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Effect Of Stress, Emotional Lability And Depression On The Development Of Pregnancy Complications, Servitje, Estibalitz Laresgoiti Servitje Jan 2011

Effect Of Stress, Emotional Lability And Depression On The Development Of Pregnancy Complications, Servitje, Estibalitz Laresgoiti Servitje

Walden Dissertations and Doctoral Studies

Chronic stress and other emotional factors may have relevant impacts on pregnancy outcomes because they are related to neuroendocrine changes that lead to alterations in immunomodulation during pregnancy. In this quantitative prospective cross-sectional study, the relationship of emotional lability, depression, and stress during pregnancy and the development of preterm labor, preeclampsia, placental abruption, and low birth weight for gestational age babies was examined. Additionally, social support scores were compared to levels of stress/anxiety, depression, and emotional lability in pregnant women. Two hundred and forty two pregnant women who received prenatal services at the National Institute of Perinatology in Mexico City …

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Polyamine Modulation In Alcoholism: Examination Using A Novel Screening Procedure Designed To Predict Anti-Relapse And Neuroprotective Efficacy, J. Ben Lewis Jan 2011

Polyamine Modulation In Alcoholism: Examination Using A Novel Screening Procedure Designed To Predict Anti-Relapse And Neuroprotective Efficacy, J. Ben Lewis

University of Kentucky Doctoral Dissertations

Alcohol dependence is a major public health concern. Despite the FDA’s approval of multiple anti-relapse drugs, relapse rates remain unacceptably high. Furthermore, cognitive deficits among chronic drinkers are evident and are suggested to contribute to relapse risk. Current evidence suggests that several critical features of alcoholism and alcohol-associated neurodegeneration are mechanistically linked to glutamatergic actions; specifically, they appear positively affected by glutamatergic inhibition, particularly inhibition via polyamine modulation of a subpopulation of n-methyl-d-aspartate receptors. The current project was designed to evaluate the performance of two putative polyamine modulators (JR-220 and CP-101,606) in a variety of screens designed …

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Neural Mechanisms Of Interference And Storage In Vibrotactile Working Memory, Tyler D. Bancroft Jan 2011

Neural Mechanisms Of Interference And Storage In Vibrotactile Working Memory, Tyler D. Bancroft

Theses and Dissertations (Comprehensive)

Vibrotactile working memory has attracted increasing attention in recent years. Substantial research into the neural correlates has been conducted, especially using single-cell paradigms in non-human primates (Romo & Salinas, 2003). The vibrotactile working memory system uses a relatively simple neural code for the representation of stimuli, making it possible to determine when stimulus information is present in the various cortical areas thought to be involved. In humans, vibrotactile working memory displays properties (such as overwriting mechanisms of interference) that make it an ideal system for testing general theories of working memory. In the present study, we demonstrate that vibrotactile working …

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Pulsed Radiofrequency Neuromodulation Of Peripheral Nerve Injury, Alex Willett Jan 2011

Pulsed Radiofrequency Neuromodulation Of Peripheral Nerve Injury, Alex Willett

Honors Projects

Pulsed-radiofrequency neuromodulation (PRF) is a pain management technique that involves placing a needle electrode near nerves and generating electrical current pulses in order to modulate the transduction of somatosensory information through those nerves. This technique evolved from a similar radiofrequency (RF) procedure in which constant current is distributed to a nerve or neural structure. RF interrupts nerve conduction and prevents somatosensory information from reaching the brain. In the case of continuous radiofrequency, however, the destructive lesion can cause further complications and unwanted side effects. According to research, PRF, unlike RF, is non-destructive yet still induces analgesia and consequently represents a …

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An Examination Of The Relationship Between Positive Psychological Functioning And Depression, John Forbes Jan 2011

An Examination Of The Relationship Between Positive Psychological Functioning And Depression, John Forbes

Theses: Doctorates and Masters

With unipolar depression one of the most disabling illnesses in the world, it is important to appropriately conceptualise this disorder in order to inform research, diagnosis, and treatment. While many psychological theories of depression include constructs of polarity, most research and diagnostic criteria have focused on a single dimension that concentrates on the presence of negative symptomatology. This is reflective of an illness model of mental health that predominantly considers the presence of negative symptoms in terms of mood, cognitions, behaviours, and overall functioning. Nevertheless, there is strong research evidence indicating that positive and negative aspects of psychological functioning are …

