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Optimizing Microscale Tesla Valve Design For Enhanced Efficiency For Filtering And Sorting Bacteria, Brian Ewalt Jan 2026

Optimizing Microscale Tesla Valve Design For Enhanced Efficiency For Filtering And Sorting Bacteria, Brian Ewalt

2026 Research Poster Competition

Invented by Nikola Tesla in 1920, a Tesla valve is a passive check valve with no moving parts but showing diodicity for fluids (i.e., allowing fluids to flow easily in one direction but not in the other). Tesla valves have demonstrated remarkable versatility across a range of scientific fields. Recently, a study conducted at the University of Arkansas showed that these conduits exhibited diodicity for bacteria in the absence of fluid flows (Rogers et al. 2023), serving as proof of concept for applying microscale Tesla valves for filtering and sorting bacteria and microorganisms in biomedical settings. However, the design of …


Chronostratigraphy Using Stable Carbon Isotopes Of The Elliot Formation, South Africa, Aidan Del Pino Jan 2026

Chronostratigraphy Using Stable Carbon Isotopes Of The Elliot Formation, South Africa, Aidan Del Pino

2026 Research Poster Competition

The Elliot Formation in South Africa preserves a fossil-bearing record spanning the Late Triassic–Early Jurassic, a time marked by significant environmental changes related to the Central Atlantic Magmatic Province (CAMP) and the end-Triassic extinction event. Despite its importance, the Elliot Formation remains poorly constrained due to limited chronostratigraphic markers. Chronostratigraphy is the branch of geology that correlates and dates rock units in time, allowing researchers to arrange these rock units into a chronological sequence. Globally, the Triassic–Jurassic boundary is characterized by a pronounced negative carbon isotope excursion linked to CAMP volcanism and the end Triassic extinction event. This C-isotope excursion …


Temporal Variational Graph Autoencoder For Influenza Evolution, Soumya Chauhan Jan 2026

Temporal Variational Graph Autoencoder For Influenza Evolution, Soumya Chauhan

2026 Research Poster Competition

Frequent mutations in influenza virus surface proteins can increase infectivity while evading human and vaccine immunity, causing seasonal epidemics. The CDC annually evaluates thousands of virus strains to predict mutated sequences likely to be dominant in the next season, which creates a need for methods that better capture how viral mutations evolve over time. In this study, we represent influenza protein sequences as a network-like graph, creating connections if sequences are collected a week apart and only differ by one mutation. This method explicitly considers time information as part of the evolution, while other existing methods analyze mutated sequences without …


Uav-Based Sensor Integration For In-Situ Lake Water Quality Monitoring, Alec Campbell Jan 2026

Uav-Based Sensor Integration For In-Situ Lake Water Quality Monitoring, Alec Campbell

2026 Research Poster Competition

Current water quality assessment methods rely heavily on manual sampling and laboratory analysis, which are time-consuming and difficult to perform in remote or hazardous environments. In surface water monitoring, spatial and temporal resolution is often constrained by labor, access, and logistical limitations of manual sampling programs. This research aims to develop a drone-based system for real-time, in situ lake water quality monitoring. To address these challenges, the project focuses on integrating multiple water quality sensors, including oxidation-reduction potential (ORP), pH, electrical conductivity (EC), turbidity, and a multispectral spectrometer, into a compact, UAV-compatible design capable of collecting spatially referenced data. Methods: …


Macroinvertebrate Taxonomic And Functional Diversity In The Spokane River Watershed, Kaitlin L. Abell Jan 2026

Macroinvertebrate Taxonomic And Functional Diversity In The Spokane River Watershed, Kaitlin L. Abell

EWU Masters Thesis Collection

Changes in land use, such as agricultural expansion, have impacted stream systems by modifying discharge, substrate diversity, channel morphology, and nutrient inputs. The Spokane River Watershed is heavily impacted by human activity, including urban and agricultural development. Rehabilitation efforts are being organized to reintroduce Salmonidae species in the Spokane River Watershed. The first step of this reintroduction is to perform habitat studies to inform allocation of restoration efforts. As part of this effort, I performed benthic macroinvertebrate surveys throughout the watershed.

