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Carbon Dioxide Dynamics In The Carbonate Critical Zone, Savoy Experimental Watershed, Arkansas, Usa, Michael Darvin Jones Dec 2024

Carbon Dioxide Dynamics In The Carbonate Critical Zone, Savoy Experimental Watershed, Arkansas, Usa, Michael Darvin Jones

Graduate Theses and Dissertations

The dynamics of carbon dioxide (CO2) within the Earth’s critical zone (CZ) are essential for driving spatial and temporal variations of carbonate dissolution and precipitation, which are fundamental to subsurface porosity and permeability development. However, there is still a significant knowledge gap regarding the patterns of CO2 transport and production within the carbonate critical zone (CCZ). In this study, we investigated these dynamics within a mantled karst terrain at the Savoy Experimental Watershed (SEW) in Northwest Arkansas.

Previous monitoring of partial pressure of CO2 (PCO2) and dissolution rates at karst springs in …


Recreational Fishing For Western Rock Lobster: Estimates Of Participation, Effort And Catch In 2023/24, Claire B. Smallwood, Karina L. Ryan, Alissa C. Tate Dec 2024

Recreational Fishing For Western Rock Lobster: Estimates Of Participation, Effort And Catch In 2023/24, Claire B. Smallwood, Karina L. Ryan, Alissa C. Tate

Fisheries Research Reports

The Western Rock Lobster (WRL) (Panulirus cygnus) is the most commonly caught Rock Lobster (RL) species in Western Australia. Catches from the commercial and recreational sectors are required to determine and monitor Total Allowable Commercial Catch (TACC), Total Allowable Recreational Catch (TARC) and the proportion of Allowable Harvest Level (AHL) achieved. The TARC is set at 5% of the AHL and evaluated in the harvest strategy based on a 5-year average.

Data for the recreational sector are obtained using phone-recall surveys to provide annual estimates of participation, fishing effort and retained catch (by numbers) from recreational fishers who hold a …


Analysis Of Impulsive Differential Equation Models Of Cell Populations Undergoing Radiation Therapy, Abigail D'Ovidio Long Dec 2024

Analysis Of Impulsive Differential Equation Models Of Cell Populations Undergoing Radiation Therapy, Abigail D'Ovidio Long

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Radiation therapy is a mode of treatment which is implemented for approximately 50% of cancer patients. Treatment needs to be able to kill cancer cells, but also do minimal damage to surrounding healthy tissue. We propose two main impulsive differential equation models of radiation therapy to capture the periodic nature of the treatment. These models build off of previous studies using clinical data to ensure biological relevance. The first model incorporates only cancer cell populations, and we provide parameter relationships which theoretically ensure treatment outcomes of cancer eradication, cancer approaching a carrying capacity, and cancer approaching a periodic solution. We …


Local Rural Knowledge And Early Childhood Informal Science Education In Rural Nebraska, Sarah Michelle Paulos Dec 2024

Local Rural Knowledge And Early Childhood Informal Science Education In Rural Nebraska, Sarah Michelle Paulos

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

This study aims to discover the existing experiences that lead to local rural knowledge (LRK) of specific rural Northeast Nebraska communities. This information will assist in understanding the impact that LRK has on young children’s science knowledge in rural communities. By engaging in hands-on experiences and interactions, science learning goals for children may be achieved and developed through science outreach programs. During Phase 1 of this study, adults in the selected rural communities participated in an online survey indicating their knowledge of various common rural phrases with the option to share personal stories of experiences and family history. This information …


Variable Selection In Distance Metric Learning And Triplet Constraints For Deep Learning Based Ordinal Classification, James D. Clothier Dec 2024

Variable Selection In Distance Metric Learning And Triplet Constraints For Deep Learning Based Ordinal Classification, James D. Clothier

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

The purpose of this research is to augment linear and kernelized ordinal distance metric learning (L/KODML) techniques with a proposed variable selection methodology that integrates the Sequential Multi-Response Feature Selection (SMuRFS) algorithm. Additionally, we aim to embed ordinal triplet constraints into a deep learning architecture, and to propose a general framework for deep learning-based ordinal classification. A variety of simulation studies and real data experiments were conducted to evaluate the various methodologies. For the distance metric learning and variable selection, results showed that the integration of SMuRFS performed effective variable selection and improved prediction accuracy. For the triplet constraints, incorporating …


