Digital Commons Network^™

Joint Modelling Of Longitudinal Egfr Trajectory And Time To Acute Kidney Injury In Lung Transplant Patients, Samiha Zakir

Theses and Dissertations

Progressive declines in estimated glomerular filtration rate (eGFR) often precede acute kidney injury (AKI), yet the relationship between eGFR trends and AKI risk remains unclear. This study investigates longitudinal eGFR changes and their association with AKI in 459 lung transplant patients followed for up to 7 years (n = 6419). We applied a piecewise linear mixed-effects model to evaluate eGFR trajectories and a Cox proportional hazards model to assess time to AKI. A joint model was used to explore the interplay between longitudinal and survival processes. Key covariates included gender, age at transplantation, antibody-mediated rejection (AMR), and pre-transplant eGFR. Males …

Pastoral Land Condition: Kimberley Land Condition Standards, Robert Sudmeyer, Rick Fletcher, Kathryn Ryan, Matthew Fletcher, Charles Martin, Philip Thomas, Karen Holmes, Karyn Reeves, Wayne Fletcher

Natural resources published reports

This report outlines the conceptual basis and quantitative land condition standards that define acceptable pastoral land condition for the Kimberley, Western Australia (WA), to meet the regulatory requirements of the Land Administration Act 1997 and the Soil and Land Conservation Act 1945.

The Department of Primary Industries and Regional Development (DPIRD) develops regional-level pastoral land condition standards for WA to implement the Framework for sustainable pastoral management – Revised edition, which is designed to address the Office of the Auditor General’s recommendations to improve the management of pastoral lands in WA. The application of these standards is expected to …

Effects Of Environmentally Relevant Concentrations Of Roundup On Oxidative-Nitrative Stress, Cellular Apoptosis, Prooxidant-Antioxidant Homeostasis, Renin And Cyp1a Expressions In Goldfish: Molecular Mechanisms Underlying Kidney Damage During Roundup Exposure, Md Imran Noor, Md Saydur Rahman

School of Earth, Environmental, & Marine Sciences Faculty Publications

Roundup is one of the most widely used glyphosate-based harmful herbicides in the United States as well as globally, which poses a severe risk for terrestrial and aquatic organisms. In order to identify the detrimental effects of Roundup exposure in aquatic organisms, we investigated the environmentally relevant concentrations of Roundup exposure (low dose: 0.5 μg/L and high dose: 5.0 μg/L for 2 weeks) on renin expression, oxidative-nitrative stress biomarkers (e.g., 2,4-dinitrophenol, DNP; and 3-nitrotyrosine protein, NTP), prooxidant-antioxidant enzymes expressions (e.g., superoxide dismutase, SOD; and catalase, CAT), cellular apoptosis, and cytochrome P450 1A (CYP1A) mRNA levels in the kidneys of goldfish …

Microplastics In Coastal And Marine Environments: A Critical Issue Of Plastic Pollution On Marine Organisms, Seafood Contaminations, And Human Health Implications, Rebecca Muñiz, Md. Saydur Rahman

School of Earth, Environmental, & Marine Sciences Faculty Publications

Plastic has quickly become one of the world's most prevalent environmental pollutants. Population growth has only amplified the demand, resulting in 430 million tons of plastic produced annually, with 11 million tons ending up in our oceans. Without intentional intervention, plastic waste in the oceans is expected to triple, posing severe risks for the aquatic ecosystems, animals, and humans dependent on these waters. As plastic accumulates in oceans and other water environments, the non-biodegradable particles break down into micro- and nano-plastics, invading coastal and marine organisms and causing considerable physiological and morphological damage. This is especially concerning for the millions …

Evaluating Risk And Return Of Corn And Soybean Marketing Strategies Using Monte Carlo Simulation Methods, Johanna Ilves

Department of Agricultural Economics: Dissertations, Theses, and Student Research

