Digital Commons Network^™

Phase Ii Study Of Vemurafenib In Children And Young Adults With Tumors Harboring Braf V600 Mutations: Nci-Cog Pediatric Match Trial (Apec1621) Arm G, Marie V Nelson, Aerang Kim, P Mickey Williams, Sinchita Roy-Chowdhuri, David R Patton, Brent D Coffey, Joel M Reid, Jin Piao, Lauren Saguilig, Todd A Alonzo, Stacey L Berg, Nilsa C Ramirez, Alok Jaju, Elizabeth Fox, Brenda J Weigel, Douglas S Hawkins, Margaret M Mooney, Naoko Takebe, James V Tricoli, Katherine A Janeway, Nita L Seibel, D Williams Parsons

Center for Medical Ethics and Health Policy Staff Publications

Background: This is a phase II subprotocol of the NCI-COG Pediatric MATCH study evaluating vemurafenib, a selective oral inhibitor of BRAF V600 mutated kinase, in patients with relapsed or refractory solid tumors harboring BRAF V600 mutations.

Methods: Patients received vemurafenib at 550 mg/m2 (maximum 960 mg/dose) orally twice daily for 28-day cycles until progression or intolerable toxicity. The primary aim was to determine the objective response rate and secondary objectives included estimating progression-free survival and assessing the tolerability of vemurafenib.

Results: Twenty-two patients matched to the subprotocol and 4 patients (18%) enrolled. Primary reasons for non-enrollment were ineligibility due to …

Teaching Shakespeare In Prison, Renford Reese, Rachel Tracie

Journal of Prison Education Research

The Prison Education Project (PEP) offers life skills and academic courses in 30 correctional facilities in California. Founded in 2011, PEP uses university student and faculty volunteers to teach a range of 32 introductory courses during three seven-week semesters: Fall, Spring, Summer. One of PEP’s most popular courses is the “Introduction to Shakespeare” course. This article examines the impact of teaching an “Introduction to Shakespeare” course in prison. This course introduces in-custody students to the literary interpretation of Shakespeare in the context of their own lived experience. Students in this course deconstruct the use of language and analyze the social, …

Socioeconomic Inequalities Between The Bronx And Other Counties In New York City, Mexican Studies Institute Cuny, Eliana Checo-Genaoa

CUNY Mexican Studies Institute

The Bronx, despite its proximity to the other boroughs of New York City, has the highest poverty rates among them. Using data from 2010 to 2022, this study examines the socioeconomic disparities between the Bronx and Brooklyn, Manhattan, Queens, and Staten Island. Key indicators analyzed include poverty levels, SNAP benefits, unemployment rates, median income, educational attainment, homeownership rates, business creation, and GDP per capita. Our study reveals that the Bronx has the highest poverty, unemployment, and SNAP benefit dependency rates, lower educational attainment, and the lowest median income and homeownership rates. Our findings underscore the persistent socioeconomic challenges faced by …

Heirs Property And The Necessary Role Of Extension In Preventing Land Loss Through Partitioning, Kurt Smith

Journal of Extension

Land loss in the United States continues to be a threat to our inventory of natural resources. The problem of co-tenancy or heirs’ property is a particular and persistent problem throughout the United States leading to fragmentation of property, and the complete loss of forest and farmland. Maintaining enough forest and farmland is essential to local, regional, and international economies. Much can be done to ameliorate the problem through education about the value of successional planning and the requirements of your state regarding the legal practice known as partitioning.

Participatory Democracy: The Potential For Civic Transformation Understanding Participants' Learning In The Milwaukie Citizens Jury, Amanda Grace Hudson

Dissertations and Theses

Faced with unresponsive government institutions and the limitations of representative democracy, participatory and deliberative democrats have created alternative models for robust democratic participation such as civic juries, civic assemblies and participatory budgeting. Advocates claim that these methods create better citizens and better outcomes and they claim these forums act as a school of democracy. The schools of democracy theory describes participation as a virtuous circle--that doing democracy will make people more democratic. While these processes often produce enthusiastic supporters and encouraging results, there has been very little research to date that attempts to explain how and why people learn and …

Reflecting On, Resetting, And Reimagining Schools In The Post-Pandemic Context: A Case Study In Rural Vermont, Rachel A. Glickman

