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Preventing War As Ending War: The European Network Remembrance And Solidarity On Channeling Potential Conflict Through Dialogue On History, Rafal Rogulski Jun 2025

Preventing War As Ending War: The European Network Remembrance And Solidarity On Channeling Potential Conflict Through Dialogue On History, Rafal Rogulski

New England Journal of Public Policy

Dialogue about history is an important element in the processes of ordering social and international reality. In the nineteenth and twentieth centuries in Europe alone, we have experienced so many dramas that virtually every country and its citizens have issues in their history that call for prolonged and consistent dialogue, often in an international setting. Colonialism, wars, totalitarian and authoritarian regimes, genocide, forced displacement—we have a lot to talk about in Europe when it comes to history. The establishment and activities of the European Network Remembrance and Solidarity provide an example of how international discourse on history can be conducted …


Black Incarcerated Veterans And Va Service Access, Kimona S. Spencer Jun 2025

Black Incarcerated Veterans And Va Service Access, Kimona S. Spencer

Dissertations, Theses, and Capstone Projects

This study investigates racial disparities in access to U.S. Department of Veterans Affairs (VA) services among incarcerated Veterans, with a specific focus on Black incarcerated Veterans. Drawing from critical race theory and the minority stress model, the study explores how race, discharge status, military experiences, and mental health conditions intersect to affect potential eligibility for and receipt of VA healthcare and benefits. Utilizing a secondary analysis of data from the Survey of Prison Inmates (SPI), the research employs quantitative methods to examine whether disparities exist in discharge characterizations, potential eligibility for VA care, and service utilization by race. Findings highlight …


Single Mother Poverty In A Global City, Gregory Cala Jun 2025

Single Mother Poverty In A Global City, Gregory Cala

Dissertations, Theses, and Capstone Projects

The thesis explores how New York City's emergence as a "Global City" and welfare reform uniquely impacted single mothers’ lives on the matter of labor, housing, cost of living and more. New York City’s recovery from near bankruptcy in the 1970s began after cutting social programs and luring corporate firms with financial incentives. As firms moved to the city, so did their workforce of employees with skills in specialized service roles. Concurrently, the need for cheap, part-time, and temporary services emerged. By the 1990s, the growth of these less specialized service jobs outpaced all others, all while calls for work …


The Unholy Matrimony: Russia And Violent Non-State Actors, Justin Castro Jun 2025

The Unholy Matrimony: Russia And Violent Non-State Actors, Justin Castro

Dissertations, Theses, and Capstone Projects

Russia’s contemporary relationship with violent non-state actors has been at the forefront of news due to the conflict in Ukraine. Despite the international shock at this phenomenon, this is an age-old practice for Russia. Since the 17th century, the Russian state has developed a strategy of utilizing violent non-state actors in order to achieve its geopolitical objectives that consist of expanding its territory, extending its influence abroad, and weakening the capabilities of adversaries. While this strategy seems clear-cut, it contains a rich history of Russia trying to manage its relationship with non-state actors from a position of weakness and …


Tradwives: The Housewifization Of The Girl Boss, Gagan Kaur Jun 2025

Tradwives: The Housewifization Of The Girl Boss, Gagan Kaur

Dissertations, Theses, and Capstone Projects

This thesis examines the reemergence of a particular performance of domesticity in the post-pandemic era, focusing on the rise of the "tradwife" (traditional wife) movement alongside the normalization and spread of Alt-Right ideology through popular social media platforms. It argues that the tradwife is not a return to tradition, but a commodified performance of domesticity built on the erasure of social reproductive labor. Tracing the lineage of the “housewife” from the enclosure of the commons to imperial domesticity and from the “girl boss” to tradwife influencer culture, this project situates the tradwife within a longer history of "housewifization"—wherein women's labor …


Promises And Pitfalls Of Preimplantation Genetic Testing For Polygenic Disorders: A Narrative Review, Jaime A Roura-Monllor, Zachary Walker, Joel M Reynolds, Greysha Rivera-Cruz, Avner Hershlag, Gheona Altarescu, Sigal Klipstein, Stacey Pereira, Gabriel Lázaro-Muñoz, Shai Carmi, Todd Lencz, Ruth Bunker Lathi Jun 2025

Promises And Pitfalls Of Preimplantation Genetic Testing For Polygenic Disorders: A Narrative Review, Jaime A Roura-Monllor, Zachary Walker, Joel M Reynolds, Greysha Rivera-Cruz, Avner Hershlag, Gheona Altarescu, Sigal Klipstein, Stacey Pereira, Gabriel Lázaro-Muñoz, Shai Carmi, Todd Lencz, Ruth Bunker Lathi

