Digital Commons Network^™

Network-Driven Plasma Proteomics Expose Molecular Changes In The Alzheimer's Brain, Philipp A. Jaeger, Kurt M. Lucin, Markus Britschgi, Badri Vardarajan, Ruo-Pan Huang, Elizabeth D. Kirby, Rachelle Abbey, Bradley F. Boeve, Adam L. Boxer, Lindsay A. Farrer, Nicole Finch, Neill R. Graff-Radford, Elizabeth Head, Matan Hofree, Ruochun Huang, Hudson Johns, Anna Karydas, David S. Knopman, Andrey Loboda, Eliezer Masliah, Ramya Narasimhan, Ronald C. Petersen, Alexei Podtelezhnikov, Suraj Pradhan, Rosa Rademakers, Chung-Huan Sun, Steven G. Younkin, Bruce L. Miller, Trey Ideker, Tony Wyss-Coray

Pharmacology and Nutritional Sciences Faculty Publications

Background: Biological pathways that significantly contribute to sporadic Alzheimer’s disease are largely unknown and cannot be observed directly. Cognitive symptoms appear only decades after the molecular disease onset, further complicating analyses. As a consequence, molecular research is often restricted to late-stage post-mortem studies of brain tissue. However, the disease process is expected to trigger numerous cellular signaling pathways and modulate the local and systemic environment, and resulting changes in secreted signaling molecules carry information about otherwise inaccessible pathological processes.

Results: To access this information we probed relative levels of close to 600 secreted signaling proteins from patients’ blood samples using …

Aberrant Dna Methylation: Implications In Racial Health Disparity, Xuefeng Wang, Ping Ji, Yuanhao Zhang, Joseph F. Lacomb, Xinyu Tian, Ellen Li, Jennie L. Williams

Department of Biomedical Engineering Faculty Publications

Background Incidence and mortality rates of colorectal carcinoma (CRC) are higher in African Americans (AAs) than in Caucasian Americans (CAs). Deficient micronutrient intake due to dietary restrictions in racial/ethnic populations can alter genetic and molecular profiles leading to dysregulated methylation patterns and the inheritance of somatic to germline mutations. Materials and Methods Total DNA and RNA samples of paired tumor and adjacent normal colon tissues were prepared from AA and CA CRC specimens. Reduced Representation Bisulfite Sequencing (RRBS) and RNA sequencing were employed to evaluate total genome methylation of 5’-regulatory regions and dysregulation of gene expression, respectively. Robust analysis was …

Redefining Medicine: The Epistemology, Political Theory, And Phenomenology Of Health And Disease, Jacqline J. Murillo

Creative Activity and Research Day - CARD

This thesis argues that health needs to be redefined in a more comprehensive fashion, namely as a physiological/biological state, with social, environmental, and individual determinants always related to one’s personal needs to achieve one’s life plan. The benefits of this new definition include more emphasis on the distribution of health as a social good.

Additionally, redefining health puts the value of the individual’s life rather than the strict monetary value of their needed treatment as a focal point. It also draws more attention to medicine as a practice of care, rather than viewing it simply as a technology or science, …

Affecting Tdap Vaccination Rates Among Women: A Multifaceted Intervention, Soneka Wynter

Evidence-Based Practice Project Reports

Despite the availability of a preventive vaccine, the incidence of pertussis in the United States has continued to increase over the past two decades and it is now considered the most common preventable infectious illness. Highly contagious in nature, it is estimated that about 50 million people are infected each year, and approximately 300,000 deaths occur worldwide (Centers for Disease Control and Prevention [CDC], 2012). In 2013, Indiana reported 616 cases (Indiana State Department of Health [ISDH], 2014). In spite of CDC recommendations on strategies that can improve vaccine delivery, rates of immunization remain low nationwide (CDC, 2014). The purpose …

Measuring Progress To Comprehensive Public Health Systems, National Preparedness, And A Culture Of Health, Glen P. Mays

Health Management and Policy Presentations

This update describes recent progress on two national health measurement initiatives: The National Health Security Preparedness Index and the National Longitudinal Survey of Public Health Systems. These longitudinal data sources offer valuable perspectives on how health security practices and public health delivery systems are changing across the U.S.

