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All Under Control: How Trait Emotional Intelligence May Moderate The Effect Of State Arousal On Implicit Attitudes Towards Academic Dishonesty, Daniel J. Moco Jan 2025

All Under Control: How Trait Emotional Intelligence May Moderate The Effect Of State Arousal On Implicit Attitudes Towards Academic Dishonesty, Daniel J. Moco

West Chester University Master’s Theses

The current study examined predictors in the changing of implicit attitudes toward academic dishonesty (AD). The primary predictor measured was self-reported stress and arousal, the strength of which being a possible influence on one’s change in implicit attitudes. Trait emotional intelligence (EI) was measured as a covariate and potential moderator of the interaction between stress and arousal, and one’s implicit attitudes toward AD. One hundred nine undergraduate psychology students from a public university were recruited to take assessments for trait EI, stress and arousal, and implicit attitudes toward AD. To manipulate the induction of stress and arousal, participants were randomly …


A Comparative Analysis Of Perineuronal Nets In Trout And Zebrafish Models, Adnan Alyan Jan 2025

A Comparative Analysis Of Perineuronal Nets In Trout And Zebrafish Models, Adnan Alyan

Cal Poly Humboldt theses and projects

Perineuronal nets (PNNs) are specialized extracellular matrix structures that surround certain types of neurons in the central nervous system. Research from the past few decades has cemented PNNs as an integral player in the closure and onset of critical periods, memory modulation, and neural plasticity. These effects are thought to occur when PNNs form around a neuron and structurally stabilize its synaptic connections. PNNs have been directly linked to behavioral changes, making them of interest to psychologists as well as neuroscientists. Several PNN components, such as Hapln1 and aggrecan such as have been found in zebrafish, a teleost fish (Kang …


Human Perception Of Ai Capabilities At Classifying Perturbed Roadway Signs, Katherine R. Garcia, Jing Chen, Yanru Xiao, Scott Mishler, Cong Wang, Bin Hu Jan 2025

Human Perception Of Ai Capabilities At Classifying Perturbed Roadway Signs, Katherine R. Garcia, Jing Chen, Yanru Xiao, Scott Mishler, Cong Wang, Bin Hu

Psychology Faculty Publications

Artificial Intelligence (AI) is crucial to numerous functions required for driving automation systems, including the computer vision techniques used to detect the roadway environment and make real-time decisions. However, the images used as inputs to the AI system may be maliciously perturbed, or manipulated, causing the AI system to make an incorrect classification. In this study, we examined humans’ perception of the AI’s computer vision capability of classifying various road sign images, including the original images, images with two different types of malicious attacks, and images that are scrambled randomly at the pixel level. Our results showed that participants rated …


Telling Their Story: A Proposed Social Group For Autistic Teenagers, Bailey Hull Jan 2025

Telling Their Story: A Proposed Social Group For Autistic Teenagers, Bailey Hull

Psychology Doctoral Specialization Projects

Typically developing adolescents go through many transitions and learning experiences from ages 13 to 18. Autistic adolescents also develop through these transitions and learning experiences. This unique group of adolescents can have a much more difficult time with these involvements, however, due to societal standards, learning, and growing within a neurodivergent mindset. As social isolation, bullying, and a lack of friendship opportunities continue to persist within the neurodivergent adolescent community, the lack of appropriate, affirming interventions must be addressed. This doctoral specialization project aims to provide licensed and student-level clinicians with a treatment manual to guide them through a social …


Acceptance And Commitment Therapy (Act) For Appalachains: Cultural Additions To Act, Jessica E. King Jan 2025

Acceptance And Commitment Therapy (Act) For Appalachains: Cultural Additions To Act, Jessica E. King

Psychology Doctoral Specialization Projects

This project examined the potential application of cultural additions to various aspects of Acceptance and Commitment Therapy (ACT). This project is specifically focused on cultural adaptations of ACT for the Appalachian population. The ACT adaptations were devised based on a review of research on Appalachian culture, including the region’s geography, history of exploitation, cultural values, and clinical considerations for working with Appalachian populations. An overview of ACT and treatment effectiveness of ACT is included. It is important to note that this project is intended to be a supplement to ACT, and should be used in tandem with an ACT workbook …


