Digital Commons Network^™

Tiam1 Coordinates Synaptic Structural And Functional Plasticity Underpinning The Pathophysiology Of Neuropathic Pain, Lingyong Li, Qin Ru, Yungang Lu, Xing Fang, Guanxing Chen, Ali Bin Saifullah, Changqun Yao, Kimberley F Tolias

Faculty, Staff and Students Publications

Neuropathic pain is a common, debilitating chronic pain condition caused by damage or a disease affecting the somatosensory nervous system. Understanding the pathophysiological mechanisms underlying neuropathic pain is critical for developing new therapeutic strategies to treat chronic pain effectively. Tiam1 is a Rac1 guanine nucleotide exchange factor (GEF) that promotes dendritic and synaptic growth during hippocampal development by inducing actin cytoskeletal remodeling. Here, using multiple neuropathic pain animal models, we show that Tiam1 coordinates synaptic structural and functional plasticity in the spinal dorsal horn via actin cytoskeleton reorganization and synaptic NMDAR stabilization and that these actions are essential for the …

Occupational Therapist Perceptions On How Eye Movement Therapy Supports Working Memory In Children Diagnosed With Attention Deficit/Hyperactivity Disorder, Latres M. Bell

Doctoral Dissertations and Projects

Previous research reports that children with attention-deficit/hyperactivity disorder (ADHD) show a deficit in their working memory. Working memory is the ability to temporarily manipulate, store, and retrieve information during cognitive tasks. Working memory is considered a critical deficiency in individuals diagnosed with ADHD. Working memory has been shown to be a mechanism for symptoms of disorganization and inattention in individuals diagnosed with ADHD. This qualitative research study reviewed occupational therapists’ perceptions on their role working with children, aged six to 10 years old, diagnosed with ADHD and low working memory, who have had eye movement therapy. The occupational therapists’ perceptions …

Oxytocin Attenuates Yohimbine-Induced Reinstatement Of Alcohol-Seeking In Female Rats Via The Central Amygdala, Samantha M. Wilfur, Elizabeth C. Mcneely, Aliya A. Lackan, Cassie P. Bowers, Kah-Chung Leong

Psychology Faculty Research

Alcohol use disorder is a significant public health concern, further exacerbated by an increased risk of relapse due to stress. In addition, factors such as biological sex may contribute to the progression of addiction, as females are especially susceptible to stress-induced relapse. While there have been many studies surrounding potential pharmacological interventions for male stress-induced ethanol reinstatement, research regarding females is scarce. Recently, the neuropeptide oxytocin has gained interest as a possible pharmacological intervention for relapse. The present study examines how oxytocin affects yohimbine-induced reinstatement of ethanol-seeking in female rats using a self-administration paradigm. Adult female rats were trained to …

Dialectical Behavior Therapy Application Efficacy In The World Of An Athlete: Addressing Special Considerations, John P. Ferraro

Psychology Doctoral Specialization Projects

The current project aimed to analyze the potential that Dialectical Behavior Therapy Skills Training (DBT-ST) could have on the student-athlete population. The project necessitated a research exploration of both DBT and sports psychology treatment. This was accomplished by searching Eastern Kentucky University (EKU) Library’s extensive databases, such as Academic Search Complete, PsycINFO, SportDISCUS, and Psycharticles. Considerations are discussed on athlete-specific concerns, such as stigma, athlete cultural views on mental health, eating disorders, coping through injury, and performance anxiety. Current sport psychology interventions are reviewed, and they are compared with the efficacy of DBT treatment literature. Similarities in sport psychology interventions …

Reclaiming The Past And Transforming Our Future: Introduction To The Special Issue On Foundational Contributions Of Black Scholars In Psychology, Fanita A. Tyrell, Helen A. Neville, José M. Causadias, Kevin O. Cokley, Karlyn R. Adams-Wiggins

Psychology Faculty Publications and Presentations

The contributions of Black scholars to psychology have been erased or marginalized within mainstream, U.S.-centered psychology. As such, psychologists and trainees have little exposure to strengths-based theories and schools of thought that center and humanize the experiences of people of African descent. This special issue intervenes on anti-Black racism at the epistemic level by curating a review of foundational contributions by diverse Black scholars in psychology and related fields. The special issue is organized around five integrative and overlapping themes: (a) Black scholars who have written on topics related to race, racism, and racial identity; (b) schools of thought that …

