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The Effect Of Intermediate Doses Of Roundup® On The Larval Development, Survival, Oviposition And Fitness Of Culex Quinquefasciatus, Abdoulaye Aziz Zerbo Aug 2024

The Effect Of Intermediate Doses Of Roundup® On The Larval Development, Survival, Oviposition And Fitness Of Culex Quinquefasciatus, Abdoulaye Aziz Zerbo

Electronic Theses, Projects, and Dissertations

The southern house mosquito, Culex quinquefasciatus, is a vector to many pathogens in Southern California, including West Nile Virus and St. Louis Encephalitis Virus. Immature stages of mosquitoes may be exposed to Roundup®, a frequently used herbicide worldwide, due to surface runoffs or overspraying and subsequent drifting. Previous studies have shown some negative impacts of sublethal doses of Roundup® during the developmental stage of Culex quinquefasciatus, such as physiologic changes and prolonged larval stage or the high mortality of larvae due to exposure to the high doses of glyphosate. This study investigated the effect of …


Emotional Eating In Adolescents With Obesity: Case Series, Paula Dayan Aug 2024

Emotional Eating In Adolescents With Obesity: Case Series, Paula Dayan

Electronic Theses, Projects, and Dissertations

Childhood obesity remains a significant public health concern, with substantial implications for physical and mental well-being. This thesis aims to explore the intricate relationship between emotional eating and obesity among adolescents, with a focus on identifying emotional triggers and assessing their psychological impact. Utilizing a cross-sectional study design at a university in southern California, data were collected from two adolescents aged 13-18 years. Through surveys and body composition measurements, participants' emotional barriers to weight loss and readiness for change were assessed. The findings underscore the presence of varying degrees of emotional hurdles among adolescents with obesity, including depression, frustration, and …


A Process Evaluation Plan For The Nebraska Fetal Infant Mortality Review (Fimr) Program, Mamello Makhele Aug 2024

A Process Evaluation Plan For The Nebraska Fetal Infant Mortality Review (Fimr) Program, Mamello Makhele

Capstone Experience: Master of Public Health

The United States (U.S.) has made substantial progress in reducing fetal and infant mortality, but high rates of infant mortality persist, particularly within minority populations. In Douglas County, Nebraska, racial disparities in infant mortality rates remain a significant issue. In 2019, the infant mortality rate among African American mothers was 14.2 infant deaths per 1,000 live births, compared to 5.7 infant deaths per 1,000 live births among Caucasian mothers.

To reduce fetal and infant mortality in the U.S., the Centers for Disease Control and Prevention along with the Human Resources and Services Administration, fund the Fetal and Infant Mortality Review …


Residential Street Trees And Cardiovascular Disease Among Urban-Dwelling Mexican Adults, Christine Campbell Aug 2024

Residential Street Trees And Cardiovascular Disease Among Urban-Dwelling Mexican Adults, Christine Campbell

Walden Dissertations and Doctoral Studies

Cardiovascular diseases (CVDs) are a significant public health burden in Mexico despite national efforts to address traditional risk factors. With growing evidence that elements of nature can improve physical and mental health of people living in cities, this quantitative epidemiological study of secondary data examined the relationship between the presence of street trees in Mexican metropolitan areas and self-reported CVD in adults over age 40. The integrated socio-environmental model of health and well-being provided the conceptual framework for the study. A secondary data analysis was performed using combined individual health data from Mexico’s 2012 National Health and Nutrition Survey and …


Expanding A Behavioral View On Digital Health Access: Drivers And Strategies To Promote Equity, Maura M Kepper, Lauren A Fowler, Isabelle S Kusters, Jean W Davis, Manal Baqer, Sara Sagui-Henson, Yunyu Xiao, Adati Tarfa, Jean C Yi, Bryan Gibson, Kristin E Heron, Nicole M Alberts, Marissa Burgermaster, Veronica Ps Njie-Carr, Lisa M Klesges Aug 2024

Expanding A Behavioral View On Digital Health Access: Drivers And Strategies To Promote Equity, Maura M Kepper, Lauren A Fowler, Isabelle S Kusters, Jean W Davis, Manal Baqer, Sara Sagui-Henson, Yunyu Xiao, Adati Tarfa, Jean C Yi, Bryan Gibson, Kristin E Heron, Nicole M Alberts, Marissa Burgermaster, Veronica Ps Njie-Carr, Lisa M Klesges