Measuring Personality And Animal Treatment Attitudes With The Pet Scale, Zackery J. Hilton Jan 2025

Measuring Personality And Animal Treatment Attitudes With The Pet Scale, Zackery J. Hilton

Honors Undergraduate Theses

Previous research has looked at the association between personality traits and the proclivity, or history, of committing acts that are characterized as animal abuse or animal cruelty. Much research has also found that individuals who exhibit this type of behavior towards animals also tend to exhibit similar behavior towards other individuals, mainly in the form of domestic or child abuse. Previous studies have measured animal abuse using very explicit and extreme criteria, using acts that are without question blatant abuse or torture; however, there is some grey area where many may argue whether certain acts should be considered abuse, which …


Finding Love On The Spectrum: An Analysis Of Social And Romantic Relationships Of Autistic College Students, Kaylee Spinner Jan 2025

Finding Love On The Spectrum: An Analysis Of Social And Romantic Relationships Of Autistic College Students, Kaylee Spinner

Masters Theses

Autism Spectrum Disorder (ASD) is characterized by difficulties in socialization, communication, and developing relationships with others. While many autistic individuals desire to start relationships with others, many do not have a very strong understanding of the use of nonverbal communication or how to develop these connections organically. As autistic individuals have become more open about wanting these resources to form social and romantic relationships, there has been more of a push in the literature to include social skills training for forming social relationships. However, the research on the desire for or development of romantic relationships for autistic individuals is still …


Assessing Electronic Nicotine Delivery System Abuse Liability Among People Who Smoke Cigarettes: Impact Of Device Characteristics, Nicotine Flux, And Flavor, Elizabeth Oluwapelumi Ogunleye Jan 2025

Assessing Electronic Nicotine Delivery System Abuse Liability Among People Who Smoke Cigarettes: Impact Of Device Characteristics, Nicotine Flux, And Flavor, Elizabeth Oluwapelumi Ogunleye

Theses and Dissertations

This clinical laboratory study utilizes subjective and behavioral economic measures to assess the abuse liability of own-brand cigarettes and six currently authorized ENDS products, examining how device characteristics, nicotine flux, and liquid flavor influence outcomes among adults who smoke cigarettes. Using a Latin-square-ordered, within-subject design, adults who smoke cigarettes (N = 30; N = 20 preferred menthol cigarettes) attended four clinical sessions: one to evaluate their own-brand cigarette and three to assess six NJOY ENDS products: 2.4% nicotine pods (~58 µg/s; tobacco and menthol flavor), 6% nicotine disposable products (~61-65 µg/s; tobacco and menthol flavor), and 5% nicotine pods (~118-123 …


Acute Effects Of Electronic Nicotine Delivery System Liquid Nicotine Form And Sweetener Among People Who Use Inhaled Tobacco Products, Mary A. Carrico Jan 2025

Acute Effects Of Electronic Nicotine Delivery System Liquid Nicotine Form And Sweetener Among People Who Use Inhaled Tobacco Products, Mary A. Carrico

Theses and Dissertations

Research on tobacco product standards to limit the abuse liability of electronic nicotine delivery systems (ENDS) has primarily focused on nicotine concentration and flavor. Other liquid characteristics, such as protonated nicotine ratio and sweetener additives, are less understood but may serve as regulatory targets. This clinical laboratory study examined the effects of ENDS protonated nicotine ratio and sweetener presence on nicotine delivery, use behavior, and subjective effects.

Thirteen participants completed four sessions that varied by protonated nicotine ratio (0:100 vs. 40:60 freebase to monoprotonated nicotine) and sweetener status (sweetened with 3 mg/mL ethyl maltol vs. unsweetened). Each session included a …


In Praise Of Dust, Hasler Gomez-Perez Jan 2025

In Praise Of Dust, Hasler Gomez-Perez

Theses and Dissertations

A desire path is a physical manifestation of where a system has failed, but also where it has been refused, where a new path has been made. The wake exists in the post, it is not a singular, untethered event, but a subtle double entendre that lives in the post-death, but also in the pre-life—not a liminal limbo, but a superposition of dying and waking.