The objective of my research was to use the macroinvertebrate community as a biological indicator to determine which habitat …


A Bayesian Late-Fusion Supportability Framework For Rare-Disease Severity Prediction In Glut1 Deficiency Syndrome, Jordan M. Rodriguez Jan 2026

A Bayesian Late-Fusion Supportability Framework For Rare-Disease Severity Prediction In Glut1 Deficiency Syndrome, Jordan M. Rodriguez

Mathematics Dissertations

Glucose transporter type 1 deficiency syndrome (GLUT1-DS) is a rare neurometabolic disorder with heterogeneous neurological and developmental severity. Because patient-level severity is not observed as a single validated outcome, this dissertation develops a Bayesian late-fusion supportability framework for constructing and predicting an ordered latent severity phenotype from clinical, genetic, and EEG-derived evidence. The primary target was constructed in a larger clinical cohort using age-5 symptom burden and learning cognition, then assigned to an aligned multimodal prediction cohort. Target-defining variables were excluded from supervised predictors, and models were evaluated using patient-exclusive cross-validation with training-fold preprocessing and fold-wise EEG PCA.

The primary …


Comparative Evaluation Of Hplc And Capillary Electrophoresis In Intestinal Permeability Of Oseltamivir Phosphate Via Single-Pass Intestinal Perfusion (Spip) Method, Senem Şanli, Gülpembe Halay, Mustafa Sinan Kaynak, Nurullah Şanlı Jan 2026

Comparative Evaluation Of Hplc And Capillary Electrophoresis In Intestinal Permeability Of Oseltamivir Phosphate Via Single-Pass Intestinal Perfusion (Spip) Method, Senem Şanli, Gülpembe Halay, Mustafa Sinan Kaynak, Nurullah Şanlı

Arts & Sciences Faculty Publications

Introduction: Oseltamivir phosphate (OP), a widely used antiviral prodrug for influenza, requires accurate Biopharmaceutics Classification System (BCS) classification to inform formulation and bioequivalence decisions. Despite its high solubility, the permeability characteristics of OP remain inadequately defined. Methods: This study evaluated the intestinal permeability of OP using the in situ Single-Pass Intestinal Perfusion (SPIP) model in male Sprague Dawley rats. Two validated analytical methods - High-Performance Liquid Chromatography (HPLC) and Capillary Zone Electrophoresis (CZE) were developed and compared. Metoprolol tartrate served as the high-permeability reference standard, and phenol red was used to monitor water flux. Permeability coefficients (Peff) were calculated after …


Environmental Monitoring In Shallow Lakes: Public Health Threats In Urban Waters, Kyleigh E. Johnson Jan 2026

Environmental Monitoring In Shallow Lakes: Public Health Threats In Urban Waters, Kyleigh E. Johnson

Theses and Dissertations

Lakes are an integral part of urban and suburban communities, providing ecological, recreational, and public health benefits. Many of these lakes are located in densely populated areas and are subject to urban influences on water quality. Algal toxins and Escherichia coli are two common recreational concerns. Algal toxins come from harmful algal blooms that are influenced by nutrient availability and temperature, while bacteria are often introduced through run-off and animal waste. Sampling every 3-4 weeks from May-October 2025 allowed for the assessment of seasonal patterns and site-specific differences across nine lakes in the Richmond area. The highest bacterial concentrations appeared …


Mathematical Models With Clinical Applications For Improving Health Outcomes, Helen Harris Jan 2026

Mathematical Models With Clinical Applications For Improving Health Outcomes, Helen Harris