Center for Medical Ethics and Health Policy Staff Publications

Preimplantation genetic testing for polygenic disorders (PGT-P) has been commercially available since 2019. PGT-P makes use of polygenic risk scores for conditions which are multifactorial and are significantly influenced by environmental and lifestyle factors. If current predictions are accurate, then absolute risk reductions range from about 0.02% to 10.1%, meaning that between 10 and 5,000 in vitro fertilization patients would need to be tested with PGT-P to prevent one offspring from becoming affected in the future, depending on the condition and the number of embryos available. Survey and interview data reveal that patients and the public have largely favorable views …


How “Green” Are Green Acquisitions Really?, Sri V Srinivasan Jun 2025

How “Green” Are Green Acquisitions Really?, Sri V Srinivasan

Dissertations and Theses Collection (Open Access)

Our study finds that 43.14% of global green mergers & acquisitions (GMAs) from 2001 to 2020 may be susceptible to Green Embellishment—the gap between corporate environmental representations and actual performance, regardless of intent. Using a multi-criteria theoretical framework, we show that financial constraints strongly drive Green Embellishment in GMAs, with regulatory stringency and national culture moderating this effect. GMAs in weak regulatory environments are especially vulnerable, particularly under high stakeholder pressure. We further provide empirical evidence that financially constrained GMAs with lower green profiles and those in “browner” industries exhibit a higher propensity for Green Embellishment. Even in stringent …


"Change Is All There Is": Exploring Journalistic Coverage Of Gentrification In The St. Johns Neighborhood Of Portland, Or, Eva Kovolitsky Jun 2025

"Change Is All There Is": Exploring Journalistic Coverage Of Gentrification In The St. Johns Neighborhood Of Portland, Or, Eva Kovolitsky

University Honors Theses

Gentrification, as an increasingly significant characteristic of contemporary urban spaces, has been the subject of a vast body of literature. This has prompted further research into how gentrification is described and the implications of language used in both academic research and popular media accounts. This study explores discourse used in journalistic coverage of gentrification in the St. Johns neighborhood of Portland, Oregon. Guided by past work in discourse analysis and critical urban geography, this study attempts to understand how academic discourse on gentrification is both reflected in and divergent from neighborhood-level discourse. This study used data from the St. Johns …


Peak Policy Lab Or Chasing Windmills? The Overlooked Issue Of Misaligned Policy Design, Adam Wellstead, Sarah Giest, Ishani Mukherjee Jun 2025

Peak Policy Lab Or Chasing Windmills? The Overlooked Issue Of Misaligned Policy Design, Adam Wellstead, Sarah Giest, Ishani Mukherjee

Research Collection School of Social Sciences

Policy innovation labs (PILs) are relatively new policy actors and are part of a larger global “labification” movement. They are touted as spaces for the novel development and testing of policy solutions. PILs have evolved into various forms–including those at different levels of government (central, sub-national, and local), sectoral (such as food, transportation, and environment), and cross-sectoral labs (social innovation and data labs). After a decade, some practitioners lament the effectiveness of their efforts and question if policy labs are indeed engines of innovation and change. We argue that the approach to policy design by PILs, in part, is an …


Lessons Learned From Sandboxing, Piloting And Policy Experimentation With Ai And Other Digital Initiatives: Part 1, Summary Report, Steven M. Miller Jun 2025

Lessons Learned From Sandboxing, Piloting And Policy Experimentation With Ai And Other Digital Initiatives: Part 1, Summary Report, Steven M. Miller

Research Collection School Of Computing and Information Systems

This report, "Lessons Learned from Sandboxing, Piloting and Policy Experimentation with AI and Other Digital Initiatives," captures insights and experiences from project experts involved in recent digital innovation initiatives with the governments of Bangladesh, Maldives, and Kazakhstan, and from project experts actively involved with the use of AI for delivering government digital services in the EU, New Zealand, Rwanda, Singapore, United States, and Uzbekistan. The ten in-depth interview write-ups produced from these nine different country settings provide a small but highly informative sample of rich descriptions of some of the important realities, approaches, nuances, issues and challenges related to testing …


The Equal Rights Amendment: The 28th Amendment To The U.S. Constitution, Twiss Butler, Patrick Butler Jun 2025

The Equal Rights Amendment: The 28th Amendment To The U.S. Constitution, Twiss Butler, Patrick Butler

Dignity: A Journal of Analysis of Exploitation and Violence

This article reviews how Supreme Court interpretations of the 14th Amendment have allowed laws to discriminate against women. It aims to show that the Equal Rights Amendment, ratified as the 28th Amendment in 2020, offers a constitutional basis for eliminating all forms of legal sex discrimination against women. These forms include discrimination based on pregnancy and abortion, commodifying women’s bodies, and allowing men to intrude into women’s protected spaces. The review starts with the denial of protection for women by America’s Declaration of Independence in 1776, denounces the Supreme Court’s precedent-setting 1974 Geduldig decision, which ruled—quite illogically—that discrimination …


Lessons Learned From Sandboxing, Piloting And Policy Experimentation With Ai And Other Digital Initiatives: Part 2, Ten In-Depth Interviews, Steven M. Miller Jun 2025

