Digital Commons Network^™

Flash-Rt: Using High-Dose Radiation For Clinical Radiation Therapy, Deja Stubbs

University Honors Theses

This paper is a literature review on the possible mechanisms behind the FLASH effect and why such research can advance the world of radiology treatment by modifying current clinical linear accelerators to produce ultra-high doses of radiation. Radiation Therapy, also known as external Beam Radiation Therapy, is a common type of cancer treatment. Globally, cancer is the second-leading cause of death, but has seen an increase in survival rates over the past couple of years. Cancer can develop in almost any part of the body since cancer is defined as uncontrolled cell growth. The FLASH Effect is seen when treating …

Stability Of Retinol In Liposomes As Measured By Fluorescence Lifetime Spectroscopy And Flim, Louis Sumrall, L. Smith, Elmukhtar Ehmed Alhatmi, Yekaterina G. Chmykh, D. Mitchell, Jay Nadeau

Physics Faculty Publications and Presentations

Retinol shows complex photophysical properties that make it potentially useful as an exogenous or endogenous probe of membrane microenvironment, but it has not been fully explored. In this study, we use bulk fluorescence lifetime measurements and fluorescence lifetime imaging microscopy (FLIM) to examine the stability of retinol in phosphatidylcholine (PC) multilamellar and unilamellar vesicles with and without cholesterol. We find that both light and exposure to ambient temperature and oxygen contribute to retinol degradation, with the addition of an antioxidant such as butylated hydroxytoluene (BHT) essential to provide stability, especially in the absence of cholesterol. With exposure to ultraviolet light …

Non-Degenerate Two-Photon Absorption And Excited State Line Shapes In Alkali Vapors, Timothy M. True

Theses and Dissertations

The rubidium 5S-5D two-photon transitions were probed between 758-798 nm, where a six order of magnitude change in the cross section was observed and the polarization dependence was seen explicitly. Collisional rates are measured in cesium on the 6P-9S and 5D-10F transitions, with broadening rates as large as 710 MHz/Torr and shifting rates as large as 273 MHz/Torr. We observe Stark broadening on the cesium 5D-10F line shape, with Lorentzian width increasing from 200 MHz to 40 GHz. The influence of electron impact is discussed under these conditions and with 0-20 Torr of helium. Cascade amplified spontaneous emission is seen …

Importance Of Vegetation In Tsunami Mitigation: Evidence From Large Eddy Simulations With Fluid-Structure Interactions, Abhishek Mukherjee

Dissertations

Communities worldwide are increasingly interested in nature-based solutions like coastal forests for the mitigation of coastal risks. Still, it remains unclear how much protective benefit vegetation provides, particularly in the limit of highly energetic flows after tsunami impact. The present thesis, using a three-dimensional incompressible computational fluid dynamics model with a fluid-structure interaction approach, aims to quantify how energy reflection and dissipation vary with different degrees of rigidity and vegetation density of a coastal forest.

In this study, tree trunks are represented as cylinders, and the elastic modulus of hardwood trees such as pine or oak is used to characterize …

Large-Scale And Meso-Scale Ion Dynamics Of The Near-Earth Space Environment, Matthew Cooper

Dissertations

The mechanisms whereby low energy (order of lOs to 100s of eV) solar wind and ionosphere sourced particles are accelerated to high energy (order of 10s to 100s keV) in the Earth's magnetosphere are a trending research topic due to impacts on radiation belt populations, coupling to the high-latitude ionosphere, and energy budgets for collision-less plasma in dipole fields. Ultra-low frequency (ULF, order of 1-100 mHz) Alfven waves observed in the nightside inner magnetosphere during geomagnetic activity are one such acceleration mechanism. Several source processes for these waves, including the micro-scale drift-mirror mode, have been previously suggested but observational evidence …