Center for Medical Ethics and Health Policy Staff Publications

The potential and threat of digital tools to achieve health equity has been highlighted for over a decade, but the success of achieving equitable access to health technologies remains challenging. Our paper addresses renewed concerns regarding equity in digital health access that were deepened during the COVID-19 pandemic. Our viewpoint is that (1) digital health tools have the potential to improve health equity if equitable access is achieved, and (2) improving access and equity in digital health can be strengthened by considering behavioral science-based strategies embedded in all phases of tool development. Using behavioral, equity, and access frameworks allowed for …


A Qualitative Exploration To Inform An Oral Health Training For Disability Care Workers In Burkina Faso, Ave Põld, Dan Filwendé Kientega, Jocelyne Valérie Garé, Michael Lorenz Aug 2024

A Qualitative Exploration To Inform An Oral Health Training For Disability Care Workers In Burkina Faso, Ave Põld, Dan Filwendé Kientega, Jocelyne Valérie Garé, Michael Lorenz

Faculty, Staff and Student Publications

AIM: To explore enablers and barriers to the creation of an oral health training for care workers at specialized centres for children with disabilities in Ouagadougou.

DESIGN: This was a formative study informed by the Theoretical Domains Framework using qualitative methods.

METHODS: Qualitative observations and 14 semi-structured interviews were conducted with care workers from six specialized centres for disability.

RESULTS: Carer workers emphasized that a successful oral health training must account for available resources and competencies in each specific centre. Part of the training must be dedicated to oral hygiene targeted for people with disabilities and provide knowledge about risk …


Mechanisms Of Neurodevelopmental Toxicity Of Topiramate, John W Steele, Vaishnav Krishnan, Richard H Finnell Aug 2024

Mechanisms Of Neurodevelopmental Toxicity Of Topiramate, John W Steele, Vaishnav Krishnan, Richard H Finnell

Faculty, Staff and Students Publications

Prescriptions for antiseizure medications (ASMs) have been rapidly growing over the last several decades due, in part, to an expanding list of clinical indications for which they are now prescribed. This trend has raised concern for potential adverse neurodevelopmental outcomes in ASM-exposed pregnancies. Recent large scale population studies have suggested that the use of topiramate (TOPAMAX, Janssen-Cilag), when prescribed for seizure control, migraines, and/or weight management, is associated with an increased risk for autism spectrum disorder (ASD), intellectual disability, and attention-deficit/hyperactivity disorder (ADHD) in exposed offspring. Here, we critically review epidemiologic evidence demonstrating the neurobehavioral teratogenicity of topiramate and speculate …


Smoking Habit At Home And Upper Respiratory Infection In Infants Aged 6-12 Months, Musfardi Rustam, Nur Pelita Sembiring, Taswir Effendy Jul 2024

Smoking Habit At Home And Upper Respiratory Infection In Infants Aged 6-12 Months, Musfardi Rustam, Nur Pelita Sembiring, Taswir Effendy

Kesmas

Upper Respiratory Tract Infection (URI) is an acute infection caused by viruses, fungi, and bacteria. Smoking habit at home is a risk factor for URI in infants. This study aimed to determine a relationship between smoking at home and the incidence of URI in infants. This study was conducted the fourth week of February 2010 until the third week of April 2010 in Kampar District, Indonesia. This analytical study used a case-control design and cluster random sampling. The samples comprised 162 cases and 162 controls, infants aged 6-12 months. The cases were 162 infants aged 6-12 months suffering from URI …


Hubungan Konsumsi Ttd Pada Ibu Hamil Dengan Kejadian Bblr Di Indonesia: Systematic Literature Review, Miftahun Najah, Budi Utomo, Syafira Anindya Dhika Maulani, Hafshah Farah Fadhilah, Sofiyulloh Sofiyulloh, Yuniko Ibnu Latif Jul 2024

Hubungan Konsumsi Ttd Pada Ibu Hamil Dengan Kejadian Bblr Di Indonesia: Systematic Literature Review, Miftahun Najah, Budi Utomo, Syafira Anindya Dhika Maulani, Hafshah Farah Fadhilah, Sofiyulloh Sofiyulloh, Yuniko Ibnu Latif

