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A New Full Orifice Disc Valve For Mitral Replacement, Rodman E. Taber, Yasuharu Imai

Henry Ford Hospital Medical Journal

Because of dissatisfaction with certain features of the currently available ball and disc valve prostheses when implanted in patients with mitral stenosis and a small volume left ventricle, a full orifice discoid valve has been designed which avoids many of these shortcomings. The valve has been tested mechanically in a pulse duplicator and compared lo existing prostheses. High speed cine studies were used to evaluate turbulence. Implantation was carried out in animals. Evaluation by these various methods indicates that the valve is satisfactory for human implantation and may have significant advantages over other artificial valves when used in patients with …

Chronic Acute Hepatitis, Klaus Anselm

Henry Ford Hospital Medical Journal

The current literature concerning chronic acute hepatitis is reviewed. The clinical picture, morphology, laboratory data and etiology are discussed. It is pointed out that much work is still to be done toward fully understanding this disease. A program of treatment is suggested.

Decompressive Laminectomy In The Management Of Spinal Epidural Metastases, J. Speed Rogers, Robert S. Knighton

Henry Ford Hospital Medical Journal

In a series of 60 patients undergoing decompression laminectomy for metastatic malignancy, the median survival was 3.3 months with 11 patients (18%) living for at least one year and ambulating during part of this survival period. Forty-three per cent of the group were able to ambulate for at least some period postoperatively. If a patient could ambulate preoperatively he had a two-thirds chance of ambulating afterwards; conversely, if he could not ambulate preoperatively. he had a two-thirds chance of not ambulating postoperatively. The lymphoma group had the best prognosis. Long lesions and highly vascular tumors fared poorly. Paralysis (as defined …

Eosinophils, Lawrence C. Sweet

Henry Ford Hospital Medical Journal

Despite the fact that the eosinophilic leukocyte has been known as a distinct entity for 123 years and has been the subject of extensive research and numerous scientific papers, its precise function remains an enigma. A diverse array of clinical conditions are known to be associated with eosinophilia but even here the role of this cell in the pathological process remains unknown. Recent experimenlal work suggests that allergens, antigens, antigen-antibody complexes, and components of complement may function as eosinophilotactic stimuli. Eosinophils phagocytize antigen-antibody complexes as well as a variety of particulate substances. Their granules have been identified as lysosomes and …

Scrotal Inflation: A New Cause For Subcutaneous, Mediastinal And Retroperitoneal Emphysema, George Bush, Robert K. Nixon

Henry Ford Hospital Medical Journal

No abstract provided.

Back Matter

Henry Ford Hospital Medical Journal

No abstract provided.

The Chemistry Of Pesticides, Walter R. Benson

United States Food and Drug Administration: Publications

Introduction

This review is limited to the structures and a few reactions of the pesticides mainly insecticides-that affect mammalian systems and that are the subject of papers by other authors in this monograph. There is no attempt to give a complete review of the chemistry of pesticides. It is intended only to show the breadth and depth of pesticide chemistry through the use of examples. With proper use of the references, and of the papers by Crosby, Freed and Montgomery, and Owens in this monograph, the reader will be able to find information for other chemicals.

Nomenclature

Pesticides or economic …

Front Matter

Henry Ford Hospital Medical Journal

No abstract provided.

The Clinical Use Of Fluorine18 In Bone Scanning, R. A. Gatesi, A. T. Vulpetti, T. L. Kosnik, W. G. Tucker, R. W. Talley

Henry Ford Hospital Medical Journal

Roentgenograms are frequently inadequate in the detection of early osseous metastases. Isotope bone scan is a more sensitive diagnostic procedure. Reported here are findings on 40 patients with known or suspected osseous involvement using the short-lived radionuclide 18F. Comparison with standard roentgenograms and clinical follow-up demonstrated 11 early detections. 18F was found to be a very suitable agent for isotope bone scanning. Ilustrative cases are presented

Primary Closure And Iliac Osteotomy In The Treatment Of Exstrophy Of The Bladder: A Case Report, Louis Z. Shifrin, Arthur Johnson, Lester Weiss

Henry Ford Hospital Medical Journal

Exstrophy of the bladder is a rare but serious congenital affliction. Untreated, exstrophy is associated with unacceptable morbidity and mortality. A case report is presented in which primary closure of the bladder and bilateral iliac osteotomy was successfully employed to gain anatomic correction of the bladder defect. However, the value of this surgical technique in restoring normal function of the lower urinary tract system is questionable.

