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Quantile-Optimal Policy Learning Under Unmeasured Confounding, Zhongren Chen, Siyu Chen, Zhengling Qi, Xiaohong Chen, Zhuoran Yang

Cowles Foundation Discussion Papers

We study quantile-optimal policy learning where the goal is to find a policy whose reward distribution has the largest α-quantile for some α P p0, 1q. We focus on the offline setting whose generating process involves unobserved confounders. Such a problem suffers from three main challenges: (i) nonlinearity of the quantile objective as a functional of the reward distribution, (ii) unobserved confounding issue, and (iii) insufficient coverage of the offline dataset. To address these challenges, we propose a suite of causal-assisted policy learning methods that provably enjoy strong theoretical guarantees under mild conditions. In particular, to address (i) and (ii), …

The Significance Of Labels: From Shy And Lazy To Autistic And Adhd, Katrine K. Bechsgaard

Ought: The Journal of Autistic Culture

This article examines the ways in which language and conceptions of neurodivergent conditions, autism and ADHD, are connected in a Danish context. As in other Western countries, there are significant increases in diagnoses, and particularly women are being diagnosed in adulthood. The article focuses on how these conditions are perceived and talked about, utilizing concepts such as othering, labeling, and performativity. The analysis suggests that when individuals feel othered and stigmatized by diagnostic labels, it has less to do with the labels themselves and more to do with the connotations and pathologization connected with the labels. Furthermore, the analysis shows …

My Mind In Middlemarch, Margaret A. Fisher

Ought: The Journal of Autistic Culture

“My Mind in Middlemarch” is a creative-critical essay and personal narrative of self-diagnosis. It was modeled in length and (somewhat) in style on Rebecca Mead’s essay, “Middlemarch and Me,” which appeared in The New Yorker in 2011 and was later expanded into her book, My Life in Middlemarch (2014). This personal essay narrates my journey to self-diagnosis and the initial discovery of my autism— a realization sparked by the resonance I found between my life and that of Dorothea Brooke, the central heroine of George Eliot’s classic British novel.

Identity Ramifications, Tina E. Wilson

Ought: The Journal of Autistic Culture

No abstract provided.

Inside Out: Autistic Psychologists On The Power Structures Of Diagnosis, Audrey J. Scaer, Christopher R. Dabbs

Ought: The Journal of Autistic Culture

How do relationships between medicalized diagnostic powers and training intersect with the complex social identity of autism? How does self-identification (self-diagnosis) challenge the diagnostic status quo, created and scaffolded by enormously powerful social systems? In this paper, we reflect on the historical and modern dynamics of these power relations. As autistic psychologists actively working with and diagnosing autistic clients, we end this paper with an autoethnographic interrogation of our own self-diagnostic journeys and ways in which we’ve integrated our identities across personal and professional spheres of functioning.

Does Schooling Improve Cognitive Abilities At Older Ages? Causal Evidence From Nonparametric Bounds, Vikesh Amin, Jere R. Behrman, Jason M. Fletcher, Carlos A. Flores, Alfonso Flores-Lagunes, Hans-Peter Kohler

Upjohn Institute Working Papers

We revisit much-investigated relationships between schooling and health, focusing on schooling impacts on cognitive abilities at older ages using the Harmonized Cognition Assessment Protocol in the Health & Retirement Study (HRS) and a bounding approach that requires relatively weak assumptions. Our estimated upper bounds on the population average effects indicate potentially large causal effects of increasing schooling from primary to secondary; yet, these upper bounds are smaller than many estimates from the literature on causal schooling impacts on cognition using compulsory-schooling laws. We also cannot rule out small and null effects at this margin. We do, however, find evidence for …

From Prohibition To Prescription: Exploring Injustice, Bias, And Science-Based Solutions, Alexander Campos

University Honors Theses

This thesis critiques the war on drugs for disproportionately targeting minority communities and prioritizing systemic exploitation over public health. It examines the flawed, politically influenced DEA drug scheduling process, which neglects evidence of the medical benefits of substances like cannabis, psilocybin, LSD, DMT, and MDMA. This thesis gives a brief history of the evolution of US drug policy, which contributed to mass incarceration, reinforced racial disparities, and failed to reduce overdose deaths. It also highlights the potential mental health benefits of decriminalizing and regulating psychedelics to treat conditions like PTSD, depression, and substance abuse disorder. This thesis concludes by promoting …