Understanding The Leaders Of Tomorrow: The Need To Study Leadership In Adolescence, Jennifer L. Tackett, Kathleen W. Reardon, Nathanael J. Fast, Lars Johnson

Psychology Faculty Publications

Leadership traits and behaviors are observed early in human development, and although an improved understanding of youth leadership would usefully inform many real-world contexts (e.g., education, parenting, policy), most empirical work on leadership has been limited to adult populations. The purpose of the current article is to add a developmental perspective to leadership research that has so far been absent. Here, we (a) highlight adolescence as a critical developmental period for leadership emergence and development, (b) argue that leadership among youths is poorly understood and critically understudied, (c) provide exemplars of synergy between research on leadership and adolescent development that …

Validation Of The Addictions Neuroclinical Assessment Among Diverse Individuals With Alcohol Use Disorder, Elena R. Stein

Psychology ETDs

Individuals with alcohol use disorder (AUD) are heterogeneous in terms of etiology, maintenance, symptoms, and recovery, yet current diagnostic categories fail to adequately capture this heterogeneity. Corresponding to the neurobiological addiction cycle, the Alcohol and Addictions Research Domain Criteria proposes a framework of three core domains disrupted in AUD: negative emotionality, incentive salience, and executive function. The Addictions Neuroclinical Assessment (ANA) is a hypothesized multimodal assessment battery of these three domains, which may better characterize AUD heterogeneity. The current study validated the ANA in a sample of drinkers (N=245) who were diverse with respect to ethnicity and alcohol treatment-seeking status. …

What Might David Do In The Face Of Goliath? The Effects Of Height On Status-Signaling Behaviours In Males, Nicole Ruiying Chen

Dissertations and Theses Collection (Open Access)

While the extant literature has looked mainly at how attractive, opposite-sex stimuli impacts our behaviour, much less is known regarding how exposure to same-sex stimuli may also wield influence on human behaviors. Proffering an evolutionary-based perspective, this study aims to investigate, in a sample of heterosexual males, how exposure to taller same-sex stimuli will differentially influence conspicuous status-signaling behaviors of shorter males compared to taller males, in the context of a mating motive. Two competing hypotheses are proposed: (1) shorter males will display greater conspicuous status-signaling compared to taller males in the presence of a tall male confederate and (2) …

Intervening For A Depressed Peer: The Effects Of Resilience Empathy, And History Of Depression, Brendan Weed

Dissertations and Theses @ UNI

No abstract provided.

Analysis Of The Paraventricular Nucleus Of The Hypothalamus After Exposure To Decabromodiphenyl Ether In Mice, Tia Blossomgame, Hermei Herman, Sharlenn La, Jocelyn Saquisili, Annabella Vargas, Grace Martinichio, Vincent P. Markowski

McNair Scholars Program

No abstract provided.

An Exploration Of Racial Trauma And Protective Factors In Black Youth, Daria Chantal Thompson

Theses and Dissertations

Black students’ experiences in school can vary due to racism and discrimination within and outside of the classroom, which can impact their academic progress and overall well-being. In this three-part study, the impact of discrimination is observed to determine if there is a long-term effect of these situations and, if so, determine if there is utility to implement school-based resources to decrease these negative effects. The first study examined whether ethnic-racial socialization in childhood could moderate against symptoms of trauma in young adulthood that were potentially caused by discrimination from peers and teachers in childhood through hierarchical regressions. The second …

Hippocampal Volume And The Detection Of Mild Cognitive Impairment In An Older Adult Population: Assessing Performance On Cognitive Screeners Administered In-Person And Electronically, Kristen Fabrizi

Dissertations

The present study investigated how performance on in-person and electronic neuropsychological assessment measures predicted subcortical hippocampal volume and cognitive decline consistent with mild cognitive impairment. It was hypothesized that the Montreal Cognitive Assessment would display better predictive strength than the Cogstate Brief Battery when evaluating subcortical hippocampal volume measured via structural magnetic resonance imaging. It was further hypothesized that the Montreal Cognitive Assessment would be more sensitive to predicting group membership to the diagnostic classification of mild cognitive impairment compared to the Cogstate Brief Battery. The sample included 445 older adult participants selected from the Alzheimer’s Disease Neuroimaging Initiative 3. …

The Moderating Effect Of Race On Ipts Factors And Suicidal Ideation In A Military Sample, Shelan A. Porter

