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Back Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Commencement Program 1981 (Summer Conferring Of Degrees), Loma Linda University

Commencement Programs

CONTENTS

3 | The Academic Procession

4 | Conferring of Degrees

6 | Candidates for Degrees

14 | Awards

Health Care Expenditures In Maine 1978 : A Funds Flow Analysis, Bruce Armstrong

Maine Collection

Health Care Expenditures in Maine 1978 : A Funds Flow Analysis

by Bruce Armstrong, Research Consultant

Maine Department of Human Services, Bureau of Health Planning and Development, Division of Data and Research, Augusta, Maine (August 1981).

Contents: Preface / Highlights / List of Tables and Figures / Introduction / Definitions / Health Expenditures / Sources of Funds / Type of Expenditure / Comparison of Maine and U.S. Per Capita Expenditures

Trends In Health Care Expenditures, Maine 1974-1978, Bruce Armstrong

Maine Collection

Trends in Health Care Expenditures, Maine 1974-1978

by Bruce Armstrong, Research Consultant

Maine Department of Human Services, Bureau of Health Planning and Development, Division of Data and Research, Augusta, Maine (August 1981).

Contents: Preface / Highlights / List of Tables and Figures / Yearly Tables / Trend Illustrations and Tabular Descriptions

Commencement Program 1981 (School Of Health Extended Programs), Loma Linda University

Commencement Programs

CONTENTS

2 | Biography of Mervyn G. Hardinge

4 | Recognition of Candidates

6 | Candidates

8 | Department History and Development

The Epidural Defect On Myelography: Some Unusual Causes, Keenan L. Carroll

Henry Ford Hospital Medical Journal

This report describes four cases of epidural defect found on myelography that illustrate some unusual causes of this defect. These include a type I chondrosarcoma, primary hemangioendothelioma, hematoma, and an epidural abscess. Surgery was performed, and all four patients have recovered with little or no remaining neurological deficit. If there is anything unusual about the epidural defect or if the clinical findings do not agree with the radiographic films, the radiologist should be alert for other, less common causes of the defect.

Second-Year Follow-Up Study On Systematic Treatment Of Chronic Pain With Antidepressants, Dietrich Blumer, Mary Heilbronn

Henry Ford Hospital Medical Journal

Systematic therapy with antidepressant drugs can be an effective treatment for chronic pain patients with the pain-prone disorder. This survey follows the pain status, medications, depressive symptoms, work status, and treatment of 104 patients treated for chronic pain at Henry Ford Hospital's Pain Clinic during a two-year period for chronic pain in the absence of a significant somatic disorder. No patients were excluded from treatment and the dropout rate of 64% after two years was not surprising. The pain of those who complied with therapy improved significantly (62%), compared to that of the patients who had dropped out of the …

Combining Provocative Agents Of Calcitonin To Detect Medullary Carcinoma Of The Thyroid, J. C. Sisson, M. D. Gross, J. E. Frietas, C. E. Jackson, B. G. England

Henry Ford Hospital Medical Journal

The presence of clinically undetectable medullary thyroid cancer can be revealed by characterisdc patterns of calcitonin in serum after the injection of a provocative agent, pentagastrin or calcium ion. However, in some reports, medullary thyroid cancer was uncovered in a test with pentagastrin but not in one with calcium ion, and vice versa. To reduce the number of erroneous responses, each provocative agent has been employed in separate tests. Combining pentagastrin and calcium into one stimulus should give the advantage of each agent while requiring less time and fewer analyses in a single test. We combined pentagastrin injection and calcium …

1980 Publications Of The Staff Of Henry Ford Hospital

Henry Ford Hospital Medical Journal

No abstract provided.

Back Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Front Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Henry Ford Hospital: Options And Opportunities In The 1980s, Douglas S. Peters, Bruce W. Steinhauer

Henry Ford Hospital Medical Journal

This presentation by Mr. Peters and Dr. Steinhauer was given before the Henry Ford Hospital Professional Staff at a semi-annual dinner and staff meeting held on Tuesday, May 6, 1980. It offers a timely assessment of the position and prospects of the Hospital as we enter the new decade. On occasion, the journal features nontechnical articles like this presentation that we believe are of general interest to our readers.

