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Dna Release From Plant Tissue Using Focused Ultrasound Extraction (Fuse), Alexia Stettinius, Hal Holmes, Qian Zhang, Isabelle Mehochko, Misa Winters, Ruby Hutchison, Adam Maxwell, Jason Holliday, Eli Vlaisavljevich Jan 2023

Dna Release From Plant Tissue Using Focused Ultrasound Extraction (Fuse), Alexia Stettinius, Hal Holmes, Qian Zhang, Isabelle Mehochko, Misa Winters, Ruby Hutchison, Adam Maxwell, Jason Holliday, Eli Vlaisavljevich

Faculty, Staff and Student Publications

PREMISE: Sample preparation in genomics is a critical step that is often overlooked in molecular workflows and impacts the success of downstream genetic applications. This study explores the use of a recently developed focused ultrasound extraction (FUSE) technique to enable the rapid release of DNA from plant tissues for genetic analysis.

METHODS: FUSE generates a dense acoustic cavitation bubble cloud that pulverizes targeted tissue into acellular debris. This technique was applied to leaf samples of American chestnut (

RESULTS: We observed that FUSE can extract high quantities of DNA in 9-15 min, compared to the 30 min required for control …


Poor Sleep Quality And Suicidal Ideation Among Pregnant Women During Covid-19 In Ethiopia: Systematic Review And Meta-Analysis, Aragaw Asfaw Hasen, Abubeker Alebachew Seid, Ahmed Adem Mohammed Jan 2023

Poor Sleep Quality And Suicidal Ideation Among Pregnant Women During Covid-19 In Ethiopia: Systematic Review And Meta-Analysis, Aragaw Asfaw Hasen, Abubeker Alebachew Seid, Ahmed Adem Mohammed

Faculty, Staff and Student Publications

INTRODUCTION: COVID-19 has profoundly impacted the mental health and well-being of pregnant women worldwide. In Ethiopia, the poor sleep quality and suicidal ideation among pregnant women has increased due to the COVID-19 pandemic. This study aimed to provide comprehensive evidence on the prevalence and associated factors of poor sleep quality and suicidal ideation among pregnant women during COVID-19 in Ethiopia.

MATERIALS AND METHODS: This study is based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendation. Data were searched from PubMed, Google Scholar, and African Journals Online from the occurrence of the COVID-19 pandemic to February 2023. …


Feasibility Of Quantitative Diffusion-Weighted Imaging During Intra-Procedural Mri-Guided Brachytherapy Of Locally Advanced Cervical And Vaginal Cancers, Megan C Jacobsen, Bastien Rigaud, Samantha J Simiele, Gaiane M Rauch, Matthew S Ning, Sastry Vedam, Ann H Klopp, R Jason Stafford, Kristy K Brock, Aradhana M Venkatesan Jan 2023

Feasibility Of Quantitative Diffusion-Weighted Imaging During Intra-Procedural Mri-Guided Brachytherapy Of Locally Advanced Cervical And Vaginal Cancers, Megan C Jacobsen, Bastien Rigaud, Samantha J Simiele, Gaiane M Rauch, Matthew S Ning, Sastry Vedam, Ann H Klopp, R Jason Stafford, Kristy K Brock, Aradhana M Venkatesan

Faculty, Staff and Student Publications

Purpose: To determine the feasibility of quantitative apparent diffusion coefficient (ADC) acquisition during magnetic resonance imaging-guided brachytherapy (MRgBT) using reduced field-of-view (rFOV) diffusion-weighted imaging (DWI).

Methods and materials: T2-weighted (T2w) MR and full-FOV single-shot echo planar (ssEPI) DWI were acquired in 7 patients with cervical or vaginal malignancy at baseline and prior to brachytherapy, while rFOV-DWI was acquired during MRgBT following brachytherapy applicator placement. The gross target volume (GTV) was contoured on the T2w images and registered to the ADC map. Voxels at the GTV's maximum Maurer distance comprised a central sub-volume (GTVcenter). Contour ADC mean and standard deviation were …


Sex-Biased Autophagy As A Potential Mechanism Mediating Sex Differences In Ischemic Stroke Outcome, Brian Noh, Louise D Mccullough, Jose F Moruno-Manchon Jan 2023

Sex-Biased Autophagy As A Potential Mechanism Mediating Sex Differences In Ischemic Stroke Outcome, Brian Noh, Louise D Mccullough, Jose F Moruno-Manchon