This collection was assembled and composed over the course of two years as I navigated my practice, myself, and others. Present here are my thoughts, my experiences, and in many ways my beliefs. IN PRAISE …


Too Much Information: The Role Everyday Information Plays In The Understanding Of Mental Health, Jeremy M. Morgan Jan 2025

Too Much Information: The Role Everyday Information Plays In The Understanding Of Mental Health, Jeremy M. Morgan

Murray State Theses and Dissertations

Information overload has become increasingly problematic within the world of mental health, as people are able to go online and access overwhelming amounts of mental health-related information within seconds. The aim of the current study was to examine the interaction between excess mental health information and individuals’ understanding of mental health, specifically Autism Spectrum Disorder (ASD), as well as self-diagnosis. Data from 128 participants was examined. The data collected related to participants’ online search and use patterns of ASD information, their understanding of ASD symptoms, as well as their experiences with those symptoms. Results indicated a significant positive correlation between …


Identifying Intangible And Biocultural Heritage Elements Toward Environmental Understanding: Engaging Stakeholders Through Art, Martha B. Lerski Jan 2025

Identifying Intangible And Biocultural Heritage Elements Toward Environmental Understanding: Engaging Stakeholders Through Art, Martha B. Lerski

Publications and Research

Grounded in a case study in Barbuda in the Caribbean, this research examines sustainability from the perspective of what arts and heritage can contribute to community engagement and local and broader understandings about the environment. This article documents a growing body of literature recognizing the role of arts and culture, including local knowledge and traditional ecological knowledge (TEK), in climate change endeavors. Art and TEK present expansive world views. Contextual information situates research done on the island of Barbuda pre- and post-Hurricane Irma. Visual arts workshops engaged community members in mixed methods research. Results documented cultural elements, particularly intangible and …


Predicting 18-Month M-Chat-R/F With Pediatractmv3.0 Motor And Social/Communication/Cognition Domains, Ryan Krebs Jan 2025

Predicting 18-Month M-Chat-R/F With Pediatractmv3.0 Motor And Social/Communication/Cognition Domains, Ryan Krebs

Master's Theses and Doctoral Dissertations

Background. The developmental cascade framework suggests early delays in one system can impact others. Infants born preterm or with autism spectrum disorder (ASD) often show such delays. Methods. The study included 498 infants enrolled in PediaTracTM a novel caregiver-report measure. The convergent validity of PediaTrac with the Ages and Stages Questionnaire (ASQ-3) was examined, along with its ability to predict ASD risk at 18 months using cross-sectional (9- and 12-month) and longitudinal (0–12-month) latent traits of motor (MOT) and social/communication/cognitive (SCG) abilities. Results. Strong convergent validity was found between PediaTrac and ASQ-3 domains at both time points. MOT at 9-months …


What Is Success? How Peer Support Workers In Ontario See Addiction & Recovery, Ngaire Rasmussen Jan 2025

What Is Success? How Peer Support Workers In Ontario See Addiction & Recovery, Ngaire Rasmussen

Theses and Dissertations (Comprehensive)

The drug crisis in Canada has high mortality rates, especially in remote and rural communities, but there are significant barriers to accessing healthcare to which peer support may represent a partial solution, (Eddie et al., 2019; Englander et al., 2020; The Government of Canada, 2023; Kourgiantakis et al., 2023; Lavalley et al., 2020; Lennox et al., 202; Russell et al., 2021). Research how peer support workers define success in their work with adults experiencing addiction in Ontario, Canada is lacking, but important to understanding the crisis and implementing peer programs. Grounded in Marxist theory, the following exploratory research investigated the …


Human Perception Of Ai Capabilities At Classifying Perturbed Roadway Signs, Katherine R. Garcia, Jing Chen, Yanru Xiao, Scott Mishler, Cong Wang, Bin Hu Jan 2025

Human Perception Of Ai Capabilities At Classifying Perturbed Roadway Signs, Katherine R. Garcia, Jing Chen, Yanru Xiao, Scott Mishler, Cong Wang, Bin Hu

