Digital Commons Network^™

Activation Of Matrix Metalloproteinases Following Anti-Aβ Immunotherapy; Implications For Microhemorrhage Occurrence, Donna M. Wilcock, Dave Morgan, Marcia N. Gordon, Tiffany L. Taylor, Lisa A. Ridnour, David A. Wink, Carol A. Colton

Sanders-Brown Center on Aging Faculty Publications

BACKGROUND: Anti-Aβ immunotherapy is a promising approach to the prevention and treatment of Alzheimer's disease (AD) currently in clinical trials. There is extensive evidence, both in mice and humans that a significant adverse event is the occurrence of microhemorrhages. Also, vasogenic edema was reported in phase 2 of a passive immunization clinical trial. In order to overcome these vascular adverse effects it is critical that we understand the mechanism(s) by which they occur.

METHODS: We have examined the matrix metalloproteinase (MMP) protein degradation system in two previously published anti-Aβ immunotherapy studies. The first was a passive immunization study in which …

Getting Noticed: Middle Childhood In Cross-Cultural Perspective, David F. Lancy, M. Annette Grove

Sociology, Social Work and Anthropology Faculty Publications

Although rarely named, the majority of societies in the ethnographic record demarcate a period between early childhood and adolescence. Prominent signs of demarcation are: for the first time, pronounced gender separation in fact and in role definition; increased freedom of movement for boys while girls may be bound more tightly to their mothers; and heightened expectations for socially responsible behavior. But, above all, middle childhood is about coming out of the shadows of community life and assuming a distinct, lifetime character. Naming and other rites of passage sometimes acknowledge this transition, but it is, reliably, marked by the assumption or …

'The Earth Is Crying Out In Pains Of Childbirth': Bauxite Mining And Sustainable Rural Development In The Brazilian Atlantic Forest, Lena R. Connor

Environmental Analysis Program Mellon Student Summer Research Reports

In 2003, residents of the Serra do Brigadeiro Territory, a rural region of Southeastern Brazil in one of the few remaining patches of the Atlantic Forest, learned of a large number of bauxite concessions in their territory given by the federal government to the prominent Companhia Brasileira de Alumínio (CBA), Brazil’s largest aluminum producer. Because the region prides itself on its small-scale agriculture and its lush natural environment, the mining has been the source of much contention in the community. Introduced to the topic by the international conservation non-profit and research center, Iracambi, I spent two months in the territory …

An Extension Of Life Course Theory Into The Child Welfare System, Shaun M. Gann

Theses and Dissertations

Over the past 20 years, Sampson and Laub's age-graded theory of informal social control, or life course theory, has become the epitome of developmental criminological theories. Life course theory is based on the premise of life trajectories that are influenced by turning points. Much research has examined possible turning points in the adult life course, such as marriage, employment, military service, and childbirth. However, few studies have attempted to determine possible turning points in the juvenile life course. In an attempt to address this lack of knowledge on juvenile turning points, this thesis presents an extension of life course theory …

Civic Attitude And Activity Of Loma Linda University Dental Graduates, Gregory W. Olson

Loma Linda University Electronic Theses, Dissertations & Projects

Introduction: Dentistry is regarded as a profession and granted certain privileges, such as self-regulation. Associated with this status are stated and implied responsibilities which are widely debated. In recent years, dental professionalism seems to be on the decline. Evidence cited includes access-to-care issues and decreased public trust in dentists. In response, academia and professional organizations have developed curricula and statements intended to bolster professionalism. Meanwhile little is known about practicing dentists’ attitudes or participation in health-related civic matters. Objectives: This study seeks to examine the importance Loma Linda University (LLU) dental graduates place on public roles, their reported participation in …

The Effect Of Caretaker Separations On Indigenous Adolescents, Melissa L. Welch

Department of Sociology: Dissertations, Theses, and Student Research

The family instability hypothesis has been researched among the general population as well as among African American and Mexican American populations, but not yet among Indigenous families. The purpose of this research was to examine whether experiencing separations from their caretakers (lasting at least one month), and the types of living arrangements that follow, affect Indigenous adolescents’ risk of meeting criteria for an internalizing, externalizing, or substance use disorder. Diagnostic criteria were assessed in Wave 6 using the Diagnostic Interview Schedule for Children-Revised (DISC-R). The hypothesis that as the number of lifetime separations increases, the risk of meeting criteria for …