This study evaluates the performance of pre-harvest marketing strategies for corn and soybeans, using Monte Carlo simulation techniques. Given the increasing volatility in commodity prices and the evolving landscape of agricultural markets, producers face growing challenges in developing effective marketing plans that manage risk and enhance profitability. This thesis examines thirteen marketing strategies from 2008 to 2024, including benchmark harvest-only sales and various pre-harvest futures contract approaches. Historical futures price data for December corn and November soybean contracts were used to simulate 1,000 marketing outcomes per strategy per year, capturing a broad range of market conditions. Key performance indicators such …

Walleye And Sauger Movement And Entrainment In Lewis And Clark Lake, William Joseph Radigan

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Walleye Sander vitreus and Sauger Sander canadensis are both socioeconomically important sportfish species in Lewis and Clark Lake, an interjurisdictionally managed mainstem Missouri River reservoir fishery. Since 2011, adult catch per unit effort (CPUE) of both Walleye and Sauger has remained at approximately 50% of pre-2011 levels. A presumed reason for the suppressed CPUE of adult Walleye and Sauger is substantial entrainment of larval and adult fish resulting from the reservoir’s high turnover rate (7.2 d). Acoustic telemetry was used to quantify adult movement and entrainment and ichthyoplankton trawls were used to assess larval entrainment. Relative importance of factors driving …

Landscape Effects On The Beneficial Arthropod Community In Agriculturally Dominated Environments, Hannah E. Stowe

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Ecosystem services in agriculturally dominated regions rely, at least in part, on arthropods. Environment and biodiversity influence beneficial arthropods in population size, community structure, diversity, and ecosystem service provisioning. Predation is among the most important services provided by arthropods in agroecosystems. Understanding what alters predation and predator activity can support the successful application of biological control and, more broadly, integrated pest management. Land use and edge adjacency, field characteristics, landscape, seasonality, and diel period all alter predatory behavior. Crop fields dominate Nebraska agroecosystems, although interspersed perennial grasslands persist through the Conservation Reserve Program (CRP). Such grasslands supply crucial resources and …

Optimizing Nitrogen Management: Assessing Nitrate Transport In The Deep Vadose Zone And Its Impact On Groundwater Quality In East-Central Nebraska, Muili O. Lawal

Department of Agricultural and Biological Systems Engineering: Dissertations, Theses, and Student Research

Groundwater contamination by nitrate (NO₃-N) is a growing environmental and public health concern driven largely by intensive agricultural fertilizer applications. The vadose zone plays an important role in NO₃-N transport, influencing groundwater quality and agricultural sustainability. This study investigated NO₃-N leaching dynamics in the deep vadose zone of Water Quality Sub-Area 30 (WQA30) within the Lower Loup Natural Resources District (LLNRD), northeast of Columbus, Nebraska (mean groundwater NO₃-N: 20.3 mg/L), using soil cores from 16 shallow (to 6.1 m) and four deep (down to 25.9 m) across four zones, two with inorganic fertilizer (Zones 1 and 4) and two with …

Constructing An Attractive Targeted Sugar Bait For Reducing Mosquito Populations, Xi Xian Ng

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Mosquito-borne pathogen transmission continues to pose a significant burden to global public health, well-being, and economic productivity. In the absence of universally available vaccines and amidst rising insecticide resistance that leads to product failures, there is an urgent need to develop new tools to mitigate mosquito-borne disease risk. Two general strategies exist to reduce transmission risk: personal protective measures and area-wide chemical interventions. Attractive Targeted Sugar Bait (ATSB) systems leverage the sugar-feeding behavior of mosquitoes—critical for sustaining their flight, metabolism, development, and fecundity—by delivering oral toxicants through attractively formulated sugar baits. This study aimed to develop an optimized ATSB formulation …

Synthesis And Characterization Of New Inorganic Materials In Different Length Scales; From Nanometer To Micrometer, Kirkland Sheriff

