Digital Commons Network^™

Low Premorbid Iq May Exacerbate The Cognitive Effects Of Apolipoprotein Ε4 (Apoe Ε4): A Multi-Ethnic Cross-Sectional Study From Habs-Hd, Lubnaa B. Abdullah, Zhengyang Zhou, Ney Alex Alliey, Robert Barber, James Hall, Sid O’Bryant

Psychological Science Faculty Publications

Introduction: Apolipoprotein allele 4 (APOE ε4) is associated with lower IQ scores during childhood and adolescence, but the influence of APOE ε4 and low IQ on late-life cognition is unknown. This study examines the association between APOE ε4 and cognitive outcomes based on premorbid intellectual ability (pIQ) and ethnic background.

Methods: Participants were drawn from the Health & Aging Brain Study–Health Disparities (HABS-HD), categorized by low (z ≤ −2.00) or average (z = 0.00 ± 1.00) pIQ based on word reading scores. Statistical analyses were conducted to evaluate whether APOE ε4 was associated with the cognitive domains of …

A Preliminary Examination Of The Effects Of Moral Elevation On Pain Tolerance, Pain Severity, And Interpersonal Goals, Candice Hayden

Clinical Psychology Dissertations

Despite the abundance of chronic pain treatment research, chronic pain continues to affect an estimated 20% of the world's population; thus, new approaches are likely needed to expand treatment options. One innovative approach to managing chronic pain distress is moral elevation. Moral elevation is an emotion experienced after witnessing an act of virtue, often described as a feeling of being uplifted, inspired, or in awe. Moral elevation has been linked with positive health-related outcomes such as improved mental health symptoms and higher physical quality of life, as well as higher social functioning such as prosocial behavior and a greater sense …

Sex-Specific Effects Of Early-Life Unpredictability On Hippocampal And Amygdala Responses To Novelty In Adolescents, Elysia Poggi Davis, Bianca T. Leonard, Robert J. Jirsaraie, David B. Keator, Steven L. Small, Curt A. Sandman, Victoria B. Risbrough, Hal S. Stern, Laura M. Glynn, Michael A. Yassa, Tallie Z. Baram, Jerod M. Rasmussen

Psychology Faculty Articles and Research

Background

Unpredictable childhood experiences are an understudied form of early-life adversity that impact neurodevelopment. The neurobiological processes by which exposure to early-life unpredictability impact development and vulnerability to psychopathology remain poorly understood. In the current study, we investigated the sex-specific consequences of early-life unpredictability on the limbic network, focusing on the hippocampus and the amygdala.

Methods

Participants included 150 youths (54% female). Early-life unpredictability was assessed using the Questionnaire of Unpredictability in Childhood (QUIC). Participants engaged in 1 or more task–functional magnetic resonance imaging scans between the ages of 8 and 17 (223 total observations) measuring blood oxygen level–dependent (BOLD) …

Exploring Buffering Effects Of Interpersonal Relationships On The Impacts Of Stress On Physical Health, Hadley Freedman, Sophie Forcier, Emma Slatnick, Keely Wright, Kevin M. Summers, Sarah Huff

DU Undergraduate Research Journal Archive

We examined the potential moderating effects of interpersonal relationships on the association between stress and physical health. We hypothesized that there would be a significant main effect of stress on physical health, a significant main effect of relationships on physical health, and a significant interaction between stress and relationship quality on physical health, such that quality relationships provide a buffering effect, reducing the negative impacts of stress on physical health. Data was collected through a self-report Qualtrics survey on CloudResearch. We found a significant main effect of stress on physical health and a significant main effect of relationship quality on …

Exploring Relationships Between Racial Bias, State Empathy, And Perceived Recovery Time Following A Medical Hardship, Kabe Aberle, Lydia Gengler, Madelyn Kavalieros, Brookelyn Mayfield, Kevin M. Summers, Sarah Huff

DU Undergraduate Research Journal Archive

This experiment investigated whether racial biases exist in laypeople's perceptions of recovery time following a common, medically-related hardship and whether these biases can be explained by differential empathy across race. White participants (n=133) read a vignette describing either a White or Black target who experienced a minor car accident. They then rated the amount of time they felt was reasonable for the target to take off from work and normal activities and how much time it would take to recover physically and mentally. Participants also completed measures of state empathy toward the target and their sleep quality. Results …

