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A Phase 1 Trial Utilizing A Pharmacokinetic Endpoint To Determine The Optimal Dose Of Ramucirumab In Children And Adolescents With Relapsed Or Refractory Solid Tumors, Including Central Nervous System Tumors, Kristy L Pilbeam, Kamnesh Pradhan, James Croop, Charles G Minard, Xiaowei Liu, Stephan D Voss, Emasenyie Isikwei, Stacey L Berg, Joel M Reid, Elizabeth Fox, Brenda J Weigel

Center for Medical Ethics and Health Policy Staff Publications

Background: Ramucirumab is a monoclonal antibody that binds the extracellular domain of vascular endothelial growth factor receptor (VEGFR-2) and prevents binding of VEGF ligands. Based on population pharmacokinetic (PK) analysis and correlation with efficacy in adults, a target steady state trough concentration (Css,min ) ≥ 50 µg/mL was established.

Procedures: This phase 1 trial (ADVL1416) used a rolling six design and a PK primary endpoint to define the recommended phase 2 dose (RP2D) of ramucirumab in children with recurrent/refractory solid tumors. Two dose levels (DL) were planned (DL1: 8 mg/kg, DL2: 12 mg/kg administered intravenously [IV] every 2 weeks). Toxicity …

Geographical Variation In Songs Of Bachman’S Sparrow (Peucaea Aestivalis), L. Nguyen, K. Doñas, J. Jackson, R. Kannan

Journal of the Arkansas Academy of Science

We present an analysis of geographic variation in primary song components of the Near Threatened North American endemic, Bachman’s Sparrow (Peucaea aestivalis). These songs have 2 distinct portions: an introductory tweet we call the "whistle" and a more complex second portion that we call the "trill". We analyzed 327 songs from 111 recordings downloaded from eBird.org from the entire current range of the species. We grouped the recordings into 3 distinct geographic clusters, East, Central, and West. The data measured from spectrograms suggest a significant statistical difference among groups for 3 measured characteristics: frequency range of trill, number of horizontal …

Attack On The Brain: Neurowars And Neurowarfare, Armin Krishnan

Space and Defense

Is neurotechnology leading nation-states toward a new domain of war? Neuroscience is on the verge of deciphering the human brain. As a result, brains will become a part of the battlefield against which attacks will be directed. As neuroscientist James Giordano argued: “the brain is the next battlespace.” It is foreseeable that this will have tremendous implications for warfare and could amount to a true military revolution in the sense of military historian Williamson Murray: it would completely change the characteristics of conflict, as well as transform state and society.

Polymorphisms In The Nonhomologous End-Joining Dna Repair Pathway Are Associated With Hpv Integration In Cervical Dysplasia, Jennifer M Geris, E Susan Amirian, Deborah A Marquez-Do, Martial Guillaud, Laura M Dillon, Michele Follen, Michael E Scheurer

Center for Medical Ethics and Health Policy Staff Publications

Previous evidence indicates that HPV integration status may be associated with cervical cancer development and progression. However, host genetic variation within genes that may play important roles in the viral integration process is understudied. The aim of this study was to examine the association between HPV16 and HPV18 viral integration status and single nucleotide polymorphisms (SNPs) in non-homologous end-joining (NHEJ) DNA repair pathway genes on cervical dysplasia. Women enrolled in two large trials of optical technologies for cervical cancer detection and positive for HPV16 or HPV18 were selected for HPV integration analysis and genotyping. Associations between SNPs and cytology (normal, …

Bruno Latour's Constructivism And Its Implications For The New Agency Of Sociology, Robertus Robet, U. Abdul Rozak R

Masyarakat: Jurnal Sosiologi

Abstract

Latour removes the boundaries between natural sciences and humanities. Science for Latour is cultural practise, at the same time in every cultural practice, nature and objects are also actively involved. In that sense, Latour's constructivism encourages the emergence of non-human actors as drivers of the societal changes. By that, he provoked sociology to expand its subject matter. The Social in sociology must be seen as an association involving human and non-human actors.

Key words: Constructivism, Expansion of agency, actant, actor network theory.

Konstruktivisme Bruno Latour Dan Implikasinya Terhadap Ide Keagenan Sosiologi, Robertus Robet, U Abdul Rozak R

Masyarakat: Jurnal Sosiologi

Abstract

Latour removes the boundaries between natural sciences and humanities. Science for Latour is cultural practise, at the same time in every cultural practice, nature and objects are also actively involved. With that, Latour's constructivism encourages the emergence of non-human actors as drivers of the societal changes. With that he provoked sociology to expand its subject matter. The Social in sociology must be seen as an association involving human and non-human actors.

