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Prescribed Fire And Deer Ticks: A Management Method For The Primary Vector Of Lyme Disease In The Eastern United States, Shane M. Tripp

Graduate Dissertations and Theses

The United States is currently amid a public health crisis caused by the bacteria, Borrelia burgdorferi, that is responsible for Lyme disease. A deer tick, Ixodes scapularis, is the primary vector for these bacteria in the Eastern United States and its explosive population increase and range expansion in the past several decades is responsible for the rapid spread of the disease. Understanding the cause of this growth is dependent on the habitat characteristics that determine the deer tick’s abilities to survive, reproduce, and disperse into new areas and the changes that may have released it from historic limits. Fire suppression …

The Vascular System: A Roundtable, Marian Hamilton, Bridger Antonsen

Collin College Undergraduate Interdisciplinary Student Research Conference

Paper presented:

"Peripheral Vascular System" by Marian Hamilton and Bridger Antonsen

Positive Affect Predicts Cerebral Glucose Metabolism In Late Middle-Aged Adults., Christopher Nicholas, Siobhan M Hoscheidt, Lindsay R Clark, Annie M Racine, Sara E Berman, Rebecca L Koscik, N Maritza Dowling, Sanjay Asthana, Bradley T Christian, Mark A Sager, Sterling C Johnson

GW Biostatistics Center

Positive affect is associated with a number of health benefits; however, few studies have examined the relationship between positive affect and cerebral glucose metabolism, a key energy source for neuronal function and a possible index of brain health. We sought to determine if positive affect was associated with cerebral glucose metabolism in late middle-aged adults (n = 133). Participants completed the positive affect subscale of the Center for Epidemiological Studies Depression Scale at two time points over a two-year period and underwent 18F-fluorodeoxyglucose-positron emission tomography scanning. After controlling for age, sex, perceived health status, depressive symptoms, anti-depressant use, family …

Conflict In South Asia And Its Impact On Health, Siddarth David, Rukhsana Gazi, Mohammed Shafiq Mirzazada, Chesmal Siriwardhana, Sajid Bashir Soofi, Nobhojit Roy

Department of Paediatrics and Child Health

South Asia has a large population affected by different types of protracted conflict and can provide critical insights to understand health challenges in conflict zones.
Health systems in conflict affected areas should prioritise domestic and gender-based violence, along with reproductive and sexual health services.
Mental health and psychosocial services for conflict-affected populations in South Asia need to be strengthened, and these services should be integrated into existing primary care platforms.
Building the capacity of the existing healthcare system and developing a trained local workforce can improve the access to and availability and acceptability of health services in conflict-affected communities.
Research …

Effect Of Michigan State-Funded Child And Adolescent Health Center (Cahc) In Directing The Health And Wellness Of West Michigan's Oakridge School District, Amber M. Bytwerk

Masters Theses

School-based health centers are an integrated and proactive resource to promote health and wellness of students, as well as the surrounding community. Literature shows that the number of school-based health centers are steadily increasing across America, with few looking at their integration into the population. Within West Michigan, only two such clinics are operational. Applying data from the Michigan Profile for Healthy Youth (MiPHY) and primary data collected from school staff and administrators, an evaluation was conducted on the interconnectedness and behavioral effects of a community branching from the school-based health center. This project is based on review of: the …

Investing In Change: Illuminating Interactive Systems In Hiv Research, Communication Diffusion, And Financing In Lesotho, Sharon Elizabeth Watson

USF Tampa Graduate Theses and Dissertations

In the field of HIV, more than 30 years into the epidemic, the need to ensure that what researchers learn makes its way into tangible actions in the real world is especially poignant. This dissertation addresses the critical divide between research production and its translation into practice. It advances ways to measure the investments of citizens and stakeholders in qualitative studies and offers new perspectives on the losses inadvertently caused by particular investments in health research and services. Unfortunately, many of the problems in how we practice and disseminate research are rampant throughout the health and development research sector. Therefore, …