Performance Of Acoustic Telemetry And Space Use Of Pallid Sturgeon In The Lower Platte River, Nebraska, Christopher F. Pullano Dec 2024

Performance Of Acoustic Telemetry And Space Use Of Pallid Sturgeon In The Lower Platte River, Nebraska, Christopher F. Pullano

School of Natural Resources: Dissertations, Theses, and Student Research

Pallid Sturgeon (Scaphirhynchus albus) are centenarian, potamodromous, rheophiles that historically occupied the Missouri River and Mississippi River basins. Listed on the U.S. Endangered Species Act in 1990, population declines are attributed to habitat fragmentation and degradation, as well as overharvest, and hybridization. A knowledge gap exists regarding the extent to which tributaries facilitate key life stages for Pallid Sturgeon. This study evaluated the capacity of acoustic telemetry to monitor the movements of Pallid Sturgeon in a shallow, braided tributary to the Missouri River. The specific objectives were to (1) evaluate the environmental variables influencing the performance of acoustic …


Occupancy Of Fish Species Of Greatest Conservation Need And Temporal Patterns Of Assemblage Occurrence In Sandhills Ecoregion, Nebraska Streams, Braxton M. Newkirk Dec 2024

Occupancy Of Fish Species Of Greatest Conservation Need And Temporal Patterns Of Assemblage Occurrence In Sandhills Ecoregion, Nebraska Streams, Braxton M. Newkirk

School of Natural Resources: Dissertations, Theses, and Student Research

Fish species’ occurrence is influenced by environmental conditions across multiple spatial and temporal scales. Alteration to stream systems has the potential to affect occurrence patterns of fish species. Stream systems of the North American Great Plains face threats originating from climate change and anthropogenic activities resulting in negative implications for many fish species. The Sandhills Ecoregion, Nebraska is considered one of the largest intact grasslands in North America, and thus may experience fewer threats than surrounding areas. Stream systems of the Sandhills Ecoregion are home to 12 fish species of greatest conservation need (SGCN). Little context exists regarding the environmental …


Spatial Ecology Of American Bison On Vermejo Park Ranch, New Mexico, Kate Ann Asmus Dec 2024

Spatial Ecology Of American Bison On Vermejo Park Ranch, New Mexico, Kate Ann Asmus

School of Natural Resources: Dissertations, Theses, and Student Research

American bison (Bison bison) are a keystone species that impact grassland productivity, plant diversity, and landscape heterogeneity. We used GPS telemetry and a replicate herbivore grazing experiment on Vermejo Park Ranch in northeastern New Mexico to advance understanding of bison spatial ecology and grazing dynamics. First, we evaluated the potentially disparate influences of forage productivity and site fidelity on the size and selection of home ranges of bison. Home range size was strongly negatively influenced by forage productivity. However, home range selection was influenced more strongly by site fidelity than spatial variation in forage, as bison selected home …


A Review Of The Philosophy Of Flood Risk Communication And Education: New Insights Informed By Critical Complexity, Timothy Lutz Dec 2024

A Review Of The Philosophy Of Flood Risk Communication And Education: New Insights Informed By Critical Complexity, Timothy Lutz

Earth & Space Sciences Faculty Publications

The approach to flooding in the U.S. is strongly influenced by research and practices that place the responsibility for managing risk on scientific and technical experts. But there is a recognition that the public generally needs to be more engaged and responsible. There is currently a disconnect between the objective knowledge of experts and the more subjective ways in which people experience floods and flood risk. To bridge this gap, I start with a review of the philosophy that informs government policies and the societal worldview. While societal leaders have maintained a mechanistic vision of a world that is ultimately …


Time Series Decomposition Of Land Surface Temperature For Long-Term Trend Forecasting And Impact On Nesting Sea Turtle Habitats In The Arabian Gulf, Sachi Perera, Rommel H. Maneja, Mohamed Allali, Cyril Rakovski, Erik Linstead, Daniele Struppa, Ali Qasem, Hesham El-Askary Dec 2024

Time Series Decomposition Of Land Surface Temperature For Long-Term Trend Forecasting And Impact On Nesting Sea Turtle Habitats In The Arabian Gulf, Sachi Perera, Rommel H. Maneja, Mohamed Allali, Cyril Rakovski, Erik Linstead, Daniele Struppa, Ali Qasem, Hesham El-Askary

