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Accept Yourself! A Pilot Randomized Controlled Trial Of A Self-Acceptance-Based Treatment For Large-Bodied Women With Depression, Margit Berman, John Park, Monica E. Kragenbrink, Mark T. Hegel Sep 2022

Accept Yourself! A Pilot Randomized Controlled Trial Of A Self-Acceptance-Based Treatment For Large-Bodied Women With Depression, Margit Berman, John Park, Monica E. Kragenbrink, Mark T. Hegel

Faculty Authored Articles

A pilot parallel randomized controlled trial compared a self-acceptance, non-weight-loss intervention, Accept Yourself! (AY), to a weight loss program, Weight Watchers (WW), in order to provide preliminary safety, feasibility, and efficacy data in preparation for a definitive RCT of AY as an intervention to enhance the mental and physical health of larger-bodied women with Major Depressive Disorder(MDD). Adult women with MDD and a Body Mass Index ≥30 were eligible. Nineteen women were randomized by random number table into AY (n = 9) or WW (n = 10). Intake, pretreatment, posttreatment, 3-, 6-, 9-, and 12-month follow-up assessments occurred …


Moving Toward, Moving Against, And Moving Away: An Interpersonal Approach To Construct Validation Of The Horney–Coolidge Type Inventory, Steven E. Carlson, Timothy W. Smith, Kimberly A. Parkhurst, Ruben Tinajero, Jeremy L. Grove, Christian Goans, Michiyo Hirai, John M. Ruiz Sep 2022

Moving Toward, Moving Against, And Moving Away: An Interpersonal Approach To Construct Validation Of The Horney–Coolidge Type Inventory, Steven E. Carlson, Timothy W. Smith, Kimberly A. Parkhurst, Ruben Tinajero, Jeremy L. Grove, Christian Goans, Michiyo Hirai, John M. Ruiz

Psychological Science Faculty Publications

Karen Horney’s interpersonal theory of adjustment defined three different neurotic trends involving characteristic social behavior and motives: compliant (moving toward people), aggressive (moving against people), and detached (moving away from people). The Horney–Coolidge Type Inventory (HCTI) was developed to assess these trends, but has not been validated using standard methods in the interpersonal perspective. The studies reported here refined the structure of the HCTI, and utilized the structural summary method (SSM) to identify relationships of the three shortened HCTI trend scales with the interpersonal circumplex (IPC) in single university (n = 514) and multisite university (n = 3,283) …


Belonging Amidst Bias: Embracing Difference On The Path To Common Humanity, Alyssia Sheikh Sep 2022

Belonging Amidst Bias: Embracing Difference On The Path To Common Humanity, Alyssia Sheikh

Mindfulness Studies Theses

The mindfulness community prioritizes self-awareness and common humanity, but is often entrapped by the idea that oneness is equivalent to sameness. This inclination for objectivity is rooted in the same neural propensities that facilitate bias; the brain is a subjective organ, however, and so neurologically speaking, bias is inevitable. This paper asks: Is striving for sameness separating us from interconnectedness? A human experience is a subjective, diverse, and variable one. The path to shared humanity and social justice co-occurs with increasing cultural humility through mindful awareness and acknowledging our subjective nature. Exploring our neurological tendency to make assumptions, we …


Taming The Wandering Mind: Where Buddhism & Polyvagal Theory Meet, Tamara Embrey Sep 2022

Taming The Wandering Mind: Where Buddhism & Polyvagal Theory Meet, Tamara Embrey

Mindfulness Studies Theses

The ability to tame the wandering mind is at the heart of the insights emerging from the places where Buddhism and the Polyvagal Theory (Porges, 2001, 2011) meet. A polyvagal understanding of how our nervous system functions opens the door to developing skills that can strengthen our ability to regulate ourselves and others during times of challenge. The Buddha’s meditation instructions, laid out in the Satipaṭṭhāna Sutta, the Establishment of Mindfulness Discourse offers a type of attentional training that allows us to become aware of our current neural state so that we can make intentional choices to tame our wandering …


The Cooperation Databank: Machine-Readable Science Accelerates Research Synthesis, Giuliana Spadaro, Ilaria Tiddi, Simon Columbus, Shuxian Jin, Adam W. Stivers Sep 2022

The Cooperation Databank: Machine-Readable Science Accelerates Research Synthesis, Giuliana Spadaro, Ilaria Tiddi, Simon Columbus, Shuxian Jin, Adam W. Stivers

