Digital Commons Network^™

Investigation Of Domain Formation During Phase Separation In A Mixture Of Flexible And Rigid Biopolymers, Steven Huntley

All Theses

Complex fluids and heterogenous mixtures composed of multiple types of polymers are found throughout industrial and biological fluid systems. For example, extrusion based additive manufacturing systems pass dense mixtures of polymers through the extrusion heads to deposit composite polymeric materials. In cells, active and complex mixtures of biopolymers self-organize into assemblies that perform critical physiological functions.

Polymers in dense solutions undergo phase separation as a result of differences in physiochemical properties. A few examples of these properties include charge, structure, rigidity, and hydrophobicity. We observe the formation of polymer domains composed of rigid and a flexible biopolymer species that phase …

Using Ion Mobility Mass Spectrometry In Conjuction With Derivatization Methods To Enhance The Separation Of Different Steroid Isomers, Shadrack Lucas

All Theses

One of the major problems facing analytical chemistry challenge is the isomers separation, due to their closely related molecular structures and physicochemical properties. Therefore, in this thesis, we have performed the separation of steroid isomers through the use of ion mobility mass spectrometry, using various chemical approaches. Ion mobility is an effective high-resolution separation techniques that utilizes the mobility of ions in the gas-phase environment. A useful tool for isomeric analysis due to the ability to separate different isomeric classes of steroids according to their varied collision cross-sections, which is achieved by taking advantage of differences in ion mobility.

Moreover, …

Biotinylated Protein Capture And Tween-20 Assisted Exosome Isolations Via Capillary Chanelled Polymer Fiber, Md Khalid Bin Islam

All Theses

In the past two decades, Marcus and colleagues have led the advancement of capillary-channeled polymer (C-CP) fiber stationary phases for biomacromolecule separations, including proteins and nanovesicles. These stationary phases offer notable advantages, including low cost ($5/column), straightforward column fabrication, and the capacity for on-column surface modification, enabling high chemical selectivity. This study examines a C-CP fiber modification strategy for capturing target proteins and develops a Tween-20-assisted C-CP-based hydrophobic interaction chromatography (HIC) method for the isolation and quantification of exosomes from human urine.

The quest for higher-throughput and cost-effective protein isolation techniques remains a key focus in a variety of end …

Local Existence Of Solutions To A Nonlinear Autonomous Pde Model For Population Dynamics With Nonlocal Transport And Competition, Michael R. Lindstrom

School of Mathematical & Statistical Sciences Faculty Publications

Highlights

• Partial differential equation models are ubiquitous in applied sciences.

• A partial differential equation based in ecology is studied for solution existence.

• Energy methods and convergence analysis lead to local classical solutions.

Abstract

In this paper, we prove that a particular nondegenerate, nonlinear, autonomous parabolic partial differential equation with nonlocal mass transfer admits the local existence of classical solutions. The equation was developed to qualitatively describe temporal changes in population densities over space through accounting for location desirability and fast, long-range travel. Beginning with sufficiently regular initial conditions, through smoothing the PDE and employing energy arguments, we obtain a sequence …

A Comparative Analysis Of Field Electron Emission From Carbon Black Embedded Within Insulated Copper Hollowed Wires And Glass Tubes, Hatem A. Al-Braikat, Ahmad M D Jaber, Adel M. Abuamr, Mazen A. Madanat, Aseel A. Al-Jbarart, M-Ali H. Al-Akhras, Marwan S. Mousa

Karbala International Journal of Modern Science

In this study, two different methods are used to investigate carbon black as a cold field electron emitter. The first method is to incorporate carbon black into a specially designed insulated copper hollowed wire. The wire has a cup-shaped structure created by electrochemical etching. The second method involves the incorporation of carbon black into narrow glass tubes. A Comparative analyses is carried out to evaluate the effectiveness of each method. To evaluate the performance of the samples, the current-voltage characteristics will be examined using field electron microscopes. This analysis will provide an understanding of the emission of the carbon black …

Philosophy In Science: Can Philosophers Of Science Permeate Through Science And Produce Scientific Knowledge?, Thomas Pradeu, Maël Lemoine, Mahdi Khelfaoui, Yves Gingras

Presidential Fellows Articles and Research

Most philosophers of science do philosophy ‘on’ science. By contrast, others do philosophy ‘in’ science (PinS), that is, they use philosophical tools to address scientific problems and to provide scientifically useful proposals. Here, we consider the evidence in favour of a trend of this nature. We proceed in two stages. First, we identify relevant authors and articles empirically with bibliometric tools, given that PinS would be likely to infiltrate science and thus to be published in scientific journals (‘intervention’), cited in scientific journals (‘visibility’), and sometimes recognized as a scientific result by scientists (‘contribution’). We show that many central figures …

