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Full-Text Articles in Entire DC Network
Continuous Symmetry Discovery And Enforcement Using Vector Fields With Application To Time Series And Image Data, Benjamin D. Shaw
Continuous Symmetry Discovery And Enforcement Using Vector Fields With Application To Time Series And Image Data, Benjamin D. Shaw
All Graduate Theses and Dissertations, Fall 2023 to Present
Machine learning powers many technologies we use every day, from image classification in computer vision to analyzing time series data such as sensor readings or financial trends. One way to make these systems smarter and more reliable is by using symmetry, meaning patterns that remain unchanged under certain transformations, such as rotations for images or uniform changes in signal amplitude for time series. Discovering these patterns can improve understanding of data and help build models that perform well in new situations.
Current methods for finding symmetry often rely on large neural networks and are limited to simple transformations like stretching …
Social And Institutional Factors Influencing Restoration Decisions In Sagebrush Plant Communities In The Great Basin, Carmen Calzado-Martínez
Social And Institutional Factors Influencing Restoration Decisions In Sagebrush Plant Communities In The Great Basin, Carmen Calzado-Martínez
All Graduate Theses and Dissertations, Fall 2023 to Present
Sagebrush landscapes of the Great Basin in the western United States have changed dramatically over the past century. Invasive grasses, repeated wildfires, and past land-use practices have made it increasingly difficult for native plant communities to recover once they are damaged. Most restoration efforts occur after disturbances such as wildfire, when ecosystems may already be severely degraded. An alternative approach is proactive restoration, which aims to strengthen ecosystems before major damage occurs.
This dissertation examines whether proactive restoration strategies could realistically be used in sagebrush rangelands and what factors influence their adoption. The research combines three complementary approaches. First, interviews …
Rainbow Dominating Sets Of Graphs, Samuel L. Powell
Rainbow Dominating Sets Of Graphs, Samuel L. Powell
All Graduate Theses and Dissertations, Fall 2023 to Present
The content of this thesis may be compared to a stack of plates with a common design that are broken, one at a time. If the plates are broken into large enough pieces you would be able to choose one fragment from each broken plate to discover the entire design that the plates share. For example, if you were still missing the center of the design after taking a piece from some plates, you could look for the piece of the next broken plate with the region in question.
We study the question of how many broken plates might guarantee …
Scalable Roof Polygon Extraction And Geometric Characterization From Remotely-Sensed Data For Snow Load Assessment, Jashon Newlun
Scalable Roof Polygon Extraction And Geometric Characterization From Remotely-Sensed Data For Snow Load Assessment, Jashon Newlun
All Graduate Theses and Dissertations, Fall 2023 to Present
Heavy snow accumulation on rooftops is a serious structural risk in cold climates, and understanding how much snow builds up on different types of roofs is essential for safe building design. Currently, most data on roof snow loads comes from small, labor-intensive field surveys that cover only a handful of buildings at a time. This results in far too few measurements of buildings to draw confident conclusions about how snow behaves across communities. This thesis develops and demonstrates a new automated approach for measuring roof snow accumulation and extracting key building characteristics across thousands of buildings at once using airborne …
A Novel Approach To Creativity Assessment: Forced Pairwise Ranking With Large Language Models, Phillip R. Gregory Jr
A Novel Approach To Creativity Assessment: Forced Pairwise Ranking With Large Language Models, Phillip R. Gregory Jr
Master's Theses
Assessing creativity at scale remains a persistent challenge in cognitive science, as human raters are costly, slow, and often inconsistent in their judgments. This thesis introduced a novel framework for automated scientific creativity assessment using forced pairwise ranking, in which fine-tuned large language models compared response pairs and determined which was more creative. Five empirical studies were conducted using Llama-2-7B and Llama-2-13B models adapted via LoRA fine-tuning and benchmarked against human scored responses from the Scientific Creative Thinking Test. A regression baseline achieved Pearson �� = .74 on the test set, matching the human inter-rater ceiling reported in the literature. …
Examining Student Practices In A Technology-Mediated Math Classroom, Bradley T. Dodd
Examining Student Practices In A Technology-Mediated Math Classroom, Bradley T. Dodd
Electronic Theses, Projects, and Dissertations
It is important for math educators to make sense of student thinking in the classroom. Without opportunities to practice this skill math educators struggle to improve, particularly when students are engaging in mathematics using technology. As such, there is a need for video artifacts of students engaging with mathematics using technology for use in professional development activities (Lovett 2020). In accordance with Lovett et al.'s (2020) design principles for examining student practices in a technology-mediated environment, I carried out a study to determine whether these artifacts of student work could be created working with college undergraduates as participants. Students engaged …