Mathematics, Physics, and Computer Science Faculty Articles and Research

Improving land surface temperature (LST) modeling is vital for mitigating climate change effects on various ecosystems and marine habitats such as important sea turtle habitats. Over the past decade, extreme temperatures have likely significantly affected nesting sea turtle habitats in the Arabian Gulf, with predominantly female hatchlings creating an imbalance in the sex ratio. Such shifts have profound implications for these habitats’ long-term survival and conservation management. This study leverages statistical machine learning models to measure ongoing temporal variations in LST. We break down the LST time series into trend, seasonal, and noise components using classical decomposition methods like X11, …


Investigation Of Magnesium-Potassium Phosphates As Potential Nuclear Waste Form For The Immobilization Of Minor Actinides, Hans Conrad Zur Loye, Petr Vecernik, Monika Kiselova, Vlastislav Kašpar, Hana Korenkova, Vlastimil Miller, Petr Bezdicka, Jan Šubrt, Natalija Murafa, Volodymyr Shkuropatenko, Sergey Sayenko Dec 2024

Investigation Of Magnesium-Potassium Phosphates As Potential Nuclear Waste Form For The Immobilization Of Minor Actinides, Hans Conrad Zur Loye, Petr Vecernik, Monika Kiselova, Vlastislav Kašpar, Hana Korenkova, Vlastimil Miller, Petr Bezdicka, Jan Šubrt, Natalija Murafa, Volodymyr Shkuropatenko, Sergey Sayenko

Faculty Publications

Several recent studies have evaluated technologies of spent nuclear fuel processing specifically for solidifying transuranic (TRU) waste as a by-product of fission. Of the TRU group, plutonium and the minor actinides will be responsible for the bulk of the radiotoxicity and heat generation of spent nuclear fuel in the long term (300 to 20,000 years). In this study, we investigated magnesium potassium phosphate (MKP)-based compounds as host waste forms for the encapsulation of inactive trivalent Nd and Sm as analogues of the minor trivalent actinides, Am and Cm. Waste forms were fabricated under ambient atmospheric conditions by adding 5 wt.% …


Deep Learning Approach For Dental Anomalies X-Ray Imaging Using Yolov8, Amelia Ritahani Ismail, Md Salim Sadman Taseen Dec 2024

Deep Learning Approach For Dental Anomalies X-Ray Imaging Using Yolov8, Amelia Ritahani Ismail, Md Salim Sadman Taseen

Knowledge Engineering and Data Science

Dental X-ray imaging is a critical diagnostic tool for identifying various dental anomalies. However, manual interpretation is time-consuming, prone to human error, and requires specialized expertise. Deep learning models, particularly object detection frameworks like YOLO, have demonstrated promising results in automating medical image analysis. This study aims to develop and evaluate a YOLOv8-based deep learning model for automated detection and classification of 14 dental anomaly categories, including Caries, Crowns, Fillings, Implants, and Periapical lesions. The proposed approach addresses limitations in previous YOLO versions by leveraging anchor-free detection and enhanced feature extraction for improved accuracy. The model was trained on a …


Uptake Of Contaminants Of Emerging Concerns (Cecs) By Plants Irrigated With Recycled Waters, Abid Hussain Dec 2024

Uptake Of Contaminants Of Emerging Concerns (Cecs) By Plants Irrigated With Recycled Waters, Abid Hussain

UNLV Theses, Dissertations, Professional Papers, and Capstones

The increasing demand for water in arid and semi-arid regions necessitates the use of recycled water (RW) for irrigation. RW is a viable alternative to conventional irrigation water at most locations, but it can be a major route for contaminants of emerging concerns (CECs) to be taken up by the tissues of food crops, thereby leading to their subsequent entry into the food chain. CECs include pharmaceuticals, personal care products, and industrial chemicals that are generally present at low concentrations in environmental waters, hence their common designation as trace organic compounds (TOrCs), and CECs also include microbiological constituents such as …


Using Neighborhood Information To Improve Fiber Direction Estimation From Neuroimaging Data, Anjan Mandal Dec 2024

Using Neighborhood Information To Improve Fiber Direction Estimation From Neuroimaging Data, Anjan Mandal