Faculty, Staff and Student Publications

Stroke is the second leading cause of death and a major cause of disability worldwide, and biological sex is an important determining factor in stroke incidence and pathology. From childhood through adulthood, men have a higher incidence of stroke compared with women. Abundant research has confirmed the beneficial effects of estrogen in experimental ischemic stroke but genetic factors such as the X-chromosome complement can also play an important role in determining sex differences in stroke. Autophagy is a self-degrading cellular process orchestrated by multiple core proteins, which leads to the engulfment of cytoplasmic material and degradation of cargo after autophagy …


Risk Of Depression In A Suburban Primary Care Setting Before And During The Covid-19 Pandemic, Carman H Whiting, Pouran Yousefi, Jude K A Des Bordes, Nahid J Rianon Jan 2023

Risk Of Depression In A Suburban Primary Care Setting Before And During The Covid-19 Pandemic, Carman H Whiting, Pouran Yousefi, Jude K A Des Bordes, Nahid J Rianon

Faculty, Staff and Student Publications

INTRODUCTION: Major depression is a common disorder affecting millions of adults each year. Many population-based surveys showed an increase in the number people with symptoms of depression at the onset of the COVID-19 pandemic. Our aim was to determine and compare the prevalence of depression risk in a primary care setting before and during the COVID-19 pandemic.

METHODS: We conducted a cross-sectional study based on retrospective review of medical records from a large suburban primary care clinic. Records of adults 18 years and older, seen between January 1, 2019 and December 31, 2020 and who had also been screened for …


Timing Of Invasive Mechanical Ventilation And Death In Critically Ill Adults With Covid-19: A Multicenter Cohort Study, Adam Green, Jean-Sebastien Rachoin, Christa Schorr, Phil Dellinger, Jonathan D Casey, Isabel Park, Shruti Gupta, Rebecca M Baron, Shahzad Shaefi, Krystal Hunter, David E Leaf Jan 2023

Timing Of Invasive Mechanical Ventilation And Death In Critically Ill Adults With Covid-19: A Multicenter Cohort Study, Adam Green, Jean-Sebastien Rachoin, Christa Schorr, Phil Dellinger, Jonathan D Casey, Isabel Park, Shruti Gupta, Rebecca M Baron, Shahzad Shaefi, Krystal Hunter, David E Leaf

Faculty, Staff and Student Publications

PURPOSE: To investigate if the timing of initiation of invasive mechanical ventilation (IMV) for critically ill patients with COVID-19 is associated with mortality.

MATERIALS AND METHODS: The data for this study were derived from a multicenter cohort study of critically ill adults with COVID-19 admitted to ICUs at 68 hospitals across the US from March 1 to July 1, 2020. We examined the association between early (ICU days 1-2) versus late (ICU days 3-7) initiation of IMV and time-to-death. Patients were followed until the first of hospital discharge, death, or 90 days. We adjusted for confounding using a multivariable Cox …


Effectiveness Of Telemedicine For Hypertension Patients In Primary Healthcare On Improving Healthcare Access And Blood Pressure In Muang District, Phetchabun Province, Thailand: A Mixed Methods Study, Tassana Thammaros Jan 2023

Effectiveness Of Telemedicine For Hypertension Patients In Primary Healthcare On Improving Healthcare Access And Blood Pressure In Muang District, Phetchabun Province, Thailand: A Mixed Methods Study, Tassana Thammaros

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background: Hypertension services were disrupted by the COVID-19 pandemic, prompting heavy utilization of telemedicine to overcome these challenges. This study aimed to develop and evaluate the effectiveness of telemedicine for hypertension patients in primary healthcare settings, focusing on healthcare access and blood pressure outcomes among hypertension patients in Muang District, Phetchabun Province, Thailand.Methods: This mixed-methods study began with in-depth interviews with healthcare staff until data saturation was reached in April 2023, using analytic induction for analysis. Subsequently, a quasi-experimental study was conducted in primary care facilities in Muang District, Phetchabun Province, Thailand, from May 1st to October 31st, 2023. Hypertensive …


The Effectiveness Of "Teach To Say-No" Intervention On Teacher's Knowledge, Attitude, Feasibility, And Acceptability Towards Child Sexual Abuse Prevention Program In Phnom Penh City, Cambodia: A Mixed Methods Study, Swarnamala Kantipudi Jan 2023

