Digital Commons Network^™

Viral Kinetics Of Sequential Sars-Cov-2 Infections, Stephen M. Kissler, James A. Hay, Joseph R. Fauver, Christina Mack, Caroline G. Tai, Deverick J. Anderson, David D. Ho, Nathan D. Grubaugh, Yonatan H. Grad

Journal Articles: Epidemiology

The impact of a prior SARS-CoV-2 infection on the progression of subsequent infections has been unclear. Using a convenience sample of 94,812 longitudinal RT-qPCR measurements from anterior nares and oropharyngeal swabs, we identified 71 individuals with two well-sampled SARS-CoV-2 infections between March 11^th, 2020, and July 28^th, 2022. We compared the SARS-CoV-2 viral kinetics of first vs. second infections in this group, adjusting for viral variant, vaccination status, and age. Relative to first infections, second infections usually featured a faster clearance time. Furthermore, a person's relative (rank-order) viral clearance time, compared to others infected with the …

Engaging The Aging Process: Unlock The Fountain Of Youth, Abeni El-Amin Ph.D.

Management Faculty Publications

Employment for aging is a significant aspect shaping the aging processes during formative years. Therefore, work opportunities combined and consequential impacts later in life merit special consideration. Given that population aging has become a global pattern with ensuing changes in labor markets far and wide, there is increased concern about the impacts of retirement around the globe and the macroeconomic advantages frequently connected with delaying retirement. It is fundamental for nations with aging populations to maintain profitability, given an aging workforce. Governments must make it simpler for individuals to maintain a significant presence in the workforce. This contribution focuses on …

High Medicaid Nursing Homes: What Nursing Home And Resident Characteristics Are Associated With Covid 19 Cases?, Abigail A. Cobbina

Honors Undergraduate Theses

The coronavirus pandemic exposed the systemic issues faced by nursing homes with a higher percentage of Medicaid residents. By using the Brown University's Long-Term Care focus facility-level data and the Centers for Medicare and Medicaid Services data, the study examines the association between the nursing home and resident characteristics with Covid-19 cases in high-Medicaid nursing homes. Fifty-eight facilities in Florida were identified as having residents whose primary support was Medicaid. The findings from the study suggest a higher proportion of Medicaid residents, for-profit status, and chain affiliation status, were associated with a higher prevalence of Covid-19 cases among nursing home …

A Systematic Literature Review Of Research From 2010 To 2020 Addressing User-Generated Online Comments Related To Health Issues And Recommendations For Future Research, Muhammad Ittefaq, Mauryne Abwao, Ioana A. Coman, Waqas Ejaz

School of Communication Studies - Faculty Scholarship

This systematic literature review was conducted to provide insights into how online readers’ comments have been studied in the context of health over a 10-year span. About 593 studies published between 2010 and 2020; of these, 34 met the research criteria for inclusion. Our findings reveal that 60% of the studies focused on the United States, and a qualitative method was used in 74.3% of these studies. About 23.5% of the studies explored vaccine-related issues. Our results reveal that among the selected studies, 76.5% and 20.6% had female and male first authors, respectively. Textual analysis of abstracts shows that the …

Does An Educational Intervention Program On Infection Precautions Decrease Absentee Rates In Schools?, Shelby Florann Keltner, Madelyn Salonga

Nursing | Senior Theses

During our community health clinical rotation in a public school, we observed abundant absences in the kindergarten class, which led us to inquire: What is the possible cause for the multiple absences? Further, we noticed that the students had a hand hygiene knowledge deficit. These observations led us to hypothesize that due to direct contact transmission many absences were related to infection-related illnesses, and without proper technique and understanding of hand washing, infectious diseases will continue to have a high probability of transmission in schools. The objective of our investigation is to identify the prevalence of this issue in communities …

Cancer Immunotherapy: A Breakthrough In Patient Care, Abdou-Samad Kone, Nour El Imane Issam Salah, Amina Ghouzlani, Abdallah Badou

Health Sciences

Cancer is one of the world's leading causes of death. Conventional therapies, such as surgical resection, radiotherapy, and chemotherapy, have improved patient management and have shown overwhelming progress. However, the incidence and mortality rates among cancer patients are still extremely high, at approximately 20,5 % and 10,6 % for both sexes, respectively. This may be due to the heterogeneity of tumors, their special microenvironment, and the development of resistance to certain conventional therapies. The concept of immunotherapy provided a new perspective on patient treatment. The interaction of tumor cells with their microenvironment depends on different factors and conditions that promote …

Institute Of Public Health Newsletter- Volume 7, Issue 3, Institute Of Public Health (Iph)

Institute of Public Health Newsletter (IPHNL) and Other Publications

No abstract provided.