Dissertation Collection

This qualitative study examines the experiences of public elementary teachers and school leaders to better understand the shifting of educational priorities during the COVID-19 pandemic. Participants share ideas and practices while taking action steps and making recommendations to improve teaching and learning. The research incorporates both case study and action research approaches through a critical inquiry process that centers the voices of those on the front lines of education. This study contributes to the field of Comparative and International Education (CIE) using the original conceptual framework of Institutional Border Theory of Education (IBTE). IBTE draws on pre-existing foundational theories of …

Financing Just Energy Transitions In Southeast Asia: Application Of The Just Transition Transaction To Indonesia, Vietnam, And Philippines, Abhinav Jindal, Gireesh Shrimali, Bharat Gangwani, Rajiv B. Lall

Sim Kee Boon Institute for Financial Economics

This paper investigates the applicability of the Just Transition Transaction (JTT), initially developed as a financial mechanism for South Africa's energy transition, to Southeast Asian (SEA) countries, including Indonesia, Vietnam, and the Philippines, which heavily rely on coal. Utilizing South Africa as a reference case study, we deconstruct the JTT and develop a novel framework of necessary and conducive features for evaluating its suitability for supporting a just energy transition in SEA. Our findings suggest that the JTT is well-suited for Indonesia and Vietnam but not as well suited for the Philippines. Recommendations for specific research avenues in estimating baselines …

Research Report: Well-Being, Heather Akin, Cheryl A. Burkhart-Kriesel, Mary Emery, Katelyn Larson, Bradley Lubben, L. J. Mcelravy, Rebecca J. Vogt

Nebraska Rural Poll

This year, rural Nebraskans are more pessimistic about their current situation than they’ve been since this study began. The proportion believing they are worse off than they were five years ago was 33 percent, up from 27 percent last year and 21 percent in 2022. This is the highest level across all years of the study. This increase in pessimism was matched with a sharp decrease in optimism. This year, just over one-third (36%) of rural Nebraskans believe they are better off compared to five years ago, down from 45 percent last year.

This trend continued when looking to the …

Policy Brief—Safeguarding Women's Health: Trends, Inequities, And Opportunities In Pakistan's Abortion And Postabortion Care Services, Population Council, Guttmacher

Safe Abortion and Postabortion Care

Pakistan is experiencing critical reproductive health issues driven by a high population growth rate of 2.55% per year, low contraceptive use (34% for all methods, 23.4% for modern methods), and a significant unmet need for family planning (17.3%). Low contraceptive use and high unmet need for family planning contribute to high rates of unintended pregnancies which often result in unsafe abortions and postabortion complications.

This policy brief presents the findings of a comprehensive study on abortion and postabortion care in Pakistan. The study was conducted in 2023 by the Population Council in partnership with the Guttmacher Institute. The study is …

Criminal Justice Update - August 2024, Sophia Dotterweich

Criminal Justice Updates

The Criminal Justice Update is a monthly newsletter created by the Adams County Bar Foundation Fellow providing updates in criminal justice policy coming from Pennsylvania's courts and legislature as well as the US Supreme Court.

Contents:

• Updates from PA Governor's Office (no updates this month)
• Updates from the PA Legislature (no updates this month)
• Updates from the Courts
• U.S. Supreme Court: Criminal Law & Procedure (no updates this month)
• PA Supreme Court: Criminal Law & Procedure
• PA Superior Court: Criminal Law & Procedure

Scooting Through Urban Shared Micromobility Transformations: A Comprehensive Study Of Shared E-Scooter Usage Patterns, Pandemic Effects, And Equity Challenges, Farzana Mehzabin Tuli

Graduate Theses and Dissertations

The rise of shared e-scooters has sparked a paradigm shift in urban transportation, offering a flexible mode of micromobility for short-distance travel. Since their US debut in September 2017, these electric scooters have gained popularity, surpassing traditional bikesharing services in many cities. This dissertation presents four studies that delve into various aspects of e-scooter adoption, from user behavior and pandemic effects to gender disparities and equitable access, providing comprehensive insights for urban mobility planning. The first study aims to determine (i) who uses shared e-scooters and why they use them, and (ii) what effects e-scooters have on the usage of …

