Digital Commons Network^™

Dysregulation Of Complement System In Neuropsychiatric Disorders: A Mini Review, Danny Perez Sierra, Ashutosh Tripathi, Anilkumar Pillai

Faculty, Staff and Student Publications

Complement system is one of the most important defense mechanisms of the innate immune system. In addition to their roles in immune regulation, complement proteins are also involved in neurodevelopment and adult brain plasticity. Complement dysregulation has been shown in neurodevelopmental disorders including schizophrenia and autism spectrum disorder as well as in mood disorders. A number of clinical as well as genetic studies suggest the role of complement proteins in the cortical thinning and excessive synaptic pruning frequently associated with schizophrenia. The changes in complement proteins are also associated with the pathophysiology of autism spectrum disorder, major depressive disorder and …

A Pilot Survey: Retention In Pain Medicine Among Fellowship Trained Anesthesiologists, Sarang S Koushik, Kelly Leap, Kenneth Seier, Kay See Tan, Naum Shaparin, Alan D Kaye, Omar Viswanath, Grant H Chen

Faculty, Staff and Student Publications

BACKGROUND: We aim to explore the factors related to job satisfaction among pain physicians and identify the reasons why individuals minimize or stop practicing outpatient pain medicine.

OBJECTIVES/STUDY DESIGN: This is a survey-based study with the primary goal to identify factors determining job satisfaction and dissatisfaction among pain medicine fellowship graduates who continue to practice and those who are no longer practicing interventional pain. A secondary goal is to elucidate reasons for anesthesiologists trained in pain medicine to leave pain medicine, despite an additional year of training, and to work as general anesthesiologists.

METHODS: In this study, all 114 pain …

Context-Specific Conceptualizations Of Death In Early Childhood, Spencer Hart Winter

Capstone Projects and Master's Theses

Despite cultural myths and social taboos, young children are capable of understanding death and death concepts. Previous research has demonstrated that children have a varied and complex understanding of death that is influenced by their age, family culture, and previous experience. This study aims to differentiate children’s death concept depending on context, including children’s magical thinking, namely the difference between the deaths of a human, an animal, and an electronic toy. Using a modified version of the Death Concept Questionnaire, preschool-aged (3 to 5 years old) children (n=7) were presented with short video clips of a human, a dog, and …

Minimizing Lapses For Weight Control: The Effects Of Cue Exposure And Response Prevention Combined With Distress Tolerance, Meredith Ayers Holland

Dissertations

The current study sought to replicate and extend research into cue exposure and response prevention. Extensions included the addition of a distress tolerance psychoeducation component, delivery of the intervention using videoconferencing technology, and having male and female participants. Daily self-report data was collected using a signal contingent ecological momentary assessment procedure, wherein participants responded to scheduled text messages that went out four times a day. During each exposure session participants responded to questions related to how strong their desire to eat the food was, to their conditioned stimulus-unconditioned stimulus expectancies (CS-US expectancies), and how able they were to tolerate their …

Camp Is For Everyone: Intentional Inclusion Of Gender-Expansive Teens At Camp, Ashley M. Hernandez-Hall, Kimberly H. Zemel

Journal of Youth Development

Camp remains a powerful experience for youth of any age, but special care must be taken to ensure camps are supportive of diverse audiences. This article describes the process by which 4-H camp organizers created a welcoming and affirming camp for teen dependents of active duty, retired, or veteran military personnel, especially those campers who identified as non-binary or LGBTQ+. This included careful consideration of language used in recruitment documents, evaluation documents, volunteer and staff training, as well as communication with campers and families. Through careful planning and implementation, the 4-H adventure camps engaged over 90 teens, and survey results …

A Hybrid Model Of Event Comprehension Predicts Human Activity At Human Scale, Tan Nguyen

Arts & Sciences Graduate Student Theses and Dissertations

To act effectively, humans store event schemas and use them to predict the near future. How are schemas learned and represented in memory, and used in online comprehension? One means to answer these questions is modeling event comprehension. What are, then, computational principles of event comprehension? We proposed three candidate properties: 1) abstract representation of visual features, 2) predictive mechanism and prediction error as feedback, and 3) contextual cues to guide prediction, and adapted a computational model embodying these properties. The model learned to predict activity dynamics from one pass through an 18-hour corpus of naturalistic human activity. Evaluated on …