Lessons Learned From Sandboxing, Piloting And Policy Experimentation With Ai And Other Digital Initiatives: Part 2, Ten In-Depth Interviews, Steven M. Miller

Research Collection School Of Computing and Information Systems

This report, "Lessons Learned from Sandboxing, Piloting and Policy Experimentation with AI and Other Digital Initiatives," captures insights and experiences from project experts involved in recent digital innovation initiatives with the governments of Bangladesh, Maldives, and Kazakhstan, and from project experts actively involved with the use of AI for delivering government digital services in the EU, New Zealand, Rwanda, Singapore, United States, and Uzbekistan. The ten in-depth interview write-ups produced from these nine different country settings provide a small but highly informative sample of rich descriptions of some of the important realities, approaches, nuances, issues and challenges related to testing …


Built Environment And Public Electric Vehicle Charging: An Investigation Using Poi Data And Computer Vision, Junfeng Jiao, Seung Jun Choi Jun 2025

Built Environment And Public Electric Vehicle Charging: An Investigation Using Poi Data And Computer Vision, Junfeng Jiao, Seung Jun Choi

Research Collection College of Integrative Studies

Public electric vehicle charging stations (EVCSs) are vital for boosting EV adoption. This study investigates Seoul’s public EV charging patterns, taking into account the surrounding urban built environment. We collected built-environment data from land-use maps, Point of Interest (POI) data, and panorama images near public EVCS. The computer-vision technique was used to extract scene features from panorama images. We conducted a spatiotemporal analysis of public EVCS usage. The built-environment factors underwent dimensionality reduction and were assessed for outliers. Descriptive analysis revealed afternoon peak charging times and variations between chargers. Additional peaks are observed in the weekday late evening for chargers …


A Meta-Analysis Of Diagnostic Yield And Clinical Utility Of Genome And Exome Sequencing In Pediatric Rare And Undiagnosed Genetic Diseases, Rajshree Pandey, Noemi Fluetsch Brennan, Kalliopi Trachana, Sarah Katsandres, Olaf Bodamer, John Belmont, David L Veenstra, Siyang Peng Jun 2025

A Meta-Analysis Of Diagnostic Yield And Clinical Utility Of Genome And Exome Sequencing In Pediatric Rare And Undiagnosed Genetic Diseases, Rajshree Pandey, Noemi Fluetsch Brennan, Kalliopi Trachana, Sarah Katsandres, Olaf Bodamer, John Belmont, David L Veenstra, Siyang Peng

Center for Medical Ethics and Health Policy Staff Publications

Purpose: To systematically evaluate the diagnostic yield and clinical utility of genome sequencing (GS) and exome sequencing (ES; genome-wide sequencing [GWS]) in pediatric patients with rare and undiagnosed genetic diseases.

Methods: We conducted a meta-analysis of studies published between 2011 and 2023. To address study heterogeneity, comparative analyses included within-cohort studies using random-effects models.

Results: We identified 108 studies including 24,631 probands with diverse clinical indications. The pooled diagnostic yield among within-cohort studies (N = 13) for GWS was 34.2% (95% CI: 27.6-41.5; I2: 86%) vs 18.1% (95% CI: 13.1-24.6; I2: 89%) for non-GWS, with 2.4-times odds of diagnosis (95% …


