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Multiparametric Mri Along With Machine Learning Predicts Prognosis And Treatment Response In Pediatric Low-Grade Glioma, Anahita Fathi Kazerooni, Adam Kraya, Komal Rathi, Meen Chul Kim, Arastoo Vossough, Nastaran Khalili, Ariana Familiar, Deep Gandhi, Neda Khalili, Varun Kesherwani, Debanjan Haldar, Hannah Anderson, Run Jin, Aria Mahtabfar, Sina Bagheri, Yiran Guo, Qi Li, Xiaoyan Huang, Yuankun Zhu, Alex Sickler, Matthew R Lueder, Saksham Phul, Mateusz Koptyra, Phillip Storm, Jeffrey Ware, Yuanquan Song, Christos Davatzikos, Jessica Foster, Sabine Mueller, Michael J Fisher, Adam Resnick, Ali Nabavizadeh

Department of Neurosurgery Faculty Papers

Pediatric low-grade gliomas (pLGGs) exhibit heterogeneous prognoses and variable responses to treatment, leading to tumor progression and adverse outcomes in cases where complete resection is unachievable. Early prediction of treatment responsiveness and suitability for immunotherapy has the potential to improve clinical management and outcomes. Here, we present a radiogenomic analysis of pLGGs, integrating MRI and RNA sequencing data. We identify three immunologically distinct clusters, with one group characterized by increased immune activity and poorer prognosis, indicating potential benefit from immunotherapies. We develop a radiomic signature that predicts these immune profiles with over 80% accuracy. Furthermore, our clinicoradiomic model predicts progression-free …

Optimizing Electrode Configurations For Eeg Mild Cognitive Impairment Detection, Yi Jiang, Xin Zhang, Zhiwei Guo, Xiaobo Zhou, Jiayuan He, Ning Jiang

Faculty, Staff and Student Publications

The Optimal electrode configuration of Electroencephalograms (EEG) systems for mild cognitive impairment (MCI) detection and monitoring in non-clinical settings, i.e. number of electrodes and the positions of the electrodes, remains to be explored. In the current study, we explored the optimization of electrode configuration for MCI detection. We used a 32-channel EEG device to record the data of 21 MCI patients and 20 cognitively normal elderly (NC) undergoing working memory (WM) tasks. Based on the differential value (MCI group vs. NC group) from the Power Spectral Density (PSD) value of each electrode in θ and α frequency band during WM …

An Agent-Based Model Of Microglia And Neuron Interaction: Implications In Neurodegenerative Disease, Cheyenne Ty, Amanda Case, Emmanuel Mezzulo, Abigail Penland, Kamila Larripa

Spora: A Journal of Biomathematics

Whether immune cells protect or harm the brain is an open question depending on context, and their role is implicated in multiple diseases such as Alzheimer's disease, dementia, and other neurological disorders. Microglia, a specific type of immune cell in the central nervous system, play a key role in homeostasis, and genes associated with an elevated risk of Alzheimer's disease correspond with deficiencies in their behavior. We created an agent-based model that incorporates inflammatory signaling, chemotaxis, and phagocytosis of damaged neurons and allows the exploration of crucial pathways in the maintenance of brain health. We specifically investigated pathways related to …

On Solving Differential Equations Describing The Ecology Of Shallow Lakes: A Comparison Of Classical And Modern Computational Methods Through Python, Vruddhi Kapre, Jeffrey R. Anderson, Alessandro Maria Selvitella

Spora: A Journal of Biomathematics

In this exposition paper, we describe some computational methodologies to solve numerically differential equations modeling the shallow lake ecosystem, with particular focus on the dynamics of the phosphorus. We describe in detail Python implementations of classical algorithms, like Runge-Kutta, and more modern approaches, including physics-informed neural networks.