How Can Event Attribution Science Underpin Financial Decisions On Loss And Damage?, Dim Coumou, Paola A. Arias, Ana Bastos, Charlotte Kendra Z. Gotangco Gonzales, Gabriele C. Hegerl, Pandora Hope, Christopher Jack, Friederike Otto, Fahad Saeed, Olivia Serdeczny, Theodore G. Shepherd, Robert Vautard

Environmental Science Faculty Publications

With climate extremes hitting nations across the globe, disproportionately burdening vulnerable developing countries, the prompt operation of the Loss and Damage fund is of paramount importance. As decisions on resource disbursement at the international level, and investment strategies at the national level, loom, the climate science community’s role in providing fair and effective evidence is crucial. Attribution science can provide useful information for decision makers, but both ethical implications and deep uncertainty cannot be ignored. Considering these aspects, we articulate a vision that integrates established attribution methods and multiple lines of evidence within a coherent logical framework.

20,000 Ft. View: An Introduction To Emergency Management, Bethany Swindell, Jamie Stacy

ATU Faculty OER Books and Materials

This book adopts a "20,000-foot view" approach, offering an essential understanding of emergency management without delving into operational specifics. It doesn't detail day-to-day practices of emergency management offices. Instead, it paints a high-level portrait of the field's core principles. This approach equips readers with a broad framework—a canvas onto which they can later add layers of specialized knowledge.

Housing Policy And Eviction: An Iterative Process., Oleksandra Maksymivna Belinova

Electronic Theses and Dissertations

Previously, eviction has been perceived as a legal problem rather than a social issue. Previous literature examines eviction as a social problem and the role of program administrators in policy implementation. Through a mixed-methods study of in-depth semi structured interviews and secondary descriptive analysis of eviction data, this study serves explores program administrators’ perspectives on housing policy and eviction practices and the impact these perspectives have on policy implementation and eviction prevention. The results indicate that program administrators view eviction as a legal phenomenon influenced by housing market dynamics with eviction prevention efforts limited by data collection and the lack …

Coproduction Revisited: From Theory To Practice., Brenton Clarke Hereford

Electronic Theses and Dissertations

Coproduction, or the interaction of citizens with their public service provider, has been used in policy responses to a myriad of service delivery problems, especially policing. This dissertation uses a three-manuscript approach to revisit coproduction both as a theory and a practice. The first manuscript tracks the evolution of coproduction as a theory from three different disciplines: economics, urban theory, and public administration. In addressing the three disciplines, the manuscript explains what broadly united the coproduction literature and the differences that hindered the early development of the concept. It concludes with how the concept is used today, and how future …

Safeguarding Women's Health: Trends, Inequities, And Opportunities In Pakistan's Abortion And Post-Abortion Care Services, Ali M. Mir, Zeba Sathar, Iqbal Shah, Rehan M. Niazi, Tahira Parveen, Susheela Singh

Safe Abortion and Postabortion Care

This report presents the findings of a comprehensive study on abortion and post-abortion care in Pakistan, conducted in 2023 by the Population Council in partnership with the Guttmacher Institute. The study addresses a critical need for updated information on women's reproductive health in Pakistan, a country facing significant challenges including a high population growth rate (2.55% per annum), low contraceptive use (34% for any method, 23.4% for modern methods), and a high unmet need for family planning (17.3%). The study is the third of its kind since 2002, building on previous research conducted in 2002 and 2012. It comes at …

Project Turnkey Evaluation, Anna Rockhill, Sarah Mercurio, Franklin Holcomb Spurbeck

Homelessness Research & Action Collaborative Publications and Presentations

In 2020-2021 Oregon legislators approved $74.7 million to assist communities to purchase local motels and convert them into emergency shelters. The goal was to help keep people safe during COVID and to address the need for housing for victims of the wildfires in light of the deficit of appropriate shelter resources facing the state. A total of 19 projects received funding, and by 2023 all of the projects were providing services to people experiencing homelessness. Combined, this resulted in 865 new units of emergency shelter-- a 20% increase in the state’s supply. According to an analysis done by Oregon Community …

Recreational Cannabis In Louisiana: Anticipating Potential Risks For Motor Vehicle Safety In The Short And Long Term, Aimee H. Moles, Andrew Burns, Ashley Tillison, Austin L. Matthews

Reports

This document, titled Recreational Cannabis in Louisiana: Anticipating Potential Risks for Motor Vehicle Safety in the Short and Long Term, provides a comprehensive analysis of the potential impacts that cannabis legalization could have on road safety in Louisiana. The document is written to equip policymakers and concerned citizens with the necessary knowledge to navigate the complex landscape of cannabis legalization and its implications for public safety.

