corporation’S Fleet Expansion, Yunhao Ji

World Maritime University Dissertations

No abstract provided.

Research Of Be550 Rigs Transportation Projects, Lifeng Shi

World Maritime University Dissertations

No abstract provided.

The Logistics Supplier Selection Of Sgm With Ahp Method, Jian Wang

World Maritime University Dissertations

No abstract provided.

Choice And Optimization Of Forecasting Models For Container Port Throughput, Qingcheng Xue

World Maritime University Dissertations

No abstract provided.

Predictors Of Emotional Reactions In Women Treated For Breast Cancer, Erin E. Ramirez

Loma Linda University Electronic Theses, Dissertations & Projects

Breast cancer can be a devastating disease that impacts a woman in all spheres of her life (Ingram, 1989). Previous studies have examined the impact of breast cancer on body satisfaction, as well as the impact on emotional well-being. Studies have also examined the role of the coping style that a woman engages in response to the diagnosis and treatment of breast cancer in the woman's psychological adjustment to the disease. However, to date, no research has introduced and tested a multifaceted model.

The purpose of this study was to develop a model predicting psychological maladjustment in women treated for …

Decompositions Of Signed-Graphic Matroids, Dan Slilaty, Hongxun Qin

Mathematics and Statistics Faculty Publications

We give a decomposition theorem for signed graphs whose frame matroids are binary and a decomposition theorem for signed graphs whose frame matroids are quaternary.

Predictors Of Female Sexual Dysfunction, Julie M. Merrell

Loma Linda University Electronic Theses, Dissertations & Projects

Tiefer, Hall, and Tavris (2002) described factors comprising four categories of female sexual dysfunction. They suggested that unique factors need to be examined to understand sexual dysfunction in women. Socio-cultural, political, or economic factors, partner and relationship factors, psychological factors, and medical factors described as aspects of women’s lives that can be the source of sexual dysfunction. The current study examined indicators of the above factors-body shame, relationship satisfaction, sexual self-schema, positive and negative affect, and overall health-as predictors of female sexual dysfunction. The hypotheses were: Body shame and negative affect will be negatively associated with sexual function; and relationship …

A Censored Multinomial Regression Model For Perinatal Mother To Child Transmission Of Hiv, Charlotte C. Gard, Elizabeth R. Brown

UW Biostatistics Working Paper Series

In studies designed to estimate rates of perinatal mother to child transmission of HIV, HIV assays are scheduled at multiple points in time. Still infection status for some infants at some time points is often unknown, particularly when interim analyses are conducted. Logistic regression and Cox proportional hazards regression are commonly used to estimate covariate-adjusted transmission rates, but their methods for handling missing data may be inadequate. Here, we propose using censored multinomial regression models to estimate cumulative and conditional rates of HIV transmission. Through simulation, we show that the proposed methods perform better than standard logistic models in terms …

An Example Of How To Write The Statistical Section Of A Bioequivalence Study Protocol For Fda Review, William F. Mccarthy

COBRA Preprint Series

This paper provides a detailed example of how one should write the statistical section of a bioequivalence study protocol for FDA review. Three forms of bioequivalence are covered: average bioequivalence (ABE), population bioequivalence (PBE) and individual bioequivalence (IBE). The method of analysis is based on Jones and Kenward (2003) and a modification of their SAS Macro is provided.

Empirical Efficiency Maximization, Daniel B. Rubin, Mark J. Van Der Laan

U.C. Berkeley Division of Biostatistics Working Paper Series

It has long been recognized that covariate adjustment can increase precision, even when it is not strictly necessary. The phenomenon is particularly emphasized in clinical trials, whether using continuous, categorical, or censored time-to-event outcomes. Adjustment is often straightforward when a discrete covariate partitions the sample into a handful of strata, but becomes more involved when modern studies collect copious amounts of baseline information on each subject.

