Digital Commons Network^™

Poor Cancer Prevention And Detection In Zimbabwe, Kenyon C. Chipman

Journal of Nonprofit Innovation

Abstract

In the aftermath of the HIV/AIDS epidemic, Sub-Saharan Africa, particularly Zimbabwe, has witnessed a surge in noncommunicable diseases such as cancer. Despite the decline in HIV/AIDS and other cancer-associated illnesses like HPV, these diseases have set the stage for a growing cancer epidemic. Key contributing factors to this rise include a lack of knowledge about cancer among both patients and health professionals, the prevalence of cancer-associated communicable diseases, and limited accessibility to early detection and prevention services and resources. These factors have led to late diagnoses, increased burden on the healthcare system, and adverse effects on individuals and families. …

Dissemination And Implementation Approach To Increasing Access To Local Pre-Exposure Prophylaxis (Prep) Resources With Black Cisgender Women: Intervention Study With Vlogs Shared On Social Media, Mandy J Hill, Laurenia Mangum, Sandra J Coker, Tristen Sutton, Diane M Santa Maria

Faculty, Staff and Student Publications

Background: Black cisgender women account for only 2% of pre-exposure prophylaxis (PrEP)-eligible people in the United States who use PrEP to prevent HIV. Owing to the low PrEP use, Black cisgender women continue to contract HIV more frequently than women from every other racial group. Intervention efforts that can bridge the link between knowing that PrEP prevents HIV and support with access to PrEP are necessary for Black cisgender women.

Objective: The purposes of the vlogs through the campaign were to share information about ways to prevent HIV using PrEP and fact-based education and provide access to PrEP resources with …

Navigating The Low Covid-19 Vaccination Rate Nexus: Biblical Interpretations & Practices Of Pentecostal Christians In Dmv, Patricia Mbah Nchamukong

Walden Dissertations and Doctoral Studies

The development and release of a vaccine during an epidemic is aimed at mitigating the adverse effects of infection, transmission, and spread of the disease. However, this does not always guarantee the acceptance of the vaccine by the entire population, as was the case with the COVID-19 vaccine. The low COVID-19 vaccine rate within the Black Pentecostal Christian community in Washington, D.C., Maryland, and Virginia (DMV) is a public health concern. Some factors that might have influenced the decision of this population to accept or reject the vaccine have been linked to politics, anti-COVID-19 vaccine sentiments, and religion. The purpose …

The Present And Future Of Ai: Ethical Issues And Research Opportunities, Ankita Srivastava, Marco Marabelli, Danielle Blanch-Hartigan, Jeffrey Moriarty, Evan Carey

Computer Information Systems Faculty Publications

Healthcare is currently a fast-changing industry with AI and generative AI (GenAI) playing a prominent role in the transformation of clinical as well as managerial practices. Clinical practices involve AI to diagnose diseases and develop new drugs and compounds, while managerial practices concern AI-supporting processes such as billing patients and insurance companies, handling electronic medical records, and supporting remote connections with patients, increasingly using virtual and augmented reality. Yet, all these opportunities offered by AI come with challenges involving potential ethical issues, such as discrimination, bias, lack of accessibility, and privacy issues. In March 2024, we organized a panel with …

Cost-Effectiveness Of Intrapartum Azithromycin To Prevent Maternal Infection, Sepsis, Or Death In Low-Income And Middle-Income Countries: A Modelling Analysis Of Data From A Randomised, Multicentre, Placebo-Controlled Trial, Jackie K. Patterson, Simon Neuwahl, Sydney Kirsch, Janet L. Moore, Alan T.N. Tita, Waldemar A. Carlo, Adrien Lokangaka, Antoinette Tshefu, Musaku Mwenechanya, Elwyn Chomba, Avinash Kavi, Mrityunjay C. Metgud, Shivaprasad S. Goudar, Richard J. Derman, Poonam Shivkumar, Manju Waikar, Archana Patel, Patricia L. Hibberd, Paul Nyongesa, Fabian Esamai, Osa A. Ekhaguere, Sherri Bucher, Saleem Jessani, Shiyam S. Tikmani, Sarah Saleem, Blair J. Wylie, Robert L. Goldenberg, Sk Masum Billah, Ruth Lennox, Rashidul Haque, William A. Petri, Manolo Mazariegos, Nancy F. Krebs, Jennifer J. Hemingway-Foday, Denise Babineau, Marion Koso-Thomas, Elizabeth M. Mcclure, Melissa Bauserman