Du Undergraduate Showcase Abstracts: Research, Scholarship, And Creative Works, Kabe Aberle, Nadia Kako, Kateri Mcrae, Brooke Agulnek, Sky Palmon, Yasmine Ramirez, Francisca Aguirre Beltran, Ashley Juarez, Bridget Kim, Tessa Appel, Sterling Kerr, Spencer Ingley, Gabe Meyer, Robin Tinghitella, Dale Broder, Lily Baeza, Chloe Beers, Julia Coakley, Whitney Kelsey, Sydney Gainforth, Gabi Wing, Audrey Martin, Aaliyah Amore Berry, Brooke Watley, Kiruthika Venkatesan, Rachel Bienstock, Annabella Brotherston, Madison Bryant, Mia Burgener, Emma P. Lieb, Rachel A. Johnson, Jennifer L. Hoffman, Kania Campbell, Kiena Campbell, Courtney Cassidy, Sage Krzyzkowski, Maddox Jones, Skylar Abookire, Luke Hawkins, Sunnah Yoon, Andrea Chu, Yan Qin, Nyah Cubbison, Brian Gearity, Daniel Mcintosh, Mariely Cruz, Edward Garrido, Grady Dionne, Nicole Doris, Lyndsie Salvagio, Ann-Charlotte Granholm-Bentley, Anna Dymov, Hannah Eckert, Gabrielle Welsh, Erica Larson, Charlie Ernst, Anna Zhou, Sarah Watamura, Larissa Fedorovich-Klein, Georgie Fields, Kimberly A. Guevara, Aven Mccall, Ben Peltier, Feruz Yahia, Patrick Flores, Jadyn Floyd, Sophia Forcier, J. Von R. Monteza, Peter Sokol-Hessner, Gwendolyn Geiger, Scott Nichols, Camryn Gunter, Kendal Hengst, Charlie Bednarz, Issy Garside, Addison Baker, Rachel Mina, Brooke Hermanson, Amanda Klingler, William Highfill, Sydney Jaques, Kerstin Lewey, Allison Grossery, Daniel Linseman, Ethan Lim, Jagger Livengood, Owen Mantelli, Gabby Pappas, Abby Mcdonald, Madeleine Dierking, Eve Miller, Emma Loeber, Anna Marlow, Michael Kerwin, Ella Mathews, Hillary Hamann, Khadija Mohamed, Vivian Nguyen, Gabri Notov, Ifunayachi Ogbonna-Ukuku, Sunil Kumar, Charles Baysah, Sarah Olson, Don Sullivan, Anna Paradiso, Jay Parrish, Mira Pronobis, Alisha Pravasi, Kerstin Haring, Diego Ramirez, Christopher Reardon, Juliana Ramirez, Casey Doherty, Ella Kestner, Teagan Weindel, Cate Billings, Pablo Torre-Walter, Lucy Rand, Samantha Reynolds, Mark Siemens, Khadeeja Rashid, Laine Satterlee, Piper Heilbronner, Lily Pound, Ben Whitehurst, Anna Respet, Lizzie Lesoing, Sydney Hertel, Aya Saad-Masri, Brooke Ballenger, Max Proske, Hannah Rosenberg, Ellia Nakahara, Sophia Espinoza, Ivan Woolhouse, Simon Ruland, Gorkem Er, Timothy Sweeny, Melaku Saketa, Michela Schenk, Maren Lynch, Madi Hamm, Grace Schroeder, Michelle Rozenman, Rana Seif, Jackson Hall, Marisela Simental, Daniel Paredes, Aaron Mena, Preston Spaan, Evelyn Stovin, David Andrew Swartz, Anh Tran, Daniel Pittman, Luke Farchione, Emily Boyer, Ukari Verner, Lacey Conrad, Jonathan Velotta, James Weiner, Jagger Gossett, Noah Sherry, Sam Proud, Ben Block, Avi Narayana, Zoey Weiss, Alyssa Wilson, Gabrielle Walsh, David Zonana, Keely Wright, Kena Riveria, Lillybelle Deer, Jena Doom, Elysia Davis, Isabelle Yaremenko, Caitlyn Young

DU Undergraduate Research Journal Archive

Abstracts from the DU Undergraduate Research Showcase.

