Evaluating Impacts Of The Trichloroethylene Metabolite S-(1,2-Dichlorovyinyl)-L-Cysteine On Transcriptomic Responses And Cytokine Release In A Macrophage Model: Implications For Pregnancy Outcomes, Annella Benjamin, Erica Boldenow, Sammy Jaber, Kelly M. Bakulski, John Dou, Justin Colacino, Peter Mancuso, Sean Harris

University Faculty Publications and Creative Works

Trichloroethylene (TCE) is a volatile synthetic chemical used in various industrial processes like metal degreasing. Large amounts of TCE have been released into the environment. Exposure to TCE can occur through routes, such as inhalation for workers using TCE or ingestion of drinking water in contaminated areas. Macrophages are key immune cells in virtually all tissues in the human body, including the fetal membranes, making them a plausible target for DCVC-induced immunotoxicity. Macrophages are critical for maintaining anti-microbial defenses during pregnancy, but little data exists on TCE immunotoxicity during pregnancy. We previously showed that the TCE metabolite, S-(1,2-dichlorovinyl)-L-cysteine (DCVC), …

Association Between Neighborhood-Level Social Vulnerability And Hypertension Outcomes, John E. Brush Jr., Chungsoo Kim, Yuntian Liu, Xin Xin, Chenxi Huang, Iris J. Lundy, Jordan R. Asher, Mitsuaki Sawano, Patrick Young, Jacob Mcpadden, Mark Anderson, John S. Burrows, Harlan M. Krumholz, Yuan Lu

Department of Medicine Faculty Publications

Background

Neighborhood-level social vulnerability is associated with hypertension prevalence and severity and with cardiovascular complications in conditions other than hypertension, but its association with cardiovascular complications in patients with hypertension is understudied.

Objectives

The aim of the study was to examine how the neighborhood-level social vulnerability index (SVI) influences cardiovascular outcomes in a large, diverse cohort of patients with hypertension.

Methods

We used electronic health data to examine the association between census tract-level rankings for the SVI with a composite endpoint of incident myocardial infarction, congestive heart failure, or stroke.

Results

In a longitudinal cohort of 330,972 patients with hypertension …

Quantifying The Public Health Impact Of Lyme Disease In Minnesota: A Simulation Analysis Of Reported And Unreported Cases, Kathleen Angell, M. Jana Broadhurst, Jianghu James Dong, Tzeyu L. Michaud, Abraham Degarege, Roberto Cortinas, David Brett-Major

Journal Articles: Epidemiology

Background: Lyme disease, the most common vector-borne disease in Minnesota, is estimated to be underreported by a factor of 10. Delayed diagnosis and misdiagnosis may lead to health complications and increased personal and societal costs. Environmental factors can help to predict high disease years, allowing for early intervention to decrease disease burden. Objective: To estimate the health and cost burdens of Lyme disease and the extent to which they could be diminished by public health intervention when high-incidence Lyme disease years are forecasted. Methods: We used 5 two-dimensional Monte Carlo simulations to estimate (1) average annual expected burden of Lyme …

Principles Of Biomedical Research, Faina Linkov, Matthew C. Kostek

Open Education Materials

HLT 430/530

CC BY-NC-SA

Vaccines And Publics: A Variety Of Engagement Experiences, David H. Lee

Publications and Research

This chapter is about some of the sites and scenes where members of the public are exposed to (and engage in) vaccination discourse. To preview, after a brief introduction, we begin with messaging models of communication, followed by the move from messaging to engagement. Next, case examples of public engagement with vaccines are introduced, from pandemic influenza preparedness in the U.S., to polio eradication initiatives in India, and then to COVID-19 public engagement events in England. Settings of public engagement are noted, including online, in churches and museums. Then, there’s a section about communication and public participation, seen as either …

The Role Of Climate Change In The Pandemic Agreement Negotiations, Cristina Arnes Sanz

Public Health Theses

Introduction: For over three years, Member States of the World Health Organization (WHO) have been negotiating a treaty to prevent, prepare for, and respond to future pandemics. The Pandemic Agreement is anticipated to be adopted at the World Health Assembly in May 2025. Growing scientific evidence underscores the effects of climate change on infectious diseases, including those that could lead to pandemics. This thesis examines how climate change has been addressed in the drafting and negotiations of the Pandemic Agreement.