Key Objectives and Scope: The primary purpose of this document is to evaluate the potential risks associated with recreational cannabis legalization on motor vehicle safety, drawing on data and experiences from Canada and states …

Aging In Newton: A Community Needs Assessment, Claire Wickersham, Katherine Burnes, Shu Xu, Caitlin E. Coyle

Center for Social and Demographic Research on Aging Publications

This report presents the results of a comprehensive examination of issues relating to aging in Newton. A needs assessment was undertaken to support planning on the part of the City of Newton and the Department of Older Adult Services. Results presented here focus on the characteristics and needs of Newton residents who are aged 60 and older. Data was collected via key informant interviews, focus groups with residents and stakeholders and a mailed survey of residents aged 60 and older. Respondents to the community survey included 2,869 Newton residents, which resulted in a response rate of more than 50%. As …

Book Review: Poor Atlanta: Poverty, Race, And The Limits Of Sunbelt Development, Michael Camp

Georgia Library Quarterly

No abstract provided.

Carceral Degrees: Successful Postsecondary Educational Pathways For Students Impacted By The Criminal Justice System In Maine, Mara Sanchez Phd

Muskie School Capstones and Dissertations

The benefits of postsecondary degrees are striking for populations who have experienced incarceration, yet little is understood about how this population succeeds with educational attainment upon release from incarceration. This qualitative collective case study examined to what extent and how six formerly incarcerated individuals who started educational programming while incarcerated successfully persisted with postsecondary degrees after being released back into Maine communities. This study found that participants related education to self-care or treatment, described their own education journeys as different, or taking a different path, and felt motivated to persist with education despite external expectations, which one participant labeled “transformational …

A Study Of The Impact And Mitigation Strategies For Community-Defined Historic Places At Immediate (Within Three Decades) Risk Of Sea Level Rise, Isaac Quaye

All Theses

The rising sea level casts formidable threats on community-based historic places within coastal communities. These community-defined historic places derive their meaning from local values and are more recognized within the local community. Unlike recognized iconic historic places, these resources are confronted with inadequate resources to address the impacts of punctuated climate events. This study investigates the imminent threats posed by sea level rise (SLR) to community-defined historic places within the next three decades (2025) and explores mitigation strategies proposed by stakeholders. The study used a GIS-based (enhanced bathtub model) to model the impact of coastal inundation on three historic places …

Transforming Grassland Conservation: Challenges And Opportunities Across Law, Policy, And Human Dimensions, Conor D. Barnes

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Great Plains social-ecological systems are facing growing pressure from complex, ‘wicked’ problems. Addressing these problems will require integrating ecological resilience and complex systems thinking concepts into our legal framework in order to better reflect the changing ecological reality of the Great Plains and promote flexibility and adaptability in the face of that change. In this dissertation, I examine how past and present policy priorities have affected social-ecological systems on the Great Plains, and how ecological resilience and complex systems thinking might be applied to grassland management policy. In Chapter 2, I examine the rapid progress made in the adoption of …

Further Developing Drought Early Warning Information Systems Using Mixed-Methods And Multiple Streams Of Data, Caily Claire Schwartz

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Drought is a complex phenomenon with varying degrees of impacts and monitoring methods. No drought is alike, creating a challenge for both water managers and communities. No area is immune to a drought. Due to the cyclical nature of drought events, clear information to those impacted is necessary to reduce risk and move towards proactive responses, as opposed to reactive responses. To better provide communication and mitigation tools, Drought Early Warning Information Systems (DEWIS) have been developed in various regions and contexts. To improve early warning, an understanding of the end user’s perceptions of risk, and the applicability of data …

Applying Circuit Theory To Describe Changes In Structural Landscape Connectivity In Response To Wildfire, Christian Ross Nielsen