Experiences Of Managing And Living With Autoimmune Addison’S Disease In The Younger And Newly Diagnosed Adults: An Interpretative Phenomenological Analysis, Mathew Horodner

Walden Dissertations and Doctoral Studies

There is a lack of knowledge regarding the experiences of managing and living with autoimmune Addison’s disease (AD) in the younger and newly diagnosed adults. AD research usually focuses on biological or medication studies. Thus, the purpose of this qualitative study was to understand the lived experiences of the younger and newly diagnosed adults living with autoimmune AD. Consisting of the complex integration of biological, psychological, and social factors, Engel’s biopsychosocial model served as the study’s conceptual framework. I conducted this study to include the experiences of managing and living with autoimmune AD in the younger (18–35) and newly diagnosed …

Big Five Personality Traits As Predictors Of Funeral Directors’ Job Satisfaction, Teresa Busick

Walden Dissertations and Doctoral Studies

By 2037, annual deaths in the United States are expected to exceed 3.6 million, over 1 million more than in 2015. At the same time, the funeral service industry faces a serious staffing problem, with about 50% of funeral directors leaving the profession within 2 years. These combined challenges highlight the need to understand what contributes to job satisfaction and helps to retain these workers in this essential field. This quantitative correlational study examined whether the Big Five personality traits predict job satisfaction among funeral directors. Thus, the Big Five model of personality traits was used to guide the study. …

Effects Of Self-Monitoring On Teachers’ Behavior-Specific Praise And Students’ Behavior In A Center-Based Classroom, Samantha Walsh

Theses

The current study explores the effects of self-monitoring on teachers' use of behavior-specific praise (BSP) and its impact on student behavior in a center-based classroom. Self-monitoring, a cost-effective and time-efficient intervention, has been proven effective in previous research for enhancing educator performance. However, previous studies have often combined self-monitoring with other interventions, leaving a gap in understanding its effects in isolation. This study aims to replicate the work of Justus et al. (2023) by examining the impact of self-monitoring on paraprofessionals in a center-based classroom with students aged 6-10. Using a multiple baseline design across participants, three paraprofessionals were trained …

A Systematic Review Of Flotation-Restricted Environmental Stimulation Therapy (Rest), Elnaz Lashgari, Emma Chen, Jackson Gregory, Uri Maoz

Psychology Faculty Articles and Research

Background

Restricted Environmental Stimulation Therapy (REST) is a therapeutic technique that involves immersing an individual in an environment with minimal sensory input or stimulation. The goal of REST is to induce a state of relaxation that is deeper than what can be achieved through other forms of relaxation techniques. Research suggests that REST can help reduce anxiety, alleviate chronic pain, improve sleep, and enhance creativity and cognitive function. Flotation-REST is a popular type of REST that utilizes an enclosed tank filled with buoyant saltwater to facilitate relaxation. This study aimed to synthesize the evidence on studies that investigate the effects …

Community Members’ Perspectives On A Community-Engaged Process For Supporting Vibrant Greenspaces In Detroit, Alysha D. Matthews, Guilherme Hebling Costa, Karl Erickson, Karin A. Pfeiffer, Amber L. Pearson, Benjamin V. Dougherty

Journal of Community Engagement and Higher Education

Greenspaces provide several well-being (Dinnie et al., 2013) and psychosocial benefits (Addy et al., 2004). Community-engaged research affords community partners a voice in the project (Cushman et al., 2004). This study assessed Detroit community members’ perceived benefits of and suggestions for engaging with the community to support greenspaces. Through qualitative analysis, a three-step process for community-engaged planning was revealed. Findings highlight strategies that involve community members in this process to enhance community engagement and well-being.

It Starts At Home: An Exploration Of Family Ethnic-Racial Socialization And Depressive Symptoms Among Biracial Black-White Young People, Ashley M. Dominguez, Mckenzie N. Green

McNair Journal at VCU

Abstract

A growing body of literature has suggested that ethnic-racial socialization (ERS) is a protective factor for Biracial youth as it can provide youth with skills to face different adversities like racial discrimination, ultimately improving their psychological well-being. Various types of ERS exist (e.g., verbal, non-verbal, etc) across different levels (e.g., parent-child, household/family) but some have been overlooked and understudied in research. This study sought to bridge this gap by exploring ERS at the family/household level and determining whether it relates to depressive symptoms among Biracial Black-White adolescents and emerging adults (N = 723). Specifically, the study examined if (a) …

Investigating Individual Variability In Autistic Identity And Its Moderating Effects On Mental Health And Quality Of Life, Sydney Richelle Terroso