An Optimization Tool For A Standalone Photovoltaic System, Johanes Kasilima

Tanzania Journal of Engineering and Technology (TJET)

Stand-alone photovoltaic systems (SAPV) are often used in remote areas where access to grid electricity is limited. This system depends on solar energy. However, Photovoltaic (PV) systems need a greater initial investment than conventional sources of energy, and their effectiveness is reliant on a number of environmental conditions such as the unpredictable solar radiation. One step in reducing the investment cost of a PV system is determining the optimal size of solar PV components that minimize costs. This paper presents a Particle Swarm based optimization tool for sizing Stand-alone PV systems. The optimization tool selects the optimal Levelized Cost of …

Reply To: On The Statistical Foundation Of A Recent Single Molecule Fret Benchmark, Dorothy A. Erie, Lydia Kisley, Dushani Dunukara

Faculty Scholarship

In their ‘Matters Arising’ manuscript, Saurabh et al. discuss two issues related to single-molecule Förster resonance energy transfer (smFRET) experiments: the use of the Gaussian noise approximation and spectral crosstalk. Their arguments are based on simulations obtained with parameters that differ significantly from the typical conditions measured experimentally, and, thus, from the regime included in the original study (Götz et al.1). In addition, they make claims about our multi-lab blind study that we would like to rectify. In Table 1, we provide a list of specific statements made by Saurabh et al. with our respective explanations.

Learning To Teach About Climate Justice And Social Justice In Science Methods, Mindy J. Chappell

Northwest Journal of Teacher Education

In November, the Editors of NWJTE sat down for a conversation with Dr. Mindy J. Chappell, a Science Teacher Educator in the College of Education at Portland State University. Dr. Chappell’s passions include developing teachers who are prepared to disrupt normative science ideologies and provide young people with science instruction that encourages and empowers them to be leaders in their communities. She engages in arts-based educational science research through the methodology of Ethnodance (a term she coined). She places young people and their lived experiences at the heart of her work.

Assessment Of Risk Factors Related To Body Pain Complaints In Tanzania Construction Industry, Fatma K. Mohamed

Tanzania Journal of Engineering and Technology (TJET)

The construction industry is associated with risks that can result in musculoskeletal diseases. Although young male workers who are presumed to be healthy dominate the industry in Tanzania, body pain complaints have been widely reported. The aim of this study is to assess the prevalence and causes of body pains in workers. A cross-sectional study involving 396 workers was conducted. A chi square test was used for testing association of independent categorical variables and binary logistic regression analysis was used to determine predictors for body pain complaints. The results show that all study participants complained of at least one form …

Extraction Of Natural Dyes From Delonix Regia Flowers For Cotton Fibres, Lutamyo Nambela, Liberato V Haule

Tanzania Journal of Science

Textile colouration is among the major industry that pollutes the environment with effluents rich in dye chemicals. Most of the dyes used are synthetics which possess health and environmental impacts. Potentially, the use of bio-based dyes and other chemicals can lessen the environmental challenges of the textile effluents. This study reports on sustainable extraction and dyeing of cotton fabric using extract of Delonix regia flowers. The extraction process was done using acidified water as a solvent and the dyeing process was free from hazardous auxiliary chemicals. To improve the dyeing performance, banana sap was used as an affordable and eco-friendly …

The Effects Of Algal Blooms On Oxygen Levels In Lakes Babati And Eyasi, Tanzania, Amelia S. Buriyo, Nyatwere D. Mganga, Mary Melchiory

Tanzania Journal of Science

Globally aquatic ecosystems are reportedly overwhelmed by algal blooms due to excessive deposition of nutrients which ultimately cause hypoxia, leading to massive fish death. This study aimed at assessing the relationship between algae contents and dissolved oxygen (DO) in Lake Babati which is threatened by anthropogenic activities, whereas Lake Eyasi was used as a control. Algae contents (chlorophyll a), DO and surface water temperature were measured using standard methods. Results revealed that the mean algae content was significantly higher (4.47±0.88 mg/L) in Lake Babati than in Lake Eyasi (1.6±0.45 mg/L) (P < 0.05) and was beyond the standard permissible levels for domestic water supply and healthy ecosystem. Conversely, DO was significantly lower in Lake Babati than in Lake Eyasi (P < 0.05). There was no significant difference in water temperature in the two lakes (P > 0.05). Furthermore, there was an inverse relationship between algae …