Psychology Faculty Scholarship

Publishing studies using standardized, machine-readable formats will enable machines to perform meta-analyses on demand. To build a semantically enhanced technology that embodies these functions, we developed the Cooperation Databank (CoDa)—a databank that contains 2,636 studies on human cooperation (1958–2017) conducted in 78 societies involving 356,283 participants. Experts annotated these studies along 312 variables, including the quantitative results (13,959 effects). We designed an ontology that defines and relates concepts in cooperation research and that can represent the relationships between results of correlational and experimental studies. We have created a research platform that, given the data set, enables users to retrieve studies …


Ssri-Induced Emotional Blunting: A Study Of Cognitive Changes In Pharmaceutically Treated Depression, Carly Tocco Sep 2022

Ssri-Induced Emotional Blunting: A Study Of Cognitive Changes In Pharmaceutically Treated Depression, Carly Tocco

Dissertations, Theses, and Capstone Projects

Objective: In recent years, approximately 12.7% of the American population are on a prescribed antidepressant medication. Selective Serotonin Reuptake Inhibitors (SSRIs) are a widely used pharmacological treatment for depressive and anxiety disorders, primarily due to their tolerance levels, mild side effects in comparison to other antidepressants, and broad range of clinical indications. However, there are still numerous concerns about SSRIs’ ability to improve depressive symptoms without adding side effects such as sexual dysfunction, gastrointestinal upset, and a restricted range of emotions. Although patients typically claim that they have less emotional pain while on SSRIs than they do during a depressive …


An Interdisciplinary Approach To The Epistemic Value Of Moral Ambiguity, Jordan Wylie Sep 2022

An Interdisciplinary Approach To The Epistemic Value Of Moral Ambiguity, Jordan Wylie

Dissertations, Theses, and Capstone Projects

Morality is a critical aspect of life––it influences how we think, design political and legal systems, who we connect with, our norms, and the types of stories we tell. Yet, even with the well documented influence of morality on many aspects of life, exactly what makes moral themes so fascinating remains elusive. This dissertation aims to introduce Moral Worldbuilding as a theory for understanding our epistemic drives toward morally ambiguous and morally bad content.

In Chapter I, we introduce the problem of moral badness, which is not well handled by extant moral literature. To combat this, we offer a new …


Neuroanatomy In Mild Cognitive Impairment: Relationship To Functional Skills, Treatment Expectancy, And Comorbid Depression, Sara Rushia Sep 2022

Neuroanatomy In Mild Cognitive Impairment: Relationship To Functional Skills, Treatment Expectancy, And Comorbid Depression, Sara Rushia

Dissertations, Theses, and Capstone Projects

Mild cognitive impairment (MCI) is a neurocognitive disorder defined by cognitive decline in older adults. Although MCI has been studied for decades, there remain important areas to be explored in order to adequately characterize aspects of this disorder that provide information valuable for possible interventions and disease progression to dementia, including a better understanding of the neuroanatomical variables relevant to this disorder. Such neuroanatomical variables include cortical thickness, hippocampal volume, and white matter hyperintensities (WMHs). This dissertation consists of three separate studies aimed at addressing gaps in the literature on MCI in relation to brain morphometrics and under-studied characteristics involved …


Linguistic Abstractions In Children’S Very Early Utterances, Qihui Xu Sep 2022

Linguistic Abstractions In Children’S Very Early Utterances, Qihui Xu

Dissertations, Theses, and Capstone Projects

How early do children produce multiword utterances? Do children's early utterances reflect abstract syntactic knowledge or are they the result of data-driven learning? We examine this issue through corpus analysis, computational modeling, and adult simulation experiments. Chapter 1 investigates when children start producing multiword utterances; we use corpora to establish the development of multiword utterances and a probabilistic computational model to account for the quantitative change of early multiword utterances. We find that multiword utterances of different lengths appear early in acquisition and increase together, and the length growth pattern can be viewed as a probabilistic and dynamic process.