Global Health Articles

BACKGROUND: Sepsis is one of the leading causes of maternal mortality globally. In 2023, the Azithromycin Prevention in Labor Use (A-PLUS) trial showed intrapartum azithromycin for women planning a vaginal birth reduced the risk of maternal sepsis or death and infection. We aimed to evaluate the cost-effectiveness of intrapartum azithromycin for pregnant people planning a vaginal birth in low-income and middle-income countries (LMICs) using A-PLUS trial data.

METHODS: We compared the benefits and costs of intrapartum azithromycin versus standard care across 100 000 model simulations using data from the A-PLUS trial and a probabilistic decision tree model that included 24 …

A Preliminary Study On The Role Of Personal History Of Infectious And Parasitic Diseases On Self-Reported Health Across Countries, Gerit Pfuhl, Filipe Prazeres, Marta Kowal, Toivo Aavik, Beatriz Abad-Villaverde, Reza Afhami, Leonardo Aguilar, Grace Akello, Laith Al-Shawaf, Jan Antfolk, Chiemezie S. Atama, Derya Atamtürk Duyar, Roberto Baiocco, Sercan Balım, Carlota Batres, Yakhlef Belkacem, Théo Besson, Adam Bode, Merve Boğa, Jordane Boudesseul, Mahmoud Boussena, Hamdaoui Brahim, Nana Burduli, Ali R. Can, Hakan Cetinkaya, Antonio Chirumbolo, Dimitri Chubinidze, Clément Cornec, Bojana M. Dinić, Seda Dural, Izzet Duyar, Samuel O. Ebimgbo, Edgardo Etchezahar, Peter Fedor, Tomasz Frackowiak, David A. Frederick, Katarzyna Galasinska, Felipe A. García, Talia Gomez Yepes, Dmitry Grigoryev, Farida Guemaz, Ivana Hromatko, Gözde Ikizer, Steve M.J. Janssen, Julia A. Kamburidis, Tina Kavčič, Nicolas Kervyn, Farah Khan, Aleksander Kobylarek, Mehmet Koyuncu, Yoshihiko Kunisato, David Lacko, Miguel Landa-Blanco, Linda H. Lidborg, Samuel Lins, Tetyana Mandzyk, Silvia Mari, Tiago Marot, Martha Martinez-Banfi, Alan D. A. Mattiassi, Marlon Mayorga-Lascano, Moises Mebarak, Norbert Meskó, Maria Rosa Miccoli, Vita Mikuličiūtė, Taciano L. Milfont, Katarina Mišetić, Mara Morelli, Jean C. Natividade, Izuchukwu L. G. Ndukaihe, Felipe C. Novaes, Salma S. Omar, Mohd Sofian Omar Fauzee, Tobias Otterbring, Barış Özener, Simon Ozer, Ju Hee Park, Irena Pavela Banai, Farid Pazhoohi, Mariia Perun, Martin Pírko, Ekaterine Pirtskhalava, Katarzyna Pisanski, Nejc Plohl, Koen Ponnet, Pavol Prokop, Matheus F. F. Ribeiro, Frederico Rosário, Ayşegül Şahin, Fatima Zahra Sahli, Dušana Šakan, Oksana Senyk, Henrik Siepelmeyer, Diana Ribeiro Da Silva, Sangeeta Singh, Çağlar Solak, Sinem Söylemez, Anna Studzinska, Chee-Seng Tan, Gulmira Topanova, Merve Topcu Bulut, Ezgi Toplu-Demirtaş, Bastien Trémolière, Singha Tulyakul, Joaquín Ungaretti, Jaroslava V. Valentova, Marco A.C. Varella, Mona Vintila, Tatiana Volkodav, Anna Wlodarczyk, Yao-Yuan Yeh, Gyesook Yoo, Oulmann Zerhouni, Marcos Zumárraga‑Espinosa, Maja Zupančič, Piotr Sorokowski

Psychology Faculty Articles and Research

Objectives

Infectious diseases are often associated with decline in quality of life. The aim of this study is to analyze the relationship between personal history of communicable, i.e., infectious and parasitic diseases and self-rated health.

