Digital Commons Network^™

Primary Hyperparathyroidism And Associated Neoplasms, Angelos A. Kambouris, Mohammed R. Ansari, Gary B. Talpos

Henry Ford Hospital Medical Journal

No abstract provided.

Effects Of Weight Reduction, Exercise, And Diet Modification On Lipids And Apolipoproteins A-L And B In Severely Obese Persons, J. David Fachnie, Craig C. Foreback

Henry Ford Hospital Medical Journal

We assessed the lipid and apolipoprotein effects of hypocaloric dieting, increased physical activity, and dietary modification in severely overweight adults (body mass index [BMI] 43.05 kg/m-). The 34 women and four men enrolled in the ambulatory weight control program donated blood before, during, and after hypocaloric dieting (420 kcal/day). Mean values before dieting included cholesterol of 223 mg/dL, high-density lipoprotein (HDL) cholesterol of 43 mg/dL, and cholesterol/HDL cholesterol of 5.90. This placed our subjects at high risk for coronary artery disease. Other values included triglycerides of 138 mg/dL, apolipoprotein A-l of 152 mg/dL. and apolipoprotein B/apolipoprotein A-l of 0.64. Significant …

Renal Involvement In Type 2 Diabetes Mellitus: A Clinicopathologic Study Of The Henry Ford Hospital Experience, Francis Dumler, Vijay Kumar, Raymond N. Romanski, Pedro Cortes, Nathan W. Levin

Henry Ford Hospital Medical Journal

To better understand renal dysfunction in type 2 diabetes mellitus, we studied the clinical and autopsy findings in comparable cohorts of 108 diabetic and 77 nondiabetic patients. In the diabetic group, no differences were noted between black and white patients in blood glucose concentrations, mean blood pressure, or the prevalence of diabetic glomerulosclerosis. However, the prevalence of renal insufficiency was significantly greater (P = 0.002) in black diabetics (58%) than in white diabetics (35%). black controls (28%), and white controls (20%). Logistic regression analysis demonstrated a significant association of renal insufficiency with diabetes (P = 0.006) and race (P = …

Primary Aldosteronism At Henry Ford Hospital In The 1980s, Max Wisgerhof

Henry Ford Hospital Medical Journal

This report describes the experience with the diagnosis and treatment of primary aldosteronism at Henry Ford Hospital since 1980. Of the 28 patients who received the diagnosis. 13 had unilateral primary aldosteronism and 15 had idiopathic hyperaldosteronism. Individual cases are used to demonstrate clinical points. The clue to the presence of primary aldosteronism in a hypertensive patient is hypokalemia. The diagnosis is established by showing 1) high plasma aldosterone after intravenous saline or high urinary aldosterone after treatment with sodium chloride orally, and 2) low stimulated plasma renin activity. Treatment with potassium supplement should be given during the testing. Unilateral …

Management Of Extramedullary Plasmacytomas, James A. Bonner, Jadranka Dragovic, Michael P. Abrash

Henry Ford Hospital Medical Journal

From 1965 through 1982. 12 patients with solitary, biopsy-proven extramedullary plasmacytomas (EMPs) were treated at our institution with surgery alone or biopsy followed by radiation therapy. The median age of the patients was 67 years, and the median-follow-up was 58 months. Of the seven patients who were treated by primary surgery, three developed recurrent or distant disease. Five patients underwent biopsy followed by radiation therapy, and none of their tumors progressed. Our series and a review of the literature show that occasionally EMPs will incompletely regress even after high doses of radiation (greater than 65 Gy); however, we recommend that …

Unusual Lymphomas Developing In Chronic Lymphocytic Leukemia, Sundara B. K. Raman, Sheikh M. Saeed, Joseph P. Abraham

Henry Ford Hospital Medical Journal

We report three patients with chronic lymphocytic leukemia (CLL) who developed malignant lymphomas of unusual character and modes of presentation. Two of the patients had received low doses of chlorambucil for several years before they developed malignant lymphoma, diffuse, large cell type (LCL). In one of these patients LCL manifested as a grossly evident osteolytic lesion. In the second patient LCL developed initially as a localized lesion in the iliac bone. Both patients died within a few weeks after LCL was diagnosed. The third patient, who was found to have CLL during a routine examination, did not receive any therapy …