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The Role Of Task-Appropriate Processing, Context, And Attention Allocation In Prospective Memory: A Multinomial Modeling Approach, Benjamin Anderson Martin, Ii Jan 2011

The Role Of Task-Appropriate Processing, Context, And Attention Allocation In Prospective Memory: A Multinomial Modeling Approach, Benjamin Anderson Martin, Ii

LSU Doctoral Dissertations

This study investigated the influences of attention and retrospective memory processes on prospective memory. In Experiment 1, participants who processed prospective memory cues under conditions that did not coincide with the processes required for making judgments in an ongoing task showed greater levels of performance at the expense of the attentional resources needed to complete the ongoing task. This differed compared to participants who processed cues under conditions that required the same processes needed to performance the ongoing task. In Experiment 2, the reinstatement of contextual features associated with prospective memory cues from the time of intention formation, or encoding, …

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Assessing Social Support In Children: Development And Initial Validation Of The Social Support Questionnaire For Children, Arlene Tayag Gordon Jan 2011

Assessing Social Support In Children: Development And Initial Validation Of The Social Support Questionnaire For Children, Arlene Tayag Gordon

LSU Doctoral Dissertations

Research examining risk and protective factors associated with Posttraumatic Stress Disorder (PTSD) in children has established social support as one of the strongest predictors of psychological health and overall adjustment post-traumatic event (Vigil & Geary, 2008). Greater perceived social support, generally, has been related to more positive outcomes in children (Borja & Callahan, 2008; Cryder, Kilmer, Tedeschi, & Calhoun, 2006; Pina, Villalta, Ortiz, Gottschall, Costa, & Weems, 2008). Understanding the impact of social support on coping with traumatic events such as natural disasters or exposure to community violence is limited by the lack of psychometrically sound measures. The current study …

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Assessing Attentional Bias And Cerebral Laterality In Specific Phobia Using A Dichotic Listening Paradigm, Whitney Shay Jenkins Jan 2011

Assessing Attentional Bias And Cerebral Laterality In Specific Phobia Using A Dichotic Listening Paradigm, Whitney Shay Jenkins

LSU Master's Theses

Researchers have found fear to impact a variety of cognitive variables in individuals with specific phobia. Attentional bias is a cognitive variable that has received considerable attention in the specific phobia literature; however, the existing literature follows only one line of attentional bias—bias as encoded through images, words, or other content presented visually. This study aimed to expand on this area by assessing attention and cerebral laterality in individuals with specific phobia using a dichotic listening paradigm (i.e., via auditory means). Results indicated that participants with specific phobias do not significantly differ from controls in terms of the number of …

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Relationships Among The Behavioral Inhibition System, Response Inhibition, Heart Rate Variability, And Anxiety Sensitivity Between Older Adolescents With And Without Significant Anxiety, Erin Tarcza Reuther Jan 2011

Relationships Among The Behavioral Inhibition System, Response Inhibition, Heart Rate Variability, And Anxiety Sensitivity Between Older Adolescents With And Without Significant Anxiety, Erin Tarcza Reuther

LSU Doctoral Dissertations

Differences in the Behavioral Inhibition System (BIS; Gray, 1982), response inhibition, and cardiac vagal control are evident between individuals with anxiety and nonclinical control participants. In this study, the role of inhibition in anxiety was examined, as well as relationships between the primary indexes of inhibition including the behavioral inhibition system (BIS), response inhibition, and cardiac vagal tone (or heart rate variability) at rest and during tasks of response inhibition. Additionally, anxiety sensitivity, an established risk factor for developing anxiety disorders, was examined and how it relates to indexes of inhibition. As expected, inhibition and anxiety sensitivity were found to …

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The Relationship Between Visual Attention And Prospective Memory, Noelle L. Brown Jan 2011

The Relationship Between Visual Attention And Prospective Memory, Noelle L. Brown

LSU Doctoral Dissertations

The current study examined the role of attention in prospective memory. Prospective memory refers to the ability to form an intention to do something in the future, such as email a colleague, and additionally remembering to do so at the appropriate moment. Theories of prospective memory retrieval suggest that attention is required to complete an intention. However, the exact role of attention and whether it is always required remains unclear. One challenge in examining the allocation of attentional resources in prospective memory is that a direct measure of these resources does not exist. The current study attempted to address this …

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Repeated Binge Pattern Ethanol Administration During Adolescence Or Adulthood: Long-Term Changes In Voluntary Ethanol Intake And Mesolimbic Dopamine Functionality In Male Rats, Antoniette Michelle Maldonado-Devincci Jan 2011