Study design

Secondary analysis of a large dataset multi-country observational study.

Methods

We used a four-pronged analysis approach to investigate whether personal history of infectious and parasitic diseases is related to self-reported health, measured with a single item.

Results

Three of the four analyses found a small positive effect on self-reported health among those reporting a history of pathogen exposure. The meta-analysis found no support …

H.B. 22-1326: Analysis Of Colorado’S Fentanyl Policy, William Morris

Undergraduate Theses, Capstones, and Recitals

Fentanyl is one the most potent drugs on the market, its synthetic nature makes it is one of the deadliest at the lowest quantities. Many of its injectors are entirely unaware of its existence when they consume cocaine, methamphetamine, Xanax, ecstasy, and heroin. Nationwide and within Colorado, the use of synthetic fentanyl has perpetuated a crisis that threatens the health and safety of numerous communities, with both fatal and non-fatal overdoses continually on the rise. In 2022, Colorado passed H.B. 22-1326, aimed at curbing fentanyl deaths and non-fatal overdoses, by further criminalizing fentanyl possession. Understanding the effectiveness of felony-heavy drug …

The Impact Of Covid-19 On The United States Higher Education System, Phoenix Daniel Van Wormer

University Honors Theses

In the spring of 2020, colleges across the United States rapidly transitioned to online/remote learning during the COVID-19 global pandemic. Since then, online and remote learning have evolved into an integral component of higher education. This thesis examines the extent to which COVID-19-mandated remote and online learning impacted students pursuing higher education in the United States. By utilizing research that compares academic structures before and after the pandemic, I demonstrate how the shift to online and remote learning has changed teaching and learning methods. I also evaluate the impact of these changes on student performance and engagement, with particular focus …

The Importance Of Recruitment Of Low-Income Pregnant Persons In Interdisciplinary Research To Understand The Impact Of Social And Environmental Determinants: Lessons Learned About Implementation And Recruitment, Erika R. Marquez, Amanda Haboush-Deloye, Elizabeth M. Lawrence, Selam Ayele, Courtney Coughenour, Nora Doyle, Wynona Dizon, Lizbeth Perez Rodriguez, Chloe Bombara

Environmental & Global Health Faculty Research

Background: Prior research indicates that enrolling underrepresented populations in clinical research is challenging. Although research has identified some barriers to participation and strategies to overcome them, studies have made little progress in being inclusive and representative. There remains a great need for including racial/ethnic minorities, low-income families, and pregnant women in research. The purpose of this article is to describe the implementation of enrollment strategies used in our study to understand the feasibility of building a maternal cohort and better understand the relationship between environmental and social impacts on maternal exposure and child outcomes.

Methods: Working across multiple academic units, …

Antimicrobial Performance Of A Novel Drug-Eluting Bioenvelope, Zerelda Esquer Garrigos, Sunil Kapur, Michelle Leroux Williams, M Rizwan Sohail

Faculty, Staff and Students Publications

No abstract provided.

Grounded In Touch: The Science Behind Anxiety Relief And Human Connection, Misty Rhoads Ph.D. Czb, Mary Murphy M.A., Lmt, Czb, Mary L. Behrens Pt, Czb, Rhonda Salvo Pt, Czb, Sarah-Elizabeth Anderson Lmt, Czb, Clare Gowen Pt, Czb, Dawn Humbles Lsh, Czb, Veronica Quarry Pt, Czb, Deborah Rosene Ph.D., Czb, Wendy Tribelhorn Lmt, Czb, Jared Urcheck L.Ac, Czb, Deanna Waggy Otr, Czb

Journal of Transformative Touch

Background: Anxiety disorders are among the most pervasive mental health challenges worldwide, affecting individuals across all demographics and socioeconomic backgrounds. As a leading contributor to disability and diminished quality of life, anxiety continues to rise in prevalence, exacerbated by global crises and societal stressors. This study explored how Zero Balancing (ZB) supports individuals with anxiety. Researchers hypothesized that ZB would lower the perceived severity of general anxiety and reduce perceived anxiety symptoms.

