Digital Commons Network^™

Retinoic Acid-Mediated Inhibition Of Mouse Coronavirus Replication Is Dependent On Irf3 And Camkk, Justin H. Franco, Ryan A. Harris, William G. Ryan, Roger Travis Taylor, Robert E. Mccullumsmith, Saurabh Chattopadhyay, Zhixing K. Pan

Markey Cancer Center Faculty Publications

The ongoing COVID-19 pandemic has revealed the shortfalls in our understanding of how to treat coronavirus infections. With almost 7 million case fatalities of COVID-19 globally, the catalog of FDA-approved antiviral therapeutics is limited compared to other medications, such as antibiotics. All-trans retinoic acid (RA), or activated vitamin A, has been studied as a potential therapeutic against coronavirus infection because of its antiviral properties. Due to its impact on different signaling pathways, RA’s mechanism of action during coronavirus infection has not been thoroughly described. To determine RA’s mechanism of action, we examined its effect against a mouse coronavirus, mouse hepatitis …

Identification En Laboratoire Des Éléments Essentiels Au Processus D’Intégration Sécuritaire De Cellules Cobotiques, Sabrina Jocelyn, Élise Ledoux, Damien Burlet-Vienney, Isabelle Berger, Isvieysys Armas Marrero, Chun Hong Law, Yuvin Chinniah, Abdallah Ben Mosbah, Ilian A. Bonev, Denys Denis, Laurent Giraud

Rapports de recherche scientifique

Les cobots sont apparus vers 2010 en industrie et les accidents sont très peu documentés. La gestion des risques en cobotique représente un réel défi. La littérature scientifique montre l’existence de divers modèles, méthodes et outils pour gérer les risques en cobotique, en mettant l’opérateur humain au cœur de l’intégration des applications collaboratives. Cependant, un autre humain clé de la mise en œuvre de ces applications est négligé la plupart du temps. Il s’agit de l’intégrateur, celui qui doit concevoir la cellule cobotique. À notre connaissance, deux études portant sur un même projet de conception d’un logiciel aidant à mettre …

Safe Sleep Education For Local Refugee And Immigrant Populations, Sara Jones

Posters

Provide Safe Sleep education to local refugee and immigrant populations through their resettlement agency Jewish Vocational Services (JVS) with resources available in their first language.

Himalayan Health Exchange: Kargiakh Medical Expedition, Rachel Oldfather

Posters

Medical expedition to remote Himalayan villages involving high-altitude treks, improvised clinics, and immersion in the local Buddhist culture.

Global Health Elective - Philippines, Hannah Ho

Posters

Provides an overview of experiences working in the Philippines as a pediatric resident.

Healthcare In Under-Resourced Areas, Gabrielle Fleming, Ryan Northup, Bill Houseworth, Lori Housworth

Posters

Describes pediatric resident's experience working in the inpatient unit, ER, PICU, and NICU in Cambodia.

A Case Study Of Hospital Contraceptive Waste Management Practices In Chukwuemeka Odumegwu Ojukwu University Teaching Hospital, Awka, Anambra State, Yanmeer S. Tyotswam, Rosebella Iseme, Eliphas G. Makunyi

Population Health, East Africa

Background: Effective management of hospital waste is a critical component of a hospital’s infection control program and is central to occupational safety for healthcare workers. Thus, this study focused on the assessment of hospital contraceptive waste management practices at Chukwuemeka Odumegwu Ojukwu University Teaching Hospital (COOUTH) Awka, Anambra state, Nigeria.

Methods: A cross sectional analytical study was carried out among healthcare workers selected using multistage sampling technique in 6 categories of healthcare workers in COOUTH. Data was collected using a pre-tested semi-structured interviewer-administered questionnaire and a World Health Organization (WHO) checklist and analyzed using statistical package for the …

Grading Of Malnutrition Among Under 5 Children Residing In Urban Slum In Mysuru Using Who Classification And Indian Academy Of Pediatrics (Iap) Classification: A Comparative Study, Ravali Annaram Dr, Amogha Shree Dr, Saurish Hegde Dr, Krishnaveni Y S Dr

Digital Journal of Clinical Medicine

Background

Malnutrition in Indian children under five is widespread, driven by insufficient food intake and diseases like diarrhoea and respiratory infections. Factors such as food security, maternal literacy, and healthcare access influence malnutrition rates. Growth monitoring utilizes WHO standards globally and IAP guidelines in India. Implementing these charts improves early identification and management of malnutrition, crucial for addressing childhood health challenges in India. This study compare the prevalence of malnutrition in WHO classification with Indian Academy of Paediatrics (IAP) classification among under 5 children residing in urban slum.