Beyond The Numbers: A Deeper Dive Into The Dearth Of Girls And Women In Stem, Jennifer John Buck

UNLV Theses, Dissertations, Professional Papers, and Capstones

Despite decades of research attempting to better understand the dearth of girls and women in science, technology, engineering, and math (STEM), gender imbalances persist in many STEM fields. This is particularly the case in math-intensive STEM fields. The current program of research used mixed-methods research to better understand these inequities. The first paper identified gender and ethnic variation in how undergraduates reason about STEM inequities. The second paper found that how emerging adults narrate “turning points” in their relationship with math was associated with their current math outcomes and future plans to pursue math. The final paper demonstrated that how …

The Effects Of Neuroticism And Treatment Delivery Modality On Therapeutic Outcomes In A Community Mental Health Training Clinic, Michelle Elizabeth Sibol

Theses and Dissertations

The onset of the novel Coronavirus Disease 2019 (COVID-19) two and a half years prior to this writing resulted in shifts in everyday life, as individuals worldwide were required to shelter-in-place and abide by social distancing guidelines to slow the spread of the disease. This resulted in a marked increase in the utilization of virtual platforms (“teletherapy”) by mental health care providers, including training clinics, to continue providing therapy services to the community at large. Although the pandemic restrictions have lifted, adaptations made during shelter-in-place mandates remain, including provision of services via teletherapy platforms. The pandemic shed light on the …

Machine Learning Prediction Of Posttraumatic Stress Disorder Trajectories Following Traumatic Injury: Identification And Validation In Two Independent Samples, Carissa W. Tomas, Jacklynn M. Fitzgerald, Carisa Bergner, Cecilia J. Hillard, Christine L. Larson, Terri A. Deroon-Cassini

Psychology Faculty Research and Publications

Due to its heterogeneity, the prediction of posttraumatic stress disorder (PTSD) development after traumatic injury is difficult. Recent machine learning approaches have yielded insight into predicting PTSD symptom trajectories. Using data collected within 1 month of traumatic injury, we applied eXtreme Gradient Boosting (XGB) to classify admitted and discharged patients (hospitalized, n = 192; nonhospitalized, n = 214), recruited from a Level 1 trauma center, according to PTSD symptom trajectories. Trajectories were identified using latent class mixed models on PCL-5 scores collected at baseline, 1–3 months posttrauma, and 6 months posttrauma. In both samples, nonremitting, remitting, and resilient PTSD symptom …

Disharmony Of The Soul: A Philosophical Analysis Of Psychological Trauma And Flourishing, Adam Blehm

Graduate Theses and Dissertations

In this dissertation I argue that psychological trauma hinders human flourishing by disrupting psychic harmony and hindering virtuous relationships. Given the negative symptomology of posttraumatic stress related disorders (i.e., PTSD) this conclusion may seem a bit obvious to some. However, making the case for trauma as a hindrance to human flourishing is more complicated than it may first appear.

First, in the extant literature, trauma as a concept tends to be unclear. In much of the empirical and philosophical literature, trauma can include a certain kind of event, experience, effect, or a combination of all three. Furthermore, because of practical …

Intersectional Identities Of Race And Religion Of African American Muslims And Their Attitudes Toward Seeking Mental Health Services, Cheruba A. Dhanaraj

Dissertations

African American Muslims have overlapping and interconnected identities of race and religion that can be conceptualized by the intersectionality framework to understand the complexities of barriers they face when seeking mental health services. African American Muslims have a higher risk of mental health issues due to systemic racism, racial discrimination, racial trauma, and Islamophobic discrimination. Yet, there is a lack of scholarly research or studies that focus explicitly on African American Muslims' specific mental health needs, barriers, and attitudes related to seeking mental health treatment.