Theses and Dissertations

In clinical settings, patients are exposed to many risks and stressors that could result in adverse health outcomes. Here we present mathematical models that seek to address these risks. First, we present a Markov Chain model to investigate the effect of medication reconciliation (MR) completion on patient health outcomes in the intensive care unit. Using this model, we simulate the annual incidence of adverse drug events (ADEs) for three different ADE rates. Based on the simulated results, we conduct a cost-benefit analysis for various levels of compliance to determine the financial implications of increasing MR completion depending on the baseline …


Absolute Quantification And Identification Of Rna From Rna-Lipid Nanoparticles Using High Resolution Mass Spectrometry, Jason C. Funderburk Jan 2026

Absolute Quantification And Identification Of Rna From Rna-Lipid Nanoparticles Using High Resolution Mass Spectrometry, Jason C. Funderburk

Theses and Dissertations

RNA therapeutics are a rising drug category with potential use for a range of conditions encompassing infectious diseases to therapies for cancer, diseases, and genetic disorders. RNA-lipid nanoparticles (RNA-LNPs) are the prominent delivery method for these therapeutics approved products include mRNA vaccines and polyneuropathy treatments. The emergency use authorizations and orphan drug status of current RNA-LNP drugs has allowed approval without finalization of the regulatory analytical procedures for quality monitoring. The objective of the study was to develop an LC-MS assay to simultaneously measure identity and concentration of two therapeutically relevant intact RNA constructs extracted from RNA-LNPs to enhance quality …


The Effects Of Overwash On Barrier Island Evolution And Building A Barrier Island Measure Of Resistance, Beth Thomas Jan 2026

The Effects Of Overwash On Barrier Island Evolution And Building A Barrier Island Measure Of Resistance, Beth Thomas

Theses and Dissertations

Barrier islands are critical for coastal communities, as they serve as a natural buffer against storm surge, waves, and the effects of rising sea levels, protecting life and property. These islands continuously evolve due to both normal and severe environmental conditions; global warming makes it increasingly difficult to predict the evolution of these islands due to increases in storm frequency and intensity. We present a cellular model of barrier island evolution consisting of biotic and abiotic processes including the effects of vegetation, wind, ocean currents, and gravity. The model is used to predict the future evolution of barrier islands off …


Machine Learning-Based Spatio-Temporal Modeling Of Climate Dynamics And Desertification In The Sahara–Sahel Region, Stephen M. Tivenan Jan 2026

Machine Learning-Based Spatio-Temporal Modeling Of Climate Dynamics And Desertification In The Sahara–Sahel Region, Stephen M. Tivenan

Theses and Dissertations

Arid climate classifications are threshold-dependent and easily interpretable mappings that are widely used in ecological, agricultural, and climate-related studies. These classifications inform scientific understanding, support policy and land management decisions, and provide an intuitive summary of environmental conditions. Despite their usefulness, traditional arid climate classifications often fail to quantify uncertainty, incorporate spatial context, or account for complex relationships among relevant environmental variables. Existing approaches to uncertainty assessment have largely relied on comparing classifications across multiple datasets or alternative formulas, but these methods generally overlook important spatial dependence and latent structure in the data.

This dissertation develops three machine learning-based statistical …


Evaluating Willow Establishment With Biochar For Remediation Of Mine Waste Soils: Amendment Ph Determines Plant Biomass And Metal Mobility, Madeline R. Webb Jan 2026

Evaluating Willow Establishment With Biochar For Remediation Of Mine Waste Soils: Amendment Ph Determines Plant Biomass And Metal Mobility, Madeline R. Webb

Dissertations, Master's Theses and Master's Reports

Heavy metal contaminated mine tailings (“stamp sands”) from historic copper mining inhibit plant establishment and contribute to ongoing metal contamination. Biochar amendments may enhance plant growth and reduce metal mobility in highly permeable mine waste soils, but the efficacies of different application methods or biochar sources and composition are uncertain. We evaluated different biochar sources (neutral or alkaline pH) and application methods (either mixed or layered) for planted willow growth, moisture retention, and metal mobility. A 10-week growth chamber experiment assessed plant performance, heavy metal content and heavy metal mobility in soil leachates and plant tissues. Biochar pH was the …