Methodology

A community based cross-sectional study was conducted among children aged 6 …

Steps Towards Operationalizing One Health Approaches, Kim M. Pepin, Keith M. Carlisle, Dean Anderson, Michael G. Baker, Richard B. Chipman, Jackie Benschop, Nigel P. French, Suzie Greenhalgh, Scott Mcdougall, Petra Muellner, Emil Murphy, Dion R. J. Neale, Michael J. Plank, David T. S. Hayman

United States Department of Agriculture Wildlife Services: Staff Publications

One Health recognizes the health of humans, agriculture, wildlife, and the environment are interrelated. The concept has been embraced by international health and environmental authorities such as WHO, WOAH, FAO, and UNEP, but One Health approaches have been more practiced by researchers than national or international authorities. To identify priorities for operationalizing One Health beyond research contexts, we conducted 41 semi-structured interviews with professionals across One Health sectors (public health, environment, agriculture, wildlife) and institutional contexts, who focus on national-scale and international applications. We identify important challenges, solutions, and priorities for delivering the One Health agenda through government action. Participants …

Overcoming The Unseen: Understanding Diverse Canadian Workers’ Well-Being During The Beginning Of The Coronavirus Pandemic, Tyler M. Pacheco

Theses and Dissertations (Comprehensive)

Canadian workers were severely affected by the onset of the coronavirus (COVID-19) pandemic. The rapid spread of the pathogen across Canada resulted in several work-related consequences (e.g., temporary/indefinite layoffs and business closures, mandatory working-from-home) that could have impacted workers’ well-being during this turbulent period. Research available at the start of this dissertation process, and even more recently published studies, primarily explored general trends in workers’ negative well-being during COVID-19, not examining the distinct realities that diverse workers, including more marginalized ones, may have experienced. Across three manuscripts, several theories from diverse disciplines (positive, developmental, community, and industrial-organizational psychology, public health) …

Body-Map Storytelling: A Qualitative Exploration Of The Lived Experiences Of Hospital Care Amongst Street Involved Youth, Chelsey Fedchenko

Theses and Dissertations (Comprehensive)

This social work study explores the experiences of hospital care amongst street-involved (SI) youth. Given that SI youth are at a higher risk for health-related harms and experience significant barriers to health care services, they are at an increased likelihood of hospitalization. Yet, inadequate health care support for SI youth remains a critical problem in Canada. While hospital care amongst adult homeless populations has been well studied interdisciplinary, there is a scarcity of research investigating the hospital care experiences amongst SI youth. The aim of this qualitative, arts-based study was to explore how street-life contributes to hospitalization, how SI youth …

Assessing The Value And Knowledge Gains From An Online Tick Identification And Tick-Borne Disease Management Course For The Southeastern United States, Catherine A. Lippi, Holly D. Gaff, Alexis L. White, Sadie J. Ryan

Biological Sciences Faculty Publications

Background

Tick-borne diseases are a growing public health threat in the United States. Despite the prevalence and rising burden of tick-borne diseases, there are major gaps in baseline knowledge and surveillance efforts for tick vectors, even among vector control districts and public health agencies. To address this issue, an online tick training course (OTTC) was developed through the Southeastern Center of Excellence in Vector-Borne Diseases (SECOEVBD) to provide a comprehensive knowledge base on ticks, tick-borne diseases, and their management.

Methods

The OTTC consisted of training modules covering topics including tick biology, tick identification, tick-borne diseases, and public health, personal tick …

Ai And Ml-Based Risk Assessment Of Chemicals: Predicting Carcinogenic Risk From Chemical-Induced Genomic Instability, Ajay Vikram Singh, Preeti Bhardwaj, Peter Laux, Prachi Pradeep, Madleen Busse, Andreas Luch, Akihiko Hirose, Christopher J. Osgood, Michael W. Stacey

Biological Sciences Faculty Publications

Chemical risk assessment plays a pivotal role in safeguarding public health and environmental safety by evaluating the potential hazards and risks associated with chemical exposures. In recent years, the convergence of artificial intelligence (AI), machine learning (ML), and omics technologies has revolutionized the field of chemical risk assessment, offering new insights into toxicity mechanisms, predictive modeling, and risk management strategies. This perspective review explores the synergistic potential of AI/ML and omics in deciphering clastogen-induced genomic instability for carcinogenic risk prediction. We provide an overview of key findings, challenges, and opportunities in integrating AI/ML and omics technologies for chemical risk assessment, …

Use Of Machine Learning Approaches To Predict Transition Of Retention In Care Among People Living With Hiv In South Carolina: A Real-World Data Study, Ruilie Cai, Xueying Yang Ph.D., Yunqing Ma, Hao H. Zhang, Bankole Olatosi Ph.D., Sharon Weissman, Xiaoming Li Ph.D., Jiajia Zhang Ph.D.