Hello There: An Integrative Framing Analysis Of The Disney+ Series Obi-Wan Kenobi, Hannah Grace Sawchuck

Masters Theses

The effective communication of emotions within audio-visual content, such as film, was one of the most important aspects that needed to be considered when creating such content. Within the field of communication, there was a limited amount of research that existed on the communication of emotions in film. This was a problem as such content is becoming more prevalent in society. Knowing how those emotions were created and developed would allow communication scholars to better understand how to effectively elicit emotions from their own audio-visual content. By examining a well-known series, Obi-Wan Kenobi, scholars could see how different aural and …

'I Don’T Fit That Stereotype': Participant Photography And The Visual (Re)Positioning Of Black Men, Quaylan Allen

Education Faculty Articles and Research

This paper examines how Black men use a participant photography project as a tool for meaning making during the current political and social context of anti-Black racism, Black activism, and intersectional politics. Using a critical visual methodology in the analysis of the images, this paper will examine how Black men make meaning of current social issues through the types of images they produced, how they make meaning of the types of audiences they are speaking to through the project, and how these meanings are reflected through their repositioning practices in the visual project. Specific attention is paid to how they …

Repurposing Atovaquone As A Therapeutic Against Acute Myeloid Leukemia (Aml): Combination With Conventional Chemotherapy Is Feasible And Well Tolerated, Alexandra Mclean Stevens, Eric S Schafer, Minhua Li, Maci Terrell, Raushan Rashid, Hana Paek, Melanie B Bernhardt, Allison Weisnicht, Wesley T Smith, Noah J Keogh, Michelle C Alozie, Hailey H Oviedo, Alan K Gonzalez, Tamilini Ilangovan, Alicia Mangubat-Medina, Haopei Wang, Eunji Jo, Cara A Rabik, Claire Bocchini, Susan Hilsenbeck, Zachary T Ball, Todd M Cooper, Michele S Redell

Center for Medical Ethics and Health Policy Staff Publications

Survival of pediatric AML remains poor despite maximized myelosuppressive therapy. The pneumocystis jiroveci pneumonia (PJP)-treating medication atovaquone (AQ) suppresses oxidative phosphorylation (OXPHOS) and reduces AML burden in patient-derived xenograft (PDX) mouse models, making it an ideal concomitant AML therapy. Poor palatability and limited product formulations have historically limited routine use of AQ in pediatric AML patients. Patients with de novo AML were enrolled at two hospitals. Daily AQ at established PJP dosing was combined with standard AML therapy, based on the Medical Research Council backbone. AQ compliance, adverse events (AEs), ease of administration score (scale: 1 (very difficult)-5 (very easy)) …

The Position Of Insider (Emic) And Outsider (Etic): A Review Of Deborah Court And Randa Khair Abbas’ Insider-Outsider Research In Qualitative Inquiry: New Perspectives On Method And Meaning, Elih Sutisna Yanto, Moses Pandin Mop

The Qualitative Report

In their book, Insider-Outsider Research in Qualitative Inquiry: New Perspectives on Method and Meaning by Deborah Court and Randa Khair Abbas, they deconstruct the outdated or puzzling terminology associated with this type of research, examine ethical challenges, and recommend methodological approaches. This book also situates qualitative insider-outsider research, by its very nature, within the larger research ecology. The authors describe in full a researcher partnership—a relationship that is more personal and fruitful than a team and significantly more than the sum of its parts. Through their nearly two-decade-long research collaboration and study of the Israeli Druze, the authors have established …

Histomorphology Of The Distal Urogenital Ducts In The Male Northern Crawfish Frog, Rana Areolata Circulosa (Anura: Ranidae), S.E. Trauth, R.G. Neal

Journal of the Arkansas Academy of Science

We examined the microanatomy of the distal urogenital ducts in the male Northern Crawfish Frog (Rana areolata circulosa) from a small sample (n = 5) collected in February and March from central Arkansas over a 5-year period (2017–2022). Specifically, we sought information on the following structures: (1) the paired Wolffian (urogenital) ducts caudally from the kidneys to their merging with the urodeum of the cloaca, (2) the paired seminal vesicles (sperm storage structures), and (3) the paired Müllerian ducts and glands. This study provides new information on these urogenital ducts and promotes a clearer understanding of this anatomical region for …

