Digital Commons Network^™

Protecting The Cosmos: Defining Celestial Bodies In The Outer Space Treaty, David Epstein

Space and Defense

Lack of a clear definition of the term “celestial bodies” as used in the 1967 Outer Space Treaty risks exporting legal and political conflict into the cosmos. *This essay is updated from a previously published version and appears here by permission of the Journal of Space Law at Ole Miss.

American Sanctions On China's Space Program: Effective Economic Statecraft?, Paul J. Bolt

Space and Defense

American economic statecraft as a tool to manage competition with China’s Space Program is likely to remain contentious as it amplifies enduring debates in U.S. foreign policy: i) the tension between international realism and American liberalism; ii) the questionable benefit of government involvement in picking winners and losers from the private sector; and iii) the difficulty of defining long-term success in foreign policy outcomes.

Graduates Of Southern Nevada Public High Schools And Unlv, 2010-2022, Caitlin J. Saladino, William E. Brown Jr.

Higher Education

This fact sheet reports data for individuals who earned both a diploma from a high school in Southern Nevada and a bachelor’s degree at the University of Nevada, Las Vegas (UNLV) between 2010 and 2022, as well as the race/ethnicity and gender of these graduates.

Trust Criteria For Artificial Intelligence In Health: Normative And Epistemic Considerations, Kristin Kostick-Quenet, Benjamin H Lang, Jared Smith, Meghan Hurley, Jennifer Blumenthal-Barby

Center for Medical Ethics and Health Policy Staff Publications

Rapid advancements in artificial intelligence and machine learning (AI/ML) in healthcare raise pressing questions about how much users should trust AI/ML systems, particularly for high stakes clinical decision-making. Ensuring that user trust is properly calibrated to a tool's computational capacities and limitations has both practical and ethical implications, given that overtrust or undertrust can influence over-reliance or under-reliance on algorithmic tools, with significant implications for patient safety and health outcomes. It is, thus, important to better understand how variability in trust criteria across stakeholders, settings, tools and use cases may influence approaches to using AI/ML tools in real settings. As …

Nevada Medical Residencies, 2024, Annie Vong, Caitlin J. Saladino, William E. Brown Jr.

Health

This fact sheet highlights medical residency data for the 2021, 2022, 2023, and 2024 graduating classes of the Kirk Kerkorian School of Medicine at the University of Nevada, Las Vegas (UNLV) and the University of Nevada, Reno (UNR) School of Medicine. This fact sheet presents data on residency program matches at the Kirk Kerkorian School of Medicine at UNLV and the UNR School of Medicine and reveals where Nevada medical school graduates pursue their residencies, and updates findings from a 2023 fact sheet exploring 2021, 2022, and 2023 graduating class data.

Average Child Care Costs In Nevada And The Mountain West, 2024, Monserrat Cristando-Romo, Maryam Raja, Annie Vong, Caitlin J. Saladino, William E. Brown Jr.

Economic Development & Workforce

This fact sheet reports data on the average costs of child care in the five most populous cities in each Mountain West state and the ten most populous cities in Nevada based on the “2020: ACS 5-Year Estimates Data Profiles” United States Census Bureau (Salt Lake City, UT; Albuquerque, NM; Denver, CO; Phoenix, AZ; and Las Vegas, NV). The original report from care.com provides child care data for all U.S. cities to assess the costs of child care nationally.

Analyzing The Legitimacy, Effectiveness, And Legacy Of The United Nations, Hunter Wade Calley

Dissertations and Theses

This thesis examines the legitimacy and effectiveness of the United Nations since its establishment, while also exploring the shortcomings of its predecessor, the League of Nations. The legitimacy of the United Nations and the role the organization plays in the world of international politics, the flaws of the UN Security Council, and the impact of the Cold War on the legitimacy and processes of the United Nations are especially highlighted throughout this thesis.

