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Genomic Epidemiology Of Clostridium Difficile Colonization And Transmission In An Intensive Care Unit Cohort, Brianne Ciferri

Dissertations and Theses

Abstract

Genomic epidemiology of Clostridium difficile colonization and transmission in an intensive care unit cohort

by Brianne Ciferri, MPH

Advisor: C. Mary Schooling, PhD

Introduction: Clostridiodes difficile (C. difficile) is a leading cause of healthcare associated infections (HAI) in the United States and responsible for an estimated incidence of 223,900 cases and 12,800 deaths per year^1,2. C. difficile can cause gastrointestinal illness with symptoms ranging from mild diarrheal illness to a life-threatening condition. C. difficile is an opportunistic pathogen in which spores can live in an undisturbed dormant state within the intestinal tract and become …

Assessing Acceptability Of Covid-19 Vaccine Booster Dose Among Adult Americans: A Cross-Sectional Study, Tesfaye Yadete, Kavita Batra, Dale M. Netski, Sabrina Antonio, Michael J. Patros, Johan C. Bester

School of Medicine Faculty Research

Given the emergence of breakthrough infections, new variants, and concerns of waning immunity from the primary COVID-19 vaccines, booster shots emerged as a viable option to shore-up protection against COVID-19. Following the recent authorization of vaccine boosters among vulnerable Americans, this study aims to assess COVID-19 vaccine booster hesitancy and its associated factors in a nationally representative sample. A web-based 48-item psychometric valid survey was used to measure vaccine literacy, vaccine confidence, trust, and general attitudes towards vaccines. Data were analyzed through Chi-square (with a post hoc contingency table analysis) and independent-sample t-/Welch tests. Among 2138 participants, nearly 62% intended …

Analisa Faktor Psikosial Terhadap Gejala Distress Pada Karyawan Perusahaan Geothermal Pt. X, Khairul Fajarudin, Dadan Erwandi

National Journal of Occupational Health and Safety

This research investigates and compares various psychosocial factors and social environment factors that can influence to one or several distress symptoms to workers in the geothermal company PT. X. This research is semi-quantitative research with a descriptive design. The research found 10 out of 11 dominant indicators of psychosocial factors perceived by half or more of the respondents, with 5 dominant stress symptoms are headache and dizziness, MSDs, angry, sleep difficulties, and change in appetite. The research suggests the company review the workload and current work capacity, improve work process management, improve communication by the foreign workers, and create a …

(R1468) Global Analysis Of An Seirs Model For Covid-19 Capturing Saturated Incidence With Treatment Response, David A. Oluyori, Helen O. Adebayo, Ángel G.C. Pérez

Applications and Applied Mathematics: An International Journal (AAM)

In this work, a new SEIRS model with saturated incidence rate and piecewise linear treatment response is proposed to describe the dynamics of COVID-19. It is assumed that the treatment response is proportional to the number of infected people as long as the incidence cases are within the capacity of the healthcare system, after which the value becomes constant, when the number of confirmed cases exceeds the carrying capacity of the available medical facilities. Thus, the basic reproduction number of the model is obtained. It is proved that the disease-free equilibrium is globally asymptotically stable when the basic reproduction number …

"These Jests Of God": Arrowsmith And Tropical Medicine’S Racial Ecology, James Fitz Gerald

English and Media Studies Faculty Publications

This essay examines Sinclair Lewis's Arrowsmith (1925) through the ethical and ecological contingencies of U.S. tropical medicine in the early twentieth century. With an eye kept on the novel's well-known "St. Hubert " chapters, the essay elaborates the dangerous compromises that even the most well-intentioned medical professionals make in the name of scientific progress. The novel, I argue, summons and yet moves beyond the traditional outbreak narrative to unravel the various political, economic, and cultural strands of U.S. imperial medicine. The novel's platform for applied sanitary science helps me revisit famed public health campaigns, particularly those from Cuba and Panama, …

Understanding Colorectal Cancer: Increasing Screening Rates Amongst Young- And Middle-Aged Adults By Enhancing Prevention Potential, Sarah Agudelo