This study sought to fill the gap in knowledge about attitudes toward seeking mental health …

The Real Face Of Borderline Personality Organization Within Intimate Partner Violence, Adriana Isabel Patino

Open Access Theses & Dissertations

This study tests the relationship between IPV perpetration and victimization with BPO. Results indicate that, as predicted, BPO is positively associated with both IPV perpetration and victimization and is more prevalent in female perpetrators and victims than in male perpetrators and victims. However, contrary to what previous literature says, self-control does not show enough significance to state that it is one of the leading causes of IPV perpetrated by those who present traits of BPO. In addition, results also indicate that having suffered from physical abuse during childhood diminishes the probability of perpetrating IPV. To fully understand these results, future …

Exploring Perceptions Of Control Within Offender Cognition And Recidivism Paradigms, Anistasha H. Lightning, Danielle Polage

Student Published Works

Elements of perceived control are associated with recidivism in offender populations. We investigated the application of locus of control to the frequency of personal involvement with the law and to beliefs surrounding the likelihood of future contact with the legal system. We hypothesized that, as the number of sentencings or legal experiences increased, locus of control would externalize. We also predicted that increased legal involvement would lead to greater belief in the likelihood of future involvement. A statistically significant path model suggests that locus of control appears to be a predictor of increased criminality, as opposed to the other way …

White Matter Hyperintensity Load Is Associated With Premature Brain Aging, Natalie Busby, Sarah Newman-Norlund, Sara Sayers, Roger Newman-Norlund, Sarah Wilson, Samaneh Nemati, Chris Rorden, Janina Wilmskoetter, Nicholas Riccardi, Rebecca Roth, Julius Fridriksson, Leonardo Bonilha

Faculty Publications

Background: Brain age is an MRI-derived estimate of brain tissue loss that has a similar pattern to aging-related atrophy. White matter hyperintensities (WMHs) are neuroimaging markers of small vessel disease and may represent subtle signs of brain compromise. We tested the hypothesis that WMHs are independently associated with premature brain age in an original aging cohort.

Methods: Brain age was calculated using machine-learning on whole-brain tissue estimates from T1-weighted images using the BrainAgeR analysis pipeline in 166 healthy adult participants. WMHs were manually delineated on FLAIR images. WMH load was defined as the cumulative volume of WMHs. A positive difference …

Hdac2 In Primary Sensory Neurons Constitutively Restrains Chronic Pain By Repressing Α2Δ-1 Expression And Associated Nmda Receptor Activity, Jixiang Zhang, Shao-Rui Chen, Meng-Hua Zhou, Daozhong Jin, Hong Chen, Li Wang, Ronald A Depinho, Hui-Lin Pan

Faculty, Staff and Student Publications

α2δ-1 (encoded by the Cacna2d1 gene) is a newly discovered NMDA receptor-interacting protein and is the therapeutic target of gabapentinoids (e.g., gabapentin and pregabalin) frequently used for treating patients with neuropathic pain. Nerve injury causes sustained α2δ-1 upregulation in the dorsal root ganglion (DRG), which promotes NMDA receptor synaptic trafficking and activation in the spinal dorsal horn, a hallmark of chronic neuropathic pain. However, little is known about how nerve injury initiates and maintains the high expression level of α2δ-1 to sustain chronic pain. Here, we show that nerve injury caused histone hyperacetylation and diminished enrichment of histone deacetylase-2 (HDAC2), …

Hiv And Early Life Stress On Neuroimaging And Risky Behavior, Paola Garcia Egan

Dissertations

This study examined the interactive effects of early life stress (ELS) and HIV on brain morphometry, diffusion-basis-spectrum-imaging (DBSI), risky decision-making, and sex-risk behavior. 122 people with HIV (PWH) and 113 people without HIV (PWoH), free of major psychiatric illness and neurological confounds, were stratified into high (≥ 3 events) vs. low (< 3 events) ELS [PWoH/low ELS (n = 57), PWoH/high ELS (n =56), PWH/low ELS (n = 43), PWH/high ELS (n = 79)] and underwent structural magnetic resonance imaging, DBSI, neuropsychological, and risky-behavior assessment; all PWH were virologically controlled. Compared to PWoH, PWH had smaller orbitofrontal cortex (OFC), parietal lobes, insula, caudate and anterior cingulate. No ELS effects were detected in volumetric measures. Significant interactions were found between HIV serostatus and ELS on the OFC and on cellularity of the inferior fronto-occipital fasciculus after multiple comparisons adjustment. Specifically, PWH/high ELS exhibited significantly smaller OFC and PWoH/high ELS show significantly larger OFC than the other groups. PWoH/high ELS exhibited higher DBSI cellularity (neuroinflammation proxy) of the inferior-occipital-fasciculus compared to PWoH/high ELS. Regardless of HIV status, executive function moderated the relationship between the OFC and sex-risk behavior such that individuals within the sample who performed above average on a measure of executive function and had a larger OFC reported fewer sex partners in past six months than individuals with smaller volumes. No interaction was found between HIV serostatus and ELS on risky behavior measures. Clustering analyses defined ELS subgroups in PWH that were determined by demographic characteristics, duration of infection, recent CD4+ T-cell count, nadir CD4+ T-cell count and high/low ELS.Even in PWH that are virologically controlled, without major current psychiatric comorbidities, there is evidence of a synergistic impact of ELS and HIV on OFC volumes. Higher volumes in the OFC were detrimental when associated with lower executive function scores or advantageous when associated with higher executive function. Findings suggest that ELS is associated with different brain signatures among PWoH and virally suppressed PWH. However, ELS was not directly associated with risky behaviors, and subgroups in PWH were characterized by demographic variables, past substance use and HIV clinical variables.