Repeated Binge Pattern Ethanol Administration During Adolescence Or Adulthood: Long-Term Changes In Voluntary Ethanol Intake And Mesolimbic Dopamine Functionality In Male Rats, Antoniette Michelle Maldonado-Devincci

USF Tampa Graduate Theses and Dissertations

Binge alcohol consumption is a rising concern in the United States, especially among adolescents as during this developmental period alcohol use is usually initiated and has been shown to cause detrimental effects on brain structure and function. These findings have been established through the use of binge models in animals, where animals are repeatedly administered high doses of ethanol typically over a period of three or four days. While such work has examined the effects of a four-day and repeated three-day binge, there has been almost no work conducted aimed at investigating the long-term behavioral and neurochemical and/or functional consequences …

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Effects Of Delayed Auditory Feedback On Young Infants’ Crying, Sarah M. Sanborn Dec 2010

Effects Of Delayed Auditory Feedback On Young Infants’ Crying, Sarah M. Sanborn

Master's Theses

Neural control of newborn crying has typically been considered to originate primarily in the lower brain centers, although support for this assumption is limited. To address this, the present study manipulated newborn infants’ perceptual experience during a cry bout through use of delayed auditory feedback (DAF). Atypical cry productions during DAF would suggest that newborn crying is under higher levels of cortical control than previously assumed. Infants’ spontaneous crying was recorded for 2 minutes at 4 weeks of age (n=16) and again at 8 weeks of age (n=17) using an ABA design, alternating synchronous feedback with DAF. Standard repeated-measures 2 …

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Effects Of Embodiment On Perceptual And Affective Responses To Infant Crying, Jennifer B. Bisson Dec 2010

Effects Of Embodiment On Perceptual And Affective Responses To Infant Crying, Jennifer B. Bisson

Master's Theses

Three experiments were conducted to investigate how changes in bodily states might be related to perceptions of infant vocalizations. In Study 1, participants were asked to hold a pencil between their lips, mimicking a smile, while listening to infant crying. Although there were no embodied effects for perceptual ratings, results indicated that this manipulation decreased participants’ self-reported, negative affect. In Study 2, participants were played both infant crying and birdsong while exposed to similar embodied manipulations, including activation of muscles related to approach and withdrawal behavior. There were no embodied effects for ratings of crying or for affect. Comparing Study …

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Posttraumatic Stress Among Young Urban Children Exposed To Family Violence And Other Potentially Traumatic Events, Cindy A. Crusto, Melissa L. Whitson, Sherry M. Walling, Richard Feinn, Stacey R. Friedman, Jesse Reynolds, Mona Amer, Joy S. Kaufman Dec 2010

Posttraumatic Stress Among Young Urban Children Exposed To Family Violence And Other Potentially Traumatic Events, Cindy A. Crusto, Melissa L. Whitson, Sherry M. Walling, Richard Feinn, Stacey R. Friedman, Jesse Reynolds, Mona Amer, Joy S. Kaufman

Psychology Faculty Publications

This study examines the relationship between the number of types of traumatic events experienced by children 3 to 6 years old, parenting stress, and children's posttraumatic stress (PTS). Parents and caregivers provided data for 154 urban children admitted into community-based mental health or developmental services. By parent and caregiver report, children experienced an average of 4.9 different types of potentially traumatic events. Nearly one quarter of the children evidenced clinically significant PTS. Posttraumatic stress was positively and significantly related to family violence and other family-related trauma exposure, nonfamily violence and trauma exposure, and parenting stress. Additionally, parenting stress partially mediated …

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Learned Attention In Younger And Older Adults, Jared M. Holder Dec 2010

Learned Attention In Younger And Older Adults, Jared M. Holder

Masters Theses & Specialist Projects

A relatively new phenomenon in learning research called highlighting occurs when participants show a seemingly irrational preference to attribute a stronger cue-outcome association to a later presented perfect predictor when it is paired with an imperfect predictor than that of an earlier presented perfect predictor paired with the same imperfect predictor (Kruschke, 1996). Current research suggests that the highlighting effect depends on the ability to learn to shift attention away from an irrelevant cue toward a more relevant cue in order to reduce errors in causal judgment and preserve an earlier formed association (Kruschke, 2003). Much research has suggested that …

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Essences And Transformations In Objects, Animals, And Humans, Alicia Brooke Smith Dec 2010