Nursing | Senior Theses

As nurses, working towards the best health outcomes for our patients is critical to our care. A large aspect of this care includes being knowledgeable of risk factors and precautions to take to avoid conditions and illnesses. Colorectal cancer remains to be a highly preventable disease, yet it is one of the top five leading causes of cancer deaths in the nation. Preventing colorectal cancer requires the efficient use of screening and education, while also addressing barriers of inconvenience and affordability. This senior thesis delves deeper into colorectal cancer prevention by asking the research question: For young and middle-aged adults, …

Adverse Childhood Experiences Among Females In Substance Use Treatment And Their Children: A Pilot Study, Brittany T. Smith, Michael R. Brumage, Keith J. Zullig, Elizabeth A. Claydon, Megan L. Smith, Alfgeir L. Kristjansson

Public and Population Health Faculty Publications and Presentations

Women with substance use disorder (SUD) often have experienced adverse childhood experiences (ACEs). The intergenerational nature of ACEs also put their children at risk for experiencing ACEs. However, no research has explored the prevalence of ACEs in children whose mothers have SUD. This study assessed ACE scores in mothers with SUD and their children and compared them with non-SUD participants. Females with SUD were recruited from a treatment center (n = 50) and compared to females without SUD from the same area (n = 50). The ACE scores of the participants and their children were measured as well as sociodemographic …

Physical Activity May Mitigate Covid-19 Infections In People With Obesity: A Call To Action., Christina D Economos, William H. Dietz, Kathleen Tullie, James F Sallis

Prevention and Community Health Faculty Publications

No abstract provided.

How Community Engagement And The Power Nine Impact Health, Lindsey Shelton, Lindsey V. Shelton

Honors College Theses

The Blue Zones are five different places around the world where people are proven to live healthier and longer lives. In these places, they all share 9 unique habits that are attributed to helping achieve these healthier lives called the Power Nine. In Calloway County, a barrier survey was conducted by five different Murray State departments to see what stopped the residents from achieving their healthiest lives. Community engagement was found to be an important aspect of the Power Nine and was analyzed to see how it can impact one's health.

Institute Of Public Health Newsletter- Volume2, Issue4, Institute Of Public Health (Iph)

Institute of Public Health Newsletter (IPHNL) and Other Publications

No abstract provided.

Thrombosis With Thrombocytopenia Syndrome After Administration Of Azd1222 Or Ad26.Cov2.S Vaccine For Covid-19: A Systematic Review, Usama Waqar, Shaheer Ahmed, Syed M H Ali Gardezi, Muhammad Sarmad Tahir, Zain Ul Abidin, Ali Hussain, Natasha Bahadur Ali, Syed Faisal Mahmood

Medical College Documents

Background: Cases of thrombosis with thrombocytopenia syndrome (TTS) have been reported following vaccination with AZD1222 or Ad26.COV2.S. This review aimed to explore the pathophysiology, epidemiology, diagnosis, management, and prognosis of TTS.
Methods: A systematic review was conducted to identify evidence on TTS till 4th September 2021. Case reports and series reporting patient-level data were included. Descriptive statistics were reported and compared across patients with different sexes, age groups, vaccines, types of thrombosis, and outcomes.
Findings: Sixty-two studies reporting 160 cases were included from 16 countries. Patients were predominantly females with a median age of 42.50 (22) years. AZD1222 was administered …

Examining An Intersection Of Environmental Justice And Covid-19 Risk Assessment: A Review, Ashley Ellis

Honors Theses

This study views the risks associated with the novel coronavirus (COVID-19) as an environmental injustice issue due to the connection between existing environmental disparities and the disproportional negative impacts brought upon by the virus. The social and health determinants attributed to those environmental disparities have traditionally been evaluated as individual risk factors, an approach that fails to gauge the complexity of an environmental injustice issue. This study employs the emerging theory of intersectionality, a belief that phenomena cannot be linked to one principal cause but instead an interconnected web of influences, in order to synthesize the multitude of factors believed …

Exploring The Contextual Factors And Decision-Making Process Of Risky Sexual Behavior Among Homeless Adults In Louisville, Kentucky., Sarah C. Van Heiden

