Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

Public Health

Institution
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 9121 - 9150 of 12203

Full-Text Articles in Entire DC Network

Evaluasi Pelaksanaan Konseling Menyusui, Ika Murtiyarini, Dewi Marhaeni Diah Herawati, Irvan Afriandi Aug 2014

Evaluasi Pelaksanaan Konseling Menyusui, Ika Murtiyarini, Dewi Marhaeni Diah Herawati, Irvan Afriandi

Kesmas

Salah satu upaya pemerintah dalam meningkatkan pemberian ASI di Indonesia adalah dengan memberikan konseling menyusui di pelayanan kesehatan. Penelitian perlu dilakukan untuk mengevaluasi pelaksanaan konseling menyusui di Kota Jambi dengan mengeksplorasi komponen input, activity, output, dan outcome. Penelitian ini merupakan penelitian kualitatif menggunakan strategi studi kasus. Penelitian dilakukan di empat puskesmas Kota Jambi pada bulan Desember 2013 sampai dengan Februari 2014. Pengumpulan data dilakukan dengan studi dokumen, observasi pelaksanaan konseling menyusui dan sarana prasarana, wawancara mendalam, serta focus group discussion. Analisis data yang digunakan adalah analisis tematik. Hasil penelitian menunjukkan bahwa komponen input dan activity kurang optimal seperti kurangnya sumber …


Fertilitas Remaja Di Indonesia, Mugia Bayu Raharja Aug 2014

Fertilitas Remaja Di Indonesia, Mugia Bayu Raharja

Kesmas

Fertilitas remaja merupakan isu penting dari segi kesehatan dan sosial karena berhubungan dengan tingkat morbiditas serta mortalitas ibu dan anak. Tujuan penelitian adalah mempelajari faktor-faktor yang memengaruhi fertilitas remaja di Indonesia. Data yang digunakan adalah hasil Survei Demografi dan Kesehatan Indonesia tahun 2012 dengan unit analisis wanita usia subur yang termasuk dalam kategori usia remaja (15 - 19 tahun). Jumlah sampel sebanyak 6.927 responden. Analisis dilakukan dengan metode deskriptif dan inferensial menggunakan model regresi logistik biner. Hasil analisis menunjukkan bahwa satu dari sepuluh remaja wanita tersebut pernah melahirkan dan atau sedang hamil saat survei dilakukan; sebesar 95,2% dari remaja yang …


Global School-Based Childhood Obesity Interventions: A Review, Melinda J. Ickes, Jennifer Mcmullen, Taj Haider, Manoj Sharma Aug 2014

Global School-Based Childhood Obesity Interventions: A Review, Melinda J. Ickes, Jennifer Mcmullen, Taj Haider, Manoj Sharma

Kinesiology and Health Promotion Faculty Publications

Background: The issue of childhood overweight and obesity has become a global public health crisis. School-based interventions have been developed and implemented to combat this growing concern. The purpose of this review is to compare and contrast U.S. and international school-based obesity prevention interventions and highlight efficacious strategies.

Methods: A systematic literature review was conducted utilizing five relevant databases. Inclusion criteria were: (1) primary research; (2) overweight or obesity prevention interventions; (3) school-based; (4) studies published between 1 January 2002 through 31 December 2013; (5) published in the English language; (6) child-based interventions, which could include parents; and …


Three-Year Change In The Wellbeing Of Orphaned And Separated Children In Institutional And Family-Based Care Settings In Five Low- And Middle-Income Countries, Kathryn Whetten, Jan Ostermann, Brian W. Pence, Rachel A. Whetten, Lynne C. Messer, Sumedha Ariely, Karen O'Donnell, Augustine I. Wasonga, Vanroth Vann, Dafrosa Itemba, Misganaw Eticha, Ira Madan, Nathan M. Thielman, The Positive Outcomes For Orphans (Pofo) Research Team Aug 2014