Relationship Formation And Stability In Emerging Adulthood: Do Sex Ratios Matter?, Tara D. Warner, Wendy D. Manning, Peggy C. Giordano, Monica A. Longmore

Department of Sociology: Faculty Publications

Research links sex ratios with the likelihood of marriage and divorce. However, whether sex ratios similarly influence precursors to marriage (transitions in and out of dating or cohabiting relationships) is unknown. Utilizing data from the Toledo Adolescent Relationships Study and the 2000 U.S. Census, this study assesses whether sex ratios influence the formation and stability of emerging adults’ romantic relationships. Findings show that relationship formation is unaffected by partner availability, yet the presence of partners increases women’s odds of cohabiting, decreases men’s odds of cohabiting, and increases number of dating partners and cheating among men. It appears that sex ratios …

Examining Juvenile Transfer Practices In Arkansas For The Years 2000-2005., Joseph Mcsherry

Theses and Dissertations

There has been a trend over recent decades to hold juvenile offenders more accountable for their actions and punish them more severely, which has resulted in more diverse avenues to transfer these offenders to adult court. This research examines emerging literature related to transfer and sentencing of juvenile offenders in criminal court. Further, this research will explore the characteristics of juvenile offenders transferred in Arkansas between 2000 and 2005. Results of the analysis will be discussed along with implications and limitations of the study.

Evolutionary Theory Of Mate Selection And Partners Of Trans People: A Qualitative Study Using Interpretative Phenomenological Analysis, Amanda Forde

The Qualitative Report

Despite much research into mate selection, non-heterosexual populations are often only included for comparison purposes, while trans people and their partners are overlooked. This study attempts to address this using qualitative methodology to explore the mate selection of the partners of trans people. Six participants were recruited from online communities and interviewed via instant messaging, the results were then analysed using Interpretative Phenomenological Analysis. The author organised the results into four themes. Theme one: Identities/relationships which defy categorisation, Theme Two: Attractive traits and mate selection, Theme Three: Impact of past romantic relationships, other relationships and life changes and Theme Four: …

Family Farming And Economic Cooperation: The Emergence And Decline Of Agrarian Condominios In Southern Brazil, Flavio Sacco Dos Anjos, Eduardo Moyano Estrada, Nadia Vellada Caldas

Journal of Rural Social Sciences

In this work the authors analyze the Condominios as an example of economic cooperation adapted to the characteristics of family farming in the Brazilian state of Santa Catarina. The process of modernization of Brazilian agriculture that took place in the 1960s and 1970s under the military governments is analyzed with special attention to the selective and exclusionary effects this process had on the small farmers, along with a study of the development of cooperativism. The consolidation of macro-cooperative models demonstrated reflect the interests and characteristics of modernized, export-oriented agriculture. The origins and development of Condominios as an alternative to the …

Of Unsound Mind And Body: A Statistical Test Of The Association Between Intimate Partner Violence And Chronic Physical And Mental Health Outcomes, Darryl Andre Brice

Dissertations (2 year embargo)

A growing body of literature, both academic and in the popular media, has focused on intimate partner violence (IPV) and its consequences. In addition to the acute physical, social, and economic consequence of IPV, IPV clearly causes great stress for IPV women. While research has shown an association between exposure to external stressors and poor chronic physical and mental health, known as the "stress-health hypothesis," few studies have extrapolated this to examine IPV as a stressor. The goal of this research is to do just that using preexisting data from the Chicago Women's Health Risk Study (CWHRS). The CWHRS is …

Evaluation Of The Global Association Between Cholesterol-Associated Polymorphisms And Alzheimer's Disease Suggests A Role For Rs3846662 And Hmgcr Splicing In Disease Risk, Christopher R. Simmons, Fanggeng Zou, Steven G Younkin, Steven Estus

Sanders-Brown Center on Aging Faculty Publications

BACKGROUND: Recent genome-wide association studies (GWAS) have identified single nucleotide polymorphisms (SNP)s that are essentially unequivocally associated with peripheral cholesterol. Since the alleles of the APOE gene, which modulate peripheral cholesterol metabolism, and midlife plasma cholesterol are both associated with Alzheimer's disease (AD) risk, we have evaluated the hypothesis that SNPs associated with plasma cholesterol are also associated with AD.