Electronic Theses and Dissertations

Homelessness is a complex public health issue; individuals who experience homelessness are said to engage in risky sexual behaviors at an increased rate and experience a higher prevalence of sexually transmitted infection (STI). While the sexual behaviors of homeless adolescents are commonly studied, little is known about the sexual behaviors of the growing population of older adults, or how they make decisions to engage in sex. Three aims guided this research: 1) to describe the sexual behaviors and sexual decision-making process of homeless older adults, 2) to examine how homeless older adults evaluate the outcomes associated with engaging in risky …

The Association Between Depression And Anxiety With Covid-19 Outcomes., Erica Miller

Electronic Theses and Dissertations

Previous studies have shown that mental disorders affect COVID-19 mortality. This study investigated the effect of depression and/or anxiety on COVID-19 outcomes. Depression/anxiety was defined by actively taking medication and/or diagnosis. The outcomes were ICU admission; ventilation; mortality; and time to mortality. Of 698 hospitalized patients, there were 204 (29%) defined to have either depression or anxiety. There were 109 deaths, and of those, 52 (48%) were diagnosed with depression/anxiety. Multivariable logistic regression and Cox proportional hazards models were used to examine associations. ICU admission and ventilation were not significantly associated with depression/anxiety. Depression/anxiety was associated with mortality (OR: 1.84, …

Effects Of Abstinence-Based Sexual Education Compared To Evidence-Based Sexual Education In K-12 Schools, Lily Probst

The Eleanor Mann School of Nursing Undergraduate Honors Theses

Background: Historically, sexual education in the United States has been abstinence-based (ABSE), meaning that sexual education is centered around encouraging adolescents to abstain from sexual activity outside of wedlock. On the other hand, evidence-based sexual education (EBSE) includes abstinence in its curriculum but does not emphasize it, instead highlighting contraception and prevention strategies. Additionally, EBSE teaches adolescents about healthy relationships, attitudes towards sexuality, gender roles, and provides resources for sexual and reproductive health services. Supplying adolescents in K-12 schools with access to evidence-based sexual education may not only decrease teen pregnancy rates and incidence of sexually transmitted infections (STIs) but …

(R1412) Stability And Bifurcation Of A Cholera Epidemic Model With Saturated Recovery Rate, Huda Abdul-Satar, Raid K. Naji

Applications and Applied Mathematics: An International Journal (AAM)

In this paper, a Cholera epidemic model is proposed and studied analytically as well as numerically. It is assumed that the disease is transmitted by contact with Vibrio cholerae and infected person according to dose-response function. However, the saturated treatment function is used to describe the recovery process. Moreover, the vaccine against the disease is assumed to be utterly ineffective. The existence, uniqueness and boundedness of the solution of the proposed model are discussed. All possible equilibrium points and the basic reproduction number are determined. The local stability and persistence conditions are established. Lyapunov method and the second additive compound …

A Linear Dynamical Perspective On Epidemiology: Interplay Between Early Covid-19 Outbreak And Human Mobility, Shakib Mustavee

Electronic Theses and Dissertations, 2020-2023

This research investigates the impact of human activity and mobility (HAM) in the spreading dynamics of an epidemic. Specifically, it explores the interconnections between HAM and its effect on the early spread of the COVID-19 virus. During the early stages of the pandemic, effective reproduction numbers exhibited a high correlation with human mobility patterns, leading to a hypothesis that the HAM system can be studied as a coupled system with disease spread dynamics. This study applies the generalized Koopman framework with control inputs to determine the nonlinear disease spread dynamics and the input-output characteristics as a locally linear controlled dynamical …

Modeling Recurrence In Idiopathic Subglottic Stenosis With Mobile Peak Expiratory Flow, Kyle Kimura, Liping Du, Lynn D Berry, Li-Ching Huang, Sheau-Chiann Chen, David O Francis, Alexander Gelbard

Faculty, Staff and Student Publications

OBJECTIVES/HYPOTHESIS: We sought to establish normative peak expiratory flow (PEF) data for patients with idiopathic subglottic stenosis (iSGS), evaluate whether immediate changes in PEF after a procedure predict long-term treatment response, and test if a decline in longitudinal PEF is associated with disease recurrence.

STUDY DESIGN: International, prospective, 3-year multicenter cohort study of 810 patients with untreated, newly diagnosed, or previously treated iSGS.