Geographic Distribution Of Maternal Group B Streptococcus Colonization And Infant Death During Birth Hospitalization: Eastern Wisconsin, Jessica J. F. Kram, Dennis J. Baumgardner, Kiley B. Vander Wyst, Melissa A. Lemke

Journal of Patient-Centered Research and Reviews

Purpose

Maternal group B Streptococcus (GBS) can be transmitted from a colonized mother to newborn during vaginal delivery and may or may not contribute to infant death. This study aimed to explore the geographic distribution and risk factors of maternal GBS colonization and infant death during birth hospitalization.

Methods

We retrospectively studied mothers with live birth(s) in a large eastern Wisconsin hospital system from 2007 through 2013. Associations between maternal and neonatal variables, GBS colonization and infant death were examined using chi-squared, Mann-Whitney U and t-tests. Multivariable logistic regression models also were developed.

Results

Study population (N = 99,305) had …

Associations Of Birth Order With Early Adolescent Growth, Pubertal Onset, Blood Pressure And Size: Evidence From Hong Kong’S “Children Of 1997” Birth Cohort, Man Ki Kwok, Gabriel M. Leung, C. Mary Schooling

Publications and Research

Background: Birth order has been proposed as a cardiovascular risk factor, because the lower birth weight and greater infant weight gain typical of firstborns could programme metabolism detrimentally.

Methods: We examined the associations of birth order (firstborn or laterborn) with birth weight-for-gestational age, length/height and body mass index (BMI) z-scores during infancy, childhood, and puberty using generalized estimating equations, with age at pubertal onset using interval- censored regression and with age-, sex- and height-standardized blood pressure, height and BMI z-scores at 13 years using linear regression in a population-representative Chinese birth cohort: “Children of 1997” (n = 8,327).

Results: Compared …

Continuum Of A Declining Trend In Correct Self-Perception Of Body Weight Among American Adults, Amber Morgan

GS4 Student Scholars Symposium

Background: Over the past few decades, the prevalence of obesity in the United States has steadily increased with the proportion of obese Americans projected to be about fifty percent in 2030. With more than half of adults being overweight or obese (OW/OB), an increasing number of adults failed to accurately perceive body weight, which may be a major barrier to weight loss strategies, thus, presenting a substantial challenge to prevention efforts. The objective of this study was to assess the dynamic trend of body weight related self-perception among American adults and provide recommendations for improving obesity prevention strategies.

Methods …

Inhalable Exposure Levels Of Airborne Mold Spores In Rural Georgia Homes, Jacquelyn Lewis, Alli Mcinerney, Errol Spence, Bushra Shah, Atin Adhikari

GS4 Student Scholars Symposium

Exposure to mold is known to cause allergic symptoms. Most molds produce highly allergenic proteins or glycoproteins that can cause hypersensitivity diseases in susceptible hosts. Between 10% and 60% of genetically susceptible persons develop immediate hypersensitivity to mold. The Institute of Medicine report on Damp Indoor Spaces and Health states that there is sufficient evidence to conclude that a causal relationship exists between the presence of mold and upper respiratory tract symptoms, cough, hypersensitivity pneumonitis in susceptible persons, wheeze, and asthma symptoms in sensitized asthmatic persons. To our knowledge, no research has been conducted in rural Georgia to test the …

Effects Of Serum Levels Of Vitamin A And Precursors On Colorectal Cancer Mortlaity, Chimuanya Okoli

GS4 Student Scholars Symposium

Objective: To examine the relationship between serum levels of Vitamin A and precursors on Colorectal cancer mortality. Methods: A retrospective cohort study was conducted with 14,358 adults who participated in NHANES III. Data was collected via in home interviews and visits by participants to a mobile examination centre for blood sample collection. Characteristics such as family income, educational attainment, marital status, race and ethnicity, alcohol consumption, cigarette smoking, self reported health, type of resident, body size, cancer status at base line, vegetable consumption and fruit juice consumption were examined. Hazard ratio estimates for all-cause and cancer-related deaths among individuals with …