Studies Of The Electrical Parameters And Behavioral Effects Of An Eeg ''Seizure Discharge", W. R. Mccrum, R. M. Lee, H. Van Den Ende, L. D. Proctor, J. A. Lee

Henry Ford Hospital Medical Journal

Nemastrina monkeys with multiple electrodes implanted in the amygdaloid area of the brain were used to study the relationship of electrical seizures and overt behavior. The electrical seizures were produced by long duration electrical pulses administered through the implanted electrodes. There appears to be no relationship between this kind of electrical seizure and lever pressing performance. Relationships between depth EEG, depth impedance, DC potential and surface EEG are observed and as a consequence some ideas concerning the genesis of the electroencephalogram are put forth.

A Preliminary Evaluation Of Azathioprine (Imuran®) In The Treatment Of Multiple Sclerosis, William G. Tucker, K. H. Kapphahn

Henry Ford Hospital Medical Journal

A theoretical approach to the unknown etiology of multiple sclerosis is presented in this preliminary study which reports the results of empiric treatment with azathioprine. Imuran® therapy produced stabilization of the disease, neurological improvement, and no progress of neurological dysfunction or loss of any regained function. Evidence points toward a viral-induced immunological defect. Abnormal gamma globulins found in the cerebral spinal fluid suggest an immunological etiology.

Sarcoidosis And Idiopathic Thrombocytopenic Purpura: First Report Of Coexistence, Ellis J. Vanslyck, Dipankarsri Dasgupta

Henry Ford Hospital Medical Journal

A patient is described in whom sarcoidosis of the mediastinal lymph nodes was found during the course of acute idiopathic thrombocytopenic purpura. The association of these two diseases should be differentiated from the more commonly seen thrombocytopenia of hypersplenic origin, occurring during the disseminated stage of sarcoidosis, in which granulomatous involvement of an enlarged spleen is found. An elevated serum IgM immunoglobulin level was present. These observations possibly strengthen the concept that an immunological disorder plays a significant role in sarcoidosis.

Etiology Of Congenital Heart Disease, Jami G. Shakibi

Henry Ford Hospital Medical Journal

The different factors involved in the etiology of congenital heart disease are discussed with particular attention lo the teratogenic agents. Experimental production of congenital heart disease in animals is reviewed. This seems to be a very promising field for investigations, which may eventually lead to an understanding of the etiology of congenital heart disease and its prevention.

Isotope Cisternography — Risa®, J. L. Fenton, W. R. Eyler, L. A. Dusault, G. M. Griser, F. C. Stebner

Henry Ford Hospital Medical Journal

Several cases are presented which illustrate the indications and results of a relatively new procedure of intrathecal injection of radioiodinated human seruin albumin I 131 to demonstrate cerebrospinal fluid dynamics. This procedure has been used in conjunction with pneumoencephalography in the diagnosis of communicating hydrocephalus. A proper dose as well as adequate volume are necessary to obtain diagnostic scans.

The Vasopressor Effect Of Indigo Carmine, C. C. Wu, Arthur J. Johnson

Henry Ford Hospital Medical Journal

Indigo carmine only recently was found to have a vasopressor effect. Intravenous injection in anesthetized and unanesthetized patients resulted in blood pressure elevation and bradycardia. This effect appears analogous to that of serotonin which indigo carmine structurally resembles. This drug should be used with caution in patients with cardiovascular disease.

Nodular Excision Of Prostatic Carcinoma: Experience With Four Patients, E. E. Steinhardt, A. W. Bohne

Henry Ford Hospital Medical Journal

No abstract provided.

Publications Of The Staff Of The Henry Ford Hospital And The Edsel B. Ford Institute For Medical Research

Henry Ford Hospital Medical Journal

No abstract provided.

Commencement Program 1969, Loma Linda University

Commencement Programs

CONTENTS

4 | The Vesper Service (La Sierra Campus)

6 | The Vesper Service (Loma Linda Campus)

8 | The Sermon (La Sierra Campus)

10 | The Sermon (Loma Linda Campus)

12 | Conferring of Degrees

15 | Candidates for Degrees

30 | Awards

33 | Academic Costume

Study To Save Block Island, Designer's News, May 19,1969, Students Of Risd, Risd Archives

Ecology and Environment

RISD Landscape Architecture Study to Save Block Island Article from Designer's News, May 19, 1969 student newspaper.