Topics On Asymmetric Classification, Subhrasish Chakraborty

Dissertations

Asymmetric classification refers to a situation where the cost of misclassifying one class is significantly higher than the cost of misclassifying the other class. This problem is common in many real-world scenarios, such as medical diagnosis or fraud detection. In this dissertation two of the common types of asymmetric classification problems have been dealt with — imbalanced classification and ordinal classification. An example of imbalanced classification is to detect fraudulent credit card transactions where the distribution of the normal and fraud transactions are extremely skewed. On the other hand, ordinal classification, also known as ordinal regression, is widely used in …

Modelling Hoe Performance With An Extended Source; Experimental Investigation Using Misaligned Point Sources, Jorge Lasarte, Kevin Murphy, Izabela Naydenova, Jesús Atencia, Mª Victoria Collados, Suzanne Martin

Conference Papers

Holographic Optical Elements (HOEs) have the potential to enable more compact, versatile and lightweight optical designs, but many challenges remain. Volume HOE’s have the advantage of high diffraction efficiency but they present both chromatic selectivity and chromatic dispersion which impact on their use with wide spectrum light sources. Single-colour LED sources have a narrow spectrum that reduces these issues and this makes them better suited for use with volume HOEs. However, the LED source size must be taken into consideration for compact volume HOE-LED systems. To investigate the design limits for compact HOE-LED systems, a theoretical and experimental study was …

Molecular Simulations Of Mechanical Effects Of Adsorption In Gas And Liquid Phases, Alina Emelianova

Dissertations

Fluids adsorbing in nanoporous solids cause high pressures that affect the solids and the properties of the fluids themselves. This work explores the mechanical response of solids to the adsorption of gas and liquid. Chapter 1 outlines the current achievements in investigating the mechanical response of adsorbents to the adsorption process, specifically, the computational approaches to predict adsorption-induced deformation. Chapter 2 introduces the theoretical and computational methods employed in this work. Chapters 3-7 address the design and application of the computational techniques for such prediction in different systems: mesoporous silica, microporous zeolites, and metal-organic frameworks, and Chapter 8 focuses on …

Record High Room Temperature Resistance Switching In Ferroelectric-Gated Mott Transistors Unlocked By Interfacial Charge Engineering, Yifei Hao, Xuegang Chen, Le Zhang, Myung-Geun Han, Wei Wang, Yue-Wen Fang, Hanghui Chen, Yimei Zhu, Xia Hong

Department of Physics and Astronomy: Faculty Publications

The superior size and power scaling potential of ferroelectric-gated Mott transistors makes them promising building blocks for developing energyefficientmemory and logic applications in the post-Moore’s Law era. The close to metallic carrier density in the Mott channel, however, imposes the bottleneck for achieving substantial field effect modulation via a solid-state gate. Previous studies have focused on optimizing the thickness, charge mobility, and carrier density of single-layer correlated channels, which have only led to moderate resistance switching at room temperature. Here, we report a record high nonvolatile resistance switching ratio of 38,440% at 300 K in a prototype Mott transistor consisting …

Search For Heavy Resonances And Quantum Black Holes In Eμ, Eτ, And Μτ Final States In Proton-Proton Collisions At √S = 13 Tev, A. Tumasyan

Department of Physics and Astronomy: Faculty Publications

A search is reported for heavy resonances and quantum black holes decaying into eμ, eτ, and μτ final states in proton-proton collision data recorded by the CMS experiment at the CERN LHC during 2016–2018 at √s = 13TeV, corresponding to an integrated luminosity of 138 fb⁻¹. The eμ, eτ, and μτ invariant mass spectra are reconstructed, and no evidence is found for physics beyond the standard model. Upper limits are set at 95% confidence level on the product of the cross section and branching fraction for lepton flavor violating signals. Three benchmark signals are studied: resonant τ sneutrino …

Vibrational, Rotational And Electronic Spectroscopy For Possible Interstellar Detection Of Alnh2 And Halnh, Tarek Trabelsi, Vincent J. Esposito, Joseph S. Francisco

