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The Effects Of Two Novel Anti-Inflammatory Compounds On Prepulse Inhibition And Neural Microglia Cell Activation In A Rodent Model Of Schizophrenia, Heath W. Shelton

Electronic Theses and Dissertations

Recent studies have shown elevated neuroinflammation in a large subset of individuals diagnosed with schizophrenia. A pro-inflammatory cytokine, tumor necrosis factor-alpha (TNFα), has been directly linked to this neuroinflammation. This study examined the effects of two TNFα modulators (PD2024 and PD340) produced by our collaborators at P2D Bioscience, Inc., to alleviate auditory sensorimotor gating deficits and reduce microglial cell activation present in the polyinosinic:polycytidylic (Poly I:C) rodent model of schizophrenia. Auditory sensorimotor gating was assessed using prepulse inhibition and microglial activation was examined and quantified using immunohistochemistry and confocal microscopy, respectively. Both PD2024 and PD340 alleviated auditory sensorimotor gating deficits …

Conducting Publishable Research From Special Populations: Studying Children And Non-Human Primates With Undergraduate Research Assistants, Jane B. Childers, Kimberley A. Phillips

Psychology Faculty Research

Collecting publishable data with only undergraduate research assistants (RAs) is difficult; conducting research with young children or non-human primates (NHPs) adds a layer of difficulty, yet we have been able to successfully sustain and grow research programs in Developmental Psychology and primate Behavioral Neuroscience at Trinity University (TU), a primarily undergraduate institution (PUI) in San Antonio. We each have been conducting research for over 25 years, with most of that time at this type of institution, and have developed effective strategies for publishing articles with undergraduates in this environment.

Breaking Down Gesture And Action In Mental Rotation: Understanding The Components Of Movement That Promote Learning, Elizabeth M. Wakefield-Connell, Alana E. Foley, Raedy Ping, Julia N. Villarreal, Susan Goldin-Meadow, Susan C. Levine

Psychology: Faculty Publications and Other Works

Past research has shown that children’s mental rotation skills are malleable and can be improved through action experience—physically rotating objects—or gesture experience—showing how objects could rotate (e.g., Frick, Ferrara, & Newcombe, 2013; Goldin-Meadow et al., 2012; Levine, Goldin-Meadow, Carlson, & Hemani-Lopez, 2018). These two types of movements both involve rotation, but differ on a number of components. Here, we break down action and gesture into components—feeling an object during rotation, using a grasping handshape during rotation, tracing the trajectory of rotation, and seeing the outcome of rotation—and ask, in two studies, how training children on a mental rotation task through …

Elucidating The Lasting Influence Of Early Pubertal Timing On Disordered Eating Symptoms, Megan Marie Shope

UNLV Theses, Dissertations, Professional Papers, and Capstones

Objective: Extant data indicate that girls who mature earlier than their peers are at increased risk for disordered eating symptoms. Nonetheless, whether early pubertal timing exerts differential effects across key disordered eating symptoms (e.g., body weight/shape concerns vs. binge eating) and whether pubertal timing effects are present after the completion of puberty (i.e., in adulthood) remains relatively unclear. Additionally, leading theories posit that pubertal increases in adiposity and psychosocial factors (e.g., perceived pressures for thinness) likely underlie the predictive effects of earlier maturation on disordered eating risk, yet few studies have empirically tested this possibility. The current study aimed to …

Associations Of First Trimester Co-Use Of Tobacco And Cannabis With Prenatal Immune Response And Psychosocial Well-Being, Kristin Ashford, Amanda Fallin-Bennett, Andrea Mccubbin, Amanda T. Wiggins, Sheila Barnhart, Joshua A. Lile

Perinatal Research and Wellness Center Faculty Publications

PURPOSE: This study aims to describe the association of first trimester co-use of tobacco and cannabis with maternal immune response and psychosocial well-being, relative to tobacco use only.

METHODS: A preliminary midpoint analysis included 138 pregnant women with biologically verified tobacco use, 38 of whom (28%) also tested positive for recent cannabis use. Maternal perceived stress (Perceived Stress Scale), depressive symptoms (Edinburgh Postnatal Depression Scale), and serum immune markers (IL-1β, IL-2, IL-6, IL-8, IL-10, TNFα, CRP, MMP8), were collected, although cytokine data were only available for 122 women.