Methods: A concurrent mixed-methods phenomenological research design was utilized to honor the holistic nature of bodywork and explore participants' lived experiences. This national study involved 320 ZB sessions …

Improving Dietary Supplement Information Retrieval: Development Of A Retrieval-Augmented Generation System With Large Language Models, Yu Hou, Jeffrey R Bishop, Hongfang Liu, Rui Zhang

Faculty, Staff and Student Publications

Background: Dietary supplements (DSs) are widely used to improve health and nutrition, but challenges related to misinformation, safety, and efficacy persist due to less stringent regulations compared with pharmaceuticals. Accurate and reliable DS information is critical for both consumers and health care providers to make informed decisions.

Objective: This study aimed to enhance DS-related question answering by integrating an advanced retrieval-augmented generation (RAG) system with the integrated Dietary Supplement Knowledgebase 2.0 (iDISK2.0), a dietary supplement knowledge base, to improve accuracy and reliability.

Methods: We developed iDISK2.0 by integrating updated data from authoritative sources, including the Natural Medicines Comprehensive Database, the …

A Brief Commentary On Human-Ai Attachment And Possible Impacts On Family Dynamics, Brandon T. Mcdaniel Phd, Amanda Coupe, Allison Weston, Jessica A. Pater

Health Services and Informatics Research

Objective: In this brief commentary article, we outline an emerging idea that it may be possible that as Conversational Artificial Intelligence (CAI) becomes a part of an individual’s environment and interacts with them their attachment system may become activated, potentially leading to behaviors—such as seeking out the CAI to feel safe in times of stress—that have typically been reserved for human-to-human attachment relationships. We term this attachmentlike behavior, but future work must determine if these behaviors are driven by a Human-AI attachment or something else entirely. Background: CAI is an emerging technical advancement that is the cornerstone of many everyday …

A Narrative Review Of The Covid-19 Infodemic And Censorship In Healthcare, Mitchell Liester, Sohaib Ashraf, Patricia Callisperis, Hector Carvallo, Shankara Chetty, Robert Enzenauer, Carlos Franco-Paredes, Raul Pineda, Panagis Polykretis, Rachel Wilkenson, Peter Mccullough

Secrecy and Society

Ideological and financial motivations have undermined science for decades. In this narrative review, we explore how organizations and governments used misinformation, disinformation, censorship, and secrecy to manage the COVID-19 pandemic. Various rationales for employing censorship and secrecy during the COVID-19 pandemic are examined including how organizations and governments create confusion about the risks associated with their products and blame avoidance to shift responsibility and to avoid accountability for their actions. Methods of censorship employed during the COVID-19 pandemic are reviewed, examples are provided, and the consequences of these actions are reviewed. Information included in this review was obtained from scientific …

Emerging Clostridioides Difficile Ribotypes Have Divergent Metabolic Phenotypes, Firas S Midani, Heather A Danhof, Nathanael Mathew, Colleen K Ardis, Kevin W Garey, Jennifer K Spinler, Robert A Britton

Faculty, Staff and Students Publications

Clostridioides difficile is a gram-positive spore-forming pathogen that commonly causes diarrheal infections in the developed world. Although C. difficile is a genetically diverse species, certain ribotypes are overrepresented in human infections, and it is unclear if metabolic adaptations are essential for the emergence of these epidemic ribotypes. To identify ribotype-specific metabolic differences, we therefore tested carbon substrate utilization by 88 C. difficile isolates and looked for differences in growth between 22 ribotypes. As expected, C. difficile was capable of growing on a variety of carbon substrates. Further, C. difficile strains clustered by phylogenetic relationship and displayed ribotype-specific and clade-specific …