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

We obtained accurate vibrational frequencies, rotational constants, and vertical transition energy for AlNH₂(X¹A₁) and HAlNH(X¹A′) isomers using ab initio calculations at various levels of theory. These two isomers are potential candidates for astronomical observation. AlNH₂ and HAlNH are thermodynamically stable, with Al-NH₂ and HAl-NH bond dissociation energies predicted to be 4.39 and 3.60 eV, respectively. The two isomers are characterized by sizable dipole moments of 1.211 and 3.64 D, respectively. The anharmonic frequencies and spectroscopic constants reported for the two isomers should facilitate their experimental differentiation. In addition, we evaluated …

Symmetry Control Of Unconventional Spin–Orbit Torques In Iro2, Michael Patton, Gautam Gurung, Ding-Fu Shao, Gahee Noh, Joseph A. Mittelstaedt, Marcel Mazur, Jong-Woo Kim, Philip J. Ryan, Evgeny Y. Tsymbal, Si-Young Choi, Daniel C. Ralph, Mark S. Rzchowski, Tianxiang Nan, Chang-Beom Eom

Department of Physics and Astronomy: Faculty Publications

Spin–orbit torques generated by a spin current are key to magnetic switching in spintronic applications. The polarization of the spin current dictates the direction of switching required for energy-efficient devices. Conventionally, the polarizations of these spin currents are restricted to be along a certain direction due to the symmetry of the material allowing only for efficient in-plane magnetic switching. Unconventional spin–orbit torques arising from novel spin current polarizations, however, have the potential to switch other magnetization orientations such as perpendicular magnetic anisotropy, which is desired for higher density spintronic-based memory devices. Here, it is demonstrated that low crystalline symmetry is …

Antibacterial And Cytocompatible Ph-Responsive Peptide Hydrogel, Dona I. Edirisinghe, Areetha D'Souza, Maryam Ramezani, Robert J. Carroll, Quenten Chicón, Cheyene L. Muenzel, Jonathan Soule, Mary B. Monroe, Alison E. Patteson, Olga V. Makhlynets

Physics - All Scholarship

A short peptide, FHHF-11, was designed to change stiffness as a function of pH due to changing degree of protonation of histidines. As pH changes in the physiologically relevant range, G′ was measured at 0 Pa (pH 6) and 50,000 Pa (pH 8). This peptide-based hydrogel is antimicrobial and cytocompatible with skin cells (fibroblasts). It was demonstrated that the incorporation of unnatural AzAla tryptophan analog residue improves the antimicrobial properties of the hydrogel. The material developed can have a practical application and be a paradigm shift in the approach to wound treatment, and it will improve healing outcomes for millions …

Filaments And Their Application To Air Lasing, Spectroscopy, And Guided Discharge, Ali Rastegari

Optical Science and Engineering ETDs

Laser filamentation is a fascinating phenomenon that occurs when an intense laser beam travels through transparent materials, in particular air. At sufficiently high power (TW in the near IR, GW in the UV), instead of spreading out like a regular laser beam, something remarkable happens: the laser beam becomes tightly focused, creating a thin and intense column of light called a laser filament. Laser filamentation is characterized by two main properties: (I) a high-intensity core that remains narrow over long distances beyond the Rayleigh range and (II) a low-density plasma channel within the core. In recent years, laser filamentation has …

Ceers Key Paper. V. Galaxies At 4 < Z < 9 Are Bluer Than They Appear-Characterizing Galaxy Stellar Populations From Rest-Frame ∼1 Μm Imaging, Casey Papovich, Justin W. Cole, Guang Yang, Steven L. Finkelstein, Guillermo Barro, Véronique Buat, Denis Burgarella, Pablo G. Pérez-González, Paola Santini, Lise-Marie Seillé, Lu Shen, Pablo Arrabal Haro, Micaela B. Bagley, Eric F. Bell, Laura Bisigello, Antonello Calabrò, Caitlin M. Casey, Marco Castellano, Katherine Chworowsky, Nikko J. Cleri, Luca Costantin, M. C. Cooper