The successes and shortcomings of the United Nations are best understood given the historical context of the League of Nations, the organization founded to bring world powers …

Black-Owned Businesses In The Mountain West, 2017-2020, Riley Ruff, Miguel Soriano Ralston, Caitlin J. Saladino, William E. Brown Jr.

Economic Development & Workforce

This fact sheet examines data on Black-owned businesses in the Mountain West states of Arizona, Colorado, Nevada, New Mexico, and Utah. The report “Who is driving Black business growth? Insights from the latest data on Black- owned businesses" from the Brookings Institution includes data on Black-owned businesses in metropolitan statistical areas (MSAs) across the United States.

Karnataka Government Must Revisit Gig Workers Bill, Make It More Inclusive, Babu Mathew, Saurabh Bhattacharjee, Madhulika T

Popular Media

The Karnataka Platform-Based Gig Workers (Social Security and Welfare) Bill, 2024 has been favourably received by several commentators, but a closer inspection of the text of the Bill reveals glaring omissions, which if left unaddressed are likely to undermine the Bill’s objectives.

Indigenous Practices In Head Start Classrooms— Toward Survivance And Indigenization In Policy And Practice, Liza Xet Smith

LMU Theses and Dissertations

The Office of Head Start has prioritized holistic quality education services for children and communities in greatest need. First, since 1965, the federal government has funded, regulated, and publicly aided over 38 million children through Head Start programming, including AIAN and Migrant programs (Administration for Children and Families, n.d.). In 2019, over $10 billion was budgeted for the program, resulting in 1,047,000 low-income children and their families receiving services (Office of Head Start, 2022a). In addition, the Office of Planning, Research, and Evaluation has funded research to improve quality and child outcomes, with research recommendations that significantly guide state and …

U.S. News & World Report 2024 Graduate Program Rankings, Unlv & Unr, Madison Dwyer, Caitlin J. Saladino, William E. Brown Jr.

Higher Education

This fact sheet presents 2024 graduate program rankings for the University of Nevada, Las Vegas (UNLV) and for the University of Nevada, Reno (UNR) based on the data published in spring 2024 by U.S. News and World Report. The graduate program categories reported include business, education, engineering, fine arts, law, medicine and health care, sciences and mathematics, and social sciences and humanities.

Chimeric Antigen Receptor-Induced Antigen Loss Protects Cd5cart Cells From Fratricide Without Compromising On-Target Cytotoxicity, Royce Ma, Mae Woods, Phillip Burkhardt, Noah Crooks, Dayenne G Van Leeuwen, Daniil Shmidt, Jacob Couturier, Alexandre Chaumette, Divya Popat, Laquisa C Hill, Rayne H Rouce, Sachin Thakkar, Aaron F Orozco, Alexandre F Carisey, Malcolm K Brenner, Maksim Mamonkin

Center for Medical Ethics and Health Policy Staff Publications

Chimeric antigen receptor T cells (CART) targeting lymphocyte antigens can induce T cell fratricide and require additional engineering to mitigate self-damage. We demonstrate that the expression of a chimeric antigen receptor (CAR) targeting CD5, a prominent pan-T cell antigen, induces rapid internalization and complete loss of the CD5 protein on T cells, protecting them from self-targeting. Notably, exposure of healthy and malignant T cells to CD5.CART cells induces similar internalization of CD5 on target cells, transiently shielding them from cytotoxicity. However, this protection is short-lived, as sustained activity of CD5.CART cells in patients with T cell malignancies results in full …

Impact Of Efavirenz On Hormone-Positive Breast Cancer Survival In Women Living With Hiv, Arthur T Johnson, Taolo Ntloedibe, Jose Euberto Mendez Reyes, Mogomotsi S Matshaba, Scott L Dryden-Peterson, Elizabeth Y Chiao

Center for Medical Ethics and Health Policy Staff Publications

Women living with HIV and breast cancer have poorer survival than HIV-negative women. Efavirenz-estrogen interactions are documented; however, the survival impact is unknown. Survival between women with estrogen-receptor positive breast cancer taking efavirenz (n = 38) and nonefavirenz regimens (n = 51) were compared. The 5-year overall-survival was 48.9% [95% confidence interval (CI) 33.0-72.2 and 51.1% (95% CI 34.0-76.8)] in the efavirenz and nonefavirenz groups, respectively suggesting efavirenz is unlikely driving poorer survival in women living with HIV and estrogen-receptor positive breast cancer.