RESULTS: Seventeen non-APOE SNPs reproducibly associated with cholesterol per GWAS were tested for association with AD in ~2,000 AD and ~4,000 non-AD subjects. As a group, these SNPs are associated with AD. Two SNPs in particular, rs3846662 and rs1532085, are …

Substance Abuse And Mental Disorders Among State And Federal Prison Inmates., John Richard Haggerty

Electronic Theses and Dissertations

Research consistently demonstrates that prison inmates are more likely than the general population to suffer from both mental disorders and substance abuse. The current study explored the relationship between diagnoses of mental disorders and maladaptive substance use among state and federal prison inmates. Linear regression analysis was used to ascertain the prevalence of comorbidity of substance abuse and mental disorder, and multiple models were constructed to determine the direction of relationship between the two disorders. Overall, mental disorders and substance use were positively related within the sample, though mixed conclusions were drawn regarding the exact nature of their relationship. Recommendations …

Psychopathy And Gender Of Serial Killers: A Comparison Using The Pcl-R., Chasity Shalon Norris

Electronic Theses and Dissertations

Psychopathy and serial murder are 2 of society's most devastating and least understood tribulations. Even less is comprehended with regards to the differences in the way these ills are expressed between the genders. In this study, psychopathic personality traits are considered in a sample comparison of male and female serial murderers. Traits are measured using questions derived from Hare's Psychopathy Checklist Revised (PCL-R, 1991). A content analysis was performed to score the components for each subject, using known and accepted biographical and personal interview materials. Findings showed a distinct difference between the sexes, with females scoring lower than their male …

Identifying Interventions That Work In Juvenile Justice: An Analysis Of The Moral Kombat Program., Thelma Deneen Mcgowan

Electronic Theses and Dissertations

Effective intervention programs play a fundamental role in reducing rates of juvenile delinquency. Cognitive behavioral therapy (CBT) is an evidence-based psychotherapy that is strongly supported by research (ACT, 2010). Moral Kombat (MK) is an intervention that combines character-building and CBT concepts in programs for at-risk and delinquent juveniles with the goal to change their belief systems, thus improving their behaviors (Marchant, 2009). The purpose of the study was to evaluate the extent to which MK incorporates the principles identified in the literature as necessary for a CBT program to be successful. The occurrences of the 11 CBT principles identified in …

Does Decertification Work? Outcome Analysis Of The National Football Leagues Negotiated Order (1986-2008)., Matthew Bowers

Electronic Theses and Dissertations

For decades, union membership and activity has been declining in North America; employers have demanded greater flexibility and have successfully weakened workplace and worker protections. Modern workers increasingly use alternative strategies to negotiate conditions of employment with managers who have limited their discretionary power. Negotiated order theory provides a useful tool for analyzing the mesostructural arrangements of bargaining parties during labor disputes. This thesis applies negotiated order theory to explore how and why the National Football League (NFL) players have twice decertified their union and sought court intervention to challenge the legitimacy of the League's highly restrictive reserve system. An …

Gender Differences In The Effects Of Exposure To Intimate Partner Violence On Adolescent Violence And Drug Use, Abigail A. Fagan, Emily M. Wright

Criminology and Criminal Justice Faculty Publications

Objective

This study investigated the long-term effects of exposure to intimate partner violence in the home on adolescent violence and drug use and gender differences in these relationships. Although the general relationship between exposure to IPV and negative outcomes for youth has been demonstrated in past research, gender differences in the effects of IPV on adolescents have been rarely assessed using longitudinal data.