Theses and Dissertations

The autistic community has long voiced the mental health of autistic adults as a key clinical and research priority. Autistic identity, or the recognition and embrace of core autistic traits as integral to an individual's identity as a whole, may be a potential target for therapeutic approaches aimed at supporting well-being and quality of life. The current study investigates individual differences in self-reported autistic identity scores by demographic factors and by features of autism and health history using online survey data from N=225 autistic adults. Additionally, with a subset of the participants who completed an interconnected study of current mental …

Social Comparison Target Selections As Health Information Preferences: Exploring Contextual Influences Among Women In Midlife With Elevated Risk For Cardiovascular Disease, Emmanuel Lapitan

Theses and Dissertations

Insufficient physical activity (PA) heightens the risk of chronic illnesses including cardiovascular disease (CVD), particularly among women in midlife with conditions such as hypertension. Behavioral interventions often use psychoeducation and skills training to increase PA, but how individuals interact with health-relevant information and how this relates to daily PA behavior is unclear. Health information preferences vary between individuals, but whether they vary for the same individual across contexts has been understudied. In particular, the role of contextual factors in predicting social comparison (i.e., evaluating oneself relative to others to obtain information about oneself) are not well understood. The purpose of …

Religious Beliefs, Cooperation, And Evolutionary Mechanisms, Nicole Fellice Ko, Norman P. Li

Research Collection School of Social Sciences

Religion is an organized system of spiritual beliefs, practices, and rituals that often involve a sense of the divine (Schilbrack, 2022). An evolutionary mechanism is an evolved set of traits that interpret environmental inputs and generate behavioral responses that enhance survival or reproductive success (Li et al., 2018). Cooperation refers to the act of individuals or groups working together to achieve a shared goal or mutual benefit (Alós-Ferrer & Garagnani, 2020).

The Moderating Effects Of Religious Support And Family Support Between Racial Discrimination And Psychological Health Outcomes Among Black Adolescents, Tiera Cleveland

Theses and Dissertations

Racial discrimination is a common experience for Black adolescents. This study aimed to examine family support and religious support as a moderating variable between discrimination and mental health among Black adolescents. This study utilized data from an existing data set, the National Survey of American Life-Adolescent (NSAL-A). The NSAL-A included 1170 adolescents: 810 African American¹ and 360 Black Caribbean². The sample contained an equal amount of female (n = 608) and male (n = 562) Black adolescents³, who range in age from 13 to 17 years. Significant findings suggest that family support moderates the impact …

Deprivation And Threat As Predictors Of Executive Functioning And Emotion Regulation In Early Adolescence: The Protective Role Of School Support, Abigail Best De Arellano

Theses and Dissertations

Childhood adversity (CA) impacts a large proportion of US youth with far reaching consequences for development and subsequent health outcomes (McLaughlin et al., 2012). Given the widespread impact of CA, it is imperative to understand how these exposures impact development, as well as identify opportunities for intervention. McLaughlin and Sheridan (2016) proposed the Dimensional Model of Adversity of Psychopathology (DMAP), providing a framework for understanding the heterogeneity of outcomes related to exposure to CA. DMAP emphasizes that deprivation (i.e., lack of expected cognitive or social stimulation) and environmental threat (i.e., exposure to harm or the threat of harm) impacts youth …

Effects Of Verbal Tasks On Driving Simulator Performance, Jonathan Cheshire Rann

Theses and Dissertations

We report the results from a driving simulator paradigm we developed to test the effects of simple verbal tasks on simultaneous driving performance. A total of 74 undergraduate students participated in two experiments in which they controlled a car using the steering wheel to track a moving target. The dependent measure, overall deviation from target, was continuously recorded. Experiment 1 (E1) tested tracking performance during slow and fast target speeds under conditions involving either no verbal input or output (Absent), passive listening to spoken prompts via headphones (Listen), or responding to the spoken prompts (Respond). Experiment 2 (E2) was similar …

Stimulation Of The Rostromedial Tegmental Nucleus Induces Long-Lasting Avoidance Behavior, Jacob Ryan Watson

Theses and Dissertations

The role of midbrain dopamine (DA) activity in reward seeking and reinforcement learning is well-documented, contrasting the lesser-understood impact of inhibitory signaling on DAergic activity, especially in the context of aversive learning and avoidance. The rostromedial tegmental nucleus (RMTg) is a GABAergic midbrain structure activated by aversive stimuli and exerts inhibitory influence over ventral tegmental area (VTA) DAergic activity in response to aversive consequences. Stimulation of the RMTg decreases the firing rate of VTA DA neurons and direct inhibition of the RMTg – VTA circuit enhances persistent reward seeking despite aversive consequences, a major criterion of substance use disorder (SUD). …