Patterns Of Late Holocene And Historical Extinctions On Madagascar, Laurie R. Godfrey, Zachary S. Klukkert, Brooke E. Crowley, Robin R. Dawson, Peterson Faina, Benjamin Z. Freed, Evon Hekkala, Cortni Borgerson, Harimanjaka A.M. Rasolonjatovo, Patricia C. Wright, Stephen J. Burns

Department of Anthropology Faculty Scholarship and Creative Works

Around 1000 years ago, Madagascar experienced the collapse of populations of large vertebrates that ultimately resulted in many species going extinct. The factors that led to this collapse appear to have differed regionally, but in some ways, key processes were similar across the island. This review evaluates four hypotheses that have been proposed to explain the loss of large vertebrates on Madagascar: Overkill, aridification, synergy, and subsistence shift. We explore regional differences in the paths to extinction and the significance of a prolonged extinction window across the island. The data suggest that people who arrived early and depended on hunting, …

The Influence Of Father Involvement On Early Childhood Outcome In China, Shuiyan Guo

Theses and Dissertations

Using a sample from China, this study examined the influence of father involvement on child outcome in early childhood in areas of internalizing problems, externalizing problems and prosocial behaviors. The participants were drawn from the larger PACIFIC project, a cross-cultural study of family processes in Asia. 479 families with a preschool or kindergarten child living in Beijing and Dalian, China were included in this study. Using multiple regression analysis, result indicated that father involvement was not significantly associated with child’s internalizing problems, externalizing problems, and prosocial behaviors. Moderation analysis was also conducted and found that the effect of father involvement …

Therapist Experience As A Moderator Of Therapeutic Alliance Across The Course Of Couple Therapy, Julia K. Christensen

Theses and Dissertations

Therapeutic alliance is a key predictor of successful couple therapy outcomes. Little research has explored how therapist experience may predict its development. This study was designed to examine whether initial therapeutic alliance scores differ between couple clients of training clinics versus couple clients of community clinics, and whether the rate of change in alliance across sessions varies between these groups. Additionally, I controlled for initial relationship distress. Using dyadic therapy process data for at least one partner of 1,330 couples, a multilevel growth curve model with therapist experience as a moderator was fit to determine the difference in initial therapeutic …

Mindfulness-Based Stress Reduction And Mindfulness-Based Cognitive Therapy As Interventions For Generalized Anxiety Disorder: A Meta-Analytic Review, Amitojeroop Kaur

Honors Scholar Theses

This systematic review and meta-analysis examined the efficacy of mindfulness-based interventions (MBIs), specifically Mindfulness-Based Stress Reduction (MBSR) and Mindfulness-Based Cognitive Therapy (MBCT), in reducing anxiety symptoms in individuals with Generalized Anxiety Disorder (GAD). A review of the literature revealed that while GAD affects millions globally, many individuals diagnosed with GAD do not receive treatment. This review evaluated the effectiveness of MBIs using randomized controlled trials (RCTs) and non-RCTs, focusing on effect sizes, study quality, and control conditions. The central hypothesis was that MBCT would significantly reduce anxiety symptoms, particularly in comparison to inactive control groups. Meta-analytic results showed that MBSR …

The Role Of Gender And Sexual Identity In Mental Health Outcomes For Asylum-Seeking Survivors Of Sexual Torture, Samantha A. M. Doerr

Clinical Psychology Dissertations

Millions of people worldwide flee violent persecution each year, with more than 6.8 million estimated to have sought asylum in 2023 alone (United Nations High Commission on Refugees, 2025). Up to 40% of refugees and asylum-seekers are reported to be survivors of torture, with sexual torture one of the most commonly-reported means of torture, particularly among women and LGBTQ+ populations (Abu Suhaiban, 2019; Hopkinson et al., 2017; United Nations High Commission on Refugees, 2017). Sexual torture has been associated with severe impacts on mental health, including posttraumatic and depressive symptoms. Despite marked differences in sexual torture risk across gender and …

Intersectionality And Experiences With Mental Health Care: Transgender And Gender Diverse Autistic Adults, Megan Callahan