The Effectiveness Of "Teach To Say-No" Intervention On Teacher's Knowledge, Attitude, Feasibility, And Acceptability Towards Child Sexual Abuse Prevention Program In Phnom Penh City, Cambodia: A Mixed Methods Study, Swarnamala Kantipudi

Chulalongkorn University Theses and Dissertations (Chula ETD)

Child sexual abuse is a highly debated issue worldwide. Protecting children from sexual abuse and implementing primary prevention approaches is a crucial task for LMICs. The objective of this research is to evaluate the effectiveness of a CSA prevention program “teach to say-NO". The evaluation includes measuring knowledge and attitudes, as well as analyzing the feasibility and acceptability of the intervention among primary school teachers in a school environment.A total of 146 primary school teachers from 22 public schools in Phnom Penh, Cambodia were involved in the study. Additionally, 29 teachers participated in a qualitative study. The research design consisted …


Formulation Of Polyphenol-Loaded Microemulsions Against Human Breast Cancer Cells, Ghea Putri Cristy Jan 2023

Formulation Of Polyphenol-Loaded Microemulsions Against Human Breast Cancer Cells, Ghea Putri Cristy

Chulalongkorn University Theses and Dissertations (Chula ETD)

Breast cancer is one of the deadliest cancers and is categorized into the hormone-dependent and hormone-independent phenotypes. Plant-derived polyphenols have been deemed as one of possible solutions to combat breast cancer. This study explored inhibition of selected plant polyphenols on human 5-lipoxygenase (5-LOX), and further focused on how microemulsion encapsulation was used to enhance the deliverability of the polyphenols, namely quercetin, kaempferol, and rosmarinic acid, and to understand the nature of these compounds in terms of cytotoxicity and antioxidant properties by performing assays, including DPPH and nitric oxide assays. The results showed that kaempferol has the highest inhibition on 5-LOX …


Knowledge, Attitudes, And Practices (Kap) Towards Indoor Air Pollution Among Residents In Yangon And Mandalay, Myanmar: A Cross-Sectional Study, Min Thant Thaw Jan 2023

Knowledge, Attitudes, And Practices (Kap) Towards Indoor Air Pollution Among Residents In Yangon And Mandalay, Myanmar: A Cross-Sectional Study, Min Thant Thaw

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background: Indoor air pollution (IAP) is a growing public health threat, but little is known about knowledge, attitudes, and practices among urban residents in Myanmar. Rapid development in cities like Yangon and Mandalay might exacerbate pollution while increasing time spent indoors. This study aims to assess the knowledge, attitudes, and practices (KAP) related to Indoor Air Pollution (IAP) among residents of Yangon and Mandalay.Methods: A cross-sectional survey involving 579 participants (100% response rate) was conducted using six-sections questionnaire; socio-economic data, knowledge, attitudes, information accessibility, health perception, and practices. Knowledge and attitudes were evaluated using modified Bloom's cut-off points and Likert …


Health Risk Assessment Of Heavy Metal Contamination In Potato (Solanum Tuberosum) In Jining, Shandong, China, Siyuan Ma Jan 2023

Health Risk Assessment Of Heavy Metal Contamination In Potato (Solanum Tuberosum) In Jining, Shandong, China, Siyuan Ma

Chulalongkorn University Theses and Dissertations (Chula ETD)

Introduction: Heavy metals contamination in soil is a worldwide problem according to contamination also in plants and crops. Heavy metals in crops can cause human health risks such as cancer through oral exposure by crops consumption. Potato is one of underground growing crops that commonly found heavy metals. In China, potato is one of the most popular staple foods, especially in northern regions like Shandong. Therefore, they may have adverse health risk from contaminated potato consumption. Objectives: To find the concentration of heavy metals in potato and assess the non-cancer and cancer risk related to potato consumption among residents in …


Knowledge, Attitude, And Practice (Kap) Towards Atopic Dermatitis (Eczema)Associated With Indoor Environmental Factors In Young Adults Of Yangon, Myanmar, Htoo Tint Tae Jan 2023

Knowledge, Attitude, And Practice (Kap) Towards Atopic Dermatitis (Eczema)Associated With Indoor Environmental Factors In Young Adults Of Yangon, Myanmar, Htoo Tint Tae

Chulalongkorn University Theses and Dissertations (Chula ETD)