An Exploration Of The Experiences Of Perinatal Depression And Anxiety Among Pregnant And Parenting Adolescents In The Tampa Bay Area Of Florida, Olajumoke Adetoun Ojeleye

USF Tampa Graduate Theses and Dissertations

Perinatal depression (PND) and perinatal anxiety (PNA) are increasing among pregnant and parenting adolescents (PPAs), with PNA often underrecognized. This leads to significant socioeconomic costs and adverse maternal consequences if untreated. Hence, this dissertation explores the experiences of PND and PNA among PPAs, focusing on their knowledge gaps, perception, mental health needs, care preferences, and access to PMH care. The research employs a qualitative design (free-listing and in-depth interviews) to gather participant insights. Key findings reveal that many PPAs possess limited knowledge about PNA when compared to PND. Lack of support from partners, family, and peers emerged as the topmost …

Gender Differences In Weight Perceptions And Intentions Among Hispanic Youth In The United States, Kristy Gregurek

Walden Dissertations and Doctoral Studies

Childhood obesity is a global epidemic and a serious issue for children and adolescents in the United States. Despite recognition of its dangers, obesity remains a public health concern, with both genetic and environmental factors contributing to its prevalence. Of particular concern is the higher obesity rates among Hispanic children, who face disproportionately significant psychological and physical health risks. Using the theory of planned behavior, this study aimed to investigate the lack of knowledge regarding gender differences in weight perceptions and intentions, the relationship between physical activity and weight perception, and the role each may play in obesity among Hispanic …

Exploring Profiles Of Fathers Integrating Food And Physical Activity Parenting Practices, John A Jimenez-Garcia, Louise C Mâsse, Robert L Newton, Salma M Musaad, Alicia Beltran, Teresia M O'Connor

Children’s Nutrition Research Center Staff Publications

Objective: This study aims to identify fathers' profiles integrating food parenting practices (FPP) and physical activity parenting practices (PAPP).

Design: We analysed cross-sectional data. The fathers completed the reduced FPP and PAPP item banks and socio-demographic and family dynamics (co-parenting and household responsibility) questionnaires. We identified fathers' profiles via latent profile analysis. We explored the influence of social determinants, child characteristics and family dynamics on fathers' profiles using multinomial logistic regression.

Setting: Online survey in the USA.

Participants: Fathers of 5-11-year-old children.

Results: We analysed data from 606 fathers (age = 38 ± 8·0; Hispanic = 37·5 %). Most fathers …

Mobilizing Prevention And Early Detection Of Alzheimer's Disease And Related Dementias (Adrd) In Allegheny County Through The Area Agency On Aging (Aaa), Laiba N. Mirza

Public Health Capstone Projects

1. Objectives: In collaboration with the Department of Human Services (DHS): the Area Agency on Aging (AAA) using the Healthy Brain Initiative (HBI), my capstone project will involve the development of a comprehensive literature review examining the impacts of Alzheimer’s disease and related dementias (ADRD) on patients and their caregivers. The project aims to help the AAA focus on strategies to delay the onset of ADRD in Allegheny County. It also seeks to evaluate and enhance early detection programs for ADRD established by the AAA in communities within the county. Additionally, the project will explore how public health initiatives can …

Aiding Counseling Services To Increase Cultural Knowledge About Black And Lgbtq+ Populations, Brianna L. Walden

Public Health Capstone Projects

OBJECTIVES: The capstone project I would like to undertake is the creation of a quality improvement plan for the counseling and social work department of The Children’s Home to help them expand to reach vulnerable populations. A quality improvement plan, along with graphics reflecting the current data about mental health, will be delivered to The Children’s Home which they will be able to use in future projects and grant applications.