Methods

Longitudinal data was obtained from 1,315 adolescents and their primary caregivers participating in the Project on Human Development in Chicago Neighborhoods (PHDCN). The sample was 51% female and ethnically diverse (45% Hispanic, 37% African-American, and 14% …

Book Review: Essential Criminology 3rd Edition, Roger Schaefer

Journal of Theoretical and Philosophical Criminology

No abstract provided.

Redefining Genocide: The International Criminal Court’S Failure To Indict On The Darfur Situation, Simeon Sungi

Journal of Theoretical and Philosophical Criminology

No abstract provided.

Strong Ties And Strong Influences: Social Networks And Hiv Prevention, Nicole M. Wengerd

Master's Theses - Sociology and Anthropology

This research builds on the social-oriented literature of HIV-risk behaviors in Gondar, Ethiopia by investigating influential social networks and why individuals would deviate from the norms established by their community.

Rethinking The Rural-Urban Divide In China’S New Stratification Order, Qian Forrest Zhang

Research Collection School of Social Sciences

I use a Marxist framework centred on the mode of production to conceptually analyze the changing stratification structure in today’s China with a focus on the changing nature of rural-urban inequality. As the state-managed tributary mode of production, once dominant under socialism, is being gradually eclipsed by the reviving petty-commodity mode of production and the newly emerged capitalist mode of production, both of which are market-based and enable the transfer of surplus from labour to capital, a new set of mechanisms are creating and sustaining rural-urban inequality in China. Rural-urban inequality – although still significant in its magnitude – is …

An Analysis Of Non-Traditional Intervention Programs For At-Risk Youth, Christine Moore

All Theses

ABSTRACT
Through content analysis, this thesis analyzes relevant wilderness therapy programs and residential treatment centers specifically designed for at-risk youth. More specifically, this study is an applied analysis. The results provide primary care-givers with a guide for assessing programs before their adolescent continues down the path to juvenile incarceration. The study analyzed 20 wilderness therapy programs and 19 residential treatment centers through a series of exploratory questions derived from empirical research concerning the effective and ethically sound treatment of at-risk youth.
The five research questions are as follows:
1) What aspects of the program promote and include family involvement?
2) …

Medicalization As A Trojan Horse: Changes In Erectile Enhancement Advertising, Robert Wood

Theses and Dissertations

Medicalization as a Trojan Horse: Changes in Erectile Enhancement Advertising By Robert D Wood, M.S. A Thesis submitted in partial fulfillment of the requirements for the degree of Master of Science at Virginia Commonwealth University Virginia Commonwealth University, 2011 Major Director: Sarah Jane Brubaker, PhD, Graduate Program of Sociology This thesis investigates the medicalization of “inadequate penis size” through an analysis of online advertising of “male enhancement,” or erectile enhancement (EE) products. The process of medicalization, as defined by Peter Conrad, is the process by which non-medical problems become defined and treated as such (2007). With the advent and success …

The Rights Of Children Affected By Aids: A Policy Paper Focusing On The Right To Education, Gita Jaffe

All Dissertations

HIV and AIDS have the potential to surpass every catastrophe in Africa's history, because they encompass all of the past vulnerabilities. Thirty years after the identification of HIV, a transition from medical disease to social epidemic has occurred. The impact on family and community is threatening current economic, medical and social systems. In sub-Saharan Africa (SSA), the region most adversely affected, 14 million children have already been orphaned (UNAIDS, 2008). And at the core of the burgeoning orphan crisis, children affected by AIDS (CABA) are unable to exercise their rights, based on their position in society. This paper will concentrate …

Addiction And Sociality: Perspectives From Methamphetamine Users In Suburban Usa, Paul Boshears, Miriam W. Boeri, Liam Harbry

Faculty Articles

This article contributes to a growing body of literature that emphasizes the social nature of drug use, abuse and addiction. Current discourses of addiction tend to focus on the individual while limiting attention on the social environment and the role of sociality. We seek to contribute a more intuitive, insiders'' perspective of the drug trajectory and a broader conceptualization of addiction. Drawing from our qualitative study on 100 current and former methamphetamine users in the suburbs of Atlanta, Georgia (USA), we examined the trajectories of methamphetamine use to provide greater insight on what influences drug initiation, progression, cessation and relapse …