Three-Year Change In The Wellbeing Of Orphaned And Separated Children In Institutional And Family-Based Care Settings In Five Low- And Middle-Income Countries, Kathryn Whetten, Jan Ostermann, Brian W. Pence, Rachel A. Whetten, Lynne C. Messer, Sumedha Ariely, Karen O'Donnell, Augustine I. Wasonga, Vanroth Vann, Dafrosa Itemba, Misganaw Eticha, Ira Madan, Nathan M. Thielman, The Positive Outcomes For Orphans (Pofo) Research Team

Faculty Publications

Background With more than 2 million children living in group homes, or “institutions”, worldwide, the extent to which institution-based caregiving negatively affects development and wellbeing is a central question for international policymakers.

Methods A two-stage random sampling methodology identified community representative samples of 1,357 institution-dwelling orphaned and separated children (OSC) and 1,480 family-dwelling OSC aged 6–12 from 5 low and middle income countries. Data were collected from children and their primary caregivers. Survey-analytic techniques and linear mixed effects models describe child wellbeing collected at baseline and at 36 months, including physical and emotional health, growth, cognitive development and memory, and …


Childhood Obesity Fieldwork Summary Report: The Food Education Project, Maria De Rosario Vasquez Aug 2014

Childhood Obesity Fieldwork Summary Report: The Food Education Project, Maria De Rosario Vasquez

Master's Projects and Capstones

Childhood Obesity and diabetes is on the rise and the health risk for developing various diseases is a major public health issue. This paper examines the public health issue on childhood obesity and diabetes. This paper explains the importance and magnitude of this problem by providing statistics, research efforts, educational efforts and the importance of preventing childhood obesity and diabetes. The paper will summarize, explain observations and provide insight on fieldwork completed through a project called The Food Education Project. The project focuses on addressing the major public health problem through educating children and adolescents on health, nutrition, food and …


Three-Year Change In The Wellbeing Of Orphaned And Separated Children In Institutional And Family-Based Care Settings In Five Low- And Middle-Income Countries, Kathryn Whetten, Jan Ostermann, Brian W. Pence, Rachel A. Whetten, Lynne C. Messer, Sumedha Ariely, Karen O'Donnell, Augustine L. Wasonga, Vanroth Vann, Dafrosa Itemba, Misganaw Eticha, Ira Madan, Nathan M. Thielman, Positive Outcomes For Orphans (Pofo) Research Team Aug 2014

Three-Year Change In The Wellbeing Of Orphaned And Separated Children In Institutional And Family-Based Care Settings In Five Low- And Middle-Income Countries, Kathryn Whetten, Jan Ostermann, Brian W. Pence, Rachel A. Whetten, Lynne C. Messer, Sumedha Ariely, Karen O'Donnell, Augustine L. Wasonga, Vanroth Vann, Dafrosa Itemba, Misganaw Eticha, Ira Madan, Nathan M. Thielman, Positive Outcomes For Orphans (Pofo) Research Team

Community Health Faculty Publications and Presentations

Background: With more than 2 million children living in group homes, or "institutions", worldwide, the extent to which institution-based caregiving negatively affects development and wellbeing is a central question for international policymakers.

Methods: A two-stage random sampling methodology identified community representative samples of 1,357 institutional dwelling orphaned and separated children (OSC) and 1,480 family-dwelling OSC aged 6–12 from 5 low and middle income countries. Data were collected from children and their primary caregivers. Survey-analytic techniques and linear mixed effects models describe child wellbeing collected at baseline and at 36 months, including physical and emotional health, growth, cognitive development and memory, …


Nutrition Education And Community Advocacy At Marin Health And Human Services, Anna C. Allison Aug 2014

Nutrition Education And Community Advocacy At Marin Health And Human Services, Anna C. Allison

Master's Projects and Capstones

It would be a mistake to assume that all Marin neighborhoods look the same. The life expectancy in Ross is over 88 years. Less than 10 miles away in Hamilton Novato, the life expectancy is 75 years. That is a 13 year difference in life expectancy, roughly equivalent to the difference between living in the United States and Guyana. Marin is a small county, but it holds a great deal of variation. An effective health intervention in one neighborhood will not work in another, more importantly, there may not be the same health issue from one neighborhood to the next. …