RESULTS: Participant average age was 29.1 years, approximately half had a high …

Constructed Response Formats And Their Effects On Minority-Majority Differences And Validity, Filip Lievens, Paul R. Sackett, Jeffrey Dahlke, Janneke Oostrom, Britt De Soete

Research Collection Lee Kong Chian School Of Business

The inflow of immigrants challenges organizations to consider alternative selection procedures that reduce potential minority (immigrants)-majority (natives) differences, while maintaining valid predictions of performance. To deal with this challenge, this paper proposes response format as a practically and theoretically relevant factor for situational judgment tests (SJTs). We examine a range of response format categories (from traditional multiple-choice formats to more innovative constructed response formats) and conceptually link these response formats to mechanisms underlying minority-majority differences. Two field experiments are conducted with SJTs. Study 1 (274 job seekers) contrasts minority-majority differences in scores on a multiple-choice versus a written constructed response …

Emotion Processing In The Survival Paradigm, Destiny Valentine

Psychology

The literature shows that words processed according to their survival relevance typically produce a memory advantage. Similarly, words containing an emotional connotation tend to lead to better memory. The current study examined whether combining both the survival processing effect and the emotion processing advantage would cause an interaction that amplified the effects on memory. Using a modified version of the traditional survival processing paradigm, participants rated emotion words (positive, negative, or neutral) on their relevance to a survival context or home-moving control context. They were later given a surprise recall task for the rated words. The results did not show …

A Study Of Beluga (Delphinapterus Leucas) Vocal Ontogeny, Audra Elizabeth Ames

Dissertations

There is a shortage of literature regarding beluga (Delphinapterus leucas) vocal ontogeny, as presently, there has only been one published study on the vocal development of beluga calves, despite the value of ontogenetic studies for our understanding of sound-centered species. Here I offer the second longitudinal study of beluga vocal development. Using a calibrated digital hydrophone with a sampling rate of 256 kHz, I studied the vocal progression of a male beluga calf in early life. From his first day, the calf produced broadband pulse trains with upper frequency limits extending past the study’s Nyquist frequency (128 kHz); …

Examining Emotional Pain Among Individuals With Chronic Physical Pain: Nomothetic And Idiographic Approaches, Madelyn Frumkin

Arts & Sciences Graduate Student Theses and Dissertations

Pain is often conceptualized as an experience that is both physical and emotional. These two components are often difficult to distinguish, which may contribute to the experience of chronic physical pain without an apparent physical cause. In the current two studies, I sought to examine whether emotional pain is associated with physical pain severity for individuals with chronic pain. Emotional pain and the more specific experiences of psychological and social pain have been defined as the experience of pain affect in response to non-physical stimuli (i.e., thwarted belongingness, loss, social rejection). In Study 1, I found that emotional and psychological …

Queerness, Witchcraft, And Embodied Presence: Aesthetic Knowings Of What A Body Can Do, Megan Bigelow

Dissertations, Theses, and Capstone Projects

Taking as a point of entry the critique of representation and affirming the limitations of the cuts that language makes, this capstone project explores the imbrications and assemblages between Foucault’s concept of subjugated knowledges, witchcraft and other body-based ways of knowing and being, and the consciousness of non-human forms such as plants and through the framework of non-representational theory, process philosophies, aesthetics, queerness, and the concept of difference itself.

Since such theories themselves are living, breathing entities, this capstone project explores the ideological split that has occurred between sacred and secular beliefs, moving through different figures such as nuns and …

Stabilizing Forces In Acoustic Cultural Evolution: Comparing Humans And Birds, Daniel C. Mann

Dissertations, Theses, and Capstone Projects

Learned acoustic communication systems, like birdsong and spoken human language, can be described from two seemingly contradictory perspectives. On one hand, learned acoustic communication systems can be remarkably consistent. Substantive and descriptive generalizations can be made which hold for a majority of populations within a species. On the other hand, learned acoustic communication systems are often highly variable. The degree of variation is often so great that few, if any, substantive generalizations hold for all populations in a species.

Within my dissertation, I explore the interplay of variation and uniformity in three vocal learning species: budgerigars (Melopsittacus undulatus), …

Social Skills Training And Generalization Of Skills In Children With Autism Spectrum Disorder, Brittany Wright

Honors Theses

The social deficits observed in individiuals with autism spectrum disorder (ASD) can often be improved with social skills training. The current study evaluated the effects of the Superheroes Social Skills training program which uses animated superheroes, video modeling, and comic books to teach social skills training. Three participants with ASD were trained in Conversation, Responding to Questions, and Body Basics over ten sessions, with sessions occurring twice a week in a non-school setting at the Arc of Southeast Mississippi. A multiple baseline across skills design across participants was used to examine the effects of the intervention on skill …

Contagious Or Not Contagious: Is That The Question? Evaluating The Effects Of Disease Contagion On Memory For Word Lists, Laura Pazos