Developing Public-Private R&D Consortia To Accelerate Alzheimer’S Disease Drug Development, Joel West, Paul Olk

Management: Faculty Scholarship

Efforts to accelerate Alzheimer's disease (AD) drug development have been spurred on by the creation of open science, public-private R&D consortia. An R&D consortium provides an improved structure for generating and disseminating AD knowledge across a range of organizations while also aligning their interests. Drawing from archival and interview data collected on 46 public-private R&D consortia focused wholly or in part on AD, we uncover two important innovations: the creation of novel consortium types that facilitate coordination beyond the individual consortium, and the practice of organizations joining multiple consortia. Collectively these innovations provide member organizations with different pathways for advancing …

Criminal Justice Practitioners Perceptions On Collateral Consequence Policies Affecting Formerly Incarcerated African American Males, Ronnie Devon Williams

Walden Dissertations and Doctoral Studies

Formerly incarcerated African American males have a challenging time transitioning back into the community due to invisible barriers that impede their opportunities for successful reintegration. This generic qualitative study aimed to explore criminal justice practitioners' perceptions regarding collateral consequence policies for formerly incarcerated African American males. The theoretical framework for the study was labeling theory, which explained how others stigmatize individuals due to their social and environmental characteristics. The research question guiding this study was how criminal justice practitioners perceived the impact of collateral consequence policies on the successful reintegration of African American males. Ten criminal justice practitioners including probation …

National Narcotics Policy Influence On Youth Substance Abuse In Yendi, Ghana, Imran Abdel-Rahman Gomdah

Walden Dissertations and Doctoral Studies

Possession of small quantities of narcotics for personal use in Ghana could result in years in detention under the Narcotic Drugs Law of 1990, with youth constituting a large number of offenders. The government proposed a drug policy change in 2017 as the prevailing one failed to achieve its goals even with such stringency, resulting in Act 1019’s adoption in May 2020 as a new national drug policy to replace the Narcotic Drugs Law of 1990. The purpose of this generic qualitative study was to assess public perception of the impact of the new policy on the incidences of youth …

The Impact Of Clinical Genome Sequencing In A Global Population With Suspected Rare Genetic Disease, Erin Thorpe, Taylor Williams, Chad Shaw, Evgenii Chekalin, Julia Ortega, Keisha Robinson, Jason Button, Marilyn C Jones, Miguel Del Campo, Donald Basel, Julie Mccarrier, Laura Davis Keppen, Erin Royer, Romina Foster-Bonds, Milagros M Duenas-Roque, Nora Urraca, Kerri Bosfield, Chester W Brown, Holly Lydigsen, Henry J Mroczkowski, Jewell Ward, Fabio Sirchia, Elisa Giorgio, Keith Vaux, Hildegard Peña Salguero, Aimé Lumaka, Gerrye Mubungu, Prince Makay, Mamy Ngole, Prosper Tshilobo Lukusa, Adeline Vanderver, Kayla Muirhead, Omar Sherbini, Melissa D Lah, Katelynn Anderson, Jeny Bazalar-Montoya, Richard S Rodriguez, Mario Cornejo-Olivas, Karina Milla-Neyra, Marwan Shinawi, Pilar Magoulas, Duncan Henry, Kate Gibson, Samuel Wiafe, Parul Jayakar, Daria Salyakina, Diane Masser-Frye, Arturo Serize, Jorge E Perez, Alan Taylor, Shruti Shenbagam, Ahmad Abou Tayoun, Alka Malhotra, Maren Bennett, Vani Rajan, James Avecilla, Andrew Warren, Max Arseneault, Tasha Kalista, Ali Crawford, Subramanian S Ajay, Denise L Perry, John Belmont, Ryan J Taft