School of Natural Resources: Dissertations, Theses, and Student Research

Understanding and conserving ecological connectivity is critical to the preservation of vulnerable landscapes. Circuit theory, in which landscapes are imagined as circuit boards with varying resistances to the flow of current, is being increasingly used to model spatially explicit connectivity of landscapes and to inform land management and conservation decision-making. Utilizing continuous, quantitative estimates of percent cover by five land cover functional groups to create a conductance surface, this study expanded upon an established application of circuit theory that used the open-source software Circuitscape to model species-agnostic, omnidirectional connectivity. This model was automated using Python to create time-series connectivity maps …

Analysis Of Drought-Flood Abrupt Alternation Events And Their Impacts In Kenya, Betty Makena

School of Natural Resources: Dissertations, Theses, and Student Research

Drought-Flood Abrupt Alternation (DFAA) is a compound disaster event that refers to the abrupt shift of extreme drought events to extreme floods resulting in exacerbated impacts on already vulnerable communities and hindering their coping abilities. This study aimed to analyze drought-flood abrupt alternation events and their impacts in Kenya. The first chapter aimed to understand historical drought events in the Greater Horn of Africa and their impacts, while drawing comparisons with the recent 2020-2022 drought period, referred to as the ‘triple dip La Niña’. Datasets used in this study include the Climate Hazards Group InfraRed Precipitation with Station (CHIRPS), Normalized …

The Growth And Governance Of American Classical And Christian Schools, Cassidy Syftestad Klutts

Graduate Theses and Dissertations

Classical and Christian education has proliferated across education sectors over the last decade. As a result, school leaders must implement these timeless philosophies of education and navigate such high demand. This dissertation seeks to equip relevant parties with research about what drives their skyrocketing enrollment and how to support school leaders and their governing boards. My first chapter uses in-person focus groups to understand the school choices of 25 parents whose children are enrolled in Texas-based classical charter schools. I explore the ways in which parents found their children’s school; what made them enroll their children; and whether they are …

Optimization Of Customer Service And Driver Dispatch Areas For On-Demand Food Delivery, Jingfeng Yang, Hoong Chuin Lau, Hai Wang

Research Collection School Of Computing and Information Systems

With the rapid development and popularization of mobile and wireless communication technologies, on-demand food delivery (OFD) platforms have been able to connect restaurants, customers, and drivers in real time, drastically changing dining and food delivery services. Motivated by the critical need for supply and demand management in the on-demand food delivery market, we focus on the optimization of customer service area and driver dispatch area for on-demand food delivery services. Specifically, for each restaurant, the platform needs to decide the (1) customer service area (CSA), i.e., the surrounding area within which customers can see the restaurant’s information and order food …

Political Constructions Of People Who Use Drugs In The Philippines: A Qualitative Content Analysis, Gideon Lasco

Development Studies Faculty Publications

Background

This paper examines the political constructions of people who use drugs in the Philippines throughout the presidency of Rodrigo Duterte (2016–2022), during which the government engaged in a ‘war on drugs’ and promoted a punitive drug regime.

Methods

Building on and drawing inspiration from the global drug policy scholarship that has looked at the ways in which drugs are framed and problematised in various domains, this study used qualitative content analysis to review 96 documents from national government agencies - including strategic action plans, directives, memorandums, guidelines, annual reports, and legislative measures.

Results

Foremost, the study finds that various …

Redefining Missing In The Third Space Of Sovereignty: Collaborative Governance On Idaho's Missing And Murdered Indigenous Persons Policy, Melanie Fillmore

Boise State University Theses and Dissertations

This three-article dissertation addresses how Indigenous and non-Indigenous state and non-state policy actors collaborating on Idaho missing and murdered Indigenous persons (MMIP) policy shift the Integrative Framework for Collaborative Governance (IFCG) policy context to the ‘third space of sovereignty’ (Bruyneel, 2007). In a space of competing narratives of authority across time, and space, paper one addresses how Indigenous and non-Indigenous policy actors are shaped by the “drivers” of collaboration. The second paper addresses three key configurations of collaborative governance regimes. The third paper reassesses the scope of Idaho MMIP through a comparison of MMIP cases in 2021 and 2023 as …