The dilemma helped motivate locally efficient estimation for coarsened data structures, as surveyed in the books of van der Laan and Robins (2003) and Tsiatis (2006). Here one fits a relatively small working model …

Variable Selection For Nonparametric Varying-Coefficient Models For Analysis Of Repeated Measurements, Lifeng Wang, Hongzhe Li

UPenn Biostatistics Working Papers

Nonparametric varying-coefficient models are commonly used for analysis of data measured repeatedly over time, including longitudinal and functional responses data. While many procedures have been developed for estimating the varying-coefficients, the problem of variable selection for such models has not been addressed. In this article, we present a regularized estimation procedure for variable selection for such nonparametric varying-coefficient models using basis function approximations and a group smoothly clipped absolute deviation penalty (gSCAD). This gSCAD procedure simultaneously selects significant variables with time-varying effects and estimates unknown smooth functions using basis function approximations. With appropriate selection of the tuning parameters, we have …

Development Of Informative Priors In Microarray Studies, Kassandra M. Fronczyk

Theses and Dissertations

Microarrays measure the abundance of DNA transcripts for thousands of gene sequences, simultaneously facilitating genomic comparisons across tissue types or disease status. These experiments are used to understand fundamental aspects of growth and development and to explore the underlying genetic causes of many diseases. The data from most microarray studies are found in open-access online databases. Bayesian models are ideal for the analysis of microarray data because of their ability to integrate prior information; however, most current Bayesian analyses use empirical or flat priors. We present a Perl script to build an informative prior by mining online databases for similar …

Adjustment To The Mcnemar’S Test For The Analysis Of Clustered Matched-Pair Data, William F. Mccarthy

COBRA Preprint Series

This paper presents how one can adjust the McNemar’s test for the analysis of clustered matched-pair data. A McNemar’s-like table for K clusters of matched-pair data is used.

Assessment Of Sample Size And Power For The Analysis Of Clustered Matched-Pair Data, William F. Mccarthy

COBRA Preprint Series

This paper outlines how one can determined the sample size or power of a study design that is based on clustered matched-pair data. Detailed examples are provided.

Transmission Dynamics Of Avian Influenza Among Poultry With And Without Vaccination, Qiao Liang

Mathematics & Statistics ETDs

The continuing avian influenza (AI) out break that began in late 2003 and early 2004 has been disastrous for the poultry industry worldwide. It has resulted in severe socio-economic damage, and it has raised serious concerns for general public health. In this research, we use mathematics to analyze transmission dynamics of AI among poultry. We use a status-based approach to construct systems of differential equations to describe virus transmission dynamics. We develop theoretical means to eradicate the spread of the disease, and we calculate the size of healthy and infected populations during an AI outbreak, and the final population size …

Lachenbruch’S Method For Determining The Sample Size Required For Testing Interactions: How It Compares To Nquery Advisor And O’Brien’S Sas Unifypow., William F. Mccarthy

COBRA Preprint Series

Lachenbruch (1988) proposed a simple method based on the use of orthogonal contrasts to determine the sample size or power for testing main effects and interactions, and uses the normal distribution instead of the non-central F distribution. This method can be used for factorial designs of various size. The example illustrated in this paper considers a 2 x 2 factorial design. This paper will determine both sample size and power of a particular study design with anticipated (assumed) means for each cell of the 2 x 2 factorial design. Lachenbruch’s method will be compared to nQuery Advisor 6.0 (2005) and …

The Existence Of Maximum Likelihood Estimates For The Binary Response Logistic Regression Model, William F. Mccarthy

COBRA Preprint Series

The existence of maximum likelihood estimates for the binary response logistic regression model depends on the configuration of the data points in your data set. There are three mutually exclusive and exhaustive categories for the configuration of data points in a data set: Complete Separation, Quasi-Complete Separation, and Overlap. For this paper, a binary response logistic regression model is considered. A 2 x 2 tabular presentation of the data set to be modeled is provided for each of the three categories mentioned above. In addition, the paper will present an example of a data set whose data points have a …

Statistical Considerations In Designing For Biomarker Detection, Trenton C. Pulsipher