Methods: All the references related to climate change in the transcripts of the publicly broadcast Intergovernmental Negotiating Body (INB) meetings …

Resilience And Reality: Exploring The Lived Experiences Of People Living With Hiv In Texas During The Covid-19 Pandemic – A Qualitative Study., Ahmed F. Alanazi

Social Work Dissertations - Archive

This study investigated the lived experiences of individuals living with HIV (PLWH) in the Dallas-Fort Worth (DFW) area of Texas during the COVID-19 pandemic, using an Interpretative Phenomenological Analysis (IPA) framework. The research examined the intersection of health, social dynamics, and psychological resilience among PLWH, who faced compounded vulnerabilities due to systemic inequities and the dual public health crises of HIV and COVID-19. Through semi-structured interviews with ten participants from diverse backgrounds, the study captured the profound impacts of disrupted healthcare systems, heightened stigma, and social isolation on this marginalized population. The findings reveal that the pandemic exacerbated existing inequities …

Estimating Per-Infection Cost And Burden For Dengue And Zika As A Function Of Antibody-Dependent Enhancement, Christopher M. Kribs

Mathematics Faculty Publications - Archive

The complex immune interactions produced by the tetravalent dengue vaccine Dengvaxia have foregrounded the important role of antibody-dependent enhancement (ADE) in dengue infection. Some evidence exists that ADE may extend beyond the four dengue serotypes to Zika, a closely related flavivirus transmitted by the same mosquito species as dengue, and may also account for the increased severity of some cases. Estimates of the public health impact of dengue vaccination may then need to include its effects on the transmission of Zika in addition to dengue. This study gathers primary references to build estimates of per-case economic cost and disease burden …

The Intersection Of Indigenous Medicine And Biomedicine In Santiago, Chile, Sam Boehm

Hispanic Studies Honors Papers

No abstract provided.

Prepared To Protect: Improving Cardiac Emergency Response Through Education And Action Planning In Youth Club Sports, Melissa Garcia

Nursing | Senior Theses

Sudden cardiac arrest (SCA) is the leading cause of death in youth sports, illuminating the essential demand for adequate emergency response, including cardiopulmonary resuscitation (CPR), automated external defibrillator (AED) usage, and comprehensive emergency action plans (EAPs). Research shows that despite the importance of prompt intervention, the majority of youth club sports programs outside of the school setting lack the training and resources needed to respond effectively to SCA incidents. This study will evaluate the effectiveness of an educational seminar that includes CPR/AED training and EAP simulation exercises in improving participants’ knowledge, skills, and confidence in managing cardiac emergencies. A quasi-experimental …

Mistrust Among Injured Immigrant Workers: A Conceptual Framework, Maude Arsenault, Daniel Côté, Jessica Dubé

Revues de littérature, synthèses de connaissances

Background

In Quebec, injured workers have access to medical assistance, wage replacement indemnities, and rehabilitation measures, with most injuries resolved easily. However, a small percentage of cases require a lengthy rehabilitation process, which is particularly complex when involving immigrants. The therapeutic alliance is at the heart of the process, involving mutual trust and confidence and a degree of consensus about the therapeutic interventions to be used and, ultimately, the return to work.

Objective

This article delves into the concept of mistrust as more than the absence of trust, and sheds light on its role in the rehabilitation process of immigrant …

The Intersection Of Broadband And Health: Exploring Rural-Urban Disparities In Colorado, Hunter Anderson, Kristen Paradine

Scholarship in Medicine - All Papers

Modern healthcare infrastructure and progression depend on robust and reliable broadband access. Many areas of the U.S., however, still face limited access which exacerbates access to care and healthcare inequities. These trends can be observed in rural counties across the country, where resource constraints and reduced access to infrastructure remain limited. The correlation however between different health outcomes and broadband access in Colorado has not been widely explored in literature.
This study examines the relationship between broadband availability and different healthcare outcomes for rural and urban counties of Colorado by utilizing data from the County Health Rankings and Roadmaps for …

Knowledge, Perception And Acceptability Of Human Papillomavirus Vaccine Among Moroccan Medical Students, Safa Ibork, Asmaa Naim, Mohamed Khalis, Soumaya Rafii, Abire Allaoui

Health Sciences

Background:

Cervical cancer is the second most common cancer among women and the third leading cause of cancer-related mortality in Morocco. In October 2022, the Ministry of Health introduced the human papillomavirus (HPV) vaccine into the national immunization program. This study aimed to assess knowledge, satisfaction, and acceptability regarding HPV infection and vaccination among Moroccan medical students.