Pacific Faculty Work

We present results from the Cosmic Evolution Early Release Survey on the stellar population parameters for 28 galaxies with redshifts 4 < z < 9 using imaging data from the James Webb Space Telescope (JWST) Mid-Infrared Instrument (MIRI) combined with data from the Hubble Space Telescope and the Spitzer Space Telescope. The JWST/MIRI 5.6 and 7.7 μm data extend the coverage of the rest-frame spectral energy distribution to nearly 1 μm for galaxies in this redshift range. By modeling the galaxies’ SEDs the MIRI data show that the galaxies have, on average, rest-frame UV (1600 Å)—I-band colors 0.4 mag bluer than derived when using photometry that lacks MIRI. Therefore, the galaxies have lower ratios of stellar mass to light. The MIRI data reduce the stellar masses by 〈 Δ log M * 〉 = 0.25 dex at 4 < z < 6 and 0.37 dex at 6 < z < 9. This also reduces the star formation rates (SFRs) by 〈ΔlogSFR〉 = 0.14 dex at 4 < z < 6 and 0.27 dex at 6 < z < 9. The MIRI data also improve constraints on the allowable stellar mass formed in early star formation. We model this using a star formation history that includes both a “burst” at z f = 100 and a slowly varying (“delayed-τ”) model. The MIRI data reduce the allowable stellar mass by 0.6 dex at 4 < z < 6 and by ≈1 dex at 6 < z < 9. Applying these results globally, this reduces the cosmic stellar-mass density by an order of magnitude in the early Universe (z ≈ 9). Therefore, observations of rest-frame ≳1 μm are paramount for constraining the stellar-mass buildup in galaxies at very high redshifts.

Design And Implementation Of Montmorillonite Clay-Based Catalyst For Carbon Nanotube Synthesizing, Mohamed Morsy

Nanotechnology Research Centre

No abstract provided.

Tardys Quantifiers: Extracting Temporal And Reversible Dynamical Symmetries, Nhat Vu Minh Nguyen, Arjendu K. Pattanayak, Andres Aragoneses

2023 Symposium

One of the great challenges in complex and chaotic dynamics is to reveal the details of its underlying determinism. This can be manifest in the form of temporal correlations or structured patterns in the dynamics of a measurable variable. These temporal dynamical structures are sometimes a consequence of hidden global symmetries. Here we identify the temporal (approximate) symmetries of a semiconductor laser with external optical feedback, based on which we define the Temporal And Reversible DYnamical Symmetry (TARDYS) quantifiers to evaluate the relevance of specific temporal correlations in a time series. We show that these symmetries are also present in …

Synthesis And Functional Properties Of La2fecro6 Based Nanostructures, Mohamed Morsy

Nanotechnology Research Centre

No abstract provided.

Experiments And Data Analysis For Modulated Phase Gratings In X-Rays, Sydney B. Carr

LSU Master's Theses

Purpose: Modulated Phase Grating (MPG) interferometry has been shown in theory and simulations to produce observable fringes on a clinical detector without requiring fluence absorbing analyzer. In this work, we will experimentally show that the MPG X-ray system produces observable fringes and multi-modal X-ray images.

Motivation:Nearly 1 in 8 women in the US will develop invasive breast cancer in their lifetime, accounting for approximately 40,000 deaths each year [1-2]. In order to pursue the best treatment option available, cancer itself must be adequately imaged and staged, based on size and level of metastasis, on the order of Stage I-IV. …

Human And Technical Factors In The Adoption Of Quantum Cryptographic Algorithms, Alyssa Pinkston

Mathematical Sciences Technical Reports (MSTR)