METHODS: iSGS patients consented and enrolled in the North American Airway Collaborative (NoAAC) iSGS

RESULTS: Within the NoAAC iSGS1000 cohort, 810 patients participated in a 3-year, prospective study comparing surgical treatment efficacy and 385 had appropriate PEF …

Understanding Blue Light Retinal Damages And The Methods Of Prevention, Amelia Lee

Senior Honors Theses

Light emitting diode (LED) lights that comprise television screens, phone displays, laptops, and tablets have been studied by scientists in order to understand the implications of blue light radiation and the effects that it has on the human body—especially the retina of the eye. The retina is comprised of highly metabolic cells, and when those cells are placed under oxidative stress, death occurs causing ocular disease. Additionally, excess blue light exposure causes shifts in biological rhythms that govern patterns of alertness and sleep. Recently scientists began studying the methods of blue light prevention. Some studies show that blue light radiation …

Looking Upstream: Promoting Health Equity In Philadelphia Through Novel Partnership Strategies, Adrea Cope, David B. Nash, Sandra E Brooks, David Platt

College of Population Health Faculty Papers

No abstract provided.

Developing And Piloting An E-Learning Module On Respiratory Protection, Emily Girard

Capstone Experience: Master of Public Health

Respiratory diseases are one of the most common causes of occupational illnesses in the United States. Many occupations use personal protective equipment (PPE) in the form of respirators to protect against respiratory hazards when other control methods are not effective. However, some workers may not have had adequate training on their use. An e-learning module was developed to provide information about respirators and their use in agriculture. The interactions of matching, sorting, and review questions require the user to be an active participant with the goal of reinforcing the information. It was hypothesized the average summative assessment score would increase …

Evaluating Nebraska Ems Providers' Ability And Willingness To Respond To Bioterrorism Emergencies, Ryan Houser

Capstone Experience: Master of Public Health

Previous studies have found that public health systems within the United States are inadequately prepared for an act of biological terrorism. This study utilized an Internet-based survey to assess the level of preparedness and willingness to respond to a bioterrorism attack, and identify factors that predict preparedness and willingness among Nebraska Emergency Medical Service providers, who are key to resilience in the face of an attack. The survey was available for one month in 2021 during which 190 EMS providers responded to the survey. The subjects included Registered Nurses, doctors, EMTs, and paramedics. Only 10% of the respondents are both …

Occupational Injuries Associated With Workplace Violence In An Academic Medical Center, Rebecca J. Bonacci

Capstone Experience: Master of Public Health

Violence is a major source of workplace injury in the medical profession. Peer reviewed literature is lacking for workers that have injuries through violence from clients who have intellectual disabilities. Literature for hospital security is also lacking. In this study of workplace violence, we compared injuries among the occupational groups at an academic medical center from 2017-2020. We hypothesized that violence will be similar across the years. Occupational injury and illness data was obtained from an academic medical center. The number of violence cases was divided by the total number of injury cases and reported as a percentage. We found …

Population-Level Prevalence Of Depression And Summary Statistics Of Women With At Least A Year Post-Final Menstruation With And Without Hysterectomy, Happiness Kingi

Capstone Experience: Master of Public Health

Background: Depression is associated with estrogen hormonal changes. There are few comparisons studies on the population-level prevalence of depression in women at least a year post final menstruation with and without hysterectomy.

Objectives: 1) To determine the population-level prevalence of depression in women with at least a year post final menstruation with and without hysterectomy and 2) to calculate the summary statistics of women with at least a year post final menstruation with and without hysterectomy

Methods: A population-based cross-sectional design was used. Respondents were female participants of the U.S. National Health and Nutrition Examination Survey (NHANES) …

Validity, Reliability, And Measurement Invariance Of An Adapted Short Version Of The Hiv Stigma Scale Among Perinatally Hiv Infected Adolescents At The Kenyan Coast, Stanley W. Wanjala, Derrick Ssewanyana, Patrick N. Mwangala, Carophine Nasambu, Esther Chongwo, Stanley Luchters, Charles R. J. C. Newton, Amina Abubakar

Population Health, East Africa

Background: There is a dearth of instruments that have been developed and validated for use with children living with HIV under the age of 17 years in the Kenyan context. We examined the psychometric properties and measurement invariance of a short version of the Berger HIV stigma scale administered to perinatally HIV-infected adolescents in a rural setting on the Kenyan coast.

