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Articles 2191 - 2220 of 12641
Full-Text Articles in Entire DC Network
Effects Of Brief-Signal Number And Location On Responding Maintained By Delay Of Reinforcement, Firdavs Khaydarov
Effects Of Brief-Signal Number And Location On Responding Maintained By Delay Of Reinforcement, Firdavs Khaydarov
Graduate Theses, Dissertations, and Problem Reports (ETD)
The purpose of the present series of experiments was to examine the effects of the number, type, and location of brief signal(s) occurring during, but not throughout, a delay period, on responding maintained by the delay of reinforcement. In each experiment, a tandem variable time (VT) 60-s fixed interval (FI) 9-s schedule was used as a baseline condition of an immediate reinforcement against which delay conditions were examined. For the delay conditions, a chained variable interval (VI) 60-s fixed time (FT) 9-s (delay period) schedule was used, and the imposition of the brief signal (blackout) during the delay period was …
Effects Of Aripiprazole Alone And In Combination With D-Amphetamine On Probability Discounting In Sprague-Dawley Rats, Paige Currie
Effects Of Aripiprazole Alone And In Combination With D-Amphetamine On Probability Discounting In Sprague-Dawley Rats, Paige Currie
Graduate Theses, Dissertations, and Problem Reports (ETD)
Pharmaceuticals are helpful tools in aiding individuals with psychiatric diagnoses. Sometimes, the drug’s side effects can be more severe than the initial problem. Maladaptive behaviors, like pathological gambling, overeating, and substance abuse, are important to consider during the prescription of different pharmaceuticals, particularly those used to treat Attention-Deficit/Hyperactivity Disorder (ADHD) and autism spectrum disorder (ASD). Individuals with these diagnoses are often prescribed: stimulants, like d-amphetamine (d-AMP; for symptoms associated with ADHD), and antipsychotics, like aripiprazole (ARI; for symptoms associated with ASD). These drugs in combination could influence maladaptive behavior, including risky choice (probability discounting). The present study …
Effects Of Development On Hpa Function Following Pubertal Stress, Brittany D. Elliott
Effects Of Development On Hpa Function Following Pubertal Stress, Brittany D. Elliott
Graduate Theses, Dissertations, and Problem Reports (ETD)
For women, two of the greatest risk factors for affective disorders are adversity experienced during puberty and later becoming pregnant. We have created a translationally relevant mouse model where we address these complex risk factors. Previously, we discovered that pregnant mice (dams) that experienced chronic variable stress (CVS) during puberty display a blunted hypothalamic-pituitary-adrenal (HPA) response when exposed to an acute stressor. Interestingly, this alteration only first becomes apparent during pregnancy, which is a sensitive period for these effects due to normative neuroendocrine changes. Further investigation of the mechanisms underlying this dysfunction revealed altered gene expression in the paraventricular nucleus …
Evaluation Of Renewal During Differential Reinforcement With Asymmetrical Choices And A Context Fading Mitigation Technique, Kacey R. Finch
Evaluation Of Renewal During Differential Reinforcement With Asymmetrical Choices And A Context Fading Mitigation Technique, Kacey R. Finch
Graduate Theses, Dissertations, and Problem Reports (ETD)
Successful clinical behavior analytic treatment often results in decreases in challenging behavior and increases in appropriate behavior. These reductions in challenging behavior are often achieved by implementing differential reinforcement of alternative behavior (DRA; Petscher et al., 2009). One variation of DRA to decrease challenging behavior is differential reinforcement with asymmetrical choices, which are two or more concurrently available response options associated with differential outcomes (Fisher & Mazur, 1997; Kestner et al., 2023). However, responding that was previously reduced sometimes reemerges. Specifically, renewal is the reemergence of a previously reduced response following a context change. The first two experiments evaluated renewal …
Effects Of Oxycodone And Methylphenidate On Self-Control With Aversive Outcomes, Jeremy Saul Langford
Effects Of Oxycodone And Methylphenidate On Self-Control With Aversive Outcomes, Jeremy Saul Langford
Graduate Theses, Dissertations, and Problem Reports (ETD)
In the context of choice, one is said to show self-control under numerous conditions in which consideration is given to the delayed outcomes of each option. This can be difficult: both reinforcing and aversive outcomes become less effective as they are increasingly delayed. Several socially significant issues arise from a failure of delayed, aversive outcomes to impact choice, especially when immediate, reinforcing outcomes are available. Identifying the conditions under which choice is sensitive to delayed outcomes is critical to shifting choices toward alternatives in which contact with delayed, aversive outcomes is minimized. Two experiments were conducted with the aim of …