No Sperm Morphometric Differences Between Two Snapping Turtle Species, J.D. Konvalina, S.E. Trauth

Journal of the Arkansas Academy of Science

We examined sperm morphometrics between Chelydra serpentina and Macrochelys temminckii. When both species are combined, we found significant correlations between total sperm length and sperm head length as well as sperm tail length and sperm head length. In addition, we observed significant correlations between total sperm length and sperm tail length. T-tests revealed no significant differences in any of the sperm morphometrics between the two species. Both snapping turtle species had greater values for every sperm morphometric when compared to another freshwater turtle. The strong correlation between total sperm length and sperm tail length is concurrent with what has previously …

Why Representation Matters: Using Stem Education To Promote Opportunity, Sheramie Velazquez

Indiana STEM Education Conference

Research has highlighted how Black and Brown professionals continue to be underrepresented in the various science, technology, engineering and mathematics (STEM) fields. The lack of exposure to diverse STEM professionals, a challenging and relevant STEM curriculum, and belief in the brilliance of Black and Brown scholars’ abilities to succeed in STEM are vast contributors to the continual diversity underrepresentation in STEM-based classes and careers. Girls STEM Institute (GSI) was founded to create a space where girls of color-who are traditionally underrepresented in STEM-can become exposed to challenging and relevant STEM curricula, which is taught by diverse educators who share similar …

A Case Study On The Practice Of Carbon Offset Projects In Michigan: Forest Practitioners’ Perspectives, Zachary B. Hough Solomon

Dissertations, Master's Theses and Master's Reports

This report examines the practice of carbon offset programs on private nonindustrial forestlands in the state of Michigan ass. Previously, the state of Michigan provided technical assistance for enrollment in carbon offsets through the Michigan Working Forest Carbon Offset Program, but this program has now been discontinued. Currently, private companies and nongovernmental organizations are developing projects throughout the state with nonindustrial private landowners. This descriptive analysis in this case study examines the roles of different forest practitioners who are working on carbon offsets, including private consulting foresters and foresters within Michigan public agencies. I review the academic and grey literature …

Wild/Feral Horses: The Great Debate Between Freedom And Capturing, Jolee Lamoreaux

Fall Student Research Symposium 2022

Wild Horses have been around for as long as anyone can remember. However, there has been a great debate that these horses are harmful to the environment and they need to be taken care of either by rehoming or slaughtering. This study aims to determine why people think these horses are harmful and what has been done to try and solve the issue. I conducted my research mostly by researching keywords and evaluating my search results to examine credible sources. The three major claims that I wanted to make sure I addressed in my paper were the history and background …

Full Journal

Humboldt Journal of Social Relations

The theme of Issue 34 of the Humboldt Journal of Social Relations is Social Justice Action, Teaching, and Research.

Partialing Alters Interpersonal Correlates Of Negative Affective Symptoms And Traits: A Circumplex Illustration, Steven E. Carlson, Timothy W. Smith, Paula G. Williams, Kimberly A. Parkhurst, Ruben Tinajero, Christian Goans, Michiyo Hirai, John M. Ruiz

Psychological Science Faculty Publications

Introduction

Negative affective symptoms (e.g., anxiety, depression, and anger) are correlated and have parallel associations with outcomes, as do related personality traits (i.e., facets of neuroticism), often prompting statistical control (i.e., partialing) to determine independent effects. However, such adjustments among predictor variables can alter their construct validity. In three studies, the interpersonal circumplex (IPC) and a related analytic approach (i.e., Structural Summary Method) were used to evaluate changes in interpersonal correlates of negative affective characteristics resulting from partialing.

Methods

Samples of undergraduates (Sample 1 n = 3283; Sample 2 = 688) and married couples (n = 300 couples) completed …

“I’M Not Just Made For Men”: How Online Sex Workers Manage Misogyny, Sarah Dellner

Honors Program Theses and Projects

Online sex work, or erotic labor, refers to sexual services that are provided via the Internet for compensation. Views of sex work range from empowering and agentic for sex workers, rife with violence and victimization. Various frameworks (Jones, 2016 Vance, 1984; Weitzer, 2010) examine the balance between these extremes; but often lacks nuance. I examined female and non-binary online sex workers’ experiences with misogyny and how they cope with it. Zoom interviews were conducted with 15 participants ranging from 18 to 33 years old. Using an intersectional feminist lens and thematic analysis (Braun & Clarke, 2020), two overarching themes were …