The Role Of Resistance Training In Managing Menopause-Related Changes, Alyson K. Strauss Jan 2026

The Role Of Resistance Training In Managing Menopause-Related Changes, Alyson K. Strauss

Honors Undergraduate Theses

Resistance training serves as a critical non-pharmacological strategy for mitigating the physiological and psychological declines associated with the menopausal transition. This natural biological phase, marked by declining estrogen levels, typically leads to accelerated bone mineral density loss, sarcopenia, metabolic regulation disturbance, and heightened mood disturbances. To evaluate the efficacy of targeted exercise interventions, a systematic review was conducted following PRISMA guidelines. From an initial pool of 60 relevant articles, 13 studies met the specific inclusion criteria, focusing on structured resistance training protocols for perimenopausal, menopausal, and postmenopausal cohorts.

The synthesis of these studies indicates that resistance training is a highly …


Lie-Galois Theory, Giovanni Reed Jan 2026

Lie-Galois Theory, Giovanni Reed

Honors Undergraduate Theses

Differential equations are a much-studied topic in the field of mathematics, as well as other sciences, such as engineering, economics, and biology. While much is known concerning these, there is still a large gap in our knowledge about such equations. It is important therefore, both to mathematics and other sciences, that we gain a more complete knowledge of differential equations, in particular the nature of their solutions. In this research, we investigate the solution space of linear ordinary differential equations (ODEs) from the standpoint of differential algebra. Differential algebra allows an ODE to be treated similarly to a polynomial, allowing …


Balancing Evidence Recovery: Hexane’S Effect On Biological And Non-Biological Traces In Sexual Assault Kits, Maya Richards Jan 2026

Balancing Evidence Recovery: Hexane’S Effect On Biological And Non-Biological Traces In Sexual Assault Kits, Maya Richards

Honors Undergraduate Theses

This study investigated the effectiveness of solvent – based extraction methods for the recovery of lubricant residues from simulated sexual assault swabs, with emphasis on balancing chemical evidence recovery. Sequential extraction using ultra – pure water followed by organic solvents, hexane, dichloromethane (DCM), and ethyl acetate (EA), was evaluated across water – based, silicone – based, oil – based, and hygiene product matrices. Analysis was performed using Direct Analysis in Real Time – High Resolution Mass Spectrometry (DART – HRMS), and extraction efficiency was assessed through spectral correlation with neat reference samples. Results demonstrated that solvent performance was highly dependent …


Evaluating The Comparison Of Different Body Locations For Data Collection Using Galvanic Skin Response Of Forensic Chemistry Students When In Lecture And Laboratory Environments, Elisa Guerrero Jan 2026

Evaluating The Comparison Of Different Body Locations For Data Collection Using Galvanic Skin Response Of Forensic Chemistry Students When In Lecture And Laboratory Environments, Elisa Guerrero

Honors Undergraduate Theses

Anxiety is the response that humans can have when exposed to a stimulus. It can be caused by a multitude of factors, such as psychological, biological, or physiological stimuli. Anxiety can be presented as a state or as a trait in a person. Trait anxiety is typically seen as a more stable personality trait, whereas state anxiety is a more intense temporary emotional state. In our study, anxiety was regarded as a more state-like characteristic. A galvanic skin response (GSR) Shimmer3+ device can measure skin electro-conductance changes following stimulation. In a situation where a participant is experiencing anxiety, levels of …


Techniques For Inclusive College Mathematics Classrooms, Christopher Anderson Davis, Josh Hiller, Anil Venkatesh Jan 2026

Techniques For Inclusive College Mathematics Classrooms, Christopher Anderson Davis, Josh Hiller, Anil Venkatesh

