Digital Commons Network^™

Use Of Spirometry For Medical Clearance And Surveillance In Occupations Requiring Respirator Use, Ushang Prakshbhai Desai

USF Tampa Graduate Theses and Dissertations

Medical certification of workers for respirator use is an important activity of occupational medicine health professionals. Spirometry is a diagnostic tool to evaluate respiratory distress/insufficiency that may affect respirator use. In this study, we analyzed the pulmonary function data of 337 workers from different occupations which required medical evaluation to wear a respirator. The American Thoracic Society and National Fire Protection Association criteria were used to evaluate employees. Of 337 workers who were cleared for respiratory use on the basis of medical questionnaires for respirator compliance, 14 (4.15%) failed to pass respirator compliance on the basis of NFPA criteria and …

Molecular And Phenotypic Studies Validating The Role Of The Ecdysone Receptor In The Human Parasite Brugia Malayi, Amruta Mhashilkar

USF Tampa Graduate Theses and Dissertations

Filariasis and onchocerciasis are debilitating diseases affecting 120 million people globally. The massive socio-economic impact of these diseases energized the international community to declare a goal of eliminating filariasis 2020. This resulted in a dramatic increase in the efforts to eliminate filariasis and onchocerciasis, employing a strategy of mass drug administration (MDA). However, these programs rely upon the small arsenal of drugs. This leaves these programs vulnerable to failure in the face of developing resistance and local intolerance to the current drug regimens. Thus, new drugs against these infections are critically needed. A homologue of the ecdysone receptor (EcR), a …

Monitoring For Adverse Events Post Marketing Approval Of Drugs, Karl E. Peace, Macaulay Okwuokenye

Biostatistics: Faculty Publications

This brief communication provides information to those developing monitoring plans for serious adverse events (SAE’s) following regulatory approval of a new drug. In addition, we (1) illustrate how many patients would need to be treated in order to have high confidence of seeing at least 1 pre-specified SAE, (2) show that absence of proof of a SAE is not proof of absence of that SAE, and (3) identify statistical methodology that could be used for formal statistical monitoring of SAE’s.

Microrna Molecular Profiling From Matched Tumor And Bio-Fluids In Bladder Cancer, David A. Armstrong, Benjamin B. Green, John D. Seigne, Alan R. Schned, Carmen Marsit

Dartmouth Scholarship

MicroRNAs have been identified as potential cancer biomarkers due to their presence and stability in many body fluids including urine and plasma, but the relationship of the pattern of expression of these messengers across various biological media has not been addressed and could provide important information in order to translate these biomarkers for epidemiologic or clinical use. We analyzed microRNA of matched FFPE-tumor tissue, plasma, urine exosomes (n = 16) and WBCs (n = 11) from patients with bladder cancer, using Nanostring miRNA assays and droplet digital PCR for validation. Pearson correlations were used to compare expression between …

The Comparative Impact Of Different Patient-Centered Medical Home Domains On Satisfaction Among Individuals Living With Type Ii Diabetes, Jon Mills, Allyson Hall, Rebecca Tanner, Jeffrey Harman, David L. Wood, Charles Lorbeer

Patient Experience Journal

Chronic illnesses like type 2 diabetes are costly and difficult to treat. Patient-centered medical homes (PCMH) have the potential to improve patient satisfaction in this population. However, which domains have the most impact on patient satisfaction has not been established. The aim of this study was to assess the relative strength of association between seven PCMH domains and two measures of satisfaction. Cross-sectional data were used in this observational study collected from a random sample of adults aged 18-89 with type 2 diabetes (n=1301) seen at 4 PCMHs. The Ambulatory Care Experiences Survey instrument was used to assess all measures. …

Understanding How Young People Experience Risk With Online-To-Offline Sexual Encounters: A Second Qualitative Phase For The Ch@T Project, Elizabeth Vp Marwah

USF Tampa Graduate Theses and Dissertations

This study investigates how heterosexual young people understand and manage risks related to meeting sexual partners online in the United States. The purpose of this study is to help inform the development of culturally-appropriate sexual risk communication and health promotion messages for young people by linking public health knowledge of adolescent sexual health and eHealth with anthropological theories of risk. With qualitative data from two rounds of semi-structured interviews and two group interviews with university students in central Florida, this study shows how young people experience and prioritize more social-emotional risks in meeting online-to-offline sexual partners compared to physical risks. …

Factors Associated With High Risk Infant Follow-Up Attendance, Martha Grant Fuller