Theses and Dissertations

The purpose of this project is to develop a statistical method for use in rapid detection of biological agents using portable gas chromatography mass spectrometry (GC/MS) devices. Of particular interest is 2,6-pyridinedicarboxylic acid (dipicolinic acid, or DPA), a molecule that is present at high concentrations in spores of Clostridium and Bacillus, the latter of which includes the threat organism Bacillus anthracis, or anthrax. Dipicolinic acid may be useful as a first-step discriminator of the biological warfare agent B. anthracis. The results of experiments with B. anthracis Sterne strain and Bacillus thuringiensis spores lead to a conceptual model for the chemical …

Regression Analysis Of A Disease Onset Distribution Using Diagnosis Data, Jessica G. Young, Nicholas P. Jewell, Steven J. Samuels

U.C. Berkeley Division of Biostatistics Working Paper Series

We consider methods for estimating the effect of a covariate on a disease onset distribution when the observed data structure consists of right-censored data on diagnosis times and current status data on onset times amongst individuals who have not yet been diagnosed. Dunson and Baird (2001) approached this problem using maximum likelihood, under the assumption that the ratio of the diagnosis and onset distributions is monotonic non-decreasing. As an alternative, we propose a two-step estimator, an extension of the approach of van der Laan, Jewell and Petersen (1997) in the single sample setting, that is computationally much simpler and requires …

The Assessment Of The Degree Of Concordance Between The Observed Values And The Predicted Values Of A Mixed-Effect Model Using “Method Of Comparison” Techniques, William F. Mccarthy, Nan Guo

COBRA Preprint Series

In this paper, we present a methodology for determining the degree of concordance between observed and model-based predicted values of a mixed-effect model. In particular, we will compare the degree to which observed and model-based predicted values agree by using ‘method of comparison’ techniques. We will also present the results of the concordance correlation coefficient (CCC).

Reporting And Interpretation In Genome-Wide Association Studies, Jon Wakefield

UW Biostatistics Working Paper Series

In the context of genome-wide association studies we critique a number of methods that have been suggested for flagging associations for further investigation. The p-value is by far the most commonly used measure, but requires careful calibration when the a priori probability of an association is small, and discards information by not considering the power associated with each test. The q-value is a frequentist method by which the false discovery rate (FDR) may be controlled. We advocate the use of the Bayes factor as a summary of the information in the data with respect to the comparison of the null …

A Modified Cluster-Weighted Approach To Nonlinear Time Series, Mark Ballatore Lyman

Theses and Dissertations

In many applications involving data collected over time, it is important to get timely estimates and adjustments of the parameters associated with a dynamic model. When the dynamics of the model must be updated, time and computational simplicity are important issues. When the dynamic system is not linear the problem of adaptation and response to feedback are exacerbated. A linear approximation of the process at various levels or “states” may approximate the non-linear system. In this case the approximation is linear within a state and transitions from state to state over time. The transition probabilities are parametrized as a Markov …

Assessment Of A Cgh-Based Genetic Instability, David A. Engler, Yiping Shen, J F. Gusella, Rebecca A. Betensky

Harvard University Biostatistics Working Paper Series

No abstract provided.

Survival Analysis With Large Dimensional Covariates: An Application In Microarray Studies, David A. Engler, Yi Li

Harvard University Biostatistics Working Paper Series

Use of microarray technology often leads to high-dimensional and low- sample size data settings. Over the past several years, a variety of novel approaches have been proposed for variable selection in this context. However, only a small number of these have been adapted for time-to-event data where censoring is present. Among standard variable selection methods shown both to have good predictive accuracy and to be computationally efficient is the elastic net penalization approach. In this paper, adaptation of the elastic net approach is presented for variable selection both under the Cox proportional hazards model and under an accelerated failure time …

A Comparative Simulation Study Of Robust Estimators Of Standard Errors, Natalie Johnson

Theses and Dissertations

The estimation of standard errors is essential to statistical inference. Statistical variability is inherent within data, but is usually of secondary interest; still, some options exist to deal with this variability. One approach is to carefully model the covariance structure. Another approach is robust estimation. In this approach, the covariance structure is estimated from the data. White (1980) introduced a biased, but consistent, robust estimator. Long et al. (2000) added an adjustment factor to White's estimator to remove the bias of the original estimator. Through the use of simulations, this project compares restricted maximum likelihood (REML) with four robust estimation …