Jurnal Biostatistik, Kependudukan, dan Informatika Kesehatan

Berat bayi lahir rendah (BBLR) merupakan masalah kesehatan masyarakat yang masih signifikan secara global hingga saat ini. Diperkirakan 15-20% dari seluruh kelahiran di seluruh dunia adalah BBLR. Salah satu penyebab BBLR adalah anemia defisiensi zat besi pada ibu hamil. Penelitian ini bertujuan untuk meninjau literatur secara sistematik dengan menelaah hasil penelitian artikel-artikel sebelumnya. Penelitian menggunakan metode systematic review dengan pendekatan kuantitatif . Penelusuran artikel mengunakan tiga database seperti ProQuest, Scopus dan Google Scholar dengan menggunakan kata kunci “zat besi, “tablet tambah darah”, “berat bayi lahir rendah”, “BBLR”, “Indonesia” dan menggunakan PRISMA mencakup identifikasi, skrining, eligibilitas dan sintesis. Artikel harus memenuhi …


Passive Smoking And Its Correlation With Stunting In Children: A Systematic Review, Anita Rahmiwati, Karlinda Karlinda, Hamzah Hasyim, Febriyansyah Febriyansyah Jul 2024

Passive Smoking And Its Correlation With Stunting In Children: A Systematic Review, Anita Rahmiwati, Karlinda Karlinda, Hamzah Hasyim, Febriyansyah Febriyansyah

Kesmas

Passive smoking is a significant risk factor for stunting in children, highlighting the urgent need for effective public health measures. This study aimed to investigate the association between passive smoking and stunting in children aged 0 months-7 years. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a comprehensive literature search was conducted across multiple online databases, including PubMed, ProQuest, Science Direct, Willey Online Library, Sage Journal, Cambridge University Press, and Oxford Academic. The quality of included articles reporting observational studies was assessed using the Critical Appraisal Skill Programme (CASP) checklist, presenting data through narrative synthesis. Findings …


Examining The Relationship Between Shift Work And Diabetes Mellitus Among Nurses: An Evidence-Based Case Report, Angga Arifianto, Indah Suci Widyahening, Levina Chandra Khoe, M. Ikhsan Mokoagow Jul 2024

Examining The Relationship Between Shift Work And Diabetes Mellitus Among Nurses: An Evidence-Based Case Report, Angga Arifianto, Indah Suci Widyahening, Levina Chandra Khoe, M. Ikhsan Mokoagow

Occupational and Environmental Medicine Journal of Indonesia

Background : Work shifts could cause numerous health problems, such as sleep disorders, weight gain disorders, and unhealthy food intake consumption, leading to obesity and changes in blood glucose levels, that eventually lead to diabetes mellitus. This evidence-based case report aims to provide an evidence of association between shift work and the risk of diabetes mellitus among nurses.

Methods : We performed a literature searching from Pubmed, Embase, Cochrane, Scopus, and Google Scholar in September 2023 using keywords ‘shift work’ AND ‘diabetes’ AND ‘nurse’. We included studies that assessed the association between shift work and diabetes among nurses using observational …


Systematic Review Of Factors Related To Pm2.5 Exposure On The Risk Of Type 2 Diabetes Mellitus, Rifka Putri Salma, Laila Fitria Jul 2024

Systematic Review Of Factors Related To Pm2.5 Exposure On The Risk Of Type 2 Diabetes Mellitus, Rifka Putri Salma, Laila Fitria

Kesmas

Diabetes mellitus is a major public health problem in many countries, and most of them are type 2 diabetes mellitus (T2DM). Air pollution is thought to contribute to the T2DM incidence, and one of the most important pollutants is PM2.5. This study aimed to determine factors related to PM2.5 exposure and individual factors in increasing the risk of T2DM based on a systematic review. The PRISMA was used as a method of data collection and selection. Of 176 relevant articles identified and screened, 12 articles from various countries published in 2013-2021 were synthesized in this study. Results showed that long-term …


Health And Environmental Pollution: A Literature Review, Elsa Yuniarti, Levi Anatolia S.M. Exposto, Indang Dewata, Fitra Arya Dwi Nugraha, Alfitri Alfitri Jul 2024

Health And Environmental Pollution: A Literature Review, Elsa Yuniarti, Levi Anatolia S.M. Exposto, Indang Dewata, Fitra Arya Dwi Nugraha, Alfitri Alfitri