All Dissertations

In this dissertation there are a new series of Preyssler polyoxometalate (POM) crystalline solids created using electrochemical potential. It was found that using electrochemical potential, where nucleation and reduction occur simultaneously, was a convenient method for exploratory synthesis creating new crystalline solids in aqueous solution and at room temperature. The general structure feature reveals that Preyssler POM was covalently linked by various metals from the d and f block including Co²⁺, Ni²⁺, La³⁺, Nd³⁺, Gd³⁺ and Ho³⁺ where the POM was reduced by 2 to 4 electrons. The resulting solids …

Comparative Study Of Non-Iterative Seqential Method For Biot's Poroelasticity Model, Jeff Frimpong Amponsah

Open Access Theses & Dissertations

Linear poroelasticity theory describes the interaction between the motion of fluids and deformation of porous media. The theory serves various applications in a wide range of science and engineering fields, such as soil mechanics, oil reservoir modeling, and bio-medical applications. Partial differential equations are used to model the complex interaction between fluid flow and solid deformation in porous media. Since analytical solutions to these equations are rarely available for realistic problems, we resort to numerical solutions. One major advantage is their ability to provide accurate approximations of the solutions. Various numerical methods have been proposed to solve Biot's poroelasticity system. …

Alphamissense Predictions And Clinvar Annotations: A Deep Learning Approach To Uveal Melanoma, David J. Taylor Gonzalez, Mak B. Djulbegovic, Meghan Sharma, Michael Antonietti, Colin K. Kim, Vladimir N. Uversky, Carol L. Karp, Carol L. Shields, Matthew W. Wilson

Wills Eye Hospital Papers

OBJECTIVE: Uveal melanoma (UM) poses significant diagnostic and prognostic challenges due to its variable genetic landscape. We explore the use of a novel deep learning tool to assess the functional impact of genetic mutations in UM.

DESIGN: A cross-sectional bioinformatics exploratory data analysis of genetic mutations from UM cases.

SUBJECTS: Genetic data from patients diagnosed with UM were analyzed, explicitly focusing on missense mutations sourced from the Catalogue of Somatic Mutations in Cancer (COSMIC) database.

METHODS: We identified missense mutations frequently observed in UM using the COSMIC database, assessed their potential pathogenicity using AlphaMissense, and visualized mutations using AlphaFold. Clinical …

Ai Model For Predicting Asthma Prognosis In Children, Elham Sagheb, Chung-Il Wi, Katherine S King, Bhavani Singh Agnikula Kshatriya, Euijung Ryu, Hongfang Liu, Miguel A Park, Hee Yun Seol, Shauna M Overgaard, Deepak K Sharma, Young J Juhn, Sunghwan Sohn

Faculty, Staff and Student Publications

BACKGROUND: Childhood asthma often continues into adulthood, but some children experience remission. Utilizing electronic health records (EHRs) to predict asthma prognosis can aid health care providers and patients in developing effective prioritized care plans.

OBJECTIVE: We aimed to develop artificial intelligence (AI) models using various clinical variables extracted from EHRs to predict childhood asthma prognosis (remission vs no remission) in different age groups.

METHODS: We developed AI models utilizing patients' EHRs during the first 6, 9, or 12 years of their lives to predict their asthma prognosis status at ages 6 to 9, 9 to 12, or 12 to 15 …

Course Insight Portfolio: Math 1060 Calculus Of One Variable I, Julianne Barnhart, Rayna Elizabeth Maleki, Antsa Rakotondrafara

Publications

We presented this Course Insight Portfolio project as a final assignment for the class Teaching Undergraduate Math MATH 9700 in Summer 2025. It covers the Clemson class MATH 1060 Calculus of One Variable I and is a fruit of the collaborative work of Julianne Barnhart, Rayna Maleki, and Antsa Rakotondrafara.