Are We Ovary-Acting? All Visuospatial Abilities May Not Be Equally Affected Throughout The Menstrual Cycle., Caroline G. Haynes, Audrey N. Wade

Science University Research Symposium (SURS)

Are we ovary-acting? All visuospatial abilities may not be equally affected throughout the menstrual cycle.

Department of Psychological Sciences & Neuroscience, Belmont University, Nashville, TN

Visuospatial skills pertain to the ability to conceptualize and comprehend visual representations of objects and the spatial relationships among objects. They are integral for the proper functioning of other cognitive systems such as memory, attention, and reasoning (Kaufman, 2007). Sex hormones are one of many factors reported to affect visuospatial processing, with estrogen specially being associated with poor performance on visuospatial tasks in females (Hausmann, 2000). The current study investigated performance differences on three visuospatial …

Responses To Validating Versus Reframing Support Strategies As A Function Of Borderline Personality Features And Interpersonal Problems, Stella Nicolaou, Sydney F. Goldberg, Kaley M. Michael, Kathy R. Berenson

Psychology Faculty Publications

We examined whether borderline personality features may be differentially associated with reactions to social support strategies involving validation (acknowledging distress as normal) vs. reframing (highlighting opportunities for positive outcomes). After completing self-report measures of their borderline personality features and interpersonal problems, participants rated their reactions to receiving either validation or reframing support (randomly assigned) from a close friend with whom they imagined sharing hypothetical negative experiences. Borderline personality features were associated with less positive responses to reframing than to validation, and a tendency to interpret reframing support as an assertion of dominance. Moderated mediation analyses further showed that associations between …

Genome-Transcriptome-Functional Connectivity-Cognition Link Differentiates Schizophrenia From Bipolar Disorder, Jiayu Chen, Zening Fu, Juan R Bustillo, Nora I Perrone-Bizzozero, Dongdong Lin, Jose Canive, Godfrey D Pearlson, Julia M Stephen, Andrew R Mayer, Steven G Potkin, Theo G M Van Erp, Peter Kochunov, L Elliot Hong, Bhim M Adhikari, Ole A Andreassen, Ingrid Agartz, Lars T Westlye, Jing Sui, Yuhui Du, Fabio Macciardi, Faith M Hanlon, Rex E Jung, Jessica A Turner, Jingyu Liu, Vince D Calhoun

Faculty, Staff and Student Publications

BACKGROUND AND HYPOTHESIS: Schizophrenia (SZ) and bipolar disorder (BD) share genetic risk factors, yet patients display differential levels of cognitive impairment. We hypothesized a genome-transcriptome-functional connectivity (frontoparietal)-cognition pathway linked to SZ-versus-BD differences, and conducted a multiscale study to delineate this pathway.