Response Maintenance By Mediated Reinforcement With Forced Alternation Of Reinforcement Opportunities, Kento Yasukawa
Response Maintenance By Mediated Reinforcement With Forced Alternation Of Reinforcement Opportunities, Kento Yasukawa
Graduate Theses, Dissertations, and Problem Reports (ETD)
Three experiments were conducted to investigate the effects of mediated reinforcement –reinforcers delivered to either of two co-actors by the responses of the other co-actor, but independently of the responses of the co-actor receiving the reinforcer– on the maintenance of responding of the co-actors. In each experiment, using a discrete-trials procedure, responding and receiving reinforcers alternated between co-actors. In Experiment 1, the alternation followed each reinforcer. Also investigated in this experiment were the effects of the presence and absence of social stimuli and of the role of reinforcement delays on individual responding. The number of consecutive reinforcer deliveries to either …
Effects Of Combined Ethanol And Nicotine Administration On Delay Discounting In Male And Female Sprague-Dawley Rats, Rebecca Lillian Chalme
Effects Of Combined Ethanol And Nicotine Administration On Delay Discounting In Male And Female Sprague-Dawley Rats, Rebecca Lillian Chalme
Graduate Theses, Dissertations, and Problem Reports (ETD)
Ethanol (EtOH) and nicotine (NIC) are among the most commonly used and co-used drugs in the world. Co-use occurs in people who use one or both drugs chronically, but also in people who only consume one or both drugs acutely, often in a “bingeing and chipping” pattern. Given that each drug on its own has previously been shown to affect impulsive choice in delay-discounting procedures, with some indication that drug effects could vary by sex, the purpose of the present experiments was to investigate effects of combined EtOH and NIC at a range of dose combinations on delay discounting in …
Effects Of Ethanol And Nicotine Co-Administration On Risky Choice In Rats, Erin E. Wylie
Effects Of Ethanol And Nicotine Co-Administration On Risky Choice In Rats, Erin E. Wylie
Graduate Theses, Dissertations, and Problem Reports (ETD)
Individuals often engage in the comorbid use of alcohol (ethanol) and nicotine, leading to further-escalated health consequences than the use of either drug in isolation. Given the poor health outcomes resulting from the combined administration of ethanol and nicotine, some of which may be due to increased risky choice, more basic research is needed to better characterize drug/dose interactions on risky choice. Probability-discounting procedures involve a series of discrete choices between a smaller, certain reinforcer (i.e., a safer choice) and a larger, increasingly uncertain reinforcer (i.e., a riskier choice). Probability-discounting procedures allow for the assessment of …
Cue Reactivity In Electronic Cigarette Users With Sign-Tracking Or Goal-Tracking Behaviors, Polina Krom
Cue Reactivity In Electronic Cigarette Users With Sign-Tracking Or Goal-Tracking Behaviors, Polina Krom
Graduate Theses, Dissertations, and Problem Reports (ETD)
Polina Krom
Cue reactivity is an important predictor of addiction course and relapse. However, cue reactivity is only observed after an addiction develops. As such, it is unclear to what degree cue reactivity represents a state stemming from the addiction process versus a trait-like propensity towards developing cue-reward associations. Work in animal models has pointed to important individual differences in trait-like inclination to attribute incentive salience to reward-predictive cues that is associated with addiction-relevant behavioral and neurobiological features. These individual differences manifest as sign-tracking (ST) and goal-tracking (GT) behaviors during Pavlovian conditioning. Little research has attempted to translate ST and …
What Gives? Leveraging Marketing Knowledge To Increase Consumers’ Charitable Giving, Caitlin Michael
What Gives? Leveraging Marketing Knowledge To Increase Consumers’ Charitable Giving, Caitlin Michael
Graduate Theses, Dissertations, and Problem Reports (ETD)
Marketing plays a central role in nonprofit organizations that compete for the donations of individual consumers to achieve their respective missions. To this end, marketing researchers and practitioners have devoted much attention to the antecedents of charitable giving and ways in which solicitations may be made more effective and efficient. This gives rise to the questions: “What has the field learned?” and, relatedly, “What novel effects have not yet been explored?” Within this dissertation, three essays address these questions through the use of multiple methodologies.