Chapter …


Three Lenses Of Contrapower Sexual Harassment, Michael L. Ekema Sep 2022

Three Lenses Of Contrapower Sexual Harassment, Michael L. Ekema

Dissertations, Theses, and Capstone Projects

Contrapower sexual harassment refers to sexual harassment incidents where the perpetrator has less formal power within the organization than the person being victimized. Although the potential for inverse power dynamics were already identified in the early stages of sexual harassment research, the prevalence and antecedents of contrapower sexual harassment have rarely been examined. In addition, prior sexual harassment research has overwhelmingly prioritized gender as the focal variable of interest. This dissertation seeks to contribute to the literature on workplace incivility, organizational deviance, and counterproductive work behaviors by looking at contrapower harassment through three different lenses: The perspective of harassment targets, …


Coercive Control And Trauma-Coerced Attachment In Commercial Sexual Exploitation: A Mixed-Method Examination, Kendra Doychak Sep 2022

Coercive Control And Trauma-Coerced Attachment In Commercial Sexual Exploitation: A Mixed-Method Examination, Kendra Doychak

Dissertations, Theses, and Capstone Projects

Commercial sexual exploitation (i.e., sex trafficking) can lead to myriad negative consequences for its victims, including exposure to coercive control and the development of trauma-coerced attachments. Scholars have offered theoretical conceptualizations of the relation between coercive environments and traumatic attachments, but this relationship is rarely empirically examined. The current study used data from 68 semi-structured interviews with former victims of sex trafficking to first, formally identify coercive control and second, empirically classify trauma-coerced attachment in this population. Mixed-method analysis were used to identify associations between coercive control and TCA in order to better explain how this abuse dynamic leads to …


A Pilot Feasibility Trial Of Mindfulness And Modification Therapy For Males Who Use Aggression, Jenny Mitchell Sep 2022

A Pilot Feasibility Trial Of Mindfulness And Modification Therapy For Males Who Use Aggression, Jenny Mitchell

Dissertations, Theses, and Capstone Projects

Physical aggression incurs substantial harm to victims and witnesses, particularly when it occurs within close relationships such as family, friendships, or intimate partnerships. Men who use aggression against partners and other adults frequently experience high levels of psychopathology, including depression, posttraumatic stress symptoms, anxious/insecure attachment, paranoia, bipolar disorder, intermittent explosive disorder, personality disorders, and substance abuse, which contribute to use of aggressive behaviors. However, existing treatments for aggression often do not address these symptoms. It is important that treatments for aggression are grounded in theoretical literature and backed by empirical support in order to increase treatment engagement and effectiveness. Treatments …


Fathers Are Fathers Are Fathers: How Sociocultural Context And Sexual Orientation Influence The Gendering Of Children, Sarah M. Frantz Sep 2022

Fathers Are Fathers Are Fathers: How Sociocultural Context And Sexual Orientation Influence The Gendering Of Children, Sarah M. Frantz

Dissertations, Theses, and Capstone Projects

Though the body of literature on gay father-headed families indicates there is no significant differences on measures of gender normativity and well-being between children raised with two dads and their peers raised by heterosexual parents, there is a proliferation of anti-LGBTQ+ policies throughout the United States aimed at limiting this community’s rights and silencing their lived experiences. Given that sociocultural and political environments vary greatly state-to-state, it is important to see how the specific context in which fathers live may impact their differential parenting of sons and daughters, their gender beliefs, and the way they feel they would navigate gender …


Antisocial Behavior And Callous Unemotional Traits In Youth: A Biosocial Approach, Yong Lin Huang Sep 2022

Antisocial Behavior And Callous Unemotional Traits In Youth: A Biosocial Approach, Yong Lin Huang

Dissertations, Theses, and Capstone Projects

Early life presence of antisocial behavior (e.g., aggression/delinquency) and psychopathic/callous-unemotional (CU) traits (lacking empathy/remorse, shallow affect) are precursors to juvenile crime and criminal offending in adulthood. Etiological research on antisocial/CU tendencies has implicated both neurobiological (e.g., alterations in brain function and structure) and environmental (social adversity, prenatal stress) underpinnings. It has been proposed that reward and punishment processing deficits may induce problematic traits and behavior, such that antisocial/CU tendencies may be linked to hypersensitivity to rewards and hyposensitivity to punishment. Studies in this area have generated inconsistent findings and focused primarily on adult and clinical samples, leaving youth and community …


The Social Construction Of Premenstrual Dysphoric Disorder (Pmdd), Raya Balabanova Sep 2022

The Social Construction Of Premenstrual Dysphoric Disorder (Pmdd), Raya Balabanova