Contraception And Healthcare Utilization By Reproductive-Age Women Who Use Drugs In Rural Communities: A Cross-Sectional Survey., Ximena A. Levander, Canyon A. Foot, Sara L. Magnusson, Ryan R. Cook, Jerel M. Ezell, Judith Feinberg, Vivian F. Go, Kathryn E. Lancaster, Elizabeth Salisbury-Afshar, Gordon S. Smith, Ryan P. Westergaard, April M. Young, Judith I. Tsui, P. Todd Korthuis

Epidemiology and Environmental Health Faculty Publications

BACKGROUND: Women who use drugs (WWUD) have low rates of contraceptive use and high rates of unintended pregnancy. Drug use is common among women in rural U.S. communities, with limited data on how they utilize reproductive, substance use disorder (SUD), and healthcare services.

OBJECTIVE: We determined contraceptive use prevalence among WWUD in rural communities then compared estimates to women from similar rural areas. We investigated characteristics of those using contraceptives, and associations between contraceptive use and SUD treatment, healthcare utilization, and substance use.

DESIGN: Rural Opioids Initiative (ROI) - cross-sectional survey using respondent-driven sampling (RDS) involving eight rural U.S. regions …

Field Days Against Flu Days: Decreasing Missed School Days In The D.C. Metropolitan Area Due To Influenza, Elyana Belete, Evan Bowie, Maria - Carmen Miko, Raymond Weeden

DC Health and Academic Prep Program (DC HAPP)

The World Health Organization (WHO) estimates that about 290,000 to 650,000 people worldwide are affected annually by the flu (WHO, 2023). Children ages 0–17 are more prone to contracting the flu due to increased contact with other individuals in daycare and grade school as they are more likely to put their hands in their mouths and less likely to practice proper hygiene. Additionally, they have less developed immune systems to fight off infections (CDC, 2020). This leads to an increased likelihood of catching an illness that can spread from person to person compared to adults. According to the Morbidity and …

Sisyphean Frustrations: The Impetus For Improving Harm Reduction Strategies In Minneapolis, Mn, Jordan Baker

Theses and Graduate Projects

Background: The last decade has seen an alarming rise in deaths attributed to opioid use. Considering the ever-increasing mortality rate contributable to opiate use disorder, it is important to identify and utilize more efficacious public health interventions.

Purpose: The focus of this paper is identifying the current harm reduction strategies being implemented in Minneapolis MN, the history of harm reduction in the US, and opportunities to improve existing systems to better engage current conditions.

Methods: The primary research method for this community assessment was volunteer work with Southside Harm Reduction in Minneapolis, MN. Through community clean-ups the researcher was able …

Saftey Of Covid-19 Vaccines In Real World Studies, Khawla Amar Mohamed Gammudi

CGU Theses & Dissertations

Background: The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been present since its outbreak in 2019. Despite global efforts to fully halt its spread, new strains are emerging daily. Various efforts have been undertaken to slow down the infection's spread by implementing different restrictive measures and policies, such as lockdowns, social distancing, and mask-wearing. However, the most effective approach to controlling this disease is through vaccinations (Chen, 2021). Substantial efforts have been dedicated to encouraging people in the United States to receive COVID-19 vaccines and booster doses. As of December 7, 2022, approximately 68.5% of the world's …

Recent Advances In Research And Management Of Human Monkeypox Virus: An Emerging Global Health Threat, Parveen Kumar, Benu Chaudhary, Nishant Yadav, Sushma Devi, Ashutosh Pareek, Sujatha Alla, Fnu Kajal, Behdin Nowrouzi-Kia, Vijay Kumar Chattu, Madan Mohan Gupta

Engineering Management & Systems Engineering Faculty Publications

In 2003, the United States saw an epidemic of monkeypox that was later traced back to rodents of West Africa infected with the monkeypox virus (MPXV). Disease in the United States seemed less severe than the smallpox-like disease in the Democratic Republic of the Congo (DRC). In this study, researchers analyzed data from Central Africa: two distinct MPXV clades were confirmed by sequencing the genomes of MPXV isolates from Western Africa, the United States, and Central Africa. By comparing open reading frames across MPXV clades, scientists can infer which virus proteins might account for the observed variation in pathogenicity in …