Modeling And Analysis Of Subcellular Protein Localization In Hyper-Dimensional Fluorescent Microscopy Images Using Deep Learning Methods, Yang Jiao

UNLV Theses, Dissertations, Professional Papers, and Capstones

Hyper-dimensional images are informative and become increasingly common in biomedical research. However, the machine learning methods of studying and processing the hyper-dimensional images are underdeveloped. Most of the methods only model the mapping functions between input and output by focusing on the spatial relationship, whereas neglect the temporal and causal relationships. In many cases, the spatial, temporal, and causal relationships are correlated and become a relationship complex. Therefore, only modeling the spatial relationship may result in inaccurate mapping function modeling and lead to undesired output. Despite the importance, there are multiple challenges on modeling the relationship complex, including the model …

Biological Sex Differences In The Monodelphis Domestica: Investigating Behavioral Responses In Environmental Enrichment And Conditioned Place Preference Paradigms, Katelynn M. Renteria

Theses and Dissertations

The Monodelphis domestica, commonly known as the grey short-tailed opossum, has become an increasingly frequented animal model for areas of psychological study, including comparative psychology. Despite the growing interest in utilizing the Monodelphis as an animal model, several areas of research remain limited in what has been studied. This includes associative learning and the effects of environmental enrichment on the Monodelphis. This study novelly incorporates the two using environmental enrichment with the conditioned place preference (CPP) paradigm to both diversify associative learning literature and expand existing knowledge on the Monodelphis domestica. The CPP paradigm included interactive objects as environmental …

Young Children’S Tv Show Preferences And Perceptions Of Women In Stem, Lauren Berck

Undergraduate Theses

Women are joining STEM fields at higher rates, yet the stereotype of math and science being for men is still reinforced to children by their parents, their teachers, and especially what they watch. Children tend to trust characters of their same gender and are more likely to retain the lessons from the characters they trust. Since most of the shows children watch tend to display gender stereotypes, especially the stereotype of men being good in STEM, children are likely to enforce these stereotypes. The increase of women in STEM has increased interest in STEM for girls, but boys still tend …

Religiousness And Health Locus Of Control In Polish Physical Education Students, Monika Guszkowska, Anna Kuk

Baltic Journal of Health and Physical Activity

Background: The aim of this research was to determine relationships between religious commitment and health locus of control (HLC) for the group of students of the University of Physical Education in Warsaw, Poland, including gender and study faculty differences. Material/Methods: Full-time students (n = 247) of the Warsaw University of Physical Education were investigated. Religious Commitment Scale (RCS) and Multidimensional Health Locus of Control Scale (MHLC) were used. Results: Few and weak relationships between religious commitment and health locus of control were found; they were stronger within the group of male and physical education students. Cluster analysis by the Ward …

The Diagnostic Value Of Attributes From An Optimum Set Of Variables For Explaining An Outcome In Powerlifting At The Junior Level, Lukasz Plociennik, Igor Rygula, Tomasz Dancewicz, Krzysztof Łukaszuk

Baltic Journal of Health and Physical Activity

The sport of powerlifting has been extensively studied, but there is lack of information on an optimum list of features that explain performance in 19–20-years-old contestants. Therefore, the study aimed at two research objectives: (1) to determine a minimum set of attributes contributing the most information to an outcome; (2) to develop a biometric model describing the sport result. The study group (n = 30) consisted of athletes (aged 19.38 ±0.84) competing in powerlifting. Two methods for collecting information were used: observation and a diagnostic survey. Analytical methods comprised the multiple regression and Hellwig’s method. An analysis revealed that the …

The Imaginal Lexicon Of Aging Studies, William Ebenstein

Publications and Research

Aging Studies focuses on the cultural, humanistic and experiential aspects of aging insofar as these are already embedded in literature, art, language and everyday life. The lexicon of this multi-disciplinary field has evolved in response to shifts in cultural attitudes, social roles, and conceptual frameworks. At the same time, many age-related words have links to poetic imagery and ancient myths, and to evocative etymologies that conjure an historical context. The article looks at the ongoing and surprisingly difficult effort to find the right word to call an older person. It reviews the language and literary genres associated with longevity. And, …