Atopic dermatitis,most common type of eczema, a relapsing and pruritic inflammatory skin condition caused by both outdoor and indoor environmental factors. Indoor air quality and indoor environmental factors become hazardous issues for public health consequences, but little is known about knowledge, attitudes, and practices concerning its pollutants are associated with eczema among urban residents in Myanmar within young adults. Therefore, this study aimed to assess the level of (KAP) and identify the association between knowledge, attitude, and practices levels toward atopic dermatitis (eczema) associated with indoor environmental factors in young adults. This cross-sectional study was conducted on 480 participants , …


Knowledge, Attitudes And Practices Of Solid Waste Management In Londhe-Krishnapuri Rural Community Of Jalgaon District, India, Priyanka Chavan Jan 2023

Knowledge, Attitudes And Practices Of Solid Waste Management In Londhe-Krishnapuri Rural Community Of Jalgaon District, India, Priyanka Chavan

Chulalongkorn University Theses and Dissertations (Chula ETD)

Abstract: Improper solid waste management is a critical issue in developing nations but lacks proper infrastructure in rural areas. This study investigates the Knowledge, Attitude, and Practice (KAP) of solid waste management in Londhe-Krishnapuri, a rural community in Jalgaon district, India. Currently, no formal waste management system, so this study explores residents' understanding, views, and methods on waste disposal which will help identify gaps in waste disposal awareness and practices. Information will target interventions, educational programs within the community, insights for policymakers to address disposal challenges. To identify association between knowledge, attitudes, and practices of solid waste management in Londhe-Krishnapuri …


The Role Of Social Media On Utilization Of Hiv Prevention Services Among Men Who Have Sex With Men In Yangon, Myanmar: A Qualitative Study, Thet Zaw Naung Jan 2023

The Role Of Social Media On Utilization Of Hiv Prevention Services Among Men Who Have Sex With Men In Yangon, Myanmar: A Qualitative Study, Thet Zaw Naung

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background: HIV remains a significant global health challenge, disproportionately affecting populations such as men who have sex with men (MSM). In Myanmar, MSM faces high HIV prevalence and numerous barriers to accessing prevention services. Social media has emerged as a powerful tool in health communication, potentially enhancing HIV prevention efforts.Objective: This study explores the role of social media in the utilization of HIV prevention services among MSM in Yangon, Myanmar.Methodology: A qualitative research design was employed, involving in-depth interviews with 40 MSM recruited from two Key Population Service Centers in Yangon. Participants were selected using voluntary sampling, and data were …


The Relationship Between Self-Esteem And Suicidal Risk Among Adolescents In Nakhon Ratchasima, Thailand, Sirakrit Rungrojchaiporn Jan 2023

The Relationship Between Self-Esteem And Suicidal Risk Among Adolescents In Nakhon Ratchasima, Thailand, Sirakrit Rungrojchaiporn

Chulalongkorn University Theses and Dissertations (Chula ETD)

Introduction: Suicide is an important global threat to adolescents worldwide, including Thailand. Adolescence is a crucial phase marked by significant changes in thought patterns, decision-making, behavior, and emotions. These changes can potentially increase risk of suicide. Self-esteem, a crucial factor in mental well-being, also takes shape during this period. Understanding the factors associated with suicide risk and the relationship between self-esteem and suicide risk is essential for developing effective intervention.Objective: The main objective is to find the relationship between self-esteem and suicide risk and to investigate the associated factors of suicide risk among adolescents in Muang District, Nakhon Ratchasima, Thailand.Method: …


Factors Associated With Knowledge, Attitude, And Practice (Kap) Towards The Prevention Of Hypertension Among People Aged 30-64 Years In Tonglu County, China: A Cross-Sectional Study, Yuanyuan Wu Jan 2023

Factors Associated With Knowledge, Attitude, And Practice (Kap) Towards The Prevention Of Hypertension Among People Aged 30-64 Years In Tonglu County, China: A Cross-Sectional Study, Yuanyuan Wu

Chulalongkorn University Theses and Dissertations (Chula ETD)

Introduction: The Global Burden of Disease study shows that poor blood pressure control remains one of the leading risk factors for global burden and death. Most of the general population had a good understanding of hypertension and satisfactory attitudes, but the participant's level of practice was not high. In China, about 270 million people have hypertension, and in Zhejiang, the prevalence of hypertension is higher than the national average. Therefore, knowledge, attitude, and practice toward hypertension play a crucial role in hypertension prevention. Objective: This study aims to assess the level of knowledge, attitude, and practice towards the prevention of …