Journal of Mathematics and Science: Collaborative Explorations

Creating a welcoming and inclusive mathematics classroom is an important responsibility for all college mathematics faculty. But where do we begin? In this paper we present several techniques based on White’s (2024) building inclusive classrooms strategies framework, which the authors have found to be successful in making their own classrooms more inclusive. The techniques include the inclusion of contemporary diverse voices, exploring the history of applications of mathematical concepts, elevating the diverse intellectual history of mathematics, bringing diverse guest speakers into the classroom, and mentoring students as they engage in doing research. For each strategy we provide narrative comments based …


Connections Between Mathematics And Chemistry: An Interdisciplinary Undergraduate Curricular Initiative, George Ashline, Bret Findley Jan 2026

Connections Between Mathematics And Chemistry: An Interdisciplinary Undergraduate Curricular Initiative, George Ashline, Bret Findley

Journal of Mathematics and Science: Collaborative Explorations

In this article, we describe an undergraduate curricular initiative involving mathematics and chemistry faculty and students. Supported by a grant from the National Science Foundation Scholarships in Science, Technology, Engineering, and Mathematics Program, a program designed to encourage the study of and connections between quantitative fields and life sciences, this interdisciplinary collaboration features undergraduate student research and involves the development of curricular connections between mathematics and chemistry. Through this initiative, we have created activities for calculus courses featuring chemistry applications as well as activities for chemistry courses showcasing mathematical concepts. After the implementation of these curricular enhancements, we gathered student …


Full Issue Jan 2026

Full Issue

Journal of Mathematics and Science: Collaborative Explorations

No abstract provided.


A Major Update And Improved Validation Functionality In The Mwtab Python Library And The Metabolomics Workbench File Status Website, P. Travis Thompson, Hunter N. B. Moseley Jan 2026

A Major Update And Improved Validation Functionality In The Mwtab Python Library And The Metabolomics Workbench File Status Website, P. Travis Thompson, Hunter N. B. Moseley

Markey Cancer Center Faculty Publications

Background: The Metabolomics Workbench (MW) is a public scientific data repository consisting of experimental data and metadata from metabolomics studies collected with mass spectroscopy (MS) and nuclear magnetic resonance (NMR) analyses. Although not as rapidly as in the past, MW has steadily evolved, updating its mwTab and JSON deposition text file formats and its web-based infrastructure. However, the growth of MW has been exponential since its inception in 2013 and continues to be exponential, with the number of datasets hosted on the repository increasing by 50% since April 2024. As part of regular maintenance to keep up with changes to …


Assessment Of Soybean Response To Irrigation Variability In Eastern Nebraska Using The Aquacrop Model, Anmol Singh, Saleh Taghvaeian, Yufeng Ge, Derek M. Heeren, Frank Bai Jan 2026

Assessment Of Soybean Response To Irrigation Variability In Eastern Nebraska Using The Aquacrop Model, Anmol Singh, Saleh Taghvaeian, Yufeng Ge, Derek M. Heeren, Frank Bai

Department of Agricultural and Biological Systems Engineering: Faculty Publications

Soybean [Glycine max (L.) Merr.] is a major irrigated crop in eastern Nebraska, where recent expansions in irrigated agriculture and projected trends in irrigation demand necessitate thorough investigations of approaches that can optimize its irrigation management. In this study, the AquaCrop model was calibrated and validated using 19 variable irrigation treatments from a five-year field experiment. The model accurately simulated canopy cover, soil water content, and grain yield, with validation normalized root mean square error (nRMSE) of 12%, 7%, and 7%, respectively. The model was subsequently applied to estimate soybean yield and water requirement during a 15-year period (2010–2024) …


Impact Of Land Use On Soil Properties, Clay Mineralogy, And Behavior Of Ammonium Across A Precipitation Gradient, Isabel Delamater Jan 2026

Impact Of Land Use On Soil Properties, Clay Mineralogy, And Behavior Of Ammonium Across A Precipitation Gradient, Isabel Delamater