Dissertations

Prematurity is a significant public health problem and preterm infants face well described risks of adverse neurodevelopmental outcomes. Bronfenbrenner’s bioecological theory of development describes interactions between biological and environmental factors and explains how these interactions can impact development. Systematic follow-up of preterm, high-risk infants is recommended for early identification of problems and provision of interventions and support services. Most research on follow-up attendance has involved small, single sites. A retrospective analysis of population based data available in the California Children’s Services High Risk Infant Follow-up Quality of Care Initiative (HRIF-QCI) data system was performed to examine factors associated with attendance …

Occupational Exposure To Chemical And Physical Contaminants: Sex-Differentiated Analysis, France Labrèche, Aude Lacourt, Jérôme Lavoué

Rapports de recherche scientifique

La survenue des lésions professionnelles varie selon le sexe. Une des principales explications évoquées est l’existence de nettes différences d’exposition en milieu de travail, découlant notamment des professions occupées par les hommes et par les femmes et de la nature des tâches effectuées. Cependant, il n’existe pas de données solides pour appuyer cette assertion et les analyses traditionnelles en milieu de travail se sont le plus souvent limitées à rapporter le risque en fonction du sexe, sans identifier les raisons pouvant expliquer les différences de risque observées.

Tant le gouvernement du Québec que l’Organisation mondiale de la santé ou les …

Procédures Et Évaluation Du Potentiel Pro-Inflammatoire Des Nanoparticules, Valérie Lavastre, David Gonçalves, Denis Girard

Rapports de recherche scientifique

Plusieurs pays industrialisés, incluant le Canada, ont opté pour le développement des nanotechnologies étant donné le grand potentiel économique que cela représente. Au Québec, de nombreuses entreprises de production de nanoparticules (NP) sont déjà implantées et il y a fort à parier que d’autres suivront ce mouvement d’ici peu. Ce faisant, le nombre de travailleurs œuvrant dans les domaines des nanotechnologies en général ou dans la fabrication et synthèse des NP augmentera grandement dans les prochaines années. Il est donc capital de prévenir le développement de maladies et d'accidents du travail reliés aux NP dont la cause est souvent d'ordre …

Cross-Sectional Associations Between Exposure To Persistent Organic Pollutants And Leukocyte Telomere Length Among U.S. Adults In Nhanes, 2001-2002., Susanna D. Mitro, Linda S. Birnbaum, Belinda L. Needham, Ami R. Zota

Environmental and Occupational Health Faculty Publications

Background: Exposure to persistent organic pollutants (POPs) such as dioxins, furans, and polychlorinated biphenyls (PCBs) may influence leukocyte telomere length (LTL), a biomarker associated with chronic disease. In vitro research suggests dioxins may bind to the aryl hydrocarbon receptor (AhR) and induce telomerase activity, which elongates LTL. However, few epidemiologic studies have investigated associations between POPs and LTL.

Objectives: We examined the association between 18 PCBs, 7 dioxins, and 9 furans and LTL among 1,330 U.S. adults from NHANES 2001-2002. Methods: We created three summed POP metrics based on toxic equivalency factor (TEF), a potency measure including affinity for the …

A Tail Of Two Phages: Genomic And Functional Analysis Of Listeria Monocytogenes Phages Vb_Lmos_188 And Vb_Lmos_293 Reveal The Receptor-Binding Proteins Involved In Host Specificity, Aidan Casey, Kieran Jordan, Horst Neve, Aidan Coffey, Olivia Mcauliffe

Department of Biological Sciences Publications

The physical characteristics of bacteriophages establish them as viable candidates for downstream development of pathogen detection assays and biocontrol measures. To utilize phages for such purposes, a detailed knowledge of their host interaction mechanisms is a prerequisite. There is currently a wealth of knowledge available concerning Gram-negative phage-host interaction, but little by comparison for Gram-positive phages and Listeria phages in particular. In this research, the lytic spectrum of two recently isolated Listeria monocytogenes phages (vB_LmoS_188 and vB_LmoS_293) was determined, and the genomic basis for their observed serotype 4b/4e host-specificity was investigated using comparative genomics. The late tail genes of these …

Using Height-For-Age Differences (Had) Instead Of Height-For-Age Z-Scores (Haz) For The Meaningful Measurement Of Population-Level Catch-Up In Linear Growth In Children Less Than 5 Years Of Age, Jef L. Leroy, Marie Ruel, Jean-Pierre Habicht, Edward A. Frongillo Jr.