Adaptive Evaluation For Systems In Rapid Change Or Sustained Transition: Innovations And Applications Generated From A Community-Based Diabetes Prevention Program During The Covid-19 Pandemic, Amy Kuhn

CGU Theses & Dissertations

Program evaluation is a key part of the life cycle of public health and prevention science projects. But in complex environments or evolving situations, existing evaluation theory faces challenges in successful practical application. Process evaluation can track changes as a program runs, but when a program operates outside of its original design, questions can arise related to fidelity of implementation and interpretation of results. Outcome evaluation often requires a closed system without changes to determine actual effects of a program, but in times of complicated change that isolation can be difficult to achieve or to work around. In practice, systems …

Proposing An Rna Interference (Rnai)-Based Treatment For Human Immunodeficiency Virus (Hiv) By Analyzing The Post-Transcriptional Gene Targeting Of Sars-Cov-2, Hepatitis C Virus, And A549 Lung Cancer Cells, Arjun Jagdeesh

UROP Posters

Human Immunodeficiency Virus (HIV) is a retrovirus that infects CD4+ T cell lymphocytes in humans, leading to the development of Acquired Immunodeficiency Syndrome (AIDS) if left untreated. While current treatment methods, including antiretroviral combination treatments, effectively limit HIV replication, HIV can evade these treatments due to its high mutation rate. Long-term antiretroviral treatment can also be toxic to patients, meaning patients would benefit from a new mechanism of HIV treatment. RNA interference (RNAi) is an antiviral pathway found in mammals, plants, and insects that involves a small-interfering RNA that is incorporated into a protein complex called the RNA-induced Silencing Complex …

Clonal Diversity, Antibiotic Resistance, And Virulence Factor Prevalence Of Community Associated Staphylococcus Aureus In Southeastern Virginia, Katelyn D. Cranmer, Mohan D. Pant, Suzanne Quesnel, Julia A. Sharp

EVMS School of Health Professions Faculty Publications

Staphylococcus aureus is a significant human pathogen with a formidable propensity for antibiotic resistance. Worldwide, it is the leading cause of skin and soft tissue infections (SSTI), septic arthritis, osteomyelitis, and infective endocarditis originating from both community- and healthcare associated settings. Although often grouped by methicillin resistance, both methicillin-resistant (MRSA) and methicillin-sensitive (MSSA) strains are known to cause significant pathologies and injuries. Virulence factors and growing resistance to antibiotics play major roles in the pathogenicity of community-associated strains. In our study, we examined the genetic variability and acquired antibiograms of 122 S. aureus clinical isolates from SSTI, blood, and urinary …

Massachusetts Prevalence Of Opioid Use Disorder Estimation Revisited: Comparing A Bayesian Approach To Standard Capture-Recapture Methods, Jianing Wang, Nathan Doogan, Katherine L. Thompson, Dana Bernson, Daniel Feaster, Jennifer Villani, Redonna Chandler, Laura F. White, David Kline, Joshua A. Barocas

Statistics Faculty Publications

Background: The National Survey on Drug Use and Health (NSDUH) estimated the prevalence of opioid use disorder (OUD) among the civilian, noninstitutionalized people aged 12 years or older in Massachusetts as 1.2% between 2015 and 2017. Accurate estimation of the prevalence of OUD is critical to the success of treatment and resource planning. Various indirect estimation approaches have been used but are subject to data availability and infrastructure-related issues.

Methods: We used 2015 data from the Massachusetts Public Health Data Warehouse (PHD) to compare the results of two approaches to estimating OUD prevalence in the Massachusetts population. First, we used …

Influence Of Stigma On Retention In Hiv Care And Adherence To Antiretroviral Therapy In Specialized Hiv Clinics Targeting Men Who Have Sex With Men And Transgender Women In Lima, Peru, David Oliveros Oliveros

Public Health Theses

HIV stigma is a social determinant of health that can influence adherence to antiretroviraltherapy (ART) and engagement in HIV care that impacts viral suppression levels for people with HIV (PWH). In Peru, a country which lags behind 95-95-95 targets for HIV outcomes, LGBTQ-affirming clinics have the potential to mitigate these negative health effects of stigma and discrimination among men who have sex with men (MSM) and transgender women (TGW), two populations that continue to be disproportionately affected by HIV. Using a validated HIV stigma scale and multivariate logistic regression models, this study assessed the magnitude and types of stigma present …