Hormonal Regulation Of Lipolysis And Phosphorylase Activity In Human Fat Cells, Jay Moskowitz, John N. Fain

Faculty Publications

A B S TR A C T Prostaglandin E₁ (PGE₁) at a concentration of 1 ng/ml antagonized theophylline, and norepinephrine induced release of glycerol and free fatty acids (FFA) in human fat cell preparations. Insulin at higher doses also inhibited theophylline-stimulated lipolysis. The N₆-2-O^'dibutyryl derivative of cyclic adenosine monophosphate (DCAMP) stimulated lipolysis. Prostaglandin E1 did not significantly inhibit the lipid mobilizing effects of DCAMP. Changes in glycogen phosphorylase activity after treatment with theophylline, norepinephrine, DCAMP, and PGE₁ paralleled those of lipolysis. These results suggest that in man as in experimental animals lipolysis …

Slipped Capital Femoral Epiphysis (Follow-Up Study), C. Leslie Mitchell

Henry Ford Hospital Medical Journal

Epiphyseolysis, or slipping of the capital femoral epiphysis, remains a controversial problem from the standpoint of etiology and treatment. This report is limited to results of treatment of severely slipped epiphyses at the Henry Ford Hospital from 1937 lo 1967. The surgical technique and postoperative care are described. Of a total of 137 hips treated surgically in this period, 38 were severe, requiring transcervical osteotomy and internal fixation. The follow-up results of these 38 cases are reported.

Derotation Osteotomy Of The Femur In Cerebral Palsy, James R. Glessner Jr.

Henry Ford Hospital Medical Journal

Generally satisfactory experience is reported in a 10-year study and evaluation of a modified surgical technique for correction of anteversion and associated gait abnormalities in cerebral palsy. The 25 patients so treated represent only 2% of those seen during the period.

Osteochondroma Of The Vertebra, C. H. Hickey

Henry Ford Hospital Medical Journal

A seldom considered manifestation of multiple hereditary exostosis — vertebral lesions with and without neurological complications — is discussed. Three additional cases are added to the sparse literature on the subject with hope that the spinal ostetochondroma will be searched for and treated before neurological complications become manifest.

Pulmonary Angiograms And Isotope Lung Scans — Their Role In The Diagnosis Of Pulmonary Embolism, Robert S. Ormond, Ellet H. Drake, Richard A. Rideout, Sudarsan Misra

Henry Ford Hospital Medical Journal

Experience gained in the study of 307 patients by pulmonary angiograms and/or isotope lung scans has led to concepts regarding the limitation and usefulness of each. The scan is ideally useful when the patient with suspected pulmonary embolism has a negative chest film. Angiograms should be performed when there are parenchymal infiltrations on the chest radiograph or when a definite diagnosis is necessary. Either study should be performed early in the course of the patient's illness to permit diagnostic study.

Pacemaker Induced Ventricular Tachycardia: Report Of A Case With The "Runaway Pacemaker", Remigio Garcia, Eduardo Arciniegas

Henry Ford Hospital Medical Journal

The "runaway pacemaker" is a serious pacing failure resulting from battery exhaustion or malfunction of some of the pulse generator components. Hypotension, rapid rate, dyspnea and palpitations were the main clinical features of one example of this iatrogenic arrhythmia presented here. When diagnosed, this condition must be treated as an emergency by disconnecting the subcutaneous wire electrodes from the unit and attaching them to a new pulse generator. The importance of frequent examinations with electrocardiographic recordings for the early recognition of this complication is emphasized.

A Hazard Of "Diet Pop", Charles Wolf

Henry Ford Hospital Medical Journal

Calorie-free carbonated beverages, or "diet pops," are becoming increasingly popular and many households no longer contain the older, more familiar, sugar containing, carbonated beverages. Because physicians frequently make use of "soda pop" when prescribing treatment for common pediatric conditions such as febrile episodes or bouts of vomiting or diarrhea, the following case report is presented to illustrate the fact that physicians must ascertain that the beverage to be used to maintain hydration is not calorie free.

Front Matter

Henry Ford Hospital Medical Journal

No abstract provided.

Bovine Testicular Antihyaluronidase In Rabbits: Production And Purification, Gerald Fine, Sheikh M. Saeed, Gerald A. Logrippo

Henry Ford Hospital Medical Journal

An antibody chemically and immunologically active against bovine testicular hyaluronidase was produced in rabbits by injecting them with purified hyaluronidase in complete Freund's adjuvant. Nonspecific antibodies, reacting with human and bovine proteins which had little or no hyaluronidase activity, were also detected by the double agar immunodiffusion technique using antiserum against these proteins. After absorption of the antiserum with bovine heart and liver and removal of the precipitation bands against human and bovine tissue proteins, the antiserum inhibited the chemical activity of the purified hyaluronidase and exhibited immunologic activity against the purified hyaluronidase as shown by the agar double immunodiffusion …

Pathology Of Secretory Otitis: A Temporal Bone Report, Luis F. Perez De Moura, Royal C. Hayden Jr.

Henry Ford Hospital Medical Journal

During the past 10 years, the collection and microscopic examination of human temporal bones has provided the opportunity to correlate clinical symptomatology and findings with histopathology. The case findings in this report support the clinical suspicion of glandular mucosal disease in some forms of secretory otitis media.