STUDY DESIGNS: Large genome-wide studies provided single nucleotide polymorphisms (SNPs) conferring more risk for SZ than BD, and we identified their regulated genes, namely SZ-biased SNPs and genes. We then (a) computed the polygenic risk score for SZ (PRSSZ) of SZ-biased SNPs and examined its associations with imaging-based frontoparietal functional connectivity (FC) and cognitive performances; (b) examined the spatial …

Bidirectional Leader-Member Exchange And The Impact On Middle Manager Job Satisfaction, Brian A. Collera

Doctoral Dissertations and Projects

Leader-member exchange (LMX) theory focuses on the quality of the relationship between a leader and member. LMX is associated with a number of positive member outcomes, but LMX research has largely neglected what, if any, positive benefits leaders attain from high quality relationships beyond better team performance. The purpose of this study was to apply the LMX theory to middle managers in organizations. Middle managers inherently balance the competing interests of multidirectional relationships, acting as both a leader and a member in the organizational hierarchy. This study explored how middle manager’s self-rating of LMX (relationship with their subordinates), leader-leader exchange …

Childhood Adversities And The Impact On Development, Karey Womack Dulaney

Doctoral Dissertations and Projects

Experiences in life are crucial in determining how one’s development will progress throughout their lifespan, with many of the factors occurring in early childhood. The factors include but are not limited to adversities experienced at an early age, toxic stress, and childhood trauma. Childhood adversities can impact a child’s cognitive development and biological systems. Children living in adverse situations are at a greater risk of not reaching their full developmental potential in life. Although previous research and literature discuss and demonstrate the cruciality of early childhood interventions to mitigate adverse childhood experiences, gaps in the research exist for individual interventions, …

Does Working Memory Predict Preference To Use Inherent Explanations In Scientific Observations? A Bayesian Item Response Theory Approach, Sepideh Namvarrad

Theses - ALL

Understanding the cognitive processes that help people generate explanations is one of the fundamental questions in cognitive science and philosophy. In this study, we try to examine the extent to which working memory capacity can predict peoples’ preference for scientific explanations under uncertainty. Specifically, we distinguish between possible explanations in terms of their focus on inherent vs. extrinsic entities associated with an observation. According to past findings, inherent vs. extrinsic properties of a phenomenon are different in terms of the ease of accessibility for cognitive processes. The results of this research indicate a significant association between people’s tendencies to choose …

Relationship Between Individual Characteristics And Received Social Support Among People With Serious Mental Illness, Samantha Dicorte

USF Tampa Graduate Theses and Dissertations

Past research on social support has mainly focused on perceived social support. Relatively less research has been done on received social support and how it can promote positive behavior outcomes. This study examines the importance of received social support, including background on social support, social support outcomes, and a theoretical foundation overview of the social stress model. In addition to a literature review, this study investigates the association between individual characteristics (i.e., diagnosis and substance abuse including alcohol, race/ethnicity, gender, age, and marital status) and different types of received social support (i.e., daily, mental health, and adherence support). Simple linear …

Cerebral Blood Flow And Cardiovascular Risk Effects On Resting Brain Regional Homogeneity, Bhim M Adhikari, L Elliot Hong, Zhiwei Zhao, Danny J J Wang, Paul M Thompson, Neda Jahanshad, Alyssa H Zhu, Stefan Holiga, Jessica A Turner, Theo G M Van Erp, Vince D Calhoun, Kathryn S Hatch, Heather Bruce, Stephanie M Hare, Joshua Chiappelli, Eric L Goldwaser, Mark D Kvarta, Yizhou Ma, Xiaoming Du, Thomas E Nichols, Alan R Shuldiner, Braxton D Mitchell, Juergen Dukart, Shuo Chen, Peter Kochunov

Faculty, Staff and Student Publications

Regional homogeneity (ReHo) is a measure of local functional brain connectivity that has been reported to be altered in a wide range of neuropsychiatric disorders. Computed from brain resting-state functional MRI time series, ReHo is also sensitive to fluctuations in cerebral blood flow (CBF) that in turn may be influenced by cerebrovascular health. We accessed cerebrovascular health with Framingham cardiovascular risk score (FCVRS). We hypothesize that ReHo signal may be influenced by regional CBF; and that these associations can be summarized as FCVRS→CBF→ReHo. We used three independent samples to test this hypothesis. A test-retest sample of N = 30 healthy …

Science, Technology, Engineering, And Mathematics (Stem) Project-Based Learning (Pbl) Education: A New Mexico Case Study For Equity And Inclusion, Kimberly A. Scheerer

Teacher Education, Educational Leadership & Policy ETDs

This research addresses how student participation in Science, Technology, Engineering, and Mathematics (STEM) project-based learning (PBL) education activities encourages underrepresented minority student achievement in STEM career field trajectories. Seven New Mexico high school counselors and 12 STEM organization personnel were interviewed during this study. Their responses represent the nuanced professional voices where New Mexico public education intersects with STEM student interest and cultural influence.