Married And Cohabiting Men's Extra-Dyadic Relationships In Sub-Saharan Africa: Assessing Two Health Behavior Models, Jared L. Ulschmid

Master's Theses - Sociology and Anthropology

Sixty percent of all individuals with HIV live in sub-Saharan Africa. HIV is primarily transmitted through sexual activity; having multiple congruent sexual partners is one significant source of HIV transmission in sub-Saharan African. Men are primarily the individuals to go outside of a relationship because of various social and cultural influences. The purpose of this study is to examine married and cohabiting men’s extra-dyadic affairs. Two models were used to examine men’s extra-dyadic behavior: The Health Belief Model (HBM) and Theory of Planned Behavior (TPB). These models can show if beliefs, attitudes, and norms about HIV/AIDS and the risks of …

Epigenetic Silencing Of Nucleolar Rrna Genes In Alzheimer's Disease, Maciej Pietrzak, Grzegorz Rempala, Peter T. Nelson, Jing-Juan Zheng, Michal Hetman

Sanders-Brown Center on Aging Faculty Publications

BACKGROUND: Ribosomal deficits are documented in mild cognitive impairment (MCI), which often represents an early stage Alzheimer's disease (AD), as well as in advanced AD. The nucleolar rRNA genes (rDNA), transcription of which is critical for ribosomal biogenesis, are regulated by epigenetic silencing including promoter CpG methylation.

METHODOLOGY/PRINCIPAL FINDINGS: To assess whether CpG methylation of the rDNA promoter was dysregulated across the AD spectrum, we analyzed brain samples from 10 MCI-, 23 AD-, and, 24 age-matched control individuals using bisulfite mapping. The rDNA promoter became hypermethylated in cerebro-cortical samples from MCI and AD groups. In parietal cortex, the rDNA promoter …

Suicide Risk At Young Adulthood: Continuities And Discontinuities From Adolescence, Carole Hooven, Karen A. Snedker, Elaine Adams Thompson

Sociology Faculty Articles and Research

Young adult suicide is an important social problem, yet little is known about how risk for young adult suicide develops from earlier life stages. In this study the authors report on 759 young adults who were potential high school dropouts as youth. At both adolescence and young adulthood, measures of suicide risk status and related suicide risk factors are collected. With a two-by-two classification on the basis of suicide risk status at both adolescence and young adulthood, the authors distinguish four mutually exclusive groups reflecting suicide risk at two life stages. Using ANOVA and logistic regression, both adolescent and young …

Who’S Pandemic Influenza Preparedness Framework: A Milestone In Global Governance For Health, Lawrence O. Gostin, David P. Fidler

Georgetown Law Faculty Publications and Other Works

In May 2008, the World Health Organization (WHO) adopted the Pandemic Influenza Preparedness Framework for the Sharing of Influenza Viruses and Access to Vaccines and Other Benefits (PIP Framework). The PIP Framework’s adoption ended years of difficult negotiations, which began after Indonesia refused to share samples of avian influenza A (H5N1) with WHO in late 2006. Indonesia justified its actions on the need to create more equitable access for developing countries to benefits, such as vaccines and antivirals, derived from research and development on shared influenza virus samples. The global health community feared that failure to share influenza virus samples …

Religion And Infant Mortality In The U.S.: A Preliminary Study Of Denominational Variations, John P. Bartkowski, Xiaohe Xu, Ginny Garcia-Alexander

Sociology Faculty Publications and Presentations

Prior research has identified a number of antecedents to infant mortality, but has been focused on either structural (demographic) forces or medical (public health) factors, both of which ignore potential cultural influences. Our study introduces a cultural model for explaining variations in infant mortality, one focused on the role of community-level religious factors. A key impetus for our study is well-established religious variations in adult mortality at the community level. Seeking to extend the growing body of research on contextual-level effects of religion, this study examines the impact of religious ecology (i.e., the institutional market share of particular denominational traditions) …