Prevalence Of Hiv Testing And Its Determinants Among Youths In The Gambia: From 2019/2020 Demographic Health Survey, Abdou Jarju Jan 2023

Prevalence Of Hiv Testing And Its Determinants Among Youths In The Gambia: From 2019/2020 Demographic Health Survey, Abdou Jarju

Chulalongkorn University Theses and Dissertations (Chula ETD)

Introduction: HIV is a pathogen that attacks the immune system. Globally, 3.9 million youth aged 15-24 years living with the virus in 2017. In Sub-Saharan Africa, girls and boys accounted for 63% and 50% respectively. The Gambia, youth accounted for 37% of all HIV cases. Objective: To determine the prevalence and determinant factors of HIV testing among youth15 – 29 years in The Gambia.Methodology: Secondary data were used for analysis. This study population was 7438 youth aged 15 to 29 years. Sociodemographic and Economic knowledge about HIV/AIDS, risky sexual behaviors, and mass media exposure were used as predictors of HIV …


Effectiveness Of Tendingpets Application On Working Memory Among Adolescent In Phrae Province, Thailand : A Quasi-Experimental Study, Phitchasuda Detboon Jan 2023

Effectiveness Of Tendingpets Application On Working Memory Among Adolescent In Phrae Province, Thailand : A Quasi-Experimental Study, Phitchasuda Detboon

Chulalongkorn University Theses and Dissertations (Chula ETD)

Working memory performance refers to the capacity and ability of the brain to temporarily remember and process incoming information while working or solving problems. This competency is crucial for teenagers and is linked to success in learning mathematics, English language, and health-related behaviors. This quasi-experimental research, conducted with a controlled group, aims to explore the effectiveness of the "TendingPETs" application in enhancing working memory capacity and its impact on educational effectiveness and risky behavior among 99 teenagers in Phrae Province, Thailand. The participants were divided into an experimental group of 50 individuals who used the "TendingPETs" application alongside regular classroom …


Radiographic Response To Neoadjuvant Therapy In Pleural Mesothelioma Should Serve As A Guide For Patient Selection For Cytoreductive Operations, Nathaniel Deboever, Nicolas Zhou, Daniel J Mcgrail, Katarzyna Tomczak, Jacqueline L Oliva, Hope A Feldman, Edwin Parra, Jianjun Zhang, Percy P Lee, Mara B Antonoff, Wayne L Hofstetter, Reza J Mehran, Ravi Rajaram, David C Rice, Jack A Roth, Stephen S Swisher, Ara A Vaporciyan, Mehmet Altan, Annikka Weissferdt, Anne S Tsao, Cara L Haymaker, Boris Sepesi Jan 2023

Radiographic Response To Neoadjuvant Therapy In Pleural Mesothelioma Should Serve As A Guide For Patient Selection For Cytoreductive Operations, Nathaniel Deboever, Nicolas Zhou, Daniel J Mcgrail, Katarzyna Tomczak, Jacqueline L Oliva, Hope A Feldman, Edwin Parra, Jianjun Zhang, Percy P Lee, Mara B Antonoff, Wayne L Hofstetter, Reza J Mehran, Ravi Rajaram, David C Rice, Jack A Roth, Stephen S Swisher, Ara A Vaporciyan, Mehmet Altan, Annikka Weissferdt, Anne S Tsao, Cara L Haymaker, Boris Sepesi

Faculty, Staff and Student Publications

BACKGROUND: Malignant pleural mesothelioma (MPM) is associated with poor prognosis despite advances in multimodal therapeutic strategies. While patients with resectable disease may benefit from added survival with oncologic resection, patient selection for mesothelioma operations often relies on both objective and subjective evaluation metrics. We sought to evaluate factors associated with improved overall survival (OS) in patients with mesothelioma who underwent macroscopic complete resection (MCR).