Methods:

A cross-sectional study was conducted between September 2021 and July 2022 among fifth-year and higher medical students from all nine Moroccan medical universities. Data were collected through an online questionnaire and analyzed descriptively and analytically.

Results: A total of 636 students participated …

Evaluating Ai-Generated Essays For Bias In Public Health Topics, Spring Cooper

Open Educational Resources

This is a sample assignment: Students will use AI tools to generate essays on public health topics, critically evaluate these essays for potential biases, and understand the ethical implications of using AI-generated content in public health.

Revolutionising Indoor Air Quality To Stop Pandemics With Germicidal Ultraviolet (Guv) Technology, P. Jacob Bueno De Mesquita

Arts & Sciences Faculty Publications

This exclusive interview with Assistant Professor of Public Health and leader of TheHuman Health and Harmony Lab (H3) Jacob Bueno de Mesquita explores the hiddendangers of shared air, the transformative potential of Germicidal Ultraviolet (GUV)technology, and the vision for a future where indoor spaces contribute to healthier, moreresilient communities.

Enablers And Barriers To The Use Of Portable Ultrasound Devices For Antenatal Care In Rural Health Centers In The Philippines, Jacob Anthony Batuhan, Reynan Hernandez, Florentina Villanueva, Airen Sigue, Kevyn Yu, Kate Wad-Asen, Beatriz Carandang, Jeremie Bartelheimer

Ateneo School of Medicine and Public Health Publications

Objectives

This qualitative study aims to examine the enablers and barriers to portable ultrasound device utilization for antenatal care in rural Philippine health centers, with the goal of improving maternal outcomes and reducing maternal mortality.

Methods

We conducted focus group discussions with 18 healthcare workers (midwives, a nurse, and a radiologic technician) and 20 pregnant women across 5 rural health centers. We used inductive thematic analysis to identify system-related, provider-related, and client-related enablers and barriers.

Results

Enablers included free ultrasound services, hospital policies requiring prenatal scans, provider training, awareness creation, patient interest and acceptance, and confidence in HCWs’ capabilities. Barriers …

Spontaneous Pneumothorax In Adolescents: Is Video-Assisted Thoracoscopy Mandatory?, Soufiane Essamoud, Mohamed Lahlou, Anne Olland, Francois Lefebvre, Anne Lehn, Isabelle Chevalier, Raphael Moog, Pierre-Emmanuelle Falcoz, Isabelle Talon, Hicham Zerhouni

Health Sciences

Background: Treatment of spontaneous pneumothorax involves conservative treatment or surgery. Our goal was to evaluate the need for surgical approach using Video- Assisted Thoracoscopic Surgery (VATS) for patients presenting spontaneous pneumothorax. Methods: Patients aged between 14 and 20 years old treated for spontaneous pneumothorax were included into an observational retrospective study. Patients were divided into two groups: Those with a success of conservative treatment at the initial presentation (Group A), and those where VATS was performed at initial presentation after failure of conservative treatment (Group B). Results: 134 patients were included with a median of 6.5 years follow-up. 102 (76,1%) …

Undergraduate Nursing Students' Perceptions Of A Screen-Based Virtual Simulation And Self-Debriefing: A Qualitative Study., Fatima Zahra Mahou, Guillaume Decormeille, Asmae Khattabi

Health Sciences

The integration of virtual simulation and self-debriefing in nursing education offers promising approaches for enhancing students' competency in medication administration and dosage calculation. This study aims to explore undergraduate nursing students' perceptions and experiences with virtual simulation and self-debriefing, building on findings from a previously published RCT that demonstrated improved learning outcomes through these approaches. In the first phase (self-debriefing), 153 students answered five open-ended questions, followed by a focus group with six students in the second phase.The data were analyzed using qualitative content analysis by two independent coders to ensure consistency and credibility. The study highlights the benefits of …

An Analysis Of Mental Health And Workplace Absenteeism, Kristin Marie Vrona

Graduate Research Theses & Dissertations

This dissertation examines the effect of mental health on own health-related absenteeism among employed adults in the United States, using data from the 2010–2014 Medical Expenditure Panel Survey (MEPS). The MEPS uniquely differentiates between absences due to one’s own health and those due to another person’s health, enabling causal estimation of individual-level factors influencing absence decisions.