County Of San Mateo Adolescent Report 2014-2015 Youth And Adults Working Together For A Healthy Future, Vanessa D. Bolton Aug 2014

County Of San Mateo Adolescent Report 2014-2015 Youth And Adults Working Together For A Healthy Future, Vanessa D. Bolton

Master's Projects and Capstones

The purpose of this paper is to highlight my fieldwork experience with the County of San Mateo Health System’s Health Policy and Planning Unit. Under the guidance of a Community Health Planner, my scope of work was within the area of school wellness, ranging from an adolescent report publication to researching breakfast in the classroom models to attending district wellness policy meetings. The San Mateo County Adolescent Report took precedence over most of the school wellness projects and initiatives because it was seeking to identify the needs of the County’s youth using evidence from various data sources and to develop …


Reducing Obesity And Obesity-Related Diseases In Richmond, California: Understanding The Importance Of Partnerships In Community-Based Health Education, Arlette Hernandez Aug 2014

Reducing Obesity And Obesity-Related Diseases In Richmond, California: Understanding The Importance Of Partnerships In Community-Based Health Education, Arlette Hernandez

Master's Projects and Capstones

In the United States obesity has become a major public health issue. Over the past two decades, the prevalence of obesity has doubled in adults and children. In the city of Richmond, California, adults and children are experiencing the highest rates of obesity and obesity-related diseases in comparison to other residents of West Contra Costa County. In an effort to reduce the rates of obesity in Richmond, two non-profit organizations have partnered up to provide innovative community-based health education to combat obesity and type II diabetes.

This paper will explore and summarize the 300-hour fieldwork the author experienced and completed …


Fieldwork Summary Report: Reducing Repeat Teenage Pregnancy Through Program Planning And Evaluation, Winnie Y. Chan Aug 2014

Fieldwork Summary Report: Reducing Repeat Teenage Pregnancy Through Program Planning And Evaluation, Winnie Y. Chan

Master's Projects and Capstones

This fieldwork summary report provides a synthesis of both my overall fieldwork experience at TAPP, Felton Institute’s Teenage Pregnancy and Parenting Program, and my Master of Public Health knowledge and skill sets. Since researching the huge social and economic impact that teenage pregnancy and parenting has not only on the teens and their children, but also the society at large, I strived to highlight prevention aspects to reduce repeat unwanted teenage pregnancy. So, I chose to intern at TAPP, focused my fieldwork project mainly on program development and evaluation, along with other aspects of improving wellness.

I begin this report …


Discovering Community Assets: Master Of Public Health Culminating Experience, Megan E. Sirna Aug 2014

Discovering Community Assets: Master Of Public Health Culminating Experience, Megan E. Sirna

Master's Projects and Capstones

The Sonoma County Department of Health Services, through Cradle to Career, promotes collective impact around educational attainment and workforce development, and has become a leader in developing a framework for community schools. The first step in developing a community schools model is to understand and inventory what is already going on in the community. This process, known more formally as asset mapping, is a participatory process focused on documenting the strengths and resources of a community. The collaborative nature of the process helps to promote community involvement and build community cohesion. In order to assist schools wanting to begin an …


The Development, Implementation, And Testing Of An Interactive Sexual Health Web-Based Application Intervention To Reduce Sexual Risk Behaviors Among College Students, Dawnyéa Dominique Jackson Aug 2014

The Development, Implementation, And Testing Of An Interactive Sexual Health Web-Based Application Intervention To Reduce Sexual Risk Behaviors Among College Students, Dawnyéa Dominique Jackson

Theses and Dissertations

College life is often regarded as a time for exploration and growth. One major area of exploration and growth for college students is sex and sexuality. Growth and exploration involves not only learning how to master these life situations, but also experiencing some negative consequences. Negative consequences for college students engaging in sexual risk-taking behaviors often lead to a high prevalence of sexually transmitted infections (STIs), unintended pregnancies, emotional distress, and large healthcare costs. Given the high prevalence of risky sexual behavior among young adults and the highly negative consequences of risky sexual behavior for this population, it is critical …