Genome-Wide Analyses Identify 30 Loci Associated With Obsessive-Compulsive Disorder, Nora I Strom, Zachary F Gerring, Marco Galimberti, Dongmei Yu, Matthew W Halvorsen, Abdel Abdellaoui, Cristina Rodriguez-Fontenla, Julia M Sealock, Tim Bigdeli, Jonathan R Coleman, Behrang Mahjani, Jackson G Thorp, Katharina Bey, Christie L Burton, Jurjen J Luykx, Gwyneth Zai, Silvia Alemany, Christine Andre, Kathleen D Askland, Julia Bäckman, Nerisa Banaj, Cristina Barlassina, Judith Becker Nissen, O Joseph Bienvenu, Donald Black, Michael H Bloch, Sigrid Børte, Rosa Bosch, Michael Breen, Brian P Brennan, Helena Brentani, Joseph D Buxbaum, Jonas Bybjerg-Grauholm, Enda M Byrne, Judit Cabana-Dominguez, Beatriz Camarena, Adrian Camarena, Carolina Cappi, Angel Carracedo, Miguel Casas, Maria Cristina Cavallini, Valentina Ciullo, Edwin H Cook, Jesse Crosby, Bernadette A Cullen, Elles J De Schipper, Richard Delorme, Srdjan Djurovic, Jason A Elias, Xavier Estivill, Martha J Falkenstein, Bengt T Fundin, Lauryn Garner, Christina Gironda, Fernando S Goes, Marco A Grados, Jakob Grove, Wei Guo, Jan Haavik, Kristen Hagen, Kelly Harrington, Alexandra Havdahl, Kira D Höffler, Ana G Hounie, Donald Hucks, Christina Hultman, Magdalena Janecka, Eric Jenike, Elinor K Karlsson, Kara Kelley, Julia Klawohn, Janice E Krasnow, Kristi Krebs, Christoph Lange, Nuria Lanzagorta, Daniel Levey, Kerstin Lindblad-Toh, Fabio Macciardi, Brion Maher, Brittany Mathes, Evonne Mcarthur, Nathaniel Mcgregor, Nicole C Mclaughlin, Sandra Meier, Euripedes C Miguel, Maureen Mulhern, Paul S Nestadt, Erika L Nurmi, Kevin S O'Connell, Lisa Osiecki, Olga Therese Ousdal, Teemu Palviainen, Nancy L Pedersen, Fabrizio Piras, Federica Piras, Sriramya Potluri, Raquel Rabionet, Alfredo Ramirez, Scott Rauch, Abraham Reichenberg, Mark A Riddle, Stephan Ripke, Maria C Rosário, Aline S Sampaio, Miriam A Schiele, Anne Heidi Skogholt, Laura G Sloofman, Jan Smit, María Soler Artigas, Laurent F Thomas, Eric Tifft, Homero Vallada, Nathanial Van Kirk, Jeremy Veenstra-Vanderweele, Nienke N Vulink, Christopher P Walker, Ying Wang, Jens R Wendland, Bendik S Winsvold, Yin Yao, Hang Zhou, Estonian Biobank, 23andme Inc, Arpana Agrawal, Pino Alonso, Götz Berberich, Kathleen K Bucholz, Cynthia M Bulik, Danielle Cath, Damiaan Denys, Valsamma Eapen, Howard Edenberg, Peter Falkai, Thomas V Fernandez, Abby J Fyer, J M Gaziano, Dan A Geller, Hans J Grabe, Benjamin D Greenberg, Gregory L Hanna, Ian B Hickie, David M Hougaard, Norbert Kathmann, James Kennedy, Dongbing Lai, Mikael Landén, Stéphanie Le Hellard, Marion Leboyer, Christine Lochner, James T Mccracken, Sarah E Medland, Preben B Mortensen, Benjamin M Neale, Humberto Nicolini, Merete Nordentoft, Michele Pato, Carlos Pato, David L Pauls, John Piacentini, Christopher Pittenger, Danielle Posthuma, Josep Antoni Ramos-Quiroga, Steven A Rasmussen, Margaret A Richter, David R Rosenberg, Stephan Ruhrmann, Jack F Samuels, Sven Sandin, Paul Sandor, Gianfranco Spalletta, Dan J Stein, S Evelyn Stewart, Eric A Storch, Barbara E Stranger, Maurizio Turiel, Thomas Werge, Ole A Andreassen, Anders D Børglum, Susanne Walitza, Kristian Hveem, Bjarne K Hansen, Christian Rück, Nicholas G Martin, Lili Milani, Ole Mors, Ted Reichborn-Kjennerud, Marta Ribasés, Gerd Kvale, David Mataix-Cols, Katharina Domschke, Edna Grünblatt, Michael Wagner, John-Anker Zwart, Gerome Breen, Gerald Nestadt, Jaakko Kaprio, Paul D Arnold, Dorothy E Grice, James A Knowles, Helga Ask, Karin J Verweij, Lea K Davis, Dirk J Smit, James J Crowley, Jeremiah M Scharf, Murray B Stein, Joel Gelernter, Carol A Mathews, Eske M Derks, Manuel Mattheisen Jun 2025