Green And Blue Water Footprints Of Major Crops In The Wami/Ruvu Basin, Tanzania: Implications For Water Scarcity And Sustainability, Benson Hm Lazaro, Martine M. Hagai, Rubhera Ram Mato

Tanzania Journal of Science

Accurate estimation of the blue and green water requirements of the various crops cultivated in a water basin is essential for planning specific plant/crop irrigation schedules. In this study, the crop water requirements of the major crops grown in the Wami/Ruvu basin were determined using the FAO-CROPWAT model based on meteorological parameters: monthly maximum and minimum temperature, wind speed, mean relative humidity, sunshine hours, rainfall data, and effective rainfall for 23 hydro-meteorological stations distributed in the study area. The studied crops are rice, maize, beans, tomatoes, and sugarcane. The crop reference evapotranspiration (ETo) and actual evapotranspiration (ETc) for each crop …

Inference For Time Series In Change Points And Statistical Learning, Jiaqi Li

Arts & Sciences Graduate Student Theses and Dissertations

This study aims to develop a comprehensive framework for inference theory in time series, with a focus on change-point detection and online learning. First, we introduce an $\ell^2$-based inference approach for multiple change-point detection in high-dimensional time series, which targets dense or spatially clustered signals by a novel Two-Way MOSUM (moving sum) test statistic. We derive the limiting distribution of this $\ell^2$-aggregated statistic by extending the high-dimensional Gaussian approximation to non-stationary spatial-temporal processes. Simulation exhibits promising performance of our test in detecting non-sparse weak signals, and the application to COVID-19 analysis shows the real-world relevance of our method. Next, we …

Electrocatalytic Cyclopropanation Of Active Methylene Compounds, Liang-Hua Jie, Hai-Chao Xu

Journal of Electrochemistry

The development of novel strategies to access cyclopropanes has become increasingly important due to the vital role of these three-membered ring structures in synthetic intermediates, natural products, and pharmaceuticals. Herein, we present an electrocatalytic method for the synthesis of cyclopropanes through intermolecular dehydrogenative annulation of active methylene compounds and arylalkenes. This electrochemical process requires no chemical oxidants, allowing for a speedy access to various functionalized cyclopropanes from inexpensive and readily available materials.

Electrochemical Syntheses Of Aryl-Substituted Benzothiophenes And Phenanthrenes Using Benzenediazonium Salts As The Aryl Radical Precursors, Li-Yuan Lan, Yang-Ye Jiang, Raymond Daniel Little, Cheng-Chu Zeng

Journal of Electrochemistry

Aryl-substituted benzothiophene and phenanthrene are important structural units in medicinal chemistry and materials science. Although extensive effort has been devoted to prepare these compounds and a variety of approaches have been developed to construct the 2-substituted benzothiophene core structure, environmental-friendly and efficient synthetic means are still desired. Based on our previous electrochemical Minisci-type arylation reaction with aryl diazonium salt as the aryl precursor, as well as the work from König’s group, herein, we described the use of paired electrolysis to achieve 2-aryl benzothiophenes and 9-aryl phenanthrenes employing benzenediazonium salts as the aryl radical precursors. Initially, 2-methylthiobenzendiazonium salt 1a and 4-methylbenzene …

Synthesis And Characterization Of Silver(I) And Manganese(Ii) Complexes With Thione Imidazoles, Shannon Keyser, Audrey Lawrence, Jaime M. Murphy Ph.D.

Honors Theses

Coordination polymers are chemical complexes with versatile applications such as catalysts, electrical conduc-tors, non-linear optics, magnetics, chemical sensing, and molecular storage. The polymers are comprised of a repeating series of metal-ligand complexes, which form various structures in varying ratios depending on the metal and ligand used. Certain metal-ligand combinations have shown particular promise as potentially being polymers or, if not polymers, possessing other useful features such as electromagnetic conductivity. Complexes were synthesized using silver(I) and manganese(II) with the ligands methimazole, 2-mercaptoimidazole, and thiocarbanilide with counterions of either chloride or nitrate. These com-plexes were characterized using elemental analysis, infrared spectroscopy, and …

The Purification And Thermal Stability Of The Peroxidase Enzyme In Cucurbita Moschata, Garen Hamner

Senior Honors Theses

Peroxidases are enzymes that catalyze the reduction of hydrogen peroxide to water while oxidizing organic substrates and are valuable in spheres like industrial and medical applications and histochemistry. Limitations still exist in the use of the well-studied horseradish peroxidase for certain activities due to limitations like poor thermal stability, thus the search for novel peroxidases that can overcome these limitations is an active area of research. Butternut squash peroxidase (Cucurbita moschata) (BSP) shows promise due to significant activity being found in the skin and apparent enhanced thermal stability, but an efficient purification scheme for it is lacking, as well as …