T-Cell Lymphoma In Renal Transplant Recipient, Koichi Maeda, Leslie Bricker, Chan K. Ma, Michael J. Deegan

Henry Ford Hospital Medical Journal

A 35-year-old woman, who had a renal transplant flve years ago, developed malignant lymphoma of the mediastinum. The lymphoma was of lymphoblastic type and had T-cell immunophenotype. Most transplant-related lymphomas are of B-cell type. T-cell lymphoma in this setting is extremely rare, and the mechanism of development may be different from that of B-cell lymphomas.

Obstructing Giant Pseudopolyposis Of The Colon In Ulcerative Colitis, Roberta E. Sonnino, Farouck N. Obeid

Henry Ford Hospital Medical Journal

Pseudopolyposis of the colon is a well-recognized local complication of ulcerative colitis. Giant pseudopolyposis is uncommon, and its presentation as a complete obstruction of the colon is a rare occurrence. We report such a case, where retrograde flow of barium on double-contrast barium enema was completely obstructed at midtransverse colon. After resection by total abdominal colectomy, pathology examination ofthe specimen confirmed massive pseudopolyposis without malignancy. A brief review of the pathology and current literature is presented.

Ocular Irrigating Solutions: A Comparison Between Balanced Salt Solution And L-410 (Po-Eis), Philip C. Hessburg, Paul M. Johnston

Henry Ford Hospital Medical Journal

The ability of two ocular irrigating solutions to reduce postoperative corneal edema after intracapsular cataract extraction was compared using ultrasonic pachymetry. All patients had anterior chamber intraocular lenses implanted. The solutions were balanced salt solution and solution L-410 (PO-EIS), an eye irrigation solution containing dextran 40 and bicarbonate. Corneas irrigated with either solution showed no significant difference in postoperative edema. The use of L-410 (as an alternative to balanced salt solution) may not be necessary in intracapsular cataract extraction.

Melvin A. Block, Md, Gary B. Talpos

Henry Ford Hospital Medical Journal

No abstract provided.

Book Review: Guides To Clinical Aspiration Biopsy: Thyroid, John E. Brunner

Henry Ford Hospital Medical Journal

No abstract provided.

The Aids Project Newsletter (November 1987), David Ketchum, The Aids Project

AIDS Project Newsletter (1987-1991)

No abstract provided.

The Effect Of Prospective Payment System On Coding Practices In Kentucky Hospitals, Doris Thayer

Masters Theses & Specialist Projects

The purpose of this study was to identify the effects of the prospective payment system on coding practices, resource allocations, quantitative and quantitative standards and organizational structure in medical record departments of 108 acute care, general medical and surgical hospitals in Kentucky.

The study results revealed changes in coding practices consistent with the demand under the prospective payment system for more timely, complete and accurate information for billing purposes. Additionally, accurate data were needed to establish a reliable case-mix data base upon which future reimbursement formulas would be based. Increases in human and capital resources, especially in the area of …

Ua66/13/3 Newsletter, Wku Health & Safety

WKU Administration Documents

Newsletter created by and about the WKU Health & Safety department.

The Aids Project Newsletter (October 1987), David Ketchum, The Aids Project

AIDS Project Newsletter (1987-1991)

No abstract provided.

Tardive Dyskinesia: A Prevalence Study In An Outpatient Population, Virginia J. Ravizza

Community & Environmental Health Theses & Dissertations

The purpose of this prevalence study was to assess the occurrence of tardive dyskinesia among a chronically mentally ill sample of a suburban mental health clinic. The participants in this study were selected from clients of a suburban mental health clinic who agreed to participate in this prevalence study. There were 45 participants--17 males and 28 females.