Kesmas

This study aimed to review various studies focusing on pollution that could adversely affect health, including sources, types, and mitigation efforts. The data used were obtained through a search on the Scopus website using the keywords "Health" AND "Pollution" from 2016 to 2023. Using these two keywords, 72 titles and abstracts of papers were successfully found. The results of this literature review were then analyzed with the assistance of NVivo 12 Pro, which grouped the findings based on their impact on health, reasons for pollution, types of pollution, and preventive measures. It was identified that the most common disease was …


Capitation Management Through Performance-Based Capitation Mechanism Of Primary Health Care In Malang, Indonesia, Ayu Tyas Purnamasari, Herlinda Dwi Ningrum, Anggi Ardhiasti, Asri Hikmatuz Zahroh Jul 2024

Capitation Management Through Performance-Based Capitation Mechanism Of Primary Health Care In Malang, Indonesia, Ayu Tyas Purnamasari, Herlinda Dwi Ningrum, Anggi Ardhiasti, Asri Hikmatuz Zahroh

Kesmas

Primary health care (PHC) has one of the largest funding sources, capitation, which BPJS Healthcare Security transfers monthly. Capitation fund receipts were frequently insufficient due to failure to meet performance-based capitation/Kapitasi Berbasis Kinerja (KBK) targets, including for PHC in Malang City, Indonesia. This study aimed to examine the management and utilization of capitation funds through a KBK mechanism. This descriptive study used a qualitative approach supported by quantitative data. This study was conducted from July to August 2023 and purposely selected nine informants from BPJS Healthcare Security, the local health office, and PHC. The interviews were transcribed verbatim and analyzed …


Economic Loss Of Leptospirosis: Is It Still Appropriate To Be Tropical Neglected Zoonosis Disease?, Wahyu Pudji Nugraheni, Sinta Dewi Lestyoningrum, Ristiyanto Ristiyanto, Wahyu Gito Putro, Indah Pawitaningtyas, Syarifah Nuraini, Linta Meyla Putri, Debri Rizki Faisal, Adhista Eka Noveyani, Muhammad Agus Mikrajab Jul 2024

Economic Loss Of Leptospirosis: Is It Still Appropriate To Be Tropical Neglected Zoonosis Disease?, Wahyu Pudji Nugraheni, Sinta Dewi Lestyoningrum, Ristiyanto Ristiyanto, Wahyu Gito Putro, Indah Pawitaningtyas, Syarifah Nuraini, Linta Meyla Putri, Debri Rizki Faisal, Adhista Eka Noveyani, Muhammad Agus Mikrajab

Kesmas

Leptospirosis is a tropical endemic disease that can reduce the productivity of sufferers. However, research on economic and productivity losses due to leptospirosis is rare. This study aimed to determine economic and productivity losses due to leptospirosis in the Banyumas District, Indonesia, as an endemic area. This study used a cross-sectional design and quantitative methods conducted in October 2022. Secondary data of medical records and billing information from 73 inpatients receiving treatment at a Public Hospital in the Banyumas District from February 2021 to September 2022 obtained from the hospital’s archives were used. This study examined the actual costs (direct …


New Approach To Mapping Regional Vulnerability In Controlling Tuberculosis Disease In Indonesia, Maria Holly Herawati, Asep Hermawan, Dasuki Dasuki, Hadi Supratikta, Al Asyary, M Rokhis Khomarudin, Muhammad Priyatna, Raflizar Raflizar, Kristina Kristina, Noer Endah Pracoyo, Dina Bisara, Cahya Tri Purnami, Mentari Nur Farida Suteja, Yusrial Bachtiar, Noor Edi Widya Sukoco, Doni Lasut Jul 2024

New Approach To Mapping Regional Vulnerability In Controlling Tuberculosis Disease In Indonesia, Maria Holly Herawati, Asep Hermawan, Dasuki Dasuki, Hadi Supratikta, Al Asyary, M Rokhis Khomarudin, Muhammad Priyatna, Raflizar Raflizar, Kristina Kristina, Noer Endah Pracoyo, Dina Bisara, Cahya Tri Purnami, Mentari Nur Farida Suteja, Yusrial Bachtiar, Noor Edi Widya Sukoco, Doni Lasut