Trap-Neuter-Return Programs And The Importance Of Associated Public Awareness, Nicolette Sliwa

Biology: Student Scholarship & Creative Works

The focus of this paper is to describe a typical Trap-Neuter-Return (TNR) program and highlight the major pros and cons surrounding this somewhat controversial method of managing the overwhelming free-roaming cat population. The effects of the species’ overabundance on the environment and human health are also discussed. Citing studies completed on TNR programs around the globe as well as mathematical models, the effectiveness of this method is compared to other, currently used alternatives. Finally, it has been suggested that the general awareness level a neighborhood possesses about the true goals of TNR programs has a potentially significant impact on the …

Daycare, Decision-Making, And The Determinants Of Health: A Mother-Centric Approach To Understanding Childcare And Child Health In Rural Dharamshala, Arielle Rawlings

Independent Study Project (ISP) Collection

Indian children have long suffered from some of the world’s worst rates of malnutrition. However, there is an evident mismatch between the macro proliferation of India’s intergenerational cycle of malnutrition and the micro ways in which it is often approached, as established views that place blame on mothers for the poor health status of their children have systematically removed blame from underlying structural determinants of health such as government policies, social inequalities, and economic conditions. Taking a mother-centric approach, this study examines the links between childcare practices and maternal decisionmaking in the context of Dharamshala, Kangra District, Himachal Pradesh. Interviews …

¿Querías Salir Embarazada?: La Cultura Y La Salud De Las Embarazadas En Puerto Bello / Did You Want To Get Pregnant?: The Culture And Health Of Pregnant Women In Puerto Bello, Jessie Malone Friedman

Independent Study Project (ISP) Collection

Las mujeres embarazadas ya son, según la perspectiva del médico, pacientes en riesgo. Hay diferentes niveles de riesgo: con algunas clasificadas “en bajo riesgo obstétrico, algunas en alto riesgo obstétrico; incluso, bajo riesgo obstétrico evoluciona a alto riesgo obstétrico.” Por eso, ambos a nivel del médico de alguna embarazada y a nivel nacional de la salud pública, las embarazadas son un enfoque especial de la atención médica, en cualquier caso. En Nicaragua, hay muchas mujeres embarazadas y aún más mujeres que podrían salir embarazadas en cualquier momento. En 2005, las mujeres con capacidad fértil representaron el 41.5% de la población …

Beliefs And Practices Related To Community Water Sources: "The Specialness Of Springs", Anita Kay Westhues

Masters Theses & Specialist Projects

The practice of gathering water from community springs in Kentucky constitutes a rich and complex research setting for the study of folklore beliefs and practices. Local knowledge construction, nostalgia as an evaluative process, contested views about purity and impurity, the protection and retention of a “public commons,” and the crisis which ensues when infrastructure maintenance and the delivery of safe drinking water are no longer guaranteed to communities, are all relevant to this vernacular practice. My thesis explores these topics, informed by fieldwork I conducted in nine Kentucky counties, which included formal and informal interviews with individuals who have used …

Urine Electrolyte Excretion In A Hypertensive Population Of East Africans, Aiste Dobrovolskaite

Masters Theses & Specialist Projects

Chronic noncommunicable diseases (NCDs) are the largest contributor to mortality rates worldwide including in low- and middle- income countries (LMICs) which already suffer from high rates of infectious disease. Among the four major NCDs that cause 38 million deaths annually, cardiovascular disease (CVD) causes 17.5 million of these annual deaths. The primary risk factor of CVD is hypertension. Kenya, a developing country in Sub-Saharan Africa, has a high rate of hypertension with low (2.6%) management rates. Prior research from our lab has identified a population of Kenyans with a high prevalence of hypertension that is not statistically correlated with typical …

Persistent Organic Pollutants And Mortality In The United States, Kristiann Fry, Melinda Power

GW Research Days 2016 - 2020

Background/Objectives: Persistent organic pollutants (POPs) are environmentally and biologically persistent chemicals that include polybrominated diphenyl ethers (PBDEs), per- and polyfluoroalkyl Substances (PFASs), polychlorinated biphenyls (PCBs), and organochlorine (OC) pesticides. Currently, there is limited data on the association between exposure to POPs and the risk of mortality in the general US population. The objective of this study was to determine if higher exposure to POPs are associated with greater risk of all-cause, cancer, heart/cerebrovascular disease, or other-cause mortality in persons aged 60 years and older.