METHODS: Patients with MPM who received neoadjuvant therapy and underwent MCR were identified in a prospectively maintained departmental database. Clinicopathologic, blood-based, and radiographic variables were collected and included in a Cox regression analysis (CRA). Response to …


A Global Perspective Of Advanced Practice Nursing Research: A Review Of Systematic Reviews Protocol, Kelley Kilpatrick, Isabelle Savard, Li-Anne Audet, Abby Kra-Friedman, Reneé Atallah, Mira Jabbour, Wentao Zhou, Kathy Wheeler, Elissa Ladd, Deborah C. Gray, Colette Henderson, Lori A. Spies, Heather Mcgrath, Melanie Rogers Jan 2023

A Global Perspective Of Advanced Practice Nursing Research: A Review Of Systematic Reviews Protocol, Kelley Kilpatrick, Isabelle Savard, Li-Anne Audet, Abby Kra-Friedman, Reneé Atallah, Mira Jabbour, Wentao Zhou, Kathy Wheeler, Elissa Ladd, Deborah C. Gray, Colette Henderson, Lori A. Spies, Heather Mcgrath, Melanie Rogers

Ellmer School of Nursing Faculty Publications

Introduction

In 2020, the World Health Organization called for the expansion and greater recognition of all nursing roles, including advanced practice nurses (APNs), to better meet patient care needs. As defined by the International Council of Nurses (ICN), the two most common APN roles include nurse practitioners (NPs) and clinical nurse specialists (CNSs). They help ensure care to communities as well as patients and families with acute, chronic or complex conditions. Moreover, APNs support providers to deliver high quality care and improve access to services. Currently, there is much variability in the use of advanced practice nursing roles globally. A …


Unsheltered Homeless And Unstably Housed Adults Have Higher Levels Of Stress And More Health Risk Factors Than Sheltered Homeless Adults, Chaelin K Ra, Emily T Hébert, Adam Alexander, Darla E Kendzor, Robert Suchting, Michael S Businelle Jan 2023

Unsheltered Homeless And Unstably Housed Adults Have Higher Levels Of Stress And More Health Risk Factors Than Sheltered Homeless Adults, Chaelin K Ra, Emily T Hébert, Adam Alexander, Darla E Kendzor, Robert Suchting, Michael S Businelle

Faculty, Staff and Student Publications

In the United States, approximately 580,000 individuals were homeless on a single night in 2020. Homelessness can be categorized into three subgroups: sheltered homeless, unsheltered homeless, and unstably housed. Few studies have examined the relations between homelessness subtypes, shelter service utilization, levels of stress experienced, and health risk factors. This study aimed to empirically examine whether shelter status the previous night was related to current stress, recent utilization of shelter-based mental health services, and current health risk factors. Data were collected at multiple homeless shelters in 2016 in the Oklahoma City area (N=575). All participants completed assessments of demographic characteristics, …


Exosomal Lipid Biomarkers Of Oligodendrocyte Pathology To Predict Scoliosis In Children With Cerebral Palsy, Nune Darbinian, Emily C Sparks, Armine Darbinyan, Nana Merabova, Tamara Tatevosian-Geller, Katie Calaku, Sarah Bachman, Huaqing Zhao, Shohreh Amini, Laura Goetzl, Solomon P Samuel, Amer Samdani, Michael E Selzer Jan 2023

Exosomal Lipid Biomarkers Of Oligodendrocyte Pathology To Predict Scoliosis In Children With Cerebral Palsy, Nune Darbinian, Emily C Sparks, Armine Darbinyan, Nana Merabova, Tamara Tatevosian-Geller, Katie Calaku, Sarah Bachman, Huaqing Zhao, Shohreh Amini, Laura Goetzl, Solomon P Samuel, Amer Samdani, Michael E Selzer

Faculty, Staff and Student Publications

INTRODUCTION: Cerebral Palsy (CP), the most common cause of disability in children, is phenotypically heterogeneous. Approximately 20% of cases develop severe scoliosis. A pathological hallmark of CP is periventricular leukomalacia (PVL), which is due to dysmyelination, suggesting the possibility of a lipidomic abnormality. Risk factors for CP include perinatal hypoxia, prematurity, multiple gestation, ischemia, infection, and maternal alcohol consumption. There is evidence for low serum levels of omega-3 (ω-3) fatty acids in CP patients, and separately in idiopathic scoliosis. Many effects of free fatty acids (FFAs) are mediated via specific G protein-coupled free fatty acid receptors (FFARs), which play essential …


