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An Evaluation Of Traditional And Non-Traditional Psychopharmacological Treatments For Major Depression, Makayla Sanchez Apr 2018

An Evaluation Of Traditional And Non-Traditional Psychopharmacological Treatments For Major Depression, Makayla Sanchez

Honors Projects

Depression is one of the most prevalent mental illnesses within society today, with overarching effects in the social, personal, and professional lives of millions of individuals who are suffering. The typical treatment for major depression is often a prescription of an antidepressant, either exclusively or combined with another form of treatment, such as psychotherapy. The intended effect is to increase levels of neurotransmitters such as serotonin and dopamine within the brain to regulate mood and emotion. While this treatment is effective for some patients, not all find relief. Exploring and extending research into other substances that effect the 5-hydroxytryptamine (5-HT) …


Further Development Of A Supervision System For Behavior Analysts To Support Evidence-Based Supervision Practices, Katie Lynn Garza Apr 2018

Further Development Of A Supervision System For Behavior Analysts To Support Evidence-Based Supervision Practices, Katie Lynn Garza

Dissertations

Effective supervision for individuals seeking certification from the Behavior Analyst Certification Board® (BACB) has been a recent focus in the field of behavior analysis (BACB, 2012). While the organizational behavior management (OBM) literature is rich with evidence for specific performance-improvement techniques, there is a lack of research on supervision systems specifically for supervising individuals seeking to obtain the Board Certified Behavior Analyst (BCBA) credential. Furthermore, studies to date have not examined what it takes for systems to meet their missional objectives while simultaneously providing training and supervision to trainees. This descriptive, process-oriented study sought to analyze the disconnects within a …


Teaching Eye Contact And Responding To Name To Children With Autism Spectrum Disorder, Amelia M. Fonger Apr 2018

Teaching Eye Contact And Responding To Name To Children With Autism Spectrum Disorder, Amelia M. Fonger

Dissertations

Eye contact and responding to name may be described as behavioral cusps because acquiring these skills extends contact with the environment, can allow behavior to come under the control of new contingencies, and may facilitate the acquisition of new behavior (Bloom & Lahey, 1978; Carbone, O’Brien, Sweeney-Kerwin, & Albert, 2013; Cook et al., 2017; Hanley, Heal, Tiger, & Ingvarsson, 2007; Rosales-Ruiz & Baer, 1997; Tiegerman & Primavera, 1984; Weiss & Zane, 2010). Eye contact and responding to name are commonly cited as targets for early intensive behavioral intervention; however, the existing literature is limited in its ability to guide a …


Investigating Generalization Of Motorist Yielding To The Gateway Prompt From The Treated Leg Of The Intersection To The Untreated Adjacent Leg, Brian J. Crowley-Koch Apr 2018

Investigating Generalization Of Motorist Yielding To The Gateway Prompt From The Treated Leg Of The Intersection To The Untreated Adjacent Leg, Brian J. Crowley-Koch

Dissertations

Pedestrian safety continues to be an important research topic, especially since recent data show a small increase in pedestrian fatalities (USGAO, 2015). There have been several interventions that prompt pedestrians, but especially motorists, to yield properly at uncontrolled crosswalks (Van Houten, 1988; Van Houten & Malenfant, 1992; Nasar, 2003; Crowley-Koch, Van Houten & Lim, 2008). One low-cost intervention that has been successful is the R1-6 in road yielding sign (Kannel, Souleyrette, & Tenges, 2003). When this sign is laid out purposefully across a crosswalk (called a gateway), it has resulted in substantial increases in yielding compared to baseline conditions. In …


Chronic Administration Of Probiotic L. Rhamnosus Increases Anxiety-Like Behavior In Group-Housed Male Long Evans Rats, Parker Maddison Griff Apr 2018

Chronic Administration Of Probiotic L. Rhamnosus Increases Anxiety-Like Behavior In Group-Housed Male Long Evans Rats, Parker Maddison Griff

Honors Theses

Early life stress is a risk factor for later development of alcohol use disorders and anxiety disorders in humans. Using rodent experimental models, we know that rats experiencing social isolation as early-life stress exhibit greater anxiety-like behavior and alcohol consumption than rats housed in groups. Examining potential preventive strategies, we investigated the effects of probiotics, which have previously been shown to decrease rodent anxiety-like behavior, on the relationship between early-life stress and anxiety-like behavior in rats. We hypothesized that probiotics consumption would decrease anxiety-like behavior in socially isolated rats, as well as in rats housed in groups. To our surprise, …