Kesmas

Tuberculosis (TB) in Indonesia is still a health problem. The TB prevalence in Indonesia ranks second in the world after India in 2023. Regional factors, inadequate healthcare facilities, and limited resources (financial, human, and infrastructure) are challenges requiring innovation to help the government control TB. TB eradication efforts need to be made with a comprehensive and effective approach. One method used is to look at the vast territory of Indonesia, therefore, mapping the TB disease vulnerability is a highly recommended method. The use of a Geographic Information System is expected to help map the TB vulnerability areas in Indonesia. Given …


Maternal Decision Making And Children’S Nutritional Status: Evidence From Indonesia, Nadia Roswita, Teguh Dartanto Jul 2024

Maternal Decision Making And Children’S Nutritional Status: Evidence From Indonesia, Nadia Roswita, Teguh Dartanto

Jurnal Ekonomi Kependudukan dan Keluarga

Indonesia is encountering consecutive health problems caused by malnutrition. The latter poses long-term effects on children’s development. As this issue continue its prominence, using linear regression and binary logistic with time lag to analyze data from Indonesia Family Life Survey (IFLS) in 2007 and 2014 shall support the analysis of issue. Previous results from the models indicated that maternal decision-making in their share of food expenditure has a weak correlation for stunted children's experience. However, this study revealed different results. It suggested that involvement in from men in nutritional knowledge, skills, and financial backing to advance women's roles contributes to …


Pengaruh Karakteristik Rumah Tangga Terhadap Kejadian Kematian Maternal Di Pulau Papua, Intan Putri Utami, Yuliagnis Transver Wijaya Jul 2024

Pengaruh Karakteristik Rumah Tangga Terhadap Kejadian Kematian Maternal Di Pulau Papua, Intan Putri Utami, Yuliagnis Transver Wijaya

Jurnal Ekonomi Kependudukan dan Keluarga

Maternal health and life during pregnancy, childbirth, and the postpartum period are very important in determining the growth and future development of the birth generation. SDG indicators express the global seriousness of this effort, aiming to reduce the maternal mortality ratio (MMR) to less than 70 per 100,000 live births by 2030. However, according to the Long Form SP2020, Indonesia still has 189 deaths per 100,000 live births. Papua and West Papua are the two provinces with the worst MMR achievements, with 565 and 343 deaths per 100,000 live births, respectively. Therefore, this research will provide general overview and identify …


Mckenzie Exercise For Reducing Low Back Pain Complaints In Office Worker: An Evidence-Based Case Report, Bonnie Medana Pahlavie, Dewi S. Soemarko, Indah Suci Widyahening Jul 2024

Mckenzie Exercise For Reducing Low Back Pain Complaints In Office Worker: An Evidence-Based Case Report, Bonnie Medana Pahlavie, Dewi S. Soemarko, Indah Suci Widyahening

Occupational and Environmental Medicine Journal of Indonesia

Background:

Low back pain (LBP) is pain that is felt in the lower back area, namely between the corners of the lowest ribs and the lower buttocks (lumbar or lumbo-sacral area) and can be local pain or radiate to the upper thighs/legs or both. Low back pain is a 10% debilitating condition that results in a change in life expectancy due to disability. Low back pain is not a malignancy and is a self-limiting condition, but patients always seek treatment to reduce the severity of their symptoms. Chronic Low Back Pain can alter lifestyle and increase the rate of prolonged …


Development And Validity Of The 'Modified Mediterranean Prime Screen' To Assess Dietary Intake Among Women Of Reproductive Age In Lebanon, Mariam Assaad, Sara Ajjour, Maya Rahme, Laila Al-Shaar, May Sakr, Hala Ghattas Ph.D., Ghada El-Hajj Fuleihan, Jana Jabbour Jul 2024

Development And Validity Of The 'Modified Mediterranean Prime Screen' To Assess Dietary Intake Among Women Of Reproductive Age In Lebanon, Mariam Assaad, Sara Ajjour, Maya Rahme, Laila Al-Shaar, May Sakr, Hala Ghattas Ph.D., Ghada El-Hajj Fuleihan, Jana Jabbour

Faculty Publications

The Mediterranean Region registers an increasing prevalence of obesity. The region lacks a diet screener to assess obesogenic nutrients. This study aimed to evaluate the reproducibility and validity of the Modified Mediterranean Prime Screen (MMPS) in estimating obesogenic nutrients' intake among women of reproductive age, as compared with a culturally validated Food Frequency Questionnaire (FFQ), in Lebanon. We developed the MMPS consisting of thirty-two food/beverage items specific to the Lebanese Mediterranean culture. The MMPS and FFQ were administered in two visits (2 weeks-6 months apart), face to face and via telephone during the coronavirus disease 2019 pandemic. The reproducibility and …