Dissertations, Theses, and Capstone Projects

The creation of psychiatric diagnoses, otherwise known as psychiatric nosology, is a complex endeavor, one involving a great deal of social construction. One diagnosis in particular, premenstrual dysphoric disorder (PMDD), exemplifies the different factors that go into the creation of psychiatric labels. After decades of research, activism, and debates, PMDD was included in the diagnostic and statistical manual (DSM-5), which is widely used by clinicians in the U.S. This thesis aims to describe how the symptoms described by PMDD caught the attention of the medical profession and how PMDD was shaped into the diagnosis it is today. The introduction of …


A Survey Study Of Speech-Language Therapists’ Experiences With Teletherapy At The Onset Of The Covid-19 Crisis, Jason A. Rosas Sep 2022

A Survey Study Of Speech-Language Therapists’ Experiences With Teletherapy At The Onset Of The Covid-19 Crisis, Jason A. Rosas

Dissertations, Theses, and Capstone Projects

The present study aimed to understand how delivering pediatric treatment services via ‘teletherapy’ affected speech-language therapists (SLTs) during the initial outbreak of the COVID-19 pandemic crisis in 2020. SLTs reported on their experiences with the change from in-person to remote service delivery via two national surveys distributed at the start of the pandemic between April 2020 and July 2020. To explain SLTs’ survey responses, this dissertation introduced the Professional Adaptation Model (PA Model). The PA Model facilitated evaluation of the SLTs’ professional environment and the psychological constructs of their professional identity believed to influence the transition to speech-language teletherapy. Specifically, …


Dietary Approaches To The Treatment Of Autism Spectrum Disorders, Dhira Patel Sep 2022

Dietary Approaches To The Treatment Of Autism Spectrum Disorders, Dhira Patel

Loma Linda University Electronic Theses, Dissertations & Projects

This chapter reviews the literature surrounding autism spectrum disorders (ASD) and their relation to gastrointestinal (GI), behavioral, neurological, and immunological functioning. Individuals with ASDs often have poor GI health, including bowel motility issues, autoimmune and/or other adverse responses to certain foods, and lack of necessary nutrient absorption. These issues may be caused or exacerbated by restrictive behavioral patterns (e.g., preference for sweet and salty foods and/or refusal of healthy foods). Those individuals with GI issues tend to demonstrate more behavioral deficits (e.g., irritability, agitation, hyperactivity) and also tend to have an imbalance in overall gut microbiome composition, thus corroborating several …


Crm As A Psychosocial Intervention For Cancer Patients, Lauren Wakabayashi Sep 2022

Crm As A Psychosocial Intervention For Cancer Patients, Lauren Wakabayashi

Loma Linda University Electronic Theses, Dissertations & Projects

The present treatment manual is intended to outline the implementation of an intervention to manage psychological distress in cancer patients. Cancer patients suffer from psychological distress, in part due to physical symptoms that impact well-being. This can create a cycle of poor mental and physical health that is bidirectionally affected by poor responses to physical treatments. Thus, it is necessary to implement interventions for cancer patients that can combat these and other psychological symptoms. The Community Resiliency Model (CRM) has recently emerged as a set of wellness skills that can promote physiological and psychological well-being, as well as minimize negative …


Insufficient Sleep And Onset Of Coronary Artery Disease, Pooja S. Raghani Sep 2022

Insufficient Sleep And Onset Of Coronary Artery Disease, Pooja S. Raghani

Loma Linda University Electronic Theses, Dissertations & Projects

Coronary artery disease (CAD), a consequence of coronary atherosclerosis, is the most common form of cardiovascular disease. Recent research suggests that compared to individuals with normal sleep duration, those with insufficient sleep, defined as short sleep duration (i.e., less than 6 hours per 24-hour period) have a 79% higher risk of developing coronary artery disease. In this review, selected physiological factors (including vascular inflammation, sympathetic overactivity, and increases in blood pressure), behavioral factors (including sedentary behavior and dietary choices), psychological factors (including hostility, fatigue, and major depressive disorder/depressive affect), and sociocultural factors (including race/ethnicity, socioeconomic status, and health literacy) were …


Community Resiliency Model Treatment Manual For Loma Linda University Healthcare, Ann White Sep 2022

Community Resiliency Model Treatment Manual For Loma Linda University Healthcare, Ann White

Loma Linda University Electronic Theses, Dissertations & Projects

Burnout is a national phenomenon on the United States, effecting between 60% and 78% of healthcare professionals (21) across a variety of settings. Burnout results in increased cost to the healthcare industry, significantly decreased quality of patient care, and increased malpractice claims. At the same time, healthcare providers are increasingly under demands to their time that limit their ability to access wellness resources to mitigate the effects of burnout, such as outpatient psychotherapy. In order to address this growing crisis and respond to the specific needs of healthcare providers, we have utilized the biological basis and six skills comprising the …