Faculty Publications

Maintaining retention in care (RIC) for people living with HIV (PLWH) helps achieve viral suppression and reduce onward transmission. This study aims to identify the best machine learning model that predicts the RIC transition over time. Extracting from the enhanced HIV/AIDS reporting system, this study included 9765 PLWH from 2005 to 2020 in South Carolina. Transition of RIC was defined as the change of RIC status in each two–year time window. We applied seven classifiers, such as Random Forest, Support Vector Machine, eXtreme Gradient Boosting and Long–short–term memory, for each lagged response to predict the subsequent year's RIC transition. Classification …

Improving Dental Students' Knowledge And Confidence In Treating Tobacco Use, Victoria Pierce

DNP Projects

Background: Tobacco use can lead to numerous chronic health conditions. Healthcare professionals in the dental field are in a unique position to broach this issue with patients. Research shows that dental students do not feel equipped to provide tobacco cessation care, citing lack of education on the subject among their top reasons for this.

Purpose: The purpose of this project was to evaluate changes in dental students’ knowledge and confidence related to treating tobacco use after participation in an educational intervention about the 5A’s, behavioral counseling, and first-line prescription medications.

Methods: This quality improvement initiative utilized a quasi-experimental survey design …

Provider And Staff Education Surrounding Universal Hcv Screening And Linkage To Care In An Ambulatory Care Setting, Lauren Clifford

DNP Projects

Abstract

Background: In the United States, it is estimated that there are more than 2 million cases of Hepatitis C (HCV), with over 66,000 new cases since 2020 However, an estimated 75% of those with HCV go undiagnosed and less than 35% receive treatment within a year of diagnosis. In 2018, UK Healthcare (UKHC) implemented a universal HCV screening method using a Best Practice Advisory (BPA) for anyone 18 and older who presented to the Emergency Department and had labs ordered. Patients who screened positive were then referred to outpatient clinics for HCV treatment. Approximately ten percent of positive patients …

Medicaid Managed Care Restrictions On Medications For The Treatment Of Opioid Use Disorder, Maureen T. Stewart, Christina M. Andrews Ph.D., Sage R. Feltus, Dominic Hodgkin, Constance M. Horgan, Cindy Parks Thomas, Thuong Nong

Faculty Publications

Objective: To examine whether Medicaid managed care plan (MCP) utilization management policies for buprenorphine–naloxone and injectable naltrexone are related to key state Medicaid program policy decisions. Data Sources and Study Setting: We abstracted data on state Medicaid regulatory and policy information from publicly available sources and publicly available insurance benefit documentation from all 241 Medicaid MCPs operating in 2021. Study Design: In this cross-sectional study, we used bivariate and multivariate analyses to examine whether Medicaid MCP prior authorization and quantity limits on receipt of buprenorphine and injectable naltrexone were associated with key state Medicaid choices to leverage federal funds to …

Human Mobility And The Infectious Disease Transmission: A Systematic Review, M. Naser Lessani, Zhenlong Li, Fengrui Jing, Shan Qiao Ph.D., Jiajia Zhang Ph.D., Bankole Olatosi Ph.D., Xiaoming Li Ph.D.

Faculty Publications

Recent decades have witnessed several infectious disease outbreaks, including the coronavirus disease (COVID-19) pandemic, which had catastrophic impacts on societies around the globe. At the same time, the twenty-first century has experienced an unprecedented era of technological development and demographic changes: exploding population growth, increased airline flights, and increased rural-to-urban migration, with an estimated 281 million international migrants worldwide in 2020, despite COVID-19 movement restrictions. In this review, we synthesized 195 research articles that examined the association between human movement and infectious disease outbreaks to understand the extent to which human mobility has increased the risk of infectious disease outbreaks. …

Le Travail Dans Les Espaces Ouverts Et De Coworking : Deux Études En Ergonomie De L'Activité, Marlène Cheyrouze, Diane-Gabrielle Tremblay