Methods: The analyses included participants aged 60 years and older from the 1999-2006 National Health and …

Rapid And Rigorous Il-17a Production By A Distinct Subpopulation Of Effector Memory T Lymphocytes Constitutes A Novel Mechanism Of Toxic Shock Syndrome Immunopathology, Peter A. Szabo, Ankur Goswami, Delfina M. Mazzuca, Kyoungok Kim, David B. O'Gorman, David A. Hess, Ian D. Welch, Howard A. Young, Bhagirath Singh, John K. Mccormick, S. M.Mansour Haeryfar

United States Public Health Resources

Toxic shock syndrome (TSS) is caused by staphylococcal and streptococcal superantigens (SAgs) that provoke a swift hyperinflammatory response typified by a cytokine storm. The precipitous decline in the host's clinical status and the lack of targeted therapies for TSS emphasize the need to identify key players of the storm's initial wave. Using a humanized mouse model of TSS and human cells, we herein demonstrate that SAgs elicit in vitro and in vivo IL-17A responses within hours. SAg-triggered human IL-17A production was characterized by remarkably high mRNA stability for this cytokine. A distinct subpopulation of CD4+ effector memory T (TEM) cells …

A Review Of Carbon Disulfide-Gc/Fid Versus Thermal Desorption-Gc/Ms Methods Through The Lens Of Analytical Proficiency And Human And Environmental Health Risk, Vanessa Frost Barnes

Graduate Theses & Non-Theses

NIOSH Method 2549 uses a hyphenated thermal desorption-gas chromatography/mass spectrometry instrumental method with thermal desorption tubes as the sample media for assessment of a variety of volatile and semi-volatile compounds. Other methods in the NIOSH Manual of Analytical Methods use solvent extraction methods for analysis. Of note are those methods that require the analysis of coconut charcoal tubes using carbon disulfide extraction and subsequent analysis via gas chromatography-flame ionization detector. Presented here is a comparison of the methodologies with regard to environmental and occupational health ramifications, as well as method sensitivity as evaluated via limits of detection and compound ranges. …

Bioaerosol Exposures From Three Utah Cattle Operations, Clark Evans

Graduate Theses & Non-Theses

Bioaerosol is a generic term used to describe dusts that are produced by and or contain biological material. These dusts can potentially contain the following hazardous agents; bacteria, viruses, bacterial endotoxins, and/or mycotoxins from mold spores. Respiratory inflammation, allergies, cancers, and infectious diseases can occur from exposure to a variety of bioaerosol agents. Controlling bioaerosol exposures is very complicated due to the limited amount of research available and because there are no established regulatory or authoritative exposure limits.

Three cattle operations, two beef and one Dairy, in Utah were investigated to establish exposure profiles of the full-time employees that directly …

Being Transgender And Seeking Healthcare In The World’S Most Liberal City, Nicole Sharpe

Independent Study Project (ISP) Collection

The right to the highest form of healthcare is one of the most essential rights a person should have. It should be accessible to all human beings, and it appears this is not the case when it comes from the transgender population in the Netherlands and the U.S. In addition to transitional health care needs like hormonal treatment and surgery, transgender people require the same variety of general health care needs as many other groups of individuals. When obstacles create stigma within health care providing facilities, transgender individuals may be less inclined or discouraged to seek the care they need. …

Outcomes After Diagnosis Of Mild Cognitive Impairment In A Large Autopsy Series, Erin L. Abner, Richard J. Kryscio, Frederick A. Schmitt, David W. Fardo, Daniela C. Moga, Eseosa T. Ighodaro, Gregory A. Jicha, Lei Yu, Hiroko H. Dodge, Chengjie Xiong, Randall L. Woltjer, Julie A. Schneider, Nigel J. Cairns, David A. Bennett, Peter T. Nelson

Epidemiology and Environmental Health Faculty Publications

OBJECTIVE: To determine clinical and neuropathological outcomes following a clinical diagnosis of mild cognitive impairment (MCI).