Effect Of Natural Products On Overall Microbial Activity In Household Items, Teyaijah Givens, Nosa Lloyd Nwaonumah, Brittany Loadholt, Bushra Shah, Atin Adhikari

GS4 Student Scholars Symposium

Indoor contamination from microorganisms is an important health hazard issue (e.g., respiratory allergy, infections, and food contamination). Particularly, growth of molds and bacteria in damp environmental conditions could be hazardous for the occupants susceptible to microbial allergens. The growing awareness concerning the adverse effects of chlorine bleach and cleaning chemicals calls for field-testing new natural ingredients with functional properties against microorganisms. Essential oils possess a wide spectrum of antimicrobial activity, which may be of great importance for controlling indoor microbial exposure. The objective of this study was to investigate how microbial growth in different surfaces of homes reacted to the …

Microbial Activity And Airborne Culturable Microbial Concentrations In South Georgia Homes, Alli Mcinerney, Jacquelyn Lewis, Errol Spence, Bushra Shah, Atin Adhikari

GS4 Student Scholars Symposium

Indoor microorganisms and microbial allergens can lead to harmful respiratory effects in the human body such as allergies, asthma, chronic bronchitis, infections, and even contamination of food stuffs. This study was conducted in order to test the indoor microbial pollutants in local Statesboro homes, and relate the findings to respiratory disease symptoms of occupants. Thus far, samples have been collected and data analyzed for 15 homes. This specific part of the study focuses on the amount of adenosine triphosphate (ATP) in homes. ATP is a source of energy produced through glucose metabolism and the citric acid cycle. ATP levels can …

Effect Of Natural Products Against Growth Of Three Allergenic And Toxigenic Molds, Brittany Loadholt, Teyaijah Givens, Nosa Lloyd Nwaonumah, Bushra Shah, Atin Adhikari

GS4 Student Scholars Symposium

Dampness and fungal exposures in buildings are widespread, with estimates ranging from 18% to 50% of buildings being affected. Of the 21.8 million people reported to have asthma in the USA, approximately 4.6 million cases are attributable to dampness and mold exposure in the home. Consequent national annual cost of asthma is about $3.5 billion. Several fungal genera from damp environments were reported to be associated with allergy and/or asthma and some species can release mycotoxins in the environment. Although there are several mold inhibitor or disinfectant solutions and sprays available in the market for cleaning and inhibiting mold growth, …

Secondary Data Analysis Based On Children Health Survey: On Factors Associated To Overall Dental Health Of Children In Usa, Kavita Gohil

GS4 Student Scholars Symposium

The mouth is the portal of entry into the body, thus it is essential to attain and maintain oral health care. This process begins from the early period of life. Humans have two sets of teeth, and they start developing even before birth and development lasts till the age of around 25 years. Thus it is essential to take care of teeth during early stages of life, as they can affect overall well-being of the human. This paper describes how children's oral health is affected by external and internal factors and also risk factors which are associated with their oral …

Airborne Bacterial Exposure At Workers' Breathing Height In An Organic Farm Of Rural Georgia, Tedd Gandy, Nabanita Mukherjee, Bushra Shah, Subhrajit K. Saha, Pratik Banerjee, Atin Adhikari

GS4 Student Scholars Symposium

Organic farming has potentials to contribute substantially to future sustainable agricultural production by improving soil quality, pest control, and reduction of adverse environmental impacts in rural agricultural communities. On the other hand, application of natural farmyard manure may increase the microbial biomass in this environment and consequently microbial exposure levels among workers could be increased. To explore this possibility of excess exposure, particularly to airborne bacteria, we conducted air sampling at the vicinity of poultry and dairy sections of a large organic farm in a rural Georgia location. For air sampling, a Biostage viable cascade impactor was utilized, which comprises …

Ebola And Social Media, Kathryn C. Finch

GS4 Student Scholars Symposium

We were interested in knowing the impact of social media during the 2014-2015 West Africa Ebola epidemic. The aim of this systematic review is to provide clinicians, public health practitioners and policy-makers with a comprehensive overview of the up-to-date literature on Ebola and social media. We critically appraised the quality and utility of these studies, and identified the gaps in our current understanding that invite further research efforts. In particular, we focused on the research questions and the methods of the studies: a) What were the research questions of a given study? b) What study design and research methods were …