A New Approach To Generate Combinatorial Patterns In Logical Analysis Of Data And Its Application To Predict College Retention, Salihah Ahmed E. Jaafari
A New Approach To Generate Combinatorial Patterns In Logical Analysis Of Data And Its Application To Predict College Retention, Salihah Ahmed E. Jaafari
Theses and Dissertations
Student retention and degree completion remain central challenges for higher-education institutions, with significant implications for student success, institutional effectiveness, and public accountability. While advances in predictive analytics have enabled earlier identification of students at risk of withdrawal, many commonly used machine learning approaches suffer from limited interpretability, constraining their practical usefulness for advising, intervention, and policy decision making. This dissertation addresses the problem of predicting student persistence by developing and evaluating optimization based, interpretable classification models within the Logical Analysis of Data (LAD) framework. Building on existing LAD formulations, this research introduces two novel pattern generation models, the Best Term …
Mechanism Of Formation Of Guanine-Guanine Crosslinks As Products Of One-Electron Oxidation Of 1-Methylguanosine In Acidic Medium, Ibrahim Braimah Mr
Mechanism Of Formation Of Guanine-Guanine Crosslinks As Products Of One-Electron Oxidation Of 1-Methylguanosine In Acidic Medium, Ibrahim Braimah Mr
Electronic Theses and Dissertations
Reactive oxygen species (ROS) from normal metabolism and environmental exposure may cause oxidative DNA damage. Guanine (G) is the most oxidizable nucleobase. One-electron oxidation (OEO) of G in produces guanine radical cation (G•⁺), which deprotonates to form guanyl radical G(-H)•.This radical exists in two tautomeric forms: G(N1-H)• and G(N2-H)•. Dimerization of guanyl radical yields G-G cross-links (D1/D2); a tautomeric form for dimer formation remains elusive. This study presents the first characterization of G• dimerization products from the OEO of 1-MeGuo in acidic medium. Photolysis at 470 nm in the presence of S₂O₈²⁻ and Ru(II)(bpy)₃²⁺ generates two major stereoisomers (D1AW* and …
Provenance Analysis Of Advanced Persistent Threats In Operational Technology Environments, Laura Aminta Guevara
Provenance Analysis Of Advanced Persistent Threats In Operational Technology Environments, Laura Aminta Guevara
Open Access Theses & Dissertations
Live vulnerability testing and penetration assessments of critical infrastructure are costly, complex operationally and, in many cases, unsafe to conduct directly against live systems, whether these are commissioned in-house and through third-party providers. For Operational Technology environments specifically, these constraints are further aggravated by the limited vendor support and inconsistent security patching available that characterize many industrial communication protocols. This significantly restricts the scope and feasibility of conventional penetration testing. At the same time, the increasing overlapping of OT systems with enterprise networks and the internet has expanded the attack surface of ICS infrastructure, making more pressing the need for …
Numerical Methods For Modeling Darcy-Forchheimer Flow In Heterogeneous Porous Media, Nate Mcnair
Numerical Methods For Modeling Darcy-Forchheimer Flow In Heterogeneous Porous Media, Nate Mcnair
Open Access Theses & Dissertations
Classic approaches to modeling fluid flow in porous media rely on Darcy's Law, which assumes a linear relationship between volumetric flow rate and the pressure gradient. However, in recent years, applications such as enhanced geothermal systems have highlighted the need to model nonlinear flow behavior, since experimental and observational data show that, once flow velocity exceeds a certain threshold, the relationship between velocity and macroscopic pressure gradient becomes nonlinear. This requires alternative models that more accurately capture the physical behavior of these systems.The Darcy-Forchheimer model provides one such alternative by introducing a nonlinear velocity-pressure relationship. However, this nonlinearity creates additional …
An Ordinal Categorical Data Analysis Using The Stereotype Model Within A Bayesian Framework With A Logistic-Normal Prior, Nathaniel A. Sakyi
An Ordinal Categorical Data Analysis Using The Stereotype Model Within A Bayesian Framework With A Logistic-Normal Prior, Nathaniel A. Sakyi
Open Access Theses & Dissertations
Ordinal categorical data are pervasive in applied research, yet their analysis is often compromised by modeling strategies that implicitly assume equidistant category spacing or impose restrictive structural constraints. Metric regression models and latent-variable threshold approaches routinely misrepresent ordinal information, leading to biased inference, distorted uncertainty quantification, and loss of structural insight. This paper develops a Bayesian framework for ordinal regression that explicitly accommodates \textbf{unequal spacing among ordered response categories} while preserving ordinal structure and interpretability.