Exploring The Biasing Effects Of Gender On Personality Disorder Diagnoses Formulated By Artificial Intelligence, Zoe Colclough

Student Theses

Gender bias is prevalent in personality disorder assessments, and while artificial intelligence has been posited as a solution to improve diagnostic objectivity and accuracy, the potential for such technologies to propagate human gender bias in mental health contexts remains underexplored. This study investigated the influences of gender bias on the diagnostic performance of ChatGPT-4o for personality disorders using three factorial research designs, which involved experimentally manipulating patient gender in a combined sample of 360 vignettes and case studies. Vignettes were synthesized through a novel artificial intelligence-assisted methodology established for this research, and case studies were identified from the literature. Significant …

Mechanistic Investigation Of Ring-Opening Polymerization Of Polycaprolactone Using Tin(Ii) Catalysts: Ligand Effects And Biomedical Applications, Eva-Larue M. Barber

Honors Scholar Theses

This research explores the mechanistic aspects of ring-opening polymerization (ROP) of ε-caprolactone (CL) to produce polycaprolactone (PCL), a biodegradable polymer widely used in biomedical applications. The study investigates how light exposure and catalyst concentration influence polymerization efficiency, using tin(II) 2-ethylhexanoate [Sn(Oct)₂] as the catalyst in a non-polar toluene solvent at 90 °C. Reactions were conducted under either ambient light or black light bulb (BLB) illumination, with monomer-to-catalyst ratios of 1:1 and 200:1.

Proton nuclear magnetic resonance (¹H NMR) spectroscopy was used to analyze conversion efficiency by tracking the disappearance of monomer signals and appearance of characteristic PCL peaks. Results revealed …

Latitudinal Gradients In Arctic Willows And Their Effects On Stream-Riparian Systems, Donal Heaney

Honors Scholar Theses

Extreme warming in the Arctic due to climate change presents the opportunity to study rapid changes to ecosystems and their potential resilience. Willow (Salix) shrubs form the base of many Arctic riparian ecosystems, and they have increased in height and range as temperatures have warmed. The effects of warming on willows could alter riparian ecosystems and neighboring streams, so understanding how climate change will affect willows is integral to understanding how the stream-riparian meta-ecosystem might change. I used data from the EvoME Institute to compare willow canopy cover above Arctic streams along a latitudinal transect and investigate how …

Cover Crop-Induced Improvements To Soil Hydraulic Properties And The Role Of Termination Time In Mitigating Negative Soil Moisture Impacts, Fabrizio Javier Pilco

Theses and Dissertations

In the Lower Rio Grande Valley of South Texas, water scarcity and drought pose ongoing challenges for farmers. Although cover crops are promoted for improving soil health and moisture, their effects on soil hydraulic properties in this region remain understudied. This thesis addresses both long-term (Chapter 2) and short-term (Chapter 3) impacts of cover crops on soil hydraulic properties and soil moisture. Long-term effects were evaluated through a three-year participatory field trial across four farms using a BACI design, while short terms were evaluated using a complete randomized block design. Soil hydraulic properties (residual water content θr, saturated water content …

The Effect Of Hiv-1 Infection Associated Bacterial Lipopolysaccharide (Lps) On Human Oral Keratinocytes: Implications For Promoting Chronic Inflammation, Md Shafayat Jamil

Theses and Dissertations

Human immunodeficiency virus type 1 (HIV-1) remains a major global health concern, affecting approximately 39 million people worldwide, with 500,000 new infections reported in 2022. While combined antiretroviral therapy (cART) has significantly reduced viral replication, HIV-1 infection is linked to various comorbidities, including oral dysbiosis and accelerated aging. Immune dysregulation in HIV-1–infected individuals promotes the proliferation of pathogenic gram-negative bacteria like Porphyromonas gingivalis, a key contributor to periodontal disease. P. gingivalis secretes lipopolysaccharide (LPS), which adversely affects human oral keratinocytes (HOK), the first line of defense against microbial threats in the oral cavity. HOK recognize LPS as a threat, …

Carbon Dioxide, Methane, And Nitrous Oxide Fluxes From Managed Aquatic Systems Of The Rio Grande Valley, Siena Rose Stassi