Role Of Chronic Inflammation On Liver Function During Cachexia Progression In The ApcMin/+ Mouse Model, Aditi Narsale Aug 2014

Role Of Chronic Inflammation On Liver Function During Cachexia Progression In The ApcMin/+ Mouse Model, Aditi Narsale

Theses and Dissertations

Cachexia is a multifactorial syndrome that manifests during the advanced stage of chronic diseases and is characterized by a progressive loss of body mass sustained by underlying inflammation. The ApcMin/+ mouse is an established model of cachexia that exhibits a gradual loss of body mass correlating with increasing tumor burden and plasma IL – 6 levels. Moreover it also mimics other secondary characteristics observed in cachectic patients like splenomegaly, elevated plasma endotoxin levels, gut barrier dysfunction, hypogonadism and an overall hypermetabolic state. Liver controls the energy metabolism in the body by regulating glucose and lipid metabolism, glycogen storage, filtration of …


Dietary Inflammatory Index And Its Relationship With Inflammation, Metabolic Biomarkers And Mortality, Nitin Shivappa Aug 2014

Dietary Inflammatory Index And Its Relationship With Inflammation, Metabolic Biomarkers And Mortality, Nitin Shivappa

Theses and Dissertations

Background: Diet and its components are known to play an important factor in the process of inflammation and in turn on the health effects that are related to inflammation like cancer, and cardiovascular diseases. Previous research so far has mainly looked at the effect of specific food or nutrients on inflammation and health outcomes. In this regard a new literature derived and population based dietary index called Dietary Inflammatory Index (DII) was developed after carefully screening around 6000 articles that looked at the association between 45 food parameters and 6 commonly studied inflammatory markers. The list of food parameters includes …


Longitudinal Changes In The Inflammatory Potential Of Diet And Risk Of Cancer In Women, Fred Kinyuytabung Aug 2014

Longitudinal Changes In The Inflammatory Potential Of Diet And Risk Of Cancer In Women, Fred Kinyuytabung

Theses and Dissertations

Introduction: The dietary inflammatory index (DII) assesses an individual’s overall diet quality with regards to its inflammatory potential on a continuum from maximally anti-inflammatory (lower or healthier DII scores) to maximally pro-inflammatory (higher or unhealthy DII scores). The DII measured at one point in time has been associated with cancer risk in previous studies; however, data are lacking regarding the change in DII over time and how these changes impact cancer risk. We assessed changes in the DII, and evaluated associations between cumulative history, and changes over time in dietary inflammatory potential, and risk of colorectal cancer (CRC) and breast …


Prediction Of Coronary Heart Disease Within The Aerobics Center Longitudinal Study Population, Jennifer Carol Gander Aug 2014

Prediction Of Coronary Heart Disease Within The Aerobics Center Longitudinal Study Population, Jennifer Carol Gander

Theses and Dissertations

This dissertation is a compilation of three studies that were conducted to better 1) Further validate a thoroughly tested Framingham Risk Score (FRS) on a unique cohort with comprehensive measures available, 2) Update and improve the predictability of the FRS through the addition of cardiorespiratory fitness (CRF) while resolving limitations in previous studies, and 3) Assess the predictability of non-exercise estimated CRF (e-CRF) and FRS on CHD. A manuscript was generated for each study utilizing data from the Aerobics Center Longitudinal Study.