Essences And Transformations In Objects, Animals, And Humans, Alicia Brooke Smith

Masters Theses & Specialist Projects

Research as to how humans group natural kinds, such as animals, is essential to understanding categorization processes. However, it lacks conventional application and generalization to everyday life. Humans are social beings that encounter a wide array of individuals on a daily basis. In these situations, we are required to consider various properties that make up these people. As Keller (2005) suggests, the way we categorize is shaped by our theories about the world. Therefore, when we determine the rationale behind people’s social categorization processes, we are better able to understand people’s perceptions of their social environment. Moreover, when we conduct …

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Personality And Politics: Introduction To The Special Issue, Lauren E. Duncan, Bill E. Peterson, Eileen L. Zurbriggen Dec 2010

Personality And Politics: Introduction To The Special Issue, Lauren E. Duncan, Bill E. Peterson, Eileen L. Zurbriggen

Psychology: Faculty Publications

This special issue of Journal of Personality brings together 10 original articles addressing the intersection of personality and politics. Articles build on classic traditions in political psychology by presenting both idiographic and nomothetic work on the motivational, cognitive, ideological, attitudinal, and identity correlates of many different aspects of political behavior. This work is used to understand political activism and leadership as well as everyday political behavior. We hope this collection of articles will inspire our readers to explore new investigations in personality and political psychology.

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Universal Biases In Self-Perception: Better And More Human Than Average, Steve Loughnan, Bernhard Leidner, Guy Doron, Nick Haslam, Yoshihisa Kashima, Jennifer Tong, Victoria Yeung Dec 2010

Universal Biases In Self-Perception: Better And More Human Than Average, Steve Loughnan, Bernhard Leidner, Guy Doron, Nick Haslam, Yoshihisa Kashima, Jennifer Tong, Victoria Yeung

Research Collection School of Social Sciences

There is a well-established tendency for people to see themselves as better than average (self-enhancement), although the universality of this phenomenon is contested. Much less well-known is the tendency for people to see themselves as more human than average (self-humanizing). We examined these biases in six diverse nations: Australia, Germany, Israel, Japan, Singapore, and the USA. Both biases were found in all nations. The self-humanizing effect was obtained independent of self-enhancement, and was stronger than self-enhancement in two nations (Germany and Japan). Self-humanizing was not specific to Western or English-speaking cultures and its magnitude was less cross-culturally variable than self-enhancement. …

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The Role Of Dopamine In Resistance To Change Of Operant Behavior, Stacey L. Quick Dec 2010

The Role Of Dopamine In Resistance To Change Of Operant Behavior, Stacey L. Quick

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Psychological disorders such as autism, obsessive-compulsive disorder, drug addiction, and attention-deficit/hyperactivity disorder involve atypically persistent behavior and atypical activity of the neurotransmitter dopamine. Behavioral momentum theory states that the persistence of behavior in a context is determined by the reinforcement received previously in that context. Contexts previously associated with higher rates of reinforcement yield greater persistence of behavior than contexts previously associated with lower rates of reinforcement. According to a prominent hypothesis in behavioral neuroscience, dopamine mediates the incentive salience of a stimulus. A synthesis of behavioral momentum theory and the incentive salience hypothesis proposes similar roles for dopamine activity …

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Examining The Effectiveness And Efficiency Of Two Delivery Models To Teach Children Abduction Prevention Skills, Kimberly E. Seckinger-Bancroft Dec 2010

Examining The Effectiveness And Efficiency Of Two Delivery Models To Teach Children Abduction Prevention Skills, Kimberly E. Seckinger-Bancroft

Dissertations

Nearly all children receive abduction prevention training. Most traditional education programs increase the learner's knowledge, but often fail to produce concomitant behavior change. Behavioral Skills Training (BST) is a multicomponent, behavior-based training strategy with empirical support demonstrating its effectiveness in teaching children safety skills, behavioral generalization and maintenance over time. BST, however, is restricted by financial, human and time costs and limited resources to implement the training protocol. These factors likely limit widespread adoption of the training model. This study examined the use of computer-based instruction that emphasized active responding and mastery level performance requirements to teach school-aged children abduction …

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Predictors Of Recall And Reading Time For Seductive And Nonseductive Text Segments, Ivan V. Ivanov Dec 2010

Predictors Of Recall And Reading Time For Seductive And Nonseductive Text Segments, Ivan V. Ivanov