METHODS: Data were drawn from a large autopsy series (N = 1,337) of individuals followed longitudinally from normal or MCI status to death, derived from 4 Alzheimer Disease (AD) Centers in the United States.

RESULTS: Mean follow‐up was 7.9 years. Of the 874 individuals ever diagnosed with MCI, final clinical diagnoses were varied: 39.2% died with an MCI diagnosis, 46.8% with a dementia diagnosis, and 13.9% with a diagnosis of intact cognition. The latter group had pathological features resembling those with a final clinical …

Biokinetics Of Nanomaterials: The Role Of Biopersistence, Peter Laux, Christian Riebeling, Andy M. Booth, Joseph D. Brain, Josephine Brunner, Cristina Cerrillo, Otto Creutzenberg, Irina Estrela-Lopis, Thomas Gebel, Gunnar Johanson, Harald Jungnickel, Heiko Kock, Jutta Tentschert, Ahmed Tlili, Andreas Schäffer, Adriënne J. A. M. Sips, Robert A. Yokel, Andreas Luch

Pharmaceutical Sciences Faculty Publications

Nanotechnology risk management strategies and environmental regulations continue to rely on hazard and exposure assessment protocols developed for bulk materials, including larger size particles, while commercial application of nanomaterials (NMs) increases. In order to support and corroborate risk assessment of NMs for workers, consumers, and the environment it is crucial to establish the impact of biopersistence of NMs at realistic doses. In the future, such data will allow a more refined categorization of NMs. Despite many experiments on NM characterization and numerous in vitro and in vivo studies, several questions remain unanswered including the influence of biopersistence on the toxicity …

Causal Pathways From Enteropathogens To Environmental Enteropathy: Findings From The Mal-Ed Birth Cohort Study, Margaret N. Kosek, Zulfiqar Ahmed Bhutta, Anita K. M. Zaidi, Imran Ahmed, Syed Asad Ali, Muneera Rasheed, Sajid Bashir Soofi, Ali Turab, Didar Alam, Shahida Qureshi

Department of Paediatrics and Child Health

Background: Environmental enteropathy (EE), the adverse impact of frequent and numerous enteric infections on the gut resulting in a state of persistent immune activation and altered permeability, has been proposed as a key determinant of growth failure in children in low- and middle-income populations. A theory-driven systems model to critically evaluate pathways through which enteropathogens, gut permeability, and intestinal and systemic inflammation affect child growth was conducted within the framework of the Etiology, Risk Factors and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development (MAL-ED) birth cohort study that included children from eight countries. …

Ebola Virus - Epidemiology, Diagnosis, And Control: Threat To Humans, Lessons Learnt, And Preparedness Plans - An Update On Its 40 Year's Journey, Raj Kumar Singh, Kuldeep Dhama, Yashpal Singh Malik, Muthannan Andavar Ramakrishnan, Kumaragurubaran Karthik, Rekha Khandia, Ruchi Tiwari, Ashok Munjal, Mani Saminathan, Perumal Arumugam, Sunil Kumar Joshi

Bioelectrics Publications

Ebola virus (EBOV) is an extremely contagious pathogen and causes lethal hemorrhagic fever disease in man and animals. The recently occurred Ebola virus disease (EVD) outbreaks in the West African countries have categorized it as an international health concern. For the virus maintenance and transmission, the non-human primates and reservoir hosts like fruit bats have played a vital role. For curbing the disease timely, we need effective therapeutics/prophylactics, however, in the absence of any approved vaccine, timely diagnosis and monitoring of EBOV remains of utmost importance. The technologically advanced vaccines like a viral-vectored vaccine, DNA vaccine and virus-like particles are …