Another Milestone Achieved, Editorial Board

Spora: A Journal of Biomathematics

With due thanks to the Intercollegiate Biomathematics Alliance for their unending support, Spora is offering once again another highly respected platform for collaborative research in mathematics, biology, and related fields. Spora's role in disseminating work especially accessible to students makes it a unique platform to expand the body of knowledge in mathematical biology. Spora welcomes submissions related to Ph.D. dissertations, master's theses, and undergraduate research projects as well as original research.

Massera’S Theorem On Arbitrary Discrete Time Domains, Martin Bohner, Jaqueline G. Mesquita, Sabrina Streipert

Mathematics and Statistics Faculty Research & Creative Works

We present a general version of Massera's theorems for arbitrary discrete domains, based on a newly introduced definition for both linear and nonlinear equations. For scalar nonlinear equations, we identify sufficient conditions that ensure each µ-bounded solution approaches a periodic solution asymptotically. In the case of linear systems, we prove that the presence of a µ-bounded solution necessarily leads to a periodic solution. We also provide some examples to show the practical implications of our findings.

Reproductive Costs In Female, Island-Dwelling Eastern Diamondback Rattlesnakes (Crotalus Adamanteus), Emily R. Gray

Theses, Dissertations and Capstones

Eastern Diamondback Rattlesnakes (Crotalus adamanteus; EDBs) are a declining species endemic to the Southeastern Coastal Plain. Reproduction is costly for females, which are ovoviviparous, slow to mature, reproduce infrequently, and are often emaciated after parturition. Yet, we have a limited understanding of the trade-offs associated with their reproductive biology. Thus, I had three objectives: 1) assess reproduction-associated water stress and determine how female EDBs respond to altered water budgets in situ (Chapter 1), 2) evaluate the interactive effects of body condition and rainfall on female hydration, with a special focus on musculature as a condition index (Chapter 1), …

Analysis Of Phytochemicals In Watercress Leaves Using Chromatographic, Spectroscopic And In-Vitro Approaches, Bidisha Roy Sengupta

Faculty Publications

No abstract provided.

Biofilm-Based Biomonitoring Of Treated Wastewater Using Bacillus Thuringiensis: Toward Sustainable Water Reuse, Bidisha Roy Sengupta, Kefa K. Onchoke, Olabisi O. Ogunlewe, Robert Friedfeld

Faculty Publications

No abstract provided.

Collision Avoidance And Vegetation As Drivers Of Collective Motion In Australian Plague Locusts, Nathan S. Hasegawa

HMC Senior Theses

The Australian plague locust (Chortoicetes terminifera) is an agricultural and ecological pest that causes tens of millions of dollars in crop damage each year. In this thesis, we develop mathematical models of hopper bands, dense formations of juvenile locusts that move across a vegetated field and destroy plants in their path. We develop agent-based and PDE models of hopper bands moving through vegetation to examine how recently discovered behavior where locusts slow down to avoid collisions with other locusts may influence the shape, speed, and destructiveness of hopper bands. We find that collision avoidance may cause locusts to …

Investigating Drivers In Phytoplankton Between Lentic And Lotic Ecosystems Within Twelvepole Creek Watershed, Devin Lee Farmer

Theses, Dissertations and Capstones

Harmful Algal Blooms (HABs) threaten aquatic ecosystems, local economies, and water quality. While extensively studied in lakes (lentic systems), their impact on flowing waters (lotic systems) remains underexplored. This study examined algal drivers in both ecosystems within the same watershed, focusing on Beech Fork Lake (lentic) and Twelve Pole Creek (lotic). Key environmental factors, including pH, turbidity, dissolved oxygen, and nutrient levels, were measured using in situ sensors and laboratory analysis. Water samples were analyzed for nitrogen, phosphorus, and algal biomass for comparison to environmental conditions. Phytoplankton was preserved for identification in future research. By comparing these environments, this study …

Does Biofluorescence Enhance Visual Signals In Birds-Of-Paradise?, R. P. Martin, E. M. Carr, J. S. Sparks

School of Natural Resources: Faculty Publications

No abstract provided.