Theses and Dissertations

Greenhouse gas (GHG) dynamics from small-scale inland water remain relatively understudied, with knowledge gaps across ecosystem types and regions. In South Texas, there is a unique system of managed distributaries and their associated ox-bow lakes, commonly known as resacas. Most resacas are artificially managed and considered novel ecosystems, yet their GHG dynamics are unknown. Two resaca systems were monitored throughout one year to understand the magnitude, temporal variation, and environmental drivers of diffusive fluxes of carbon dioxide (CO2), methane (CH4), and nitrous oxide (N2O), along with ebullitive CH4 emissions. Emissions of both CO2 and CH4 peaked in hot summer months, …

Spatio-Temporal Pattern Of Nutrient Dynamics In The South Texas Coastal Watershed, Mohammad Sadman Alam

Theses and Dissertations

Eutrophication threatens aquatic ecosystems by altering productivity through excessive nutrient inputs. In some systems, primary productivity is limited by nitrogen (N), phosphorus (P), or both, based on the N:P ratio defined by the "Redfield" ratio. South Texas, facing rapid urban growth and industrialization, is at risk of higher nutrient loads, but research on nutrient dynamics in this region is limited. This study investigates nutrient variations in the freshwater (FW) abandoned distributaries of the Rio Grande and hypersaline saltwater (SW) systems. Results showed a significant decrease in dissolved inorganic nitrogen (DIN) and an increase in dissolved inorganic phosphorus (DIP), shifting the …

Inferring Feeding Biology In Extinct Shrews (Soricidae: Mammalia): Application Of A Linear Morphometric Approach, Derek J. Den Ouden

Electronic Theses and Dissertations

Linear morphometrics have been used extensively to infer the ecology of fossil organisms, but shrews have not yet been thoroughly explored using this technique. Often considered to have a homogenous insectivorous diet, direct dietary observation suggests shrew dietary diversity is substantial. Diversity of this nature is well established to have influenced skull morphology in other mammal clades, so similar patterns are hypothesized to be detectable in shrews. To test this, I examined the link between known diet and morphological disparity in extant shrews using linear morphometrics and then utilized that framework to infer the dietary ecology of several fossil taxa. …

Effects Of Ph On Product Yield Of One-Electron Oxidation To Guanine Derivatives, Abdul-Kadir Ibrahim

Electronic Theses and Dissertations

One-electron oxidation plays a major role in oxidative DNA damage in biological cells. Guanine, the most oxidizable DNA base, has been the major focus of studies on oxidative damage to DNA initiated by one-electron oxidation (OEO). The current study aims at understanding the mechanisms of photooxidation of guanine derivatives with OEO in acidic medium. D1A* and D1B*, which are the products of dGuo in acidic medium, were obtained from dGuo upon photolysis at 485 nm of the reaction mixture in the presence of S₂O₈^2- as the oxidant and Ru(II)(bpy)₃²⁺ as a photosensitizer. D1A* and …

Climate Prediction As An Adaptive Force-Multiplier: Reasons For Hope In A Rapidly Changing World, Matthew D. Laplante

All Graduate Theses and Dissertations, Fall 2023 to Present

It's not unreasonable to feel pessimistic about our future under climate change. But "believing the science" doesn't require you to accept that we are headed toward apocalypse. It is true that human-caused climate change is real, it is underway, and our societies face many increased risks because of it. But that's just part of what climate science tells us about our future world. This same field is responsible for the recent and rapid development of tools and techniques that permit the identification of patterns in our oceans and atmosphere that will aid us in making increasingly accurate predictions about climate—the …

Kinetic Analysis Of Hydrolysis And Hydrothermal Conversion Of Methyl Cellulose To Dodecane, Joseph Olembo Were

Electronic Theses and Dissertations

Environmental pollution due to emission of greenhouse gases and increasing global energy demand are some of the concerns associated Analysis with the use of fossil fuels. These concerns have triggered the exploration of sustainable and efficient methods for renewable energy production. One such method is the conversion of cellulosic biomass to hydrocarbon fuels using hydrogen bronze metals. Cellulose is the most abundant biomass globally, and thus its utilization can lead to more sustainable energy production. Previous studies have reported the conversion of cellulose to hydrocarbons at high temperatures and hydrogen pressure. This work focuses on the conversion of methyl cellulose …