A Cluster Analytic Approach To Examining The Role Of Cortisol In The Development Of Post-Traumatic Stress And Dysphoria In Adult Traumatic Injury Survivors, Devi Jayan, Terri A Deroon-Cassini, Garrett Sauber, Cecilia J. Hillard, Jacklynn M. Fitzgerald

Psychology Faculty Research and Publications

Identification of specific risk factors for posttraumatic stress disorder (PTSD) versus depression after trauma has been challenging, in part due to the high comorbidity of these disorders. As exposure to trauma triggers activation of the hypothalamic-pituitary-adrenal (HPA)-axis, examining atypical stress responses via HPA-axis hormones, namely cortisol, may help in the delineation of these disorders. Indeed, extant research demonstrates that, following stress, individuals with chronic PTSD exhibit hypocortisolism (e.g., lower cortisol response than controls), while those with chronic depression exhibit hypercortisolism (e.g., higher response than controls). Less is known about the role of cortisol and these seemingly disparate profiles immediately following …

Social Disorganization And Violent Crime Across Nonmetropolitan Areas Of Kentucky., Daniel Ray Jude

Electronic Theses and Dissertations

This macro-level study examines the effects of social disorganization predictors on violent crime registered in nonmetropolitan areas of Kentucky from 2012 to 2016. The study intends to expand the line of research interested in verifying the applicability of the social disorganization theory (Shaw & McKay, 1942), including its new theoretical developments, to non-urban settings and plans to contribute to the literature willing to provide a better understanding of violent crime in rural areas. In response to Narag et al.’s (2009) call for a theoretical integration of environmental contaminants among the ecological factors that influence variations in crime, the study also …

Acute White Matter Integrity Post-Trauma And Prospective Posttraumatic Stress Disorder Symptoms, Carissa N. Weis, Ashley A. Huggins, Tara A. Miskovich, Jacklynn M. Fitzgerald, Kenneth P. Bennett, Jessica L. Krukowski, E. Kate Webb, Terri A Deroon-Cassini, Christine L. Larson

Psychology Faculty Research and Publications

Background: Little is known about what distinguishes those who are resilient after trauma from those at risk for developing posttraumatic stress disorder (PTSD). Previous work indicates white matter integrity may be a useful biomarker in predicting PTSD. Research has shown changes in the integrity of three white matter tracts—the cingulum bundle, corpus callosum (CC), and uncinate fasciculus (UNC)—in the aftermath of trauma relate to PTSD symptoms. However, few have examined the predictive utility of white matter integrity in the acute aftermath of trauma to predict prospective PTSD symptom severity in a mixed traumatic injury sample.

Method: Thus, the current study …

Systematics Of Eastern North American Podothrombium (Parasitengona: Podothrombiidae), Kelsey Lynn Cline

Graduate Theses and Dissertations

Velvet mites of the genus Podothrombium Berlese, 1910 are found worldwide with only two described species known from North America, both occurring on the west coast. The present study describes five new species occurring in the east, from both larval and post-larval stages. Species hypotheses are supported with morphology and analysis of mitochondrial (barcoding region of COI) and nuclear genes (D2-3 expansion regions of 28S rDNA). Specimens are incorporated from the Barcode of Life Data Systems (BOLD), allowing our dataset to span most of North America. Therefore, we were able to raise the number of Podothrombium in North America from …

The Impact Of Global Crises On Women: The Case Of Covid-19 In Egypt, Nour A. Dokhan

Theses and Dissertations

Any global crisis is expected to affect every human being, but for women it is always twice as hard. In the case of Covid-19, women are more affected across every domain, from social protection to health, simply because if their gender. This research explores the impact of Covid-19 on women, both economically and socially, with the focus on the case of Egypt. It explores the systematic gender inequalities in the economic, social, and health spheres using cases from previous crises, and how this gender inequality and vulnerability has resulted in much worse consequences of Covid-19 than that of men. The …

Homosexuality And Adoption Of Children: A Bibliometric Analysis, Karthiayani A. Ms., Manika Kamthan Dr.

Library Philosophy and Practice (e-journal)

This study is based on the bibliometric analysis of research publications that focus on highlighting the impact of homosexuality on the process of adoption of children. The primary objective of this study is to analyze the frequency of publications focusing on the impact of parental sexual orientation on the process of adoption in different countries. The data required for this study was collected from the Scopus database and was analyzed using VOSviewer software. Literature published from 2000 to January 2021 were extracted and analyzed. A total of 284 documents which are classified into articles, letters, editorials, conference papers, and reviews …