The proposed approach builds on the stereotype regression model, which embeds ordinal categories into a latent one-dimensional continuum through estimable score parameters. While the stereotype …
Singularity-Enriched Neural Networks For Elliptic Problems In Polygonal Domains, Harshini Reddy Kodiganti
Singularity-Enriched Neural Networks For Elliptic Problems In Polygonal Domains, Harshini Reddy Kodiganti
Open Access Theses & Dissertations
This thesis develops and analyzes neural-network-based solvers for the Poisson equation on polygonal domains, where re-entrant corners induce reduced solution regularity and challenge standard numerical methods.
Three neural formulations are investigated: Physics-Informed Neural Networks (PINNs), Physics-Informed Extreme Learning Machines (PIELMs), and Rank-Inspired Neural Networks (RINNs). PINNs rely on gradient-based optimization with automatic differentiation, while PIELMs employ randomly initialized hidden features with least-squares training, achieving significantly lower computational cost. RINNs extend this framework through covariance-driven orthogonalization to improve numerical conditioning and stability.
On convex polygonal domains, all three methods are benchmarked against analytical solutions. Both PIELM and RINN consistently achieve higher …
Design And Simulation Of Anti-Resonant Hollow-Core Fiber For Sensing Applications, Pravallika Kante
Design And Simulation Of Anti-Resonant Hollow-Core Fiber For Sensing Applications, Pravallika Kante
Theses and Dissertations
This thesis presents the design and simulation of an 8-tube single-ring anti-resonant hollow-core fiber for sensing applications, with particular emphasis on methane gas detection at the fundamental absorption wavelength of 3.3 µm. Conventional solid-core silica optical fibers exhibit strong multi-phonon material absorption beyond 2.5 µm, rendering them fundamentally unsuitable for efficient light guidance and direct gas sensing at mid-infrared wavelengths. Anti-resonant hollow-core fibers overcome this limitation by guiding light predominantly through an air-filled hollow core via the anti-resonant reflecting optical waveguide mechanism, in which the thin silica glass walls of the cladding tubes act as Fabry-Pérot etalons that confine the …
X-Raying The Material Surrounding Active Supermassive Black Holes, Isaiah S. Cox
X-Raying The Material Surrounding Active Supermassive Black Holes, Isaiah S. Cox
All Dissertations
It is important to understand the nature of the gas and dust immediately surrounding the supermassive black hole (SMBH) in active galactic nuclei (AGN), because this material feeds the accretion disk and couples the activities going on at the AGN scale to the host galaxy. However, there remain large uncertainties on basic properties about this material such as its location and distribution. This is primarily due to the difficulties in resolving spatial information on these scales at extragalactic distances.
AGN emit a tremendous amount of radiation all across the electromagnetic spectrum, including X-rays. The X-rays come from a very small …
Redeveloping Mississippi: A Case Study On Brownfields In Central & Southern Mississippi, Sahrah R. Yeroozedek
Redeveloping Mississippi: A Case Study On Brownfields In Central & Southern Mississippi, Sahrah R. Yeroozedek
Master's Theses
Brownfields, or properties that are or possibly are contaminated with dangerous materials, represent a common obstacle for communities in Mississippi. The real or potential presence of contaminants at these sites often deters investors due to costly cleanup requirements (EPA, n.d. -b). The Environmental Protection Agency (EPA), through its Brownfield Revitalization Program, implemented guidelines for covering the costs and labor associated with the remediation of these properties. The EPA is not, however, responsible for redevelopment that supports long-term environmental and economic sustainability. Although the EPA maintains inventories of all Brownfields, there is also no comprehensive database of Brownfields and their current …
Grazed Pasture Effects On Greenhouse Gas Emissions In The Ozark Highlands, Tyler Buchanan
Grazed Pasture Effects On Greenhouse Gas Emissions In The Ozark Highlands, Tyler Buchanan
Graduate Theses and Dissertations