Faculty Publications

Background: Evidence from studies conducted in nutritionally deprived children in low- and middle-income countries (LIMC) in past decades showed little or no population-level catch-up in linear growth (mostly defined as reductions in the absolute height deficit) after 2 years of age. Recent studies, however, have reported population-level catch-up growth in children, defined as positive changes in mean height-for-age z-scores (HAZ). The aim of this paper was to assess whether population-level catch-up in linear growth is found when height-for-age difference (HAD: child’s height compared to standard, expressed in centimeters) is used instead of HAZ. Our premise is that HAZ is inappropriate …

Real-Time Detection Of Breast Cancer Cells Using Peptidefunctionalized Microcantilever Arrays, Hashem Etayash, Keren Jiang, Sarfuddin Azmi, Thomas Thundat, Kamaljit Kaur

Pharmacy Faculty Articles and Research

Ligand-directed targeting and capturing of cancer cells is a new approach for detecting circulating tumor cells (CTCs). Ligands such as antibodies have been successfully used for capturing cancer cells and an antibody based system (CellSearch®) is currently used clinically to enumerate CTCs. Here we report the use of a peptide moiety in conjunction with a microcantilever array system to selectively detect CTCs resulting from cancer, specifically breast cancer. A sensing microcantilever, functionalized with a breast cancer specific peptide 18-4 (WxEAAYQrFL), showed significant deflection on cancer cell (MCF7 and MDA-MB-231) binding compared to when exposed to noncancerous (MCF10A and HUVEC) cells. …

The Perception Of Menstruation And Treatment Of Menstrual Ailments Among Tibetan Women In Mcleod Ganj, Himachal Pradesh, Kara Spafford

India: Public Health, Policy Advocacy, and Community

Despite recent incorporation of quality of life assessments into goal setting, menstrual ailments are still left out of public health initiatives in developing countries. Due to lack of studies on perceptions of menstruation and treatment options for menstrual ailments, the specific health needs of Tibetan women are not met. The present study seeks to determine how Tibetan women are influenced by societal views of menstruation and to explore access to treatment for menstrual problems in McLeod Ganj, Himachal Pradesh. A total of thirty-seven semi-structured interviews were conducted among Tibetan doctors at Men-Tsee-Khang (Tibetan Medical and Astronomy Institute) and Tibetan women …

Implementation Of The International Health Regulations (2005) Through Cooperative Bioengagement, Claire J. Standley, Erin M. Sorrell, Sarah Kornblet, Julie E. Fischer, Rebecca Katz

Health Policy and Management Faculty Publications

Cooperative bioengagement efforts, as practiced by U.S. government-funded entities, such as the Defense Threat Reduction Agency’s Cooperative Biological Engagement Program, the State Department’s Biosecurity Engagement Program, and parallel programs in other countries, exist at the nexus between public health and security. These programs have an explicit emphasis on developing projects that address the priorities of the partner country as well as the donor. While the objectives of cooperative bioengagement programs focus on reducing the potential for accidental or intentional misuse and/or release of dangerous biological agents, many partner countries are interested in bioengagement as a means to improve basic public …

Cross-Cultural Childbirth: Prioritizing The Healthcare Experiences Of Migrant Women In Competent Models Of Care, Emma Hall

Independent Study Project (ISP) Collection

In the context of the feminization of increasing global migration, it is impossible to understand maternal and child health in a given country without considering the experience of female migrants. As the total migrant population increases in the European Union, migration and its effects on health care provision in receiving countries and the experiences of immigrant populations must be recognized. Past research exposes an increased risk of complications and maternal mortality in migrant populations, but little information exists on the tangible programs that could respond to disparity. According to the World Health Organization, maternal health refers to the health of …

Prevalence Of Depression Among Active Tb And Tb/Hiv Patients In Kisumu County, Esther Lee

Independent Study Project (ISP) Collection

According to the World Health Organization (WHO), one in four people have been affected by a mental health disorder at one point in their lives.^[1] Kenya’s mental disorders account for 5.9% of the total global burden.[2] Mental disorders like depression is often comorbid with TB and HIV and disproportionately affects those with lower socio-economic income. Kisumu, a city in Nyanza province, has the highest HIV and TB prevalence in Kenya. This study aimed to determine the prevalence of depression among TB non-coinfected and TB/HIV co-infected patients at Jaramogi Oginga Odinga Teaching and Referral Hospital (JOOTRH) and the Clinical …

How Social Determinants Of Health, Health-Seeking Behaviors, And Treatment Adherence Influence And Interact With Endemic Levels Of Pulmonary Tb And Mdr-Tb In Urban Rajasthan, Michelle Kagei