The Effects Of Adolescent Housing Condition And Voluntary Exercise On Alcohol Intake And Stress Response In Male Long-Evans Rats, Caroline Lynch Apr 2018

The Effects Of Adolescent Housing Condition And Voluntary Exercise On Alcohol Intake And Stress Response In Male Long-Evans Rats, Caroline Lynch

Honors Theses

Can regular exercise during adolescence, combined with living in a social environment, decrease the negative effects of chronic stress and lower alcohol intake later in life? The aim of this research is to answer this question using a rat model that introduces a novel behavioral intervention in the form of regular voluntary exercise in order to counteract the negative effects of chronic stress caused by socially isolated housing during adolescence. Chronic stress has been linked to the development of alcohol use disorders (AUDs) in humans, and this study attempts to both model and hamper this phenomenon in rats using voluntary …


Alcohol Deprivation Effect: An Investigation Of A Model Of Alcohol Dependence And Relapse Behaviors In Male And Female Long Evans Rats, Hanna J. Peterson Apr 2018

Alcohol Deprivation Effect: An Investigation Of A Model Of Alcohol Dependence And Relapse Behaviors In Male And Female Long Evans Rats, Hanna J. Peterson

Honors Theses

The purpose of this study was to understand relapse behavior through a pre-clinical rodent model of relapse which models the important aspects of the human addiction and relapse condition, called the alcohol deprivation effect (ADE) model. It has been found to model alcohol addiction and relapse in rats and can therefore allow for further understanding of relapse behavior as well as allow for testing of the effects of various variables like stress or therapeutic drugs on relapse behavior. The model gives rats baseline access to ethanol and then allows them access to only water, called deprivation periods, and then gives …


Mind, Rationality, And Cognition: An Interdisciplinary Debate, N. Chater, T. Felin, D. C. Funder, G. Gigerenzer, J. J. Koenderink, J. I. Krueger, D. Noble, S. A. Nordli, M. Oaksford, Barry Schwartz, K. E. Stanovich, P. M. Todd Apr 2018

Mind, Rationality, And Cognition: An Interdisciplinary Debate, N. Chater, T. Felin, D. C. Funder, G. Gigerenzer, J. J. Koenderink, J. I. Krueger, D. Noble, S. A. Nordli, M. Oaksford, Barry Schwartz, K. E. Stanovich, P. M. Todd

Psychology Faculty Works

This article features an interdisciplinary debate and dialogue about the nature of mind, perception, and rationality. Scholars from a range of disciplines—cognitive science, applied and experimental psychology, behavioral economics, and biology—offer critiques and commentaries of a target article by Felin, Koenderink, and Krueger (2017): “Rationality, Perception, and the All-Seeing Eye,” Psychonomic Bulletin & Review. The commentaries raise a number of criticisms and issues concerning rationality and the all-seeing-eye argument, including the nature of judgment and reasoning, biases versus heuristics, organism–environment relations, perception and situational construal, equilibrium analysis in economics, efficient markets, and the nature of empirical observation and the scientific …


Sacrificial Dynamite: The Convergence Of Developed Empathy And Ongoing Relational Experience With God: A Grounded Theory, Toran Scott Apr 2018

Sacrificial Dynamite: The Convergence Of Developed Empathy And Ongoing Relational Experience With God: A Grounded Theory, Toran Scott

Dissertations

This grounded theory study examined how participants described and reflected on their lives and what led them to choose sacrifice. The study was grounded in a Christian understanding of sacrifice, defined as the willful giving up of one’s positions or possessions for the sake of serving others. Using in-depth, open-ended interviews and follow-up interviews to co-construct meaning, participants were asked to reflect on their childhood, adolescence, and emerging adulthood to reflect on and describe any messages, relationships, or experiences that they thought contributed to their eventual choice to sacrifice. The interviews were free-flowing and filled with beautiful and engaging stories. …


Abnormal Perceptual Sensitivity In Body-Focused Repetitive Behaviors, David C. Houghton, Jennifer R. Alexander, Christopher C. Bauer, Douglas W. Woods Apr 2018

Abnormal Perceptual Sensitivity In Body-Focused Repetitive Behaviors, David C. Houghton, Jennifer R. Alexander, Christopher C. Bauer, Douglas W. Woods

Psychology Faculty Research and Publications

Objective

Several compulsive grooming habits such as hair pulling, skin picking, and nail biting are collectively known as body-focused repetitive behaviors (BFRBs). Although subclinical BFRBs are common and benign, more severe and damaging manifestations exist that are difficult to manage. Researchers have suggested that BFRBs are maintained by various cognitive, affective, and sensory contingencies. Although the involvement of cognitive and affective processes in BFRBs has been studied, there is a paucity of research on sensory processes.