Computer Science Faculty Publications

Artificial Intelligence (AI) is crucial to numerous functions required for driving automation systems, including the computer vision techniques used to detect the roadway environment and make real-time decisions. However, the images used as inputs to the AI system may be maliciously perturbed, or manipulated, causing the AI system to make an incorrect classification. In this study, we examined humans’ perception of the AI’s computer vision capability of classifying various road sign images, including the original images, images with two different types of malicious attacks, and images that are scrambled randomly at the pixel level. Our results showed that participants rated …


Analysis Of Pre-Service Teachers’ Personal Metaphors About Foreign Language Teaching, Juan Luis De La Montaña Conchiña, Guadalupe De La Maya Retamar, Magdalena López-Pérez Jan 2025

Analysis Of Pre-Service Teachers’ Personal Metaphors About Foreign Language Teaching, Juan Luis De La Montaña Conchiña, Guadalupe De La Maya Retamar, Magdalena López-Pérez

Australian Journal of Teacher Education

This study analyses the characterisation and evolution of the personal metaphors of a sample of 34 trainee foreign language teachers, through a questionnaire of open-ended questions that included asking the participants to make drawings representing the roles of the teacher. Four categories of metaphors were considered for the analysis: behaviourist/transmissive, cognitivist/constructivist, situated, and self-referential. The results indicate that most participants were able to conceptualise their image of the teacher in the form of metaphors. The pre-service teachers’ metaphors represented are mainly cognitivist/constructivist and behaviourist/transmissive. When comparing them before and after the internship in the primary schools, most of them did …


A Bad Bet For Adolescents: Psychological Perspectives On Sports Betting & Digital Gambling Technologies, Kaitlyn Helfrich Jan 2025

A Bad Bet For Adolescents: Psychological Perspectives On Sports Betting & Digital Gambling Technologies, Kaitlyn Helfrich

CMC Senior Theses

Digital sports betting is a rapidly expanding sector of the gambling industry, allowing users to place wagers on the outcomes of sporting events from virtually anywhere. While structurally comparable to traditional gambling systems, sports betting is often perceived as a more socially acceptable and accessible alternative, contributing to its growing appeal and largely positive sentiment among Americans. Yet, in the seven years since sports betting has become legalized, growing numbers of Americans have reported psychological and financial problems stemming from problem gambling. Of particular concern is the increasing percentage of adolescents engaging with these platforms, despite legal restrictions on underage …


Hooked By Design: How Social Media Makes And Breaks Us, Anya Raghuvanshi Jan 2025

Hooked By Design: How Social Media Makes And Breaks Us, Anya Raghuvanshi

CMC Senior Theses

This thesis examines the evolving influence of social media platforms on user behavior, corporate engagement, and digital communication norms. Tracing the historical emergence of major platforms, it analyzes how psychological principles underlying attraction, engagement, and retention have been embedded within digital environments to shape user experiences. Drawing on case studies and international examples, the research highlights how cultural and economic factors — particularly in the United States — have influenced the adoption and monetization of social media. The study also explores broader shifts, including the rising commercialization of digital spaces and the evolving role of social media as both an …


Money Matters: Investigating The Emotional, Cognitive, And Biological Pathways Connecting Maternal Early Life Financial Insecurity And Parenting Quality, Elise Power, Stacey N. Doan Jan 2025

Money Matters: Investigating The Emotional, Cognitive, And Biological Pathways Connecting Maternal Early Life Financial Insecurity And Parenting Quality, Elise Power, Stacey N. Doan

CMC Senior Theses

Early life adversity has been shown to have a variety of negative effects on adult functioning, including parenting quality, with implications for child wellbeing. Adverse early life experiences including poverty have been linked to long-term disruptions in emotional, cognitive, and physiological functioning that compromise the ability to provide sensitive, nurturing care. The present study investigated whether emotional regulation difficulties, physiological regulation, and cognitive function mediate the relationship between early life financial insecurity and parenting quality. A sample of 132 mother-child dyads completed self-report measures, biological samples, and cognitive assessments. A multiple mediation model ran in SPSS, revealed a significant indirect …