LSU Doctoral Dissertations

Current prevalence rates of autism spectrum disorder (ASD) in transgender and gender diverse (TGD) populations range between 4 and 13% (Thrower et al., 2020). Studies into autistic TGD individuals’ experiences with healthcare have primarily collected qualitative data, identifying themes including barriers to healthcare, invalidation of both autistic and TGD identities, difficulty finding competent providers, limited support and resources, and refusal of care (Cooper et al., 2022; Maroney & Horne, 2022; Hall et al., 2020). N = 3094 self-identified TGD adults completed the 2017 TransLifeline Mental Health Survey, a collaborative effort between the National LGBTQ Task Force and the TransLifeline, which …

Masculine Traits In Female Serial Killers: A Qualitative Analysis, Ashley Polk

Walden Dissertations and Doctoral Studies

Female serial killers represent a minority in criminal statistics; their cases offer significant insights regarding broader patterns of serial killing behavior. The purpose of this study is to understand the role masculine traits play in the lives of female serial killers. This study involved using a qualitative research method to understand specific characteristics of female serial killers with common masculine traits and childhood experiences. Common masculine traits researched in this study were lack of emotions, aggression, control, dominance, and manipulation. The trauma control model and the gender scheme theory were the theoretical frameworks for this study. Data were collected by …

An Exploration Of The Lived Experiences Of Black Female Kinship Caregivers In Parenting Youth Aged 13-18, Tyla Wilder

Walden Dissertations and Doctoral Studies

This qualitative phenomenological study explored how the intersection of identities related to race and gender shapes the lived experiences of Black female kinship caregivers raising youth aged 13–18. Drawing on Intersectionality Theory, the study sought to understand the caregiving challenges, emotional resilience, and systemic barriers encountered by this underrepresented population. Nine participants were recruited through purposive and snowball sampling and engaged in in-depth semi-structured interviews. Thematic analysis revealed that cultural norms and racialized gender expectations often compelled Black females to assume caregiving roles without institutional recognition or support. Participants described emotional isolation, financial instability, and limited access to legal and …

Prediction Of Methotrexate Neurotoxicity Using Clinical, Sociodemographic, And Area-Based Information In Children With Acute Lymphoblastic Leukemia, Rachel D Harris, Olga A Taylor, Maria Monica Gramatges, Amy E Hughes, Mark Zobeck, Sandi Pruitt, M Brooke Bernhardt, Ashley Chavana, Van Huynh, Kathleen Ludwig, Laura Klesse, Kenneth Heym, Timothy Griffin, Rodrigo Erana, Juan Carlos Bernini, Ashley Choi, Yuu Ohno, Melissa A Richard, Alanna C Morrison, Han Chen, Bing Yu, Philip J Lupo, Karen R Rabin, Michael E Scheurer, Austin L Brown

Center for Medical Ethics and Health Policy Staff Publications

Background: Methotrexate is a critical component of pediatric acute lymphoblastic leukemia (ALL) therapy that can result in neurotoxicity which has been associated with an increased risk of relapse. We leveraged machine learning to develop a neurotoxicity risk prediction model in a diverse cohort of children with ALL.

Methods: We included children (age 2-20 years) diagnosed with ALL (2005-2019) and treated in Texas without pre-existing neurologic disease. Clinical information was obtained by medical record review. Neurotoxicity occurring post-induction and prior to maintenance therapy was defined as neurologic episodes occurring within 21 days of methotrexate. Suspected cases were independently confirmed by 2 …

Sunrise At The Salton Sea: Environmental Justice, Land Use Change, And Hydrosocial Dynamics Of Solar Energy Transitions In The Imperial Valley, California, Dustin Mulvaney, James J. A. Blair, Alida Cantor

Geography Faculty Publications and Presentations

California's Imperial Valley, with lithium-rich geothermal brines, extensive flat agricultural fields with abundant desert sunshine, and access to transmission lines, is a leading case to explore interconnected themes around just energy transitions. Despite being the poorest county in California and one of the smallest, Imperial already provides 15% of the state’s solar electricity, and the region as a whole represents on the order of 25% of the state’s electric power capacity. This paper brings to light frictions over solar energy development that have emerged over the history of solar power development in the southern Salton Sea region. It describes the …

Unseen Burdens: Exploring Gender Disparities In Infertility Experience And Depressive Symptoms, Khiara Cardoza Brown