The first essay seeks to outline what the marketing field has learned about consumers’ charitable …
The Metanarratives Of The Fourth Industrial Revolution And The Collective Cognitive Dissonance Of Metamodernist Discursive Formation, John R. Lewis
The Metanarratives Of The Fourth Industrial Revolution And The Collective Cognitive Dissonance Of Metamodernist Discursive Formation, John R. Lewis
College of Graduate Studies: Theses & Dissertations
My artworks explore the impacts of the technology of the Fourth Industrial Revolution, which began in the early 21st Century, upon global society and the human psyche. My works are instantiated by multi-year research in the areas of social psychology, cognitive dissonance, computer evolution and artificial intelligence. My body of work portrays a cautionary sensibility regards new technologies such as robotics, quantum supercomputing, Artificial Intelligence, commercial space travel and nanotechnology. In addition, my artwork attempts to increase awareness of the phenomenon of cognitive dissonance.
The perceptions and cognitions of artistic viewers relate directly to the psychological phenomenon of cognitive …
Decision Making Related To Situations When Sexual Violence Might Occur, Shakeia Salem
Decision Making Related To Situations When Sexual Violence Might Occur, Shakeia Salem
College of Graduate Studies: Theses & Dissertations
The definition of sexual violence has changed over the years to include all unconsented sexual contact. Sexual violence is a global issue targeting young, college-aged adults. We used hypothetical scenarios to determine the discounting rates of participants in situations where sexual violence might occur. Undergraduate students (n = 146; mean age 20.18 years) from Georgia Southern University participated in our study. The sample of participants included 116 (79.45%) females and 30 (20.55%) males, identifying as White (n = 85; 58.22%), Hispanic (n = 5; 3.42%), Black (n = 28; 19.18%), Asian (n = 1; .68%), …
Covid-19 Stress And Cognitive Failures In Daily Life: A Multilevel Examination Of Within- And Between-Persons Patterns, Nadyanna M. Majeed, K. T. A. Sandeeshwara Kasturiratna, Mingyao Li, Jonathan L. Chia, Verity Y. Q. Lua, Andree Hartanto
Covid-19 Stress And Cognitive Failures In Daily Life: A Multilevel Examination Of Within- And Between-Persons Patterns, Nadyanna M. Majeed, K. T. A. Sandeeshwara Kasturiratna, Mingyao Li, Jonathan L. Chia, Verity Y. Q. Lua, Andree Hartanto
Research Collection School of Social Sciences
The COVID-19 pandemic has claimed an extremely high number of lives worldwide, causing widespread panic and stress. The current research examined whether COVID-19 stress was associated with everyday cognitive failures, using data from a seven-day daily diary study of 253 young adults in Singapore. Multilevel modeling revealed that COVID-19 stress was significantly associated with cognitive failures even after adjusting for demographic factors, both at the within-person and between-persons levels. Specifically, individuals experienced more cognitive failures on days they experienced more COVID-19 stress (as compared to their own average levels of COVID-19 stress), and individuals who experienced more COVID-19 stress overall …
Religiosity, Family Sexual Communication & Gender As Predictors Of Attitudes Toward Oral Sex Among College/University Students In The United States, Antoinette Napier
Religiosity, Family Sexual Communication & Gender As Predictors Of Attitudes Toward Oral Sex Among College/University Students In The United States, Antoinette Napier
Dissertations
Purpose
The purpose of this study was to investigate whether religiosity, family sexual communication and gender were predictors of attitudes toward oral sex among college/university students in the United States.
Method
Participants completed several surveys, which measured participants' personal religiosity, family sexual communication, and attitudes toward oral sex. A path analysis model was used to analyze the relationship between the proposed variables.