Honors Theses

Researchers have suggested that individuals possess a disease-avoidance system designed to detect and remember potential sources of harmful pathogens, a system termed the behavioral immune system. Recently, Fernandes, Pandeirada, Soares, and Nairne (2017) reported an increase in memory for objects associated with individuals that are contaminated with a disease. My thesis extends this finding by examining whether disease-related memory benefits are due to the mere presence of a disease or whether the disease needs to be perceived as contagious and thereby threatening to facilitate memory. Two experiments, one between- and one within-subjects, were designed to test memory performance in the …

Differential Mating Motives' Influence On Preferences For Facially Communicated Extraversion, Mitch Brown

Dissertations

Human facial structures communicate personality from which one can infer another’s behavioral intentions, forming a basis for mate selection. One particularly detectable trait through facial structures is extraversion. Extraversion is a trait associated with heightened interest in promiscuous mating strategies and preferred among individuals similarly interested in short-term mating, implicating extraverted mates as ideal trait for short-term mating. Nonetheless, behavioral repertoires associated with extraversion may also pose risks, particularly in long-term mating, as their increased promiscuity may undermine their fidelity to a specific partner, thereby potentially reducing biparental investment in any offspring produced. Thus, a preference for introversion (i.e., low …

Bottlenose Dolphin (Tursiops Truncatus) Vocal Responses To Sonar And Spectrally Pink Background Noise, Maria Zapetis

Dissertations

As human populations rise, the level of man-made noise increases globally. Naval sonar and boat traffic are underwater sound sources of particular concern to marine mammal welfare. To better understand the impact of these noise increases on cetaceans, studies can explore animals’ behavioral changes in response to noise. Studies have investigated the ‘dose-response’ relationship between the received sound pressure level of sonar signals and the behavior of cetaceans in the wild, but exposure studies in controlled environments are limited. The studies in this dissertation examined bottlenose dolphin vocal modifications during various experimental noise treatments. Acoustic recordings previously obtained for bottlenose …

The Development Of Socio-Sexual Behavior In Beluga Whales (Delphinapterus Leucas), Malin K. Lilley

Dissertations

The reproductive success of the beluga whale is critical for a species facing extinction in its endangered Cook Inlet, Alaska population. To date, little is known about the mating behavior of these whales in wild populations. On the other hand, observations of beluga whales in human care allow researchers to better understand many aspects of their daily lives and life histories that are difficult to assess in wild populations. Thus far, a catalog of socio-sexual behavior has been established based on observations of belugas; however, the developmental trajectory of socio-sexual behavior is not well-understood. The present study explored how socio-sexual …

Exploring Prenatal Risk Factors Among Hispanic Children With Autism Spectrum Disorders. – A Pilot Study In The Rio Grande Valley, Lauren Tien

Dissertations and Theses (Open Access)

Background: Peer-reviewed studies suggest that a hostile gestational environment is associated with delayed neurological development in infants. Autism spectrum disorder (ASD) is estimated to affect 1 in 59 children in the United States; however, few studies have specifically investigated risk factors for autism in Hispanic children. Purpose: The University of Texas RGV Hispanic Autism Research Center (HARC) studied Hispanic children with ASD and their biological mothers to identify potential environmental exposures and prenatal risk factors that could impact the risk for ASD through preliminary research in the Rio Grande Valley. Methods: This pilot study recruited 25 Hispanic mothers and their …

The Poetic Function Of Imagination: The Parallel Process Of Poiêsis, Angela Carlson

Expressive Therapies Capstone Theses

In the advent of Postmodernism, modern approaches to understanding the nature of things is being put into question. As the gap between objective and subjective realms of experiences is narrowing, there is an increased need for a more artful approach to science. This paper serves as my attempt to promote the field of Expressive Arts Therapy (ExATh) as a mode of poetic science for understanding the experience of ‘Being’ in the world. Through a critical review of the semantic development of the ancient Greek concepts poiêsis, noêsis, and aisthêsis, the imagination is identified as a function of alêthaic revealing, …

Tests Of An Indifference Rule In Variable-Delay And Double-Reward Choice Procedures With Humans, Todd Mckerchar, James E. Mazur

Research, Publications & Creative Work

Four-hundred and fifty participants were recruited from Amazon Mechanical Turk across three experiments to test the predictions of a hyperbolic discounting equation in accounting for human choices involving variable delays or multiple rewards (Mazur, 1984, 1986). In Experiment 1, participants made hypothetical choices between two monetary alternatives, one consisting of a fixed delay and another consisting of two delays of equal probability (i.e., a variable-delay procedure). In Experiment 2, participants made hypothetical monetary choices between a single, immediate reward and two rewards, one immediate and one delayed (i.e., a double-reward procedure). Experiment 3 also used a double-reward procedure, but with …