Theses and Dissertations

This study examines how experiences with infertility relate to mental health outcomes among newly married U.S. couples, emphasizing gender differences and the potential moderating role of gender attitudes. Using data from 3,137 individuals in a nationally representative sample, three Actor-Partner Interdependence Models were estimated: first assessing actor and partner effects of infertility on depressive symptoms and subsequently incorporating gender attitudes as moderators. Results indicated a significant actor effect for wives, where infertility was associated with higher levels of depressive symptoms, and this association was significantly stronger for wives than for husbands. No significant effects were found for husbands' infertility and …

Adoption, Friendships, And Social Skills, Alexis M. Chelle

Sociology Undergraduate Senior Theses

Adoption functions as both an identity status and a source of unique social benefits and challenges for teenagers, informing their experience of friendship. While prior research primarily focuses on individual outcomes and difficulties that adoptees face, such as trauma-related disorders and social skill deficits, it often overlooks how adoptees and their parents perceive these impacts on peer relationships. This study draws on twenty-one in-depth interviews with adoptees ages thirteen to twenty-one and their adoptive parents to explore the role that adoption and adverse childhood experiences have on an adopted teen’s experience of friendships. Findings reveal that despite facing significant social …

Maternal Loss Of Mouse Nlrp2 Alters The Transcriptome And Dna Methylome In Gv Oocytes And Impairs Zygotic Genome Activation In Embryos, Zahra Anvar, Michael D Jochum, Imen Chakchouk, Momal Sharif, Hannah Demond, Alvin K To, Daniel C Kraushaar, Ying-Wooi Wan, Michael C Mari, Simon Andrews, Gavin Kelsey, Ignatia B Van Den Veyver

Center for Medical Ethics and Health Policy Staff Publications

Background: NLRP2 is a subcortical maternal complex (SCMC) protein of mammalian oocytes and preimplantation embryos. SCMC proteins are encoded by maternal effect genes and play a pivotal role in the maternal-to-zygotic transition (MZT), early embryogenesis, and epigenetic (re)programming. Maternal inactivation of genes encoding SCMC proteins has been linked to infertility and subfertility in mice and humans, but the underlying molecular mechanisms for the diverse functions of SCMC proteins, and specifically the role of NLRP2, are incompletely understood.

Results: We profiled the DNA methylome of pre-ovulatory germinal-vesicle (GV) oocytes from Nlrp2-null, heterozygous (Het), and wild-type (WT) female mice and assessed the …

Xbp1s-Edem2 Prevents The Onset And Development Of Hfpef By Ameliorating Cardiac Lipotoxicity, Oveena Fonseka, Rida Raja, Claire Ross, Sanskruti R Gare, Jiayan Zhang, Susanne S Hille, Katharine King, Andrea Ruiz-Velasco, Namrita Kaur, Xinyi Chen, Jessica M Miller, Riham R E Abouleisa, Qinghui Ou, Zhiyong Zou, Xiangjun Zhao, Cristian Sotomayor-Flores, Derk Frank, Eileithyia Swanton, Martin R Pool, Sara Missaglia, Daniela Tavian, Gabriele G Schiattarella, Tao Wang, Luigi Venetucci, Christian Pinali, Martin K Rutter, Bernard D Keavney, Elizabeth J Cartwright, Tamer M A Mohamed, Oliver J Müller, Wei Liu

Center for Medical Ethics and Health Policy Staff Publications

Background: Morbidity and mortality of heart failure with preserved ejection fraction (HFpEF) is increased in metabolic disorders. However, options for preventing and treating these prevalent outcomes are limited. Intramyocardial lipotoxicity contributes to cardiac dysfunction. Here, we investigate the mechanisms underlying EDEM2 (endoplasmic reticulum degradation-enhancing alpha-mannosidase-like protein 2) regulation of cardiac lipid homeostasis and assess strategies that inhibit the incidence and progression of HFpEF.