Center for Medical Ethics and Health Policy Staff Publications

There is mounting evidence of the value of clinical genome sequencing (cGS) in individuals with suspected rare genetic disease (RGD), but cGS performance and impact on clinical care in a diverse population drawn from both high-income countries (HICs) and low- and middle-income countries (LMICs) has not been investigated. The iHope program, a philanthropic cGS initiative, established a network of 24 clinical sites in eight countries through which it provided cGS to individuals with signs or symptoms of an RGD and constrained access to molecular testing. A total of 1,004 individuals (median age, 6.5 years; 53.5% male) with diverse ancestral backgrounds …

Employees Speak Up: Engaging Voices From The Human Services Field, Henry J. Davis, Janna C. Heyman, Linda White-Ryan, Dana Marlowe

The Journal of Values-Based Leadership

This qualitative study aims to understand the perceptions and experiences of human services professionals working within urban communities with respect to their work experiences, compensation, and work-life balance. Focus groups were used to collect data from direct service staff and executive leadership from diverse agencies. This study examined the words and stories, generating the following overarching themes: (1) dedication to agency model and communities served; (2) compensation and responsibilities; (3) reality of work-life balance; and (4) desire for professional growth and personal growth. The results show that while employees expressed personal fulfillment with their work, the issues of compensation, workload, …

Research Review: "A Novel Mind-Body Podcast Program For Military And Veteran Caregivers", Institute For Veterans And Military Families At Syracuse University

Institute for Veterans and Military Families

This research review discusses how mind-body interventions can alleviate stress and enhance health for caregivers, but they are not widely accessible in many communities. To overcome this limitation, a study converted an 8-week mind-body program into a 28-day daily podcast series featuring education on stress response, relaxation techniques, and self-compassion exercises. The program was tested with 55 military caregivers, all cisgender women averaging 42.3 years old, and evaluations at the start, halfway through, and at the end of the program revealed notable reductions in stress, depression, and physical issues, along with improved social role performance, indicating that a daily mind-body …

Atrocity Prevention In The Digital Era: Adapting Norms, Laws, And Code To Changes In The Ways Atrocities Are Committed, David J. Simon, Samhitha Josyula, Joshua Lam, Julian D. Melendi

Genocide Studies and Prevention: An International Journal

Emerging digital technologies have changed some of the ways that genocides are planned and executed. This paper examines those differences, calling attention to how changes in the execution of genocide should prompt a shift in the approaches to atrocity prevention. It develops a conceptual framework addressing how atrocity prevention efforts might adapt to new technology within three realms of potential prevention efforts: the ethical (norms), the legal (laws), and the digital (code).

Adopting Oer Course Materials: Instructor Experiences, Jenny Ceciliano

Dissertations and Theses

Traditional commercial textbooks used in postsecondary courses are often problematic due to their rigidity, tendency to mirror the dominant culture, and the substantial cost imposed upon students. Although replacing these texts with open educational resources (OER) can facilitate more equitable and inclusive pedagogical practices while removing a significant expense, there has been insufficient research surrounding instructors' experience of transitioning from a commercial textbook to OER course materials. Through semi-structured interviews with nine postsecondary instructors who teach with OER course materials, this basic qualitative study explores the experience of that transition. The findings indicate that adopting OER is a challenging and …