Severe Aggression Among Zoo-Housed Coconut (Trichoglossus Haematodus) And Rainbow (Trichoglossus Moluccanus) Lorikeets: Wellbeing Considerations For Free-Flight Aviaries, Emily Simkins Jan 2025

Severe Aggression Among Zoo-Housed Coconut (Trichoglossus Haematodus) And Rainbow (Trichoglossus Moluccanus) Lorikeets: Wellbeing Considerations For Free-Flight Aviaries, Emily Simkins

UNF Graduate Theses and Dissertations

As conservation and education institutions, modern zoos balance the needs of animals with the interests of visitors through several strategies which can increase animal wellbeing and improve visitor experience. Environmental enrichment is frequently employed to increase the suitability of anthropogenic environments for zoo-housed animals, such as through walkthrough habitats and free-flight aviaries. While habitats such as these are important for visitor experience and can be enriching to animals, there are also wellbeing considerations for these spaces. Walkthrough habitats can be a potential source of fear and stress for animals, as shown by increased frequencies of vigilance, undesirable behavior, and aggression. …


Fortifying Nuclear Security: Cultivating Vigilance Culture Among Personnel For Enhanced Prevention And Response, Sabariah Kader Ibrahim, Sonia Naz Jan 2025

Fortifying Nuclear Security: Cultivating Vigilance Culture Among Personnel For Enhanced Prevention And Response, Sabariah Kader Ibrahim, Sonia Naz

International Journal of Nuclear Security

A vigorous nuclear security culture is crucial in preventing the theft and sabotage of nuclear material. It requires vigilance from all employees because relying solely on closed-circuit television systems and security personnel is insufficient to deter potential threats. Employee attentiveness plays a vital role in recognizing and preventing suspicious activities. However, achieving a strong security culture is challenging because of the lack of incidents in some facilities, leading to employee complacency.

This paper highlights the pivotal role of personnel in the success of nuclear security measures, emphasizing the need for a proactive and vigilant mindset among staff. Through the analysis …


Renewal Of Cocaine Seeking Using Social And Nonsocial Contextual Stimuli, Bree A. Humburg, Michael T. Bardo Jan 2025

Renewal Of Cocaine Seeking Using Social And Nonsocial Contextual Stimuli, Bree A. Humburg, Michael T. Bardo

Psychology Faculty Publications

Rationale Various nonsocial cues have been used as stimuli to examine the contextual control of drug seeking behavior, but little is known about the role of social stimuli.

Objectives This study determined if renewal of cocaine seeking is differentially controlled using a context consisting of either a social peer and/or house light illumination.

Methods In Experiment 1, male and female rats trained to self-administer cocaine in the presence of a same-sex social peer and house light illumination (context A). Following self-administration, rats were randomly assigned to either an AAA (control) or ABA (renewal) group for extinction. For AAA rats, extinction …


An Exploratory Approach To Understanding Assessment Errors On Measures Of Executive Functioning, Gurjot Mondair Jan 2025

An Exploratory Approach To Understanding Assessment Errors On Measures Of Executive Functioning, Gurjot Mondair

PCOM Psychology Dissertations

The global risk of dementia due to longer lifespans and increased medical interventions necessitates accurate diagnosis of cognitive decline. Thus, the utilization of neuropsychological testing to diagnose disorders of cognitive decline should seek to ascertain multiple data, including success/failure of cognitive tasks and evaluation of error patterns. The purpose of this study was to examine the frequency of executive function (EF) errors across diagnoses of cognitive decline (age-related cognitive decline [ARCD], mild cognitive impairment [MCI], vascular dementia [VaD], frontotemporal dementia [FTD], Lewy body dementia [LBD], and Alzheimer’s disease [AD]) and to examine whether the specific types of EF errors (intrusion, …


Examining Factors Considered In Autism Specialization Among Early Career Psychologists, Tarie Taylor Jan 2025

Examining Factors Considered In Autism Specialization Among Early Career Psychologists, Tarie Taylor