In the United States (US), grazinglands serve as the main foundation for the livestock industry, and, in Arkansas specifically, pastures are essential for rotational grazing and dairy operations. Climate change is increasingly becoming a concern in the agriculture industry, largely caused by anthropogenic activities increasing greenhouse gas (GHG) concentrations in the atmosphere, at least partly due to the nutrient recycling that occurs from animal manure additions in grazinglands. Therefore, quantifying GHG emissions from pastures is essential to better understanding the impacts of grazing on the environment. The objective of this study was to quantify and evaluate the potential effects of …
Microplastic Composition And Exposure Pathways In Freshwater Systems: A Multi-Matrix Comparison Between Streams And Retention Ponds In Hamilton County, In, Mya Whaley
All-Inclusive List of Electronic Theses and Dissertations
Since the early 1900s, the use of plastics has increased exponentially. The breakdown of plastic materials has exposed all ecosystems to microplastics (small particles of plastic < 5 mm), which are now ubiquitous in natural settings. Microplastics have a relatively large surface area, and many chemicals adsorb to these small particles, impacting their fate and transport of pollution. While microplastics have been found in virtually every setting on Earth, research is necessary to understand their impact on freshwater ecosystems and biogeochemical cycles. The focus of this research was to investigate microplastic compositions in crayfish, sediments, and water samples collected in streams and retention ponds. We analyzed trends in microplastic counts across different land-cover classes, waterbody types, and species, and compared concentrations among matrices to improve our understanding of microplastic exposure pathways in freshwater ecosystems. As a secondary objective, lead and arsenic concentrations were analyzed from sediment samples to investigate metal burdens and compare them to microplastic concentrations. Our findings revealed that, in general, urban streams had the highest microplastic concentrations within land cover categories, and retention ponds had higher microplastic counts than streams. Crayfish, such as F. rusticus had higher microplastic concentrations than F. virilis and F. propinquus, although these results may be influenced by study design. The most common microplastic type was fibers, and most common color was transparent. There was no significant correlation between microplastic and metal concentrations in sediments. We found crayfish to be adequate bioindicators of microplastic pollution, because they were less impacted by environmental variability than sediment and water samples. This research presents the first evidence of microplastics in our study species, F. propinquus, F. rusticus, and F. virlis. This work presents new evidence of microplastic accumulation in crayfish, sediments, and water from freshwater systems in the Midwestern United States. Microplastics were found in every sample type—crayfish, water, and sediment—across urban, rural, and forested landscapes, highlighting their pervasive distribution. The findings provide foundational data for assessing emerging ecological and human-health risks and emphasize the importance of sustained monitoring and research on MP contamination in freshwater environments.
Integrated Geophysical, Geotechnical, And Mineralogical Characterization Of Expansive Weches Formation Soils In East Texas: Implications For Infrastructure Design, Samuel Annobil
Electronic Theses and Dissertations
This study investigates the geotechnical, geophysical, and mineralogical characteristics of soils derived from the Weches Formation in Nacogdoches County, East Texas, with emphasis on the relationships among electrical resistivity, moisture condition, compaction state, and mineralogical composition. The Weches Formation is well known for producing clay-rich, moisture-sensitive soils that pose challenges to subgrade performance because of their plasticity and swelling behavior. Representative soil samples were collected and subjected to laboratory testing, including particle size analysis, Atterberg limits, Standard Proctor compaction, free swell tests, electrical resistivity measurements, and X-ray diffraction (XRD) mineralogical analysis. The soils are predominantly fine-grained and clay-rich, with USCS …
Final Silver Bow Creek Conservation Area Materials Management Plan, Pioneer Technical Services, Inc.
Final Silver Bow Creek Conservation Area Materials Management Plan, Pioneer Technical Services, Inc.
Silver Bow Creek/Butte Area Superfund Site
No abstract provided.