Genome-Wide Analyses Identify 30 Loci Associated With Obsessive-Compulsive Disorder, Nora I Strom, Zachary F Gerring, Marco Galimberti, Dongmei Yu, Matthew W Halvorsen, Abdel Abdellaoui, Cristina Rodriguez-Fontenla, Julia M Sealock, Tim Bigdeli, Jonathan R Coleman, Behrang Mahjani, Jackson G Thorp, Katharina Bey, Christie L Burton, Jurjen J Luykx, Gwyneth Zai, Silvia Alemany, Christine Andre, Kathleen D Askland, Julia Bäckman, Nerisa Banaj, Cristina Barlassina, Judith Becker Nissen, O Joseph Bienvenu, Donald Black, Michael H Bloch, Sigrid Børte, Rosa Bosch, Michael Breen, Brian P Brennan, Helena Brentani, Joseph D Buxbaum, Jonas Bybjerg-Grauholm, Enda M Byrne, Judit Cabana-Dominguez, Beatriz Camarena, Adrian Camarena, Carolina Cappi, Angel Carracedo, Miguel Casas, Maria Cristina Cavallini, Valentina Ciullo, Edwin H Cook, Jesse Crosby, Bernadette A Cullen, Elles J De Schipper, Richard Delorme, Srdjan Djurovic, Jason A Elias, Xavier Estivill, Martha J Falkenstein, Bengt T Fundin, Lauryn Garner, Christina Gironda, Fernando S Goes, Marco A Grados, Jakob Grove, Wei Guo, Jan Haavik, Kristen Hagen, Kelly Harrington, Alexandra Havdahl, Kira D Höffler, Ana G Hounie, Donald Hucks, Christina Hultman, Magdalena Janecka, Eric Jenike, Elinor K Karlsson, Kara Kelley, Julia Klawohn, Janice E Krasnow, Kristi Krebs, Christoph Lange, Nuria Lanzagorta, Daniel Levey, Kerstin Lindblad-Toh, Fabio Macciardi, Brion Maher, Brittany Mathes, Evonne Mcarthur, Nathaniel Mcgregor, Nicole C Mclaughlin, Sandra Meier, Euripedes C Miguel, Maureen Mulhern, Paul S Nestadt, Erika L Nurmi, Kevin S O'Connell, Lisa Osiecki, Olga Therese Ousdal, Teemu Palviainen, Nancy L Pedersen, Fabrizio Piras, Federica Piras, Sriramya Potluri, Raquel Rabionet, Alfredo Ramirez, Scott Rauch, Abraham Reichenberg, Mark A Riddle, Stephan Ripke, Maria C Rosário, Aline S Sampaio, Miriam A Schiele, Anne Heidi Skogholt, Laura G Sloofman, Jan Smit, María Soler Artigas, Laurent F Thomas, Eric Tifft, Homero Vallada, Nathanial Van Kirk, Jeremy Veenstra-Vanderweele, Nienke N Vulink, Christopher P Walker, Ying Wang, Jens R Wendland, Bendik S Winsvold, Yin Yao, Hang Zhou, Estonian Biobank, 23andme Inc, Arpana Agrawal, Pino Alonso, Götz Berberich, Kathleen K Bucholz, Cynthia M Bulik, Danielle Cath, Damiaan Denys, Valsamma Eapen, Howard Edenberg, Peter Falkai, Thomas V Fernandez, Abby J Fyer, J M Gaziano, Dan A Geller, Hans J Grabe, Benjamin D Greenberg, Gregory L Hanna, Ian B Hickie, David M Hougaard, Norbert Kathmann, James Kennedy, Dongbing Lai, Mikael Landén, Stéphanie Le Hellard, Marion Leboyer, Christine Lochner, James T Mccracken, Sarah E Medland, Preben B Mortensen, Benjamin M Neale, Humberto Nicolini, Merete Nordentoft, Michele Pato, Carlos Pato, David L Pauls, John Piacentini, Christopher Pittenger, Danielle Posthuma, Josep Antoni Ramos-Quiroga, Steven A Rasmussen, Margaret A Richter, David R Rosenberg, Stephan Ruhrmann, Jack F Samuels, Sven Sandin, Paul Sandor, Gianfranco Spalletta, Dan J Stein, S Evelyn Stewart, Eric A Storch, Barbara E Stranger, Maurizio Turiel, Thomas Werge, Ole A Andreassen, Anders D Børglum, Susanne Walitza, Kristian Hveem, Bjarne K Hansen, Christian Rück, Nicholas G Martin, Lili Milani, Ole Mors, Ted Reichborn-Kjennerud, Marta Ribasés, Gerd Kvale, David Mataix-Cols, Katharina Domschke, Edna Grünblatt, Michael Wagner, John-Anker Zwart, Gerome Breen, Gerald Nestadt, Jaakko Kaprio, Paul D Arnold, Dorothy E Grice, James A Knowles, Helga Ask, Karin J Verweij, Lea K Davis, Dirk J Smit, James J Crowley, Jeremiah M Scharf, Murray B Stein, Joel Gelernter, Carol A Mathews, Eske M Derks, Manuel Mattheisen

Center for Medical Ethics and Health Policy Staff Publications

Obsessive-compulsive disorder (OCD) affects ~1% of children and adults and is partly caused by genetic factors. We conducted a genome-wide association study (GWAS) meta-analysis combining 53,660 OCD cases and 2,044,417 controls and identified 30 independent genome-wide significant loci. Gene-based approaches identified 249 potential effector genes for OCD, with 25 of these classified as the most likely causal candidates, including WDR6, DALRD3 and CTNND1 and multiple genes in the major histocompatibility complex (MHC) region. We estimated that ~11,500 genetic variants explained 90% of OCD genetic heritability. OCD genetic risk was associated with excitatory neurons in the hippocampus and the cortex, along …


International Society For Cell & Gene Therapy Expanded Access Working Group Position Paper: Key Considerations To Support Equitable And Ethical Expanded Access To Investigational Cell- And Gene-Based Interventions, Elena Maryamchik, Laertis Ikonomou, Beth E Roxland, Felix Grignon, Bruce L Levine, Bambi J Grilley Jun 2025