Research Psychology Theses

Suicide rates have increased over the last 20 years in all ethnic and racial groups in the US, but most prominently for veterans and non-white racial subgroups. Suicidal Ideation is a predictor for suicide but there is limited research looking at mental health differences in the at-risk military community due to race. 794 military personnel were surveyed electronically on a range of mental health measures in a southern US joint forces training center between 2014 and 2015. Guided by the Interpersonal-Psychological Theory of Suicide, this secondary data analysis considered the moderating effect of a three-group race model on the relationship …

No Interest In Being Cynical: Conflicting Versus Corresponding Interests Track Variability In The Link Between Personal Control And Cynicism, Bryan Kwok Cheng Choy

Dissertations and Theses Collection (Open Access)

Recent literature indicates that a lack of personal control negatively predicts (social) cynicism, a negative view of others as self-interested and exploitative (Stavrova & Ehlebracht, 2018a, 2019). Despite the ostensibly robust nature of this relationship, I propose that the strength of the link between personal control and cynicism could be more variable than extant findings have suggested. In particular, I argue that variability in the controlcynicism link may be tracked (i.e., moderated) by the extent to which actors in a situation have corresponding or conflicting interests, with the effect of control on cynicism being attenuated when actors are perceived to …

Continuities And Discontinuities In The Cultural Evolution Of Global Consciousness, R. J. Zhang, J. H. Liu, M. Lee, M. H. Lin, T. Xie, S Chen, Angela K. Y. Leung, I-Ching Lee, D. Hodgetts, E. Valdes, S. Choi

Research Collection School of Social Sciences

Global consciousness (GC), encompassing cosmopolitan orientation, global orientations (i.e. openness to multicultural experiences) and identification with all humanity, is a relatively stable individual difference that is strongly associated with pro-environmental attitudes and behaviours, less ingroup favouritism and prejudice, and greater pandemic prevention safety behaviours. Little is known about how it is socialized in everyday life. Using stratified samples from six societies, socializing institution factors correlating positively with GC were education, white collar work (and its higher income) and religiosity. However, GC also decreased with increasing age, contradicting a 'wisdom of elders' transmission of social learning, and not replicating typical findings …

The Competency To Stand Trial Process In Northern Minnesota And The Effect Time Has On Outcomes, Hannah E. Cornwell

Psychology and Counseling Theses

The current system that manages the competency to stand trial (CST) process in many states is in crisis (Callahan & Pinals, 2020). This is largely due to a significant increase in the amount of people needing competency related services in the last decade (Wik, Hollen, & Fisher, 2019). There have been many solutions proposed by researchers, which include but are not limited to, a screening process for competency to stand trial evaluations, along with shortening deadlines for qualified practitioners to complete evaluations (Gowensmith, 2019). This study examines the effectiveness and efficiency of implementing a screen into the CST process while …

Comparison Between The Effects Of Acute Physical And Psychosocial Stress On Feedback-Based Learning, Xiao Yang, Brittany Nackley, Bruce H. Friedman

Psychology Faculty Publications

Stress modulates feedback-based learning, a process that has been implicated in declining mental function in aging and mental disorders. While acute physical and psychosocial stressors have been used interchangeably in studies on feedback-based learning, the two types of stressors involve distinct physiological and psychological processes. Whether the two types of stressors differentially influence feedback processing remains unclear. The present study compared the effects of physical and psychosocial stressors on feedback-based learning. Ninety-six subjects (Mage = 19.11 years; 50 female) completed either a cold pressor task (CPT) or mental arithmetic task (MAT), as the physical or psychosocial stressor, while electrocardiography and …

Comorbid Adhd And Pediatric Sickle Cell Disease: Prevalence And Risk Factors, Sarah Bills

Theses and Dissertations

Objective: Sickle cell disease (SCD) is a genetic blood condition that places youth at increased risk for deficits in attention and executive functioning suggestive of increased rates of Attention Deficit/Hyperactivity Disorder (ADHD). There is pronounced inconsistency in reported prevalence rates for attention deficits and ADHD diagnoses among youth with SCD, which is due in part to variability in methodology of previous studies. The primary aim of the present study is to use systematic screening to identify the prevalence of inattentive ADHD symptoms and ADHD diagnoses in a pediatric SCD population seen at a large hematology clinic. A secondary aim is …

Feasibility Of A Parent-Focused, Stress Management Intervention To Decrease Adolescent Bmi, Reduce Stress, And Increase Well-Being Among African American Families, Colby J. Kipp