Results
The path analysis hypothesized model resulted in a poor fit for the data. The model was respecified by removing three items which showed weak beta weights. The respecified model produced a good fit for the data. The …
A Constructivist Grounded Theory Analysis Of Seven Medical Provider Perspectives On Major Barriers To Prescribing Buprenorphine To Youth With Opiold Use Disorder In Outpatient Medical Settings: "We Should Be Providing Them With What We Know To Be The Gold Standard Of Care"., Maeve O'Leary Sloan
Antioch University Dissertations & Theses
This study utilized Primary Care Provider (PCP) perspectives to unveil major barriers to prescribing buprenorphine to youth (ages 16-25) with opioid use disorder (OUD). Semi-structured interviews were conducted with seven PCPs recruited through convenience and snowball sampling. Interviews were conducted and recorded via Zoom video conferencing. Transcripts were generated and analyzed for themes using a Constructivist Grounded Theory (CGT) approach. The CGT of the present study describes four major barriers that limit PCP prescription of buprenorphine to youth: 1) PCPs Feel Overwhelmed, 2) PCPs Feel Ill Equipped to Treat Youth Patients with OUD, 3) PCPs Hold and Observe Stigma toward …
"The Power To Heal And Cure": Adaptations Of Western Therapy By American Indian And Alaska Native Therapists, Calleaghn B. Kinnamon
"The Power To Heal And Cure": Adaptations Of Western Therapy By American Indian And Alaska Native Therapists, Calleaghn B. Kinnamon
Antioch University Dissertations & Theses
The legacy of colonialism has created a modern-day reality where Indigenous populations of the United States (US) experience mental, physical, and emotional distress at disproportionately higher rates than other cultural groups in the country. Increased distress translates to an increased need for supportive services. Because the field of Western Psychology is based in colonialistic EuroWestern worldviews which positions that worldview as superior, Indigenous clients and communities have often experienced further harm in their encounters with mental health services. In recent decades, there has been increasing attention to adapting research, training, academic and clinical work in ways that are culturally appropriate …
How Racial Trauma Manifests In Black Women From Direct And Indirect Encounters With Police Brutality, Ashley Turner
How Racial Trauma Manifests In Black Women From Direct And Indirect Encounters With Police Brutality, Ashley Turner
Antioch University Dissertations & Theses
This phenomenological study explored Black women’s lived experiences with racial trauma stemming from direct and indirect encounters with police brutality. A total of nine participants living in Washington state participated in this study. They identified as Black, ciswomen, fluent in English, and at least 21-years-old. In-depth, semi-structured, qualitative interviews were conducted to explore participants’ experiences with police. Transcripts were analyzed using interpretative phenomenological analysis. The results consisted of the following five themes: (a) forms of police encounters, (b) influence of identity, (c) perceived reason for police brutality, (d) emotions stemming from police brutality, and (e) tactics to survive police interactions. …
How Cultural Believes Support And Perpetuate Relational Violence: A Delphi Study For Violence Prevention, Alisha D. Guthery
How Cultural Believes Support And Perpetuate Relational Violence: A Delphi Study For Violence Prevention, Alisha D. Guthery
Antioch University Dissertations & Theses
This study solicited experts in relational violence across the United States using the Delphi methodology and grounded theory. This research was conducted in two phases and designed to answer two primary questions: (1) What cultural beliefs are involved in relational violence in the United States? And (2) How are the beliefs about relational violence maintained? The findings showed agreement from the experts on the societal beliefs that hold relational violence, the specific beliefs held by the abuser, and the impacts of these beliefs on the survivor. The experts offered ideas for intervention and prevention, which are important contributions to professional …
Interpersonal Emotions As Emergent Phenomena: Social Neuroscience Beyond Western Cultural Constructions, Kaitlyn Penchina
Interpersonal Emotions As Emergent Phenomena: Social Neuroscience Beyond Western Cultural Constructions, Kaitlyn Penchina
Scripps Senior Theses
Because science as it exists today is a cultural construction of the West, studies of neuroscience have often been limited by Western perspectives. In particular, the Western proclivity towards individualism has led to a field of neuroscience which has historically focused on studying single individuals, as opposed to social or collective neuroscience. For the most part, it has just been assumed that collective phenomena such as interpersonal emotions must be able to be reduced in terms of individual phenomena such as individual emotions. However, closer review reveals that interpersonal emotions have emergent properties that individual emotions alone do not account …
Alpha Band Prefrontal Asymmetry Does Not Underlie Pain Approach-Avoidance: Results From Two Eeg Studies, Tracy W. Brown, Kayli N. Colpitts, Cristian M. Botello, Abby K. Hartman, Kathryn P. Seymour
Alpha Band Prefrontal Asymmetry Does Not Underlie Pain Approach-Avoidance: Results From Two Eeg Studies, Tracy W. Brown, Kayli N. Colpitts, Cristian M. Botello, Abby K. Hartman, Kathryn P. Seymour
Psychological Science Faculty Publications
Pain research is often focused on escape from pain or approach of relief, yet individuals with chronic pain make complex choices to face their pain to satiate other drives (approach-avoidance conflicts). An abundance of research has indicated that prefrontal alpha band asymmetry (PFA) underlies approach-avoidance in general, but there is limited information about whether PFA underlies pain approach-avoidance conflicts. Electroencephalogram activity was recorded while 70 participants with chronic pain (n=33) and without chronic pain (n=37) approached/avoided stimuli containing simultaneous pain (low-high) and monetary reward (low-high). Findings from both studies revealed that approach-avoidance for pain stimuli is not accompanied by prefrontal …
Psycho-Spiritual Counselling To Enhance Resiliency As Transformative Education: An Auto/Ethnographic Inquiry Of The Interface Between Spirituality And Positive Psychology, Dominic Savio
Theses: Doctorates and Masters
This thesis attempts to capture my lived experiences of psychospiritual counselling and to describe how my research journey has shaped me personally and professionally. As a priest engaged in psychospiritual counselling internationally for nearly three decades in diverse settings, I attempt to seek further clarity and make sense of my rich experiences in this research. Therefore, I endeavoured to investigate if and how building resiliency through psychospiritual counselling can be comprehended as transformative education.