Theses and Dissertations--Plant and Soil Sciences

Like soil texture, clay mineralogy is considered a permanent or inherent characteristic of soils reflecting the influence of soil forming factors over long periods of time. Despite the importance of clay mineralogy in providing ecosystem services, much remains unknown about whether land use (native grassland sod versus no-tillage) can modify clay mineralogy under short periods of time. Furthermore, in no-tillage agroecosystems, lower crop yields are often ascribed to immobilization of added N fertilizer where inorganic nitrogen (such as ammonium) is converted to organic nitrogen. The possible role of clay mineralogy in retaining added ammonium has been overlooked in no-tillage systems. …


The Devil Is In The Det[Ai]Ls: Ai Agents, Ghost Students, And The Crisis Of Verified Presence In An Agentic Ai World, Aras Bozkurt, Helen Crompton, Caroline Fell Kurban Jan 2026

The Devil Is In The Det[Ai]Ls: Ai Agents, Ghost Students, And The Crisis Of Verified Presence In An Agentic Ai World, Aras Bozkurt, Helen Crompton, Caroline Fell Kurban

STEMPS Faculty Publications

The transition from reactive Generative Artificial Intelligence (GenAI) to agentic AI systems marks a categorical shift in digital education, moving beyond simple content generation to goal-oriented, autonomous execution. This paper explores the emergence of the “ghost student”: a digital surrogate created by the coupling of Large Language Models (the “mind”) and agentic AI browsers (the “body”). These entities are capable of navigating Learning Management Systems (LMS), engaging with content, and completing assessments with human-like mimicry, often rendering the actual learner’s presence optional. We argue that this phenomenon creates a verification gap that traditional proctoring and detection tools are structurally unable …


A Quantitative Analysis Of Burrowing And Subterranean Locomotion In The Sand Lance Using A Transparent Sediment, Issei Fujita, Makoto Tomiyasu, Jun Yamamoto, Yasuzumi Fujimori Jan 2026

A Quantitative Analysis Of Burrowing And Subterranean Locomotion In The Sand Lance Using A Transparent Sediment, Issei Fujita, Makoto Tomiyasu, Jun Yamamoto, Yasuzumi Fujimori

Journal of Marine Science and Technology–Taiwan

Sand lances (Ammodytes spp.) rely on rapid burrowing into sediment for predator avoidance. Although their sediment grain-size preferences are well documented, the biomechanics underlying burrowing success remain unclear because natural substrates are opaque. Using a transparent-sediment system, we directly visualized and quantified burrowing kinematics to: (1) test the effect of body size (total length, TL) on burrowing success; (2) examine entry mechanisms (e.g., swimming speed, entry angle); and (3) describe locomotion within sediment. Logistic regression on the full dataset (N = 28 fish) identified TL as the primary determinant of success, with larger individuals exhibiting significantly higher success …


Cruise Network Design Under Sequential Duopolistic Entry, Ta-Hui Yang, Ching-Hui Tang, Wan-Tien O Jan 2026

Cruise Network Design Under Sequential Duopolistic Entry, Ta-Hui Yang, Ching-Hui Tang, Wan-Tien O

Journal of Marine Science and Technology–Taiwan

This study addresses the network design for international cruise services in a duopolistic market, where carriers enter and make decisions sequentially. The leader, who makes the first move, makes decisions as there is no competitor in the market. The follower, who makes decisions later, has to design their network considering the existing leader’s network. The leader’s model is a mixed integer linear problem while the follower’s model is a mixed integer nonlinear problem. Therefore, a heuristic is proposed to solve the problem. The commercially available general algebraic modeling system is used in conjunction with its different solvers to solve the …


Effect Of Heat Treatment On The Corrosion And Wear Behavior Of 17-4 Ph Stainless Steel For Marine Applications, Syuan Tai, I-Kon Lee, Ming-Yuan Lin, Kang-Yu Liao, Chin-Chun Chang, Hung-Bin Lee Jan 2026