Theses and Dissertations

African American adolescents in the United States experience a higher prevalence of obesity as compared to their White counterparts. This health inequity presents a public health concern as consequences of weight-related chronic diseases often persist into adulthood and are increasingly problematic. As chronic stress has been found to be higher among African American youth compared to White adolescents, it presents as a potential barrier to participation for African American families in health promotion interventions. Additionally, it may be beneficial to target stress in health promotion programs as a modifiable factor in conjunction with health behaviors that may improve outcomes related …

Efficacy Of, And Preference For, A Modification To Differential Reinforcement Procedures, Carissa Basile

Dissertations (1934 -)

Tic disorders, such as Tourette’s Syndrome, are chronic, childhood-onset neurological conditions that involve sudden, repetitive, and involuntary motor movements and/or vocalizations. Individuals with tics often experience a premonitory urge, which is an aversive sensation that occurs right before a tic that may functionally influence tics. Previous research has suggested reinforced tic suppression can effectively reduce tics. Although effective, it may be useful to better understand the behavioral contingencies that most effectively lead to suppression. The purpose of the current study was to compare standard reinforced tic suppression with reinforced tic suppression that included an option for participant-initiated breaks using an …

On-Campus Mental Health Service Use Among College Students With Autism: A Case Study Applying The Andersen Behavioral Model Of Health Services Use, Estella C. Lilyquist

Electronic Theses and Dissertations

The unique set of impairments and limitations presented by students with autism spectrum disorder (ASD) make the accessing of campus-based nonacademic resources more difficult and complicated than their typically developed peers. Each year, the rate of students entering college with disabilities continues to grow, but their mental well-being is relatively poor. The purpose of this qualitative case study was to apply the conceptual framework of the Andersen behavioral model of health services use (ABMHSU) to the experiences of college students with ASD to understand and predict their utilization of campus-provided mental health resources. The participants were seven college students with …

Contextualizing The Neural Vulnerabilities Model Of Obesity, Timothy D. Nelson, Eric Stice

Department of Psychology: Faculty Publications

In recent years, investigators have focused on neural vulnerability factors that increase the risk of unhealthy weight gain, which has provided a useful organizing structure for obesity neuroscience research. However, this framework, and much of the research it has informed, has given limited attention to contextual factors that may interact with key vulnerabilities to impact eating behaviors and weight gain. To fill this gap, we propose a Contextualized Neural Vulnerabilities Model of Obesity, extending the existing theory to more intentionally incorporate contextual factors that are hypothesized to interact with neural vulnerabilities in shaping eating behaviors and weight trajectories. We …

An Analysis Of The Impact And Efficacy Of An Online Mindfulness-Based Intervention As A Support For First-Year University Students, Wyndham Chalmers, Aiden Carthy, Maria Kenneally, Niamh Bruce, Colm Mcguinness, Philip Owende

Articles

As a result of the COVID-19 pandemic, many university courses transitioned to online delivery, therefore, educators and students faced new challenges associated with the delivery of modules and the provision of necessary student supports. Given the scale of this transition, it is likely that many universities will continue to teach remotely far beyond the reach of any pandemic specific restrictions. This study sought to explore the impact and efficacy of a five-week online mindfulness course to a cohort of first year university students (n = 25) at Technological University Dublin (TU Dublin), Ireland. Results demonstrated that participation in the course …

Examining Patient Satisfaction And Treatment Effectiveness For Hispanic Adolescents Receiving Intensive Mental Health Services For Depression, Myesha M. Morgan

USF Tampa Graduate Theses and Dissertations

Behavioral Activation (BA) is a treatment approach that has demonstrated promising outcomes for the adolescent population (Martin & Oliver, 2019). However, more studies are needed to examine its effectiveness with Hispanic adolescents. The prevalence and severity of depressive symptoms tend to be higher among Hispanic adolescents in comparison to their non-Hispanic White peers (Pratt & Brody, 2014). In addition, depressive symptoms are associated with poor social, academic, and later health outcomes (Naicker et al., 2013; Owens, Stevenson, Hadwin, 2012). Given the lack of prior investigations on the effectiveness of BA for Hispanic adolescents, this study aimed to fill a gap …

Unraveling The Neural Basis Of Emotions: Advancing Understanding With Ecologically Valid Paradigms And High-Resolution Intracranial Eeg, Tiankang Xie