Intersectoral Responses To Climate Change And Waterborne Diseases In The Caribbean Region: Current Actions And Pathways Forward Using The One Health Framework, Sydney A. Steel

Public Health Theses

The Caribbean exists on the frontlines of climate change, and many climate-related threats are already felt throughout the region and projected to worsen in the coming decades. A critical climate-related threat is that of waterborne diseases, as extreme weather events, sea level rise, and temperature increases are shown to contribute to potable water inaccessibility and a more favorable environment for pathogen proliferation and transmission. The complexity of this challenge calls for increased regional and inter-sectoral collaboration in both preparedness and response efforts. Countries and territories across the Caribbean are currently displaying variable yet marked interest in One Health, yet there …

Case Series; Imaging In Lesser-Known Ailments Of The Pituitary Gland And Sellar Region, Harisha H L, Kavya Bhadrapura Thimmegowda, Ajay Hanumanthu, Vikram Patil Dr, Gurumurthy B, Dr Abhijith Roys

Digital Journal of Clinical Medicine

No abstract provided.

The Impact Covid-19 On The Healthcare Industry’S Systems And Policies: A Case Study, Jameyshia Franklin

West Chester University Doctoral Projects

People worldwide experienced some impacts from the 2019 Coronavirus at various degree. The healthcare industry worldwide was significantly affected by the high volume of patients being infected with the Coronavirus. The COVID-19 virus brought on several challenges for the healthcare industry and the federal government in the United States. Hospitals operated under severe circumstances to treat sick COVID-19 patients and keep their employees safe from contracting the disease. Government mandated social distancing, mask wearing, and cancelation and closing of services to assist with stopping the spread of the virus. This study aimed to identify how the pandemic affected the healthcare …

Institute Of Public Health Newsletter- Volume4, Issue2, Institute Of Public Health (Iph)

Institute of Public Health Newsletter (IPHNL) and Other Publications

No abstract provided.

Institute Of Public Health Newsletter- Volume5, Issue1, Institute Of Public Health (Iph)

Institute of Public Health Newsletter (IPHNL) and Other Publications

No abstract provided.

Nonsystematic Reporting Biases Of The Sars-Cov-2 Variant Mu Could Impact Our Understanding Of The Epidemiological Dynamics Of Emerging Variants, Mary E. Petrone, Carolina Lucas, Bridget Menasche, Mallery I. Breban, Inci Yildirim, Melissa Campbell, Saad B. Omer, Edward C. Holmes, Albert I. Ko, Nathan D. Grubaugh, Akiko Iwasaki, Craig B. Wilen, Chantal B. F. Vogels, Joseph R. Fauver

Journal Articles: Epidemiology

Developing a timely and effective response to emerging SARS-CoV-2 variants of concern (VOCs) is of paramount public health importance. Global health surveillance does not rely on genomic data alone to identify concerning variants when they emerge. Instead, methods that utilize genomic data to estimate the epidemiological dynamics of emerging lineages have the potential to serve as an early warning system. However, these methods assume that genomic data are uniformly reported across circulating lineages. In this study, we analyze differences in reporting delays among SARS-CoV-2 VOCs as a plausible explanation for the timing of the global response to the former VOC …

Covid-19 Vaccine Hesitancy In Asean: Insights From A Multi-Wave Survey Database From July 2020 To March 2021, Kenneth Y. Hartigan-Go, Ronald U. Mendoza, Madeline Mae A. Ong, Jurel K. Yap

Ateneo School of Medicine and Public Health Publications

Objectives

Early studies on COVID-19 vaccine hesitancy showed varied intensity across countries, which was linked to various factors such as socio-economic conditions, information sources, and issues of trust in government, scientific experts, and the health sector. This study aims to evaluate the determinants of vaccine hesitancy to offer insights into the strategies that may be successful in designing communications campaigns for enhanced vaccination uptake.

Methods

Through logistic regression, this study examines correlates of survey data from five Southeast Asian countries, namely Indonesia (ID), Malaysia (MY), Philippines (PH), Thailand (TH), Vietnam (VN) collected by the Massachusetts Institute of Technology Initiative on …

An Epidemiological Synthesis Of Emerging And Re-Emerging Zoonotic Disease Threats In Cameroon, 2000-2022: A Systematic Review, Nancy B. Tahmo, Frankline Sevidzem Wirsiy, Dum-Buo Nnamdi, Marcel Tongo, James V. Lawler, M. Jana Broadhurst, Charles S. Wondji, David Brett-Major

Journal Articles: Epidemiology

INTRODUCTION: Population factors such as urbanization, socio-economic, and environmental factors are driving forces for emerging/re-emerging zoonotic diseases in Cameroon. To inform preparedness and prioritization efforts, this study mapped out epidemiological data (including prevalence) of zoonotic diseases occurring in Cameroon between 2000 and 2022 by demographic factors.