Dsm-5 Eating Disorders And Disordered Eating Behaviors In The Lgbt Population, Lacie Parker Sep 2022

Dsm-5 Eating Disorders And Disordered Eating Behaviors In The Lgbt Population, Lacie Parker

Loma Linda University Electronic Theses, Dissertations & Projects

According to Meyer’s sexual minority stress model (2003), LGB individuals experience a higher prevalence of psychopathology, which is attributable to the increased stress (i.e., stigma and prejudice) adult sexual minority individuals experience. This model was later adapted by Hendricks and Testa (2012) to include transgender and gender non-conforming individuals. More specifically, this literature review examined the empirical literature regarding the rates and types of, and risk and protective factors for eating disorders and disordered eating behaviors in the general LGBT adolescent and adult populations, in addition to each individual subgroup (i.e., lesbians, gay men, bisexuals, transgender individuals). The results of …


Dietary Fatty Acids And The Brain: Mechanisms Behind Neurodegeneration And Neuroprotection, Bianca Kdeiss Sep 2022

Dietary Fatty Acids And The Brain: Mechanisms Behind Neurodegeneration And Neuroprotection, Bianca Kdeiss

Loma Linda University Electronic Theses, Dissertations & Projects

The impact of dietary fat intake on cognitive function has generated growing interest as the incidence of neurodegenerative disorders continues to increase. No known cures for neurodegenerative disorders exist at this time and available pharmacological treatments are limited in their efficacy. As such, prevention and early detection have been emphasized, particularly in the context of modifiable lifestyle factors, such as diet. Despite a recognized association between dietary fat intake and cognition, limited research exists delineating the impact of different types of fat on cognitive function. In this review, research examining the association between cognition and specific dietary fatty acids—such as …


The Community Resiliency Model In Health Decision-Making, Michelle Ngo Sep 2022

The Community Resiliency Model In Health Decision-Making, Michelle Ngo

Loma Linda University Electronic Theses, Dissertations & Projects

This doctoral project reviews the literature to support the utilization of the Community Resilience Model (CRM) for health-related decision making, such as health behavior change and medication adherence. Research has shown that decision-making under significant stress can lead to making less advantageous choices, as the nervous system becomes dysregulated. The evidence in this literature review suggests that self-regulation using skills in the CRM Model can increase one’s ability to effectively making decisions.


Parent Treatment Manual For Adolescent Self-Harm, Miriam Mokhless Rizk Sep 2022

Parent Treatment Manual For Adolescent Self-Harm, Miriam Mokhless Rizk

Loma Linda University Electronic Theses, Dissertations & Projects

This doctoral project is a treatment manual that was created for parents of self-harming adolescents. To date, no treatment manual currently exists to aide these parents in fostering healthy environments for adolescents completing Dialectical Behavioral Therapy (DBT) intensive outpatient treatments; however, the literature describes the importance of creating validating environments as an important factor in positive treatment outcomes of adolescents who self-harm. This ten-week treatment manual was designed to provide these parents with DBT skills in order to learn the foundations of providing a positive environment in the home. The results of this treatment manual are projected to reduce parenting …


Cerebrovascular Impairment As A Potential Target For Neuromodulation Therapy In Moderate-Severe Traumatic Brain Injury, Naomi L. Gaggi Sep 2022

Cerebrovascular Impairment As A Potential Target For Neuromodulation Therapy In Moderate-Severe Traumatic Brain Injury, Naomi L. Gaggi

Dissertations, Theses, and Capstone Projects

The main purpose of this dissertation is to characterize noninvasive neuroimaging biomarkers of neurovascular injury in moderate-severe traumatic brain injury (msTBI) as potential treatment targets for neuromodulation therapy. In Chapter 1, I aim to introduce msTBI and two known sequelae of neurovascular damage in msTBI: reduced cerebral blood flow (Ware et al., 2020; Julliene et al., 2016) and altered low frequency fluctuations in blood oxygen level-dependent signal (Zhou et al., 2021; Palacios et al., 2013). Chapter 2 aims to identify the regional pattern of altered resting cerebral blood flow from a cohort of 29 patients with msTBI assessed at 3, …


Relationships Between Sensory Reactivity, Restricted And Repetitive Behaviors, And Autonomic Nervous System Activity In Autistic And Non-Autistic Individuals, Sapir Elimaliah Sep 2022