Olaparib For Childhood Tumors Harboring Defects In Dna Damage Repair Genes: Arm H Of The Nci-Cog Pediatric Match Trial, Julia L Glade Bender, Kerice Pinkney, Paul M Williams, Sinchita Roy-Chowdhuri, David R Patton, Brent D Coffey, Joel M Reid, Jin Piao, Lauren Saguilig, Todd A Alonzo, Stacey L Berg, Nilsa C Ramirez, Elizabeth Fox, Brenda J Weigel, Douglas S Hawkins, Margaret M Mooney, Naoko Takebe, James V Tricoli, Katherine A Janeway, Nita L Seibel, Donald W Parsons

Center for Medical Ethics and Health Policy Staff Publications

Background: The National Cancer Institute-Children's Oncology Group Pediatric Molecular Analysis for Therapy Choice (MATCH) precision oncology platform trial enrolled children aged 1-21 years with treatment-refractory solid tumors and predefined actionable genetic alterations. Patients with tumors harboring alterations in DNA damage repair (DDR) genes were assigned to receive olaparib.

Methods: Tumor and blood samples were submitted for centralized molecular testing. Tumor and germline sequencing were conducted in parallel. Olaparib was given twice daily for 28-day cycles starting at a dose 30% lower than the adult recommended phase 2 dose (RP2D). The primary endpoint was the objective response.

Results: Eighteen patients matched …

Observing Cairene Narratives And Subjectivities Towards Covid-19: Reflections On The First Year Of The Pandemic, Sarra Moneir

Future Journal of Social Science

Theoretical and methodological toolkits already existing in the field of political science and social science in the grand sense have been challenged by the tremendous impacts of waves and movements of social change since 2010 in the Arab Region. While political and social scientists were, and still remain, engaged in unravelling questions of how to apprehend the forms of social movements (re-)born, not just in the Arab world but also through the Occupy movements in the US and Europe, they soon had to redirect their focus on issues of migration and refugees, only to find themselves once again confronted with …

Two Houses Divided? The Parallel Histories Of The Casa De Contratación And The Casa Da Índia, 1500-1580, Gustavo L. Romero

Swarthmore Undergraduate History Journal

This paper seeks to investigate the histories of the Spanish Casa de Contratación and the Portuguese Casa da Índia in relation to one another, identifying possible ways in which each drew inspiration, or imitated the other during the period from 1500 to 1580. Though there is existing research into the individual Casas, comparative approaches have generally been avoided. This work synthesizes the literature and tracks interactions or trends between the Iberian empires from both an institutional and interpersonal perspective. Through analysis of bureaucratic charters, letters, and other documents, it outlines the time periods, possible reasons, and results of this …

York County Rural Communties Opioid Response Implementation Iv Grant: Interim Evaluation Report, Katie Rosingana Ba, Evelyn Ali Bs, Gordon Mcintire Ba, Sarah Mclaughlin Mph, Mary Lindsey Smith Phd

Substance Use Research & Evaluation

This interim evaluation report has been developed for the York County Rural Communities Opioid Response Program, an RCORP-Implementation IV grant awarded to MaineHealth and funded by the Health Resources & Services Administration (HRSA). A main goal of this grant project is to understand the needs of individuals impacted by substance use disorders who have faced structural inequalities to access, in both correctional and heath care settings. The project utilizes a collaborative coalition that is community based, the Rural York Community Coalition (RYCC). For more information, please contact Lindsey Smith at [email protected]

Trans-Ancestral Genetic Risk Factors For Treatment-Related Type 2 Diabetes Mellitus In Survivors Of Childhood Cancer, Cindy Im, Achal Neupane, Jessica L Baedke, Brian Lenny, Angela Delaney, Stephanie B Dixon, Eric J Chow, Sogol Mostoufi-Moab, Tianzhong Yang, Melissa A Richard, M Monica Gramatges, Philip J Lupo, Noha Sharafeldin, Smita Bhatia, Gregory T Armstrong, Melissa M Hudson, Kirsten K Ness, Leslie L Robison, Yutaka Yasui, Carmen L Wilson, Yadav Sapkota

Center for Medical Ethics and Health Policy Staff Publications

Purpose: Type 2 diabetes mellitus (T2D) is a prevalent long-term complication of treatment in survivors of childhood cancer, with marked racial/ethnic differences in burden. In this study, we investigated trans-ancestral genetic risks for treatment-related T2D.