The Benefits Of Breastfeeding, Annagrace E. Anderson

Senior Honors Theses

Breast milk is the gold standard for infant nutrition. In the past, infant formula was promoted as equal or superior to breast milk. However, research has shown that breastfeeding is the superior form of infant nutrition except in rare circumstances. Breast milk provides for all of a newborn’s caloric needs and has the correct balance of nutrients to promote proper development. In addition, breast milk provides protection against illnesses, supports an infant’s immune system, and promotes life-long health for the newborn. Mothers also experience personal benefits by breastfeeding such as decreased cancer risks, bonding with their babies, and faster postpartum …

Resilience Of Romanian Institutions During The Global Gag Rule: 20012007, Sara Hayet

Independent Study Project (ISP) Collection

There is a wealth of literature about the negative effects of the executive order called the Global Gag Rule, officially known as the Mexico City Policy, and its various manifestations. Despite this, there is a gap in the research about how institutions in affected countries respond to the Global Gag Rule’s family planning restrictions. This qualitative study seeks to provide some insight into how Romanian institutions responded during President George W. Bush’s reinstatement of the policy by using a model of social resilience. Through a literature review of three subjects (social resilience, the Global Gag Rule, and Romania’s family planning …

Sleep Disorders And Kidney Transplant Outcomes: Findings From An 18-Year (1997-2015) Historical Cohort Study, Margaret M. Lubas

Health Services Research Dissertations

A historic cohort study of kidney transplant recipients with a failed graft was conducted to examine the associations between sleep disorders and kidney transplant outcomes. Adult kidney transplant recipients who were transplanted and failed or died with a functioning graft during the designated study time period (January 1, 1997 to September 1, 2015, inclusive) were included (n=299). The primary independent variables, any sleep disorder and any sleep-disordered breathing disorders, were defined through a diagnosis in a subject’s medical record. Transplant outcomes included: death with a functioning graft, graft survival time, and patient survival time after graft failure.

Chi-square statistics were …

Cis-Eqtl-Based Trans-Ethnic Meta-Analysis Reveals Novel Genes Associated With Breast Cancer Risk, Joshua Hoffman, Rebecca Graff, Nima Emami, Caroline Tai, Michael Passarelli

Dartmouth Scholarship

Breast cancer is the most common solid organ malignancy and the most frequent cause of cancer death among women worldwide. Previous research has yielded insights into its genetic etiology, but there remains a gap in the understanding of genetic factors that contribute to risk, and particularly in the biological mechanisms by which genetic variation modulates risk. The National Cancer Institute's "Up for a Challenge" (U4C) competition provided an opportunity to further elucidate the genetic basis of the disease. Our group leveraged the seven datasets made available by the U4C organizers and data from the publicly available UK Biobank cohort to …

Evaluating Value-Based Frameworks Used For Relapsed Or Refractory Multiple Myeloma Regimens: Icer Report, Asco Value Framework, And Nccn Evidence Blocks, Laurence M. Djatche, Pharmd, Joseph Goble, Pharmd, Grace Chun, Pharmd, Stefan Varga, Pharmd

College of Population Health Posters

BACKGROUND: With the continuous rise in costs for oncology drugs, the Institute for Clinical and Economic Review (ICER), the American Society of Clinical Oncology (ASCO) and the National Comprehensive Cancer Network (NCCN) have developed value-based frameworks (VBFs) to assist stakeholders in formulary and treatment decisionmaking. While emerging VBFs have the potential to significantly impact therapeutic options for patients, it is important to understand the differences associated with those VBFs within a therapeutic area. OBJECTIVE: To compare ICER, ASCO, and NCCN VBFs across three therapeutic options for relapsed or refractory multiple myeloma (RRMM).