UNLV Theses, Dissertations, Professional Papers, and Capstones

Accurately estimating neuronal fiber directions is crucial in neuroimaging analysis. The Ball-and-Stick Model (BSM), introduced by Behrens et al. (2003), and widely used in software tools like FSL, remains one of the most popular models for this purpose. BSM analyzes each voxel individually, based solely on its signal information.In this dissertation, we propose modifications to BSM, that incorporate signal information from neighboring voxels in the estimation process, potentially improving the accuracy of the estimates. Additionally, within the estimation process, we introduce two novel proposal distributions to enhance the efficiency of the Markov chain Monte Carlo sampling procedure on the simplex …


Mechanically Cost-Effective Approach For Bipedal Walking In Robots Using Instantaneous Collision Angle, Smit R. Patel Dec 2024

Mechanically Cost-Effective Approach For Bipedal Walking In Robots Using Instantaneous Collision Angle, Smit R. Patel

UNLV Theses, Dissertations, Professional Papers, and Capstones

Humans, as bipedal locomotors, are effective at reducing the mechanical cost of transport (CoTmech) by adopting movement strategies and gaits that minimize energy expenditure for a given distance. By using different gaits at different speeds, leveraging their long spring-like tendons and muscle elasticity which store and release energy during movement, humans reduce the mechanical effort required for locomotion. Current locomotion solutions offered in bipedal robots, based on legacy walking and running gait models, are not great at energy efficiency unless walking at very low speeds. Additionally, the control system of robots, designed to ensure stability and adaptability, requires substantial resources, …


Addressing Low Molecular Weight Chemical Peaking Events During Direct Potable Reuse By Granular And Biological Activated Carbon, Ceonie Washington Dec 2024

Addressing Low Molecular Weight Chemical Peaking Events During Direct Potable Reuse By Granular And Biological Activated Carbon, Ceonie Washington

UNLV Theses, Dissertations, Professional Papers, and Capstones

Direct Potable Reuse (DPR) is an innovative solution designed to address water scarcity by treating wastewater to directly produce safe drinking water. As droughts and water shortages become more frequent, DPR offers a sustainable and localized water supply by incorporating advanced treatment processes. DPR systems typically rely on a combination of technologies such as ozone followed by biological activated carbon (O3/BAC), reverse osmosis (RO), and advanced oxidation processes (AOPs) to remove a wide range of contaminants. However, low molecular weight organic compounds (LMWCs), particularly volatile organic compounds, can sometimes pass through RO membranes and AOP systems.

California's DPR regulations currently …


Dual-Channel Side Channel Attack: Improved Aes Key Decryption By Combining Power And Electromagnetic Side Channels With Convolutional Neural Networks, Sean P. O'Neill Dec 2024

Dual-Channel Side Channel Attack: Improved Aes Key Decryption By Combining Power And Electromagnetic Side Channels With Convolutional Neural Networks, Sean P. O'Neill

Theses and Dissertations

This research introduces a novel DL approach for SCA that combines power consumption and EM signals to enhance encryption key deduction by leveraging a dual-channel CNN architecture. A new dataset, consisting of simultaneous power and EM signal collections during 128-bitAES encryption, was developed to train and evaluate the model’s effectiveness. The combined approach achieved an 88% reduction in traces needed, from 50 traces to 6, for encryption key classification, outperforming traditional methods such as random forest, DPA, DEMA,and individual side channel CNN models. These findings highlight the potential of integrating multiple side channels in SCA to improve performance without the …


An Adaptive And Parallel Direct Solver For Elliptic Partial Differential Equations, Damyn Chipman Dec 2024

An Adaptive And Parallel Direct Solver For Elliptic Partial Differential Equations, Damyn Chipman

Boise State University Theses and Dissertations

We introduce the quadtree-adaptive Hierarchical Poincaré-Steklov (QAHPS) method, an adaptive direct method for solving elliptic partial differential equations on a hierarchy of adaptively refined finite volume meshes. The QAHPS method builds up a solution operator set with O(N^3/2) complexity that acts as the factorization of the system matrix, with linear O(N) complexity for the application of the solution operator set to any number of right-hand side vectors. As the solution operator set is built up by merging local subdomains, it can be adapted as the mesh is refined and coarsened. The method is an …


Composites Developed By The Reaction Of Elemental Sulfur With Biologically Derived Fats And Oils, Katelyn Tisdale Dec 2024

Composites Developed By The Reaction Of Elemental Sulfur With Biologically Derived Fats And Oils, Katelyn Tisdale

All Dissertations

Human civilization’s modern infrastructure relies mainly on cement and petrochemical products. However, the production of these building materials have harmful ecological effects such as green gas emissions, therefore intensifying the need to develop alternative, sustainable structural materials from renewably sourced or waste material precursors. The work presented herein investigates various biomass derived resources that serve as the olefin source for reaction with elemental sulfur, another abundant waste source, via inverse vulcanization to form high strength composites competitive with that of traditional building materials.