Maternal Blood Lipid Biomarkers Of Oligodendrocyte Pathology To Predict Fetal Alcohol Spectrum Disorders, Nune Darbinian, Emily C Sparks, Armine Darbinyan, Nana Merabova, Gabriel Tatevosian, Ekaterina Vadachkoria, Huaqing Zhao, Shohreh Amini, Laura Goetzl, Michael E Selzer Jan 2023

Maternal Blood Lipid Biomarkers Of Oligodendrocyte Pathology To Predict Fetal Alcohol Spectrum Disorders, Nune Darbinian, Emily C Sparks, Armine Darbinyan, Nana Merabova, Gabriel Tatevosian, Ekaterina Vadachkoria, Huaqing Zhao, Shohreh Amini, Laura Goetzl, Michael E Selzer

Faculty, Staff and Student Publications

INTRODUCTION: Up to 9.9% of children have fetal alcohol spectrum disorders (FASD), the most frequent cause of intellectual disability in the US. FASD may involve abnormal brain development, including dysmyelination, suggesting abnormal development of oligodendrocytes (OLs), which make myelin and are rich in lipids. Indeed, low serum levels of omega-3 fatty acids (ω-3) have been reported in FASD. Free fatty acids bind to specific receptors (FFARs). We have isolated cell type-specific fetal brain-derived exosomes (FB-E) from maternal blood and sampled their contents to search for lipid-related biomarkers that predict FASD.

METHODS: Blood samples were collected from two groups of pregnant …


Are Trauma Surgeons Prepared? A Survey Of Trauma Surgeons’ Disaster Preparedness Before And During The Covid-19 Pandemic, Jay Doucet, David V Shatz, Lewis J Kaplan, Eileen M Bulger, Jeannette Capella, Deborah A Kuhls, Mary Fallat, Kyle N Remick, Christopher Newton, Adam Fox, Randeep Jawa, John A Harvin, David P Blake, Marko Bukur, Jonathan Gates, James Ficke, Mark L Gestring, The American Association For Surgery Of Trauma Disaster Committee Jan 2023

Are Trauma Surgeons Prepared? A Survey Of Trauma Surgeons’ Disaster Preparedness Before And During The Covid-19 Pandemic, Jay Doucet, David V Shatz, Lewis J Kaplan, Eileen M Bulger, Jeannette Capella, Deborah A Kuhls, Mary Fallat, Kyle N Remick, Christopher Newton, Adam Fox, Randeep Jawa, John A Harvin, David P Blake, Marko Bukur, Jonathan Gates, James Ficke, Mark L Gestring, The American Association For Surgery Of Trauma Disaster Committee

Faculty, Staff and Student Publications

OBJECTIVE: US trauma centers (TCs) must remain prepared for mass casualty incidents (MCIs). However, trauma surgeons may lack formal MCI training. The recent COVID-19 pandemic drove multiple patient surges, overloaded Emergency Medical Services (EMS) agencies, and stressed TCs. This survey assessed trauma surgeons' MCI training, experience, and system and personal preparedness before the pandemic compared with the pandemic's third year.

METHODS: Survey invitations were emailed to all 1544 members of the American Association for the Surgery of Trauma in 2019, and then resent in 2022 to 1575 members with additional questions regarding the pandemic. Questions assessed practice type, TC characteristics, …


The Lifecourse Perspective Theory As A Strategy For Improving Maternal Mortality In Georgia, Joanne Chopak-Foss, Alisha Riggins Jan 2023

The Lifecourse Perspective Theory As A Strategy For Improving Maternal Mortality In Georgia, Joanne Chopak-Foss, Alisha Riggins

Georgia Public Health Association Annual Meeting & Conference

Background: Maternal mortality and morbidity outcomes in Georgia are among the highest in the United States, with women of color experiencing higher rates of morbidity and mortality compared to their White counterparts. Public health policies such as Medicaid expansion have been suggested as one method for improving maternal mortality. In addition, the Life Course Perspective or Theory approach to maternal and child health suggests a complex interplay of biological, behavioral, psychological and social protective factors contributes to health outcomes across the span of a person’s life.

Methods: Using the Lifecourse Theory Perspective/Theory along with current maternal health policies the presenters …


Colorectal Cancer Screening Behaviors Among Smoking And Non-Smoking Public Housing Residents In Georgia, Shakirah Clarke Jan 2023

Colorectal Cancer Screening Behaviors Among Smoking And Non-Smoking Public Housing Residents In Georgia, Shakirah Clarke

Georgia Public Health Association Annual Meeting & Conference

Background: Tobacco use doubles the risk of developing colorectal cancer (CRC). Early detection screening for CRC should begin at 50y of age and be repeated at least every 10y. African Americans have a higher incidence of colorectal cancer when compared to Georgia and national rates.