UNLV Theses, Dissertations, Professional Papers, and Capstones

This correlational study explored how concreteness, relevance, importance, and interestingness related to the recall of seductive details and base text, while controlling for text coherence, and student background knowledge. Previous research has provided evidence for the significant relationship between these variables and the seductive details effect in particular and text recall in general. However, this is the first study to consider all these variables simultaneously. A group of 68 undergraduates read an expository text on lightning formation, performed an immediate test on free recall, and rated each text sentence for concreteness, relevance, importance, and interestingness. A simple regression analysis revealed …

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Neurochemical Effects Of Amyloid-Beta Oligomers In Rats, John J. Panos Dec 2010

Neurochemical Effects Of Amyloid-Beta Oligomers In Rats, John J. Panos

Dissertations

Alzheimer’s disease is a progressive neurodegenerative disease characterized by memory loss and cognitive decline. Although the symptomology of Alzheimer’s disease is well defined, its precise etiology remains elusive. Animal models are invaluable for understanding the pathogenesis of this devastating disease. Knowledge of the neurochemical actions of amyloid-β oligomers in specific brain structures is essential for validating animal models of Alzheimer’s disease and for determining the most appropriate behavioral assays of memory. The specific aim of this project was to investigate the neurochemical effects of direct intracerebral infusion of amyloid-β oligomers in the rat. Experiment 1 investigated direct infusions of synthetic …

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Emotional Response To Auditory And Visual Stimuli, Amy Pitchforth Dec 2010

Emotional Response To Auditory And Visual Stimuli, Amy Pitchforth

Loma Linda University Electronic Theses, Dissertations & Projects

Emotion can be studied by measuring physiological, behavioral, and verbal responses to specific stimuli. In current research, it is most common to use visual stimuli to measure the emotional response. One of the most common sets of stimuli used for this purpose is the International Affective Picture Systems (IAPS). An additional set of stimuli, the International Affective Digital Sounds (IADS), was created to be an auditory equivalent of the IAPS. The present study sought to compare the emotional response (measured with Heart Rate, Skin Conductance, and a self-report measure of emotion called the SAM) to sounds from the IADS and …

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Worry And Rumination: Measurement Invariance Across Gender, Janet A. Carter Dec 2010

Worry And Rumination: Measurement Invariance Across Gender, Janet A. Carter

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

The present study examined the factor structure of the Penn State Worry Questionnaire (PSWQ), the Student Worry Questionnaire-30 (SWQ-30), the Anxious Thoughts Inventory (AnTI), the Ruminative Responses Scale (RRS), and the Rumination-Reflection Questionnaire (RRQ). The present study also examined the measurement invariance between men (n = 186) and women (n = 316) in a university sample. Different models for each measure were identified through a review of the literature, and the models were examined through confirmatory factor analyses. The best-fitting models for each measure were retained for subsequent model modification to improve fit and for invariance testing across …

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Correspondence Of Job-Preference And Job-Matching Assessment With Job Performance And Satisfaction Among Youth With Developmental Disabilities, Julie Hall Dec 2010

Correspondence Of Job-Preference And Job-Matching Assessment With Job Performance And Satisfaction Among Youth With Developmental Disabilities, Julie Hall

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

This study investigated the effects of job preference and job match on job performance among four 19-to 20-year-old young adults with developmental disabilities placed in community-based job conditions. Prior studies have examined the effects of job preference on community-based job performance without the job-matching component. The researcher identified high-preference, high-match and low-preference, low-match job conditions and tasks using a video web-based assessment program. Each participant was subsequently placed in a randomized sequence of 30-min sessions on one high-preference, high-match job condition performing a preferred task and one low-preference, low-match job performing a non preferred task. Job coaches instructed and prompted …

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Provide Visual Structure For Students With Asd, Tina Taylor Dec 2010

Provide Visual Structure For Students With Asd, Tina Taylor

Faculty Publications

World renowned animal scientist and autism self-advocate Temple Grandin said, "People on the autism/Asperger spectrum have uneven skills. They are often good at one type of learning and bad at another. Educators need to work on building up the area of strength." She explains that three cognitive areas of strength are those who are visual thinkers, pattern thinkers, and word thinkers. Visual thinkers are more inclined to think in pictures rather than words. They may excel in graphic design, industrial design, animation, geometry, or trigonometry. Pattern thinkers have abstract visual thoughts where they can see patterns and relationships between numbers. …

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A Psychometric Investigation Of The Young Adult Social Behavior Scale (Yasb), Michelle Rene Augustin Dec 2010