Methods

The current study tested whether adults with subclinical or clinical BFRBs would report abnormal patterns of sensory processing as compared to a healthy …


A Multi-Dimensional Model Of Enjoyment: Development And Validation Of An Enjoyment Scale (Enjoy), Shayn Davidson Apr 2018

A Multi-Dimensional Model Of Enjoyment: Development And Validation Of An Enjoyment Scale (Enjoy), Shayn Davidson

Doctoral Dissertations and Master's Theses

Enjoyment of an activity is central to positive experiences and can determine future behavior toward the activity or object of interest. In the literature there has been no consensus on the definition and dimensionality of enjoyment. In this dissertation, to provide clarity to the construct, a new multi-dimensional model and definition of enjoyment is proposed. To investigate enjoyment, a new measure of enjoyment applicable to any activity was developed using current best practices of scale development and validation.

The new instrument measures enjoyment of any activity, called the ENJOY scale. The ENJOY scale has 5 subscales and demonstrated good content …


Screening For Traumatic Brain Injury In Prostituted Women, Melissa Farley, Martha E. Banks, Rosalie J. Ackerman, Jacqueline M. Golding Apr 2018

Screening For Traumatic Brain Injury In Prostituted Women, Melissa Farley, Martha E. Banks, Rosalie J. Ackerman, Jacqueline M. Golding

Dignity: A Journal of Analysis of Exploitation and Violence

Violence is pervasive in prostitution and can cause traumatic brain injury (TBI). This study estimated the prevalence and demographic correlates of TBI among 66 women and transwomen in prostitution. Ninety-five percent had sustained head injuries, either by being hit in the head with objects and/or having their heads slammed into objects. Sixty-one percent had sustained head injuries in prostitution. The women described acute and chronic symptoms resulting from head injury and/or concussions. These included dizziness, depressed mood, headache, sleep difficulty, poor concentration, memory problems, difficulty following directions, low frustration tolerance, fatigue, and appetite and weight changes. Screening for TBI is …


The Personality Profile Of North Korean Supreme Leader Kim Jong Un, Aubrey Immelman Apr 2018

The Personality Profile Of North Korean Supreme Leader Kim Jong Un, Aubrey Immelman

Psychology Faculty Publications

This paper presents the results of an indirect assessment of the personality of Kim Jong-un, supreme leader of the Democratic People’s Republic of Korea, conducted 2013–2018 from the conceptual perspective of personologist Theodore Millon.

Psychodiagnostically relevant data about Kim was collected from open-source media reports and synthesized into a personality profile using the Millon Inventory of Diagnostic Criteria (MIDC), which yields 34 normal and maladaptive personality classifications congruent with DSM–III–R, DSM–IV, and DSM–5.

The personality profile yielded by the MIDC was analyzed in accordance with interpretive guidelines provided in the MIDC and Millon Index of Personality Styles …


Assessing Personality Dynamics In Personnel Selection, Joanna Sosnowska, Joeri Hofmans, Filip Lievens Apr 2018

Assessing Personality Dynamics In Personnel Selection, Joanna Sosnowska, Joeri Hofmans, Filip Lievens

Research Collection Lee Kong Chian School Of Business

Recently, there have been repeated calls in the literature for an integrative approach to personality, in which both between- and within-person fluctuations are simultaneously considered. Although the integrative approach to personality offers a compelling extension of the traditional trait approach, one of the major challenges is its applicability in applied settings. In the present chapter, we address this challenge for the domain of personnel selection, showing that an integrative approach to personality assessment in selection settings is possible through careful consideration of available theories and selection methods. By explaining and delineating how existing concepts can be used and how existing …


Developmental Changes In Corticotropin Releasing Factor Receptor 1 In The Postnatal Dentate Gyrus, Danielle Fico Apr 2018

Developmental Changes In Corticotropin Releasing Factor Receptor 1 In The Postnatal Dentate Gyrus, Danielle Fico