To validate the FRS, a multivariable Cox Proportional Hazard Model was used to determine the association between FRS …


Understanding The Relationship Between Health Locus Of Control And God Locus Of Health Control And Health Behaviors In College Students Through Mediation Analysis, Joni Deann Marr Aug 2014

Understanding The Relationship Between Health Locus Of Control And God Locus Of Health Control And Health Behaviors In College Students Through Mediation Analysis, Joni Deann Marr

Theses and Dissertations

Background: Similar to the general population, college students have high rates of overweight/obesity and low rates of physical activity (PA) and healthy nutrition habits. Internal health locus of control (LOC) and religiosity/spirituality have been associated with positive health behaviors in various populations, but the mechanisms explaining these associations are still unclear. Purpose: The goals of this study were to understand the relationship between both health LOC and God locus of health control (independent variables) and PA, fruit and vegetable intake (FVI) and dietary fat intake (dependent variables) of college students through mediation analysis. Self-efficacy, social support, congregational social support and …


Association Of Serum Immunoglobulin G (Igg) Antibodies Against Periodontal Bacteria In Type 2 Diabetes And Pre-Diabetes And Cardiovascular Risk Factors, Deepika Shrestha Aug 2014

Association Of Serum Immunoglobulin G (Igg) Antibodies Against Periodontal Bacteria In Type 2 Diabetes And Pre-Diabetes And Cardiovascular Risk Factors, Deepika Shrestha

Theses and Dissertations

Periodontal disease is an inflammatory disease caused by polybacterial infection and inflammation plays key role that associates periodontal disease with different systemic diseases including diabetes and cardiovascular diseases. The main objective of this study is to evaluate and explore the association of serum IgG antibodies in four distinct clusters that were formed empirically from species specific 19 periodontal antibody titers with T2DM and pre-diabetes adjusting for known confounders such as age, sex, race-ethnicity, income to poverty ratio, education, smoking and drinking alcohol, BMI, WC, physical activity, missing teeth, dentist visits and other nutritional factors.

From the first aim, we formed …


A Study Of An Uncharacterized Penicillium Species Isolated From A Hypersaline Pond In San Salvador, Bahamas, Virginia Elizabeth Hopkins Aug 2014

A Study Of An Uncharacterized Penicillium Species Isolated From A Hypersaline Pond In San Salvador, Bahamas, Virginia Elizabeth Hopkins

Theses and Dissertations

A large number of facultative marine fungi are unexplored (Lai et al., 2007). They exist in the hypersaline environment with reduced growth and metabolism for an indeterminable period of time and are believed to have no ecological role. Here we report the discovery of one novel facultative Penicillium species that we named Penicillium virginium. We show that when transferred from its native ecosystem, a salt pond in San Salvador, Bahamas, to a laboratory fungal growth medium, Penicillium virginium demonstrates a higher growth rate in absence of salt than in presence of salt confirming that it is a facultative marine fungus. …


Fieldwork Summary Report-World Health Organization, Anna Cross Aug 2014

Fieldwork Summary Report-World Health Organization, Anna Cross

Master's Projects and Capstones

My fieldwork experience took place at the World Health Organization in Geneva, Switzerland, where I completed over 420 hours of practical experience. My fieldwork focused in the field of mental health, working on disorders management (psychosis, depression and suicide) and evidence-based research, but more specifically focusing on schizophrenia, premature death in severe mental disorders, and maternal mental health. Although my fieldwork focused within these areas, for the purpose of this final report, I have opted to focus on my contributions to the research around schizophrenia and premature death within severe mental disorders. Specifically, I contributed to multiple fact/information sheets for …


Developing A Community Health Worker Program In Chichigalpa, Nicaragua, Monterey Starkey Aug 2014

Developing A Community Health Worker Program In Chichigalpa, Nicaragua, Monterey Starkey

Other Graduate Research

The city of Chichigalpa, Nicaragua suffers from poor health that causes high rates of morbidity and mortality. Consequently, the people in Chichigalpa could be helped with better water solutions, nutritional status, and overall health knowledge. The people are poor and often do not have access to a doctor due to location or financial reasons. Therefore, a Community Health Program was created to train local community health workers to screen for diseases and to teach the local people preventive care, mainly focusing on water, nutrition, and CKDu. Objectives included assessing the community, recruiting community health workers, developing training curriculum, and training …


The Impact Of Preconception Maternal Stress On Fecundability And Adverse Pregnancy Outcomes., Shekufe Akhter Aug 2014