METHODS: The methods and research will be based on the 2024 Community Health Needs Assessment (CHNA) and Community Counseling Needs Assessment conducted by The Children’s Home in August 2024 to …

Cortical Visual Impairment Awareness And Education, Sarah Kozosey

Public Health Capstone Projects

Objectives: This Capstone Project, conducted in collaboration with The Children’s Home (TCH), aims to raise awareness of the educational aspect of cortical visual impairment (CVI) by compiling the work already done in schools, hospitals, and the communities it serves. The focus is on raising awareness and education, interdisciplinary collaboration, diagnosis and early detection, public health implications, and strategic planning and implementation through secondary research. Methods: This project uses CH’s strategic plan to improve the flow of grand rounds already enforced. Meetings with multiple people on the Marketing & Development team and Pediatric VIEW team will answer how much progress has …

Fighting Instinct: The Brain, Emotions And Decision-Making In The Water, Jill Nash, Sam Hills

International Journal of Aquatic Research and Education

This conceptual paper explores the complex interplay among the human brain, emotions, and decision-making processes, particularly in aquatic environments. Integrating insights from neuroscience, psychology, and behavioural economics, we investigate how instinctual responses and emotional states influence our decisions during water-related activities. By analysing both biological and psychological factors, the paper aims to illuminate the intricacies of human behaviour in various aquatic settings and highlights significant gaps in the research on emotional decision-making that warrant further investigation. Additionally, the paper suggests interventions, including plausible communication strategies, to mitigate the impact of instinctual responses and improve safety and decision-making efficiency.

The Perceived Benefits Of And Barriers To Open-Water Swimming: A Mixed-Methods Examination, David Elliott Ph.D, Mark A. Christie Ph.D

International Journal of Aquatic Research and Education

This study set out to determine the perceived benefits of, and barriers to, open-water swimming (OWS). Adopting a mixed-methods approach, six hundred and sixty-five open-water swimmers responded to an online survey consisting of the Exercise Benefits and Barriers Scale (EBBS) and a series of open-ended questions. Data from the EBBS revealed the strongest perceived benefits to be ‘Psychological Outlook’ and ‘Life Enhancement.’ In terms of barriers, those presented in the EBBS received low ratings with only ‘Physical Exertion’ considered as being somewhat problematic. Content analysis performed on the open-ended responses showed social aspects, mental well-being, and connection to nature as …

A Preventionist Framework For Reducing Drowning: A Case For Parenting Interventions, Miriam G. Clark, Linda Quan, Patricia Chamberlain

International Journal of Aquatic Research and Education

Drowning is preventable but still claims the lives of over 300,000 people worldwide every year. The purpose of this theoretical review paper is threefold: 1) discuss the theoretical framework for a multi-faceted system of prevention; 2) discuss the importance of parenting, a crucial area where current drowning prevention research is falling short in this multi-faceted approach; and 3) discuss how evidence-based practices from psychosocial parenting research could be used to create drowning prevention interventions that support parents to implement water safety practices in their families. Practical ideas for integrating psychosocial parent interventions with drowning prevention knowledge are discussed. Such interventions …

From Pregnancy To Beyond: Renewed Emphasis On Comprehensive Hiv Prevention In South Africa., Chibuzor M. Babalola, Remco P.H. Peters, Christina A. Muzny, Dvora Joseph Davey, Christopher M. Taylor, Mandisa M. Mdingi, Freedom Mukomana, Lindsey De Vos, Andrew Medina-Marino, Jeffrey D. Klausner

School of Medicine Faculty Publications

No abstract provided.

Precision Phenotyping For Curating Research Cohorts Of Patients With Unexplained Post-Acute Sequelae Of Covid-19, Alaleh Azhir, Jonas Hügel, Jiazi Tian, Jingya Cheng, Ingrid V Bassett, Douglas S Bell, Elmer V Bernstam, Maha R Farhat, Darren W Henderson, Emily S Lau, Michele Morris, Yevgeniy R Semenov, Virginia A Triant, Shyam Visweswaran, Zachary H Strasser, Jeffrey G Klann, Shawn N Murphy, Hossein Estiri

Faculty, Staff and Student Publications

BACKGROUND: Scalable identification of patients with post-acute sequelae of COVID-19 (PASC) is challenging due to a lack of reproducible precision phenotyping algorithms, which has led to suboptimal accuracy, demographic biases, and underestimation of the PASC.