Psychology

Corticotropin releasing factor (CRF) has been established as a key modulator in the stress response. Areas of research have primarily focused on brain regions that control the hypothalamic-pituitary-adrenal (HPA) axis. However, extensive research has yet to be conducted on the CRF receptor 1 (CRFR1) in the dentate gyrus, a region associated with memory functions. Therefore, the purpose of this study is to investigate age-related changes in CRFR1 in the granule layer and the hilus layer of the dentate gyrus in CRFR1 reporter mice at three different age groups; pre-pubertal (p21), adult (p90), and old (22-24 months) age. The results of …


The Effects Of Acute Stress On Emotion Recognition Of Bodily Movements, Devi Jayan Apr 2018

The Effects Of Acute Stress On Emotion Recognition Of Bodily Movements, Devi Jayan

Master's Theses (2009 -)

Lack of understanding of the mental state of others may govern poor social interactions and, the etiology and maintenance of several mental health conditions. In everyday situations, verbal and non-verbal affective stimuli are often processed under conditions of acute stress. Acute stress is associated with changes in cognition, affect, behavior and neural functioning; however, previous research has not sufficiently identified the role of acute stress on emotion recognition (ER) from body movements. The current study explored the effects of acute stress and related physiological responses on ER of dynamic body movements. Eighty-Four participants were exposed to an acute stress procedure …


Increasing Employee-Guest Interactions Using A Guest-Delivered Token Economy At A Zoological Facility, Cassie Maureen Vergason Apr 2018

Increasing Employee-Guest Interactions Using A Guest-Delivered Token Economy At A Zoological Facility, Cassie Maureen Vergason

Theses and Dissertations

Token economies have been used for many years to improve a multitude of behaviors in a variety of settings. However, research on token economies as an intervention to improve customer service-related behaviors of employees in organizations is limited. The current study assessed this issue by evaluating a guest-delivered token economy to improve employee-guest interactions at a zoological facility. Results showed increases of 35.3% and 45.0% in correct employee-guest interactions in each intervention phase compared to baseline, thus suggesting that a guest-delivered token economy is an effective way to improve customer service (guest interactions)-related behaviors. Limitations of the current study and …


The Effects Of Rhythm For Social Emotional Learning Skills Development, Jonathan O. Mande Mar 2018

The Effects Of Rhythm For Social Emotional Learning Skills Development, Jonathan O. Mande

Lesley University Community of Scholars Day

Many people talk about the importance of music in school and learning, we all know about its effects on cognitive development for children and adults. Though despite these universally known facts, music education programs are increasingly underfunded in schools, private lessons are not accessible to most people, while our country is simultaneously suffering from an increase in academic retention and destructive societal conflicts. Music brings all people together and at its core is rhythm. It makes available a space for joy; to fully express love, build bonds and strengthen our individual spirits. When used intentionally, music heals and is a …


School Counselors' Role In Reducing Aggression In Children In Alternative Education Programs, Deirdra Sanders-Burnett Mar 2018

School Counselors' Role In Reducing Aggression In Children In Alternative Education Programs, Deirdra Sanders-Burnett

USF Tampa Graduate Theses and Dissertations

Despite efforts to reduce the occurrence of physical aggression in traditional school environments, some students persist in engaging in physical aggression and are assigned to alternative education programs as an alternative to expulsion. However, relatively little is known about the types of services that school counselors provide to help these students. This case study investigated the services that school counselors provide to the young children attending disciplinary alternative education programs in a public-school district in central Florida. The participants consist of two school counselors who provided services to the students assigned to the alternative disciplinary programs and two district-level administrators …


Better Safe Than Sorry: The Relationship Between Locus Of Control, Perception Of Risk, And Cyber Misbehaviors, Kim Johnson Mar 2018

Better Safe Than Sorry: The Relationship Between Locus Of Control, Perception Of Risk, And Cyber Misbehaviors, Kim Johnson

USF Tampa Graduate Theses and Dissertations

Information security is of vital importance to organizations. Breaches in security very often stem from behaviors of the system operator. Cyber misbehaviors on the part of employees can have devastating repercussions on the well-being of an organization. Up to now, research has mainly focused on how to protect information systems from outside attack, and only recently have researchers turned to the part the operator plays in keeping the systems safe. The present study investigated some individual differences that may play a role in people’s cyber behavior. The purpose of the study was to determine if locus of control was related …


Motivational Valence Alters Memory Formation Without Altering Exploration Of A Real-Life Spatial Environment, Kimberly S. Chiew, Jordan Hashemi, Lee K. Gans, Laura Lerebours, Nathaniel J. Clement, Mai-Anh T. Vu, Guillermo Sapiro, Nicole E. Heller, R. Alison Adcock Mar 2018