Aging Converts Innate B1a Cells Into Potent Cd8+ T Cell Inducers, Catalina Lee-Chang, Monica Bodogai, Kanako Moritoh, Xin Chen, Robert Wersto, Ranjan Sen, Howard A. Young, Michael Croft, Luigi Ferrucci, Arya Biragyn

United States Public Health Resources

B cell dysregulation in aging is thought to mostly occur in conventional B2 cells without affecting innate B1 cells. Elderly humans and mice also accumulate 4-1BBL+ MHC class-IHi CD86Hi B cells of unknown origin. In this article, we report that these cells, termed 4BL cells, are activated murine and possibly human B1a cells. The activation is mediated by aging human monocytes and murine peritoneal macrophages. They induce expression and activation of 4-1BBL and IFN-gR1 on B1a cells to subsequently upregulate membrane TNF-α and CD86. As a result, activated B1a/4BL cells induce expression of granzyme B in CD8+ T cells by …

Détection Des Microorganismes Par Fluorescence/Raman Uv Dans Des Aérosols, Des Suspensions Ou Sur Des Surfaces : Étude Exploratoire, Michaela Skulinova, Geneviève Marchand, Jean-François Gravel, Jacques Lavoie, Yves Cloutier

Rapports de recherche scientifique

Les microorganismes et leurs sous-produits sont présents dans tous les milieux de travail. Ils se retrouvent en suspension dans l’air, dans un liquide ou déposés sur des surfaces. Ils peuvent avoir des impacts importants sur les entreprises et la santé des travailleurs. Leur détection, à l’aide d’approches classiques faisant appel au dénombrement sur milieux gélosés, exige du temps et des ressources considérables. Cette étude vise à explorer une approche alternative et novatrice soit l’utilisation des signaux de fluorescence émis à différentes longueurs d’onde pour la détection et la différenciation de microorganismes en milieu de travail.

Un système mobile de …

A Comparative Analysis Of Attitudes Towards Women Physicians In Nineteenth Century Articles And Novels, Hannah White

Honors Theses

No abstract provided.

The Presence Of Stem Cells In Human Breast Milk And Research Implications, Melody (Brooke) Peterson

Senior Honors Theses

Stem cell therapy research is an expanding area of study as stem cell therapy is believed to have the potential to provide treatment options for numerous disease processes. Currently, embryonic stem cell research is the method of choice to evaluate the potential for stem cell therapy. The use of human embryos for stem cell research raises moral and ethical controversies. Stem cells are found in a variety of mediums, but until the recent discovery of stem cells in human breast milk, the most versatile stem cells have been those found in the human embryo. Human breast milk stem cells could …

Learning From Variation And Change: The 2016 Release Of The National Health Security Preparedness Index, Glen P. Mays

Health Management and Policy Presentations

The 2016 release of the National Health Security Preparedness Index uses an improved computational methodology and validated set of measures to more accurately track national and state progress in protecting the public from the health effects of disasters, outbreaks and other large-scale emergencies. This presentation provides a preview of the new methodology and results.

Sex, Milk, And Cookies: Tackling Sexual Health Promotion On A Catholic College Campus, Mary Franz

All College Thesis Program, 2016-2019

A great divide exists among parents, policy makers, educational institutions, and the public at large regarding how to prevent the negative consequences of sexual activity among young adults. Some educators believe that sex education programs should promote abstinence as the best behavioral goal for students; however, a more intense debate surrounds whether this should be the only message that adolescents receive about sex or just one element of a more comprehensive view of sexuality and informed sex choices. Catholic colleges face a particularly difficult challenge in deciding what information to provide to students and more significantly, which topics to avoid …

Tools And Methods For Zika Prevention In Cachoeira, Bahia, Florence Tesha

Independent Study Project (ISP) Collection

Zika virus, which is mainly transmitted by Aedes aegypti and Aedes albopictus mosquitoes, has become a major health threat in Brazil and other Latin American countries. Brazil is the country that is being most impacted with zika virus in addition to the existing mosquito-borne diseases of dengue and chikungunya. With the increase in zika virus infections, there have also been increasing numbers of infant brain abnormalities such as microcephaly associated to zika. International and local health institutions are working together to control and prevent zika transmission. This project aimed to investigate the various tools and methods employed by the Center …

The Dawn Of De-Extinction. Are You Ready? Ted Talk Annotated Resource List, Benjamin Paul Watson

Undergraduate Research Award

No abstract provided.