The purpose of this research is to understand what factors would cause users to choose quantum key distribution (QKD) over other methods of cryptography. An Advanced Encryption Standard (AES) key can be exchanged through communication using the Rivest, Shamir, Adleman (RSA) cryptographic algorithm, QKD, or post-quantum cryptography (PQC). QKD relies on quantum physics where RSA and PQC use complex mathematics to encrypt data. The BB84 quantum cryptographic protocol involves communication over a quantum channel and a public channel. The quantum channel can be technically attacked by beamsplitting or intercept/resend. QKD, like other forms of cryptography, is vulnerable to social attacks …

Ultrafast Electron Diffraction Instrument For Gas And Condensed Matter Samples, Yibo Wang, Sajib Kumar Saha, Tianlin Li, Yanwei Xiong, Kyle Wilkin, Anil Adhikari, Michael Loes, Jehad Abourahma, Xia Hong, S. Adenwalla, Alexander Sinitskii, Martin Centurion

Department of Physics and Astronomy: Faculty Publications

We report the modification of a gas phase ultrafast electron diffraction (UED) instrument that enables experiments with both gas and condensed matter targets, where a time-resolved experiment with sub-picosecond resolution is demonstrated with solid state samples. The instrument relies on a hybrid DC-RF acceleration structure to deliver femtosecond electron pulses on the target, which is synchronized with femtosecond laser pulses. The laser pulses and electron pulses are used to excite the sample and to probe the structural dynamics, respectively. The new system is added with capabilities to perform transmission UED on thin solid samples. It allows for cooling samples to …

Aharonov–Bohm Effect With An Effective Complex-Valued Vector Potential, Ismael L. Paiva, Yakir Aharonov, Jeff Tollaksen, Mordecai Waegell

Mathematics, Physics, and Computer Science Faculty Articles and Research

The interaction between a quantum charge and a dynamic source of a magnetic field is considered in the Aharonov–Bohm (AB) scenario. It is shown that, in weak interactions with a post-selection of the source, the effective vector potential is, generally, complex-valued. This leads to new experimental protocols to detect the AB phase before the source is fully encircled. While this does not necessarily change the nonlocal status of the AB effect, it brings new insights into it. Moreover, we discuss how these results might have consequences for the correspondence principle, making complex vector potentials relevant to the study of classical …

Néel Spin Currents In Antiferromagnets, Ding-Fu Shao, Yuan-Yuan Jiang, Jun Ding, Shu-Hui Zhang, Zi-An Wang, Rui-Chun Xiao, Gautam Gurung, W. J. Lu, Y. P. Sun, Evgeny Y. Tsymbal

Department of Physics and Astronomy: Faculty Publications

Ferromagnets are known to support spin-polarized currents that control various spin-dependent transport phenomena useful for spintronics. On the contrary, fully compensated antiferromagnets are expected to support only globally spin-neutral currents. Here, we demonstrate that these globally spin-neutral currents can represent the Néel spin currents, i.e., staggered spin currents flowing through different magnetic sublattices. The Néel spin currents emerge in antiferromagnets with strong intrasublattice coupling (hopping) and drive the spin-dependent transport phenomena such as tunneling magnetoresistance (TMR) and spin-transfer torque (STT) in antiferromagnetic tunnel junctions (AFMTJs). Using RuO₂ and Fe₄GeTe₂ as representative antiferromagnets, we predict that the …

Multimessenger Observations Of Double Neutron Stars In The Galactic Disk With Gravitational And Radio Waves, Wen-Fan Feng, Jie-Wen Chen, Yan Wang, Soumya D. Mohanty, Yong Shao

Physics & Astronomy Faculty Publications

We evaluate the prospects for radio follow-up of the double neutron stars (DNSs) in the Galactic disk that could be detected through future space-borne gravitational wave (GW) detectors. We first simulate the DNS population in the Galactic disk that is accessible to space-borne GW detectors according to the merger rate from recent LIGO results. Using the inspiraling waveform for the eccentric binary, the average number of the DNSs detectable by TianQin (TQ), LISA, and TQ+LISA are 217, 368, and 429, respectively. For the joint GW detection of TQ+LISA, the forecasted parameter estimation accuracies, based on the Fisher information matrix, for …