Dartmouth College Ph.D Dissertations

Background

Emotion arises from integrating information about the external world with memories of past experiences, current homeostatic states, and future goals. They play a vital role in regulating our thoughts, feelings and behaviors, significantly impacting our mental health. Thus, it is important to understand the neurobiological mechanisms that give rise to emotions. While there has been considerable work investigating the neural basis of emotions, progress has been hampered by several methodological limitations. For example, prior work has relied on relatively simple and isolated stimuli, which often fail to effectively capture the dynamic and multifaceted nature of emotional experiences in real-life …

Oral Microbial Communities In Children, Caregivers, And Associations With Salivary Biomeasures And Environmental Tobacco Smoke Exposure, Jason A. Rothman, Jenna L. Riis, Katrina R. Hamilton, Clancy Blair, Douglas A. Granger, Katrine Katrine Whiteson

Department of Psychology: Faculty Publications

Human oral microbial communities are diverse, with implications for oral and systemic health. Oral microbial communities change over time; thus, it is important to understand how healthy versus dysbiotic oral microbiomes differ, especially within and between families. There is also a need to understand how the oral microbiome composition is changed within an individual including by factors such as environmental tobacco smoke (ETS) exposure, metabolic regulation, inflammation, and antioxidant potential. Using archived saliva samples collected from caregivers and children during a 90-month follow-up assessment in a longitudinal study of child development in the context of rural poverty, we used 16S …

Animal Communication And Sentience, Catia Correia-Caeiro, Katja Liebal

Animal Sentience

Segundo-Ortin & Calvo (S&C) argue for sentience in plants on the basis of several studies of what they describe as "cognitive abilities" in plants. As other commentaries (e.g., Brooks Pribac, 2023; Damasio & Damasio, 2023; ten Cate, 2023) have pointed out, however, there is some misuse of several concepts, and a lack of evidence for sentience. We try to clarify three questions in S&C’s discussion: (1) How is communication defined and conceptualised in animal research? (2) Is plant communication comparable to animal communication? (3) Is communication (or the process we see in plants) a good basis for inferring sentience in …

Depersonalization/Derealization Disorder: Symptomatology In Drug Induced Psychopathology, Eleanor Tietsort

University Honors Theses

Depersonalization/derealization disorder (DPDR) is a severely under-studied mental disorder, regardless of being relatively as prevalent as other serious mental illnesses (SMI) to the general population, such as schizophrenia and obsessive/compulsive disorder (OCD). Due to the nature of the current body of work on the disorder, it's clear there is a need for further research, as there are only a few small scale studies that approach the contradistinction in symptomatology between varying onset triggers. This paper proposes an investigation into whether there is a distinction in severity, duration, and persistence of symptoms between individuals with DPDR triggered by drugs versus non-drug …

Assessing The Correlation Between The Socioeconomic Level And Cognitive Function Among Older Adults In Egypt, Macy Abougabal

Theses and Dissertations

The number of older adults is increasing worldwide at an unprecedented rate. Some countries began to understand the challenges of aging, while others are still at the stage of comprehending the true dimensions of the situation. There is a global focus on aging research to appropriately mitigate the negative impact of aging and cognitive decline. Not only that dementia add economic pressure on governments, it also increase the psychological and physical burden of the caregivers. Scholars have previously studied socioeconomic level in three variables, namely work, education, and income, and their relationship with cognitive function. It was concluded that the …

Snx3 Is Important For Mammalian Neural Tube Closure Via Its Role In Canonical And Non-Canonical Wnt Signaling, Lei Dong, Mengchuan Xu, Yang Li, Wanting Xu, Chengwei Wu, Hanfei Zheng, Zhenyu Xiao, Guochen Sun, Lei Ding, Xiaobo Li, Wenming Li, Liying Zhou, Qin Xia

Faculty, Staff and Student Publications

Cancer cells consistently utilize the unfolded protein response (UPR) to encounter the abnormal endoplasmic reticulum (ER) stress induced by the accumulation of misfolded proteins. Extreme activation of the UPR could also provoke maladaptive cell death. Previous reports have shown that NRF2 antioxidant signaling is activated by UPR and serves as noncanonical pathway to defense and reduce excessive ROS levels during ER stress. However, the mechanisms of regulating NRF2 signaling upon ER stress in glioblastoma have not been fully elucidated. Here we identify that SMURF1 protects against ER stress and facilitates glioblastoma cell survival by rewiring KEAP1-NRF2 pathway. We show that …