Selection For Robust Metabolism In Domesticated Yeasts Is Driven By Adaptation To Hsp90 Stress, Natalia Condic, Hatim Amiji, Dipak Patel, William Charles Shropshire, Nejla Ozirmak Lermi, Youssef Sabha, Beryl John, Blake Hanson, Georgios Ioannis Karras Jul 2024

Selection For Robust Metabolism In Domesticated Yeasts Is Driven By Adaptation To Hsp90 Stress, Natalia Condic, Hatim Amiji, Dipak Patel, William Charles Shropshire, Nejla Ozirmak Lermi, Youssef Sabha, Beryl John, Blake Hanson, Georgios Ioannis Karras

Faculty, Staff and Student Publications

Protein folding both promotes and constrains adaptive evolution. We uncover this surprising duality in the role of the protein-folding chaperone heat shock protein 90 (Hsp90) in maintaining the integrity of yeast metabolism amid proteotoxic stressors within industrial domestication niches. Ethanol disrupts critical Hsp90-dependent metabolic pathways and exerts strong selective pressure for redundant duplications of key genes within these pathways, yielding the classical genomic signatures of beer and bread domestication. This work demonstrates a mechanism of adaptive canalization in an ecology of major economic importance and highlights Hsp90-dependent variation as an important source of phantom heritability in complex traits.


Sociocultural Effects On Suicidal Ideation Among South Asian Immigrants, Rezwana Ahmed Choudhury Jul 2024

Sociocultural Effects On Suicidal Ideation Among South Asian Immigrants, Rezwana Ahmed Choudhury

Walden Dissertations and Doctoral Studies

With the growing South Asian immigrant population in the West, it is necessary to conduct suicide-related studies among this population to understand the reasons behind suicidal ideation faced by this population. This quantitative cross-sectional survey design study aimed to examine sociocultural factors that may be associated to the risk level of suicidal ideation among South Asian immigrants in the United States. A survey questionnaire was developed using a combination of demographic questions and existing instruments: the Suicide Ideation Attributes Scale, Religious Belief Salience Scale, Suinn-Lew Asian Self-Identity Acculturation Scale, and Rapid Eating Assessment for Participants—S. Data were collected from a …


A Light-Responsive Neural Circuit Suppresses Feeding, Hailan Liu, Na Qu, Natalia Valdez Gonzalez, Marco A Palma, Huamin Chen, Jiani Xiong, Abhinav Choubey, Yongxiang Li, Xin Li, Meng Yu, Hesong Liu, Longlong Tu, Nan Zhang, Na Yin, Kristine Marie Conde, Mengjie Wang, Jonathan Carter Bean, Junying Han, Nikolas Anthony Scarcelli, Yongjie Yang, Kenji Saito, Huxing Cui, Qingchun Tong, Zheng Sun, Chunmei Wang, Xing Cai, Li Lu, Yang He, Yong Xu Jul 2024

A Light-Responsive Neural Circuit Suppresses Feeding, Hailan Liu, Na Qu, Natalia Valdez Gonzalez, Marco A Palma, Huamin Chen, Jiani Xiong, Abhinav Choubey, Yongxiang Li, Xin Li, Meng Yu, Hesong Liu, Longlong Tu, Nan Zhang, Na Yin, Kristine Marie Conde, Mengjie Wang, Jonathan Carter Bean, Junying Han, Nikolas Anthony Scarcelli, Yongjie Yang, Kenji Saito, Huxing Cui, Qingchun Tong, Zheng Sun, Chunmei Wang, Xing Cai, Li Lu, Yang He, Yong Xu

Faculty, Staff and Students Publications

Light plays an essential role in a variety of physiological processes, including vision, mood, and glucose homeostasis. However, the intricate relationship between light and an animal's feeding behavior has remained elusive. Here, we found that light exposure suppresses food intake, whereas darkness amplifies it in male mice. Interestingly, this phenomenon extends its reach to diurnal male Nile grass rats and healthy humans. We further show that lateral habenula (LHb) neurons in mice respond to light exposure, which in turn activates 5-HT neurons in the dorsal Raphe nucleus (DRN). Activation of the LHb→5-HTDRN circuit in mice blunts darkness-induced hyperphagia, while inhibition …