METHODS: Following the PRISMA guidelines, a protocol was registered in the PROSPERO database (CRD42022333059). Independent reviewers searched the PubMed, Embase, CINAHL, Cochrane, and Scopus databases on May 30, 2022 for relevant articles; duplicates were removed, and the titles, abstracts, and full texts were screened to identify eligible articles.

RESULTS: Out of 4142 articles identified, …

Dynamic Patterns And Modelling Of Covid-19 Early Transmission By Dynamic Mode Decomposition, Dehong Fang, Lei Guo, M. Courtney Hughes, Jifu Tan

Faculty Articles, Papers, and Other Scholarship

Introduction

Understanding the transmission patterns and dynamics of COVID-19 is critical to effective monitoring, intervention, and control for future pandemics. The aim of this study was to investigate the spatial and temporal characteristics of COVID-19 transmission during the early stage of the outbreak in the US, with the goal of informing future responses to similar outbreaks.

Methods

We used dynamic mode decomposition (DMD) and national data on COVID-19 cases (April 6, 2020–October 9, 2020) to model the spread of COVID-19 in the US as a dynamic system. DMD can decompose the complex evolution of disease cases into linear combinations of …

Does Environmental Testing Of C. Difficile Predict Whether A Patient Is Positive With C. Difficile?, David Caccese

Public Health Theses

Clostridioides difficile is a major public health threat and frequent cause of healthcare-associated infections. Hospitals have struggled to control C. difficile due in part to the challenge of identifying asymptomatic C. difficile carriers and because of C. difficile’s ability to survive on environmental surfaces for long periods. Asymptomatic carriers and environmental surfaces can contribute to C. difficile transmission. Screening of all patients for C. difficile upon hospital admission is not feasible and asymptomatic patients may not be accepting of surveillance testing. Thus, this study examines whether sampling the patient’s room environment once they have been admitted can indicate a patient …

Sleep Aid Use During Early Pregnancy And The Risk Of Birth Defects, Meredith M. Howley

Legacy Theses & Dissertations (2009 - 2024)

This dissertation examines the validity of maternal self-reported medication exposures and then explores the associations between self-reported sleep aid use, including zolpidem specifically, and birth defects using data from three population-based case-control studies conducted within the United States. The first aim of this dissertation was to explore agreement between two sources of prescription medication use in early pregnancy: medical records and self-reported interview data from the Birth Defects Study To Evaluate Pregnancy exposureS (BD-STEPS). We observed that agreement of prescription data between self-report and medical records varies by whether the medication is used chronically or episodically. While self-reported medication information …

Maternal Exposure Of Perfluoroalkyl Substances (Pfas) During Pregnancy And Wheeze In Children : The Upstate Kids Study, Faria Sharmin

Legacy Theses & Dissertations (2009 - 2024)

Background: Prenatal exposure to perfluoroalkyl substances (PFASs), a group of persistent environmental chemicals with endocrine disrupting abilities, has been associated with immunomodulation and may contribute to the etiology of asthma in young children. The need for research and additional prospective analysis clearly exists to measure the impact of the chemicals (PFAS) on child wheeze or asthma. We used newborn dried blood spots to quantify two PFAS and their associations with infant wheeze in the Upstate KIDS population.Methods: We measured, perfluoro octane - sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) in 2071 singleton and 1040 twin infants born to mothers in …

Examining The Association Between Childhood Adversity And Later Life Cardiometabolic Diseases, Shreya Shrinivas

Legacy Theses & Dissertations (2009 - 2024)

ACEs stands for Adverse Childhood Experiences, which are traumatic or stressful events that occur in childhood before the age of 18 (Wisner, 2022). These experiences can include physical, emotional, or sexual abuse; neglect; household dysfunction, such as parental separation, domestic violence, substance abuse, or incarceration; or exposure to community violence, racism, or discrimination. Research has shown that individuals who experience ACEs are at a higher risk for developing chronic diseases such as heart disease, diabetes, cancer, and mental health disorders later in life (Felitti, 2002). This is because ACEs can cause toxic stress, which is chronic activation of the stress …