The Impact Of Preconception Maternal Stress On Fecundability And Adverse Pregnancy Outcomes., Shekufe Akhter

Electronic Theses and Dissertations

It has been commonly hypothesized (and widely believed) that maternal stress either prior to or during pregnancy can adversely affect fertility and pregnancy outcomes. However, surprisingly few epidemiologic studies have rigorously tested these hypotheses. The current study evaluated the effects of pre-conception self-reported stress on fecundability and spontaneous abortion. The study population was derived from the Mount Sinai Study of Woman Office Workers with 487 women included. Women recorded stress (scale from 1 to 4) and covariate information in a daily diary for 12 cycles or until pregnant. Results indicated a significantly increased risk of spontaneous abortion for women with …


30 Days On $200: A Cooking Guide For Tasty & Healthy Eating On A Budget, Benjamin J. Slocum Aug 2014

30 Days On $200: A Cooking Guide For Tasty & Healthy Eating On A Budget, Benjamin J. Slocum

Osteopathic Medicine Student Projects

Meal planning and cooking guide created to help people on food assistance and others better utilize their resources. This book contains health information, grocery shopping tips, meal planning guides, and easy instruction on cooking and the use of leftovers. With simple-to-read, image-based instruction, it teaches the basics on how to budget, plan meals, make shopping lists, and prepare food. The book assumes no prior cooking experience, and while anyone can benefit from the book regardless of income level, it makes a particular effort to demonstrate preparation for foods commonly acquired at food pantries.


Biomechanics And Ergonomics In Women Material Handlers, André Plamondon, Denys Denis, Christian Larivière, Alain Delisle, Denis Gagnon, Marie St-Vincent, Iuliana Nastasia Aug 2014

Biomechanics And Ergonomics In Women Material Handlers, André Plamondon, Denys Denis, Christian Larivière, Alain Delisle, Denis Gagnon, Marie St-Vincent, Iuliana Nastasia

Rapports de recherche scientifique

De nombreuses femmes exercent le métier de manutentionnaire. À tort, on a négligé de s’intéresser à cette population parce que le métier de manutentionnaire est largement pratiqué par des hommes. Il existe des études qui ont observé des différences significatives entre les hommes et les femmes dans leurs façons d’effectuer les tâches de manutention, mais leur nombre est limité. Quoique le nombre de manutentionnaires féminins soit beaucoup moins élevé dans certains types d’activité comme le transport et la machinerie, dans d’autres secteurs comme l’alimentation et les services, les femmes constituent souvent près de la moitié de la main-d'œuvre qui, de …


The Environmental And Health Costs Of Alternative Diets: A Comparative Study Of The U. S. Diet Relative To The French, Japanese, Mediterranean, And Nordic Diets, Sarah Rehkamp Aug 2014

The Environmental And Health Costs Of Alternative Diets: A Comparative Study Of The U. S. Diet Relative To The French, Japanese, Mediterranean, And Nordic Diets, Sarah Rehkamp

Department of Agricultural Economics: Dissertations, Theses, and Student Research

This thesis contributes to the literature on sustainable consumption by using scenario analysis to evaluate the environmental and health costs of the U.S. diet relative to the French, Japanese, Mediterranean, and Nordic diets, identified in the literature as healthier diets. As a first step in estimating environmental costs, the energy efficiencies of each diet are calculated by decomposing each of the diets into their respective components. Then, the dietary efficiencies are translated into CO2 emissions. As a first step in estimating health costs, a pooled cross-section time-series dataset is used to find the association between BMI and five countries, …


Influence Of Resources, Resource Loss, And Coping Response On Food Management Practices And Food Security, Simone Perette Camel Aug 2014

Influence Of Resources, Resource Loss, And Coping Response On Food Management Practices And Food Security, Simone Perette Camel