Better Together

DePaul Magazine

Faculty have taken full advantage of the university's innovative intercollegiate grant program, and the resulting research is as interesting and diverse as the collaborators themselves. What is resulting is research on "Patient and Primary Care Provider Perspectives on Recreational and Therapeutic Cannabis Use Within a Changing Socioculltural and Political Context;" a new minor in climate change science and policy; a new class, Communication, Coding and Entrepreneurship; brain inflammation research; and the project "Cosmology Meets Continental Philosophy: Natural Laws and Why There Is Something Rather Than Nothing"

A Comparative Study Of Women’S Health Care: Non-Syrian Refugee Women Living In Amman And Syrian Refugee Women Living In Refugee Camps, Megan Kerstein

Independent Study Project (ISP) Collection

The purpose of this study is to compare access and quality of women’s health care in Amman for non-Syrian refugee women and women’s health care in Syrian refugee camps. I also sought to understand how women’s health care could be improved in both Amman and in Syrian refugee camps. I hypothesized that Syrian refugee women in camps will have less access and lower quality women’s health care since refugee camps’ funding is limited, making medical equipment and women’s health care providers short. Since women in Amman often have more stable family situations and jobs, I thought they would have more …

The Efficacy Of The Influenza Vaccine And The Implications On Vaccination Policy, Alexandra Dipietro

Honors Senior Capstone Projects

The purpose of this paper is to examine the efficacy of the influenza vaccine and its implication on vaccination policy as maintaining or increasing vaccination efficacy is important to public health intervention against this virus. To achieve this purpose a literature review will be conducted based on peer-reviewed research to examine current vaccination policy, efficacy of the influenza vaccine, approaches to improve efficacy, and the gap between vaccination policy and scientific evidence.

Suicidal Ideation In Patients Hospitalized For Emergency Medical Treatment Related To Physical Trauma: Effects Of Posttraumatic Stress And Depression, Erin E. Carney

Masters Theses & Specialist Projects

Survivors of physical trauma may be at increased risk for developing suicidal ideation and behavior both during and after their inpatient hospitalization for medical treatment of wounds. It remains to be understood why a population hospitalized for nonpsychiatric reasons may ultimately develop a desire to take their own life. The current study sought to answer this question by hypothesizing that symptoms of posttraumatic stress (PTS) and depression during the recovery period individually mediated the relationship between physical pain and suicidal ideation. Researchers assessed these relationships in 246 patients who were receiving emergency medical treatment for wounds associated with a physically …

Evaluation Of Particulate Metal And Noise Exposures At A Foundry And Recommended Control Strategies, Jeshua Sargetis

Graduate Theses & Non-Theses

An evaluation of current industrial hygiene practices were performed at a foundry located in the Northwestern United States. The foundry was evaluated for respirable and inhalable manganese, respirable crystalline silica and noise exposure. Personal breathing zone sampling was performed using proper safety and health practices on workers in the foundry and around the entire facility. Results showed that workers were being exposed to respirable manganese but not inhalable manganese. Bulk crystalline silica sampling was performed and personal breathing zone sampling was performed as a follow up to certain control measures which showed low concentrations. Area noise sampling was conducted in …

An Exploratory Study Of Carbon Monoxide Exposures In Ice Rink Volunteers, Jonathan Triner

Graduate Theses & Non-Theses

Hockey has grown in popularity in the United States substantially in the last fifty years. The combustion engine has primarily been utilized to power the ice resurfacing equipment to make the ice smooth and able to support the next activity. The exhaust from the combustion engine creates a source of CO that could be harmful to the bystanders if the exhaust is not ventilated from the area properly. Many studies have investigated CO concentrations in ice rinks, but few have evaluated carboxyhemoglobin (COHb) levels as a biological indicator of CO exposure, in order to evaluate the potential health effects of …