PCOM Psychology Dissertations

Families in the United States often face significant delays in accessing autism-related healthcare services. Despite routine autism-specific screenings at 18- and 24-month pediatric visits, there is still, on average, a gap of over two years before families receive an autism diagnosis (Chen et al., 2023). Although the literature cites factors like limited access to specialized providers and a lack of autism-specific services contributing to this delay (Cantor et al., 2020), further research is needed to explore the underlying factors influencing providers' decisions to specialize in an autism-related healthcare service. Thus, the current study used a mixed-methods, internet-based survey to examine …


Examining Executive Functions And Semantic Organization Across Occupation Types, Emily Murtha Jan 2025

Examining Executive Functions And Semantic Organization Across Occupation Types, Emily Murtha

PCOM Psychology Dissertations

This study examined the relationship between executive functioning, semantic organization, and occupational classification, focusing on whether individuals in professional roles (as defined by the Career Occupational Preference System; COPS) demonstrated stronger executive functioning and semantic organization during memory recall than those in non-professional roles. Participants completed the Booklet Category Test (BCT) to assess executive functioning, the California Verbal Learning Test–Second Edition (CVLT-II) to evaluate semantic organization using short-delay free recall (SDFR), and the Wechsler Adult Intelligence Scale–Fourth Edition (WAIS-IV) to measure IQ. Results showed no significant associations among the main variables. While higher BCT performance was linked to greater use …


Sex-Dependent Changes In Risk-Taking Predisposition Of Rats Following Space Radiation Exposure, Elliot Smits, Faith E. Reid, Ella N. Tamgue, Paola Alvarado Arriaga, Charles Nguyen, Richard A. Britten Jan 2025

Sex-Dependent Changes In Risk-Taking Predisposition Of Rats Following Space Radiation Exposure, Elliot Smits, Faith E. Reid, Ella N. Tamgue, Paola Alvarado Arriaga, Charles Nguyen, Richard A. Britten

Department Radiation Oncology & Biophysics Faculty Publications

The Artemis missions will establish a sustainable human presence on the Moon, serving as a crucial steppingstone for future Mars exploration. Astronauts on these ambitious missions will have to successfully complete complex tasks, which will frequently involve rapid and effective decision making under unfamiliar or high-pressure conditions. Exposure to low doses of space radiation (SR) can impair key executive functions critical to decision making. This study examined the effects of exposure to 10 cGy of Galactic Cosmic Ray simulated radiation (GCRsim) on decision-making performance in male and female rats with a naturally low predisposition for risk-taking (RTP) prior to exposure. …


A Two-Hit Model Of Executive Dysfunction: Simulated Galactic Cosmic Radiation Primes Latent Deficits Revealed By Sleep Fragmentation, Richard A. Britten, Ella N. Tamgue, Paola Arriaga Alvarado, Arriyam S. Fesshaye, Larry D. Sanford Jan 2025

A Two-Hit Model Of Executive Dysfunction: Simulated Galactic Cosmic Radiation Primes Latent Deficits Revealed By Sleep Fragmentation, Richard A. Britten, Ella N. Tamgue, Paola Arriaga Alvarado, Arriyam S. Fesshaye, Larry D. Sanford

Department Radiation Oncology & Biophysics Faculty Publications

Future Artemis-class missions to Mars will expose astronauts to prolonged space radiation (SR), sleep disruption, and operational demands requiring greater autonomy, placing decision making and executive function at heightened risk. Both SR and sleep fragmentation (SF) independently impair cognition, yet their combined effects remain poorly understood. Using the Associative Recognition Memory and Interference (ARMIT) task, we assessed cognitive performance in male rats exposed to 10 cGy of Galactic Cosmic Ray simulation (GCRsim), SF, or both. Under well-rested conditions, GCRsim-exposed rats exhibited overt deficits in the C.1.2 stage, performing at chance when reinforcement contingencies shifted, consistent with impaired cognitive flexibility. In …


Cleansing Our Recycling Failures: How Guilt And Outrage Lead To Different Types Of Pro-Environmental Behavior, Cody D. Packard Jan 2025

Cleansing Our Recycling Failures: How Guilt And Outrage Lead To Different Types Of Pro-Environmental Behavior, Cody D. Packard