The analysis incorporates both mental and physical health measures, including diagnostic indicators and self-reported general well being, which are used as proxies for severity that may affect both diagnosed and undiagnosed individuals. Results reveal a consistent pattern: individuals experiencing high psychological distress but lacking …

Understanding The Pathogenesis Of Uveitis In Ebola Virus Disease Survivors: An Observational Cohort And Cross-Sectional Study Protocol For Clinical, Molecular Virologic And Immunologic Characterisation, Caleb D. Hartley, Susanne Linderman, Tolulope Fashina, Laura Ward, Carolyn Drews-Botsch, Catherine Pratt, Sanjana Kuthyar, Alcides Filho Fernandes, Ye Huang, Charlene Choo, Nam Nguyen, Jessica Carag, Jill Morgan, Colleen S. Kraft, Angela L. Hewlett, David Brett-Major, John S. Schieffelin, Robert F. Garry, Donald Grant, Grant A. Justin, Christopher D. Conrady, Justine R. Smith, Brent R. Hayek, Shiama Balendra, Nisha Acharya, Thuy Doan, Anais Legand, Pierre Formenty, Xiankun Zeng, Ibrahim Conteh, Matthew Jusu Vandy, Lloyd Harrison-Williams, Jalikatu Mustapha, Zikan Koroma, Michael R. Wiley, Ian Crozier, Jean-Claude Mwanza, Jessica G. Shantha, Rafi Ahmed, Steven Yeh, Smile And Evict-Vr Investigator Study Groups

Journal Articles: Epidemiology

INTRODUCTION: The 2013-2016 Western African outbreak of the Ebola virus disease (EVD), the largest recorded outbreak since the discovery of Ebola virus (EBOV) in 1976, destabilised local health systems and left thousands of survivors at risk for postacute sequelae, including vision-threatening uveitis. In an EVD survivor with severe panuveitis, the detection of persistent EBOV in the aqueous humour, long after clearance of acute viremia, focused clinical and research attention on the host-EBOV interaction in the unique terrain of ocular immune privilege. Despite the recognition that uveitis is common and consequential in EVD survivors, our understanding of pathogenesis is extremely limited, …

Academic Proficiency In Ugandan Children With Sickle Cell Anemia: A Cross-Sectional Study, Robert Opoka, Shubaya Kasule Naggayi, Paul Bangirana, Simple Ouma, Betty Nyangoma, Annet Birabwa, Grace Nambatya, Maxencia Kabatabaazi, Ann Jacqueline Nakitende, Dennis Kalibbala

Paediatrics and Child Health, East Africa

Introduction: Academic proficiency is crucial for advancing learning goals, school advancement, and future economic security. Children with sickle cell anemia (SCA) in sub-Saharan Africa (SSA) may be at risk of disease-associated learning difficulties. Limited data exist on this topic among school-age children in the region. We aimed to assess academic proficiency in a sample of children with SCA in Uganda compared with unaffected controls.

Methods: This cross-sectional study was conducted in Kampala, Uganda. Participants were school-going children with SCA, aged 6–12 years, attending Mulago Hospital SCA Clinic, and age-matched sibling controls without SCA. Academic proficiency was assessed by the Wide …

Addressing Housing As A Health-Related Social Need: Insights From A Medicaid Housing Pilot In Oregon, Megan Holtorf, Benjamin Gronowski

Articles, Abstracts, and Reports

No abstract provided.

Exploring The Impact Of Pain Management Agreements On Physician-Patient Relationship: A Qualitative Analysis From The Patient’S Perspective In Opioid Analgesic Treatment, Shriya Doranala

Honors Undergraduate Theses

Pain management agreements are increasingly used in the treatment of chronic pain with opioid analgesics. These agreements aim to reduce misuse of opioids by providing patients clear regulations and requirements to follow during treatment. This study seeks to assess the effect of pain management agreement for opioid treatment on the patient-physician relationship from the perspective of patients with a pain management agreement in the past two years. We recruited participants for the semi-structured interview through online media groups dedicated to patients with chronic pain that is treated with opioids. A cohort of eight individuals recruited from September 2023 to January …

How To Save A Life: The Impact Of Death Prevention Education Including Cardiopulmonary Resuscitation And Hemorrhage Control On Adolescents, Emily Charlton