Patients and methods: Leveraging whole-genome sequencing data from the St Jude Lifetime Cohort (N = 3,676, 304 clinically ascertained cases), we conducted ancestry-specific genome-wide association studies among survivors of African and European genetic ancestry (AFR and EUR, respectively) followed by trans-ancestry meta-analysis. Trans-/within-ancestry replication including data from the Childhood Cancer Survivor Study (N = 5,965) was required for prioritization. Three external general population T2D polygenic …

Lethal Phenotypes In Mendelian Disorders, Pilar Cacheiro, Samantha Lawson, Ignatia B Van Den Veyver, Gabriel Marengo, David Zocche, Stephen A Murray, Michael Duyzend, Peter N Robinson, Damian Smedley

Center for Medical Ethics and Health Policy Staff Publications

Purpose: Existing resources that characterize the essentiality status of genes are based on either proliferation assessment in human cell lines, viability evaluation in mouse knockouts, or constraint metrics derived from human population sequencing studies. Several repositories document phenotypic annotations for rare disorders; however, there is a lack of comprehensive reporting on lethal phenotypes.

Methods: We queried Online Mendelian Inheritance in Man for terms related to lethality and classified all Mendelian genes according to the earliest age of death recorded for the associated disorders, from prenatal death to no reports of premature death. We characterized the genes across these lethality categories, …

Post-Trial Responsibilities In Pragmatic Clinical Trials: Fulfilling The Promise Of Research To Drive Real-World Change, Stephanie R Morain, P Pearl O'Rourke, Joseph Ali, Vasiliki Rahimzadeh, Devon K Check, Hayden B Bosworth, Jeremy Sugarman

Center for Medical Ethics and Health Policy Staff Publications

While considerable scholarship has explored responsibilities owed to research participants at the conclusion of explanatory clinical trials, no guidance exists regarding responsibilities owed at the conclusion of a pragmatic clinical trial (PCT). Yet post-trial responsibilities in PCTs present distinct considerations from those emphasized in existing guidance and prior scholarship. Among these considerations include the responsibilities of the healthcare delivery systems in which PCTs are embedded, and decisions about implementation for interventions that demonstrate meaningful benefit following their integration into usual care settings-or deimplementation for those that fail to do so. In this article, we present an overview of prior scholarship …

Testing For Spatial Correlation Under A Complete Bipartite Network, Badi H. Baltagi, Long Liu

Center for Policy Research

This note shows that for a spatial regression with a weight matrix depicting a complete bipartite network, the Moran I test for zero spatial correlation is never rejected when the alternative is positive spatial correlation no matter how large the true value of the spatial correlation coefficient. In contrast, the null hypothesis of zero spatial correlation is always rejected (with probability one asymptotically) when the alternative is negative spatial correlation and the true value of the spatial correlation coefficient is near -1.

Reinforcement Learning For Strategic Airport Slot Scheduling: Analysis Of State Observations And Reward Designs, Anh Nguyen-Duy, Duc-Thinh Pham, Jian-Yi Lye, Nguyen Binh Duong Ta

Research Collection School Of Computing and Information Systems

Due to the NP-hard nature, the strategic airport slot scheduling problem is calling for exploring sub-optimal approaches, such as heuristics and learning-based approaches. Moreover, the continuous increase in air traffic demand requires approaches that can work well in new scenarios. While heuristics rely on a fixed set of rules, which limits the ability to explore new solutions, Reinforcement Learning offers a versatile framework to automate the search and generalize to unseen scenarios. Finding a suitable state observation and reward structure design is essential in using Reinforcement Learning. In this paper, we investigate the impact of providing the Reinforcement Learning agent …