CGU Theses & Dissertations

Most Americans view recycling as “the right thing to do,” yet U.S. recycling rates lag behind other developed countries, and Americans are quick to justify why they do not recycle more (e.g., laziness, inconvenience). Recent messaging has highlighted recycling failures in the U.S., but how effective are these messages, and do they create individual behavioral changes? According to research on moral self-regulation, failing to act morally can threaten a person’s moral self-concept, eliciting moral emotions (i.e., guilt and outrage), and motivating compensatory behavior (such as increased recycling). Three studies examined whether watching a video about poor recycling in the U.S. …


Traditional And Non-Traditional Behavioral Tests Demonstrate The Attenuation Of Cognitive Deficits By Therapeutic Hypothermia In A Rat Model Of Neonatal Hypoxic-Ischemic Encephalopathy, Angela Saadat, Cortney Kaszowski, Haree Pallera, Frank Lattanzio, Richard A. Britten, Asna Sulaiman, Stephanie Newman, Alireza Hosseini, Tushar Shah Jan 2025

Traditional And Non-Traditional Behavioral Tests Demonstrate The Attenuation Of Cognitive Deficits By Therapeutic Hypothermia In A Rat Model Of Neonatal Hypoxic-Ischemic Encephalopathy, Angela Saadat, Cortney Kaszowski, Haree Pallera, Frank Lattanzio, Richard A. Britten, Asna Sulaiman, Stephanie Newman, Alireza Hosseini, Tushar Shah

Department of Pediatrics Faculty Publications

Introduction: Neonatal hypoxic-ischemic encephalopathy (HIE) is neurological disease caused by the deprivation of oxygen and blood flow to the brain during the developmentally-critical perinatal period. Therapeutic hypothermia (TH) is the standard of care treatment for HIE, though cognitive deficits can persistent throughout life despite treatment. The nature of these deficits, and the impacts of TH and sex are not well understood, and this presents a key barrier in the development of novel therapeutics.

Methods: The goal of this study was to enhance the characterization and measurement of cognitive outcomes with tasks that measure spontaneous behaviors in a rodent models of …


A Decision-Space Model Explains Context-Specific Decision Making, Dirk W. Beck, Cory N. Heaton, Luis D. Davila, Lara I. Rakocevic, Sabrina M. Drammis, Danil Tyulmankov, Atanu Giri, Shreeya Umashankar Beck, Qingyang Zhang, Michael Pokojovy, Kenichiro Negishi, Alexis A. Salcido, Neftali F. Reyes, Andrea Y. Macias, Serina A. Batson, Paulina Vara, Raquel J. Ibáñez Alcalá, Safa B. Hossain, Graham L. Waller, Laura E. O'Dell, Travis M. Moschak, Ki A. Goosens, Alexander Friedman Jan 2025

A Decision-Space Model Explains Context-Specific Decision Making, Dirk W. Beck, Cory N. Heaton, Luis D. Davila, Lara I. Rakocevic, Sabrina M. Drammis, Danil Tyulmankov, Atanu Giri, Shreeya Umashankar Beck, Qingyang Zhang, Michael Pokojovy, Kenichiro Negishi, Alexis A. Salcido, Neftali F. Reyes, Andrea Y. Macias, Serina A. Batson, Paulina Vara, Raquel J. Ibáñez Alcalá, Safa B. Hossain, Graham L. Waller, Laura E. O'Dell, Travis M. Moschak, Ki A. Goosens, Alexander Friedman

Mathematics & Statistics Faculty Publications

Optimal decision-making requires consideration of internal and external contexts. Biased decision-making is a transdiagnostic symptom of neuropsychiatric disorders. We created a computational model demonstrating how the striosome compartment of the striatum constructs a context-dependent mathematical space for decision-making computations, and how the matrix compartment uses this space to define action value. The model explains multiple experimental results and unifies other theories like reward prediction error, roles of the direct versus indirect pathways, and roles of the striosome versus matrix, under one framework. We also found, through new analyses, that striosome and matrix neurons increase their synchrony during difficult tasks, caused …