Nursing | Senior Theses

Background: Out of hospital cardiac arrest (OHCA) and uncontrolled traumatic bleeding are two of the leading causes of death globally. Death due to OHCA and bleeding is largely preventable. With appropriate bystander intervention, positive outcomes in cases of OHCA and traumatic bleeding would greatly increase. Purpose: Bystander ability and intent to provide emergency cardiopulmonary resuscitation (CPR) and bleeding control is dependent on educational programs including death prevention first aid. Upon review of research, a gap was identified in adolescent death prevention training. The purpose of this proposed prospective study is to determine the effect of a high school education curriculum …

The Effects Of Medical Misinformation About Vaccines On Parents Of Pediatric Patients, Mya Izabela B. Emelia

Nursing | Senior Theses

Abstract

Purpose

The purpose of this study is to evaluate the effectiveness of an educational intervention designed for parents of pediatric patients who are vaccine hesitant and its impact on childhood vaccination rates. This research proposal aims to assess whether targeted education addressing vaccine misinformation, safety concerns, and benefits influences parental decision-making and improves vaccine uptake.

Methods

Parents of pediatric patients will be recruited from pediatric clinics and community health centers. Participants will complete a baseline survey before receiving an educational intervention addressing vaccine misinformation, social media-driven misconceptions, and hesitancy. A post-intervention survey will then assess changes in vaccine hesitancy, …

Infant Health Equity In Oklahoma: A Mixed-Methods Exploration Of Personal, Organizational, Environmental, And Policy Factors Contributing To Black Infant Mortality, Ayesha M. Lampkins

West Chester University Doctoral Projects

Black women experience higher rates of adverse birth outcomes, including infant mortality. There is a gap in the literature on multilevel strategies to achieve infant health equity and engage Black women. This study is unique in that no others have looked at the views of Oklahoma Black women to inform and address infant health equity strategies and utilize these views to provide context to existing infant mortality data. The study research questions are: 1) What views on infant health equity and infant mortality are held by Black women in Oklahoma? 2) What differences exist between Black and White mothers in …

Enhancing Wellbeing Through Caregiver Support: Improving Quality Of Life For Individuals With Special Needs And Complex Medical Diagnoses In Nicaragua, Jenna K. Devchand

Entry-Level Occupational Therapy Doctorate - Doctoral Capstone Symposium

Individuals with disabilities living all over the world are constantly faced with additional barriers. In low-income countries, such as Nicaragua, there is often a gap in access to resources and education, for both individuals living with disabilities and their caregivers. Access is essential to provide high quality care to meet unique needs. This occupational therapy doctoral capstone project was created to support individuals providing care to children with special needs and complex medical diagnoses in Nicaragua by providing community-based education and sustainable resources to caregivers to enhance wellbeing in daily life. The deliverable was presented in country in Nicaragua to …

Factors Driving Potentially Preventable Hospitalizations In Ohio And Surrounding States, Ann Walter, Andy Russell

Scholarship in Medicine - All Papers

No abstract provided.

An Analysis Of Alcohol, Mental Health, And Suicide, Motassem Bayyoud, Megan Galluch

Scholarship in Medicine - All Papers

Suicide rates in Montana, Iowa, Ohio, and New Jersey vary strongly and encompass the wide range seen across all fifty states in America. Previous research has told us that there is a significant relationship between Alcohol Use Disorder and the ideation, attempt, and completion of suicide. Additionally, most people who are victims of suicide suffer from mental disorders. People use alcohol to cope with mental health and alcohol leads to deteriorating and adverse outcomes in a person’s life. To attempt to better understand the relationship between these variables and why suicide rates differ so widely, an analysis of binge drinking, …

Exploring The Socioeconomic Drivers Of Type 2 Diabetes Mellitus Prevalence And Their Implications For Treatment In The Midwest, Kendall Locascio, Anirudha Koppaka

Scholarship in Medicine - All Papers

Type 2 Diabetes Mellitus (T2DM) is a leading chronic disease globally with its prevalence steadily rising and significantly impacting public health systems. Previous research has indicated correlations between resource scarcity, low income, and limited education completion and T2DM prevalence. However, the degree of influence of these factors on incidence and progression remains unclear. This study aims to identify the most significant socioeconomic determinants of T2DM prevalence and progression in the Midwest to aid healthcare providers in creating maximally effective T2DM treatment plans. Methods include using data from County Health Rankings & Roadmaps (CHR&R) for Ohio, Illinois, Indiana, and Michigan. We …