Surgical Management Of Multicentricity, Nipple-Areola Involvement, And Bilaterality In Breast Carcinoma, F. Samhouri, M. Block, A. Kambouris

Henry Ford Hospital Medical Journal

During a five-year period, 457 women who underwent partial, segmental, or total mastectomy were assessed for multicentricity (31%), nipple-areola involvement (17%), and bilateral breast carcinoma (9%). These factors determined the extent of surgery performed and the possibilities for later breast reconstruction. The frequency of nipple-areola involvement in breast cancer strongly indicates the need for alternatives to their preservation for breast reconstruction. The study concludes that total mastectomy for invasive carcinoma is the preferred method of treatment for early breast cancer until further clinical trials have assessed the value of segmentectomy.

Preliminary Experience With Endoscopic Papillotomy, Bernard Schuman

Henry Ford Hospital Medical Journal

Endoscopic papillotomy is a non-operadve technique used to manage choledocholithiasis and papillary stenosis. Considerable experience in Europe and initial results in a few medical centers in the United States indicate that it is effective and safe. Six papillotomy procedures were performed at Henry Ford Hospital without complication, and with a successful outcome in five. Endoscopic papillotomy is the procedure of choice for retained common bile duct stones less than 2 cm in diameter.

Acute And Massive Intraparenchymal Hemorrhages Of The Posterior Fossa, Dennis E. Wilkins

Henry Ford Hospital Medical Journal

Acute, massive cerebellar and pontine hemorrhages are discussed in the context of the routine availability of cranial computerized tomography. The diagnosis of these disorders is emphasized. An updated clinical review of the edologic, pathogenetic, and therapeutic aspects is also presented, with particular attention to the importance of hypertensive cerebrovascular disease as the most common underlying disorder.

Prenatal Diagnosis Of Fetal Cystic Hygromas Associated With Generalized Lymphangiectasis, Chang Y. Lee, Beatrice L. Madrazo, Daniel L. Van Dyke, Jewel Smith

Henry Ford Hospital Medical Journal

Ultrasonography has made possible the prenatal diagnosis of many congenital fetal abnormalities. This report describes two cases of bilateral cystic hygromas of the neck associated with generalized lymphangiectasis that were diagnosed by ultrasound. Ultrasonic scans revealed moderate polyhydramnios: thick, edematous placenta and edematous fetus with large cystic mass occupying both sides of the neck and extending to the upper chest wall, ascites, and pleural effusion at gestational ages of 21.5 and 24 weeks, respectively. In one case, chromosomal study from amniotic fluid cell culture revealed X chromosome monosomy, often associated with lymphatic anomalies. The prenatal diagnosis was confirmed at birth: …

Dysfunction Of Mitral Ball Valve Prosthesis, M. R. S. Nair, Wolf F. C. Duvernoy, Daniel T. Anbe, Eldred G. Zobl, Agustin Arbulu

Henry Ford Hospital Medical Journal

Three case histories of patients with malfunctions of Smeloff-Cutter mitral ball valve prostheses are presented here - one underwent successful replacement. The clinical diagnosis was made by observing a marked variation in the A2OC interval and intermittent absence of the opening click. Phonocardiograms were diagnostic in all three cases. while echocardiograms and even angiograms did not uniformly diagnose prosthetic valve dysfunction. Periodic phonocardiographic evaluations may be helpful in early detection of the prosthetic valve dysfunction. Once the diagnosis is established, immediate surgical treatment is imperative to prevent sudden death.

Clinical Thermoradiotherapy, H. I. Bicher, T. S. Sandhu, F. W. Hetzel

Henry Ford Hospital Medical Journal

A clinical trial is currently in progress to determine the efficacy of combined fractions of hyperthermia and radiation. The protocol consists of two parts. First, four fractions of microwave-induced hyperthermia (45.0° ± 0.5°C) are applied for 1 1/2 hours to the volume encompassing the tumor, each separated by 72 hours. After a one-week rest, a second series of four fractions is administered again at 72- hour intervals. Each fraction consists of a 400 rad dose of radiation followed within 20 minutes by hyperthermia (42.5 ± 0.5°C) for 1 1/2 hours. Currently, we have treated 62 patients with 82 fields with …