Do Apoe4, Malnutrition, And Long Covid-19 Compound The Risk Factors For Stroke In Adverse Environments?, Alexander Vasconcelos Buzaglo, Carlos Meton De Alencar Gadelha Vieira, Gabriella Cunha Vieira Ciurleo, Ludmila Belayev, Reinaldo B. Oriá Jul 2024

Do Apoe4, Malnutrition, And Long Covid-19 Compound The Risk Factors For Stroke In Adverse Environments?, Alexander Vasconcelos Buzaglo, Carlos Meton De Alencar Gadelha Vieira, Gabriella Cunha Vieira Ciurleo, Ludmila Belayev, Reinaldo B. Oriá

School of Medicine Faculty Publications

No abstract provided.


Association Of High Fibrinogen To Albumin Ratio With Long-Term Mortality In Patients With Spontaneous Intracerebral Hemorrhage, Shiping Chen, Yu Zhang, Yangchun Xiao, Xin Cheng, Liyuan Peng, Yixin Tian, Tiangui Li, Jialing He, Pengfei Hao, Weelic Chong, Yang Hai, Chao You, Fang Fang Jul 2024

Association Of High Fibrinogen To Albumin Ratio With Long-Term Mortality In Patients With Spontaneous Intracerebral Hemorrhage, Shiping Chen, Yu Zhang, Yangchun Xiao, Xin Cheng, Liyuan Peng, Yixin Tian, Tiangui Li, Jialing He, Pengfei Hao, Weelic Chong, Yang Hai, Chao You, Fang Fang

Department of Medical Oncology Faculty Papers

BACKGROUND: The association between fibrinogen-to-albumin ratio (FAR) and in-hospital mortality in patients with spontaneous intracerebral hemorrhage (ICH) has been established. However, the association with long-term mortality in spontaneous ICH remains unclear. This study aims to investigate the association between FAR and long-term mortality in these patients.

METHODS: Our retrospective study involved 3,538 patients who were diagnosed with ICH at West China Hospital, Sichuan University. All serum fibrinogen and serum albumin samples were collected within 24 h of admission and participants were divided into two groups according to the FAR. We conducted a Cox proportional hazard analysis to evaluate the association …


Optimizing Adherence To Antiretroviral Therapy Among Adolescents Living With Hiv In Low And Middle-Income Settings, Samuel Kizito Jul 2024

Optimizing Adherence To Antiretroviral Therapy Among Adolescents Living With Hiv In Low And Middle-Income Settings, Samuel Kizito

Brown School Graduate Student Theses and Dissertations

Globally, 1.8 million adolescents are living with HIV (ALHIV), of whom 89% (1.5 million) are in Sub-Saharan Africa (SSA) (UNAIDS, 2021b). Unfortunately, despite advances in prevention—such as the prevention of mother to child transmission (PMTCT) and pre-exposure prophylaxis—new infections continue to occur. For example, in 2021 alone, the number of new HIV infections among adolescents aged 10 to 19 was 160,000 cases. Moreover, the rate of HIV-related deaths among adolescents has only declined by 10% in the last decade, which is not fast enough to meet the 2030 global targets. Despite antiretroviral therapy (ART) playing a crucial role in controlling …


Dietary Acculturation Is Associated With Altered Gut Microbiome, Circulating Metabolites, And Cardiovascular Disease Risk In Us Hispanics And Latinos: Results From Hchs/Sol, Yi Wang, Guo-Chong Chen, Zheng Wang, Kai Luo, Yanbo Zhang, Yang Li, Amanda C Mcclain, Marta M Jankowska, Krista M Perreira, Josiemer Mattei, Carmen R Isasi, Maria M Llabre, Bharat Thyagarajan, Martha L Daviglus, Linda Van Horn, David Goldsztajn Farelo, Luis E Maldonado, Steven R Levine, Bing Yu, Eric Boerwinkle, Rob Knight, Robert D Burk, Robert C Kaplan, Qibin Qi, Brandilyn A Peters Jul 2024