Rapports de recherche scientifique

Ce rapport s'inscrit dans le cadre du projet intitulé : Les caractéristiques des espaces ouverts et des espaces de coworking en lien avec la SST (no 2018-0030), sous la direction de la professeure Diane-Gabrielle Tremblay, université TÉLUQ. L’étude en ergonomie de l’activité propose une analyse du travail en espaces ouverts et de coworking. Ces derniers sont présentés comme des lieux propices aux interactions sociales spontanées. Elles sont facilitées par l’aire ouverte qui, induisant le partage des locaux et du mobilier, instaure une coprésence et une proximité physiques entre les personnes. Mais ces interactions peuvent être vécues comme des distractions …

Recherche-Action Visant Le Développement D'Un Modèle D'Intervention Préventive En Sst Par Et Pour Les Préposés Aux Bénéficiaires En Chsld, Nathalie Jauvin, François Aubry, Francis Etheridge, Isabelle Feillou, Éric Gagnon, Andrew Freeman, Nancy Côté, Caroline Biron, Mariève Pelletier, Saliha Ziam, Manon Truchon

Rapports de recherche scientifique

Contexte

Ce rapport a pour objectif de présenter les résultats d’une recherche-action visant le développement d’un modèle d’intervention préventive en santé et sécurité du travail (SST) par et pour les préposés aux bénéficiaires (PAB) dans les centres d’hébergement et de soins de longue durée (CHSLD) du Québec. Les PAB sont au coeur des soins prodigués dans les milieux gériatriques. Malheureusement, l’augmentation du nombre de blessures et l’accentuation des problématiques de santé psychologique subies par ce personnel depuis quelques années fragilisent leur situation, ce qui se prouve en termes de faible rétention et de fort absentéisme chronique de ce personnel. Ce …

Validation Du Questionnaire Pour Le Dépistage De L'Asthme Relié Au Travail (Qdart(L)Tm) Pour L'Amélioration De Sa Détection Précoce, Catherine Lemiere, Diane Lougheed, Teresa To, Lucie Blais, Brian White-Guay

Rapports de recherche scientifique

L’asthme est une maladie qui touche environ 9 % de la population canadienne. Vingt pour cent des cas d’asthme sont aggravés par l’environnement de travail. On appelle cette condition l’asthme relié au travail (ART). Cependant, les cas d’ART sont souvent sous-diagnostiqués. Le diagnostic d’ART repose fréquemment sur la mise en évidence de l’aggravation des symptômes d’asthme en milieu de travail, cependant un diagnostic objectif d’ART repose sur la mise en évidence de changement de la fonction respiratoire durant les périodes en milieu de travail par rapport à des périodes hors travail. Nous avons développé un nouveau questionnaire : Questionnaire pour …

Opérationnaliser L'Approche De L'Entretien Motivationnel Pour La Réadaptation Au Travail, Marie-France Coutu, Marie-José Durand, Marie-Élise Labrecque, Sara Pettigrew

Rapports de recherche scientifique

Chaque année, de nombreux travailleurs ont de la difficulté à retourner au travail en raison d'une incapacité. L’incapacité au travail due à un problème de santé, lorsqu’elle persiste dans le temps, a des répercussions importantes pour les travailleurs, mais aussi pour leurs employeurs. Bien qu’il existe des interventions reconnues efficaces pour favoriser la reprise du travail, une des barrières est liée à la capacité du clinicien à établir une relation soutenante avec la personne en absence. Il existe une approche de communication qui soutient la relation, mais celle-ci est encore peu implantée dans la pratique courante en réadaptation.

L’objectif général …

Impact Des Efforts Physiques En Milieu De Travail Sur Le Développement De La Fatigue Musculaire, Les Propriétés Tissulaires Et La Stabilité Posturale Des Travailleurs Plus Âgés : Une Étude De Faisabilité (Version Corrigée), Martin Descarreaux, Abboud Jacques, Vincent Cantin, Stéphane Sobczak, Pierre-Yves Therriault

Rapports de recherche scientifique

Problématique de santé et de sécurité du travail et objectifs

Le prolongement de la vie active représente un phénomène croissant chez les travailleurs québécois de plus de 55 ans. En 2017, ce groupe représentait près de 20 % des travailleurs occupant un emploi à temps plein. Considérant les changements physiologiques qui s’opèrent avec le vieillissement, l’emploi de travailleurs plus âgés peut nécessiter l’adaptation des tâches en tenant compte de leur capacité physique et de leurs limites de manière à préserver leur santé. Bien que peu de données soient actuellement disponibles, il est probable que les efforts physiques et les contraintes …

A History Of Cioms (Council For International Organizations Of Medical Sciences) And The Creation Of Multinational Consensus For Human Subjects Research Ethics, Abigail Belle Cheung