A Psychometric Investigation Of The Young Adult Social Behavior Scale (Yasb), Michelle Rene Augustin

Dissertations

Aggressive behavior is a serious public health concern that has resulted in several problems in contemporary society. Despite a considerable body of literature on human aggression, both popular and scientific, a focus on overt physical aggression has obscured other forms of aggression. As a result, considerably less is known about other, more subtle forms of aggression, such as relational aggression. Moreover, research on relational aggression, particularly among older adolescents and adults, has been hindered by the lack of psychometrically sound measures. Research in this area would be enhanced by the availability of such a measure, facilitating comparison of data across …

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Chronic Spontaneous Activity Generated In The Somata Of Primary Nociceptors Is Associated With Pain-Related Behavior After Spinal Cord Injury, Supinder S Bedi, Qing Yang, Robyn J Crook, Junhui Du, Zizhen Wu, Harvey M Fishman, Raymond J Grill, Susan M Carlton, Edgar T Walters Nov 2010

Chronic Spontaneous Activity Generated In The Somata Of Primary Nociceptors Is Associated With Pain-Related Behavior After Spinal Cord Injury, Supinder S Bedi, Qing Yang, Robyn J Crook, Junhui Du, Zizhen Wu, Harvey M Fishman, Raymond J Grill, Susan M Carlton, Edgar T Walters

Faculty, Staff and Student Publications

Mechanisms underlying chronic pain that develops after spinal cord injury (SCI) are incompletely understood. Most research on SCI pain mechanisms has focused on neuronal alterations within pain pathways at spinal and supraspinal levels associated with inflammation and glial activation. These events might also impact central processes of primary sensory neurons, triggering in nociceptors a hyperexcitable state and spontaneous activity (SA) that drive behavioral hypersensitivity and pain. SCI can sensitize peripheral fibers of nociceptors and promote peripheral SA, but whether these effects are driven by extrinsic alterations in surrounding tissue or are intrinsic to the nociceptor, and whether similar SA occurs …

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Reduction Of The Misinformation Effect By Arousal Induced After Learning, Shaun English, Kristy A. Nielson Nov 2010

Reduction Of The Misinformation Effect By Arousal Induced After Learning, Shaun English, Kristy A. Nielson

Psychology Faculty Research and Publications

Misinformation introduced after events have already occurred causes errors in later retrieval. Based on literature showing that arousal induced after learning enhances delayed retrieval, we investigated whether post-learning arousal can reduce the misinformation effect. 251 participants viewed four short film clips, each followed by a retention test, which for some participants included misinformation. Afterward, participants viewed another film clip that was either arousing or neutral. One week later, the arousal group recognized significantly more veridical details and endorsed significantly fewer misinformation items than the neutral group. The findings suggest that arousal induced after learning reduced source confusion, allowing participants to …

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Cognitive Impact Of Genetic Variation Of The Serotonin Transporter In Primates Is Associated With Differences In Brain Morphology Rather Than Serotonin Neurotransmission, Hank P. Jedema, Peter J. Gianaros, Phillip J. Greer, Dustin D. Kerr, Shijing Liu, James Dee Higley, Stephen J. Suomi, Adam S. Olsen, Jessica N. Porter, Brian J. Lopresti, Ahmad R. Hariri, Charles W. Bradberry Nov 2010

Cognitive Impact Of Genetic Variation Of The Serotonin Transporter In Primates Is Associated With Differences In Brain Morphology Rather Than Serotonin Neurotransmission, Hank P. Jedema, Peter J. Gianaros, Phillip J. Greer, Dustin D. Kerr, Shijing Liu, James Dee Higley, Stephen J. Suomi, Adam S. Olsen, Jessica N. Porter, Brian J. Lopresti, Ahmad R. Hariri, Charles W. Bradberry

Faculty Publications

A powerful convergence of genetics, neuroimaging and epidemiological research has identified biological pathways mediating individual differences in complex behavioral processes and related risk for disease. Orthologous genetic variation in non-human primates represents a unique opportunity to characterize the detailed molecular and cellular mechanisms which bias behaviorally- and clinically-relevant brain function. We report that a rhesus macaque orthologue of a common polymorphism of the serotonin transporter gene (rh5-HTTLPR) has strikingly similar effects on behavior and brain morphology to those in humans. Specifically, the rh5- HTTLPR Short allele broadly impacts cognitive choice behavior and brain morphology without observably affecting 5-HT transporter or …

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