Priming Through Persuasion: Towards Secure Password Behavior, Rizu Paudel, Mahdi Nasrullah Al-Ameen

Computer Science Student Research

Users tend to create weak passwords even for the important accounts. The prior research shed light on user’s insecure password behavior, and why the interventions, including requirement specification (e.g., password composition policies) and feedback systems (e.g., password meters) fail in practice. To this end, we propose and evaluate the concept: priming-through-persuasion in the realm of secure password creation. In particular, we created visual designs, aimed at priming users about the repercussions of weak passwords before their password creation. We base our designs on two forms of persuasion methods: pathos and logos. Pathos appeals to people’s emotion in order to persuade …

Structural Homology Of Mite Profilins To Plant Profilins Is Not Indicative Of Allergic Cross-Reactivity, Andrea O'Malley, Sahana Sankaran, Avery Carriuolo, Kriti Khatri, Krzysztof Kowal, Maksymilian Chruszcz Ph.D.

Faculty Publications

Structural and allergenic characterization of mite profilins has not been previously pursued to a similar extent as plant profilins. Here, we describe structures of profilins originating from Tyrophagus putrescentiae (registered allergen Tyr p 36.0101) and Dermatophagoides pteronyssinus (here termed Der p profilin), which are the first structures of profilins from Arachnida. Additionally, the thermal stabilities of mite and plant profilins are compared, suggesting that the high number of cysteine residues in mite profilins may play a role in their increased stability. We also examine the cross-reactivity of plant and mite profilins as well as investigate the relevance of these profilins …

Spectral Properties Of Wetlands In Michigan Using Remote Sensing To Identify And Classify Wetlands In Roscommon County, Michigan, Kolin Williamson

USF Tampa Graduate Theses and Dissertations

Biological, geological, and physical. These are only a handful of the many environmental aspects that wetlands functions maintain and protect. Unfortunately, wetlands within the United States have been razed at an alarming rate. The State of Michigan has not gone through this unscathed either, loosing over 1000 acres of wetland a year. One of the most important tools to prevent this destruction are the maps and programs that show where these essential ecosystems are located. The current, federally-created maps and imaging software in use by environmental consultants and contractors may not be up to date which can pose challenges for …

“It’S Hard For Him To Make Choices Sometimes And He Needs Guidance”: Re-Orienting Parental Control For Children, Prakriti Dumaru, Hanieh Atashpanjeh, Mahdi Nasrullah Al-Ameen

Computer Science Student Research

With access to devices and online platforms at an increasingly younger age, it is essential to protect children from potential online risks. In our studies, we particularly focused the parents who have a child under 13 years of age. To this end, deriving from developmental psychology, we base our low-fidelity prototype design (termed as ‘treatment’) on a set of design principles focusing on open communication, instilling self-regulation, and availing granularity along with designs of existing Google’s parental control as a baseline. First, we conducted semi-structured interviews with 21 parents to understand their perceptions, including suggestions for design improvement within our …

Linking Reactive Nitrogen Species Within The Vadose Zone With Surface Irrigation, Kaitlyn Richards

Honors Program: Senior Projects (Public)

This study investigated the relationship between irrigation methods and the mobilization of nitrogen in the vadose zone, focusing on soil properties, water dynamics, and nitrogen species distribution. Data collected from dryland and pivot-irrigated soil cores reveal distinct patterns in water content, bulk density, soil texture, pH, conductivity, and nitrogen concentrations. Results indicated that water content has a major influence in nitrogen availability and microbial activity. Nitrate-N and ammonium-N concentrations varied between dryland and pivot soils, with notable disparities observed. In dryland soils, nitrate-N concentrations varied widely across depth intervals, with notable accumulation in deeper layers, while ammonium-N concentrations exhibited a …

Numerical Investigation To Produce A Fundamental Polygon, Elizabeth Sipes

Honors College Theses

There exist multiple types of geometry, differing in the postulates they are based on, and therefore the theorems and proofs that make up said geometry. Hyperbolic geometry differs from others by allowing there to exist multiple lines through a single point not on a given line, that are parallel to the given line. Every geometry has the idea of distance and isometries, distance preserving maps. By considering special collections of isometries called discrete groups, we can construct interesting surfaces, such as the torus and genus-g surface. The connection between the surface and the discrete group can be understood through …