Mechanism Of Napthenic Acid Binding To Dissolved Organic Matter, Clarissa Jules

Theses and Dissertations

The oil sands in Alberta, Canada are being destroyed by oil extraction because remediation methods have proven largely ineffective. One toxic byproduct of oil extraction is a family of cyclical surfactant organic acids known as naphthenic acids (NAs). They are toxic to aquatic life, including fish, frogs, and aquatic birds. It is suspected that NAs bind to humic acid, a major organic component of soil, in dissolved organic matter in natural water, making them difficult to remove by conventional remediation methods. This problem prompts the following question: what is the binding mechanism between NAs and humic acid when dissolved in …

Protein-Metal Interactions Of A-Synuclein And Bioactive Transition Metals Via Molecular Dynamics, Gonzalo R. Vazquez

Theses and Dissertations

Parkinson’s Disease (PD) is a neurodegenerative movement disorder which has been found to target the dopaminergic neurons of the substantia nigra. It is characterized by the formation of masses known as Lewy Bodies, formed by aggregates of the intrinsically disordered protein (IDP) -synuclein (asyn). Research suggests that alpha synuclein can undergo aggregation in the presence of heavy metals, which may accumulate in the body through a variety of mechanisms. To study how metals may play a role in wildtype (WT) asyn aggregation, MD simulation of the protein was performed in the presence of bioactive transition metals including Fe2+, Fe3+, Cu+, …

Electrochemical And Conformational Patterns Of S-Glycosides And The Synthesis Of Schistosoma Mansoni Antigens, Bhavesh Rajendra Deore

Theses and Dissertations

This thesis dives into two relevant fields in carbohydrate science: reactivity and conformation. We centered our attention on S-glycosides, a common class of glycosyl donors and glycomimetics, to study the influence exerted by the structural architecture over the conformational properties about flexible bonds and the reactivity towards electrochemical activation. Studying the conformational properties of sugars is key to understanding the molecular recognition mechanisms underlying their biological functions. Moreover, a well understanding of how the molecular components affect free rotation about bonds can be valuable information to design improved glycomimetic drug candidates. On the other hand, electrosynthesis is a promising application …

Woody Plant Reinvasion Shortens The Lifespan Of Grassland Restoration Treatments, D. T. Fogarty, M. Beadle, C. R. Allen, C. Bielski, D. Twidwell

School of Natural Resources: Faculty Publications

No abstract provided.

Proximal Remote Sensing: An Essential Tool For Bridging The Gap Between High Resolution Ecosystem Monitoring And Global Ecology, Z. Pierrat, T. Magney, W. Richardson, B. Runkle, J. Diehl, X. Yang, J Gamon Et Al.

School of Natural Resources: Faculty Publications

No abstract provided.

Synthesis And Characterization Of Novel Coumarin Derivatives, Jeanmeil M. Nestor

Theses and Dissertations

An optimized approach toward the synthesis of representative coumarin derivatives is described. In addition to standard heat application methods, microwave-assisted coupling has proven beneficial in generating the targeted molecular hybrids which will serve as key templates in the development of new drugs to address resistance and specificity challenges. The coumarin moiety is a fantastic scaffold for molecular hybridization and has gained much warranted attention due to its efficacy in anticancer, antibacterial, and antitumor activity. In this research, novel molecular hybrids of umbelliferone were synthesized and fully characterized as new potential players in the anticancer, antitumor and antibiotic race, as well …

Adsorption And Recovery Studies Of Cadmium And Lead Ions Using Biowaste Adsorbents From Aqueous Solutions, Liang Feng