Hybrid Machine Learning For Zero-Day Malware Detection: An Adaptive Static-Dynamic Analysis Approach, Garrett Farmer
Hybrid Machine Learning For Zero-Day Malware Detection: An Adaptive Static-Dynamic Analysis Approach, Garrett Farmer
Theses and Dissertations
In an era of swiftly evolving cyber threats, zero-day malware continues to be one of the most challenging classes of attacks to detect and mitigate. Traditional signature-based methods often fail to detect novel malicious code, leaving institutions vulnerable to unknown exploits. This thesis proposes a machine learning (ML)-based framework that is designed to detect unknown malware variants. By combining both static and dynamic techniques, such as file structure exam ination and sandbox-based runtime analysis, this approach aims to successfully capture malicious characteristics. The proposed custom pipeline addresses the computational overhead that is associ ated with deep inspections, outlining a staged …
On The Structure Of The Homotopy Lie Algebra Of Local Rings, Dawson M. Strong
On The Structure Of The Homotopy Lie Algebra Of Local Rings, Dawson M. Strong
Theses and Dissertations
This thesis investigates the construction and homological properties of the homotopy Lie algebra π(R) of a commutative local ring (R,m,k). Drawing upon the theoretical framework of differential graded (DG) algebras, we first establish the theory of minimal free resolutions and other standard topics in homological algebra. The core of this work details the iterative construction of the acyclic closure R⟨Y⟩ of k over R, which is achieved by the systematic adjunction of exterior and divided power variables to eliminate cycles in homology. We demonstrate that this acyclic closure serves as a minimal free resolution and provides the means to define …
Assessment Of Mississippi Landfill Capacity In Relation To Waste Generation And Land-Use Constraints, Jason C. Anderson
Assessment Of Mississippi Landfill Capacity In Relation To Waste Generation And Land-Use Constraints, Jason C. Anderson
Master's Theses
Municipal solid waste (MSW) management presents a growing challenge in Mississippi as population trends, socioeconomic change and regional development continue to place pressure on existing landfill capacity. This thesis examines waste generation and disposal patterns from 2000 through 2022 across Mississippi counties, with projections extending to 2050. Historical landfill tonnage data was gathered and compiled from the Mississippi Department of Environmental Quality (MDEQ) and analyzed using regression models in Excel and RStudio, with forecasts generated for both in-state and out-of-state waste flow. Results highlight significant variations among landfills, including differing closure timelines, changing county service areas and notable shifts in …
The Impact Of Community On Professional Identity In Computer Science Education, Ian A. Kollipara
The Impact Of Community On Professional Identity In Computer Science Education, Ian A. Kollipara
School of Computing: Dissertations, Theses, and Student Research
This thesis explores the application of Communities of Practice (CoPs) in Computer Science Education. The work consists of two qualitative studies examining related but distinct populations: (1) K–12 CS teachers and (2) undergraduate CS students. The first study presents a retrospective analysis of conneCTION, an online CoP for K–12 CS educators, identifying strengths, weaknesses, and design considerations that inform future platform development. The second study investigates how participation in a CoP can mitigate negative and exclusionary stereotypes in CS. This study was conducted in an under-explored context: a small, private, religious, Midwestern university, and examines an existing community, the Programming …
Discrete-Event Simulation: A Leslie System Model For Transportation Demography, Md Zobaer Ahammad
Discrete-Event Simulation: A Leslie System Model For Transportation Demography, Md Zobaer Ahammad
Electronic Theses and Dissertations
Transportation systems are influenced by demographic change, household formation,and patterns of vehicle ownership. These factors affect long-run transportation demand and congestion levels within urban infrastructure. Understanding how demographic dynamics interact with transportation behavior is therefore important for analyzing the long-term evolution of transportation systems. This thesis develops a modeling framework that integrates discrete-event simulation with a Leslie-type matrix model to study transportation–demography interactions.Simulation outputs are aggregated to construct a transition matrix describing changes in transportation states. This matrix acts as a linear (or affine) transformation on the transportation state vector, allowing the system to be analyzed as a discrete linear …
Machine-Learning Landslide Susceptibility And Runout Modeling In The Nolichucky River Gorge After Hurricane Helene, Grace Braver
Machine-Learning Landslide Susceptibility And Runout Modeling In The Nolichucky River Gorge After Hurricane Helene, Grace Braver
Electronic Theses and Dissertations
Extreme rainfall from Hurricane Helene (September 2024) triggered widespread landslides across the southern Appalachian region, highlighting the need for rapid landslide susceptibility assessments that capture both landslide initiation and downstream runout. Traditional susceptibility models often focus solely on initiation zones, limiting their ability to identify which slopes will generate destructive landslides or where material will travel. This study addresses that gap by (1) integrating Geographic Information System (GIS)-based machine learning susceptibility modeling using ArcGIS Pro: Maximum Entropy (MaxEnt) and Random Forest-Based and Boosted Classification and Regression (FBBC) and (2) the U.S. Geological Survey (USGS) Grfin (Growth, Flow, and Inundation) runout …