The Abnormal Involuntary Movement Scale (AIMS) was selected as the instrument to measure the abnormal involuntary movements exhibited by the participants of the study on the day of testing. The testing occurred during a specific time period, June 8, 1987 to July 2, …

Women And Aids: The Future Is Grim, Mary E. Guinan, Ann Hardy

School of Public Health Faculty Research

Recently, we analyzed the reported cases of acquired immunodeficiency syndrome (AIDS) in women in the United States.1 We found two areas of great concern: first, women are more likely than men to acquire AIDS through heterosexual intercourse, and second, women are the source of disease for about 80% of children with AIDS. In this column we will discuss the source and distribution of AIDS in women, and in a future piece we will discuss women as the source of infection for pediatric AIDS cases.

The Aids Project Newsletter (September 1987), David Ketchum, The Aids Project

AIDS Project Newsletter (1987-1991)

No abstract provided.

Commencement Program 1987 (Summer Conferring Of Degrees), Loma Linda University

Commencement Programs

CONTENTS

3 | The Academic Procession

4 | Conferring of Degrees

6 | Candidates for Degrees

The Aids Project Newsletter (August 1987), David Ketchum, The Aids Project

AIDS Project Newsletter (1987-1991)

No abstract provided.

Effects Of Dietary Calcium Levels On Human Blood Pressures, Janice Mearkle

Masters Theses & Specialist Projects

The prevalence of hypertension in the U.S. and similar industrialized countries continues to rise. Millions of people are affected in America alone. Usual treatment includes a low sodium diet, weight loss if needed, and drug therapy. Some health providers also encourage stress management as an adjunct to therapy. These treatments have been shown to be effective but patient compliance continues to be poor. Past research has explored the relationships between dietary calcium and hypertension and has found that there is an interaction between blood calcium levels and high blood pressure. The research reported here was a test of the relationship …

Thyroid C-Cell Hyperplasia And Micronodules In Close Relatives Of Men-2 A Patients: Pitfalls In Early Diagnosis And Reevaluation Of Criteria For Surgery, Cees J. M. Lips, John R. Leo, Marianne J. H. Berends, Werner H. Minder, A. P. Roeland Blok, Rolf A. Geerdink, Wil H. L. Hackeng, Jan M. M. Roelofs, Hans F. A. Vasen, Jan K. Vette

Henry Ford Hospital Medical Journal

In a large family with multiple endocrine neoplasia rype 2 A (MEN-2 A), 20 patients were identified by the diagnosis of medullary thyroid carcinoma (MTC) and/or pheochromocytomas. Another five subjects had neck surgery on the basis of slightly increased results of a C-cell provocative test. Retrospectively, however, although the immunohistochemical diagnosis of C-cell hyperplasia was confirmed, the diagnosis of MEN-2 was doubtful in these five subjects, and the C-cell hyperplasia observed was probably within the limits of normal variation. The occurrence of C-cell hyperplasia in a normal population was investigated by a C-cell provocative test, as well as in random …

Ua66/4/2 Allied Health Department Newsletter Issue No. 1, Wku Allied Health

WKU Administration Documents

Newsletter created by and about WKU Allied Health.

The Aids Project Newsletter (July 1987), David Ketchum, The Aids Project

AIDS Project Newsletter (1987-1991)

No abstract provided.

Reactions Of Organic N-Chloramines In The Gastric Fluid Of The Rat, Kathryn E. Mazina

Chemistry & Biochemistry Theses & Dissertations

Using chlorine as a drinking water disinfectant may have potential health effects due to its reactivity with organic amino nitrogen compounds found in the stomach. Organic N-chloramines have been shown to form in the stomachs of laboratory rats. The possible reactions of N-chloramines in the stomach fluid were examined in this study using a model radiolabeled N-chloramine. ³⁶Cl-N-Chloropiperidine, was synthesized and purified to remove ³⁶Cl-chloride. Stomach fluid was obtained from Sprague-Dawley rats which had been first fasted for 24 or 48 hours and then administered 3 mL of deionized water. Different concentrations of radiolabeled chloramine were reacted with …

Plasma And Tumor Levels Of Somatostatin (Srif) And Somatostatin Immunochemistry In Medullary Thyroid Carcinoma: Apparently Discrepant Preliminary Results, B. Franc, J. A. Chayvialle, E. Modigliani, C. Calmettes, B. Caillou, N. Dutrieux-Berger, C. Houdent, M. Kujas