Motivational Valence Alters Memory Formation Without Altering Exploration Of A Real-Life Spatial Environment, Kimberly S. Chiew, Jordan Hashemi, Lee K. Gans, Laura Lerebours, Nathaniel J. Clement, Mai-Anh T. Vu, Guillermo Sapiro, Nicole E. Heller, R. Alison Adcock

Psychology: Faculty Scholarship

Volitional exploration and learning are key to adaptive behavior, yet their characterization remains a complex problem for cognitive science. Exploration has been posited as a mechanism by which motivation promotes memory, but this relationship is not well-understood, in part because novel stimuli that motivate exploration also reliably elicit changes in neuromodulatory brain systems that directly alter memory formation, via effects on neural plasticity. To deconfound interrelationships between motivation, exploration, and memory formation we manipulated motivational state prior to entering a spatial context, measured exploratory responses to the context and novel stimuli within it, and then examined motivation and exploration as …


Variation In Emotion Eliciting Events And Display Rules As A Function Of Individualism And Collectivism: A Cross Cultural Comparison Of Pakistanis And Americans, Serah Saleem Fatani Mar 2018

Variation In Emotion Eliciting Events And Display Rules As A Function Of Individualism And Collectivism: A Cross Cultural Comparison Of Pakistanis And Americans, Serah Saleem Fatani

College of Science and Health Theses and Dissertations

Culture not only influences the conditions under which we will experience an emotion, but also may have bearing on its manner of outward expression. This study investigated cultural differences in the construction of emotion-eliciting events and the associated display rules for exhibiting those emotional responses to others within the context of the cultural classification system known as Individualism/Collectivism (I/C) (Triandis, 1994, 1995; Triandis et al., 1988). In this comparative study, individualists were represented by a sample of participants from the United States whereas collectivists were represented by a Pakistani participant sample.

I/C tendencies of the Pakistani and American respondents were …


A Clean, Green New Zealand? An In-Depth Look At The Personal Experiences Of Animal Rights Activists, Svetlana Feigin, Richard Glynn Owens, Felicity Goodyear-Smith Mar 2018

A Clean, Green New Zealand? An In-Depth Look At The Personal Experiences Of Animal Rights Activists, Svetlana Feigin, Richard Glynn Owens, Felicity Goodyear-Smith

The Qualitative Report

This study explored personal experiences of animal rights and environmental activists in New Zealand. The stories of participants provided insight into the challenges activists face in a country where the economy is heavily dependent on animal agriculture. A qualitative methodology was utilised and several major themes emerged: (1) emotional and psychological experiences, (2) group membership, (3) characteristics of activism and liberation, (4) the law and its agents, and (5) challenge to society. Participants of the study represent a group of individuals engaged in acts of altruistic offending triggered by exposure to the suffering of non-human animals. Their moral philosophy and …


The Human 'As-If'-Function And Its Loss In Schizophrenia, Thomas Fuchs Mar 2018

The Human 'As-If'-Function And Its Loss In Schizophrenia, Thomas Fuchs

Phenomenology Center Annual Symposium

No abstract provided.


Narrative Leadership: Exploring The Concept Of Time In Leader Storytelling, Helen H. Chung Dr. Mar 2018

Narrative Leadership: Exploring The Concept Of Time In Leader Storytelling, Helen H. Chung Dr.

Industrial-Organizational Psychology Dissertations

This dissertation explores leader storytelling and the use of temporality in leader enactment. Although narrative leadership is broadly described in previous theory as leading with storytelling, a formal theory of narrative leadership has not yet been developed. Recently, researchers have identified the narrator’s ability to locate a story within a meaningful time continuum of past, present, and future as potentially important. Using a grounded theory approach, the question that guided the research was: How does the use of time in narrative impact the enactment of leadership during a strategic change?