International Society For Cell & Gene Therapy Expanded Access Working Group Position Paper: Key Considerations To Support Equitable And Ethical Expanded Access To Investigational Cell- And Gene-Based Interventions, Elena Maryamchik, Laertis Ikonomou, Beth E Roxland, Felix Grignon, Bruce L Levine, Bambi J Grilley

Center for Medical Ethics and Health Policy Staff Publications

This position paper reviews the Expanded Access pathway for cell and gene therapies, examining its critical role at the nexus of patient need, regulatory frameworks, and scientific advancement. Spearheaded by the International Society for Cell & Gene Therapy's Expanded Access Working Group, it explores how investigational therapies are accessed outside of clinical trials for patients with serious or life-threatening conditions when no approved alternatives exist. Access to cell and gene therapy products are of specific interest to patients because many times the products are bespoke, being used to treat serious and/or incurable conditions, and are potentially curative. As the field …


Joint Analysis Of The Npod-Virus Group Data: The Association Of Enterovirus With Type 1 Diabetes Is Supported By Multiple Markers Of Infection In Pancreas Tissue, Sarah J Richardson, Teresa Rodriguez-Calvo, Jutta E Laiho, John S Kaddis, Julius O Nyalwidhe, Irina Kusmartseva, Sofia Morfopoulou, Joseph F Petrosino, Vincent Plagnol, Kathrin Maedler, Margaret A Morris, Jerry L Nadler, Mark A Atkinson, Matthias Von Herrath, Richard E Lloyd, Heikki Hyoty, Noel G Morgan, Alberto Pugliese, Npod-Virus Group Jun 2025

Joint Analysis Of The Npod-Virus Group Data: The Association Of Enterovirus With Type 1 Diabetes Is Supported By Multiple Markers Of Infection In Pancreas Tissue, Sarah J Richardson, Teresa Rodriguez-Calvo, Jutta E Laiho, John S Kaddis, Julius O Nyalwidhe, Irina Kusmartseva, Sofia Morfopoulou, Joseph F Petrosino, Vincent Plagnol, Kathrin Maedler, Margaret A Morris, Jerry L Nadler, Mark A Atkinson, Matthias Von Herrath, Richard E Lloyd, Heikki Hyoty, Noel G Morgan, Alberto Pugliese, Npod-Virus Group

Center for Medical Ethics and Health Policy Staff Publications

Aims/hypothesis: Previous pathology studies have associated enterovirus infections with type 1 diabetes by examining the enterovirus capsid protein 1 (VP1) in autopsy pancreases obtained near diabetes diagnosis. The Network for Pancreatic Organ Donors with Diabetes (nPOD) has since obtained pancreases from organ donors with type 1 diabetes (with broad age and disease duration) and donors with disease-associated autoantibodies (AAbs), the latter representing preclinical disease. Two accompanying manuscripts from the nPOD-Virus Group report primary data from a coordinated analysis of multiple enterovirus indices. We aimed to comprehensively assess the association of multiple enterovirus markers with type 1 diabetes.

Methods: The nPOD-Virus …


Detection Of Enterovirus Rna In Pancreas And Lymphoid Tissues Of Organ Donors With Type 1 Diabetes, Jutta E Laiho, Sami Oikarinen, Sofia Morfopoulou, Maarit Oikarinen, Ashlie Renner, Daniel Depledge, Matthew C Ross, Ivan C Gerling, Judith Breuer, Joseph F Petrosino, Vincent Plagnol, Alberto Pugliese, Antonio Toniolo, Richard E Lloyd, Heikki Hyöty, Npod-Virus Group Jun 2025

Detection Of Enterovirus Rna In Pancreas And Lymphoid Tissues Of Organ Donors With Type 1 Diabetes, Jutta E Laiho, Sami Oikarinen, Sofia Morfopoulou, Maarit Oikarinen, Ashlie Renner, Daniel Depledge, Matthew C Ross, Ivan C Gerling, Judith Breuer, Joseph F Petrosino, Vincent Plagnol, Alberto Pugliese, Antonio Toniolo, Richard E Lloyd, Heikki Hyöty, Npod-Virus Group

Center for Medical Ethics and Health Policy Staff Publications

Aims/hypothesis: The nPOD-Virus group collaboratively applied innovative technologies to detect and sequence viral RNA in pancreas and other tissues from organ donors with type 1 diabetes. These analyses involved the largest number of pancreas samples collected to date. The aim of the current work was to examine the presence of enterovirus RNA in pancreas and lymphoid tissues of organ donors with and without type 1 diabetes.