Henry Ford Hospital Medical Journal

Eighteen cases of medullary thyroid carcinoma (MTC) (11 hereditary) had parallel measurements of basal plasma levels of somatostatin (SRIF), levels of SRIF extracted from fresh tumor tissue (radioimmunoassay), and immunohistochemistry (peroxidase-antiperoxidase method) using an anti-SRIF antibody on paraffin sections. Immunohistochemistry disclosed some cell positivity in nine cases (50%). Plasma levels of SRIF were above normal (> 50 pg/mL expressed in terms of the 14 amino acid SRIF peptide) in only two of 12 patients. Extraction of fresh tumor tissue detected SRIF in 60% of our cases: two patients > l.200pg/mg (equivalents 14). with the other positive values ranging between 13 and …

Impact Of Prospective Screening For Multiple Endocrine Neoplasia Type 2, Robert F. Gagel, Armen H. Tashjian Jr., Tim Cummings, Nick Papathanasopoulos, Seymour Reichlin

Henry Ford Hospital Medical Journal

Prospective annual screening for hereditary medullary thyroid carcinoma (MTC) in the J-kindred, currently a 117-member family with multiple endocrine neoplasia type 2A, began in 1969. During the initial screening, 12 patients were found to have MTC. Subsequent screening has detected C-cell abnormalities (C-cell hyperplasia or microscopic MTC) in 22 of 23 addilional family members thyroidectomized for abnormal calcium- or pentagastrin-provocative calcitonin (CT) test results. Seven of the initial 12 patients thyroidectomized in 1970 to 1971 and 19 of 23 individuals thyroidectomized since 1971 remain disease-free by all criteria; three patients thyroidectomized since 1971 have had clearly abnormal serum CT measurements …

Subtotal Adrenalectomy In Multiple Endocrine Neoplasia Type 2, Bertil Hamberger, Margareta Telenius-Berg, Bjorn Cedermark, Staffan Grondal, Bengt-Goran Hansson, Sigbritt Werner

Henry Ford Hospital Medical Journal

We report two patients in whom pheochromocytoma was treated by subtotal adrenalectomy leaving a rim of vascularized cortical tissue in situ. Both patients are doing well without cortisol supplementation although they have subnormal cortisol responses to ACTH stimulation.

Application Of Minisatellite Dna Probes To Linkage In Men-2, Bruce A. J. Ponder, Alec J. Jeffreys, Nicola E. Hartley, Clare Carter, Douglas F. Easton, Hakan Telenius, Margareta Telenius-Berg

Henry Ford Hospital Medical Journal

We describe the potential benefits and the limitations of the use of highly polymorphic minisatellite DNA probes for genetic linkage analysis of multiple endocrine neoplasia type 2A (MEN-2 A). The advantage of these probes is that up to 34 loci can be examined in a single experiment, and since the loci are highly polymorphic, almost every individual in every family is informative. The disadvantage is that the DNA fragment lengths of the alleles at any given locus differ from one family to another, so that families cannot be combined, and large single sibships are needed to obtain significant linkage data. …

One Large Kindred Excludes A Locus For Multiple Endocrine Neoplasia Type 2a From About 25% Of The Human Autosomal Genetic Map, Andrew J. Pakstis, Judith R. Kidd, Carmela M. Castiglione, Beth A. Pletcher, Patricia D. Murphy, Lindsay A. Farrer, Myron Genel, Kenneth K. Kidd

Henry Ford Hospital Medical Journal

This report presents pairwise linkage results from our search for the locus of the gene (MEN2A) for the multiple endocrine neoplasia type 2A (MEN-2A) syndrome in one large kindred (the N kindred), clearly segregating for an autosomal dominant form. About 25% of the autosomal genome is excluded when these new results are combined with those we have published previously. The genetic markers employed are distributed across at least 19 of the 22 autosomes. Seven genetic markers whose chromosomal locations are not yet established have also been studied.