Illusory Boundaries And Perceived Access To Rural Mental Health Care, Caitlin M. Shelby

Honors College Theses

This study examined the potential effects of illusory boundaries (in the form of county lines on a map) on distance judgments, specifically distance to mental health care (therapy) and perceived accessibility to said mental health care. 47 undergraduate psychology students completed our study through SONA on Qualtrics. Participants were presented with a series of 10 maps. Each map had two pins, one labelled “you are here” and the other labelled “therapy location” with a key on the bottom for reference (however, participants were instructed to not use their fingers as a measurement tool to keep the distance judgment a perceived …

A Consensus Guide To Capturing The Ability To Inhibit Actions And Impulsive Behaviors In The Stop-Signal Task., Frederick Verbruggen, Adam R Aron, Guido Ph Band, Christian Beste, Patrick G Bissett, Adam T Brockett, Joshua W Brown, Samuel R Chamberlain, Christopher D Chambers, Hans Colonius, Lorenza S Colzato, Brian D Corneil, James P Coxon, Annie Dupuis, Dawn M Eagle, Hugh Garavan, Ian Greenhouse, Andrew Heathcote, René J Huster, Sara Jahfari, J Leon Kenemans, Inge Leunissen, Chiang-Shan R Li, Gordon D Logan, Dora Matzke, Sharon Morein-Zamir, Aditya Murthy, Martin Paré, Russell A Poldrack, K Richard Ridderinkhof, Trevor W Robbins, Matthew Roesch, Katya Rubia, Russell J Schachar, Jeffrey D Schall, Ann-Kathrin Stock, Nicole C Swann, Katharine N Thakkar, Maurits W Van Der Molen, Luc Vermeylen, Matthijs Vink, Jan R Wessel, Robert Whelan, Bram B Zandbelt, C Nico Boehler

Brain and Mind Institute Researchers' Publications

Response inhibition is essential for navigating everyday life. Its derailment is considered integral to numerous neurological and psychiatric disorders, and more generally, to a wide range of behavioral and health problems. Response-inhibition efficiency furthermore correlates with treatment outcome in some of these conditions. The stop-signal task is an essential tool to determine how quickly response inhibition is implemented. Despite its apparent simplicity, there are many features (ranging from task design to data analysis) that vary across studies in ways that can easily compromise the validity of the obtained results. Our goal is to facilitate a more accurate use of the …

Effects Of Chemogenetic Inhibition Of Ventral Hippocampal Glutamatergic Neurons On Anxiety-Like Defensivity In Male Long-Evans Hooded Rats, Carlos R. Maestas-Olguin

Psychology ETDs

Previous research in rodents and humans has implicated the ventral hippocampus in regulating anxiety. However, many rodent studies examining ventral hippocampal neuronal pathways have utilized lesions that create nonspecific and/or nonreversible damage to the region. The present study sought to characterize the role of ventral hippocampal glutamatergic pyramidal neurons in modulating anxiety-like behavior during exposure to a variety of threatening stimuli. Five weeks prior to testing, male Long-Evans hooded rats received ventral hippocampal viral-vector infusions expressing either pAAV-CaMKIIα-hM4D-mCherry (DREADD) or pAAV-CaMKIIa-EGFP (GFP). DREADD transfection allowed for the specific, noninvasive and temporary inhibition of ventral hippocampal glutamatergic neurons immediately before threat …

Exploring The Influence Of Relational Frame Theory On The Treatment Acceptability Of Noncontingent Reinforcement, Amanda R. Rohan

Theses and Dissertations

Noncontingent reinforcement (NCR), delivered on a fixed-time schedule, is a behavioral and evidence-based intervention recommended by school psychologists that may be underutilized due to resistance to behaviorally-orientated strategies, which often conflict with the child-centered training philosophies of teachers (Bear, 2013). Due to training rooted different learning philosophies, the language and verbal repertoires amongst these professionals may not always be consistent, presenting a barrier to effective communication. Relational Frame Theory (RFT) holds that the core of human language and cognition is the ability to learn to relate terms and ideas and has been effectively used to alleviate communication barriers by expanding …

The Association Of Body Mass Index With Cardiac Recovery From Psychological Stress Among Trauma-Exposed Women, Jeffrey L. Kibler, Mindy Ma

Faculty Proceedings, Presentations, Speeches and Lectures

No abstract provided.