Methods: We analysed pancreas, spleen, pancreatic lymph nodes and duodenum samples from the following groups: (1) donors with type 1 diabetes (n=71) with (n=35) or without (n=36) insulin-containing islets; (2) donors with single or …


A Multi-Site Study Of Clinician Perspectives In The Lifecycle Of An Algorithmic Risk Prediction Tool, Rita Dexter, Kristin Kostick-Quenet, Jennifer Blumenthal-Barby Jun 2025

A Multi-Site Study Of Clinician Perspectives In The Lifecycle Of An Algorithmic Risk Prediction Tool, Rita Dexter, Kristin Kostick-Quenet, Jennifer Blumenthal-Barby

Center for Medical Ethics and Health Policy Staff Publications

Recent advancements in the performative capacities of artificial intelligence (AI), machine learning (ML), and algorithmic-based tools open up numerous applications in modern medicine. There are, however, few studies that track the whole lifecycle of a digital healthcare tool as it evolves from conception, to design, and deployment in real world settings-especially with a focus on the social dynamics amongst the end-users of the tool: clinicians. In this paper, we present data from a multi-site, 5-year study focused on the development and deployment of an algorithmic risk calculator (HeartMate 3 Risk Score) into a validated and efficacy tested clinical decision support …


Not Meant To Be Read: The Stories They Silence, The Resistance That Speaks, Cristina Onea Jun 2025

Not Meant To Be Read: The Stories They Silence, The Resistance That Speaks, Cristina Onea

Dissertations, Theses, and Capstone Projects

In this dissertation, I trace the evolution of surveillance from overt state violence to the more insidious forms of ideological policing embedded in everyday life. Through lived experience, oral history, and critical autoethnography, I explore how surveillance moves through bodies, families, institutions, and memory—not simply as external control, but as internalized rhythms of fear, vigilance, and self-surveillance. I move between my father's life under Romanian dictatorship, my own embodied inheritance, and the contemporary struggles of librarians facing ideological suppression to reveal surveillance as a structure that persists through generations, mutates across contexts, and demands new forms of resistance.

I argue …


Comparing Campaigns To End The Subminimum Wage With A Multiple Streams Approach, Chris Peraino Jun 2025

Comparing Campaigns To End The Subminimum Wage With A Multiple Streams Approach, Chris Peraino

Dissertations, Theses, and Capstone Projects

Labor organizations do not significantly represent the interests of restaurant workers in the United States. In the absence of labor representation, nonprofits have become the main advocates for restaurant workers in politics. Among the most active is OneFairWage (OFW), a nonprofit focused on eliminating the subminimum wage for tipped restaurant workers. OFW’s legislative efforts have had mixed outcomes. Two of its campaigns - D.C. and Chicago - were successful. All other campaigns, like those in New York state and Michigan, have struggled to achieve their goal. Why has nearly identical legislation with the same target population of restaurant workers passed …


Moving The Needle: The Policy Of Change On Syringe Access, New York City And State, 1988–2023, Joyce Rivera Jun 2025

Moving The Needle: The Policy Of Change On Syringe Access, New York City And State, 1988–2023, Joyce Rivera

Dissertations, Theses, and Capstone Projects

By the mid-1980s, the HIV/AIDS epidemic breached a longstanding consensus between the political class and its bureaucratic alliances that had relied for decades on attitudes and orientations that championed punitive prohibition toward drugs as a bedrock principle of policy making. This ‘focusing event’ created an opening for HIV/AIDS activists to build a movement that offered an alternative, a more effective and just approach to how government policies and practices can manage illegal drugs and the persons who use drugs.

The dissertation uses several theoretical and methodological tools to address the central research objective that highlights the critical role played by …


Path Dependency And The Politics Of U.S. Health Reform, Sophia Spadafore Jun 2025

Path Dependency And The Politics Of U.S. Health Reform, Sophia Spadafore

Dissertations, Theses, and Capstone Projects

This study examines the impact of path dependency on health reform efforts in the United States, specifically analyzing how past policy decisions constrain subsequent reform possibilities. Utilizing the theoretical framework of historical institutionalism, the study investigates two significant cases—the passage of Medicare and Medicaid in 1965 and the The Patient Protection and Affordable Care Act (ACA) in 2010—to illustrate how successful healthcare reforms embed institutional arrangements that limit future policy innovation. Through a comparative case study approach grounded in legislative records, historical texts, and scholarly analyses, the research highlights that major healthcare reforms in the U.S. have consistently been structured …


Faith In Conflict: The Role Of Religion In Conflict And Peacebuilding Among Minority Christian Communities In Ukraine And Palestine, Julia Lats May 2025

Faith In Conflict: The Role Of Religion In Conflict And Peacebuilding Among Minority Christian Communities In Ukraine And Palestine, Julia Lats

Honors Projects

Religion has long influenced both the escalation of conflicts and efforts toward peace. The wars in Ukraine and Palestine are deeply rooted in historical narratives, national identities, and religious influences. While the Israeli-Palestinian conflict is often framed in terms of Jewish-Muslim tensions and the issue of politicization of religion and tensions within the Orthodox Church frame the Ukrainian-Russian War, these dominant narratives often overlook the role of minority religious groups. This paper examines the contributions of Protestant Christian groups in these regions, exploring how their beliefs and practices influence their actions, identity formation, interactions with others, and approaches to conflict …