Independent Study Project (ISP) Collection

Tuberculosis, the worlds most deadly infectious disease, remains as one of the major causes of morbidity and mortality in modern-day India. The country has the highest burden of both tuberculosis as well as multidrug-resistant tuberculosis, a more recently emerging menace. This study focuses on the social determinants of health pertaining to tuberculosis, identifying and discussing “at-risk” groups in the population of urban Rajasthan. Jaipur was chosen as the field study location because of the city’s extensive levels of healthcare institutions and facilities. In order to identify common patient demographics as well as issues regarding treatment adherence, medical records and interviews …

Mercury Emissions From Coal-Fired Powerplants, Divya Gade

Environmental Management & Risk Assessment (PH 560)

Mercury is a neurotoxic heavy metal that pose a risk to the public as well as the environmental health. It is a naturally occurring element that is released into the environment from the natural or anthropogenic emissions. Among the anthropogenic emissions, coal-fired powerplants account for approximately 50 percent of the emissions because of the lack of regulations for the emissions from these facilities. The other larger sources of mercury emissions such as municipal waste combustors and medical waste incinerators are subjected to the stringent regulations thereby minimizing their total contribution. Mercury is a natural component of coal and is released …

Relationship Between Emissions Of Human Activities And Ozone Layer Depletion, Umer Murtaza

Environmental Management & Risk Assessment (PH 560)

Ozone depletion always holds an importance being a protective shield to humans and environment as well. Human activities and man-made substances are playing major role to this depletion which is increasing day by day. In this paper influence of man-made substances on ozone depletion and consequences of this depletion have been discussed. Role of chlorofluorocarbons as depleting agents is more comparatively other substances. Due to ozone depletion life on earth is affecting which are resulting different consequences like skin cancer, eye diseases and destruction of crops and aquatic life. EPA has worked a lot to save the ozone and many …

Maternal Health In Villages Of Northern Uttar Pradesh Assessing Options, Practices And Outcomes In Bahraich District, Elizabeth Curtis

India: Public Health, Policy Advocacy, and Community

Maternal mortality distinctly highlights a health burden women face, particularly in developing countries. For that reason, poor maternal outcomes in rural India are a field in which Public Health workers and researchers continue to question and study. This project aims to understand the reasons behind poor maternal health outcomes for village women in Bahraich District of Uttar Pradesh. The focus of this topic is the accessibility of available health services and the attitudes of various players who distribute or consume services of the health system. Through fieldwork with doctors, medical institutions, auxiliary health workers, traditional health workers, and village women, …

Review Of Sampling And Evaluation Techniques For Diesel Exhaust Particulate Matter In The Mining Industry And The Application Of A Vapor Phase Organic Carbon Correction Factor, Ryley Bosch

Graduate Theses & Non-Theses

The health effects associated with diesel exhaust exposure have been documented for decades. However, methods used to assess diesel exhaust have experienced considerable revision over the past twenty years. The latest sampling methodology considers particulate matter elemental carbon (EC) and organic carbon (OC) analysis along with the vapor phase OC analysis. The objective of this study was to evaluate the influence of vapor phase OC on the current National Institute for Occupational Safety and Health (NIOSH) method 5040 sampling and evaluation techniques for diesel exhaust particulate matter.

A pilot study was conducted as part of a larger study evaluation biodiesel …

Misdiagnosis: Dysfunction Between Western Health Organizations And Developing Nations, Dannette Smith Cook

Ex-Patt Magazine

Improving the global public health system is no simple task. Find out how Indonesia can help explain a culture of distrust between developing nations and international health organizations.

The Role Of Place In Explaining Racial Heterogeneity In Cognitive Outcomes Among Older Adults, Sze Yan Liu, M Maria Glymou, Laura B. Zahodne, Christopher Weiss, Jennifer J. Manly

Department of Public Health Scholarship and Creative Works

Racially patterned disadvantage in Southern states, especially during the formative years of primary school, may contribute to enduring disparities in adult cognitive outcomes. Drawing on a lifecourse perspective, we examine whether state of school attendance affects cognitive outcomes in older adults and partially contributes to persistent racial disparities. Using data from older African American and white participants in the national Health and Retirement Study (HRS) and the New York based Washington Heights Inwood Cognitive Aging Project (WHICAP), we estimated age-and gender-adjusted multilevel models with random effects for states predicting years of education and cognitive outcomes (e.g., memory and vocabulary). We …