METHODS: In a retrospective case-control study, we developed a precision phenotyping algorithm for identifying cohorts of patients with PASC. We used longitudinal electronic health records data from over 295,000 patients from 14 hospitals and 20 community health centers in Massachusetts. The algorithm employs an attention mechanism to simultaneously exclude sequelae that prior conditions can explain and include infection-associated chronic conditions. We performed independent chart reviews …

Developing A Novel Index For Individual-Level Social Determinants And Cardiovascular Diseases In The Coronary Artery Risk Development In Young Adults (Cardia) Study, Tao Gao, Yinan Zheng, Brian Joyce, Lei Liu, Lili Liu, Catarina Kiefe, Sarah Forrester, Bing Yu, Ankeet Bhatt, Penny Gordon-Larsen, Donald Lloyd-Jones, Kai Zhang, Lifang Hou

Faculty, Staff and Student Publications

Background: Social determinants of health (SDH) have been found to contribute to cardiovascular risk and the development of cardiovascular disease (CVD). However, few studies have examined early-life exposure to SDH and the combined effect of multiple SDH measures on CVD. There is an urgent need to develop an SDH index for use in practice and clinical settings.

Methods: A total of 3189 participants from the CARDIA Study who had chest CT scans at the year-25 (Y25) visit were included in this study. Personal and parental SDH measures, including education, occupation, income, financial strain, and childhood family environment, were obtained through …

Functional Characterization Of Cryopreserved Plasmodium Yoelii Sporozoites In Vitro, Victoria I. Mills

USF Tampa Graduate Theses and Dissertations

Malaria is a major global health burden, contributing to morbidity and mortality across various continents. Due to challenges in malaria research and its advancements, developing novel interventions and further understanding host-parasite interactions is required for future studies. Plasmodium vivax is a human malaria species that is difficult to maintain in laboratory settings, posing obstacles in research. Cryopreservation offers a reliable method to provide a consistent supply of sporozoites for reproducible studies. Plasmodium yoelii is a rodent malaria model commonly used in studies due to its genetic similarity to human malaria species. Utilizing cryopreserved P. yoelii sporozoites potentially extends their usability …

Access To Outreach Athletic Trainers Improves Orthopedic Specialty Appointment Adherence, Katie Sniffen, Katie Smith, Michael Rozier, Katherine Stamatakis, Paula Buchanan, Leslie Hinyard

Journal of Sports Medicine and Allied Health Sciences: Official Journal of the Ohio Athletic Trainers Association

Background: Adolescent sports participation carries an inherent risk of musculoskeletal injury, with an estimated 2 million injuries occurring annually among high school athletes. Navigating the healthcare system to receive appropriate care can be challenging, potentially leading to delayed treatment and poorer outcomes. Athletic trainers (ATs) may play a crucial role in facilitating timely access to specialized care. The objective of this study was to assess the relationship between referral pathways (outreach athletic trainers (OATs), non-outreach athletic trainers (ATs), urgent care (UC), and emergency department (ED)) and appointment adherence while controlling for predisposing, enabling, and need factors. Methods: Using electronic medical …

Control Of Clostridioides Difficile Virulence And Physiology By The Flagellin Homeostasis Checkpoint Flic-Fliw-Csra In The Absence Of Motility, Duolong Zhu, Katherine J Wozniak, Firas Midani, Shaohui Wang, Xingmin Sun, Robert A Britton

Faculty, Staff and Students Publications

Mutations affecting Clostridioides difficile flagellin (FliC) have been shown to be hypervirulent in animal models and display increased toxin production and alterations in central metabolism. The regulation of flagellin levels in bacteria is governed by a tripartite regulatory network involving fliC, fliW, and csrA, which creates a feedback system to regulate flagella production. Through genomic analysis of C. difficile clade 5 strains (non-motile), we identified they have jettisoned many of the genes required for flagellum biosynthesis yet retain the major flagellin gene fliC and regulatory gene fliW. We therefore investigated the roles of fliC, fliW …