Theses and Dissertations

The use of low-cost biowaste adsorbents for the removal of toxic metal ions from aqueous solutions offers significant environmental benefits and demonstrates strong potential. This study evaluated luffa peels and chamomile flowers as low-cost biosorbents for the adsorption and recovery of Cd2+ and Pb2+ ions in both batch and column modes. To enhance adsorption capacity, the biosorbents were treated with 0.4 M HNO3 or 0.4 M NaOH. Fourier transform infrared spectroscopy (FTIR) characterization showed that surface OH, C=O, CO and COO groups played a role in the adsorption process. Batch adsorption studies indicated an order of adsorption capacity as follows: …

Analysis And Authentication Of An Optical Method For Early Detection Of Harmful Algal Blooms, Cody Schumacher

Theses, Dissertations and Capstones

The proliferation and frequency of harmful algal blooms (HABs) attributed to eutrophication, storm events and a changing climate have been an increasing concern in both lotic and lentic freshwater ecosystems. Methods of detecting HABs have been explored through fluorescent measurement and sample analysis, but are often expensive and time-consuming. A novel smart device application is in development to detect HABs based on images captured and analyzed by machine learning algorithms trained to distinguish potential cyanobacterial blooms. The HABs App model accurately detected cyanobacteria in strong relationship with biovolume concentrations (R² = 0.996) within the Greenup Pool of the Ohio …

The Effect Of Two Common Herbicides On The Growth And Development Of Two Anuran Species (Boreorana Sylvatica And Dryophytes Chrysoscelis), Jerica Eaton

Masters Theses & Specialist Projects

Amphibian populations have been declining globally since the 1950s. Many species that have experienced declines are viewed as 'environmental indicators' that reveal habitat degradation. Declines can be attributed to several factors, including chemicals used in agriculture, such as Roundup and Atrazine. Agrochemicals contaminate water bodies through runoff or leaching and cause alterations to aquatic ecosystems. This study evaluated the effects of herbicide usage on two wild anuran populations using wood frogs (Boreorana sylvatica) and Cope’s gray tree frogs (Dryophytes chrysoscelis) as a model. We determined the effect of the herbicides at two concentrations, a high concentration …

Developing Phenanthroimidazole-Based Fluorescent Sensors For Efficient Analyte Detection, Brian Kellogg

Masters Theses & Specialist Projects

The highly efficient design and synthesis of organic fluorophores with an excellent quantum yield have received extensive attention. Compared with instrumental techniques, fluorescent sensors derived from organic small molecules offer many impressive benefits, such as selective detection, lower cost, and higher efficiency. Various detection mechanisms such as colorimetric, ratiometric, and fluorescence turn on/off have been reported for single analyte detection. Developing molecular probes that are capable of detecting two (or more than two) different analytes (cations, anions, and/or biomolecules) had emerged as a new research area and attracted considerable attention in the field of chemo- and biosensors.

Phenanthroimidazole represents a …

Delineating Ecologically Distinct Groups For Annual Cycle Management Of A Declining Shorebird, E. C. Knight, J. Carlisle, A. J. Boyce, D. Bradley, P. Cimprich, S. Coates, L. A. Powell Et Al.

School of Natural Resources: Faculty Publications

No abstract provided.

“Science Belongs Everywhere”: Outlooks On Post-Secondary Stem Education For Correctional Centers In Virginia, Shelita R. Augustus

Division of Strategic Enrollment Management and Student Success Publications

Virginia has an incarceration rate of 679 per 100,000 residents, the highest among independent democratic nations. This scoping review examines perspectives on post-secondary STEM education to promote STEM education within Virginia's correctional facilities, assesses programs to improve rehabilitation, reduce recidivism, and address systemic inequalities by developing the scientific potential of incarcerated individuals. The review finds that while STEM education in correctional facilities faces limitations, its potential benefits are being realized nationwide. Virginia has made strides through initiatives like House Bill 2158, which aims to expand higher education access for incarcerated individuals. Examples such as the programs at J. Sargeant Reynolds …

Caves, Calculus, And Climate Change: Measuring And Modeling The Discharge Of Biz Falls In Mammoth Cave National Park, Ava Lich