Methods: Metabolic stress was induced in C57BL/6 male mice using a high-fat diet and Nω-nitro-L-arginine methyl ester. The recombinant adeno-associated virus 9 delivery system was used for loss- and gain-of-function studies. Palmitic acid and oleic acid …

A Novel Cardiomyopathy Phenotype Linked To A Chd7 Missense Variant, In Young Park, Chih-Wei Hsu, Karim Bouazoune, Christina E Espindola, Madeline Hannah Mclaughlin Armond, Cristian Coarfa, Sandra L Grimm, James F Martin, Donna M Martin, Cheryl Lyn Walker

Center for Medical Ethics and Health Policy Staff Publications

Loss of function in the chromatin remodeler CHD7 causes CHARGE syndrome, characterized by variable penetrance and diverse abnormalities. However, establishing genotype-phenotype correlations has been challenging, as most CHD7 inactivating mutations are null alleles. Through CHD7 missense variant analysis at potential phosphorylation sites, we identified T730 (T720 in mice) as a critical residue associated with pathogenesis. Using a CHD7 T730 missense variant (Chd7T720A) and a frameshift null allele (Chd7fs) in a mouse model, we found that Chd7fs/fs mice were non-viable, while Chd7fs/+ mice exhibited haploinsufficiency-related circling behavior. Notably, Chd7fs/T720A mice died before postnatal …

Convergence Research For Microplastic Pollution At The Watershed Scale, Heejun Chang, Elise F. Granek, Amanda Gannon, Jordyn M. Wolfand, Janice Brahney

Geography Faculty Publications and Presentations

Microplastics are found in Earth’s atmosphere, lithosphere, hydrosphere, pedosphere, and ecosphere. While there is a growing interest and need to solve this grand challenge in both the academic and policy realms, few have engaged with academics, policymakers, and community partners to co-identify the problem, co-design research, and co-produce knowledge in tackling this issue. Using a convergence research framework, we investigated the perception of microplastic pollution among different end users, delivered educational materials to K-12 teachers and practitioners, and identified key sampling points for assessing environmental microplastic concentrations in the Columbia River Basin, United States. Three community partner workshops identified regional …

Arts-Based Sustainability: From New York To Malawi, Martha B. Lerski

Publications and Research

Recognizing that libraries serve multiple constituencies and subject areas, this chapter documents and advocates for development of transdisciplinary arts-based research (ABR) and culture-related projects linked to environmental challenges. Libraries contribute collections and spaces, as well as the research of library and information scientists. Libraries are currently among invisible contributors to sustainability planning and services. The chapter will link this invisibility to the value of what visual arts refer to as negative space elements in subjects ranging from traditional ecological knowledge to environmental science. Library collections, projects, and research contribute to education for sustainable development (ESD) as required to achieve the …

Ocular Phenotyping Of Knockout Mice Identifies Genes Associated With Late Adult Retinal Phenotypes, Abraham Hang, Andy Shao, Michael Shea, Michel J Roux, Denise M Imai-Leonard, David J Adams, Takanori Amano, Oana V Amarie, Zorana Berberovic, Raphaël Bour, Lynette Bower, Brian C Leonard, Steve D Brown, Soo Young Cho, Sharon Clementson-Mobbs, Abigail J D'Souza, Mary Dickinson, Mohammad Eskandarian, Ann M Flenniken, Helmut Fuchs, Valerie Gailus-Durner, Jason Heaney, Yann Hérault, Martin Hrabe De Angelis, Chih-Wei Hsu, Shundan Jin, Russell Joynson, Yeon Kyung Kang, Haerim Kim, Hiroshi Masuya, Ki-Hoan Nam, Hyuna Noh, Lauryl M J Nutter, Marcela Palkova, Jan Prochazka, Miles Joseph Raishbrook, Fabrice Riet, Jason Salazar, John Richard Seavitt, Radislav Sedlacek, Mohammed Selloum, Kyoung Yul Seo, Je Kyung Seong, Hae-Sol Shin, Toshihiko Shiroishi, Tania Sorg, Michelle Stewart, Masaru Tamura, Heather Tolentino, Uchechukwu Udensi, Sara Wells, Wolfgang Wurst, Atsushi Yoshiki, Hamid Meziane, Glenn Yiu, Paul A Sieving, Louise Lanoue, K C Kent Lloyd, Colin Mckerlie, Ala Moshiri, International Mouse Phenotyping Consortium (Impc)

Center for Medical Ethics and Health Policy Staff Publications

Purpose: Analyze phenotypic data from knockout mice with late-adult retinal pathologic phenotypes to identify genes associated with development of adult-onset retinal diseases.