Public Health Theses

N/A

“How Long On Top Of The Hill?”: The Legacy Of Community Mental Health Programs, Institutionalized Relationships, And The Stifling Of Black Power (New Haven, 1963-1971), Sophie Elizabeth Edelstein

Public Health Theses

In the early 1960s, the Community Mental Health Centers Act aimed to overhaul the infrastructure of the mental health care system, transitioning patient care from dilapidated state psychiatric institutions to self-sufficient, comprehensive mental health centers within communities. Many academic medical centers viewed this federal legislation as an opportunity to gain access to an additional patient population for training and economic purposes. From New York City to Boston to New Haven, institutional aspirations for community control were burgeoning, and community psychiatry became a conduit for institutions to extend their reach into local communities under the guise of progressive mental health reform. …

Examining Factors Associated With Covid-19 Disruptions To Tuberculosis Services, Tejaswini Dharmapuri Vachaspathi

Public Health Theses

Background: The COVID-19 pandemic posed unprecedented challenges to global health systems, significantly impacting the delivery of essential health services, including tuberculosis (TB) care. It is important to analyze the factors associated with the reductions in TB notifications during the pandemic, with a focus on high TB burden countries, to inform strategies for making TB programs more resilient to health system shocks.

Methods: Amongst 98 selected high-burden countries, a GLM analysis was employed to examine the association between ‘missed’ TB case notifications from 2020 to 2021, and various country-level factors including: COVID-19 mortality estimates, lockdown stringency index, GDP per capita, health …

Bmi's Early Echo: Deciphering Adolescent Body Mass Indicator On Adulthood Breast Cancer, Tianyu Feng

Public Health Theses

This study aimed to explore the association between body mass index (BMI) during adolescence and the risk of breast cancer in adulthood among a Chinese female population. We conducted a nested case-control study within a prospective cohort comprising 62,487 Chinese women aged 25-55 years. Adolescent BMI was retrospectively collected via interviewer-administered questionnaires and analyzed as the primary exposure variable. Breast cancer incidence served as the primary outcome. Propensity Score Matching (PSM) was employed to adjust for confounding variables, such as socioeconomic status, lifestyle factors, and adult BMI.Of the 9,163 participants eligible for analysis, 57 breast cancer cases were identified during …

Exploring The Associations Between Stereotypes Of Aging And Dementia And Self-Reported Health In Parent-Adult Child Dyads, Yunke Gu

Public Health Theses

Stereotypes and stigma about Alzheimer’s Disease continue to emerge, as the number of populations affected by the disease in society is escalating. The sociocultural context sets the stage for the significant impact that Alzheimer’s has on family dynamics, especially for the adult children who provide over half of informal caregiving. Our study aims to adopt a dyadic approach, examining the interrelated experiences of adult child caregivers and their parents with ADRD. 126 dyads were included in this secondary data analysis. Measures included depressive symptoms and self-reported physical and mental health, stereotypes of aging and of person with memory loss. Results …

A Geospatial Review Of Covid-19 Testing Sites In Kentucky, Jose Marco Hernandez

Public Health Theses

The COVID-19 pandemic has accentuated healthcare access disparities, especially impacting underserved rural and urban areas. This paper investigates the accessibility of COVID-19 testing centers across Kentucky, focusing on spatial and demographic disparities. Using geospatial techniques, the study comprehensively examines testing site distribution and accessibility challenges to inform strategies addressing healthcare disparities. Adopting an observational cross-sectional design, the study utilizes 2020 US Census tract data to assess testing center accessibility in Kentucky's 120 counties. Geospatial analysis, including GIS techniques, maps testing center distribution, evaluates travel time, and examines demographic influences. Statistical tests explore associations between socio-economic factors and testing accessibility. Findings …

Comparing Hpv Vaccination Uptake In Democrat And Republican Us States Using Presidential Elections Voting Patterns In 2016 And 2020, Omar Guerrero

Public Health Theses

Abstract Objective: To investigate the association between state-level voting patterns and Human Papillomavirus (HPV) vaccination coverage in teenagers in the US. Methods: States were categorized as either Democratic or Republican based on the 2016 and 2020 Presidential election results. A paired t-test was conducted to examine the difference between vaccination coverage between the two groups. A multivariable linear regression model was conducted to examine how state-voting patterns are associated with HPV vaccination coverage after adjusting for confounding (percentage of people living in poverty, percentage of uninsured people, percentage of non-white population, and the percentage of people living in rural areas …