For students, STEM PBL can foster deep integration across educational disciplines and enhance STEM career trajectory interest and readiness. STEM education converged with PBL methodologies has the ability to leverage community support while broadening student networks. …

Leadership Coaching: Are We Missing The Alchemy?, Raymond L. Forbes

All Faculty and Staff Scholarship

In an era characterized by fear, uncertainty and doubt Leadership Coaches now find themselves operating on more difficult and unfamiliar terrain. Enabling their clients to cope, survive and thrive in such tenuous conditions offers a significant professional challenge. This paper offers an unusual supplemental approach to more conventional and traditional coaching methods. Utilizing principles derived from the ancient field of alchemy, as well as from modern neuroscience, this article provides both new ideas and guidance to the practitioner of leadership coaching. Beginning with a guided imagery, this piece will then cover the connection between alchemy and leadership, followed by alchemy’s …

Exposure To Unpredictability And Mental Health: Validation Of The Brief Version Of The Questionnaire Of Unpredictability In Childhood (Quic-5) In English And Spanish, Natasha G. Lindert, Megan Y. Maxwell, Sabrina R. Liu, Hal S. Stern, Tallie Z. Baram, Elysia Poggi Davis, Victoria B. Risbrough, Dewleen G. Baker, Caroline M. Nievergelt, Laura M. Glynn

Psychology Faculty Articles and Research

Unpredictability is increasingly recognized as a primary dimension of early life adversity affecting lifespan mental health trajectories; screening for these experiences is therefore vital. The Questionnaire of Unpredictability in Childhood (QUIC) is a 38-item tool that measures unpredictability in childhood in social, emotional and physical domains. The available evidence indicates that exposure to unpredictable experiences measured with the QUIC predicts internalizing symptoms including depression and anxiety. The purpose of the present study was to validate English and Spanish brief versions (QUIC-5) suitable for administration in time-limited settings (e.g., clinical care settings, large-scale epidemiological studies). Five representative items were identified from …

Circadian Misalignment And Childhood Obesity: An Unexplored Target For Intervention And Treatment, Mason Pilling

Student Works

Childhood obesity is a pandemic affecting almost 40 million individuals aged 5-18 globally. Many current interventions are relatively successful at treating childhood obesity, yet the rate of childhood obesity continues to increase from year to year, and current intervention methods are struggling to keep up. Mounting evidence suggests that sleep may be a crucial mechanism for understanding and treating obesity, yet sleep still remains a relatively unexplored target for intervention. Circadian misalignment, a measure of the difference between the body’s preferred sleep timing and actual bed and wake times, has been almost completely ignored in the literature, despite preliminary findings …

Integrating Psychopathy Into Prominent Developmental/Life-Course Theories, Eva M. Fontaine

USF Tampa Graduate Theses and Dissertations

Despite empirical research identifying psychopathy as one of the most robust predictors of criminal behavior, calls to integrate psychopathy into criminological theory have largely been unrequited. Within criminological theory, the construct of psychopathy has been proposed to best fit in the developmental/life-course (DLC) paradigm. As such, the purpose of this dissertation was to explore the theoretical integration of into psychopathy into three DLC theories: (1) Moffitt’s (1993) Dual Taxonomy, (2) Gottfredson & Hirschi’s (1990) General Theory of Crime, and (3) DeLisi’s (2009) Unified Theory of Crime. In doing so, the three studies in this dissertation employed the Pathways to Desistance …

Impact Of Adolescent Social Isolation On Adult, Binge-Like Ethanol Consumption And Plasma Corticosterone In High-Alcohol-Preferring Mice, Eva Cullins

The Journal of Purdue Undergraduate Research

Adolescent stress exposure increases the likelihood of alcohol misuse and alcohol use disorder (AUD) in adulthood; however, it is not clear how genetic and environmental factors interact to increase risk. This study examined how adolescent social isolation affects adult binge-like ethanol drinking and levels of the stress hormone corticosterone in male and female mice with a genetic predisposition toward high alcohol preference (HAP). Twenty-eight HAP mice were separated into group-housed (GH) and socially isolated (SI) conditions (n = 13, 13). Binge drinking was assessed using a drinking in the dark (DID) procedure. Blood samples were taken before DID and after …