Methods: The International Mouse Phenotyping Consortium (IMPC) database was queried for genes associated with abnormal retinal phenotypes in the late-adult knockout mouse pipeline (49-80 weeks postnatal age). We identified human orthologs and performed protein-protein analysis and biological pathways analysis with known inherited retinal disease (IRD) and age-related macular degeneration (AMD) genes using Search Tool for the Retrieval of Interacting Genes/Proteins (STRING), PLatform for Analysis of single cell Eye in a Disk (PLAE), Protein Analysis Through Evolutionary Relationships (PANTHER), …

Evaluating Gamified Website Designs: An Analysis Using The Octalysis Framework, Menna Mohamed Zakaria, Reem Alasfoury, Nesrin Ezzat Gamal, Maryet Youssef Bekhit

Journal of Art, Design and Music

In today's fast-changing digital landscape, websites must stand out to gain and retain user attention. Gamification techniques, which use game-design concepts to improve user engagement and satisfaction, are a method to achieve this uniqueness. This research investigates the significant role of purposeful design in the effective application of gamification on websites, emphasising the importance of deliberate and balanced context-specific implementation of gamification By examining industry-leading websites that employ gamification using the Octalysis framework and related theoretical frameworks The findings highlight that, while gamification has the potential to dramatically distinguish the website and boost user interaction and loyalty, its performance and …

United Seas For Resilient Reefs: A Blueprint For Coral Conservation Through International Cooperation, John J. Bohorquez, Maoz Fine, Dana I. Grieco, David A. Gill, Ali Al-Swalimih, Jacqueline Padilla-Gamino, Isaiah W. Bolden, Margaux Hein, Callum Backstrom, Melanie Mcfield, Raphael Martinez, Benjamin Midberry, Fahd Al-Guthmy, Ellen K. Pikitch, Natalia Benejam, Chen Azulay, Britt Ronen, Oren Levy, Anne Mcelroy, Karine Kleinhaus

School of Marine & Atmospheric Sciences Faculty Publications

Coral reefs are one of Earth’s most vital and threatened ecosystems. They protect coastlines, generate billions of dollars of tourism revenue, support valuable fisheries, and contribute to the development of vital medicines. Yet half of the world's coral reefs have been lost in the last 50 years, and 90% of remaining reefs are projected to die off by the middle of this century, mainly due to warming seas from climate change.

Despite these challenges there is reason for hope. Some coral reefs – such as in the northern Red Sea and Gulf of Aqaba – have demonstrated remarkable resilience to …

Opensim Analysis Of The Aymara Indigenous People Performing Ancestral Tasks: Exploring Trends Of Muscle Activity With Tiwanaku Skeletal Indicators, Noah M. Taylor

Master's Theses

The Tiwanaku civilization (AD 500-1100) of the Andean highlands exhibited occupational specialization in communities, with archeological evidence suggesting the existence of labor- and residential-communities, or “taskscapes”, based on an individual’s livelihood. Prior bioarcheological studies have examined Tiwanaku skeletal remains for musculoskeletal stress markers, osteoarthritis, and cross-sectional geometry to infer activity patterns. Their descendants, the Aymara Indigenous people, currently live in the same highlands and until recently lived a lifestyle like their ancestors. Over the past 20 years, the global quinoa demand has risen, thrusting the Aymara into globalization and moving them away from the traditional tasks previously performed. This study …

Functional And Cultural Values Of Shame: A Motivator To Seek Help For Suicidal Ideation, Yu-Chin Lin

Clinical Psychology Dissertations

Suicide is a global issue with rates continuing to rise despite decades of research and prevention efforts. The role of shame in the development of suicidal ideation, especially within non-Western contexts, remains underexplored. This mixed-methods study explored the relationships among shame, suicidal ideation, and help-seeking intentions in a Taiwanese sample, focusing on four culturally distinct Mandarin terms for shame—diu lian, can kui, xiu kui, and xiu chi. A total of 101 participants who has experiences of suicide-related thoughts or behaviors responded to an online survey. Quantitative analyses revealed that all shame terms were strongly correlated …

Une Library Services Quarterly Report June 2025, Une Library Services

Quarterly Reports

Highlights of accomplishments of the University of New England's Library Services department.