Experientially speaking, as a priest and psychospiritual counsellor, I recognised that people leaned on their moral vulnerabilities and were blinded to spirituality as a source of …
Evaluating Growth Rates Of The Eastern Oyster (Crassostrea Virginica) And Water Quality For Oyster Restoration Sites At City Island, Bronx, Ny, Cody L. Jernigan
Evaluating Growth Rates Of The Eastern Oyster (Crassostrea Virginica) And Water Quality For Oyster Restoration Sites At City Island, Bronx, Ny, Cody L. Jernigan
Theses and Dissertations
Oyster growth and water quality were monitored at four sites at City Island, Bronx, NY, to determine suitability for oyster reef restoration. Significant growth occurred at two sites and water quality was not indicated as a contributing factor. Oyster growth at all sites indicate appropriate conditions for oyster reef restoration.
Extensions Beyond Program Impacts: Conceptual And Methodological Considerations In Studying The Implementation Of A Preschool Social Emotional Learning Program, Jaiya Rae Choles, Robert W. Roeser, Andrew Mashburn
Extensions Beyond Program Impacts: Conceptual And Methodological Considerations In Studying The Implementation Of A Preschool Social Emotional Learning Program, Jaiya Rae Choles, Robert W. Roeser, Andrew Mashburn
Psychology Faculty Publications and Presentations
Social–emotional learning (SEL) programs are frequently evaluated using randomized controlled trial (RCT) methodology as a means to assess program impacts. What is often missing in RCT studies is a robust parallel investigation of the multi-level implementation of the program. The field of implementation science bridges the gap between the RCT framework and understanding program impacts through the systematic data collection of program implementation components (e.g., adherence, quality, responsiveness). Data collected for these purposes can be used to answer questions regarding program impacts that matter to policy makers and practitioners in the field (e.g., Will the program work in practice? Under …
Gender Ambiguity In Voice-Based Assistants: Gender Perception And Influences Of Context, Sandra Mooshammer, Katrin Etzrodt
Gender Ambiguity In Voice-Based Assistants: Gender Perception And Influences Of Context, Sandra Mooshammer, Katrin Etzrodt
Human-Machine Communication
Recently emerging synthetic acoustically gender-ambiguous voices could contribute to dissolving the still prevailing genderism. Yet, are we indeed perceiving these voices as “unassignable”? Or are we trying to assimilate them into existing genders? To investigate the perceived ambiguity, we conducted an explorative 3 (male, female, ambiguous voice) × 3 (male, female, ambiguous topic) experiment. We found that, although participants perceived the gender-ambiguous voice as ambiguous, they used a profoundly wide range of the scale, indicating tendencies toward a gender. We uncovered a mild dissolve of gender roles. Neither the listener’s gender nor the personal gender stereotypes impacted the perception. However, …
Predictors Of Online Faculty's Organizational Commitment, Anna Carroll Stevens
Predictors Of Online Faculty's Organizational Commitment, Anna Carroll Stevens
Doctoral Dissertations and Projects
Online higher education is a booming industry; however, concerns have been voiced about the quality of online education. As a significant participant in the online environment, the online faculty member plays an essential role in the delivery of quality online education. Yet, research on online faculty and their experience is limited. With high turnover rates and the quality of online education coming into question, this mixed methods study sought to gain a more in-depth understanding of the predictors of online faculty’s organizational commitment. The delivery method of faculty’s previous educational experience as a student, their highest earned degree, employee status, …
A Qualitative Study Into Modern Psychoanalytic Joining And Mirroring Through Psychotherapeutic Exchanges, Tricia Shihui Wang
A Qualitative Study Into Modern Psychoanalytic Joining And Mirroring Through Psychotherapeutic Exchanges, Tricia Shihui Wang
Electronic Theses and Dissertations