Effect Of Heat Treatment On The Corrosion And Wear Behavior Of 17-4 Ph Stainless Steel For Marine Applications, Syuan Tai, I-Kon Lee, Ming-Yuan Lin, Kang-Yu Liao, Chin-Chun Chang, Hung-Bin Lee

Journal of Marine Science and Technology–Taiwan

This study explores the tribocorrosion behavior of conventionally cast 17-4 PH stainless steel under real seawater conditions, focusing on the effects of three heat treatments (Solution, H900, H1100). Electrochemical tests, tribocorrosion experiments, SEM, XPS, and quantitative analysis were used to establish a three-stage tribocorrosion mechanism. Results show that H900 exhibits superior corrosion and wear resistance, while H1100 suffers increased material loss and surface cracking at high potentials. Elemental analysis revealed NbC migration forming third-body particles, which, although briefly reducing friction, induced local stress concentration and crack initiation. The findings highlight the critical influence of microstructure, passive film stability, and third-body …


Enhancing Underwater Imagery And Organism Detection Using Reinforcement Learning, K. Arul Deepa, P. Ramya, Karpaga Vinodha, Dharmaraja C Jan 2026

Enhancing Underwater Imagery And Organism Detection Using Reinforcement Learning, K. Arul Deepa, P. Ramya, Karpaga Vinodha, Dharmaraja C

Journal of Marine Science and Technology–Taiwan

Underwater environments pose significant challenges in assessing image quality and organism detection due to light scattering and absorption, which limits visibility and color fidelity. Existing solutions often fail to effectively address these challenges, resulting in suboptimal image quality and hindering organism identification. This paper examines the problem through a dual-focused approach: enhancing underwater images and detecting organisms using the Underwater Image Enhancement Benchmark (UIEB) dataset. The first step introduces a state-of-the-art method for image enhancement by applying reinforcement learning (RL) principles. By formulating the enhancement process as a Markov Decision Process (MDP)—where states are represented by image features and actions …


Crispr-Cas9 Unleashed: Gene-Slicing Adventures In The Cancer Battlefield, Shivakuma Sonnaila, Shilpi Agrawal Jan 2026

Crispr-Cas9 Unleashed: Gene-Slicing Adventures In The Cancer Battlefield, Shivakuma Sonnaila, Shilpi Agrawal

Chemistry & Biochemistry Faculty Publications and Presentations

Cancer, a global health menace, continues to pose significant challenges in terms of incidence and mortality, necessitating innovative therapeutic strategies. Despite existing treatments, the limitations persist, prompting a quest for novel approaches. The emergence of immunotherapy marked a transformative era in solid tumor treatments, yet its efficacy is constrained by adverse effects. Concurrently, the integration of advanced technologies into cancer treatment explores the vast potential residing at the molecular level through gene analysis and manipulation. This review articulates the role of state-of-the-art genome editing technology, notably clustered regularly interspaced short palindromic repeats (CRISPR-Cas9), in overcoming the constraints of immunotherapy for …


Nicotine, Bdnf, And Ꞵ-Adrenergic Ligand Receptors Regulate Soluble E-Cadherin Signaling In Non-Small Cell Long Cancer, Stuti Goel Jan 2026

Nicotine, Bdnf, And Ꞵ-Adrenergic Ligand Receptors Regulate Soluble E-Cadherin Signaling In Non-Small Cell Long Cancer, Stuti Goel

Senior Honors Theses and Projects

E-cadherin is a protein that normally helps cells adhere to each other. Sometimes, part of this protein is cleaved off and released outside the cell as soluble E-cadherin (sE-cad). When this happens, there is less E-cadherin left on the cell surface. Enzymes called matrix metalloproteases, especially MMP9, are responsible for this cleavage. In this study, we investigated E-cadherin in two non-small cell lung cancer cell lines, A549 and H1299. We found that treating these cells with brain-derived neurotrophic factor (BDNF), nicotine, or epinephrine increased the amount of MMP9 released into the surrounding media. When the cells were treated with propranolol, …