Back Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Clinical Hyperthermia And Irradiation: Pilot Studies, John Fazekas, Ted Nerlinger

Henry Ford Hospital Medical Journal

Phase / (February 1979-May 1980) of our hyperthermia pilot study involved 26 carcinoma patients who participated in two treatment protocols: 20 patients received electron beam x-ray therapy plus an average of eight hyperthermia sessions (twice weekly at 42.5°-43.5°C intralesional temperatures for 40 minutes); 17 patients were heated with a 3450 microwave MHz generator in conjunction with surface heating (circulating water bag at 45°C). AGA thermograms assessed superficial blood flow to document heating patterns and forewarned of potential overheating as manifested by superficial burns (blisters). Although our study Is nonrandomized and our patient numbers are small, we noted a complete response …

Local Hyperthermia And Radiation: A Biologically-Oriented Clinical Scheduling, G. Arcangeli, A. Cividalli

Henry Ford Hospital Medical Journal

In a series of animal tumor studies, heat was directly delivered into the tumor mass with an interstitial applicator. After hyperthermia (44°-45°C for 45 minutes) or radiation alone (3x10 Gy), only a slight delay in tumor growth was observed, while the combined treatment, either simultaneous or sequential (i.e., heat delivered four hours after irradiation), appeared to be the most effective. The cure rate in the two combined treatment groups was 100%, in contrast to the lack of cure in the first two groups. The simultaneous use of heat and x-ray appeared to be slightly more effective than the sequential schedule; …

Glucose Metabolism In Mouse Tumor And Liver With And Without Hyperthermia, Christian Streffer, Siegelinde Hengstebeck, Peter Tamulevicius

Henry Ford Hospital Medical Journal

We measured levels of glycolytic metabolites in mouse tumor and liver after administering a glucose load of 6 mg/g of body weight and after hyperthermia for one hour at 43°C. Metabolites included glucose, glucose-6-phosphate, fructose-1.6-diphosphate, dihydroxyacetone-phosphate, glycerol-3-phosphate, pyruvate, and lactate, as well as acetoacetate and β-hydroxybutyrate. The combined treatment led to an increase of the lactate level and apparently enhanced glucose degradation. The redoxequilibria states were shifted to the reduced metabolites. It is possible that hypoxia was induced or enhanced, which could have significance for tumor therapy. At later periods after hyperthermia, metabolic alterations occurred that have also been observed …

Hyperthermia, F. K. Storm

Henry Ford Hospital Medical Journal

This report describes the history of hyperthermia and reviews current forms of treatment at both low (42°-43°C) and higher (<45°C) temperatures. Hyperthermia treatment at low temperatures includes fluid immersion and irrigation, regional perfusion with heated fluids, and electromagnetic radiofrequency waves. Low-temperature hyperthermia has also been combined with radiation therapy and with chemotherapy in recent clinical trials. At higher temperatures, we and other investigators have also had promising, preliminary results in treating tumors safely. With the specialized radiofrequency instrumentation we have developed to apply hyperthermia at any depth without preferential surface tissue heating, further clinical investigation of both superficial and deep internal solid tumors is now possible. Recent data suggest that hyperthermia may be an especially effective form of therapy for larger tumors that resist standard forms of treatment. Clinical trials are now underway to determine the most therapeutic dose/time regimen, to determine toxicity and therapeutic enhancement ratios of combined chemotherapy and x-irradiation with hyperthermia, and to evaluate any changes in the host immune system with such therapies.

Hyperthermic Perfusion 16 Years After Its First Clinical Applications, R. Cavaliere, G. Moricca, F. Di Filippo, L. Aloe, G. Monticelli, F. S. Sartori

Henry Ford Hospital Medical Journal

It is known that above-normal temperatures (42°-42.5°C) provoke selective damage to neoplastic cells. We used heated circulating blood as a method for heat transfer on patients with limb tumors. From October 1964 to December 1979, we treated a total of 198 patients with hyperthermic perfusion for melanoma of the limbs (91), osteosarcoma (57), and soft tissue sarcoma (50). For melanoma patients, the five-year survival rate, excluding Stage IV, was 60%. For patients with soft tissue sarcoma, the five-year survival rates were 53% and 56% for hyperthermic perfusion and hyperthermic antiblastic perfusion. respectively. For 29 patients with osteosarcoma, hyperthermic perfusion was …