Chapter one reviews various techniques that have been developed and executed in an effort towards lignin valorization …


Influence Of Glycopolymer Structure On Amphiphilic, Hybrid, Linear Branched Block Copolymer Properties For Use In Biomedical Applications, Kevin Green Dec 2024

Influence Of Glycopolymer Structure On Amphiphilic, Hybrid, Linear Branched Block Copolymer Properties For Use In Biomedical Applications, Kevin Green

Dissertations

The focus of this dissertation is evaluating and adding fundamental knowledge regarding the structure-property relations of glycopolymers used in the design of hybrid block copolymers (HBC) that are cable of self-assembling into delivery vehicles for biomedical applications. A shift to the utilization of natural materials in the design and fabrication of drug-delivery vehicles has garnered significant attention. Understanding the effects of linear glycopolymers content and composition on the resulting HBCs properties can provide valuable insight into how these materials may be tailored for use in targeted biological applications.

The first chapter introduces current literature on the need for improvement in …


Sedimentary Characteristics Of Flood Deposits In Coastal And Fluvial Environments: Examples From Washover Fans (North Carolina, Usa) And Floodplain Deposits (Mississippi, Usa), Shara Gremillion Dec 2024

Sedimentary Characteristics Of Flood Deposits In Coastal And Fluvial Environments: Examples From Washover Fans (North Carolina, Usa) And Floodplain Deposits (Mississippi, Usa), Shara Gremillion

Dissertations

Extreme flooding from severe and prolonged meteorological events and / or overbanking rivers are some of the most deadly and expensive disasters globally, impacting millions of lives, the environment, and property. People living in vulnerable areas, such as near coasts and rivers, are the first to be impacted with effects of these flood hazards. Scientific studies and their results can aid communities and officials in planning and preparing for those flood impacts. In this three-part study, flood impacts from coastal storms in North Carolina, and flooding along the Mississippi River (MSR) in the state of Mississippi, USA are assessed from …


Prevalence Of Autism Spectrum Characteristics In Students Taking Undergraduate Computing Courses, Rachel Michaela Mettenbrink Dec 2024

Prevalence Of Autism Spectrum Characteristics In Students Taking Undergraduate Computing Courses, Rachel Michaela Mettenbrink

School of Computing: Dissertations, Theses, and Student Research

The incidence rate of autism spectrum condition (ASC) has increased significantly in recent decades, as awareness of the condition and its impacts increases amongst clinicians, parents, and the general population. Medical literature has proposed that there may be a relationship between ASC and participation in the computing field. This study tests for the prevalence of autism spectrum condition traits measured by delivering the Autism Spectrum Quotient (AQ) to a population of undergraduate computer science students. We examine the relationships between AQ scores and students taking undergraduate computer science classes, sex, socioeconomic status, and parents in the computing industry. Additionally, we …


(R2098) Dynamic Analysis Of Stochastic Leslie-Gower Biological Predator-Prey Model With Prey Cannibalism, Sada Nand Prasad, Itendra Kumar Universiry Of Delhi, India, Pawan Kumar Dec 2024

(R2098) Dynamic Analysis Of Stochastic Leslie-Gower Biological Predator-Prey Model With Prey Cannibalism, Sada Nand Prasad, Itendra Kumar Universiry Of Delhi, India, Pawan Kumar

Applications and Applied Mathematics: An International Journal (AAM)

In this paper, we study the dynamical analysis of a stochastic Leslie–Gower biological predator– prey model. Earlier, the Leslie–Gower model was studied in the context of biological systems, including cases involving cannibalism. In our model, we investigate the dynamic properties of a stochastic Leslie–Gower predator–prey ecological system using the stability of invariant measures on invariant sets, where the invariant measures are shown to be ergodic. We also conduct a threshold analysis to study the stochastic persistence and extinction of species. Stochastic bifurcation is also examined. The theoretical results are supported by numerical simulations and examples. Intra-species competition is considered and …