Dietary Acculturation Is Associated With Altered Gut Microbiome, Circulating Metabolites, And Cardiovascular Disease Risk In Us Hispanics And Latinos: Results From Hchs/Sol, Yi Wang, Guo-Chong Chen, Zheng Wang, Kai Luo, Yanbo Zhang, Yang Li, Amanda C Mcclain, Marta M Jankowska, Krista M Perreira, Josiemer Mattei, Carmen R Isasi, Maria M Llabre, Bharat Thyagarajan, Martha L Daviglus, Linda Van Horn, David Goldsztajn Farelo, Luis E Maldonado, Steven R Levine, Bing Yu, Eric Boerwinkle, Rob Knight, Robert D Burk, Robert C Kaplan, Qibin Qi, Brandilyn A Peters

Faculty, Staff and Student Publications

Background: Dietary acculturation, or adoption of dominant culture diet by migrant groups, influences human health. We aimed to examine dietary acculturation and its relationships with cardiovascular disease (CVD), gut microbiota, and blood metabolites among US Hispanic and Latino adults.

Methods: In the HCHS/SOL (Hispanic Community Health Study/Study of Latinos), US exposure was defined by years in the United States (50 states and Washington, DC) and US nativity. A dietary acculturation pattern was derived from 14 172 participants with two 24-hour dietary recalls at baseline (2008-2011) using least absolute shrinkage and selection operator regression, with food groups as predictors of US …


Association Between Psychological Distress And Diabetic Retinopathy Among U.S. Adults, Claret Ijeoma Onukogu Jul 2024

Association Between Psychological Distress And Diabetic Retinopathy Among U.S. Adults, Claret Ijeoma Onukogu

Walden Dissertations and Doctoral Studies

Diabetes can lead to diabetic retinopathy, an eye disease that causes damaged blood vessels and the growth of abnormal ones, leading to vision loss. The two stages of the disease are non-proliferative and proliferative diabetic retinopathy. In the non-proliferative stage, diabetics develop macular edema and ischemia with shortage of blood in the macula region of the eye, and the vision eventually becomes blurry. However, the proliferative stage is the advanced stage of the disease involves neovascularization and retinal detachment. The quantitative study employed the socioecological model as the theoretical framework to examine the relationship between psychological distress and diabetic retinopathy …


Breastfeeding As Co-Occupation: Occupational Therapy’S Role In Promoting Health And Well-Being, Lisa Joelle Sutton, Julie D. Kugel, Dragana Krpalek, Arezou Salamat Jul 2024

Breastfeeding As Co-Occupation: Occupational Therapy’S Role In Promoting Health And Well-Being, Lisa Joelle Sutton, Julie D. Kugel, Dragana Krpalek, Arezou Salamat

The Open Journal of Occupational Therapy

Background: Even with efforts to encourage mothers to breastfeed exclusively for the first 6 months, the majority of women are not able to undertake breastfeeding as the sole means of infant nutrition provision for various reasons. The role of occupational therapists working with mothers who breastfeed is complex and not strongly supported in the literature. Therefore, this qualitative study was designed to examine the role that occupational therapists may engage in supporting mothers and infants in the co-occupation of breastfeeding.

Method: A qualitative phenomenological study design was applied and included 11 occupational therapists working with breastfeeding dyads. The …


Voices Of Wisdom: Geriatric Interviews On Self-Management Of Type 2 Diabetes In The United States-A Systematic Review And Metasynthesis, David F Lo, Ahmed Gawash, Kunal P Shah, Jasmine Emanuel, Brandon Goodwin, Don D Shamilov, Gaurav Kumar, Nathan Jean, Christian P White Jul 2024

Voices Of Wisdom: Geriatric Interviews On Self-Management Of Type 2 Diabetes In The United States-A Systematic Review And Metasynthesis, David F Lo, Ahmed Gawash, Kunal P Shah, Jasmine Emanuel, Brandon Goodwin, Don D Shamilov, Gaurav Kumar, Nathan Jean, Christian P White

Rowan-Virtua School of Osteopathic Medicine Departmental Research

This review is aimed at unraveling the intricacies of diabetic self-management among geriatric people, drawing on current insights and understanding the complex paths geriatric people navigate. A wide search was conducted in health-oriented databases, including CINAHL, Embase, PsycINFO, MEDLINE, PubMed, Web of Science, and Cochrane Library, while gray literature was excluded. The search combined keywords and subject headings, focusing on the geriatric population, diabetes, self-management, and qualitative research. A three-tiered screening process was employed, with titles and then abstracts initially reviewed. Full-text analysis followed, with disagreements resolved among reviewers. In total, there were 248 participants included across these eight studies. …