Examination Of An Experimental Paradigm Of Impaired Control Over Alcohol Use, Emily K. Junkin

Psychology Theses & Dissertations

Alcohol use disorders peak during young adulthood with nearly 27% of individuals aged 18 to 30 meeting diagnostic criteria. Impaired control, or difficulty limiting alcohol use, has been identified as one of the earliest symptoms of an alcohol use disorder and is predictive of alcohol use severity. Despite the relevance of impaired control for identifying and preventing hazardous drinking behaviors, there is a dearth of research that exists on this critical risk factor. The current study tested an experimental paradigm of impaired control whereby participants self-administered alcohol following guidelines to limit consumption to a low level. It was hypothesized that …

The Relationships Between Expectancy-Value Beliefs, Communal Value Beliefs, Family Identity, And Academic Persistence Among First- And Continuing-Generation College Students, Douglas W. Snuffer

STEMPS Theses & Dissertations

First-generation college students (students for whom neither parent has a 4-year college degree) have lower college graduation rates than their continuing-generation peers (Cahalan et al., 2021; Fry, 2021). First-generation students may experience barriers to higher education, leading to lower levels of academic achievement motivation for college. Two of these barriers may include 1) cultural mismatch (Stephens, Fryberg, et al., 2012) with colleges via communal value (a value set that emphasizes community and family over the self) and 2) a strong sense of family identity, which lends itself to perceived family obligations (Fuligni et al., 2007). To examine the relationships between …

Definition And Classification Of Dystonia, Alberto Albanese, Kailash P Bhatia, Victor S C Fung, Mark Hallett, Joseph Jankovic, Christine Klein, Joachim K Krauss, Anthony E Lang, Jonathan W Mink, Sanjay Pandey, Jan K Teller, Marina A J Tijssen, Marie Vidailhet, H A Jinnah

Faculty, Staff and Students Publications

Dystonia is a movement disorder with varied clinical features and diverse etiologies. Here we present a revision of the 2013 consensus definition and classification of dystonia in light of subsequent publications and experience with its application during the last decade. A panel of movement disorder specialists with expertise in dystonia reviewed the original document and proposed some revision. There was broad consensus to retain the definition of dystonia with only minor clarifications to the wording. Dystonia is defined as a movement disorder characterized by sustained or intermittent abnormal movements, postures, or both. Dystonic movements and postures are typically patterned and …

Atypical Beta Oscillatory Dynamics Are Related To Poor Procedural Learning In Children With Developmental Coordination Disorder, Jarrad A.G. Lum, Kaila M. Hamilton, Li Ann Leow, Welber Marinovic, Ian Fuelscher, Pamela Barhoun, Talitha C. Ford, Aron T. Hill, Samaneh Nahravani, Melissa Kirkovski, Peter G. Enticott, Christian Hyde

Research outputs 2022 to 2026

Procedural learning difficulties are commonly reported in children with developmental coordination disorder (DCD), yet the neural basis of this impairment remains unclear. This study addressed this gap by examining the correlation between cortical oscillatory activity and procedural learning of a sequence of finger movements in children with and without DCD. Participants were 19 children with DCD and 38 typically developing (TD) children, with a mean age of 10 years and 3 months. Children completed the Serial Reaction Time task, a standard measure of procedural learning, during which they unintentionally learned a sequence of finger movements. Electroencephalography (EEG) was continuously recorded …

Sex-Dependent Modulation Of Behavioral Allocation Via Ventral Tegmental Area-Nucleus Accumbens Shell Circuitry, Kristen A. Mclaurin, Jessica M. Illenberger, Hailong Li, Rosemarie M. Booze, Charles F. Mactutus

Faculty Publications

Diagnostic criteria for substance use disorder, cocaine type (i.e., cocaine use disorder), outlined in the 5th edition of the Diagnostic and Statistical Manual of Mental Disorders, imply that the disorder arises, at least in part, from the maladaptive allocation of behavior to drug use. To date, however, the neural circuits involved in the allocation of behavior have not been systematically evaluated. Herein, a chemogenetics approach (i.e., designer receptors exclusively activated by designer drugs (DREADDs)) was utilized in combination with a concurrent choice self-administration experimental paradigm to evaluate the role of the mesolimbic neurocircuit in the allocation of behavior. Pharmacological activation …