Final 2024 Residential Metals Abatement Program (Rmap) Baptist Student Union (Former Mckinley School) Soil Remedial Action Work Plan (Rawp), Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Net Fluxes Of Broadband Shortwave And Photosynthetically Active Radiation Complement Ndvi And Near Infrared Reflectance Of Vegetation To Explain Gross Photosynthesis Variability Across Ecosystems And Climate, Kanishka Mallick, Joseph Verfaillie, Tianxin Wang, Ariane Arias Ortiz, Daphne Szutu, Koong Yi, Yanghui Kang, Robert Shortt, Tian Hu, Mauro Sulis, Zoltan Szantoi, Gilles Boulet, Joshua B. Fisher, Dennis Baldocchi

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

A significant challenge in global change research is understanding how vegetation interacts with the environment to influence ecosystem gross primary productivity (GPP) through carbon assimilation. One emerging objective is to consistently predict GPP fluctuations worldwide by establishing a robust scaling relationship between GPP measured at flux towers and satellite spectral reflectance data. However, a major hurdle in achieving this goal is the discrepancy in spatial resolution between early satellite measurements and eddy flux measurements. By using a large set of growing season data covering 100 site-years in North and Central America, we explored the potential of transforming incident and reflected …

Seagrass Conservation And Restoration To Mitigate Ocean Acidification And Climate Change, Tori Benson, Emi Wagner, Jaeger Reed

Celebrating Scholarship and Creativity Day (2018-)

For millennia, various seagrass species have been sequestering and anchoring aquatic carbon into oceanic sediment. The crucial role of seagrasses involves helping mitigate climate change, which emphasizes the urgent need to conserve, sustain, and manage them as part of global climate action efforts. Restoration and conservation studies have shown significant reversal of potential damaging effects, however human activity continues to set back efforts faster than they can proceed. Multiple studies have concluded that there has been a decline in seagrass meadows in previously dense areas; and due to this, surrounding pH levels have declined and rising atmospheric carbon poses a …

Modeling And Synthesis Of 3-(2,6-Disubstituted 5-Pyrimidyl) Propionic Acids As Inhibitors Of Low Molecular Weight Protein Tyrosine Phosphatase (Lmw-Ptp), Kennedy Bueno, Madisen Carter

Celebrating Scholarship and Creativity Day (2018-)

Low molecular weight protein tyrosine phosphatase (LMW-PTP) is an enzyme and a known signal pathway for growth factors and cellular transformation in eukaryotic cells. Our research aims to synthesize 12 new potential inhibitors of LMW-PTP and analyze their inhibitory activity and binding affinity. The inhibition of both isoforms of LMW-PTP has been the primary focus of research due to their potential role in breast, colon, and other cancers as well as type II diabetes. One known inhibitor, pyridoxal 5’- phosphate (PLP), is essential for various enzymatic reactions within the body, such as the synthesis of neurotransmitters, and is therefore impractical …

Improving The Water Solubility Of Cannabidiol Using A Peptide Carrier, Melek Parlak Khalily

Turkish Journal of Chemistry

Cannabidiol (CBD), nonpsychotropic cannabinoid found in Cannabis sativa, is a very promising drug candidate offering many differential effects such as sedative, antiinflammatory, antioxidant, and neuroprotective properties. Nevertheless, the therapeutic use of CBD is hindered by its lack of water solubility and relatively low bioavailability. Various carriers have been used to address the solubility issues of CBD and other highly lipophilic drugs so far. However, self-assembled peptide nanostructures as carrier have not been used to improve the water solubility of CBD yet. In this study, a self-assembling peptide micelle was demonstrated to be an effective vehicle for encapsulation of CBD and …

Computational Drug Repurposing Effort For Identifying Novel Hits For The Treatment Of Diseases Such As Endometriosis, Uterine Fibroids, And Prostate Cancer, Ahmet Buğra Ortaakarsu, Hi̇lal Medetali̇beyoğlu

Turkish Journal of Chemistry

This research aimed to identify potential drug compounds from the ZINC15 molecule database that could effectively treat GnRH1R-related diseases. The study utilized molecular docking and molecular dynamics methods to achieve this goal, which is crucial in drug repurposing research. The virtual screening process involved analyzing known drug compounds using molecular docking. Additionally, molecular dynamics simulations and MM-GBSA were employed to evaluate the stability of the complexes and determine the interactions between the compounds and protein structure. As a result, this study provides significant insights for treating diseases such as endometriosis, uterine fibroids, and prostate cancer related to GnRH1R. The study …