A Kinetic Analysis On Hydrolysis And Hydrothermal Conversion Of Cellulose To Dodecane, Joel Nyangoka Onyancha

Electronic Theses and Dissertations

Cellulose, the most abundant biomass on Earth, offers a promising pathway for alternative energy through conversion into alkane hydrocarbons. Traditional methods rely on high temperatures and high-pressure hydrogen, often derived from petroleum. In this study, we investigated the conversion of Microcrystalline Cellulose using hydrogen metal oxides (bronzes) under milder conditions. Following ASTM E3417-24 hydrolysis protocols, we employed hydrogen bronzes with toluene for product extraction. This approach enabled conversion at lower temperatures without pressurized hydrogen. Products were analyzed using Gas Chromatography Mass Spectrometer for identification and Gas Chromatography Flame Ionization Detector for quantification. Our findings revealed the formation of a possible …

Impact Of Shear Flow On Marine Biofilms Using Hyperspectral Imaging, Shantanu Mahesh Kore

All Theses

Various microbial communities in marine biofilms cause biofouling on submerged surfaces, posing challenges to marine industries. Despite their ecological and economic importance, biofilms' biomechanical and biochemical responses to hydrodynamic shear stress are insufficiently understood, particularly in dynamic flow conditions. To fill this gap, our study uses an innovative fiber-optic hyperspectral imaging (HSI) system and a supercontinuum laser source to examine marine biofilms' structure, composition, and detachment behavior at different shear stress levels.

To detect spectral and spatial heterogeneity in live biofilms without labeling, we created a custom imaging pipeline that captures reflectance spectra in the 600-850 nm range, targeting microbial …

Algebraic Properties Of Boolean Models, Harrison Fisher

All Theses

Boolean models are n-tuples of polynomial functions in n variables over the finite field of order 2. These models define finite dynamical systems which are used for modeling many different biological systems such as gene regulatory networks. These systems can be defined by updating every function synchronously, or by updating one function at a time asynchronously. In this project, we discuss a method for reverse engineering the model space of all Boolean models which fit a set of partial asynchronous data. This method is a generalization of a known method for synchronous data. In addition, we show that given the …

Seaexam And Seabench: Benchmarking Llms With Local Multilingual Questions In Southeast Asia, Chaoqun Liu, Wenxuan Zhang, Jiahao Ying, Mahani Aljunied, Anh Tuan Luu, Lidong Bing

Research Collection School Of Computing and Information Systems

This study introduces two novel benchmarks, SeaExam and SeaBench, designed to evalu ate the capabilities of Large Language Models (LLMs) in Southeast Asian (SEA) application scenarios. Unlike existing multilingual datasets primarily derived from English translations, these benchmarks are constructed based on real world scenarios from SEA regions. SeaExam draws from regional educational exams to form a comprehensive dataset that encompasses sub jects such as local history and literature. In contrast, SeaBench is crafted around multi turn, open-ended tasks that reflect daily inter actions within SEA communities. Our evalua tions demonstrate that SeaExam and SeaBench more effectively discern LLM performance on …

A Herpetofaunal Inventory Study Of Two National Wildlife Refuges In The Mississippi Delta And Associated Evaluation Of Trapping Efficacy, Andrew Holzinger

Master's Theses

The objectives of this project were to record the diversity and distribution of amphibian and reptile species present at Panther Swamp and Hillside National Wildlife Refuges (NWR) and to quantify trapping efficacy as a result of various methodologies under different habitat variables. The primary methods employed were two varieties of drift fence trap arrays consisting of 100-foot sections of silt fencing with buried 2.5-gallon buckets as pitfall traps and box traps placed at the end of each fence to capture larger organisms. When conditions permitted, aquatic trapping was also employed across the Refuges. A total of 55 species were documented, …