Adapting A Personalized Normative Feedback Intervention For Graduate Student Drinkers, Faith Shank

Theses and Dissertations

On average, graduate students consume eight drinks per week, meeting criteria for heavy drinking and highlighting the need for a cost-effective intervention. The current study examined the efficacy of personalized normative feedback (PNF) for reducing heavy drinking in graduate students. Study 1 examined the feasibility and acceptability of the intervention content to inform a randomized controlled trial (RCT) of the intervention. Results from qualitative interviews with 13 graduate students who interacted with the intervention content preferred to receive feedback about peers enrolled in the same type of degree program. Study 2 was an RCT using PNF from peers with the …

Study Of Religious Experience Using The Introspection Method: Case Of Estonia, Siim Nigulas, Tõnu Lehtsaar

Occasional Papers on Religion in Eastern Europe

This article revisits the method of introspection as a valuable tool for studying religious experience in Estonia, where spirituality is often personal, unaffiliated, and deeply introspective. Drawing on the legacy of the Dorpat school—particularly Karl Girgensohn—it highlights how experimental introspection can illuminate the dimensions of faith. Considering Estonia’s post-Soviet religious individualization, the method offers a culturally fitting and academically rigorous approach. The study argues for the revival and adaptation of introspective techniques to explore the inner dynamics of belief in a secular yet spiritually curious society.

A Call For Change: Supporting Children With Tourette Syndrome, Matt Reall

Journal of Nonprofit Innovation

Tourette Syndrome affects 1 in 100 U.S. children but remains widely misunderstood due to stigma, delayed diagnosis, and media misrepresentation. This neurological disorder is characterized by involuntary tics and often co-occurs with ADHD, anxiety, and sleep disorders. Children with Tourette Syndrome face disproportionate challenges in social, academic, and emotional settings—despite having average or above-average intelligence. One-third engage in self-harm, and suicide rates are four times the national average. Peer-education programs like the Tourette Association of America’s Youth Ambassador initiative have shown promise in reducing stigma, but unequal access and weak institutional support limit their impact. This paper calls for early …

Finding Strength In The Broken Places: Examining The Influence Of Aces On The Mother/Daughter Relationship, Taressa R. Copeland

Doctoral Dissertations and Projects

Daughters raised by mothers who experienced childhood adversity may be ill-equipped for motherhood themselves due to the mother’s guilt and societal stigma associated with the adversity and the impact on lived experiences. Current studies fail to consider the bidirectional influence of adverse childhood experiences (ACEs) on the mother-daughter relationship. Community stakeholders such as healthcare providers must find a way to support the mother-daughter relationship by providing a safe platform to share and understand experiences as well as identify opportunities for resilience. Resources are also necessary to raise awareness and support mental health. This study used a qualitative phenomenological approach to …

The Relationship Between Hope, Religiosity, And Meaning In Life In Adults Who Experienced Relational Loss, Elyse Hope Linder

Doctoral Dissertations and Projects

Relationship loss from death or living loss significantly impacts almost every human being at some point in life. Extensive research has examined the constructs of hope, religiosity, meaning in life, and grieving. Researchers have identified the contributions of these constructs in helping individuals understand and make sense of relational loss. However, limited, if any, literature exists on the relationships between all the constructs, particularly with an interdisciplinary view of hope. This present study examined these relationships and the moderating effect of hope and religiosity in adults who have experienced significant relationship loss within the past six years. Data was collected …

Exploring Predictors Of Treatment Response To Glp-1 Receptor Agonists For Smoking Cessation, Luba Yammine, Constanza De Dios, Robert Suchting, Charles E Green, David A Nielsen, Consuelo Walss-Bass, Joy M Schmitz

Faculty, Staff and Student Publications

Introduction: Understanding predictors of smoking cessation medication efficacy facilitates the ability to enhance treatment effectiveness. In our pilot trial, exenatide, a glucagon-like peptide-1 receptor agonist, adjunct to nicotine patch improved smoking abstinence compared to nicotine patch alone. This secondary analysis explores potential baseline characteristics associated with differential treatment response to exenatide.

Aims and methods: The parent trial randomized (1:1) 84 smokers with prediabetes and/or overweight to once-weekly placebo or exenatide, 2 mg, subcutaneously. All participants received nicotine patch (21 mg) and brief smoking cessation counseling, with biologically confirmed 7-day point prevalence abstinence at week 6 (end-of-treatment) deemed the primary outcome. …