Do Myths Ever Die? Social-Cultural Changes And Mythical Transformations In Indigenous Amazonia: A Dialogue With Peter Gow, Aparecida M. N. Vilaça May 2025

Do Myths Ever Die? Social-Cultural Changes And Mythical Transformations In Indigenous Amazonia: A Dialogue With Peter Gow, Aparecida M. N. Vilaça

Tipití: Journal of the Society for the Anthropology of Lowland South America

This is the first Peter Gow Memorial Lecture, given at the University of St Andrews in February 2024. Based on the analysis of different versions of Wari’ myths (Rondônia, Brazil) collected over forty years, the paper has two central objectives. The first is to engage with Peter Gow’s analysis of the mythical transformations resulting from the historical changes experienced by the Piro/Yine Indigenous people of Peru. The second is to discuss Lévi-Strauss’s suggestion that a myth can “die” after successive transformations, exhausting itself, taking the form of romantic tale or legendary tradition.


An X-Ray Of Mẽbêngôkre Houses In Terms Of Matrimonial Alliance, Vanessa R. Lea, Leandro Mahalem De Lima May 2025

An X-Ray Of Mẽbêngôkre Houses In Terms Of Matrimonial Alliance, Vanessa R. Lea, Leandro Mahalem De Lima

Tipití: Journal of the Society for the Anthropology of Lowland South America

This article examines the matrimonial implications of the Houses, or matrihouses, of the Mẽtyktire subgroup of the Mẽbêngôkre (Kayapó-Jê) with the assistance of Puck (Program for the Use and Computation of Kinship Data) and Pajek software. In accordance with the greater legibility of graphics, statistical results have been converted into graphics whenever possible. The analysis is based on a revised version of a dataset spanning the years 1978 to 1982 and published on the site Kinsources. What began as a village census later morphed into genealogies, which served as the basis for the digital dataset. The matrihouses …


Home Values Vs. Homelessness In Mountain West Metros, 2023, Maryam Raja, Caitlin J. Saladino, William E. Brown Jr. May 2025

Home Values Vs. Homelessness In Mountain West Metros, 2023, Maryam Raja, Caitlin J. Saladino, William E. Brown Jr.

Housing & Real Estate

This fact sheet presents data from Home Values vs. Homelessness in the U.S.: A Concerning Connection (2023 Data), a report by Home Bay. The data includes information on both home values and homelessness rates while also providing national rankings for rent price and homeless rate, which are used here to compare the following Mountain West metros: Las Vegas, NV; Denver, CO; Salt Lake City, UT; and Phoenix, AZ.


Bridging The Divide: Gaps In Mental Health Resources For K-12 Students In Nevada, Nicole Diaz Del Valle May 2025

Bridging The Divide: Gaps In Mental Health Resources For K-12 Students In Nevada, Nicole Diaz Del Valle

Student Research

Since 2014, Nevada has consistently ranked among the bottom five states, if not last, in the nation for youth mental health, with more than 34,000 youth reporting experiencing thoughts of suicide in 2025 (U.S. Department of Health and Human Services, 2023). The state’s student-to-counselor ratio stands at 456 to 1, nearly double the recommended 250 to 1 (American School Counselor Association, 2024). In Southern Nevada, these challenges are compounded with persistent provider shortages, chronic underfunding, and a fragmented system of care. This policy brief focuses on the barriers preventing students from receiving timely, effective mental health support in school settings …


Sed Waiver Seclusion And Restraint Data, Genevieve Graaf, Alex Fejer, Monica Canizares May 2025

Sed Waiver Seclusion And Restraint Data, Genevieve Graaf, Alex Fejer, Monica Canizares

Social Work Datasets-Archive

This dataset includes a set of policy indicators about what states do and do not allow, and what types of oversight and safeguards they provide, around the use of seclusion, restraint and other restrictive interventions in 1915(c) Medicaid home and community based services waiver programs for children with significant mental health needs. Includes data for all states operating these programs from 2008 to 2024.


Reimagining Military-To-Civilian Transition: Addressing Barriers And Building Solutions, Rosalinda V. Maury, Gilly Cantor, Jeanette Harvie May 2025

Reimagining Military-To-Civilian Transition: Addressing Barriers And Building Solutions, Rosalinda V. Maury, Gilly Cantor, Jeanette Harvie

Institute for Veterans and Military Families

This brief highlights key findings from IVMF research, outlines IVMF policy priorities, showcases the impact of Onward to Opportunity (O2O), and emphasizes the importance of stronger collaboration across public, private, nonprofit, and education sectors. Our goal is to inform decision-making and drive actionable solutions that reduce barriers to successful transition, improve long-term stability, and create meaningful career pathways for those who have served.