Work/Family Demands And Cardiometabolic Risk And Sleep Duration In Extended Care Employees: Multilevel Findings From The Work, Family And Health Network, Lisa Berkman, Sze Yan Liu, Leslie Hammer, Phyllis Moen, Laura Cousino Klein, Erin Kelly, Martha Fay, Kelly Davis, Mary Durham, Georgia Karuntzos, Orfeu M. Buxton

Department of Public Health Scholarship and Creative Works

The study investigates the associations of work-family conflict and other work and family conditions with objectively-measured outcomes cardiometabolic risk and sleep duration in a study of employees in nursing homes. Multilevel analyses are used to assess cross-sectional associations between employee and job characteristics and health in analyses of 1,524 employees in 30 extended care facilities in a single company. We examine work and family conditions in relation to two major study health outcomes: 1) a validated, Framingham cardiometabolic risk score based on measured blood pressure, cholesterol, glycosylated hemoglobin (HbA1c), body mass index (BMI), and self-reported tobacco consumption, and 2) wrist …

Virginia Air Quality: Trends, Exposure, And Respiratory Health Impacts, James Blando, My Ngoc Nguyen, Manasi Sheth-Chandra, Muge Akpinar-Elci

Virginia Journal of Science

Air quality is an important determinant of public health and quality of life. A secondary data analysis was carried out to investigate trends and air quality in Virginia. The analysis included an evaluation of two major air pollution source categories, emission of criteria and hazardous air pollutants, ambient concentrations of criteria pollutants, ozone standard violations and associated meteorology, and hospital admissions for asthma and chronic obstructive pulmonary disease in Virginia. Comparisons were also made to national trends and statistics. Data was gathered from many open reputable on-line sources available through various state and federal agencies. Virginia routinely meets 5 of …

Promoting Colorectal Cancer Screening Among Haitian Americans, Steven S. Coughlin, Erica I. Lubetkin, Jennifer L. Hay, Renald Raphael, Selina A. Smith

Journal of the Georgia Public Health Association

Background: Few studies have examined colorectal cancer screening among Haitian Americans, although striking disparities in colorectal cancer screening and mortality are well-documented among U.S. Blacks. Race, socioeconomic status, and place of birth are factors associated with colorectal cancer incidence and mortality patterns.

Methods: In this article, we summarize published studies on colorectal cancer screening among Haitian Americans, identified through bibliographic searches in PubMed and CINAHL through August 2015, and offer recommendations for further research.

Results: Only one qualitative study and three quantitative surveys have examined colorectal cancer screening among Haitian Americans. A qualitative study found important differences in perceptions of …

Sexual Health Education In Georgia: A Role For Reducing Sexually Transmitted Infections Among Adolescents, Madison L. Gates, Veronica Walker, Nancy C. Webb

Journal of the Georgia Public Health Association

Background: In Georgia, sexually transmitted infections (STIs) are a substantial health issue, particularly among young adults in vulnerable and minority populations. The United States Preventive Services Task Force recommends that sexually active adolescents and at-risk adults receive behavioral counseling and education in primary care settings, community organizations, departments of health, and schools.

Methods: The present approach used in Georgia for educating adolescents at high risk for STIs about these diseases was assessed. The data collected included standards for sexual health education, survey results from educators and students, and observations from a pilot study with adolescents detained by the juvenile justice …

#Aulivewholly, Patricia Spangler

Faculty Publications

Andrews University officially launched its new University Health & Wellness initiative on Wednesday, September 23. The initiative will integrate five deeply connected pillars: physical, spiritual, mental, relational and professional wellness, but mainly focus on physical health and wellness to address the gaps that have been identified.

Depression, Obesity, And Metabolic Syndrome: Prevalence And Risks Of Comorbidity In A Population-Based Study Of Mexican Americans, Rene L. Olvera, Douglas E. Williamson, Susan P. Fisher-Hoch, Kristina Vatcheva, Joseph B. Mccormick

School of Mathematical & Statistical Sciences Faculty Publications

Introduction: We examined the prevalence of depression, obesity, and metabolic syndrome and associations between them in a population-based representative cohort of Mexican Americans living on the United States-Mexico border.

Method: The sample in this cross-sectional analysis consisted of 1,768 Mexican American adults (≥ 18 years of age) assessed between the years 2004 and 2010, with whom we tested our central hypothesis of a significant relationship between obesity and depression. Depression was measured using the Center for Epidemiologic Studies-Depression scale (CES-D) with a cutoff score of ≥ 16 for depression and a cutoff score of ≥ 27 for severe depression. We …