This Or That?: Object Individuation In Domesticated Dogs (Canis Lupus Familiaris), Ellen Stumph

Honors Projects

Functioning in our everyday lives requires that humans rely on organizing and categorizing our world. This ability to categorize rests on object individuation, the ability to track the identity of objects when they leave and reenter sight. Objects can be individuated using three types of information: spatiotemporal, object property and object kind. Surprisingly, noun comprehension may affect infants’ use of object kind information (Xu 1999; Xu 2002). However, research using a comparative approach suggests that the ability to use kind information to aid in object individuation may not be unique to humans: great apes, rhesus monkeys and dogs all successfully …

Increasing Variable Play In Children With Autism Using A Lag Schedule And Stimulus Fading, Amelia Nelson

Thesis Projects

Restricted or repetitive interests are one of the hallmark characteristics of an autism diagnosis, and this characteristic can sometimes be present in a child’s toy-play. The current study explored the effects of a lag schedule and visual discriminative stimuli on the variability of selection of play items for two children with autism. The researcher used an ABAB reversal design to reinforce variability in play selection and then slowly and systematically faded the stimuli associated with the intervention. The results were idiosyncratic across participants. For one subject, the lag schedule alone maintained variable selection of toys, and the visual discriminative stimuli …

Synchronicity: The Role Of Midbrain Dopamine In Whole-Brain Coordination, Jeff A. Beeler, Jakob Kiskye Dreyer

Publications and Research

Midbrain dopamine seems to play an outsized role in motivated behavior and learning. Widely associated with mediating reward-related behavior, decision making, and learning, dopamine continues to generate controversies in the field. While many studies and theories focus on what dopamine cells encode, the question of how the midbrain derives the information it encodes is poorly understood and comparatively less addressed. Recent anatomical studies suggest greater diversity and complexity of afferent inputs than previously appreciated, requiring rethinking of prior models. Here, we elaborate a hypothesis that construes midbrain dopamine as implementing a Bayesian selector in which individual dopamine cells sample afferent …

Recovery After Genocide: Understanding The Dimensions Of Recovery Capital Among Incarcerated Genocide Perpetrators In Rwanda, Kevin Barnes-Ceeney, Lior Gideon, Laurie Leitch, Kento Yasuhara

Criminal Justice Faculty Publications

Utilizing survey data from 302 men and women incarcerated in the Rwandan correctional system for the crime of genocide, and structured interviews with 75 prisoners, this mixed methods study draws on the concept of recovery capital to understand how individuals convicted of genocide navigate post-genocide healing. Genocide smashes physical and human capital and perverts social and cultural capital. Experiencing high levels of posttraumatic stress symptoms with more than two-thirds of the sample scoring above typical civilian cut-off levels, raised levels of depression, and high levels of anxiety, and failing physical health, the genocide perpetrators require multiple sources of recovery capital …

Managing Madness: The Ethics Of Identifying And Treating Mental Illness, Mason Seely

Helene Lafrance Library Undergraduate Research Award

This essay analyzes different contemporary models for defining mental illness and offers a new framework that promotes the use of normative values during the clinical diagnostic process. Although ethic centric models for identifying mental illness do currently exist, these accounts are limited. Specifically, these accounts acknowledge the relationship between mental illness labels and implied responsibility in making their argument to support a normative framework, yet do not explain what capacities are necessary for an agent to have full responsibility. Recognizing this shortcoming, this paper provides an enriched model for identifying mental illness by marrying a normative conception of psychiatric dysfunction …

Mixed Mood State Behaviors And Circadian Dysfunction Following Homocysteic Acid Treatment: Potential Animal Model For Bipolar Disorder, Lauren Evert, Gonzalo Moya, Ryann Felton, Garrett Fogo, Nicholas Rozema, Sarah Plowman, Tymi Staub

18th Annual Celebration of Undergraduate Research and Creative Activity (2019)

Bipolar disorder is a neuropsychiatric disease characterized by cyclical fluctuations of mood states between mania and depression. Circadian rhythm abnormalities and inconsistent sleep patterns are two common symptoms of bipolar disorder (Millar, Epsie, & Scott, 2004). Elevated levels of homocysteine, in the blood or cerebrospinal fluid, commonly occurs in patients with neuropsychiatric illnesses, including bipolar disorder (Bell et al., 1992; Boushey, Beresford, Omenn, & Motulsky, 1995). Homocysteic acid (HCA), an endogenous metabolite of homocysteine, has been implicated as a harmful neurotoxin and agonist of NMDA receptors. We have previously shown that postnatal administration of HCA (from postnatal day 3-21) in …