Spatial-Textural Study Of Siliciclastics In A Navajo Sandstone Carbonate Lens, Christopher L. Rupe Dec 2024

Spatial-Textural Study Of Siliciclastics In A Navajo Sandstone Carbonate Lens, Christopher L. Rupe

Loma Linda University Electronic Theses, Dissertations & Projects

Flat-lying carbonate deposits in the Lower Jurassic Navajo Sandstone have long been interpreted as interdune lacustrine deposits. This dissertation critically assesses such inference through the study of an exceptionally well-preserved carbonate deposit in the Trough Canyon area, northwest of Moab, Utah. Thickness measurements along multiple cross-sectional exposures were used to construct an isopach map, approximating the original size and lenticular geometry of the deposit. Dip directions were recorded from foreset strata in cross-bed sets stratigraphically overlying the deposit to infer the approximately coeval direction of siliciclastic transport across the carbonate basin. These data sets yielded a contextual framework for studying …


Microplastic Degradation Compared Among Dated Salton Sea Strandlines, Maria Alejandra Roman Medrano Dec 2024

Microplastic Degradation Compared Among Dated Salton Sea Strandlines, Maria Alejandra Roman Medrano

Loma Linda University Electronic Theses, Dissertations & Projects

This thesis investigates the environmental degradation of plastic materials, with a focus on polyethylene terephthalate (PET), through a multi-phase study conducted at the Salton Sea, a closed-basin lake in a semi-arid region of California. The research addresses three core objectives: (1) developing a microplastic (MP) extraction method tailored for clay-rich sediments, (2) characterizing surface degradation of various plastic types, including PET, BoPET, HDPE, LDPE, and EPS, using advanced microscopy and spectroscopy, and (3) examining the long-term weathering of PET through samples collected from dated lake strandlines.

The extraction protocol successfully isolates MPs without oxidation, using ZnCl₂ and extended soaking to …


Front Matter Dec 2024

Front Matter

The Synapse: Intercollegiate science magazine

No abstract provided.


The Magic Of Bioluminescence: How Animals Illuminate The Dark, Eleanor St. Clair Dec 2024

The Magic Of Bioluminescence: How Animals Illuminate The Dark, Eleanor St. Clair

The Synapse: Intercollegiate science magazine

No abstract provided.


To Mine Or Not To Mine?: Discovery Of Polymetallic Nodules And Discussions On Deep-Sea Mining, Haze Doleys Dec 2024

To Mine Or Not To Mine?: Discovery Of Polymetallic Nodules And Discussions On Deep-Sea Mining, Haze Doleys

The Synapse: Intercollegiate science magazine

No abstract provided.


Density Functional Theory And Machine Learning Analysis Of C—C Reductive Coupling From Terminal Cyanido And Cyaphido Complexes, Roberto Magdiel Escobar Dec 2024

Density Functional Theory And Machine Learning Analysis Of C—C Reductive Coupling From Terminal Cyanido And Cyaphido Complexes, Roberto Magdiel Escobar

Theses and Dissertations

Carbon–carbon (C–C) bond activation has gained increased attention as a direct method for the synthesis of pharmaceuticals and industrial chemistry. Due to the thermodynamic stability and kinetic inaccessibility of the C–C bonds, however, activation of C–C bonds by homogeneous transition-metal catalysts under mild homogeneous conditions is still a challenge. Most of the systems in which the activation occurs either have aromatization or relief of ring strain as the primary driving force. The activation of unstrained C–C bonds of phosphaalkynes does not have this advantage. This study employs Density Functional Theory (DFT) calculations using the Gaussian16 package to elucidate and compare …


Assessing Reproducibility Challenges In Clinical Metabolics, Darcy Lin Cochran Dec 2024

Assessing Reproducibility Challenges In Clinical Metabolics, Darcy Lin Cochran

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Current metabolomics research is expanding to be multiplatform and interdisciplinary. Metabolomic analysis has the potential to provide detailed insight into any biological system of interest to analyze the underlying molecular mechanisms of variables like environment, disease, and genetics. Human clinical metabolomics is a major research area that is often focused on finding biomarkers or panels of biomarkers for different diseases. However, results are difficult to compare across different laboratories since the field of metabolomics has yet to widely adopt best practices for sample preparation, data acquisition and data processing, results are difficult to compare across different laboratories.

This thesis focuses …