This dissertation intends to address current deficits in knowledge regarding the modern psychoanalytic interventions of joining and mirroring, including substantial definition issues in the literature and the absence of current writings on the psychotherapeutic interventions of joining and mirroring in practice. The focus of the study was on the ever-dynamic landscape between modern analytically-informed practitioners and their clients in psychotherapeutic exchange(s) that the practitioners believed encompassed joining and/or mirroring interventions. Participants were six experienced practitioners who described their clinical work as being informed by modern psychoanalysis and who have engaged or were currently engaging in individual psychotherapy with a client. …
Developing Queer Faith: Exploring Experiences Of Cognitive Dissonance And Identity Integration For Lgbq Catholics Individuals, Kendal M. Vaarwerk
Developing Queer Faith: Exploring Experiences Of Cognitive Dissonance And Identity Integration For Lgbq Catholics Individuals, Kendal M. Vaarwerk
Doctoral Dissertations
While religion may be meeting existential needs, it may, at the same time, be asking the LGBQ youth to be someone different than who they are (Longo et al., 2018). LGBQ individuals experience severe cognitive and emotional consequences because of oppressive religious doctrine, including guilt, shame, self-loathing, and suicidal ideation (Schuck & Liddle, 2001). When LGBQ individuals are involved with religious belief systems that cast rejecting or disapproving messages about LGBQ individuals, these individuals often experience more internalized negative self-messages, as well as more significant challenges in developing and accepting one’s sexual identity (Page et al., 2013). Therefore, this very …
The Effects Of Active Shootings On 4-H Youth And Families, Melinda Garcia, Elizabeth Gangwer
The Effects Of Active Shootings On 4-H Youth And Families, Melinda Garcia, Elizabeth Gangwer
Journal of Extension
The effects of active shootings should be a priority to provide needed assistance to 4-H youth and families in coping with their social-emotional well-being. Exposure to such violence can lead to lasting impacts on youth that can affect behavior. Addressing this sensitive topic is crucial in ensuring that Extension professionals are prepared to meet the needs of youth and families. Higher rates of depression, aggression, to name a few, are a result of having witnessed such events as a shooting. Providing training for Extension personnel can aid in reducing the amount of PTSD and other social-emotional trauma.
Evaluating Evidence Of Episodic Tendencies During Semantic Fluency, Rebecca Anne Wilder
Evaluating Evidence Of Episodic Tendencies During Semantic Fluency, Rebecca Anne Wilder
Theses - ALL
While semantic organization has been widely observed in episodic memory tasks, episodic organization has yet to be observed in the semantic fluency task, due to structural differences between test paradigms. Episodic memory effects require an opportunity for target information to first be learned and later retrieved. Semantic fluency tasks, which are designed to measure retrieval capacity for facts, are typically limited to a single test-phase format. In semantic fluency tasks, participants are presented with a semantic retrieval cues (i.e. category prompts) and asked to list as many items as they can think of that fit the classification. The repeated fluency …
Tiam1-Mediated Synaptic Plasticity Underlies Comorbid Depression-Like And Ketamine Antidepressant-Like Actions In Chronic Pain, Qin Ru, Yungang Lu, Ali Bin Saifullah, Francisco A Blanco, Changqun Yao, Juan P Cata, De-Pei Li, Kimberley F Tolias, Lingyong Li
Tiam1-Mediated Synaptic Plasticity Underlies Comorbid Depression-Like And Ketamine Antidepressant-Like Actions In Chronic Pain, Qin Ru, Yungang Lu, Ali Bin Saifullah, Francisco A Blanco, Changqun Yao, Juan P Cata, De-Pei Li, Kimberley F Tolias, Lingyong Li
Faculty, Staff and Students Publications
Chronic pain often leads to depression, increasing patient suffering and worsening prognosis. While hyperactivity of the anterior cingulate cortex (ACC) appears to be critically involved, the molecular mechanisms underlying comorbid depressive symptoms in chronic pain remain elusive. T cell lymphoma invasion and metastasis 1 (Tiam1) is a Rac1 guanine nucleotide exchange factor (GEF) that promotes dendrite, spine, and synapse development during brain development. Here, we show that Tiam1 orchestrates synaptic structural and functional plasticity in ACC neurons via actin cytoskeleton reorganization and synaptic N-methyl-d-aspartate receptor (NMDAR) stabilization. This Tiam1-coordinated synaptic plasticity underpins ACC hyperactivity and drives chronic pain-induced depressive-like behaviors. …