Genre Prediction Using Rnns And Llm-Enhanced Video Game Review Data, Gabriel Young
Genre Prediction Using Rnns And Llm-Enhanced Video Game Review Data, Gabriel Young
Graduate Theses and Dissertations
LLMs (Large Language Models) are powerful tools for engaging with textual data, carrying many advantages over classical NLP (Natural Language Processing) and ML (Machine Learning) approaches. However, a classical ML model can still be faster, more efficient to run, and accessible than an LLM. We seek to gain the benefits of LLM text comprehension and preserve them in a classical ML model, a hybrid approach. The LLM operates on text to surface relevant information and associations in our problem space, then the ML model trains on the LLM output. The model may learn from the LLM and provide a more …
Structural Relaxation In Glass-Forming Liquids At Extreme Pressure: Photon-Correlation Spectroscopy And Constrained Thermodynamic Surface Modeling, Kevin Wayne Lyon
Structural Relaxation In Glass-Forming Liquids At Extreme Pressure: Photon-Correlation Spectroscopy And Constrained Thermodynamic Surface Modeling, Kevin Wayne Lyon
Graduate Theses and Dissertations
Structural relaxation in glass-forming liquids is strongly dependent on both temperature and pressure, yet direct measurement of structural α-relaxation under multi-gigapascal compression has remained experimentally challenging. This work extends depolarized photon correlation spectroscopy (DPCS) to pressures approaching 5 GPa in a diamond anvil cell, representing the highest-pressure implementation of this technique and enabling direct measurement of the structural α-relaxation in a pure liquid at extreme compression. This capability provides access to dynamical regimes previously unexplored by photon correlation spectroscopy and establishes a platform for probing glassy dynamics at high pressure. To describe these measurements, a constrained relaxation-time surface framework is …
Synthesis And Evaluation Of Long-Term History-Aware Medical Dialogue, Hebin Hu, Renke Dai, Ah-Hwee Tan, Yilin Kang
Synthesis And Evaluation Of Long-Term History-Aware Medical Dialogue, Hebin Hu, Renke Dai, Ah-Hwee Tan, Yilin Kang
Research Collection School Of Computing and Information Systems
An effective healthcare agent must be able to recall and reason over a patient’s longitudinal medical history. However, the absence of datasets with realistic long-term dialogue timelines limits systematic evaluation. Real clinical text is constrained by privacy and ethics, while existing benchmarks focus on isolated interactions, failing to capture cross-session reasoning. We introduce a framework for synthesizing high-quality, long-term medical dialogues with LLMs. Our approach entails a knowledge-guided decomposition into three stages: constructing synthetic patient profiles with diverse disease and complication trajectories, generating multiturn dialogues per encounter, and integrating them into a coherent longitudinal history dataset, MediLongChat. We establish three …
Collaborative Practices And Tool Utilization In Software Development Projects: A Student Perspective, Yi Meng Lau, Muhammad Syahmi Bin Abbas, Lingxiao Jiang
Collaborative Practices And Tool Utilization In Software Development Projects: A Student Perspective, Yi Meng Lau, Muhammad Syahmi Bin Abbas, Lingxiao Jiang
Research Collection School Of Computing and Information Systems
Software development is a collaborative activity that depends on effective teamwork, shared understanding, and coordinated use of development practices and tools. While these aspects are well studied in professional environments, they are less frequently examined within software engineering education. This study investigates how students collaborate in group projects, focusing on collaborative practices, tool usage, and their perceptions of software quality. We conducted a quantitative post-project survey with 143 second-year undergraduate students enrolled in a software development course. The results show that students actively share information and often establish team norms to support coordination and collaboration. However, students face challenges in …
Molecular Mechanisms Of Pfas Induced Protein Dysfunction: Implications For Neurodegenerative Risk, Daisy Lee Wilson
Molecular Mechanisms Of Pfas Induced Protein Dysfunction: Implications For Neurodegenerative Risk, Daisy Lee Wilson
Open Access Theses & Dissertations
Per- and polyfluoroalkyl substances (PFAS) are persistent environmental contaminants with widespread human exposure and well-established links to adverse health outcomes. However, despite increasing epidemiological and experimental evidence, the molecular mechanisms underlying PFAS-induced neurotoxicity remain incompletely defined. This dissertation investigates PFAS toxicity across biological scales, integrating protein biophysics with neuronal cell models to elucidate pathways relevant to neurodegeneration. At the molecular level, we demonstrate that PFAS disrupts the structure and function of globular proteins, including the impairment of α-lactalbumin's calcium-binding capacity and of β-lactoglobulin's retinol binding, through concentration-dependent conformational destabilization. By applying these findings to a neuronal model, we show that …