Methods: A cross-sectional study was conducted among 201 perinatally HIV-infected adolescents aged 12-17 years between November 2017 and October 2018. A short version of the Berger HIV stigma scale (HSS-40) containing twelve items (HSS-12) covering the four dimensions of …

Factors Influencing Us Residents' Willingness To Engage In Domestic Medical Tourism, Hananeh Derakhshan

UNLV Theses, Dissertations, Professional Papers, and Capstones

Domestic medical tourism is a niche market in the medical tourism industry. The purpose of this study was to determine the association of different attributes on U.S residents’ willingness to participate in domestic medical tourism. Based on the medical tourism index (MTI) components, a total of fourteen possible attributes that may impact US residents’ willingness to seek out-of-town care were created and participants were asked to rate the importance of each attribute on their willingness to seek out-of-town care on a 10-point Likert scale. Using principal component analysis, the attributes were grouped into three components: (1) quality-of-care, (2) destination attraction, …

Habitat And Environmental Risks Of Chagas Disease In Low-Income Colonias And Peri-Urban Subdivisions In South Texas, Bára Šafářová, Cecilia H. Giusti, Maria P. Perez, Italo B. Zecca, Ester S. Carbajal, Gabriel L. Hamer, Sarah A. Hamer

School of Medicine Publications

Both the planning and public health literature have discussed proximity to greenspaces as predominantly beneficial to health, based on studies mostly conducted in high-income regions. Understanding the health risks of proximity to greenspace and nature—where pathogens and wildlife coexist—is important, as nature-based solutions are increasingly called for to address complex urban challenges. This exploratory pilot study bridges planning and epidemiology approaches to develop a new method to analyze habitat and environmental factors associated with the risk of vector-borne Chagas disease in a low-income region, South Texas. Chagas disease is endemic in Latin America, where it affects between seven to eight …

Substance Use And Psychological Distress Correlates Of Sleep Quality Among College Students, Juanybeth Morales Ortega

Graduate Theses and Dissertations

Poor sleep quality in college students is a major problem associated with adverse health outcomes, cognitive performance, substance use, and psychological distress. Our study explored how substance use and psychological distress are associated with the sleep quality of college students. We analyzed secondary data collected in 2019 using a cross-sectional survey design. Measures included participants’ demographic characteristics, sleep quality using the Pittsburg Sleep Quality Index (PSQI), drug use, depression using the Patient Health Questionnaire-9 (PHQ-9), and suicidality. After excluding participants with missing information for sleep quality, a total of 555 students remained for the analysis. Our bivariate analysis found that …

Examination Of The Association Between C - Reactive Protein(Crp) And Covid-19 Infection Severity And Length Of Hospitalization, Abdulahi Aremu Ayanwale

Open Access Theses & Dissertations

Chronic stress can lead to many systemic complications and low-grade systemic inflammation including increased levels of inflammatory cytokines, such as C-reactive protein (CRP). CRP is a marker of systemic inflammation and is associated with depression and perceived stress. Elevations can result in ineffective immune responses, thereby increasing the risk of complications and mortality from infections. Recent evidence suggests that uncontrolled inflammatory responses associated with COVID 19 are a major determinant of disease severity.  The COVID 19 is transmitted from one person to another through droplets from coughing, sneezing, talking, touching droplets on surfaces and contamination by hand-to-mouth routes. The mechanism …

The Effectiveness And Safety Of Favipiravir In Covid-19 Hospitalized Patients At Tertiary Referral Hospital, Bali, Indonesia, Herni Damayanti, I Gede K Sajinadiyasa, Hindun Wilda Risni, Rani Sauriasari

Kesmas

COVID-19 is a major public health problem, with still questionable specific cure. Favipiravir is a COVID-19 antiviral that is potentially a therapy for COVID-19. This study aimed to analyze its effectivity and safety in moderate to critical hospitalized patients. This study was a retrospective cohort in a tertiary referral hospital in Denpasar City, Bali Province, Indonesia, from August 2020 to January 2021. There was a total of 192 patients; 96 in the favipiravir group and 96in the non-favipiravir group (remdesivir/oseltamivir). Effectivity was measured by assessing the clinical condition at the end of the isolation period of 14 days. The favipiravir …