Front Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Local Microwave Hyperthermia In Cancer Therapy: Preliminary Report, Carlos A. Perez, Walter Kopecky, Robert Baglan, D. Venkata Rao, Richard Johnson

Henry Ford Hospital Medical Journal

This report summarizes our preliminary experience at the Mallinckrodt Institute of Radiology treating 26 patients with metastatic tumors with hyperthermia and irradiation. Patients received 400 rad fractions given every 72 hours (twice weekly) for a total of 2400, 2800, 3200, or 4000 rad followed by hyperthermia. In addition, 18 lesions were treated according to a protocol designed by the Radiation Therapy Oncology Group (RTOG) for superficial measurable tumors to receive three doses of 500 rad followed by hyperthermia (six lesions) or irradiation alone (three doses of 600, 700, or 800 rad) every 72 hours. Hyperthermia was administered with 2450 MHz …

Microwave Hyperthermia At 2450 And 915 Megahertz Frequencies, Kenneth H. Luk

Henry Ford Hospital Medical Journal

Microwave hyperthermia at frequencies of 2450 and 915 megahertz (MHz) was used to treat superficial measurable tumors of different histopathologies at various sites. Forty-seven patients received 59 courses of treatment; they were able to tolerate temperatures up to 42.5X1. Although hyperthermia alone (40°-42.5°C) did not produce an effective response, hyperthermia and radiation together (up to 2700 rad in nine fractions over three weeks) produced complete and partial responses in three-fourths of the treatment courses. The combination of hyperthermia and chemotherapy may have great potential, but confirmation of these clinical impressions will depend on a much larger series of patient data. …

Hyperthermia Treatment Of Experimental Tumors, J. Denekamp, S. A. Hill, F. A. Stewart

Henry Ford Hospital Medical Journal

The therapeutic advantage of combining hyperthermia with x-irradiation to treat tumors depends on whether or not it is possible to achieve greater thermal sensitization of tumors than of normal tissues. To determine such therapeutic gain factors (TGE), we assessed the response of mouse skin and seven transplantable mouse tumors to graded x-ray doses given alone or combined with moderate heat (42.5°C for 60 minutes). We constructed dose response curves for the average early skin reaction and for the induced delay in tumor regrowth to an arbitrarily chosen size. We studied the following areas: 1) the therapeutic gain of combining heat …

Namru-3 Translations Of Parasite Literature From Russian, French, Japanese, Etc. Into English (1921-1981) T1401-T1500, United States Naval Medical Research Unit Number Three, Cairo, Medical Zoology Department

United States Naval Medical Research Unit 3: Publications

T1401. TRANSLATION FROM RUSSIAN. L'VOV, D. K., GROMASHEVSKY, V. L., SIDOROVA, G. A., TSIRKIN, Yu. M. CHERVONSKY, V. L. GOSTINSHCHIKOVA, G. V. and ARISTOVA, V. A. (1971). Isolation of a new arbovirus Baku of Kemerovo group from argasid ticks Ornithodoros coniceps. in Azerbaijan. Vop. Virus., 16(4):434-437.

T1402. TRANSLATION FROM RUSSIAN. ALEKSANDROV, Yu. V., KORYAGIN, V. L. and YOVAL'CHUK, Zh. T. (1970). Observations on ecological biological properties of Hyalomma plumbeum ticks in eastern Crimea. Tezisy Dokl. 2. Akarol. Soveshch., (1):22-24.

T1403. TRANSLATION FROM RUSSIAN. MATEVOSYAN, K. Sh., KARASEVA, P. S. and SEMENOV, B. F. (1974). Study of potential arbovirus foci in …

Commencement Program 1981, Loma Linda University

Commencement Programs

CONTENTS

3 | The President's Greeting

4 | 1981 Events of Commencement

5 | The Academic Procession

6 | The Speakers

9 | The Honorees

11 | Order of Programs

• School of Medicine, 12
• Graduate School, 18
• School of Nursing, 22
• School of Dentistry, 25
• School of Education, 31
• College of Arts and Science, 36
• School of Allied Health Professions, 41
• School of Health, 47