Methods: Anonymous surveys were given to public housing residents (majority AA, low-income, n=155) at five sites from the Augusta Housing Authority, with questions about smoking status and when their last colonoscopy was performed. Results from residents 50 years and older (n=91) were selected. Descriptive analysis and a chi-square test of independence was performed to examine …


Evolving Roles And Responsibilities Of Public Health, Allison Foster Jan 2023

Evolving Roles And Responsibilities Of Public Health, Allison Foster

Georgia Public Health Association Annual Meeting & Conference

Since 2008, over 10,000 public health professionals have become Certified in Public Health (CPH). Periodically, the NBPHE conducts a Job Task Analysis survey to gain an understanding of the roles and responsibilities of the public health workforce. With that information, the main areas of focus on the CPH exam are updated.

In the summer of 2022, the National Board of Public Health Examiners launched a newJob Task Analysis process. The comprehensive set of responses will demonstrate the scope of public health responsibilities on a region-by-region basis.

Current domains of the CPH exam are: Communications, Leadership, Law and Ethics, Public Health …


Marine And Human Environmental Factors Influence Vibrio Parahaemolyticus And Vibrio Vulnificus In Vitro Biofilm Processes On Plastics, Ryan Eric Leighton Jan 2023

Marine And Human Environmental Factors Influence Vibrio Parahaemolyticus And Vibrio Vulnificus In Vitro Biofilm Processes On Plastics, Ryan Eric Leighton

Theses and Dissertations

Marine bacteria often exist in biofilms as communities attached to surfaces, like plastic. Growing concerns exist regarding marine plastics acting as potential vectors of pathogenic Vibrio, especially in a changing climate. It has been generalized that Vibrio vulnificus and Vibrio parahaemolyticus often attach to plastic surfaces. Different strains of these Vibrios exist having different growth and biofilm forming properties. This work evaluated how temperature and strain variability affect V. parahaemolyticus and V. vulnificus biofilm formation and characteristics on glass (GL), low-density polyethylene (LDPE), polypropylene (PP), and polystyrene (PS). This work also evaluated how human body related factors like temperature, …


The Effect Of High-Speed Power Training On Physical Frailty In Older Adults: Effect Of A Visual-Guided Exercise Program In South Korean Rural Areas, Dong H. Yoon, Jin-Soo Kim, Su S. Hwang, Dong W. Lee, Wook Song Jan 2023

The Effect Of High-Speed Power Training On Physical Frailty In Older Adults: Effect Of A Visual-Guided Exercise Program In South Korean Rural Areas, Dong H. Yoon, Jin-Soo Kim, Su S. Hwang, Dong W. Lee, Wook Song

Research outputs 2022 to 2026

Objective. Exercise has been shown to be an effective intervention; the difficulty still lies in providing exercise programs to the older adults in rural areas. Therefore, this study aimed to examine the effects of a 12-week exercise program provided with visual guidelines (prerecorded video) on frailty among older adults in rural areas. Methods. Fifty participants (71.7 ± 4.9 years) from 5 different rural areas were recruited and divided into two groups: the exercise group (EX, n = 24 (male: 8, female: 18)) and the control group (CON, n = 26 (male: 7, female: 17)). With the commencement of the exercise …


How Racial Trauma Manifests In Black Women From Direct And Indirect Encounters With Police Brutality, Ashley Turner Jan 2023

How Racial Trauma Manifests In Black Women From Direct And Indirect Encounters With Police Brutality, Ashley Turner

Antioch University Dissertations & Theses

This phenomenological study explored Black women’s lived experiences with racial trauma stemming from direct and indirect encounters with police brutality. A total of nine participants living in Washington state participated in this study. They identified as Black, ciswomen, fluent in English, and at least 21-years-old. In-depth, semi-structured, qualitative interviews were conducted to explore participants’ experiences with police. Transcripts were analyzed using interpretative phenomenological analysis. The results consisted of the following five themes: (a) forms of police encounters, (b) influence of identity, (c) perceived reason for police brutality, (d) emotions stemming from police brutality, and (e) tactics to survive police interactions. …