Reconstruction Of Volumetric Modulated Arc Therapy-Computed Tomography, Chia-Lung Chien

LSU Doctoral Dissertations

Purpose: Volumetric modulated arc therapy-computed tomography (VMAT-CT) was proposed in 2010 as the CBCT reconstruction technique using portal images collected during VMAT. Yet, its clinical applications were impeded by the poor image quality due to motion blurs from fast movements of multi-leaf collimator (MLC) and projection data deficiency due to truncations from MLC. The goal of this study is to develop systematic preprocessing methods, and a novel iterative reconstruction algorithm to generate quality VMAT-CT and lower the number of failure cases of VMAT-CT reconstruction.

Methods: Systematic image preprocessing methods, including Online region-based active contouring (ORACM), MLC motion modeling and outlier …

Using Deep Neural Networks To Classify Astronomical Images, Andrew D. Macpherson

Honors Projects

As the quantity of astronomical data available continues to exceed the resources available for analysis, recent advances in artificial intelligence encourage the development of automated classification tools. This paper lays out a framework for constructing a deep neural network capable of classifying individual astronomical images by describing techniques to extract and label these objects from large images.

Photoisomerizable Membrane Active Peptides, Cristina Ventura

Seton Hall University Dissertations and Theses (ETDs)

Membrane active peptides (MAPs) bind and partition into the cell membrane thus causing permeabilization. Many α-helical membrane active peptides contain central proline residues that distinguish the hydrophobic and hydrophilic faces of the helix. The proline induces a bend that produces a helix-hinge-helix motif. Mutation of these proline residues has a significant effect on the activity of the MAP. Azobenzene is a photoisomerizable molecule that switches from its trans to cis isomer upon excitation with ultraviolet (UV) light and from its cis to trans isomer upon excitation with visible light (VL). In this work it is hypothesized that the hinge function …

Effective Nanomembranes From Chitosan/Pva Blend Decorated Graphene Oxide With Gum Rosin And Silver Nanoparticles For Removal Of Heavy Metals And Microbes From Water Resources, Mohamed Morsy

Nanotechnology Research Centre

No abstract provided.

Maximum Likelihood Estimation Of Glandular Fraction For Mammography, Bryce Smith

LSU Master's Theses

Breast tissue is a mixture of adipose and fibro glandular tissue with a glandular fraction on average of 20%-30%. Previous studies have confirmed that there is a risk of undetected breast cancer related to the amount of glandular tissue present in the breast. Since a higher glandular fraction can lead to an increased cancer risk, it is important for radiologists to know quantitative glandular fraction when diagnosing a patient. Another increasingly popular protocol for mammography is to eliminate the anti-scatter grid and use software algorithms to reduce scatter. This work focuses on using a maximum likelihood algorithm to estimate the …

Rehybridization Dynamics Into The Pericyclic Minimum Of An Electrocyclic Reaction Imaged In Real-Time, Y. Liu, D. M. Sanchez, M. R. Ware, E. G. Champenois, J. Yang, J. P. F. Nunes, A. Attar, Martin Centurion, J. P. Cryan, R. Forbes, K. Hegazy, M. C. Hoffmann, F. Ji, M.-F. Lin, D. Luo, S. K. Saha, X. Shen, X. J. Wang, T. J. Martínez, T. J. A. Wolf

Department of Physics and Astronomy: Faculty Publications

Electrocyclic reactions are characterized by the concerted formation and cleavage of both σ and π bonds through a cyclic structure. This structure is known as a pericyclic transition state for thermal reactions and a pericyclic minimum in the excited state for photochemical reactions. However, the structure of the pericyclic geometry has yet to be observed experimentally.We use a combination of ultrafast electron diffraction and excited state wavepacket simulations to image structural dynamics through the pericyclic minimum of a photochemical electrocyclic ring-opening reaction in the molecule α-terpinene. The structural motion into the pericyclic minimum is dominated by rehybridization of two carbon …