With the goal of developing a theory that emerges from …


Examining The Impact Of Fantasy And Cosplay On Work-Life Balance, Savannah Jo Stevens Mar 2018

Examining The Impact Of Fantasy And Cosplay On Work-Life Balance, Savannah Jo Stevens

Theses and Dissertations

The popularity concerning science-fiction and fantasy has risen exponentially. This increase in acceptance means that the impact of engaging in fantasy and cosplay has on an individual’s worklife balance requires examination. Relationships among fantasy engagement, para-social interactions, work-life balance, and identity were analyzed. Responses from 124 participants revealed a primary pattern concerning these constructs. Findings indicated some strains were experienced by occupying work and fantasy-related roles, but the gains achieved were far more significant. Findings also revealed this pattern when the connection between parasocial interactions and work-life balance was examined. Additionally, the relationship between fantasy engagement and para-social interactions, as …


Vortioxetine Improves Context Discrimination In Mice Through A Neurogenesis Independent Mechanism, Daniela Felice, Jean Philippe Guilloux, Alan Pehrson, Yan Li, Indira Mendez-David, Alain M. Gardier, Connie Sanchez, Denis J. David Mar 2018

Vortioxetine Improves Context Discrimination In Mice Through A Neurogenesis Independent Mechanism, Daniela Felice, Jean Philippe Guilloux, Alan Pehrson, Yan Li, Indira Mendez-David, Alain M. Gardier, Connie Sanchez, Denis J. David

Department of Psychology Faculty Scholarship and Creative Works

Major Depressive Disorders (MDD) patients may exhibit cognitive deficits and it is currently unclear to which degree treatment with antidepressants may affect cognitive function. Preclinical and clinical observations showed that vortioxetine (VORT, an antidepressant with multimodal activity), presents beneficial effects on aspects of cognitive function. In addition, VORT treatment increases adult hippocampal neurogenesis (AHN) in rodents, a candidate mechanism for antidepressant activity. Pattern separation (PS) is the ability to discriminate between two similar contexts/events generating two distinct and non-overlapping representations. Impaired PS may lead to overgeneralization and anxiety disorders. If PS impairments were described in depressed patients, the consequences of …


Effects Of Neonatal Handling On Play And Anxiety In F344 And Lewis Rats, Stephen M. Siviy Mar 2018

Effects Of Neonatal Handling On Play And Anxiety In F344 And Lewis Rats, Stephen M. Siviy

Psychology Faculty Publications

Play is an important part of normal childhood development and seen in many mammals, including rats. To better understand the interplay between genotype and postnatal experiences, the effects of neonatal handling on play were assessed in Lewis (LEW) and Fischer 344 (F344) rats. Handled litters experienced brief periods of separation during the first two postnatal weeks. F344 rats were less likely to direct nape contacts toward an untreated Sprague–Dawley (SD) partner and less likely to rotate to a supine position in response to a nape contact. When compared to rats from control litters, handled LEW, and F344 rats were more …


Systemic Perspective Of Conduct Disorder In Adolescents, Charmayne Adams Mar 2018

Systemic Perspective Of Conduct Disorder In Adolescents, Charmayne Adams

National Youth Advocacy & Resilience Conference

This presentation explores the systemic nature of conduct disorder and the effect it has on individuals, educational settings, and communities. It address the systemic nature of the diagnosis through Bronfenbrenner's Ecological Model and looks at interventions for each layer of the model. This presentation also acknowledges the disproportionate rate of youth-at-risk, especially male youth of color diagnosed with conduct disorder.


Vortioxetine Treatment Reverses Subchronic Pcp Treatment-Induced Cognitive Impairments: A Potential Role For Serotonin Receptor-Mediated Regulation Of Gaba Neurotransmission, Alan Pehrson, Christian S. Pedersen, Kirstine Sloth Tølbøl, Connie Sanchez Mar 2018

Vortioxetine Treatment Reverses Subchronic Pcp Treatment-Induced Cognitive Impairments: A Potential Role For Serotonin Receptor-Mediated Regulation Of Gaba Neurotransmission, Alan Pehrson, Christian S. Pedersen, Kirstine Sloth Tølbøl, Connie Sanchez

Department of Psychology Faculty Scholarship and Creative Works

Major depressive disorder (MDD) is associated with cognitive impairments that may contribute to poor functional outcomes. Clinical data suggests that the multimodal antidepressant vortioxetine attenuates some cognitive impairments in MDD patients, but the mechanistic basis for these improvements is unclear. One theory suggests that vortioxetine improves cognition by suppressing γ-amino butyric acid (GABA)ergic neurotransmission, thereby increasing glutamatergic activation. Vortioxetine's effects on cognition, GABA and glutamate neurotransmission have been supported in separate experiments, but no empirical work has directly connected vortioxetine's cognitive effects to those on GABA and glutamate neurotransmission. In this paper, we attempt to bridge this gap by evaluating …