Dissertations

Food insecurity has been associated with compromised health and wellness. Current literature regarding coping strategies and practices employed by the food insecure often describes food management and acquisition practices, and/or the riskiness of these practices. Material and personal resources such as income, time, self-efficacy, and social support have been identified as predictors or influencers of food security status. In this study, the Conservation of Resources theory was used to conceptualize resources and resource loss as they relate to food practices and food security. It was hypothesized that the level of resources would influence food security status and the adaptive food …


Examining The Influence Of Farmers' Market Motivations On Access To Healthful Foods And Business Opportunities For Farms, Rachel K. Ward Aug 2014

Examining The Influence Of Farmers' Market Motivations On Access To Healthful Foods And Business Opportunities For Farms, Rachel K. Ward

Electronic Theses and Dissertations

Farmers’ markets are increasingly promoted as mechanisms for improving access to healthful foods for low-income households, as they are relatively inexpensive to establish and they can provide affordable food for low-income households by offering Supplemental Nutrition Assistance Program Electronic Benefit Transfer (SNAP/EBT). SNAP/EBT at markets also expands revenue opportunities for participating farmers. Market mangers provide a critical role in overseeing SNAP/EBT at markets and influencing business opportunities for farmers. Using a mixed-method approach, this study aimed to evaluate how managers’ motivations influence SNAP/EBT availability and participation at markets and business opportunities for small- and moderate- sized farms.

To develop a …


Novel Serum Biomarkers For Lung Cancer Early Diagnosis And Clinical Outcome, Fanmao Zhang Aug 2014

Novel Serum Biomarkers For Lung Cancer Early Diagnosis And Clinical Outcome, Fanmao Zhang

Dissertations and Theses (Open Access)

The five-year survival rate for all stages of lung cancer combined is only 17%, which has changed little over the past 40 years. Despite the tremendous efforts made, serum biomarkers with clinical utility for lung cancer early detection and clinical outcome prediction are still lacking. Metabolic alterations have been recognized as an emerging hallmark of cancer. We aimed to investigate the metabolic changes associated with lung cancer and to identify novel clinically applicable serum biomarkers for lung cancer early diagnosis and clinical outcome.

Serum metabolites are potential biomarkers for lung cancer early detection. We first performed global metabolomic profiling followed …


Genetic Predictors Of Metabolic Side Effects Of Diuretic Therapy, Jorge L. Del Aguila Aug 2014

Genetic Predictors Of Metabolic Side Effects Of Diuretic Therapy, Jorge L. Del Aguila

Dissertations and Theses (Open Access)

Thiazide diuretics are a recommended first-line monotherapy for hypertension (i.e.SBP>140 mmHg or DBP>90 mmHg). Even so, diuretics are associated with adverse metabolic side effects, such as hyperlipidemia, hyperglycemia and hypokalemia which increase the risk of developing type II diabetes. This thesis used three analytical strategies to identify and quantify genetic factors that contribute to the development of adverse metabolic effects due to thiazide diuretic treatment. I performed a genome-wide association study (GWAS) and meta-analysis of the change in fasting plasma glucose and triglycerides in response to HCTZ from two different clinical trials: the Pharmacogenomic Evaluation of Antihypertensive Responses …


Dispositional Optimism: Modeling Cardiovascular Disease Mortality With Traditional Risk Factors And A Psychosocial Personality Trait, Kiana Ramisi Luckett Robinson Aug 2014

Dispositional Optimism: Modeling Cardiovascular Disease Mortality With Traditional Risk Factors And A Psychosocial Personality Trait, Kiana Ramisi Luckett Robinson

Dissertations

Despite increased awareness of clinical risk factors for cardiovascular disease (CVD), heart disease remains a physical and economic burden to African Americans. The aim of this study was to investigate the relationship between dispositional optimism, a psychosocial personality trait, and CVD mortality, based on immediate cause of death. A cross-sectional design was used to examine the predictive value of dispositional optimism in CVD mortality concomitant with traditional CVD risk factors. The traditional CVD risk factors of interest consisted of body mass index, waist circumference, systolic and diastolic blood pressures, total cholesterol, and C-reactive protein. Also, aggregated mortality data for optimists …