Mahurin Honors College Capstone Experience/Thesis Projects

Climate change poses a significant global challenge, with increasing levels of atmospheric carbon dioxide as a primary driver of rising temperatures and environmental disruptions. Karst systems, such as those in South-Central Kentucky, play a role in sequestering atmospheric CO₂ through the dissolution of limestone, a process that forms unique landscapes while mitigating climate impacts. This study investigates the discharge dynamics of Cascade River in Great Onyx Cave to enhance understanding of the relationship between hydrology and carbon sequestration in karst environments. A barrel weir equipped with pressure transducers was employed to collect and measure water flow, and Torricelli’s law was …

Population Increases Of The Threatened American Burying Beetle (Nicrophorus Americanus) Linked To Large-Scale Collaborations In A Working Lands Ecoregion, C. P. Roberts, A. K. Ludwig, D. T. Fogarty, E. F. Stuber, Daniel R. Uden, T. L. Walker Jr., D. Twidwell

School of Natural Resources: Faculty Publications

No abstract provided.

Determining The Concentrations Of Trace Metals In Caffeinated Beverages By Icp-Aes, Lillian B. Gruss, James O'Donoghue, Maya Schram

Research and Creativity Symposium

A myriad of different caffeinated beverages are advertised and readily available to consumers. Previous research has identified the presence of elevated levels of metals unsafe for consumption in many of these beverages, energy drinks in particularly. We aim to analyze concentrations of chromium, aluminum, and lead, three such metals, in a variety of different caffeinated beverages. A calibration curve relating concentration of chromium, lead and aluminum to corrected peak height for five solutions of standardized concentration was created using a ThermoFisher iCAP 6000 Series. The same instrument was then used to analyze samples of eight different caffeinated beverages. The corrected …

Perspectivism And Wicked Problems: Patterns In The Discovery Process Of Leibniz, Bohr, And Turing, Ernesto Diaz

Natural Sciences and Mathematics | Faculty Authored Dissertations and Theses

This research investigates fundamental patterns in how transformative scientific knowledge emerges and becomes established, examining three pivotal cases: Leibniz's development of calculus, Bohr's formulation of complementarity, and Turing's conceptualisation of computation and artificial intelligence. The study introduces the o-é-c model (Ouverture Ontologique - Épistémè Socialisante - Connaissance Éclairante) to explain how individual insights become integrated into collective knowledge through structured phases of development. Drawing on Minsky's conception of knowledge as mental models for problem-solving and Longino's social epistemology, the research demonstrates how wicked problems—those that resist formulation within existing frameworks—catalyse the creation of new knowledge domains. The model reveals how …

Gompertz Distribution On Time Scales, Wasiu Sule

Theses, Dissertations and Capstones

We shall investigate Gompertz dynamic equations within the context of time scales calculus, by exploring the mathematical foundations and applications of the Gompertz model, which is commonly used to describe growth phenomena in various fields such as biology and economics. This research seeks to analyze the Gompertz cumulative distribution functions (CDF) and probability density functions (PDF) across different time scales, including the real numbers R and integer multiples hN. Probability techniques will be used to derive the CDF and PDF associated with the Gompertz dynamic equations, and we will examine how varying the time scale impacts the characteristics …

Discrete Fractional Gompertz Models, Rebecca Oduro

Theses, Dissertations and Capstones

This thesis explores the theory and application of discrete fractional Gompertz models—systems that integrate fractional difference operators into the classical Gompertz growth paradigm. By doing so, these models capture both discrete time steps and the long-range memory effects characteristic of fractional calculus. After outlining the fundamental notions of discrete calculus, discrete fractional sums and differences, and related special functions such as the discrete Mittag–Leffler function, we derive various fractional Gompertz-type equations. We prove the existence and uniqueness of solutions to these fractional difference equations, often employing discrete analogues of standard solution methods like variation of constants. We also investigate the …