METHODS: The values of carfilzomib (CFZ), elotuzumab (ELO), …

Th1 Differentiation Drives The Accumulation Of Intravascular, Non-Protective Cd4 T Cells During Tuberculosis, Michelle A. Sallin, Shunsuke Sakai, Keith D. Kauffman, Howard A. Young, Jinfang Zhu, Daniel L. Barber

United States Public Health Resources

Recent data indicate that the differentiation state of Th1 cells determines their protective capacity against tuberculosis. Therefore, we examined the role of Th1-polarizing factors in the generation of protective and non-protective subsets of Mtb-specific Th1 cells. We find that IL-12/23p40 promotes Th1 cell expansion and maturation beyond the CD73+CXCR3+T-betdim stage, and T-bet prevents deviation of Th1 cells into Th17 cells. Nevertheless, IL- 12/23p40 and T-bet are also essential for the production of a prominent subset of intravascular CX3CR1+KLRG1+ Th1 cells that persists poorly and can neither migrate into the lung parenchyma nor control Mtb growth. Furthermore, T-bet suppresses development of …

Inflammatory Potential Of Diet, Weight Gain, And Incidence Of Overweight/Obesity: The Sun Cohort, Alyson Haslam, Sara Wagner Robb, James R. Hébert, Hanwen Huang, Michael David Wirth, Nitin Shivappa, Mark H. Ebell

Faculty Publications

Objective

The Dietary Inflammatory Index (DII)TM, which was developed to characterize the inflammatory potential of a person’s diet, has been shown to be associated with inflammatory conditions such as cancer. The present study aimed to investigate the association between DII scores and colorectal adenoma (CRA), a pre-cancerous condition.

Design

Responses to baseline dietary questionnaires were used calculate DII scores. In a cross-sectional study design, the association between DII scores and CRA prevalence was determined in men and women separately using logistic regression models.

Setting

Ten cancer screening centres across the USA.

Subjects

Participants were those included in the screening arm …

Development Of Tools For Stable Transfection In The Human Filarial Parasite Brugia Malayi Via The Piggybac Transposon System, Johan Chabanon

USF Tampa Graduate Theses and Dissertations

Brugia malayi is one of three species of nematode known to cause lymphatic filariasis (LF) in humans. LF infects over 120 million people, causing debilitating disease. Various global programs have been launched in the past 20 years to eliminate LF. These programs have greatly scaled up the resources and efforts allocated to halting the transmission and reducing disease burden. Only a few drugs are used to treat LF, and resistance is thus a devastating possibility. Research aimed at identifying new drug targets could therefore prove essential in elimination of LF.

Genetic manipulation of B. malayi has been limited to transient …

Occupational Noise Exposure Evaluation Of A Group Of Groundskeepers At A University Campus, Monica Elisa Garcia

USF Tampa Graduate Theses and Dissertations

Every year, twenty-two million workers are exposed to potentially damaging noise at work. Last year, U.S. businesses paid more than $1.5 million in penalties for not protecting workers from noise. (OSHA, 2016). In the United States ten million people have some kind of noise related hearing loss (CDC, 2016) and noise damage to the ear may not be detected until it is great enough to cause hearing impairment.

Grounds keeper’s functions consist of a variety of activities that require the use of powered tools such as mowers, riding mowers, leaf blowers, pressure washers, trimmers/edgers and chainsaws. OSHA has stated that …

Development Of A Transfection System For The Free-Living Amoeba Naegleria Fowleri Using The Piggybac Vector, Kati Räsänen

USF Tampa Graduate Theses and Dissertations

Naegleria fowleri is a free-living amoeba that causes primary amoebic meningoencephalitis (PAM). In the United States, there are between 0-8 cases of PAM per year, with approximately 98% of cases resulting in death. High case fatality and limited treatment options highlight the need for better understanding of this organism in terms of its biology and pathogenicity. Transfection is a useful tool that allows for the study of gene function, but at present no transfection systems have been established for N. fowleri. This study attempts to establish a transfection system for N. fowleri using the piggyBac vector, with the hope of …