Relationships Between Sensory Reactivity, Restricted And Repetitive Behaviors, And Autonomic Nervous System Activity In Autistic And Non-Autistic Individuals, Sapir Elimaliah

Dissertations, Theses, and Capstone Projects

The current dissertation includes seven chapters. Chapter 1 includes my professional background and describes the experiences that led me to study restricted and repetitive behaviors. It also briefly describes my personal journey as an international graduate student. Chapter 2 is devoted to the rich literature that this dissertation is based on. The literature review covers both the foundational and most recent findings in the fields of sensory reactivity, restricted and repetitive behaviors, and autonomic activity, as well as the known relationships between these areas in autistic and non-autistic individuals. In Chapter 3, I describe in detail the methodology used in …


Oxytocin, A Lover And A Fighter: Maternal Trauma Exposure And Mother-Child Coregulation, Patricia M. Pehme Sep 2022

Oxytocin, A Lover And A Fighter: Maternal Trauma Exposure And Mother-Child Coregulation, Patricia M. Pehme

Dissertations, Theses, and Capstone Projects

The placenta is responsible for regulating the fetal growth and environment in preparation for the anticipated external life. To succeed, it continuously adapts and weaves in a variety of neuroendocrine signals from the maternal organism. If a mother was exposed to trauma and her physiology sustained a change in the functioning of the immune, autonomic and/or endocrine systems, the placenta may anticipate different external environments for her children as compared to children of mothers without trauma exposure. This dissertation examined possible underlying mechanisms of psychosocial trauma transmission from one generation to the next via the placental oxytocinergic pathway. Encompassing three …


Investigating Young Adult Cancer Survivors' Perspectives On Their Future And Interpersonal Relationships, Zeba N. Ahmad Sep 2022

Investigating Young Adult Cancer Survivors' Perspectives On Their Future And Interpersonal Relationships, Zeba N. Ahmad

Dissertations, Theses, and Capstone Projects

For many young adults (YA, aged 18-39) who have recently survived cancer, planning and working towards goals for the future is a fraught process. Prior research consistently identifies the challenges of survivorship, including: rebuilding personal identity, accepting the impact of cancer-related interruptions on personal goals, navigating new roles in significant close relationships, and initiating new relationships as a survivor. However, there is limited research describing the mechanisms underlying these persistent challenges, which poses difficulties when tailoring evidence-based psychological intervention. The present study consolidates both established and newly hypothesized survivorship challenges into a novel conceptual model, hypothesizing that they are interrelated, …


The Impossible Situation? Impasse As Psychotherapeutic Paralysis, Possibility, And Progress, Leo Cancelmo Sep 2022

The Impossible Situation? Impasse As Psychotherapeutic Paralysis, Possibility, And Progress, Leo Cancelmo

Dissertations, Theses, and Capstone Projects

Psychotherapeutic impasse has long been understood in the clinical literature as treatment stagnation and even failure, both from one-person and two-person psychodynamic perspectives. However, there is a dearth of empirical research that delves deeper to understand this complex and rich phenomenon. Using semi-structured interviews with nine psychodynamic therapists speaking about individual adult patients, this study examined experiences of impasse to better understand treatments that become embroiled in a kind of paralysis. Qualitative analyses revealed dyads where patients were conceptualized as struggling chronically with negative feelings about themselves and others, and who experienced traumatic personal histories. Impasse in and of itself …


Serial Position Effect Profiles And Their Neuroanatomical Correlates: Predictors Of Conversion To Alzheimer's Disease, Isabelle K. Avildsen Sep 2022

Serial Position Effect Profiles And Their Neuroanatomical Correlates: Predictors Of Conversion To Alzheimer's Disease, Isabelle K. Avildsen

Dissertations, Theses, and Capstone Projects

The current study was designed to determine whether targeted, premorbid, neuropsychological measures of the serial position effect (SPE) can detect and explain risk for later development of Alzheimer’s disease (AD). The study tested the utility of SPE measures in healthy controls (HC) and individuals already diagnosed with mild cognitive impairment (MCI) or AD. Aim 1 was to determine whether these sensitive, valid neuropsychological measures can explain disease risk. SPE of list-learning are highly sensitive cognitive markers that capture important elements of both linguistic and amnestic mechanisms of encoding, learning, and retrieval. Using the Rey Auditory Verbal Learning Test (RAVLT), we …